-- dump date 20120504_133621 -- class Genbank::misc_feature -- table misc_feature_note -- id note 862719000001 potential protein location (conserved protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 16S ribosomal RNA) 862719000002 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719000003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000004 DNA-binding site [nucleotide binding]; DNA binding site 862719000005 FCD domain; Region: FCD; cl11656 862719000006 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 862719000007 dimer interface [polypeptide binding]; other site 862719000008 TPP-binding site [chemical binding]; other site 862719000009 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 862719000010 PYR/PP interface [polypeptide binding]; other site 862719000011 dimer interface [polypeptide binding]; other site 862719000012 TPP binding site [chemical binding]; other site 862719000013 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 862719000014 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719000015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000016 putative DNA binding site [nucleotide binding]; other site 862719000017 putative Zn2+ binding site [ion binding]; other site 862719000018 Helix-turn-helix domains; Region: HTH; cl00088 862719000019 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719000020 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000021 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000022 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719000023 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 862719000024 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 862719000025 putative trimer interface [polypeptide binding]; other site 862719000026 putative CoA binding site [chemical binding]; other site 862719000027 fumarate hydratase; Provisional; Region: PRK15389 862719000028 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 862719000029 Fumarase C-terminus; Region: Fumerase_C; cl00795 862719000030 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 862719000031 CcdB protein; Region: CcdB; cl03380 862719000032 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 862719000033 active site 862719000034 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 862719000035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000036 dimer interface [polypeptide binding]; other site 862719000037 phosphorylation site [posttranslational modification] 862719000038 oxaloacetate decarboxylase; Provisional; Region: PRK14040 862719000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000040 ATP binding site [chemical binding]; other site 862719000041 Mg2+ binding site [ion binding]; other site 862719000042 G-X-G motif; other site 862719000043 Cupin domain; Region: Cupin_2; cl09118 862719000044 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862719000045 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 862719000046 active site 862719000047 Domain of unknown function (DUF697); Region: DUF697; cl12064 862719000048 YcjX-like family, DUF463; Region: DUF463; cl01193 862719000049 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 862719000050 active site 862719000051 catalytic residues [active] 862719000052 metal binding site [ion binding]; metal-binding site 862719000053 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 862719000054 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719000055 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719000056 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 862719000057 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719000058 carboxyltransferase (CT) interaction site; other site 862719000059 biotinylation site [posttranslational modification]; other site 862719000060 enoyl-CoA hydratase; Provisional; Region: PRK05995 862719000061 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719000062 substrate binding site [chemical binding]; other site 862719000063 oxyanion hole (OAH) forming residues; other site 862719000064 trimer interface [polypeptide binding]; other site 862719000065 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 862719000066 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719000067 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719000068 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719000069 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 862719000070 FAD binding site [chemical binding]; other site 862719000071 homotetramer interface [polypeptide binding]; other site 862719000072 substrate binding pocket [chemical binding]; other site 862719000073 catalytic base [active] 862719000074 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 862719000075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719000076 dimer interface [polypeptide binding]; other site 862719000077 active site 862719000078 isovaleryl-CoA dehydrogenase; Region: PLN02519 862719000079 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 862719000080 substrate binding site [chemical binding]; other site 862719000081 FAD binding site [chemical binding]; other site 862719000082 catalytic base [active] 862719000083 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 862719000084 Membrane transport protein; Region: Mem_trans; cl09117 862719000085 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 862719000086 active site 862719000087 homopentamer interface [polypeptide binding]; other site 862719000088 PAS domain S-box; Region: sensory_box; TIGR00229 862719000089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000090 putative active site [active] 862719000091 heme pocket [chemical binding]; other site 862719000092 PAS fold; Region: PAS_4; pfam08448 862719000093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000094 putative active site [active] 862719000095 heme pocket [chemical binding]; other site 862719000096 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719000097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000098 putative active site [active] 862719000099 heme pocket [chemical binding]; other site 862719000100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000101 dimer interface [polypeptide binding]; other site 862719000102 phosphorylation site [posttranslational modification] 862719000103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000104 ATP binding site [chemical binding]; other site 862719000105 Mg2+ binding site [ion binding]; other site 862719000106 G-X-G motif; other site 862719000107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719000108 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719000110 Helix-turn-helix domains; Region: HTH; cl00088 862719000111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719000112 dimerization interface [polypeptide binding]; other site 862719000113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000114 putative substrate translocation pore; other site 862719000115 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719000116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719000117 Coenzyme A binding pocket [chemical binding]; other site 862719000118 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 862719000119 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719000120 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719000121 Walker A/P-loop; other site 862719000122 ATP binding site [chemical binding]; other site 862719000123 Q-loop/lid; other site 862719000124 ABC transporter signature motif; other site 862719000125 Walker B; other site 862719000126 D-loop; other site 862719000127 H-loop/switch region; other site 862719000128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719000129 ABC-ATPase subunit interface; other site 862719000130 dimer interface [polypeptide binding]; other site 862719000131 putative PBP binding regions; other site 862719000132 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 862719000133 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 862719000134 putative ligand binding residues [chemical binding]; other site 862719000135 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 862719000136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719000137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719000138 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 862719000139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719000140 N-terminal plug; other site 862719000141 ligand-binding site [chemical binding]; other site 862719000142 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 862719000143 Helix-turn-helix domains; Region: HTH; cl00088 862719000144 Replication initiator protein A; Region: RPA; cl02339 862719000145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719000146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719000147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719000148 P-loop; other site 862719000149 Magnesium ion binding site [ion binding]; other site 862719000150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719000151 Magnesium ion binding site [ion binding]; other site 862719000152 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 862719000153 ParB-like nuclease domain; Region: ParBc; cl02129 862719000154 KorB domain; Region: KorB; pfam08535 862719000155 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 862719000156 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719000157 Uncharacterized conserved protein [Function unknown]; Region: COG4278 862719000158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719000159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000161 ATP binding site [chemical binding]; other site 862719000162 Mg2+ binding site [ion binding]; other site 862719000163 G-X-G motif; other site 862719000164 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000166 active site 862719000167 phosphorylation site [posttranslational modification] 862719000168 intermolecular recognition site; other site 862719000169 dimerization interface [polypeptide binding]; other site 862719000170 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719000171 PAS fold; Region: PAS_4; pfam08448 862719000172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000173 PAS fold; Region: PAS_3; pfam08447 862719000174 putative active site [active] 862719000175 heme pocket [chemical binding]; other site 862719000176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719000177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000178 dimer interface [polypeptide binding]; other site 862719000179 phosphorylation site [posttranslational modification] 862719000180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000181 ATP binding site [chemical binding]; other site 862719000182 Mg2+ binding site [ion binding]; other site 862719000183 G-X-G motif; other site 862719000184 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000186 active site 862719000187 phosphorylation site [posttranslational modification] 862719000188 intermolecular recognition site; other site 862719000189 dimerization interface [polypeptide binding]; other site 862719000190 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000192 active site 862719000193 phosphorylation site [posttranslational modification] 862719000194 intermolecular recognition site; other site 862719000195 dimerization interface [polypeptide binding]; other site 862719000196 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 862719000197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719000198 Helix-turn-helix domains; Region: HTH; cl00088 862719000199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719000200 dimerization interface [polypeptide binding]; other site 862719000201 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 862719000202 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 862719000203 putative dimer interface [polypeptide binding]; other site 862719000204 [2Fe-2S] cluster binding site [ion binding]; other site 862719000205 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 862719000206 putative dimer interface [polypeptide binding]; other site 862719000207 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 862719000208 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 862719000209 SLBB domain; Region: SLBB; pfam10531 862719000210 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 862719000211 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 862719000212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719000213 catalytic loop [active] 862719000214 iron binding site [ion binding]; other site 862719000215 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 862719000216 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719000217 [4Fe-4S] binding site [ion binding]; other site 862719000218 molybdopterin cofactor binding site; other site 862719000219 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 862719000220 molybdopterin cofactor binding site; other site 862719000221 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 862719000222 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 862719000223 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 862719000224 dimer interface [polypeptide binding]; other site 862719000225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719000226 metal binding site [ion binding]; metal-binding site 862719000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 862719000228 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719000229 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719000230 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719000231 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000232 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 862719000233 putative ligand binding site [chemical binding]; other site 862719000234 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 862719000235 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000236 TM-ABC transporter signature motif; other site 862719000237 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719000238 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000239 TM-ABC transporter signature motif; other site 862719000240 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 862719000241 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719000242 Walker A/P-loop; other site 862719000243 ATP binding site [chemical binding]; other site 862719000244 Q-loop/lid; other site 862719000245 ABC transporter signature motif; other site 862719000246 Walker B; other site 862719000247 D-loop; other site 862719000248 H-loop/switch region; other site 862719000249 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 862719000250 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719000251 Walker A/P-loop; other site 862719000252 ATP binding site [chemical binding]; other site 862719000253 Q-loop/lid; other site 862719000254 ABC transporter signature motif; other site 862719000255 Walker B; other site 862719000256 D-loop; other site 862719000257 H-loop/switch region; other site 862719000258 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 862719000259 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 862719000260 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719000261 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719000262 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719000263 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719000264 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000265 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 862719000266 putative N-terminal domain interface [polypeptide binding]; other site 862719000267 putative dimer interface [polypeptide binding]; other site 862719000268 putative substrate binding pocket (H-site) [chemical binding]; other site 862719000269 transcriptional regulator; Provisional; Region: PRK10632 862719000270 Helix-turn-helix domains; Region: HTH; cl00088 862719000271 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 862719000272 putative effector binding pocket; other site 862719000273 putative dimerization interface [polypeptide binding]; other site 862719000274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719000275 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719000276 substrate binding pocket [chemical binding]; other site 862719000277 membrane-bound complex binding site; other site 862719000278 hinge residues; other site 862719000279 Uncharacterized conserved protein [Function unknown]; Region: COG1262 862719000280 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 862719000281 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719000282 dinuclear metal binding motif [ion binding]; other site 862719000283 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719000284 CoenzymeA binding site [chemical binding]; other site 862719000285 subunit interaction site [polypeptide binding]; other site 862719000286 PHB binding site; other site 862719000287 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 862719000288 23S rRNA interface [nucleotide binding]; other site 862719000289 L3 interface [polypeptide binding]; other site 862719000290 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 862719000291 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 862719000292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000293 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862719000294 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 862719000295 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 862719000296 trimer interface [polypeptide binding]; other site 862719000297 putative metal binding site [ion binding]; other site 862719000298 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719000299 ligand binding site [chemical binding]; other site 862719000300 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719000301 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719000302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000303 DNA-binding site [nucleotide binding]; DNA binding site 862719000304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719000305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719000306 homodimer interface [polypeptide binding]; other site 862719000307 catalytic residue [active] 862719000308 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 862719000309 trehalose synthase; Region: treS_nterm; TIGR02456 862719000310 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 862719000311 active site 862719000312 catalytic site [active] 862719000313 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 862719000314 glycogen branching enzyme; Provisional; Region: PRK05402 862719000315 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 862719000316 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 862719000317 active site 862719000318 catalytic site [active] 862719000319 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 862719000320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000321 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 862719000322 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 862719000323 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 862719000324 active site 862719000325 catalytic site [active] 862719000326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000327 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000328 active site 862719000329 phosphorylation site [posttranslational modification] 862719000330 intermolecular recognition site; other site 862719000331 dimerization interface [polypeptide binding]; other site 862719000332 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 862719000333 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 862719000334 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000335 Transposase domain (DUF772); Region: DUF772; cl15789 862719000336 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 862719000337 Int/Topo IB signature motif; other site 862719000338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719000339 DNA binding residues [nucleotide binding] 862719000340 dimerization interface [polypeptide binding]; other site 862719000341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719000342 non-specific DNA binding site [nucleotide binding]; other site 862719000343 salt bridge; other site 862719000344 sequence-specific DNA binding site [nucleotide binding]; other site 862719000345 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000346 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 862719000347 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719000348 active site residue [active] 862719000349 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 862719000350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000351 Family description; Region: UvrD_C_2; cl15862 862719000352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000353 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 862719000354 Restriction endonuclease; Region: Mrr_cat; cl00516 862719000355 Protein kinase domain; Region: Pkinase; pfam00069 862719000356 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719000357 active site 862719000358 ATP binding site [chemical binding]; other site 862719000359 substrate binding site [chemical binding]; other site 862719000360 activation loop (A-loop); other site 862719000361 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719000362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000364 Family description; Region: UvrD_C_2; cl15862 862719000365 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 862719000366 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 862719000367 AIPR protein; Region: AIPR; pfam10592 862719000368 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 862719000369 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 862719000370 Int/Topo IB signature motif; other site 862719000371 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 862719000372 NMDA receptor-regulated protein 1; Region: NARP1; pfam12569 862719000373 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000374 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000375 Evidence 7 : Gene remnant 862719000376 Evidence 7 : Gene remnant; Product type pm : putative membrane component 862719000377 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 862719000378 Bacterial Ig-like domain; Region: Big_5; cl01012 862719000379 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 862719000380 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 862719000381 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000382 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000383 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000384 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000385 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000386 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719000388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000389 active site 862719000390 phosphorylation site [posttranslational modification] 862719000391 intermolecular recognition site; other site 862719000392 dimerization interface [polypeptide binding]; other site 862719000393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719000394 DNA binding site [nucleotide binding] 862719000395 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719000396 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719000397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000398 dimer interface [polypeptide binding]; other site 862719000399 phosphorylation site [posttranslational modification] 862719000400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000401 ATP binding site [chemical binding]; other site 862719000402 Mg2+ binding site [ion binding]; other site 862719000403 G-X-G motif; other site 862719000404 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719000405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 862719000406 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719000407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719000408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000409 active site 862719000410 phosphorylation site [posttranslational modification] 862719000411 intermolecular recognition site; other site 862719000412 dimerization interface [polypeptide binding]; other site 862719000413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719000414 DNA binding site [nucleotide binding] 862719000415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719000416 phosphorylation site [posttranslational modification] 862719000417 dimer interface [polypeptide binding]; other site 862719000418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000419 ATP binding site [chemical binding]; other site 862719000420 Mg2+ binding site [ion binding]; other site 862719000421 G-X-G motif; other site 862719000422 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 862719000423 Helix-turn-helix domains; Region: HTH; cl00088 862719000424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000425 PAS domain; Region: PAS_9; pfam13426 862719000426 putative active site [active] 862719000427 heme pocket [chemical binding]; other site 862719000428 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 862719000429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719000430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000431 putative CheW interface [polypeptide binding]; other site 862719000432 PilZ domain; Region: PilZ; cl01260 862719000433 Helix-turn-helix domains; Region: HTH; cl00088 862719000434 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 862719000435 Helix-turn-helix domains; Region: HTH; cl00088 862719000436 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000437 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719000438 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719000439 Walker A/P-loop; other site 862719000440 ATP binding site [chemical binding]; other site 862719000441 Q-loop/lid; other site 862719000442 ABC transporter signature motif; other site 862719000443 Walker B; other site 862719000444 D-loop; other site 862719000445 H-loop/switch region; other site 862719000446 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 862719000447 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000448 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000449 TM-ABC transporter signature motif; other site 862719000450 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000451 TM-ABC transporter signature motif; other site 862719000452 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000453 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 862719000454 putative ligand binding site [chemical binding]; other site 862719000455 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719000456 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719000457 Walker A/P-loop; other site 862719000458 ATP binding site [chemical binding]; other site 862719000459 Q-loop/lid; other site 862719000460 ABC transporter signature motif; other site 862719000461 Walker B; other site 862719000462 D-loop; other site 862719000463 H-loop/switch region; other site 862719000464 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 862719000465 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000466 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719000467 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000468 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862719000469 N-terminal domain interface [polypeptide binding]; other site 862719000470 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000472 active site 862719000473 phosphorylation site [posttranslational modification] 862719000474 intermolecular recognition site; other site 862719000475 dimerization interface [polypeptide binding]; other site 862719000476 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719000477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000478 NAD(P) binding site [chemical binding]; other site 862719000479 active site 862719000480 TM1410 hypothetical-related protein; Region: DUF297; cl00997 862719000481 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 862719000482 putative active site [active] 862719000483 TPR repeat; Region: TPR_11; pfam13414 862719000484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719000485 binding surface 862719000486 TPR motif; other site 862719000487 GAF domain; Region: GAF; cl15785 862719000488 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 862719000489 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 862719000490 Predicted membrane protein [Function unknown]; Region: COG4267 862719000491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000492 S-adenosylmethionine binding site [chemical binding]; other site 862719000493 Transposase domain (DUF772); Region: DUF772; cl15789 862719000494 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000496 dimerization interface [polypeptide binding]; other site 862719000497 putative DNA binding site [nucleotide binding]; other site 862719000498 putative Zn2+ binding site [ion binding]; other site 862719000499 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 862719000500 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719000501 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719000502 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 862719000503 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719000504 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 862719000505 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719000506 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719000507 Protein export membrane protein; Region: SecD_SecF; cl14618 862719000508 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719000509 active site residue [active] 862719000510 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719000511 Helix-turn-helix domains; Region: HTH; cl00088 862719000512 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719000513 dimerization interface [polypeptide binding]; other site 862719000514 substrate binding pocket [chemical binding]; other site 862719000515 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719000516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000517 NAD(P) binding site [chemical binding]; other site 862719000518 active site 862719000519 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719000520 TPP-binding site [chemical binding]; other site 862719000521 dimer interface [polypeptide binding]; other site 862719000522 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 862719000523 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719000524 PYR/PP interface [polypeptide binding]; other site 862719000525 dimer interface [polypeptide binding]; other site 862719000526 TPP binding site [chemical binding]; other site 862719000527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719000528 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719000529 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719000530 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719000531 DctM-like transporters; Region: DctM; pfam06808 862719000532 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719000533 fructose-bisphosphate aldolase; Region: PLN02858 862719000534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000535 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 862719000536 substrate binding site [chemical binding]; other site 862719000537 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719000538 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 862719000539 substrate binding site [chemical binding]; other site 862719000540 ligand binding site [chemical binding]; other site 862719000541 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 862719000542 Isochorismatase family; Region: Isochorismatase; pfam00857 862719000543 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 862719000544 catalytic triad [active] 862719000545 conserved cis-peptide bond; other site 862719000546 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 862719000547 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719000548 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 862719000549 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 862719000550 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 862719000551 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 862719000552 tetramer interface [polypeptide binding]; other site 862719000553 active site 862719000554 Mg2+/Mn2+ binding site [ion binding]; other site 862719000555 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719000556 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719000557 Walker A/P-loop; other site 862719000558 ATP binding site [chemical binding]; other site 862719000559 Q-loop/lid; other site 862719000560 ABC transporter signature motif; other site 862719000561 Walker B; other site 862719000562 D-loop; other site 862719000563 H-loop/switch region; other site 862719000564 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719000565 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719000566 Walker A/P-loop; other site 862719000567 ATP binding site [chemical binding]; other site 862719000568 Q-loop/lid; other site 862719000569 ABC transporter signature motif; other site 862719000570 Walker B; other site 862719000571 D-loop; other site 862719000572 H-loop/switch region; other site 862719000573 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000574 TM-ABC transporter signature motif; other site 862719000575 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000576 TM-ABC transporter signature motif; other site 862719000577 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000578 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 862719000579 putative ligand binding site [chemical binding]; other site 862719000580 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719000581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000582 DNA-binding site [nucleotide binding]; DNA binding site 862719000583 UTRA domain; Region: UTRA; cl01230 862719000584 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719000585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719000586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719000587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000588 dimer interface [polypeptide binding]; other site 862719000589 putative CheW interface [polypeptide binding]; other site 862719000590 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862719000591 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719000592 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719000593 ABC transporter; Region: ABC_tran_2; pfam12848 862719000594 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719000595 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 862719000596 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 862719000597 putative catalytic cysteine [active] 862719000598 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 862719000599 putative active site [active] 862719000600 metal binding site [ion binding]; metal-binding site 862719000601 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719000602 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719000603 active site 862719000604 substrate binding site [chemical binding]; other site 862719000605 activation loop (A-loop); other site 862719000606 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 862719000607 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 862719000608 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719000609 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719000610 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719000611 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719000612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000613 Walker A/P-loop; other site 862719000614 ATP binding site [chemical binding]; other site 862719000615 Q-loop/lid; other site 862719000616 ABC transporter signature motif; other site 862719000617 Walker B; other site 862719000618 D-loop; other site 862719000619 H-loop/switch region; other site 862719000620 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 862719000621 catalytic triad [active] 862719000622 dimer interface [polypeptide binding]; other site 862719000623 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 862719000624 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 862719000625 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 862719000626 enolase; Provisional; Region: eno; PRK00077 862719000627 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862719000628 dimer interface [polypeptide binding]; other site 862719000629 metal binding site [ion binding]; metal-binding site 862719000630 substrate binding pocket [chemical binding]; other site 862719000631 acyl-CoA esterase; Provisional; Region: PRK10673 862719000632 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 862719000633 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 862719000634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719000635 active site residue [active] 862719000636 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 862719000637 active site residue [active] 862719000638 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719000639 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 862719000640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719000641 catalytic residue [active] 862719000642 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 862719000643 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 862719000644 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 862719000645 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 862719000646 GatB domain; Region: GatB_Yqey; cl11497 862719000647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000648 PAS fold; Region: PAS_3; pfam08447 862719000649 putative active site [active] 862719000650 heme pocket [chemical binding]; other site 862719000651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000652 putative active site [active] 862719000653 heme pocket [chemical binding]; other site 862719000654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000656 dimer interface [polypeptide binding]; other site 862719000657 phosphorylation site [posttranslational modification] 862719000658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000659 ATP binding site [chemical binding]; other site 862719000660 Mg2+ binding site [ion binding]; other site 862719000661 G-X-G motif; other site 862719000662 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 862719000663 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862719000664 metal binding site [ion binding]; metal-binding site 862719000665 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719000666 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 862719000667 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 862719000668 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 862719000669 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000670 Cupin domain; Region: Cupin_2; cl09118 862719000671 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 862719000672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000673 putative substrate translocation pore; other site 862719000674 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 862719000675 thiamine phosphate binding site [chemical binding]; other site 862719000676 active site 862719000677 pyrophosphate binding site [ion binding]; other site 862719000678 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719000679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000680 DNA-binding site [nucleotide binding]; DNA binding site 862719000681 FCD domain; Region: FCD; cl11656 862719000682 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719000683 pyruvate kinase; Provisional; Region: PRK06247 862719000684 domain interfaces; other site 862719000685 active site 862719000686 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 862719000687 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000688 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719000689 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 862719000690 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719000691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719000692 Coenzyme A binding pocket [chemical binding]; other site 862719000693 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 862719000694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000695 putative substrate translocation pore; other site 862719000696 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 862719000697 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719000698 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 862719000699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000700 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 862719000701 FOG: CBS domain [General function prediction only]; Region: COG0517 862719000702 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719000703 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 862719000704 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 862719000705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000706 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 862719000707 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 862719000708 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 862719000709 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 862719000710 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 862719000711 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 862719000712 active site 862719000713 catalytic site [active] 862719000714 tetramer interface [polypeptide binding]; other site 862719000715 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 862719000716 active site 862719000717 homotetramer interface [polypeptide binding]; other site 862719000718 glyoxylate carboligase; Provisional; Region: PRK11269 862719000719 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719000720 PYR/PP interface [polypeptide binding]; other site 862719000721 dimer interface [polypeptide binding]; other site 862719000722 TPP binding site [chemical binding]; other site 862719000723 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 862719000724 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862719000725 TPP-binding site [chemical binding]; other site 862719000726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719000727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000728 dimer interface [polypeptide binding]; other site 862719000729 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719000730 putative CheW interface [polypeptide binding]; other site 862719000731 transcriptional regulator; Provisional; Region: PRK10632 862719000732 Helix-turn-helix domains; Region: HTH; cl00088 862719000733 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719000734 putative effector binding pocket; other site 862719000735 dimerization interface [polypeptide binding]; other site 862719000736 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 862719000737 Helix-turn-helix domains; Region: HTH; cl00088 862719000738 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000740 DNA-binding site [nucleotide binding]; DNA binding site 862719000741 FCD domain; Region: FCD; cl11656 862719000742 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 862719000743 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719000744 PYR/PP interface [polypeptide binding]; other site 862719000745 dimer interface [polypeptide binding]; other site 862719000746 TPP binding site [chemical binding]; other site 862719000747 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 862719000748 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 862719000749 TPP-binding site; other site 862719000750 dimer interface [polypeptide binding]; other site 862719000751 formyl-coenzyme A transferase; Provisional; Region: PRK05398 862719000752 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719000753 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 862719000754 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719000755 CoA-ligase; Region: Ligase_CoA; cl02894 862719000756 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 862719000757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000758 CoA-ligase; Region: Ligase_CoA; cl02894 862719000759 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719000760 Helix-turn-helix domains; Region: HTH; cl00088 862719000761 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000762 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 862719000763 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 862719000764 NAD(P) binding site [chemical binding]; other site 862719000765 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 862719000766 BON domain; Region: BON; cl02771 862719000767 BON domain; Region: BON; cl02771 862719000768 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 862719000769 active site 862719000770 metal binding site [ion binding]; metal-binding site 862719000771 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 862719000772 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 862719000773 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 862719000774 putative active site [active] 862719000775 putative substrate binding site [chemical binding]; other site 862719000776 putative cosubstrate binding site; other site 862719000777 catalytic site [active] 862719000778 two-component response regulator; Provisional; Region: PRK09191 862719000779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000780 active site 862719000781 phosphorylation site [posttranslational modification] 862719000782 intermolecular recognition site; other site 862719000783 dimerization interface [polypeptide binding]; other site 862719000784 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 862719000785 AMP-binding enzyme; Region: AMP-binding; cl15778 862719000786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719000787 YdjC-like protein; Region: YdjC; cl01344 862719000788 EamA-like transporter family; Region: EamA; cl01037 862719000789 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719000790 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 862719000791 peptide binding site [polypeptide binding]; other site 862719000792 dipeptide transporter permease DppB; Provisional; Region: PRK10914 862719000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000794 dimer interface [polypeptide binding]; other site 862719000795 conserved gate region; other site 862719000796 putative PBP binding loops; other site 862719000797 ABC-ATPase subunit interface; other site 862719000798 dipeptide transporter; Provisional; Region: PRK10913 862719000799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000800 putative PBP binding loops; other site 862719000801 dimer interface [polypeptide binding]; other site 862719000802 ABC-ATPase subunit interface; other site 862719000803 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 862719000804 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719000805 Walker A/P-loop; other site 862719000806 ATP binding site [chemical binding]; other site 862719000807 Q-loop/lid; other site 862719000808 ABC transporter signature motif; other site 862719000809 Walker B; other site 862719000810 D-loop; other site 862719000811 H-loop/switch region; other site 862719000812 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719000813 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862719000814 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719000815 Walker A/P-loop; other site 862719000816 ATP binding site [chemical binding]; other site 862719000817 Q-loop/lid; other site 862719000818 ABC transporter signature motif; other site 862719000819 Walker B; other site 862719000820 D-loop; other site 862719000821 H-loop/switch region; other site 862719000822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719000823 Protein of unknown function (DUF520); Region: DUF520; cl00723 862719000824 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 862719000825 tandem repeat interface [polypeptide binding]; other site 862719000826 oligomer interface [polypeptide binding]; other site 862719000827 active site residues [active] 862719000828 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 862719000829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000830 S-adenosylmethionine binding site [chemical binding]; other site 862719000831 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 862719000832 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 862719000833 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 862719000834 substrate binding pocket [chemical binding]; other site 862719000835 chain length determination region; other site 862719000836 substrate-Mg2+ binding site; other site 862719000837 catalytic residues [active] 862719000838 aspartate-rich region 1; other site 862719000839 active site lid residues [active] 862719000840 aspartate-rich region 2; other site 862719000841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719000842 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719000843 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 862719000844 active site 862719000845 metal binding site [ion binding]; metal-binding site 862719000846 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000847 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719000848 Predicted membrane protein [Function unknown]; Region: COG2860 862719000849 UPF0126 domain; Region: UPF0126; pfam03458 862719000850 UPF0126 domain; Region: UPF0126; pfam03458 862719000851 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719000852 metal-binding site [ion binding] 862719000853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862719000854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719000855 metal-binding site [ion binding] 862719000856 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719000857 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719000858 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 862719000859 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 862719000860 DNA binding residues [nucleotide binding] 862719000861 dimer interface [polypeptide binding]; other site 862719000862 copper binding site [ion binding]; other site 862719000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000864 putative substrate translocation pore; other site 862719000865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000866 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 862719000867 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719000868 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 862719000869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000870 S-adenosylmethionine binding site [chemical binding]; other site 862719000871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719000872 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 862719000873 hypothetical protein; Provisional; Region: PRK06034 862719000874 Chorismate mutase type II; Region: CM_2; cl00693 862719000875 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 862719000876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719000877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719000878 homodimer interface [polypeptide binding]; other site 862719000879 catalytic residue [active] 862719000880 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 862719000881 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 862719000882 cytosine deaminase; Validated; Region: PRK07572 862719000883 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 862719000884 active site 862719000885 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000886 TM-ABC transporter signature motif; other site 862719000887 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000888 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000889 TM-ABC transporter signature motif; other site 862719000890 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862719000891 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719000892 Walker A/P-loop; other site 862719000893 ATP binding site [chemical binding]; other site 862719000894 Q-loop/lid; other site 862719000895 ABC transporter signature motif; other site 862719000896 Walker B; other site 862719000897 D-loop; other site 862719000898 H-loop/switch region; other site 862719000899 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719000900 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719000901 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 862719000902 putative ligand binding site [chemical binding]; other site 862719000903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719000904 Helix-turn-helix domains; Region: HTH; cl00088 862719000905 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000906 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719000907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000908 Walker A/P-loop; other site 862719000909 ATP binding site [chemical binding]; other site 862719000910 Q-loop/lid; other site 862719000911 ABC transporter signature motif; other site 862719000912 Walker B; other site 862719000913 D-loop; other site 862719000914 H-loop/switch region; other site 862719000915 TOBE domain; Region: TOBE_2; cl01440 862719000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000917 dimer interface [polypeptide binding]; other site 862719000918 conserved gate region; other site 862719000919 putative PBP binding loops; other site 862719000920 ABC-ATPase subunit interface; other site 862719000921 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719000922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000923 dimer interface [polypeptide binding]; other site 862719000924 conserved gate region; other site 862719000925 putative PBP binding loops; other site 862719000926 ABC-ATPase subunit interface; other site 862719000927 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719000928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 862719000929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000930 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719000931 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719000932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719000934 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719000935 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719000936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719000937 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 862719000938 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 862719000939 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719000940 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719000941 ring oligomerisation interface [polypeptide binding]; other site 862719000942 ATP/Mg binding site [chemical binding]; other site 862719000943 stacking interactions; other site 862719000944 hinge regions; other site 862719000945 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 862719000946 oligomerisation interface [polypeptide binding]; other site 862719000947 mobile loop; other site 862719000948 roof hairpin; other site 862719000949 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719000950 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 862719000951 tetramer interface [polypeptide binding]; other site 862719000952 catalytic Zn binding site [ion binding]; other site 862719000953 NADP binding site [chemical binding]; other site 862719000954 putative oxidoreductase; Provisional; Region: PRK11579 862719000955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000956 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 862719000957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000958 dimer interface [polypeptide binding]; other site 862719000959 conserved gate region; other site 862719000960 putative PBP binding loops; other site 862719000961 ABC-ATPase subunit interface; other site 862719000962 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719000963 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719000964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719000965 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 862719000966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719000967 active site 862719000968 metal binding site [ion binding]; metal-binding site 862719000969 hexamer interface [polypeptide binding]; other site 862719000970 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719000971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719000972 Walker A/P-loop; other site 862719000973 ATP binding site [chemical binding]; other site 862719000974 Q-loop/lid; other site 862719000975 ABC transporter signature motif; other site 862719000976 Walker B; other site 862719000977 D-loop; other site 862719000978 H-loop/switch region; other site 862719000979 TOBE domain; Region: TOBE_2; cl01440 862719000980 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000982 dimer interface [polypeptide binding]; other site 862719000983 conserved gate region; other site 862719000984 putative PBP binding loops; other site 862719000985 ABC-ATPase subunit interface; other site 862719000986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000987 dimer interface [polypeptide binding]; other site 862719000988 conserved gate region; other site 862719000989 putative PBP binding loops; other site 862719000990 ABC-ATPase subunit interface; other site 862719000991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719000992 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719000993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719000994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719000995 DNA binding site [nucleotide binding] 862719000996 domain linker motif; other site 862719000997 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719000998 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719000999 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719001000 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719001001 Secretin and TonB N terminus short domain; Region: STN; cl06624 862719001002 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719001003 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719001004 N-terminal plug; other site 862719001005 ligand-binding site [chemical binding]; other site 862719001006 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719001007 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719001008 FecR protein; Region: FecR; pfam04773 862719001009 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862719001010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719001011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719001012 DNA binding residues [nucleotide binding] 862719001013 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719001014 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 862719001015 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 862719001016 glutaminase active site [active] 862719001017 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 862719001018 dimer interface [polypeptide binding]; other site 862719001019 active site 862719001020 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 862719001021 dimer interface [polypeptide binding]; other site 862719001022 active site 862719001023 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 862719001024 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 862719001025 Substrate binding site; other site 862719001026 Mg++ binding site; other site 862719001027 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 862719001028 active site 862719001029 substrate binding site [chemical binding]; other site 862719001030 CoA binding site [chemical binding]; other site 862719001031 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 862719001032 active site 862719001033 catalytic residues [active] 862719001034 DNA binding site [nucleotide binding] 862719001035 Int/Topo IB signature motif; other site 862719001036 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719001037 DnaA N-terminal domain; Region: DnaA_N; pfam11638 862719001038 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 862719001039 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719001040 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 862719001041 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 862719001042 mismatch recognition site; other site 862719001043 additional DNA contacts [nucleotide binding]; other site 862719001044 active site 862719001045 zinc binding site [ion binding]; other site 862719001046 DNA intercalation site [nucleotide binding]; other site 862719001047 Protein of unknown function DUF262; Region: DUF262; cl14890 862719001048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719001049 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 862719001050 cofactor binding site; other site 862719001051 DNA binding site [nucleotide binding] 862719001052 substrate interaction site [chemical binding]; other site 862719001053 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 862719001054 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719001055 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 862719001056 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719001057 active site 862719001058 DNA binding site [nucleotide binding] 862719001059 Int/Topo IB signature motif; other site 862719001060 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 862719001061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001062 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 862719001063 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 862719001064 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719001065 gpW; Region: gpW; pfam02831 862719001066 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719001067 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 862719001068 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 862719001069 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 862719001070 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 862719001071 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719001072 catalytic residue [active] 862719001073 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 862719001074 pantoate--beta-alanine ligase; Region: panC; TIGR00018 862719001075 Pantoate-beta-alanine ligase; Region: PanC; cd00560 862719001076 active site 862719001077 ATP-binding site [chemical binding]; other site 862719001078 pantoate-binding site; other site 862719001079 HXXH motif; other site 862719001080 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719001081 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 862719001082 muropeptide transporter; Validated; Region: ampG; PRK11010 862719001083 muropeptide transporter; Reviewed; Region: ampG; PRK11902 862719001084 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 862719001085 dimanganese center [ion binding]; other site 862719001086 glutathione reductase; Validated; Region: PRK06116 862719001087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719001088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719001089 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719001090 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 862719001091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719001092 active site 862719001093 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 862719001094 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719001095 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719001096 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 862719001097 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862719001098 intersubunit interface [polypeptide binding]; other site 862719001099 active site 862719001100 catalytic residue [active] 862719001101 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862719001102 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 862719001103 active site 862719001104 catalytic motif [active] 862719001105 Zn binding site [ion binding]; other site 862719001106 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719001107 TM-ABC transporter signature motif; other site 862719001108 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719001109 TM-ABC transporter signature motif; other site 862719001110 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719001111 dimer interface [polypeptide binding]; other site 862719001112 [2Fe-2S] cluster binding site [ion binding]; other site 862719001113 EamA-like transporter family; Region: EamA; cl01037 862719001114 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001115 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719001116 ligand binding site [chemical binding]; other site 862719001117 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001118 TM-ABC transporter signature motif; other site 862719001119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001120 TM-ABC transporter signature motif; other site 862719001121 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001123 Walker A/P-loop; other site 862719001124 ATP binding site [chemical binding]; other site 862719001125 Q-loop/lid; other site 862719001126 ABC transporter signature motif; other site 862719001127 Walker B; other site 862719001128 D-loop; other site 862719001129 H-loop/switch region; other site 862719001130 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001131 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719001132 Walker A/P-loop; other site 862719001133 ATP binding site [chemical binding]; other site 862719001134 Q-loop/lid; other site 862719001135 ABC transporter signature motif; other site 862719001136 Walker B; other site 862719001137 D-loop; other site 862719001138 H-loop/switch region; other site 862719001139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001140 dimer interface [polypeptide binding]; other site 862719001141 conserved gate region; other site 862719001142 putative PBP binding loops; other site 862719001143 ABC-ATPase subunit interface; other site 862719001144 NMT1/THI5 like; Region: NMT1; pfam09084 862719001145 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719001146 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719001147 Walker A/P-loop; other site 862719001148 ATP binding site [chemical binding]; other site 862719001149 Q-loop/lid; other site 862719001150 ABC transporter signature motif; other site 862719001151 Walker B; other site 862719001152 D-loop; other site 862719001153 H-loop/switch region; other site 862719001154 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719001155 metal binding site [ion binding]; metal-binding site 862719001156 substrate binding pocket [chemical binding]; other site 862719001157 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719001158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 862719001160 Protein of unknown function (DUF993); Region: DUF993; pfam06187 862719001161 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 862719001162 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 862719001163 Helix-turn-helix domains; Region: HTH; cl00088 862719001164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719001165 Ligand Binding Site [chemical binding]; other site 862719001166 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001168 active site 862719001169 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719001170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001171 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 862719001172 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719001173 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719001174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001175 substrate binding site [chemical binding]; other site 862719001176 oxyanion hole (OAH) forming residues; other site 862719001177 trimer interface [polypeptide binding]; other site 862719001178 acyl-CoA synthetase; Validated; Region: PRK08316 862719001179 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719001181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719001182 Helix-turn-helix domains; Region: HTH; cl00088 862719001183 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 862719001184 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001185 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 862719001186 putative ligand binding site [chemical binding]; other site 862719001187 Helix-turn-helix domains; Region: HTH; cl00088 862719001188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719001189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001190 NAD(P) binding site [chemical binding]; other site 862719001191 active site 862719001192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001194 active site 862719001195 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 862719001196 putative active site [active] 862719001197 putative substrate binding site [chemical binding]; other site 862719001198 ATP binding site [chemical binding]; other site 862719001199 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001200 catalytic core [active] 862719001201 pyruvate kinase; Provisional; Region: PRK06247 862719001202 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719001203 domain interfaces; other site 862719001204 active site 862719001205 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 862719001206 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 862719001207 active site 862719001208 catalytic residues [active] 862719001209 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 862719001210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719001211 motif II; other site 862719001212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719001213 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719001214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001215 dimer interface [polypeptide binding]; other site 862719001216 conserved gate region; other site 862719001217 putative PBP binding loops; other site 862719001218 ABC-ATPase subunit interface; other site 862719001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001220 dimer interface [polypeptide binding]; other site 862719001221 conserved gate region; other site 862719001222 putative PBP binding loops; other site 862719001223 ABC-ATPase subunit interface; other site 862719001224 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 862719001225 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 862719001226 Walker A/P-loop; other site 862719001227 ATP binding site [chemical binding]; other site 862719001228 Q-loop/lid; other site 862719001229 ABC transporter signature motif; other site 862719001230 Walker B; other site 862719001231 D-loop; other site 862719001232 H-loop/switch region; other site 862719001233 TOBE-like domain; Region: TOBE_3; pfam12857 862719001234 putative cation:proton antiport protein; Provisional; Region: PRK10669 862719001235 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862719001236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001237 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719001238 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 862719001239 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719001240 Ligand Binding Site [chemical binding]; other site 862719001241 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 862719001242 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719001243 active site 862719001244 dimer interface [polypeptide binding]; other site 862719001245 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719001246 Ligand Binding Site [chemical binding]; other site 862719001247 Molecular Tunnel; other site 862719001248 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 862719001249 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719001251 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719001252 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 862719001253 putative active site [active] 862719001254 putative metal binding site [ion binding]; other site 862719001255 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719001256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719001257 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719001258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719001259 active site 862719001260 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 862719001261 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 862719001262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001263 Bacterial sugar transferase; Region: Bac_transf; cl00939 862719001264 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719001265 trimer interface [polypeptide binding]; other site 862719001266 active site 862719001267 substrate binding site [chemical binding]; other site 862719001268 CoA binding site [chemical binding]; other site 862719001269 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 862719001270 Calx-beta domain; Region: Calx-beta; cl02522 862719001271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719001272 S-adenosylmethionine binding site [chemical binding]; other site 862719001273 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 862719001274 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 862719001275 Chain length determinant protein; Region: Wzz; cl15801 862719001276 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 862719001277 Chain length determinant protein; Region: Wzz; cl15801 862719001278 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 862719001279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719001281 nucleotide binding region [chemical binding]; other site 862719001282 ATP-binding site [chemical binding]; other site 862719001283 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 862719001284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001285 catalytic core [active] 862719001286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001287 Helix-turn-helix domains; Region: HTH; cl00088 862719001288 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 862719001289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719001290 dimer interface [polypeptide binding]; other site 862719001291 phosphorylation site [posttranslational modification] 862719001292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001293 ATP binding site [chemical binding]; other site 862719001294 Mg2+ binding site [ion binding]; other site 862719001295 G-X-G motif; other site 862719001296 Response regulator receiver domain; Region: Response_reg; pfam00072 862719001297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001298 active site 862719001299 phosphorylation site [posttranslational modification] 862719001300 intermolecular recognition site; other site 862719001301 dimerization interface [polypeptide binding]; other site 862719001302 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719001303 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001304 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001305 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719001306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001309 pseudaminic acid synthase; Region: PseI; TIGR03586 862719001310 NeuB family; Region: NeuB; cl00496 862719001311 SAF domain; Region: SAF; cl00555 862719001312 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 862719001313 ligand binding site; other site 862719001314 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 862719001315 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 862719001316 nucleophilic elbow; other site 862719001317 catalytic triad; other site 862719001318 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719001319 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719001321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001322 NAD(P) binding site [chemical binding]; other site 862719001323 active site 862719001324 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719001325 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 862719001326 dimer interface [polypeptide binding]; other site 862719001327 active site 862719001328 CoA binding pocket [chemical binding]; other site 862719001329 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719001330 flagellin; Reviewed; Region: PRK12688 862719001331 Flagellar protein FlbT; Region: FlbT; cl11455 862719001332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001333 binding surface 862719001334 TPR motif; other site 862719001335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001336 binding surface 862719001337 TPR motif; other site 862719001338 TPR repeat; Region: TPR_11; pfam13414 862719001339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001340 binding surface 862719001341 TPR motif; other site 862719001342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001343 binding surface 862719001344 TPR motif; other site 862719001345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001346 binding surface 862719001347 TPR motif; other site 862719001348 TPR repeat; Region: TPR_11; pfam13414 862719001349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001350 binding surface 862719001351 TPR motif; other site 862719001352 TPR repeat; Region: TPR_11; pfam13414 862719001353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001354 binding surface 862719001355 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719001356 TPR motif; other site 862719001357 Protein of unknown function (DUF465); Region: DUF465; cl01070 862719001358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001359 binding surface 862719001360 TPR motif; other site 862719001361 TPR repeat; Region: TPR_11; pfam13414 862719001362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719001363 binding surface 862719001364 TPR motif; other site 862719001365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001366 binding surface 862719001367 TPR motif; other site 862719001368 TPR repeat; Region: TPR_11; pfam13414 862719001369 TPR repeat; Region: TPR_11; pfam13414 862719001370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001371 binding surface 862719001372 TPR motif; other site 862719001373 TPR repeat; Region: TPR_11; pfam13414 862719001374 TPR repeat; Region: TPR_11; pfam13414 862719001375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001376 binding surface 862719001377 TPR motif; other site 862719001378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001380 TPR motif; other site 862719001381 TPR repeat; Region: TPR_11; pfam13414 862719001382 binding surface 862719001383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001384 binding surface 862719001385 TPR motif; other site 862719001386 TPR repeat; Region: TPR_11; pfam13414 862719001387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001390 binding surface 862719001391 TPR motif; other site 862719001392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001393 binding surface 862719001394 TPR motif; other site 862719001395 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 862719001396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719001397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001398 TPR motif; other site 862719001399 binding surface 862719001400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001401 binding surface 862719001402 TPR motif; other site 862719001403 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 862719001404 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719001405 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 862719001406 Protein phosphatase 2C; Region: PP2C; pfam00481 862719001407 active site 862719001408 Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642 862719001409 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719001410 ATP binding site [chemical binding]; other site 862719001411 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 862719001412 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 862719001413 active site 862719001414 catalytic site [active] 862719001415 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719001416 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719001417 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719001418 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 862719001419 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719001420 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 862719001421 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719001422 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719001423 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719001424 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719001425 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 862719001426 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719001427 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719001428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001429 TPR motif; other site 862719001430 TPR repeat; Region: TPR_11; pfam13414 862719001431 binding surface 862719001432 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719001433 ADP-heptose:LPS heptosyltransferase II; Provisional; Region: PRK10916; cl15782 862719001434 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 862719001435 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 862719001436 PAS domain S-box; Region: sensory_box; TIGR00229 862719001437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719001438 putative active site [active] 862719001439 heme pocket [chemical binding]; other site 862719001440 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719001441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001442 ATP binding site [chemical binding]; other site 862719001443 Mg2+ binding site [ion binding]; other site 862719001444 G-X-G motif; other site 862719001445 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719001446 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862719001447 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719001448 active site 862719001449 metal binding site [ion binding]; metal-binding site 862719001450 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719001451 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 862719001452 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719001453 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 862719001454 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 862719001455 C-terminal domain interface [polypeptide binding]; other site 862719001456 GSH binding site (G-site) [chemical binding]; other site 862719001457 dimer interface [polypeptide binding]; other site 862719001458 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 862719001459 N-terminal domain interface [polypeptide binding]; other site 862719001460 putative dimer interface [polypeptide binding]; other site 862719001461 active site 862719001462 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001464 active site 862719001465 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 862719001466 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001467 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001468 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719001469 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001470 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001471 TM-ABC transporter signature motif; other site 862719001472 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001473 TM-ABC transporter signature motif; other site 862719001474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001475 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719001476 Walker A/P-loop; other site 862719001477 ATP binding site [chemical binding]; other site 862719001478 Q-loop/lid; other site 862719001479 ABC transporter signature motif; other site 862719001480 Walker B; other site 862719001481 D-loop; other site 862719001482 H-loop/switch region; other site 862719001483 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001484 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719001485 Walker A/P-loop; other site 862719001486 ATP binding site [chemical binding]; other site 862719001487 Q-loop/lid; other site 862719001488 ABC transporter signature motif; other site 862719001489 Walker B; other site 862719001490 D-loop; other site 862719001491 H-loop/switch region; other site 862719001492 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719001493 CoenzymeA binding site [chemical binding]; other site 862719001494 subunit interaction site [polypeptide binding]; other site 862719001495 PHB binding site; other site 862719001496 enoyl-CoA hydratase; Provisional; Region: PRK07511 862719001497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001498 substrate binding site [chemical binding]; other site 862719001499 oxyanion hole (OAH) forming residues; other site 862719001500 trimer interface [polypeptide binding]; other site 862719001501 Response regulator receiver domain; Region: Response_reg; pfam00072 862719001502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001503 active site 862719001504 phosphorylation site [posttranslational modification] 862719001505 intermolecular recognition site; other site 862719001506 dimerization interface [polypeptide binding]; other site 862719001507 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 862719001508 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719001509 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 862719001510 active site 862719001511 catalytic site [active] 862719001512 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 862719001513 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 862719001514 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 862719001515 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 862719001516 catalytic site [active] 862719001517 active site 862719001518 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 862719001519 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 862719001520 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 862719001521 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719001522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001523 active site 862719001524 phosphorylation site [posttranslational modification] 862719001525 intermolecular recognition site; other site 862719001526 dimerization interface [polypeptide binding]; other site 862719001527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001528 Walker A motif; other site 862719001529 ATP binding site [chemical binding]; other site 862719001530 Walker B motif; other site 862719001531 arginine finger; other site 862719001532 Helix-turn-helix domains; Region: HTH; cl00088 862719001533 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719001534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719001535 dimer interface [polypeptide binding]; other site 862719001536 phosphorylation site [posttranslational modification] 862719001537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001538 ATP binding site [chemical binding]; other site 862719001539 Mg2+ binding site [ion binding]; other site 862719001540 G-X-G motif; other site 862719001541 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 862719001542 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 862719001543 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 862719001544 Malic enzyme, N-terminal domain; Region: malic; pfam00390 862719001545 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 862719001546 putative NAD(P) binding site [chemical binding]; other site 862719001547 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862719001548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001549 binding surface 862719001550 TPR motif; other site 862719001551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001552 binding surface 862719001553 TPR motif; other site 862719001554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001556 binding surface 862719001557 TPR motif; other site 862719001558 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719001559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001560 TPR motif; other site 862719001561 binding surface 862719001562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001563 binding surface 862719001564 TPR motif; other site 862719001565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001567 binding surface 862719001568 TPR motif; other site 862719001569 TPR repeat; Region: TPR_11; pfam13414 862719001570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001571 binding surface 862719001572 TPR motif; other site 862719001573 TPR repeat; Region: TPR_11; pfam13414 862719001574 TPR repeat; Region: TPR_11; pfam13414 862719001575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001576 binding surface 862719001577 TPR motif; other site 862719001578 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719001579 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 862719001580 Substrate binding site; other site 862719001581 Mg++ binding site; other site 862719001582 metal-binding site 862719001583 Mg++ binding site; other site 862719001584 metal-binding site 862719001585 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 862719001586 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 862719001587 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719001588 acetyl-CoA synthetase; Provisional; Region: PRK04319 862719001589 AMP-binding enzyme; Region: AMP-binding; cl15778 862719001590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719001591 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 862719001592 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001593 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719001594 Walker A/P-loop; other site 862719001595 ATP binding site [chemical binding]; other site 862719001596 Q-loop/lid; other site 862719001597 ABC transporter signature motif; other site 862719001598 Walker B; other site 862719001599 D-loop; other site 862719001600 H-loop/switch region; other site 862719001601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001602 binding surface 862719001603 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719001604 TPR motif; other site 862719001605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719001606 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719001607 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001608 TM-ABC transporter signature motif; other site 862719001609 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001610 TM-ABC transporter signature motif; other site 862719001611 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001612 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719001613 Walker A/P-loop; other site 862719001614 ATP binding site [chemical binding]; other site 862719001615 Q-loop/lid; other site 862719001616 ABC transporter signature motif; other site 862719001617 Walker B; other site 862719001618 D-loop; other site 862719001619 H-loop/switch region; other site 862719001620 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 862719001621 active site 862719001622 catalytic residues [active] 862719001623 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 862719001624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719001625 metal binding site [ion binding]; metal-binding site 862719001626 active site 862719001627 I-site; other site 862719001628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719001629 Helix-turn-helix domains; Region: HTH; cl00088 862719001630 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719001631 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 862719001632 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001633 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001634 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 862719001635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001636 putative substrate translocation pore; other site 862719001637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001638 homoserine O-acetyltransferase; Provisional; Region: PRK06765 862719001639 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719001640 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 862719001641 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 862719001642 LysE type translocator; Region: LysE; cl00565 862719001643 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 862719001644 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 862719001645 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 862719001646 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 862719001647 RNA binding site [nucleotide binding]; other site 862719001648 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 862719001649 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862719001650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719001651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719001652 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 862719001653 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 862719001654 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 862719001655 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 862719001656 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 862719001657 DXD motif; other site 862719001658 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 862719001659 putative acyl-acceptor binding pocket; other site 862719001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001661 phytoene desaturase; Region: crtI_fam; TIGR02734 862719001662 phytoene desaturase; Region: crtI_fam; TIGR02734 862719001663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001664 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 862719001665 NAD(P) binding site [chemical binding]; other site 862719001666 catalytic residues [active] 862719001667 Predicted membrane protein [Function unknown]; Region: COG3918 862719001668 beta-ketothiolase; Provisional; Region: PRK09051 862719001669 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719001670 dimer interface [polypeptide binding]; other site 862719001671 active site 862719001672 enoyl-CoA hydratase; Provisional; Region: PRK06688 862719001673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001674 substrate binding site [chemical binding]; other site 862719001675 oxyanion hole (OAH) forming residues; other site 862719001676 trimer interface [polypeptide binding]; other site 862719001677 putative MFS family transporter protein; Provisional; Region: PRK03633 862719001678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001679 putative substrate translocation pore; other site 862719001680 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719001681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719001682 classical (c) SDRs; Region: SDR_c; cd05233 862719001683 NAD(P) binding site [chemical binding]; other site 862719001684 active site 862719001685 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 862719001686 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 862719001687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719001688 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 862719001689 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 862719001690 trimer interface I [polypeptide binding]; other site 862719001691 putative substrate binding pocket [chemical binding]; other site 862719001692 trimer interface II [polypeptide binding]; other site 862719001693 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 862719001694 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 862719001695 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 862719001696 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719001697 molybdopterin cofactor binding site; other site 862719001698 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 862719001699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719001700 active site 862719001701 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 862719001702 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 862719001703 FTR, proximal lobe; Region: FTR_C; pfam02741 862719001704 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 862719001705 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001706 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719001707 ligand binding site [chemical binding]; other site 862719001708 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 862719001709 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 862719001710 structural tetrad; other site 862719001711 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719001712 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 862719001713 PqqA family; Region: PqqA; cl15372 862719001714 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 862719001715 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862719001716 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719001717 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719001718 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 862719001719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001720 Walker A/P-loop; other site 862719001721 ATP binding site [chemical binding]; other site 862719001722 Q-loop/lid; other site 862719001723 ABC transporter signature motif; other site 862719001724 Walker B; other site 862719001725 D-loop; other site 862719001726 H-loop/switch region; other site 862719001727 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719001728 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719001729 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 862719001730 Trp docking motif [polypeptide binding]; other site 862719001731 dimer interface [polypeptide binding]; other site 862719001732 active site 862719001733 small subunit binding site [polypeptide binding]; other site 862719001734 Cytochrome c; Region: Cytochrom_C; cl11414 862719001735 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 862719001736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719001737 substrate binding pocket [chemical binding]; other site 862719001738 membrane-bound complex binding site; other site 862719001739 hinge residues; other site 862719001740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719001741 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 862719001742 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 862719001743 dihydropteroate synthase-related protein; Region: TIGR00284 862719001744 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862719001745 substrate binding pocket [chemical binding]; other site 862719001746 dimer interface [polypeptide binding]; other site 862719001747 inhibitor binding site; inhibition site 862719001748 Flavin Reductases; Region: FlaRed; cl00801 862719001749 Protein of unknown function (DUF556); Region: DUF556; cl00822 862719001750 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 862719001751 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719001752 catalytic loop [active] 862719001753 iron binding site [ion binding]; other site 862719001754 4Fe-4S binding domain; Region: Fer4; cl02805 862719001755 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719001756 [4Fe-4S] binding site [ion binding]; other site 862719001757 molybdopterin cofactor binding site; other site 862719001758 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 862719001759 molybdopterin cofactor binding site; other site 862719001760 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 862719001761 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 862719001762 putative dimer interface [polypeptide binding]; other site 862719001763 [2Fe-2S] cluster binding site [ion binding]; other site 862719001764 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 862719001765 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 862719001766 SLBB domain; Region: SLBB; pfam10531 862719001767 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 862719001768 phosphoglycolate phosphatase; Provisional; Region: PRK13222 862719001769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719001770 motif II; other site 862719001771 hypothetical protein; Provisional; Region: PRK08185 862719001772 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 862719001773 intersubunit interface [polypeptide binding]; other site 862719001774 active site 862719001775 zinc binding site [ion binding]; other site 862719001776 Na+ binding site [ion binding]; other site 862719001777 transketolase; Reviewed; Region: PRK12753 862719001778 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719001779 TPP-binding site [chemical binding]; other site 862719001780 dimer interface [polypeptide binding]; other site 862719001781 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719001782 PYR/PP interface [polypeptide binding]; other site 862719001783 dimer interface [polypeptide binding]; other site 862719001784 TPP binding site [chemical binding]; other site 862719001785 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719001786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001787 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 862719001788 AMP binding site [chemical binding]; other site 862719001789 metal binding site [ion binding]; metal-binding site 862719001790 active site 862719001791 CbbX; Provisional; Region: cbbX; CHL00181 862719001792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001793 Walker A motif; other site 862719001794 ATP binding site [chemical binding]; other site 862719001795 Walker B motif; other site 862719001796 arginine finger; other site 862719001797 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 862719001798 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862719001799 substrate binding site [chemical binding]; other site 862719001800 hexamer interface [polypeptide binding]; other site 862719001801 metal binding site [ion binding]; metal-binding site 862719001802 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 862719001803 multimerization interface [polypeptide binding]; other site 862719001804 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 862719001805 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 862719001806 homodimer interface [polypeptide binding]; other site 862719001807 active site 862719001808 heterodimer interface [polypeptide binding]; other site 862719001809 catalytic residue [active] 862719001810 metal binding site [ion binding]; metal-binding site 862719001811 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 862719001812 Helix-turn-helix domains; Region: HTH; cl00088 862719001813 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 862719001814 putative dimerization interface [polypeptide binding]; other site 862719001815 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719001816 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 862719001817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001818 Walker A motif; other site 862719001819 ATP binding site [chemical binding]; other site 862719001820 Walker B motif; other site 862719001821 arginine finger; other site 862719001822 Helix-turn-helix domains; Region: HTH; cl00088 862719001823 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719001824 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719001825 ring oligomerisation interface [polypeptide binding]; other site 862719001826 ATP/Mg binding site [chemical binding]; other site 862719001827 stacking interactions; other site 862719001828 hinge regions; other site 862719001829 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 862719001830 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 862719001831 dimerization interface [polypeptide binding]; other site 862719001832 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 862719001833 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719001834 catalytic loop [active] 862719001835 iron binding site [ion binding]; other site 862719001836 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 862719001837 FAD binding pocket [chemical binding]; other site 862719001838 FAD binding motif [chemical binding]; other site 862719001839 phosphate binding motif [ion binding]; other site 862719001840 beta-alpha-beta structure motif; other site 862719001841 NAD binding pocket [chemical binding]; other site 862719001842 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 862719001843 dimerization interface [polypeptide binding]; other site 862719001844 putative path to active site cavity [active] 862719001845 diiron center [ion binding]; other site 862719001846 Cytochrome c; Region: Cytochrom_C; cl11414 862719001847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719001848 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 862719001849 dimer interface [polypeptide binding]; other site 862719001850 active site 862719001851 metal binding site [ion binding]; metal-binding site 862719001852 glutathione binding site [chemical binding]; other site 862719001853 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 862719001854 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719001855 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719001856 exonuclease subunit SbcD; Provisional; Region: PRK10966 862719001857 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 862719001858 active site 862719001859 metal binding site [ion binding]; metal-binding site 862719001860 DNA binding site [nucleotide binding] 862719001861 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 862719001862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001863 Walker A/P-loop; other site 862719001864 ATP binding site [chemical binding]; other site 862719001865 Q-loop/lid; other site 862719001866 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862719001867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719001868 Q-loop/lid; other site 862719001869 ABC transporter signature motif; other site 862719001870 Walker B; other site 862719001871 D-loop; other site 862719001872 H-loop/switch region; other site 862719001873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001874 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719001875 Walker A motif; other site 862719001876 ATP binding site [chemical binding]; other site 862719001877 Walker B motif; other site 862719001878 arginine finger; other site 862719001879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719001880 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 862719001881 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719001882 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719001883 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 862719001884 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719001885 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862719001886 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 862719001887 motif 1; other site 862719001888 active site 862719001889 motif 2; other site 862719001890 motif 3; other site 862719001891 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 862719001892 DHHA1 domain; Region: DHHA1; pfam02272 862719001893 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 862719001894 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 862719001895 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 862719001896 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 862719001897 ScpA/B protein; Region: ScpA_ScpB; cl00598 862719001898 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 862719001899 active site 862719001900 putative substrate binding region [chemical binding]; other site 862719001901 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 862719001902 Sporulation related domain; Region: SPOR; cl10051 862719001903 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 862719001904 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 862719001905 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 862719001906 active site 862719001907 HIGH motif; other site 862719001908 KMSK motif region; other site 862719001909 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719001910 tRNA binding surface [nucleotide binding]; other site 862719001911 anticodon binding site; other site 862719001912 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 862719001913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719001914 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 862719001915 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 862719001916 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 862719001917 putative catalytic site [active] 862719001918 putative phosphate binding site [ion binding]; other site 862719001919 active site 862719001920 metal binding site A [ion binding]; metal-binding site 862719001921 DNA binding site [nucleotide binding] 862719001922 putative AP binding site [nucleotide binding]; other site 862719001923 putative metal binding site B [ion binding]; other site 862719001924 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 862719001925 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719001926 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719001927 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719001928 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 862719001929 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719001930 integrase; Provisional; Region: PRK09692 862719001931 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 862719001932 active site 862719001933 Int/Topo IB signature motif; other site 862719001934 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 862719001935 aminopeptidase N; Provisional; Region: pepN; PRK14015 862719001936 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 862719001937 active site 862719001938 Zn binding site [ion binding]; other site 862719001939 Cytochrome c; Region: Cytochrom_C; cl11414 862719001940 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 862719001941 putative hydrophobic ligand binding site [chemical binding]; other site 862719001942 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 862719001943 catalytic center binding site [active] 862719001944 ATP binding site [chemical binding]; other site 862719001945 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 862719001946 Response regulator receiver domain; Region: Response_reg; pfam00072 862719001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001948 active site 862719001949 phosphorylation site [posttranslational modification] 862719001950 intermolecular recognition site; other site 862719001951 dimerization interface [polypeptide binding]; other site 862719001952 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 862719001953 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719001954 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001955 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719001957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719001958 active site 862719001959 Clp protease; Region: CLP_protease; pfam00574 862719001960 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 862719001961 oligomer interface [polypeptide binding]; other site 862719001962 active site residues [active] 862719001963 OpgC protein; Region: OpgC_C; cl00792 862719001964 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 862719001965 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719001966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719001967 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719001968 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719001969 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719001970 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001971 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719001972 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 862719001973 Cytochrome c; Region: Cytochrom_C; cl11414 862719001974 Cytochrome c; Region: Cytochrom_C; cl11414 862719001975 Cytochrome c; Region: Cytochrom_C; cl11414 862719001976 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719001977 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 862719001978 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 862719001979 D-pathway; other site 862719001980 Low-spin heme binding site [chemical binding]; other site 862719001981 Putative water exit pathway; other site 862719001982 Binuclear center (active site) [active] 862719001983 K-pathway; other site 862719001984 Putative proton exit pathway; other site 862719001985 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 862719001986 Subunit I/III interface [polypeptide binding]; other site 862719001987 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 862719001988 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719001989 Cytochrome c; Region: Cytochrom_C; cl11414 862719001990 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 862719001991 TIGR02588 family protein; Region: TIGR02588 862719001992 transcriptional regulator; Provisional; Region: PRK10632 862719001993 Helix-turn-helix domains; Region: HTH; cl00088 862719001994 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 862719001995 putative effector binding pocket; other site 862719001996 putative dimerization interface [polypeptide binding]; other site 862719001997 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719001998 ligand binding site [chemical binding]; other site 862719001999 flexible hinge region; other site 862719002000 CAAX protease self-immunity; Region: Abi; cl00558 862719002001 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 862719002002 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 862719002003 active site 862719002004 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 862719002005 active site 862719002006 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719002007 Acyl transferase domain; Region: Acyl_transf_1; cl08282 862719002008 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002009 active site 2 [active] 862719002010 active site 1 [active] 862719002011 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 862719002012 active site 1 [active] 862719002013 dimer interface [polypeptide binding]; other site 862719002014 active site 2 [active] 862719002015 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002016 active site 2 [active] 862719002017 active site 1 [active] 862719002018 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002019 active site 2 [active] 862719002020 active site 1 [active] 862719002021 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862719002022 putative acyl-acceptor binding pocket; other site 862719002023 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 862719002024 active site 862719002025 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719002026 Acyl transferase domain; Region: Acyl_transf_1; cl08282 862719002027 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002028 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002029 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 862719002030 putative NADP binding site [chemical binding]; other site 862719002031 active site 862719002032 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719002033 phosphate binding site [ion binding]; other site 862719002034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719002035 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 862719002036 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719002037 putative metal binding site [ion binding]; other site 862719002038 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 862719002039 Cl- selectivity filter; other site 862719002040 Cl- binding residues [ion binding]; other site 862719002041 pore gating glutamate residue; other site 862719002042 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 862719002043 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719002044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002045 Helix-turn-helix domains; Region: HTH; cl00088 862719002046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002047 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 862719002048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719002049 inhibitor-cofactor binding pocket; inhibition site 862719002050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719002051 catalytic residue [active] 862719002052 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 862719002053 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002054 tetrameric interface [polypeptide binding]; other site 862719002055 NAD binding site [chemical binding]; other site 862719002056 catalytic residues [active] 862719002057 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 862719002058 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 862719002059 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 862719002060 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862719002061 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862719002062 dimer interface [polypeptide binding]; other site 862719002063 active site 862719002064 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862719002065 folate binding site [chemical binding]; other site 862719002066 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 862719002067 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 862719002068 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719002069 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 862719002070 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 862719002071 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 862719002072 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002073 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002074 conserved cys residue [active] 862719002075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002076 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 862719002077 Uncharacterized conserved protein [Function unknown]; Region: COG3760 862719002078 putative deacylase active site [active] 862719002079 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 862719002080 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 862719002081 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 862719002082 putative active site [active] 862719002083 putative substrate binding site [chemical binding]; other site 862719002084 putative cosubstrate binding site; other site 862719002085 catalytic site [active] 862719002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002087 putative substrate translocation pore; other site 862719002088 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 862719002089 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719002090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002091 Walker A/P-loop; other site 862719002092 ATP binding site [chemical binding]; other site 862719002093 Q-loop/lid; other site 862719002094 ABC transporter signature motif; other site 862719002095 Walker B; other site 862719002096 D-loop; other site 862719002097 H-loop/switch region; other site 862719002098 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719002099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719002100 dimer interface [polypeptide binding]; other site 862719002101 putative CheW interface [polypeptide binding]; other site 862719002102 NMT1-like family; Region: NMT1_2; cl15260 862719002103 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 862719002104 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719002105 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719002106 [2Fe-2S] cluster binding site [ion binding]; other site 862719002107 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 862719002108 putative alpha subunit interface [polypeptide binding]; other site 862719002109 putative active site [active] 862719002110 putative substrate binding site [chemical binding]; other site 862719002111 Fe binding site [ion binding]; other site 862719002112 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 862719002113 FAD binding pocket [chemical binding]; other site 862719002114 FAD binding motif [chemical binding]; other site 862719002115 phosphate binding motif [ion binding]; other site 862719002116 beta-alpha-beta structure motif; other site 862719002117 NAD binding pocket [chemical binding]; other site 862719002118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719002119 catalytic loop [active] 862719002120 iron binding site [ion binding]; other site 862719002121 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002122 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002123 conserved cys residue [active] 862719002124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002125 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 862719002126 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 862719002127 putative active site [active] 862719002128 putative FMN binding site [chemical binding]; other site 862719002129 putative substrate binding site [chemical binding]; other site 862719002130 putative catalytic residue [active] 862719002131 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 862719002132 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862719002133 4Fe-4S binding domain; Region: Fer4; cl02805 862719002134 Cysteine-rich domain; Region: CCG; pfam02754 862719002135 Cysteine-rich domain; Region: CCG; pfam02754 862719002136 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719002137 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719002138 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719002139 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719002140 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 862719002141 Walker A/P-loop; other site 862719002142 ATP binding site [chemical binding]; other site 862719002143 Q-loop/lid; other site 862719002144 ABC transporter signature motif; other site 862719002145 Walker B; other site 862719002146 D-loop; other site 862719002147 H-loop/switch region; other site 862719002148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 862719002149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002150 dimer interface [polypeptide binding]; other site 862719002151 conserved gate region; other site 862719002152 putative PBP binding loops; other site 862719002153 ABC-ATPase subunit interface; other site 862719002154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719002155 Coenzyme A binding pocket [chemical binding]; other site 862719002156 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 862719002157 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719002158 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719002159 transcription elongation factor regulatory protein; Validated; Region: PRK06342 862719002160 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719002161 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 862719002162 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 862719002163 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719002164 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719002165 phosphate binding site [ion binding]; other site 862719002166 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 862719002167 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 862719002168 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862719002169 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719002170 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 862719002171 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 862719002172 trimer interface I [polypeptide binding]; other site 862719002173 putative substrate binding pocket [chemical binding]; other site 862719002174 trimer interface II [polypeptide binding]; other site 862719002175 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 862719002176 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719002177 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 862719002178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002179 NAD(P) binding pocket [chemical binding]; other site 862719002180 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 862719002181 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 862719002182 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 862719002183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719002184 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 862719002185 molybdopterin cofactor binding site; other site 862719002186 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 862719002187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719002188 active site 862719002189 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 862719002190 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 862719002191 FTR, proximal lobe; Region: FTR_C; pfam02741 862719002192 Formylmethanofuran dehydrogenase subunit C [Energy production and conversion]; Region: FwdC; COG2218 862719002193 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 862719002194 domain_subunit interface; other site 862719002195 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002196 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002197 conserved cys residue [active] 862719002198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002200 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 862719002201 active site 862719002202 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 862719002203 nucleotide binding site [chemical binding]; other site 862719002204 substrate binding site [chemical binding]; other site 862719002205 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 862719002206 Flavoprotein; Region: Flavoprotein; cl08021 862719002207 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862719002208 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 862719002209 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 862719002210 Flavin Reductases; Region: FlaRed; cl00801 862719002211 Protein of unknown function (DUF556); Region: DUF556; cl00822 862719002212 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862719002213 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862719002214 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 862719002215 PAS domain; Region: PAS_9; pfam13426 862719002216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719002217 putative active site [active] 862719002218 heme pocket [chemical binding]; other site 862719002219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719002220 Histidine kinase; Region: HisKA_2; cl06527 862719002221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002222 ATP binding site [chemical binding]; other site 862719002223 Mg2+ binding site [ion binding]; other site 862719002224 G-X-G motif; other site 862719002225 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 862719002226 uracil-xanthine permease; Region: ncs2; TIGR00801 862719002227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 862719002228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002229 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719002230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719002231 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 862719002232 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 862719002233 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719002234 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 862719002235 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719002236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002237 EamA-like transporter family; Region: EamA; cl01037 862719002238 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719002239 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 862719002240 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 862719002241 metal binding site [ion binding]; metal-binding site 862719002242 putative dimer interface [polypeptide binding]; other site 862719002243 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862719002244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002245 Cupin domain; Region: Cupin_2; cl09118 862719002246 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862719002247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002248 NAD(P) binding site [chemical binding]; other site 862719002249 catalytic residues [active] 862719002250 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 862719002251 tartrate dehydrogenase; Provisional; Region: PRK08194 862719002252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002253 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 862719002254 tetramerization interface [polypeptide binding]; other site 862719002255 NAD(P) binding site [chemical binding]; other site 862719002256 catalytic residues [active] 862719002257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002258 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719002259 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 862719002260 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719002261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719002262 Coenzyme A binding pocket [chemical binding]; other site 862719002263 hypothetical protein; Provisional; Region: PRK05965 862719002264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719002265 inhibitor-cofactor binding pocket; inhibition site 862719002266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719002267 catalytic residue [active] 862719002268 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 862719002269 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719002270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719002271 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 862719002272 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719002273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002274 conserved gate region; other site 862719002275 dimer interface [polypeptide binding]; other site 862719002276 putative PBP binding loops; other site 862719002277 ABC-ATPase subunit interface; other site 862719002278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719002279 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862719002280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002281 dimer interface [polypeptide binding]; other site 862719002282 conserved gate region; other site 862719002283 ABC-ATPase subunit interface; other site 862719002284 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862719002285 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719002286 Walker A/P-loop; other site 862719002287 ATP binding site [chemical binding]; other site 862719002288 Q-loop/lid; other site 862719002289 ABC transporter signature motif; other site 862719002290 Walker B; other site 862719002291 D-loop; other site 862719002292 H-loop/switch region; other site 862719002293 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719002294 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719002295 Walker A/P-loop; other site 862719002296 ATP binding site [chemical binding]; other site 862719002297 Q-loop/lid; other site 862719002298 ABC transporter signature motif; other site 862719002299 Walker B; other site 862719002300 D-loop; other site 862719002301 H-loop/switch region; other site 862719002302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719002303 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719002304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719002305 putative DNA binding site [nucleotide binding]; other site 862719002306 putative Zn2+ binding site [ion binding]; other site 862719002307 Helix-turn-helix domains; Region: HTH; cl00088 862719002308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002309 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002310 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 862719002311 Helix-turn-helix domains; Region: HTH; cl00088 862719002312 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 862719002313 putative dimerization interface [polypeptide binding]; other site 862719002314 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 862719002315 PAS domain S-box; Region: sensory_box; TIGR00229 862719002316 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719002317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719002318 dimer interface [polypeptide binding]; other site 862719002319 phosphorylation site [posttranslational modification] 862719002320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002321 ATP binding site [chemical binding]; other site 862719002322 Mg2+ binding site [ion binding]; other site 862719002323 G-X-G motif; other site 862719002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002325 active site 862719002326 phosphorylation site [posttranslational modification] 862719002327 intermolecular recognition site; other site 862719002328 dimerization interface [polypeptide binding]; other site 862719002329 Protein of unknown function (DUF808); Region: DUF808; cl01002 862719002330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719002331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002332 active site 862719002333 phosphorylation site [posttranslational modification] 862719002334 intermolecular recognition site; other site 862719002335 dimerization interface [polypeptide binding]; other site 862719002336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719002337 DNA binding residues [nucleotide binding] 862719002338 dimerization interface [polypeptide binding]; other site 862719002339 Histidine kinase; Region: HisKA_3; pfam07730 862719002340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719002341 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719002342 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 862719002343 Trp docking motif [polypeptide binding]; other site 862719002344 dimer interface [polypeptide binding]; other site 862719002345 active site 862719002346 small subunit binding site [polypeptide binding]; other site 862719002347 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 862719002348 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 862719002349 substrate binding pocket [chemical binding]; other site 862719002350 membrane-bound complex binding site; other site 862719002351 hinge residues; other site 862719002352 Cytochrome c; Region: Cytochrom_C; cl11414 862719002353 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 862719002354 MoxR-like ATPases [General function prediction only]; Region: COG0714 862719002355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719002356 Walker A motif; other site 862719002357 ATP binding site [chemical binding]; other site 862719002358 Walker B motif; other site 862719002359 arginine finger; other site 862719002360 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719002361 metal ion-dependent adhesion site (MIDAS); other site 862719002362 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862719002363 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 862719002364 putative hydrophobic ligand binding site [chemical binding]; other site 862719002365 protein interface [polypeptide binding]; other site 862719002366 gate; other site 862719002367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002368 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 862719002369 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 862719002370 homotrimer interaction site [polypeptide binding]; other site 862719002371 putative active site [active] 862719002372 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719002373 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 862719002374 transcriptional regulator EutR; Provisional; Region: PRK10130 862719002375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002376 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719002377 Amidase; Region: Amidase; cl11426 862719002378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002379 putative substrate translocation pore; other site 862719002380 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 862719002381 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 862719002382 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719002383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002384 Amino acid permease; Region: AA_permease; pfam00324 862719002385 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 862719002386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719002387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002388 hypothetical protein; Provisional; Region: PRK13560 862719002389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719002390 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719002391 dimer interface [polypeptide binding]; other site 862719002392 putative CheW interface [polypeptide binding]; other site 862719002393 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862719002394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002395 NAD(P) binding site [chemical binding]; other site 862719002396 catalytic residues [active] 862719002397 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 862719002398 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 862719002399 dimer interface [polypeptide binding]; other site 862719002400 active site 862719002401 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 862719002402 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 862719002403 active site 862719002404 dimer interface [polypeptide binding]; other site 862719002405 metal binding site [ion binding]; metal-binding site 862719002406 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 862719002407 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719002408 Helix-turn-helix domains; Region: HTH; cl00088 862719002409 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719002410 putative effector binding pocket; other site 862719002411 dimerization interface [polypeptide binding]; other site 862719002412 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 862719002413 Amidase; Region: Amidase; cl11426 862719002414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719002415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719002416 active site 862719002417 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719002418 [2Fe-2S] cluster binding site [ion binding]; other site 862719002419 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 862719002420 putative alpha subunit interface [polypeptide binding]; other site 862719002421 putative active site [active] 862719002422 putative substrate binding site [chemical binding]; other site 862719002423 Fe binding site [ion binding]; other site 862719002424 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 862719002425 inter-subunit interface; other site 862719002426 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 862719002427 classical (c) SDRs; Region: SDR_c; cd05233 862719002428 NAD(P) binding site [chemical binding]; other site 862719002429 active site 862719002430 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 862719002431 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 862719002432 FMN-binding pocket [chemical binding]; other site 862719002433 flavin binding motif; other site 862719002434 phosphate binding motif [ion binding]; other site 862719002435 beta-alpha-beta structure motif; other site 862719002436 NAD binding pocket [chemical binding]; other site 862719002437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719002438 catalytic loop [active] 862719002439 iron binding site [ion binding]; other site 862719002440 Flavin Reductases; Region: FlaRed; cl00801 862719002441 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719002442 Helix-turn-helix domains; Region: HTH; cl00088 862719002443 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 862719002444 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719002445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719002446 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719002447 Walker A/P-loop; other site 862719002448 ATP binding site [chemical binding]; other site 862719002449 Q-loop/lid; other site 862719002450 ABC transporter signature motif; other site 862719002451 Walker B; other site 862719002452 D-loop; other site 862719002453 H-loop/switch region; other site 862719002454 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719002455 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719002456 Walker A/P-loop; other site 862719002457 ATP binding site [chemical binding]; other site 862719002458 Q-loop/lid; other site 862719002459 ABC transporter signature motif; other site 862719002460 Walker B; other site 862719002461 D-loop; other site 862719002462 H-loop/switch region; other site 862719002463 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719002464 TM-ABC transporter signature motif; other site 862719002465 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719002466 TM-ABC transporter signature motif; other site 862719002467 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 862719002468 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719002469 putative ligand binding site [chemical binding]; other site 862719002470 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719002471 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 862719002472 metal binding site [ion binding]; metal-binding site 862719002473 substrate binding pocket [chemical binding]; other site 862719002474 Muconolactone delta-isomerase; Region: MIase; cl01992 862719002475 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 862719002476 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 862719002477 dimer interface [polypeptide binding]; other site 862719002478 active site 862719002479 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 862719002480 Helix-turn-helix domains; Region: HTH; cl00088 862719002481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002482 dimerization interface [polypeptide binding]; other site 862719002483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719002484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 862719002485 ligand binding site [chemical binding]; other site 862719002486 flexible hinge region; other site 862719002487 Helix-turn-helix domains; Region: HTH; cl00088 862719002488 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 862719002489 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 862719002490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002492 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719002493 DNA binding residues [nucleotide binding] 862719002494 dimerization interface [polypeptide binding]; other site 862719002495 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719002496 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002497 Evidence 5 : No homology to any previously reported sequences 862719002498 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862719002499 iron-sulfur cluster [ion binding]; other site 862719002500 [2Fe-2S] cluster binding site [ion binding]; other site 862719002501 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 862719002502 putative alpha subunit interface [polypeptide binding]; other site 862719002503 putative active site [active] 862719002504 putative substrate binding site [chemical binding]; other site 862719002505 Fe binding site [ion binding]; other site 862719002506 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 862719002507 inter-subunit interface; other site 862719002508 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 862719002509 [2Fe-2S] cluster binding site [ion binding]; other site 862719002510 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 862719002511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002512 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719002513 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 862719002514 putative ligand binding site [chemical binding]; other site 862719002515 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719002516 TM-ABC transporter signature motif; other site 862719002517 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719002518 TM-ABC transporter signature motif; other site 862719002519 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719002520 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719002521 Walker A/P-loop; other site 862719002522 ATP binding site [chemical binding]; other site 862719002523 Q-loop/lid; other site 862719002524 ABC transporter signature motif; other site 862719002525 Walker B; other site 862719002526 D-loop; other site 862719002527 H-loop/switch region; other site 862719002528 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719002529 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719002530 Walker A/P-loop; other site 862719002531 ATP binding site [chemical binding]; other site 862719002532 Q-loop/lid; other site 862719002533 ABC transporter signature motif; other site 862719002534 Walker B; other site 862719002535 D-loop; other site 862719002536 H-loop/switch region; other site 862719002537 multicopper oxidase; Provisional; Region: PRK10965 862719002538 Integrase core domain; Region: rve; cl01316 862719002539 transposase; Validated; Region: PRK08181 862719002540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002541 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 862719002542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719002543 substrate binding pocket [chemical binding]; other site 862719002544 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719002545 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 862719002546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002547 putative substrate translocation pore; other site 862719002548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719002549 Carboxylesterase family; Region: COesterase; pfam00135 862719002550 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719002551 substrate binding pocket [chemical binding]; other site 862719002552 catalytic triad [active] 862719002553 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719002554 Helix-turn-helix domains; Region: HTH; cl00088 862719002555 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719002556 putative effector binding pocket; other site 862719002557 dimerization interface [polypeptide binding]; other site 862719002558 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002559 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2159625; Product type e : enzyme 862719002560 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002561 FOG: CBS domain [General function prediction only]; Region: COG0517 862719002562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 862719002563 FOG: CBS domain [General function prediction only]; Region: COG0517 862719002564 BON domain; Region: BON; cl02771 862719002565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002566 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719002567 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719002568 Helix-turn-helix domains; Region: HTH; cl00088 862719002569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002570 dimerization interface [polypeptide binding]; other site 862719002571 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 862719002572 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 862719002573 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719002574 GAF domain; Region: GAF; cl15785 862719002575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719002576 active site 862719002577 I-site; other site 862719002578 metal binding site [ion binding]; metal-binding site 862719002579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719002580 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 862719002581 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719002582 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719002583 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719002584 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 862719002585 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719002586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719002587 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 862719002588 Int/Topo IB signature motif; other site 862719002589 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002590 transposase; Validated; Region: PRK08181 862719002591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002592 Integrase core domain; Region: rve; cl01316 862719002593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002594 non-specific DNA binding site [nucleotide binding]; other site 862719002595 salt bridge; other site 862719002596 sequence-specific DNA binding site [nucleotide binding]; other site 862719002597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002598 non-specific DNA binding site [nucleotide binding]; other site 862719002599 salt bridge; other site 862719002600 sequence-specific DNA binding site [nucleotide binding]; other site 862719002601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719002602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002603 non-specific DNA binding site [nucleotide binding]; other site 862719002604 salt bridge; other site 862719002605 sequence-specific DNA binding site [nucleotide binding]; other site 862719002606 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 862719002607 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719002608 Replication initiator protein A; Region: RPA; cl02339 862719002609 ParA-like protein; Provisional; Region: PHA02518 862719002610 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719002611 P-loop; other site 862719002612 Magnesium ion binding site [ion binding]; other site 862719002613 ParA-like protein; Provisional; Region: PHA02518 862719002614 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719002615 P-loop; other site 862719002616 Magnesium ion binding site [ion binding]; other site 862719002617 Evidence 7 : Gene remnant; Product type f : factor 862719002618 Evidence 7 : Gene remnant; PubMedId : 1665997; Product type f : factor 862719002619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002620 Walker A motif; other site 862719002621 ATP binding site [chemical binding]; other site 862719002622 Walker B motif; other site 862719002623 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 862719002624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002625 Walker B; other site 862719002626 D-loop; other site 862719002627 H-loop/switch region; other site 862719002628 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 862719002629 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719002630 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719002631 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719002632 VirB7 interaction site; other site 862719002633 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 862719002634 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 862719002635 Helix-turn-helix domains; Region: HTH; cl00088 862719002636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719002637 dimerization interface [polypeptide binding]; other site 862719002638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719002639 binding surface 862719002640 TPR motif; other site 862719002641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 862719002642 CHAT domain; Region: CHAT; pfam12770 862719002643 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 862719002644 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 862719002645 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 862719002646 putative active site [active] 862719002647 putative NTP binding site [chemical binding]; other site 862719002648 putative nucleic acid binding site [nucleotide binding]; other site 862719002649 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 862719002650 CRISPR-associated protein; Region: TIGR03986 862719002651 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 862719002652 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 862719002653 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 862719002654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002655 Walker A/P-loop; other site 862719002656 ATP binding site [chemical binding]; other site 862719002657 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862719002658 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 862719002659 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 862719002660 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 862719002661 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 862719002662 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 862719002663 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 862719002664 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 862719002665 Helix-turn-helix domains; Region: HTH; cl00088 862719002666 Helix-turn-helix domains; Region: HTH; cl00088 862719002667 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002668 Evidence 7 : Gene remnant; Product type e : enzyme 862719002669 Evidence 7 : Gene remnant; Product type e : enzyme 862719002670 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002671 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 862719002672 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 862719002673 Integrase core domain; Region: rve; cl01316 862719002674 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719002675 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 862719002676 Helix-turn-helix domains; Region: HTH; cl00088 862719002677 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002678 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002679 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002680 Helix-turn-helix domains; Region: HTH; cl00088 862719002681 Helix-turn-helix domains; Region: HTH; cl00088 862719002682 Evidence 7 : Gene remnant; Product type e : enzyme 862719002683 Evidence 7 : Gene remnant; Product type e : enzyme 862719002684 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719002685 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002686 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002687 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 862719002688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719002689 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002690 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002691 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002692 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719002693 Helix-turn-helix domains; Region: HTH; cl00088 862719002694 Helix-turn-helix domains; Region: HTH; cl00088 862719002695 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002696 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719002697 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 862719002698 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 862719002699 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002700 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719002701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002702 Walker A/P-loop; other site 862719002703 ATP binding site [chemical binding]; other site 862719002704 Q-loop/lid; other site 862719002705 ABC transporter signature motif; other site 862719002706 Walker B; other site 862719002707 D-loop; other site 862719002708 H-loop/switch region; other site 862719002709 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719002710 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 862719002711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002712 Walker A/P-loop; other site 862719002713 ATP binding site [chemical binding]; other site 862719002714 Q-loop/lid; other site 862719002715 ABC transporter signature motif; other site 862719002716 Walker B; other site 862719002717 D-loop; other site 862719002718 H-loop/switch region; other site 862719002719 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719002720 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719002721 Walker A/P-loop; other site 862719002722 ATP binding site [chemical binding]; other site 862719002723 Q-loop/lid; other site 862719002724 ABC transporter signature motif; other site 862719002725 Walker B; other site 862719002726 D-loop; other site 862719002727 H-loop/switch region; other site 862719002728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719002729 dimer interface [polypeptide binding]; other site 862719002730 putative PBP binding regions; other site 862719002731 ABC-ATPase subunit interface; other site 862719002732 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 862719002733 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719002734 intersubunit interface [polypeptide binding]; other site 862719002735 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719002736 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719002737 N-terminal plug; other site 862719002738 ligand-binding site [chemical binding]; other site 862719002739 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719002740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002741 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 862719002742 AMP-binding enzyme; Region: AMP-binding; cl15778 862719002743 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719002744 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002745 Condensation domain; Region: Condensation; pfam00668 862719002746 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 862719002747 Nonribosomal peptide synthase; Region: NRPS; pfam08415 862719002748 AMP-binding enzyme; Region: AMP-binding; cl15778 862719002749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719002750 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002751 Condensation domain; Region: Condensation; pfam00668 862719002752 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 862719002753 Nonribosomal peptide synthase; Region: NRPS; pfam08415 862719002754 AMP-binding enzyme; Region: AMP-binding; cl15778 862719002755 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719002756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719002757 S-adenosylmethionine binding site [chemical binding]; other site 862719002758 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 862719002759 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002760 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 862719002761 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 862719002762 Chorismate mutase type II; Region: CM_2; cl00693 862719002763 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 862719002764 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719002765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002766 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 862719002767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002768 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 862719002769 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 862719002770 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 862719002771 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719002772 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719002773 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719002774 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 862719002775 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002776 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719002777 DctM-like transporters; Region: DctM; pfam06808 862719002778 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719002779 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 862719002780 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 862719002781 inhibitor site; inhibition site 862719002782 active site 862719002783 dimer interface [polypeptide binding]; other site 862719002784 catalytic residue [active] 862719002785 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862719002786 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 862719002787 substrate binding site [chemical binding]; other site 862719002788 ATP binding site [chemical binding]; other site 862719002789 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719002790 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719002791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719002792 DNA binding site [nucleotide binding] 862719002793 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 862719002794 domain linker motif; other site 862719002795 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 862719002796 putative dimerization interface [polypeptide binding]; other site 862719002797 putative ligand binding site [chemical binding]; other site 862719002798 Transposase domain (DUF772); Region: DUF772; cl15789 862719002799 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002800 Cupin domain; Region: Cupin_2; cl09118 862719002801 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719002802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002803 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 862719002804 Fusaric acid resistance protein family; Region: FUSC; pfam04632 862719002805 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 862719002806 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719002807 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719002808 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002809 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719002810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002811 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719002812 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719002813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719002814 DNA-binding site [nucleotide binding]; DNA binding site 862719002815 UTRA domain; Region: UTRA; cl01230 862719002816 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 862719002817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719002818 active site 862719002819 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 862719002820 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 862719002821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002822 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 862719002823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002824 Walker A/P-loop; other site 862719002825 ATP binding site [chemical binding]; other site 862719002826 Q-loop/lid; other site 862719002827 ABC transporter signature motif; other site 862719002828 Walker B; other site 862719002829 D-loop; other site 862719002830 H-loop/switch region; other site 862719002831 TOBE domain; Region: TOBE_2; cl01440 862719002832 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 862719002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719002834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002835 dimer interface [polypeptide binding]; other site 862719002836 conserved gate region; other site 862719002837 putative PBP binding loops; other site 862719002838 ABC-ATPase subunit interface; other site 862719002839 Helix-turn-helix domains; Region: HTH; cl00088 862719002840 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 862719002841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719002842 dimerization interface [polypeptide binding]; other site 862719002843 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 862719002844 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719002845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719002846 catalytic residue [active] 862719002847 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 862719002848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719002849 motif II; other site 862719002850 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 862719002851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719002852 inhibitor-cofactor binding pocket; inhibition site 862719002853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719002854 catalytic residue [active] 862719002855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719002856 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719002857 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719002858 dimer interface [polypeptide binding]; other site 862719002859 putative CheW interface [polypeptide binding]; other site 862719002860 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719002861 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719002862 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 862719002863 ligand binding site [chemical binding]; other site 862719002864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719002865 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719002866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002867 ATP binding site [chemical binding]; other site 862719002868 Mg2+ binding site [ion binding]; other site 862719002869 G-X-G motif; other site 862719002870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719002872 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719002873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719002874 metal binding site [ion binding]; metal-binding site 862719002875 active site 862719002876 I-site; other site 862719002877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719002878 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719002879 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 862719002880 Transposase [DNA replication, recombination, and repair]; Region: COG5433 862719002881 Transposase [DNA replication, recombination, and repair]; Region: COG5433 862719002882 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 862719002883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002884 AMP-binding enzyme; Region: AMP-binding; cl15778 862719002885 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 862719002886 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 862719002887 putative catalytic cysteine [active] 862719002888 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719002889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719002890 Walker A/P-loop; other site 862719002891 ATP binding site [chemical binding]; other site 862719002892 Q-loop/lid; other site 862719002893 ABC transporter signature motif; other site 862719002894 Walker B; other site 862719002895 D-loop; other site 862719002896 H-loop/switch region; other site 862719002897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719002898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 862719002899 NMT1/THI5 like; Region: NMT1; pfam09084 862719002900 substrate binding pocket [chemical binding]; other site 862719002901 membrane-bound complex binding site; other site 862719002902 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 862719002903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002904 NAD(P) binding site [chemical binding]; other site 862719002905 active site 862719002906 phosphoglycolate phosphatase; Provisional; Region: PRK13222 862719002907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719002908 motif II; other site 862719002909 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 862719002910 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 862719002911 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 862719002912 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 862719002913 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 862719002914 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 862719002915 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719002916 Histidine kinase; Region: His_kinase; pfam06580 862719002917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002918 ATP binding site [chemical binding]; other site 862719002919 Mg2+ binding site [ion binding]; other site 862719002920 G-X-G motif; other site 862719002921 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 862719002922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002923 active site 862719002924 phosphorylation site [posttranslational modification] 862719002925 intermolecular recognition site; other site 862719002926 dimerization interface [polypeptide binding]; other site 862719002927 LytTr DNA-binding domain; Region: LytTR; cl04498 862719002928 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 862719002929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719002931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002932 ATP binding site [chemical binding]; other site 862719002933 Mg2+ binding site [ion binding]; other site 862719002934 G-X-G motif; other site 862719002935 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 862719002936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002937 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 862719002938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002939 active site 862719002940 phosphorylation site [posttranslational modification] 862719002941 intermolecular recognition site; other site 862719002942 dimerization interface [polypeptide binding]; other site 862719002943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719002944 DNA binding site [nucleotide binding] 862719002945 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719002946 Integral membrane protein TerC family; Region: TerC; cl10468 862719002947 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 862719002948 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 862719002949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719002950 NMT1-like family; Region: NMT1_2; cl15260 862719002951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719002952 NMT1-like family; Region: NMT1_2; cl15260 862719002953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719002954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002955 active site 862719002956 phosphorylation site [posttranslational modification] 862719002957 intermolecular recognition site; other site 862719002958 dimerization interface [polypeptide binding]; other site 862719002959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719002960 DNA binding residues [nucleotide binding] 862719002961 dimerization interface [polypeptide binding]; other site 862719002962 Histidine kinase; Region: HisKA_3; pfam07730 862719002963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002964 ATP binding site [chemical binding]; other site 862719002965 Mg2+ binding site [ion binding]; other site 862719002966 G-X-G motif; other site 862719002967 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719002968 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 862719002969 dimer interface [polypeptide binding]; other site 862719002970 Trp docking motif [polypeptide binding]; other site 862719002971 active site 862719002972 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719002973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719002974 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719002975 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719002976 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 862719002977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719002978 kynureninase; Region: kynureninase; TIGR01814 862719002979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719002980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719002981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719002982 catalytic residue [active] 862719002983 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 862719002984 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 862719002985 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 862719002986 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 862719002987 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719002988 Helix-turn-helix domains; Region: HTH; cl00088 862719002989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002990 dimerization interface [polypeptide binding]; other site 862719002991 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719002992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719002993 NAD(P) binding site [chemical binding]; other site 862719002994 active site 862719002995 transketolase; Reviewed; Region: PRK05899 862719002996 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719002997 TPP-binding site [chemical binding]; other site 862719002998 dimer interface [polypeptide binding]; other site 862719002999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719003000 PYR/PP interface [polypeptide binding]; other site 862719003001 dimer interface [polypeptide binding]; other site 862719003002 TPP binding site [chemical binding]; other site 862719003003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719003004 glycerate dehydrogenase; Provisional; Region: PRK06932 862719003005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003006 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 862719003007 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 862719003008 MOFRL family; Region: MOFRL; pfam05161 862719003009 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719003010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003011 DNA-binding site [nucleotide binding]; DNA binding site 862719003012 FCD domain; Region: FCD; cl11656 862719003013 NMT1-like family; Region: NMT1_2; cl15260 862719003014 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719003015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003016 dimer interface [polypeptide binding]; other site 862719003017 conserved gate region; other site 862719003018 putative PBP binding loops; other site 862719003019 ABC-ATPase subunit interface; other site 862719003020 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719003021 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719003022 Walker A/P-loop; other site 862719003023 ATP binding site [chemical binding]; other site 862719003024 Q-loop/lid; other site 862719003025 ABC transporter signature motif; other site 862719003026 Walker B; other site 862719003027 D-loop; other site 862719003028 H-loop/switch region; other site 862719003029 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719003030 dihydropyrimidinase; Provisional; Region: PRK13404 862719003031 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 862719003032 tetramer interface [polypeptide binding]; other site 862719003033 active site 862719003034 mannonate dehydratase; Region: uxuA; TIGR00695 862719003035 mannonate dehydratase; Provisional; Region: PRK03906 862719003036 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 862719003037 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719003038 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719003039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003040 D-galactonate transporter; Region: 2A0114; TIGR00893 862719003041 putative substrate translocation pore; other site 862719003042 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719003043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719003044 metal binding site [ion binding]; metal-binding site 862719003045 active site 862719003046 I-site; other site 862719003047 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719003048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003049 DNA-binding site [nucleotide binding]; DNA binding site 862719003050 FCD domain; Region: FCD; cl11656 862719003051 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719003052 Amidase; Region: Amidase; cl11426 862719003053 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 862719003054 active site 862719003055 homotetramer interface [polypeptide binding]; other site 862719003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003057 dimer interface [polypeptide binding]; other site 862719003058 conserved gate region; other site 862719003059 putative PBP binding loops; other site 862719003060 ABC-ATPase subunit interface; other site 862719003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003062 dimer interface [polypeptide binding]; other site 862719003063 conserved gate region; other site 862719003064 putative PBP binding loops; other site 862719003065 ABC-ATPase subunit interface; other site 862719003066 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719003067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719003068 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719003069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003070 Walker A/P-loop; other site 862719003071 ATP binding site [chemical binding]; other site 862719003072 Q-loop/lid; other site 862719003073 ABC transporter signature motif; other site 862719003074 Walker B; other site 862719003075 D-loop; other site 862719003076 H-loop/switch region; other site 862719003077 TOBE domain; Region: TOBE_2; cl01440 862719003078 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 862719003079 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 862719003080 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 862719003081 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719003082 FliG C-terminal domain; Region: FliG_C; pfam01706 862719003083 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862719003084 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719003085 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719003086 putative active site [active] 862719003087 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 862719003088 homodimer interface [polypeptide binding]; other site 862719003089 substrate-cofactor binding pocket; other site 862719003090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003091 catalytic residue [active] 862719003092 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 862719003093 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719003094 Walker A/P-loop; other site 862719003095 ATP binding site [chemical binding]; other site 862719003096 Q-loop/lid; other site 862719003097 ABC transporter signature motif; other site 862719003098 Walker B; other site 862719003099 D-loop; other site 862719003100 H-loop/switch region; other site 862719003101 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003102 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719003103 Walker A/P-loop; other site 862719003104 ATP binding site [chemical binding]; other site 862719003105 Q-loop/lid; other site 862719003106 ABC transporter signature motif; other site 862719003107 Walker B; other site 862719003108 D-loop; other site 862719003109 H-loop/switch region; other site 862719003110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003111 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 862719003112 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 862719003113 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 862719003114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003115 dimer interface [polypeptide binding]; other site 862719003116 conserved gate region; other site 862719003117 putative PBP binding loops; other site 862719003118 ABC-ATPase subunit interface; other site 862719003119 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 862719003120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003121 dimer interface [polypeptide binding]; other site 862719003122 conserved gate region; other site 862719003123 putative PBP binding loops; other site 862719003124 ABC-ATPase subunit interface; other site 862719003125 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 862719003126 homodimer interface [polypeptide binding]; other site 862719003127 homotetramer interface [polypeptide binding]; other site 862719003128 active site pocket [active] 862719003129 cleavage site 862719003130 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 862719003131 SxDxEG motif; other site 862719003132 active site 862719003133 metal binding site [ion binding]; metal-binding site 862719003134 homopentamer interface [polypeptide binding]; other site 862719003135 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 862719003136 catalytic nucleophile [active] 862719003137 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 862719003138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 862719003139 putative NAD(P) binding site [chemical binding]; other site 862719003140 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 862719003141 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 862719003142 dimer interface [polypeptide binding]; other site 862719003143 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862719003144 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719003145 Walker A/P-loop; other site 862719003146 ATP binding site [chemical binding]; other site 862719003147 Q-loop/lid; other site 862719003148 ABC transporter signature motif; other site 862719003149 Walker B; other site 862719003150 D-loop; other site 862719003151 H-loop/switch region; other site 862719003152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003153 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719003154 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719003155 Walker A/P-loop; other site 862719003156 ATP binding site [chemical binding]; other site 862719003157 Q-loop/lid; other site 862719003158 ABC transporter signature motif; other site 862719003159 Walker B; other site 862719003160 D-loop; other site 862719003161 H-loop/switch region; other site 862719003162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003163 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 862719003164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 862719003165 dimer interface [polypeptide binding]; other site 862719003166 active site 862719003167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719003168 substrate binding site [chemical binding]; other site 862719003169 catalytic residue [active] 862719003170 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 862719003171 homotrimer interaction site [polypeptide binding]; other site 862719003172 putative active site [active] 862719003173 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 862719003174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719003175 active site 862719003176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719003177 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719003178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003179 dimer interface [polypeptide binding]; other site 862719003180 conserved gate region; other site 862719003181 putative PBP binding loops; other site 862719003182 ABC-ATPase subunit interface; other site 862719003183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719003184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003185 dimer interface [polypeptide binding]; other site 862719003186 conserved gate region; other site 862719003187 putative PBP binding loops; other site 862719003188 ABC-ATPase subunit interface; other site 862719003189 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719003190 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 862719003191 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719003192 Helix-turn-helix domains; Region: HTH; cl00088 862719003193 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719003194 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 862719003195 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719003196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003197 active site 862719003198 phosphorylation site [posttranslational modification] 862719003199 intermolecular recognition site; other site 862719003200 dimerization interface [polypeptide binding]; other site 862719003201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719003202 DNA binding residues [nucleotide binding] 862719003203 dimerization interface [polypeptide binding]; other site 862719003204 MASE1; Region: MASE1; pfam05231 862719003205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003206 dimer interface [polypeptide binding]; other site 862719003207 phosphorylation site [posttranslational modification] 862719003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003209 ATP binding site [chemical binding]; other site 862719003210 Mg2+ binding site [ion binding]; other site 862719003211 G-X-G motif; other site 862719003212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719003213 Ligand Binding Site [chemical binding]; other site 862719003214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719003215 Ligand Binding Site [chemical binding]; other site 862719003216 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719003217 active site 862719003218 phosphorylation site [posttranslational modification] 862719003219 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 862719003220 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862719003221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719003222 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 862719003223 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 862719003224 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 862719003225 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 862719003226 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719003227 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 862719003228 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 862719003229 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 862719003230 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 862719003231 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 862719003232 P-loop; other site 862719003233 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 862719003234 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 862719003235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003236 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 862719003237 FHIPEP family; Region: FHIPEP; pfam00771 862719003238 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719003239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719003240 Walker A motif; other site 862719003241 ATP binding site [chemical binding]; other site 862719003242 Walker B motif; other site 862719003243 arginine finger; other site 862719003244 Helix-turn-helix domains; Region: HTH; cl00088 862719003245 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719003246 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719003247 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 862719003248 Flagellar assembly protein FliH; Region: FliH; pfam02108 862719003249 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 862719003250 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 862719003251 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 862719003252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719003253 non-specific DNA binding site [nucleotide binding]; other site 862719003254 salt bridge; other site 862719003255 sequence-specific DNA binding site [nucleotide binding]; other site 862719003256 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719003257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719003258 putative active site [active] 862719003259 heme pocket [chemical binding]; other site 862719003260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003261 dimer interface [polypeptide binding]; other site 862719003262 phosphorylation site [posttranslational modification] 862719003263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003264 ATP binding site [chemical binding]; other site 862719003265 Mg2+ binding site [ion binding]; other site 862719003266 G-X-G motif; other site 862719003267 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003269 active site 862719003270 phosphorylation site [posttranslational modification] 862719003271 intermolecular recognition site; other site 862719003272 dimerization interface [polypeptide binding]; other site 862719003273 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719003274 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003276 active site 862719003277 phosphorylation site [posttranslational modification] 862719003278 intermolecular recognition site; other site 862719003279 dimerization interface [polypeptide binding]; other site 862719003280 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 862719003281 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 862719003282 Domain of unknown function DUF21; Region: DUF21; pfam01595 862719003283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862719003284 Transporter associated domain; Region: CorC_HlyC; cl08393 862719003285 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719003286 Sodium:solute symporter family; Region: SSF; cl00456 862719003287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003289 dimer interface [polypeptide binding]; other site 862719003290 phosphorylation site [posttranslational modification] 862719003291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003292 ATP binding site [chemical binding]; other site 862719003293 Mg2+ binding site [ion binding]; other site 862719003294 G-X-G motif; other site 862719003295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003296 active site 862719003297 phosphorylation site [posttranslational modification] 862719003298 intermolecular recognition site; other site 862719003299 dimerization interface [polypeptide binding]; other site 862719003300 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003302 active site 862719003303 phosphorylation site [posttranslational modification] 862719003304 intermolecular recognition site; other site 862719003305 dimerization interface [polypeptide binding]; other site 862719003306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719003307 DNA binding residues [nucleotide binding] 862719003308 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 862719003309 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719003310 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719003311 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003312 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 862719003313 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 862719003314 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719003315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719003316 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719003317 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 862719003318 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 862719003319 thiamine pyrophosphate protein; Provisional; Region: PRK08273 862719003320 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 862719003321 PYR/PP interface [polypeptide binding]; other site 862719003322 dimer interface [polypeptide binding]; other site 862719003323 tetramer interface [polypeptide binding]; other site 862719003324 TPP binding site [chemical binding]; other site 862719003325 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 862719003326 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 862719003327 TPP-binding site [chemical binding]; other site 862719003328 Sensors of blue-light using FAD; Region: BLUF; cl04855 862719003329 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719003330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719003331 ligand binding site [chemical binding]; other site 862719003332 flexible hinge region; other site 862719003333 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 862719003334 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719003335 active site 862719003336 dimer interface [polypeptide binding]; other site 862719003337 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719003338 Ligand Binding Site [chemical binding]; other site 862719003339 Molecular Tunnel; other site 862719003340 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 862719003341 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719003342 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719003343 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719003344 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 862719003345 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 862719003346 putative oligomer interface [polypeptide binding]; other site 862719003347 putative active site [active] 862719003348 metal binding site [ion binding]; metal-binding site 862719003349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003350 dimer interface [polypeptide binding]; other site 862719003351 phosphorylation site [posttranslational modification] 862719003352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003353 ATP binding site [chemical binding]; other site 862719003354 Mg2+ binding site [ion binding]; other site 862719003355 G-X-G motif; other site 862719003356 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003358 active site 862719003359 phosphorylation site [posttranslational modification] 862719003360 intermolecular recognition site; other site 862719003361 dimerization interface [polypeptide binding]; other site 862719003362 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003364 active site 862719003365 phosphorylation site [posttranslational modification] 862719003366 intermolecular recognition site; other site 862719003367 dimerization interface [polypeptide binding]; other site 862719003368 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719003369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003370 active site 862719003371 phosphorylation site [posttranslational modification] 862719003372 intermolecular recognition site; other site 862719003373 dimerization interface [polypeptide binding]; other site 862719003374 CheB methylesterase; Region: CheB_methylest; pfam01339 862719003375 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719003376 putative binding surface; other site 862719003377 active site 862719003378 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 862719003379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003380 ATP binding site [chemical binding]; other site 862719003381 Mg2+ binding site [ion binding]; other site 862719003382 G-X-G motif; other site 862719003383 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003385 active site 862719003386 phosphorylation site [posttranslational modification] 862719003387 intermolecular recognition site; other site 862719003388 dimerization interface [polypeptide binding]; other site 862719003389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003390 dimerization interface [polypeptide binding]; other site 862719003391 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003393 dimer interface [polypeptide binding]; other site 862719003394 putative CheW interface [polypeptide binding]; other site 862719003395 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 862719003396 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862719003397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719003399 TPR motif; other site 862719003400 binding surface 862719003401 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719003402 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 862719003403 putative active site [active] 862719003404 putative catalytic site [active] 862719003405 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 862719003406 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719003407 active site 862719003408 metal binding site [ion binding]; metal-binding site 862719003409 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 862719003410 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 862719003411 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 862719003412 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719003413 phosphate binding site [ion binding]; other site 862719003414 Nitrate and nitrite sensing; Region: NIT; pfam08376 862719003415 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 862719003416 ANTAR domain; Region: ANTAR; cl04297 862719003417 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 862719003418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719003419 Helix-turn-helix domains; Region: HTH; cl00088 862719003420 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862719003421 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862719003422 NAD binding site [chemical binding]; other site 862719003423 homodimer interface [polypeptide binding]; other site 862719003424 active site 862719003425 substrate binding site [chemical binding]; other site 862719003426 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719003427 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 862719003428 Walker A/P-loop; other site 862719003429 ATP binding site [chemical binding]; other site 862719003430 Q-loop/lid; other site 862719003431 ABC transporter signature motif; other site 862719003432 Walker B; other site 862719003433 D-loop; other site 862719003434 H-loop/switch region; other site 862719003435 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719003436 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719003437 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719003438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719003439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719003440 S-adenosylmethionine binding site [chemical binding]; other site 862719003441 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 862719003442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719003443 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 862719003444 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 862719003445 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 862719003446 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 862719003447 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 862719003448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719003449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719003450 ATP binding site [chemical binding]; other site 862719003451 putative Mg++ binding site [ion binding]; other site 862719003452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719003453 nucleotide binding region [chemical binding]; other site 862719003454 ATP-binding site [chemical binding]; other site 862719003455 TRCF domain; Region: TRCF; cl04088 862719003456 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 862719003457 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 862719003458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719003459 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 862719003460 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862719003461 DNA binding site [nucleotide binding] 862719003462 active site 862719003463 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719003464 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719003465 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 862719003466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003467 Walker A/P-loop; other site 862719003468 ATP binding site [chemical binding]; other site 862719003469 Q-loop/lid; other site 862719003470 ABC transporter signature motif; other site 862719003471 Walker B; other site 862719003472 D-loop; other site 862719003473 H-loop/switch region; other site 862719003474 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 862719003475 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003476 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003477 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003478 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003479 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719003480 ligand binding site [chemical binding]; other site 862719003481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719003482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719003483 substrate binding pocket [chemical binding]; other site 862719003484 membrane-bound complex binding site; other site 862719003485 hinge residues; other site 862719003486 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 862719003487 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 862719003488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719003489 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719003490 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 862719003491 dimer interface [polypeptide binding]; other site 862719003492 Trp docking motif [polypeptide binding]; other site 862719003493 active site 862719003494 Cytochrome c; Region: Cytochrom_C; cl11414 862719003495 Cache domain; Region: Cache_2; cl07034 862719003496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 862719003497 NMT1-like family; Region: NMT1_2; cl15260 862719003498 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719003499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003500 dimer interface [polypeptide binding]; other site 862719003501 conserved gate region; other site 862719003502 putative PBP binding loops; other site 862719003503 ABC-ATPase subunit interface; other site 862719003504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003505 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 862719003506 Walker A/P-loop; other site 862719003507 ATP binding site [chemical binding]; other site 862719003508 Q-loop/lid; other site 862719003509 ABC transporter signature motif; other site 862719003510 Walker B; other site 862719003511 D-loop; other site 862719003512 H-loop/switch region; other site 862719003513 Protein of unknown function (DUF461); Region: DUF461; cl01071 862719003514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719003515 putative active site [active] 862719003516 heme pocket [chemical binding]; other site 862719003517 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003519 active site 862719003520 phosphorylation site [posttranslational modification] 862719003521 intermolecular recognition site; other site 862719003522 dimerization interface [polypeptide binding]; other site 862719003523 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003525 active site 862719003526 phosphorylation site [posttranslational modification] 862719003527 intermolecular recognition site; other site 862719003528 dimerization interface [polypeptide binding]; other site 862719003529 PAS domain S-box; Region: sensory_box; TIGR00229 862719003530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719003531 putative active site [active] 862719003532 heme pocket [chemical binding]; other site 862719003533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719003534 Histidine kinase; Region: HisKA_2; cl06527 862719003535 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003537 active site 862719003538 phosphorylation site [posttranslational modification] 862719003539 intermolecular recognition site; other site 862719003540 dimerization interface [polypeptide binding]; other site 862719003541 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 862719003542 GAF domain; Region: GAF; cl15785 862719003543 Phytochrome region; Region: PHY; pfam00360 862719003544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003545 dimer interface [polypeptide binding]; other site 862719003546 phosphorylation site [posttranslational modification] 862719003547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003548 ATP binding site [chemical binding]; other site 862719003549 Mg2+ binding site [ion binding]; other site 862719003550 G-X-G motif; other site 862719003551 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 862719003552 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719003553 FMN binding site [chemical binding]; other site 862719003554 substrate binding site [chemical binding]; other site 862719003555 putative catalytic residue [active] 862719003556 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719003557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003558 DNA-binding site [nucleotide binding]; DNA binding site 862719003559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719003560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003561 homodimer interface [polypeptide binding]; other site 862719003562 catalytic residue [active] 862719003563 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719003564 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003565 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719003566 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003567 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003568 Cytochrome c; Region: Cytochrom_C; cl11414 862719003569 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719003570 Cytochrome c; Region: Cytochrom_C; cl11414 862719003571 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719003572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719003573 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719003574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719003575 Helix-turn-helix domains; Region: HTH; cl00088 862719003576 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 862719003577 hypothetical protein; Provisional; Region: PRK06847 862719003578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003579 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719003580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719003581 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719003582 Isochorismatase family; Region: Isochorismatase; pfam00857 862719003583 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 862719003584 catalytic triad [active] 862719003585 substrate binding site [chemical binding]; other site 862719003586 domain interfaces; other site 862719003587 conserved cis-peptide bond; other site 862719003588 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 862719003589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003590 putative substrate translocation pore; other site 862719003591 Cache domain; Region: Cache_2; cl07034 862719003592 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719003593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003594 dimerization interface [polypeptide binding]; other site 862719003595 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003597 dimer interface [polypeptide binding]; other site 862719003598 putative CheW interface [polypeptide binding]; other site 862719003599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719003600 Helix-turn-helix domains; Region: HTH; cl00088 862719003601 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719003602 putative effector binding pocket; other site 862719003603 dimerization interface [polypeptide binding]; other site 862719003604 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719003605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003606 AMP-binding enzyme; Region: AMP-binding; cl15778 862719003607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719003608 Helix-turn-helix domains; Region: HTH; cl00088 862719003609 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 862719003610 putative dimerization interface [polypeptide binding]; other site 862719003611 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719003612 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719003613 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719003614 DctM-like transporters; Region: DctM; pfam06808 862719003615 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 862719003616 active site 862719003617 catalytic residues [active] 862719003618 metal binding site [ion binding]; metal-binding site 862719003619 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719003620 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719003621 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 862719003622 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 862719003623 trimer interface [polypeptide binding]; other site 862719003624 putative metal binding site [ion binding]; other site 862719003625 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719003626 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719003627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003628 Walker A/P-loop; other site 862719003629 ATP binding site [chemical binding]; other site 862719003630 Q-loop/lid; other site 862719003631 ABC transporter signature motif; other site 862719003632 Walker B; other site 862719003633 D-loop; other site 862719003634 H-loop/switch region; other site 862719003635 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 862719003636 enolase; Provisional; Region: eno; PRK00077 862719003637 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862719003638 dimer interface [polypeptide binding]; other site 862719003639 metal binding site [ion binding]; metal-binding site 862719003640 substrate binding pocket [chemical binding]; other site 862719003641 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 862719003642 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719003643 dimer interaction site [polypeptide binding]; other site 862719003644 substrate-binding tunnel; other site 862719003645 active site 862719003646 catalytic site [active] 862719003647 substrate binding site [chemical binding]; other site 862719003648 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862719003649 Acetokinase family; Region: Acetate_kinase; cl01029 862719003650 propionate/acetate kinase; Provisional; Region: PRK12379 862719003651 EamA-like transporter family; Region: EamA; cl01037 862719003652 EamA-like transporter family; Region: EamA; cl01037 862719003653 Evidence 2b : Function of strongly homologous gene; PubMedId : 7928974; Product type e : enzyme 862719003654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003655 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 862719003656 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862719003657 Cytochrome c; Region: Cytochrom_C; cl11414 862719003658 Cytochrome c; Region: Cytochrom_C; cl11414 862719003659 Cytochrome c; Region: Cytochrom_C; cl11414 862719003660 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719003661 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719003662 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 862719003663 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 862719003664 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 862719003665 active site 862719003666 homodimer interface [polypeptide binding]; other site 862719003667 homotetramer interface [polypeptide binding]; other site 862719003668 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 862719003669 catalytic core [active] 862719003670 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719003671 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 862719003672 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719003673 Walker A/P-loop; other site 862719003674 ATP binding site [chemical binding]; other site 862719003675 Q-loop/lid; other site 862719003676 ABC transporter signature motif; other site 862719003677 Walker B; other site 862719003678 D-loop; other site 862719003679 H-loop/switch region; other site 862719003680 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719003681 ABC-ATPase subunit interface; other site 862719003682 dimer interface [polypeptide binding]; other site 862719003683 putative PBP binding regions; other site 862719003684 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719003685 ABC-ATPase subunit interface; other site 862719003686 dimer interface [polypeptide binding]; other site 862719003687 putative PBP binding regions; other site 862719003688 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 862719003689 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 862719003690 putative ligand binding residues [chemical binding]; other site 862719003691 EamA-like transporter family; Region: EamA; cl01037 862719003692 Helix-turn-helix domains; Region: HTH; cl00088 862719003693 hypothetical protein; Validated; Region: PRK09071 862719003694 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719003695 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719003696 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 862719003697 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719003698 N-terminal plug; other site 862719003699 ligand-binding site [chemical binding]; other site 862719003700 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719003701 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 862719003702 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719003703 Sel1 repeat; Region: Sel1; cl02723 862719003704 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 862719003705 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 862719003706 active site 862719003707 substrate binding site [chemical binding]; other site 862719003708 FMN binding site [chemical binding]; other site 862719003709 putative catalytic residues [active] 862719003710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 862719003711 AMP-binding enzyme; Region: AMP-binding; cl15778 862719003712 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719003713 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 862719003714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719003715 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719003716 Helix-turn-helix domains; Region: HTH; cl00088 862719003717 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719003718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719003719 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719003720 FAD binding domain; Region: FAD_binding_4; pfam01565 862719003721 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719003722 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 862719003723 substrate binding site [chemical binding]; other site 862719003724 ligand binding site [chemical binding]; other site 862719003725 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 862719003726 substrate binding site [chemical binding]; other site 862719003727 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 862719003728 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 862719003729 tetramer interface [polypeptide binding]; other site 862719003730 active site 862719003731 Mg2+/Mn2+ binding site [ion binding]; other site 862719003732 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719003733 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719003734 ligand binding site [chemical binding]; other site 862719003735 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719003736 TM-ABC transporter signature motif; other site 862719003737 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719003738 TM-ABC transporter signature motif; other site 862719003739 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719003740 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719003741 Walker A/P-loop; other site 862719003742 ATP binding site [chemical binding]; other site 862719003743 Q-loop/lid; other site 862719003744 ABC transporter signature motif; other site 862719003745 Walker B; other site 862719003746 D-loop; other site 862719003747 H-loop/switch region; other site 862719003748 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719003749 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719003750 Walker A/P-loop; other site 862719003751 ATP binding site [chemical binding]; other site 862719003752 Q-loop/lid; other site 862719003753 ABC transporter signature motif; other site 862719003754 Walker B; other site 862719003755 D-loop; other site 862719003756 H-loop/switch region; other site 862719003757 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 862719003758 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 862719003759 FAD binding pocket [chemical binding]; other site 862719003760 FAD binding motif [chemical binding]; other site 862719003761 phosphate binding motif [ion binding]; other site 862719003762 NAD binding pocket [chemical binding]; other site 862719003763 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719003764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719003765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719003766 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 862719003767 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719003768 N-terminal plug; other site 862719003769 ligand-binding site [chemical binding]; other site 862719003770 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 862719003771 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719003772 Walker A/P-loop; other site 862719003773 ATP binding site [chemical binding]; other site 862719003774 Q-loop/lid; other site 862719003775 ABC transporter signature motif; other site 862719003776 Walker B; other site 862719003777 D-loop; other site 862719003778 H-loop/switch region; other site 862719003779 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 862719003780 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 862719003781 siderophore binding site; other site 862719003782 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719003783 ABC-ATPase subunit interface; other site 862719003784 dimer interface [polypeptide binding]; other site 862719003785 putative PBP binding regions; other site 862719003786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719003787 dimer interface [polypeptide binding]; other site 862719003788 putative PBP binding regions; other site 862719003789 ABC-ATPase subunit interface; other site 862719003790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719003791 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719003792 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 862719003793 Walker A/P-loop; other site 862719003794 ATP binding site [chemical binding]; other site 862719003795 Q-loop/lid; other site 862719003796 ABC transporter signature motif; other site 862719003797 Walker B; other site 862719003798 D-loop; other site 862719003799 H-loop/switch region; other site 862719003800 BCCT family transporter; Region: BCCT; cl00569 862719003801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719003802 dimerization interface [polypeptide binding]; other site 862719003803 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003804 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003805 dimer interface [polypeptide binding]; other site 862719003806 putative CheW interface [polypeptide binding]; other site 862719003807 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 862719003808 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 862719003809 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719003810 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719003811 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719003812 K+-transporting ATPase, c chain; Region: KdpC; cl00944 862719003813 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 862719003814 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 862719003815 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 862719003816 Ligand Binding Site [chemical binding]; other site 862719003817 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 862719003818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003819 dimer interface [polypeptide binding]; other site 862719003820 phosphorylation site [posttranslational modification] 862719003821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003822 ATP binding site [chemical binding]; other site 862719003823 Mg2+ binding site [ion binding]; other site 862719003824 G-X-G motif; other site 862719003825 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 862719003826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003827 active site 862719003828 phosphorylation site [posttranslational modification] 862719003829 intermolecular recognition site; other site 862719003830 dimerization interface [polypeptide binding]; other site 862719003831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719003832 DNA binding site [nucleotide binding] 862719003833 ornithine cyclodeaminase; Validated; Region: PRK07589 862719003834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003835 Arginase family; Region: Arginase; cl00306 862719003836 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719003837 Helix-turn-helix domains; Region: HTH; cl00088 862719003838 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719003839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719003840 substrate binding pocket [chemical binding]; other site 862719003841 membrane-bound complex binding site; other site 862719003842 hinge residues; other site 862719003843 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719003844 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719003845 4Fe-4S binding domain; Region: Fer4; cl02805 862719003846 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719003847 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719003848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003849 DNA-binding site [nucleotide binding]; DNA binding site 862719003850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719003851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003852 homodimer interface [polypeptide binding]; other site 862719003853 catalytic residue [active] 862719003854 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 862719003855 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 862719003856 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 862719003857 hydrogenase 4 subunit H; Validated; Region: PRK08222 862719003858 NADH dehydrogenase; Region: NADHdh; cl00469 862719003859 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 862719003860 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719003861 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 862719003862 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719003863 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862719003864 MoaE interaction surface [polypeptide binding]; other site 862719003865 MoeB interaction surface [polypeptide binding]; other site 862719003866 thiocarboxylated glycine; other site 862719003867 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 862719003868 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 862719003869 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 862719003870 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719003871 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 862719003872 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 862719003873 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719003874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719003875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719003876 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 862719003877 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 862719003878 NADP binding site [chemical binding]; other site 862719003879 homodimer interface [polypeptide binding]; other site 862719003880 active site 862719003881 KduI/IolB family; Region: KduI; cl01508 862719003882 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 862719003883 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 862719003884 Cache domain; Region: Cache_2; cl07034 862719003885 two component system sensor kinase SsrA; Provisional; Region: PRK15347 862719003886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003887 dimerization interface [polypeptide binding]; other site 862719003888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003889 dimer interface [polypeptide binding]; other site 862719003890 putative CheW interface [polypeptide binding]; other site 862719003891 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719003892 catalytic core [active] 862719003893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719003894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719003895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003896 putative substrate translocation pore; other site 862719003897 FeoA domain; Region: FeoA; cl00838 862719003898 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 862719003899 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 862719003900 G1 box; other site 862719003901 GTP/Mg2+ binding site [chemical binding]; other site 862719003902 Switch I region; other site 862719003903 G2 box; other site 862719003904 G3 box; other site 862719003905 Switch II region; other site 862719003906 G4 box; other site 862719003907 G5 box; other site 862719003908 Nucleoside recognition; Region: Gate; cl00486 862719003909 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 862719003910 Nucleoside recognition; Region: Gate; cl00486 862719003911 manganese transport regulator MntR; Provisional; Region: PRK11050 862719003912 Helix-turn-helix domains; Region: HTH; cl00088 862719003913 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 862719003914 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 862719003915 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 862719003916 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 862719003917 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 862719003918 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 862719003919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003920 catalytic residue [active] 862719003921 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719003922 Helix-turn-helix domains; Region: HTH; cl00088 862719003923 Helix-turn-helix domains; Region: HTH; cl00088 862719003924 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 862719003925 amidase; Provisional; Region: PRK07056 862719003926 Amidase; Region: Amidase; cl11426 862719003927 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719003928 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719003929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719003930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003931 dimer interface [polypeptide binding]; other site 862719003932 conserved gate region; other site 862719003933 putative PBP binding loops; other site 862719003934 ABC-ATPase subunit interface; other site 862719003935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719003936 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719003937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719003938 Walker A/P-loop; other site 862719003939 ATP binding site [chemical binding]; other site 862719003940 Q-loop/lid; other site 862719003941 ABC transporter signature motif; other site 862719003942 Walker B; other site 862719003943 D-loop; other site 862719003944 H-loop/switch region; other site 862719003945 TOBE domain; Region: TOBE_2; cl01440 862719003946 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719003947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003948 DNA-binding site [nucleotide binding]; DNA binding site 862719003949 FCD domain; Region: FCD; cl11656 862719003950 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 862719003951 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862719003952 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862719003953 active site turn [active] 862719003954 phosphorylation site [posttranslational modification] 862719003955 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 862719003956 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 862719003957 putative active site [active] 862719003958 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719003959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003960 DNA-binding site [nucleotide binding]; DNA binding site 862719003961 UTRA domain; Region: UTRA; cl01230 862719003962 putative phosphatase; Provisional; Region: PRK11587 862719003963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719003964 active site 862719003965 motif I; other site 862719003966 motif II; other site 862719003967 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 862719003968 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 862719003969 active site 862719003970 dimer interface [polypeptide binding]; other site 862719003971 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 862719003972 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 862719003973 dimer interface [polypeptide binding]; other site 862719003974 active site 862719003975 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 862719003976 dimer interface [polypeptide binding]; other site 862719003977 active site 862719003978 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 862719003979 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862719003980 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862719003981 active site turn [active] 862719003982 phosphorylation site [posttranslational modification] 862719003983 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 862719003984 active site turn [active] 862719003985 phosphorylation site [posttranslational modification] 862719003986 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 862719003987 HPr interaction site; other site 862719003988 glycerol kinase (GK) interaction site [polypeptide binding]; other site 862719003989 active site 862719003990 phosphorylation site [posttranslational modification] 862719003991 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719003992 dimerization domain swap beta strand [polypeptide binding]; other site 862719003993 regulatory protein interface [polypeptide binding]; other site 862719003994 active site 862719003995 regulatory phosphorylation site [posttranslational modification]; other site 862719003996 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719003997 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719003998 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719003999 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719004000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719004001 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004002 dimer interface [polypeptide binding]; other site 862719004003 putative CheW interface [polypeptide binding]; other site 862719004004 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 862719004005 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862719004006 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004007 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719004008 Walker A/P-loop; other site 862719004009 ATP binding site [chemical binding]; other site 862719004010 Q-loop/lid; other site 862719004011 ABC transporter signature motif; other site 862719004012 Walker B; other site 862719004013 D-loop; other site 862719004014 H-loop/switch region; other site 862719004015 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719004016 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004017 TM-ABC transporter signature motif; other site 862719004018 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 862719004019 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719004020 putative ligand binding site [chemical binding]; other site 862719004021 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 862719004022 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 862719004023 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719004024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004025 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 862719004026 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719004027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719004028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719004029 Isochorismatase family; Region: Isochorismatase; pfam00857 862719004030 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 862719004031 catalytic triad [active] 862719004032 dimer interface [polypeptide binding]; other site 862719004033 conserved cis-peptide bond; other site 862719004034 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 862719004035 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 862719004036 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 862719004037 active site 862719004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004039 active site 862719004040 phosphorylation site [posttranslational modification] 862719004041 intermolecular recognition site; other site 862719004042 dimerization interface [polypeptide binding]; other site 862719004043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004044 DNA binding residues [nucleotide binding] 862719004045 dimerization interface [polypeptide binding]; other site 862719004046 Response regulator receiver domain; Region: Response_reg; pfam00072 862719004047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004048 active site 862719004049 phosphorylation site [posttranslational modification] 862719004050 intermolecular recognition site; other site 862719004051 dimerization interface [polypeptide binding]; other site 862719004052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719004053 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719004054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004055 dimer interface [polypeptide binding]; other site 862719004056 phosphorylation site [posttranslational modification] 862719004057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004058 ATP binding site [chemical binding]; other site 862719004059 Mg2+ binding site [ion binding]; other site 862719004060 G-X-G motif; other site 862719004061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719004062 substrate binding site [chemical binding]; other site 862719004063 activation loop (A-loop); other site 862719004064 Predicted ATPase [General function prediction only]; Region: COG3899 862719004065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719004066 GAF domain; Region: GAF_2; pfam13185 862719004067 GAF domain; Region: GAF; cl15785 862719004068 Histidine kinase; Region: HisKA_2; cl06527 862719004069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004070 ATP binding site [chemical binding]; other site 862719004071 Mg2+ binding site [ion binding]; other site 862719004072 G-X-G motif; other site 862719004073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004074 Response regulator receiver domain; Region: Response_reg; pfam00072 862719004075 active site 862719004076 phosphorylation site [posttranslational modification] 862719004077 intermolecular recognition site; other site 862719004078 dimerization interface [polypeptide binding]; other site 862719004079 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 862719004080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719004081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719004082 DNA binding residues [nucleotide binding] 862719004083 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719004084 FecR protein; Region: FecR; pfam04773 862719004085 Secretin and TonB N terminus short domain; Region: STN; cl06624 862719004086 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 862719004087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004088 N-terminal plug; other site 862719004089 ligand-binding site [chemical binding]; other site 862719004090 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 862719004091 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 862719004092 IucA / IucC family; Region: IucA_IucC; pfam04183 862719004093 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862719004094 IucA / IucC family; Region: IucA_IucC; pfam04183 862719004095 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862719004096 acyl-CoA synthetase; Validated; Region: PRK08308 862719004097 AMP-binding enzyme; Region: AMP-binding; cl15778 862719004098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719004099 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 862719004100 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 862719004101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719004102 Transposase [DNA replication, recombination, and repair]; Region: COG5433 862719004103 Transposase [DNA replication, recombination, and repair]; Region: COG5433 862719004104 Putative zinc-finger; Region: zf-HC2; cl15806 862719004105 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719004106 RNA polymerase sigma factor; Provisional; Region: PRK12547 862719004107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719004108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719004109 DNA binding residues [nucleotide binding] 862719004110 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719004111 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719004112 Walker A/P-loop; other site 862719004113 ATP binding site [chemical binding]; other site 862719004114 Q-loop/lid; other site 862719004115 ABC transporter signature motif; other site 862719004116 Walker B; other site 862719004117 D-loop; other site 862719004118 H-loop/switch region; other site 862719004119 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 862719004120 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 862719004121 putative ligand binding residues [chemical binding]; other site 862719004122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004123 ABC-ATPase subunit interface; other site 862719004124 dimer interface [polypeptide binding]; other site 862719004125 putative PBP binding regions; other site 862719004126 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719004127 dimer interface [polypeptide binding]; other site 862719004128 [2Fe-2S] cluster binding site [ion binding]; other site 862719004129 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 862719004130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004131 N-terminal plug; other site 862719004132 ligand-binding site [chemical binding]; other site 862719004133 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719004134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004135 active site 862719004136 phosphorylation site [posttranslational modification] 862719004137 intermolecular recognition site; other site 862719004138 dimerization interface [polypeptide binding]; other site 862719004139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004140 DNA binding residues [nucleotide binding] 862719004141 dimerization interface [polypeptide binding]; other site 862719004142 PAS domain; Region: PAS_9; pfam13426 862719004143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004144 dimer interface [polypeptide binding]; other site 862719004145 phosphorylation site [posttranslational modification] 862719004146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004147 ATP binding site [chemical binding]; other site 862719004148 Mg2+ binding site [ion binding]; other site 862719004149 G-X-G motif; other site 862719004150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004151 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719004152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004153 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719004154 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 862719004155 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719004156 Family description; Region: UvrD_C_2; cl15862 862719004157 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719004158 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719004159 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719004160 active site 862719004161 catalytic tetrad [active] 862719004162 PAS domain S-box; Region: sensory_box; TIGR00229 862719004163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004164 putative active site [active] 862719004165 heme pocket [chemical binding]; other site 862719004166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719004167 metal binding site [ion binding]; metal-binding site 862719004168 active site 862719004169 I-site; other site 862719004170 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719004171 Helix-turn-helix domains; Region: HTH; cl00088 862719004172 Helix-turn-helix domains; Region: HTH; cl00088 862719004173 threonine and homoserine efflux system; Provisional; Region: PRK10532 862719004174 EamA-like transporter family; Region: EamA; cl01037 862719004175 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 862719004176 Helix-turn-helix domains; Region: HTH; cl00088 862719004177 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 862719004178 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862719004179 intersubunit interface [polypeptide binding]; other site 862719004180 active site 862719004181 catalytic residue [active] 862719004182 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 862719004183 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719004184 ligand binding site [chemical binding]; other site 862719004185 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004186 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719004187 Walker A/P-loop; other site 862719004188 ATP binding site [chemical binding]; other site 862719004189 Q-loop/lid; other site 862719004190 ABC transporter signature motif; other site 862719004191 Walker B; other site 862719004192 D-loop; other site 862719004193 H-loop/switch region; other site 862719004194 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719004195 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004196 TM-ABC transporter signature motif; other site 862719004197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004198 TM-ABC transporter signature motif; other site 862719004199 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 862719004200 active site 862719004201 catalytic residues [active] 862719004202 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862719004203 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 862719004204 substrate binding site [chemical binding]; other site 862719004205 dimer interface [polypeptide binding]; other site 862719004206 ATP binding site [chemical binding]; other site 862719004207 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 862719004208 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 862719004209 N- and C-terminal domain interface [polypeptide binding]; other site 862719004210 putative active site [active] 862719004211 putative MgATP binding site [chemical binding]; other site 862719004212 catalytic site [active] 862719004213 metal binding site [ion binding]; metal-binding site 862719004214 carbohydrate binding site [chemical binding]; other site 862719004215 putative homodimer interface [polypeptide binding]; other site 862719004216 benzoate transport; Region: 2A0115; TIGR00895 862719004217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004218 putative substrate translocation pore; other site 862719004219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004220 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 862719004221 Cupin domain; Region: Cupin_2; cl09118 862719004222 Cupin domain; Region: Cupin_2; cl09118 862719004223 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 862719004224 [2Fe-2S] cluster binding site [ion binding]; other site 862719004225 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 862719004226 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719004227 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862719004228 iron-sulfur cluster [ion binding]; other site 862719004229 [2Fe-2S] cluster binding site [ion binding]; other site 862719004230 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 862719004231 putative alpha subunit interface [polypeptide binding]; other site 862719004232 putative active site [active] 862719004233 putative substrate binding site [chemical binding]; other site 862719004234 Fe binding site [ion binding]; other site 862719004235 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 862719004236 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719004237 Helix-turn-helix domains; Region: HTH; cl00088 862719004238 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719004239 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 862719004240 maleylacetoacetate isomerase; Region: maiA; TIGR01262 862719004241 C-terminal domain interface [polypeptide binding]; other site 862719004242 GSH binding site (G-site) [chemical binding]; other site 862719004243 putative dimer interface [polypeptide binding]; other site 862719004244 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 862719004245 dimer interface [polypeptide binding]; other site 862719004246 N-terminal domain interface [polypeptide binding]; other site 862719004247 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 862719004248 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719004249 Integral membrane protein TerC family; Region: TerC; cl10468 862719004250 Predicted transcriptional regulator [Transcription]; Region: COG2345 862719004251 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 862719004252 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 862719004253 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 862719004254 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 862719004255 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 862719004256 putative NAD(P) binding site [chemical binding]; other site 862719004257 homodimer interface [polypeptide binding]; other site 862719004258 homotetramer interface [polypeptide binding]; other site 862719004259 active site 862719004260 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004262 dimer interface [polypeptide binding]; other site 862719004263 conserved gate region; other site 862719004264 putative PBP binding loops; other site 862719004265 ABC-ATPase subunit interface; other site 862719004266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004267 dimer interface [polypeptide binding]; other site 862719004268 conserved gate region; other site 862719004269 ABC-ATPase subunit interface; other site 862719004270 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719004271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719004272 Walker A/P-loop; other site 862719004273 ATP binding site [chemical binding]; other site 862719004274 Q-loop/lid; other site 862719004275 ABC transporter signature motif; other site 862719004276 Walker B; other site 862719004277 D-loop; other site 862719004278 H-loop/switch region; other site 862719004279 TOBE domain; Region: TOBE_2; cl01440 862719004280 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719004281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719004282 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 862719004283 Helix-turn-helix domains; Region: HTH; cl00088 862719004284 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 862719004285 putative dimerization interface [polypeptide binding]; other site 862719004286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004287 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719004288 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719004289 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 862719004290 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719004291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004292 FAD dependent oxidoreductase; Region: DAO; pfam01266 862719004293 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719004294 homotrimer interaction site [polypeptide binding]; other site 862719004295 putative active site [active] 862719004296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004297 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719004298 substrate binding pocket [chemical binding]; other site 862719004299 membrane-bound complex binding site; other site 862719004300 hinge residues; other site 862719004301 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719004302 homotrimer interaction site [polypeptide binding]; other site 862719004303 putative active site [active] 862719004304 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 862719004305 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004306 N-terminal plug; other site 862719004307 ligand-binding site [chemical binding]; other site 862719004308 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 862719004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719004310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004311 ATP binding site [chemical binding]; other site 862719004312 Mg2+ binding site [ion binding]; other site 862719004313 G-X-G motif; other site 862719004314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719004315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004316 active site 862719004317 phosphorylation site [posttranslational modification] 862719004318 intermolecular recognition site; other site 862719004319 dimerization interface [polypeptide binding]; other site 862719004320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719004321 DNA binding site [nucleotide binding] 862719004322 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 862719004323 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719004324 Walker A/P-loop; other site 862719004325 ATP binding site [chemical binding]; other site 862719004326 ABC transporter signature motif; other site 862719004327 Walker B; other site 862719004328 D-loop; other site 862719004329 H-loop/switch region; other site 862719004330 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004331 ABC-ATPase subunit interface; other site 862719004332 dimer interface [polypeptide binding]; other site 862719004333 putative PBP binding regions; other site 862719004334 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719004335 intersubunit interface [polypeptide binding]; other site 862719004336 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 862719004337 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 862719004338 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 862719004339 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719004340 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719004341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004342 putative PBP binding loops; other site 862719004343 dimer interface [polypeptide binding]; other site 862719004344 ABC-ATPase subunit interface; other site 862719004345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719004347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719004348 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 862719004349 Walker A/P-loop; other site 862719004350 ATP binding site [chemical binding]; other site 862719004351 Q-loop/lid; other site 862719004352 ABC transporter signature motif; other site 862719004353 Walker B; other site 862719004354 D-loop; other site 862719004355 H-loop/switch region; other site 862719004356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719004357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719004358 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719004359 Walker A/P-loop; other site 862719004360 ATP binding site [chemical binding]; other site 862719004361 Q-loop/lid; other site 862719004362 ABC transporter signature motif; other site 862719004363 Walker B; other site 862719004364 D-loop; other site 862719004365 H-loop/switch region; other site 862719004366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004367 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719004368 substrate binding pocket [chemical binding]; other site 862719004369 membrane-bound complex binding site; other site 862719004370 hinge residues; other site 862719004371 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004373 dimer interface [polypeptide binding]; other site 862719004374 conserved gate region; other site 862719004375 putative PBP binding loops; other site 862719004376 ABC-ATPase subunit interface; other site 862719004377 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719004378 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 862719004379 Walker A/P-loop; other site 862719004380 ATP binding site [chemical binding]; other site 862719004381 Q-loop/lid; other site 862719004382 ABC transporter signature motif; other site 862719004383 Walker B; other site 862719004384 D-loop; other site 862719004385 H-loop/switch region; other site 862719004386 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 862719004387 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 862719004388 putative catalytic cysteine [active] 862719004389 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 862719004390 putative active site [active] 862719004391 metal binding site [ion binding]; metal-binding site 862719004392 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719004393 ligand binding site [chemical binding]; other site 862719004394 flexible hinge region; other site 862719004395 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719004396 putative switch regulator; other site 862719004397 non-specific DNA interactions [nucleotide binding]; other site 862719004398 DNA binding site [nucleotide binding] 862719004399 sequence specific DNA binding site [nucleotide binding]; other site 862719004400 putative cAMP binding site [chemical binding]; other site 862719004401 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 862719004402 response regulator FixJ; Provisional; Region: fixJ; PRK09390 862719004403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004404 active site 862719004405 phosphorylation site [posttranslational modification] 862719004406 intermolecular recognition site; other site 862719004407 dimerization interface [polypeptide binding]; other site 862719004408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004409 DNA binding residues [nucleotide binding] 862719004410 dimerization interface [polypeptide binding]; other site 862719004411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719004412 PAS domain; Region: PAS_9; pfam13426 862719004413 PAS domain S-box; Region: sensory_box; TIGR00229 862719004414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004415 putative active site [active] 862719004416 heme pocket [chemical binding]; other site 862719004417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004418 dimer interface [polypeptide binding]; other site 862719004419 phosphorylation site [posttranslational modification] 862719004420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004421 ATP binding site [chemical binding]; other site 862719004422 Mg2+ binding site [ion binding]; other site 862719004423 G-X-G motif; other site 862719004424 UV-endonuclease UvdE; Region: UvdE; cl10036 862719004425 Helix-turn-helix domains; Region: HTH; cl00088 862719004426 Predicted transcriptional regulator [Transcription]; Region: COG3355 862719004427 TIR domain; Region: TIR_2; cl15770 862719004428 Tetratricopeptide repeat; Region: TPR_10; pfam13374 862719004429 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719004430 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719004431 Walker A/P-loop; other site 862719004432 ATP binding site [chemical binding]; other site 862719004433 Q-loop/lid; other site 862719004434 ABC transporter signature motif; other site 862719004435 Walker B; other site 862719004436 D-loop; other site 862719004437 H-loop/switch region; other site 862719004438 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719004439 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004440 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004441 TM-ABC transporter signature motif; other site 862719004442 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 862719004443 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 862719004444 putative ligand binding site [chemical binding]; other site 862719004445 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 862719004446 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 862719004447 N- and C-terminal domain interface [polypeptide binding]; other site 862719004448 D-xylulose kinase; Region: XylB; TIGR01312 862719004449 active site 862719004450 catalytic site [active] 862719004451 metal binding site [ion binding]; metal-binding site 862719004452 xylulose binding site [chemical binding]; other site 862719004453 putative ATP binding site [chemical binding]; other site 862719004454 homodimer interface [polypeptide binding]; other site 862719004455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719004456 DNA binding site [nucleotide binding] 862719004457 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 862719004458 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719004459 putative ligand binding site [chemical binding]; other site 862719004460 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 862719004461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719004462 ATP binding site [chemical binding]; other site 862719004463 putative Mg++ binding site [ion binding]; other site 862719004464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719004465 Helix-turn-helix domains; Region: HTH; cl00088 862719004466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719004467 dimerization interface [polypeptide binding]; other site 862719004468 YceI-like domain; Region: YceI; cl01001 862719004469 NnrS protein; Region: NnrS; cl01258 862719004470 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719004471 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 862719004472 ligand binding site [chemical binding]; other site 862719004473 flexible hinge region; other site 862719004474 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719004475 putative switch regulator; other site 862719004476 non-specific DNA interactions [nucleotide binding]; other site 862719004477 DNA binding site [nucleotide binding] 862719004478 sequence specific DNA binding site [nucleotide binding]; other site 862719004479 putative cAMP binding site [chemical binding]; other site 862719004480 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 862719004481 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 862719004482 oxidoreductase; Provisional; Region: PRK06128 862719004483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004484 NAD(P) binding site [chemical binding]; other site 862719004485 active site 862719004486 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004487 TM-ABC transporter signature motif; other site 862719004488 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004489 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719004490 Walker A/P-loop; other site 862719004491 ATP binding site [chemical binding]; other site 862719004492 Q-loop/lid; other site 862719004493 ABC transporter signature motif; other site 862719004494 Walker B; other site 862719004495 D-loop; other site 862719004496 H-loop/switch region; other site 862719004497 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719004498 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 862719004499 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 862719004500 putative ligand binding site [chemical binding]; other site 862719004501 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 862719004502 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 862719004503 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 862719004504 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862719004505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719004506 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 862719004507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719004508 carboxyltransferase (CT) interaction site; other site 862719004509 biotinylation site [posttranslational modification]; other site 862719004510 LamB/YcsF family; Region: LamB_YcsF; cl00664 862719004511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719004512 Helix-turn-helix domains; Region: HTH; cl00088 862719004513 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 862719004514 putative substrate binding pocket [chemical binding]; other site 862719004515 dimerization interface [polypeptide binding]; other site 862719004516 SCP-2 sterol transfer family; Region: SCP2; cl01225 862719004517 Peptidase family U32; Region: Peptidase_U32; cl03113 862719004518 Peptidase family U32; Region: Peptidase_U32; cl03113 862719004519 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719004520 ApbE family; Region: ApbE; cl00643 862719004521 NosL; Region: NosL; cl01769 862719004522 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719004523 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719004524 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 862719004525 Walker A/P-loop; other site 862719004526 ATP binding site [chemical binding]; other site 862719004527 Q-loop/lid; other site 862719004528 ABC transporter signature motif; other site 862719004529 Walker B; other site 862719004530 D-loop; other site 862719004531 H-loop/switch region; other site 862719004532 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 862719004533 nitrous-oxide reductase; Validated; Region: PRK02888 862719004534 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719004535 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 862719004536 FMN-binding domain; Region: FMN_bind; cl01081 862719004537 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 862719004538 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719004539 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862719004540 active site 862719004541 catalytic residues [active] 862719004542 Evidence 2b : Function of strongly homologous gene; PubMedId : 7639719; Product type f : factor 862719004543 ferredoxin-type protein NapF; Region: napF; TIGR00402 862719004544 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 862719004545 NapD protein; Region: NapD; cl01163 862719004546 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 862719004547 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719004548 [4Fe-4S] binding site [ion binding]; other site 862719004549 molybdopterin cofactor binding site; other site 862719004550 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719004551 molybdopterin cofactor binding site; other site 862719004552 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 862719004553 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 862719004554 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 862719004555 ParB-like nuclease domain; Region: ParBc; cl02129 862719004556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719004557 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719004558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004559 P-loop; other site 862719004560 Magnesium ion binding site [ion binding]; other site 862719004561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004562 Magnesium ion binding site [ion binding]; other site 862719004563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719004564 DNA-binding site [nucleotide binding]; DNA binding site 862719004565 RNA-binding motif; other site 862719004566 ParA-like protein; Provisional; Region: PHA02518 862719004567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004568 P-loop; other site 862719004569 Magnesium ion binding site [ion binding]; other site 862719004570 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 862719004571 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 862719004572 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719004573 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719004574 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719004575 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719004576 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719004577 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719004578 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier 862719004579 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004581 binding surface 862719004582 TPR motif; other site 862719004583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004584 binding surface 862719004585 TPR motif; other site 862719004586 TPR repeat; Region: TPR_11; pfam13414 862719004587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004588 binding surface 862719004589 TPR motif; other site 862719004590 TPR repeat; Region: TPR_11; pfam13414 862719004591 hypothetical protein; Provisional; Region: PRK08317 862719004592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719004593 S-adenosylmethionine binding site [chemical binding]; other site 862719004594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004596 binding surface 862719004597 TPR motif; other site 862719004598 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004599 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004600 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 862719004601 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 862719004602 NADP binding site [chemical binding]; other site 862719004603 active site 862719004604 putative substrate binding site [chemical binding]; other site 862719004605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004607 binding surface 862719004608 TPR motif; other site 862719004609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719004610 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719004611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004612 binding surface 862719004613 TPR motif; other site 862719004614 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004615 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 862719004616 putative active site [active] 862719004617 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 862719004618 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719004619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719004620 Walker A/P-loop; other site 862719004621 ATP binding site [chemical binding]; other site 862719004622 Q-loop/lid; other site 862719004623 ABC transporter signature motif; other site 862719004624 Walker B; other site 862719004625 D-loop; other site 862719004626 H-loop/switch region; other site 862719004627 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719004628 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004629 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004630 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719004631 Sel1 repeat; Region: Sel1; cl02723 862719004632 Sel1 repeat; Region: Sel1; cl02723 862719004633 Sel1 repeat; Region: Sel1; cl02723 862719004634 Sel1 repeat; Region: Sel1; cl02723 862719004635 Sel1 repeat; Region: Sel1; cl02723 862719004636 Sel1 repeat; Region: Sel1; cl02723 862719004637 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719004638 ADP-ribose binding site [chemical binding]; other site 862719004639 dimer interface [polypeptide binding]; other site 862719004640 active site 862719004641 nudix motif; other site 862719004642 metal binding site [ion binding]; metal-binding site 862719004643 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 862719004644 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 862719004645 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 862719004646 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862719004647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719004648 FeS/SAM binding site; other site 862719004649 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 862719004650 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 862719004651 NADP binding site [chemical binding]; other site 862719004652 active site 862719004653 putative substrate binding site [chemical binding]; other site 862719004654 Autophagy protein 16 (ATG16); Region: ATG16; pfam08614 862719004655 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 862719004656 ligand-binding site [chemical binding]; other site 862719004657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719004658 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862719004659 hypothetical protein; Provisional; Region: PRK05849 862719004660 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719004661 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 862719004662 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 862719004663 catalytic triad [active] 862719004664 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 862719004665 active site 862719004666 metal-binding site 862719004667 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 862719004668 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 862719004669 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 862719004670 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 862719004671 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 862719004672 catalytic core [active] 862719004673 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 862719004674 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 862719004675 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 862719004676 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862719004677 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 862719004678 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719004679 inhibitor-cofactor binding pocket; inhibition site 862719004680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719004681 catalytic residue [active] 862719004682 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719004683 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719004684 alpha subunit interface [polypeptide binding]; other site 862719004685 TPP binding site [chemical binding]; other site 862719004686 heterodimer interface [polypeptide binding]; other site 862719004687 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719004688 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719004689 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719004690 tetramer interface [polypeptide binding]; other site 862719004691 TPP-binding site [chemical binding]; other site 862719004692 heterodimer interface [polypeptide binding]; other site 862719004693 phosphorylation loop region [posttranslational modification] 862719004694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719004695 extended (e) SDRs; Region: SDR_e; cd08946 862719004696 NAD(P) binding site [chemical binding]; other site 862719004697 active site 862719004698 substrate binding site [chemical binding]; other site 862719004699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004700 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719004701 Substrate binding site; other site 862719004702 Mg++ binding site; other site 862719004703 metal-binding site 862719004704 Mg++ binding site; other site 862719004705 metal-binding site 862719004706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719004707 active site 862719004708 motif I; other site 862719004709 motif II; other site 862719004710 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719004711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004712 binding surface 862719004713 TPR motif; other site 862719004714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004715 binding surface 862719004716 TPR motif; other site 862719004717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004718 binding surface 862719004719 TPR motif; other site 862719004720 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004722 binding surface 862719004723 TPR motif; other site 862719004724 TPR repeat; Region: TPR_11; pfam13414 862719004725 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719004726 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719004728 S-adenosylmethionine binding site [chemical binding]; other site 862719004729 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862719004730 active site 862719004731 catalytic site [active] 862719004732 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 862719004733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719004734 motif II; other site 862719004735 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 862719004736 Ligand binding site; other site 862719004737 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 862719004738 Ligand binding site; other site 862719004739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719004740 active site 862719004741 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 862719004742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004743 binding surface 862719004744 TPR repeat; Region: TPR_11; pfam13414 862719004745 TPR motif; other site 862719004746 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719004747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004748 binding surface 862719004749 TPR motif; other site 862719004750 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 862719004751 dimer interface [polypeptide binding]; other site 862719004752 active site 862719004753 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004755 binding surface 862719004756 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004757 TPR motif; other site 862719004758 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004760 TPR motif; other site 862719004761 TPR repeat; Region: TPR_11; pfam13414 862719004762 binding surface 862719004763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719004764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004765 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004766 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719004767 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719004768 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 862719004769 active site 862719004770 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719004771 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 862719004772 active site 862719004773 putative substrate binding region [chemical binding]; other site 862719004774 potassium/proton antiporter; Reviewed; Region: PRK05326 862719004775 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 862719004776 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004777 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004778 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 862719004779 PemK-like protein; Region: PemK; cl00995 862719004780 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004781 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004782 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004783 multidrug resistance protein MdtN; Provisional; Region: PRK10476 862719004784 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719004785 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 862719004786 Sporulation related domain; Region: SPOR; cl10051 862719004787 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 862719004788 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 862719004789 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 862719004790 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 862719004791 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 862719004792 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 862719004793 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 862719004794 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719004795 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719004796 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 862719004797 Phage Tail Collar Domain; Region: Collar; pfam07484 862719004798 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719004799 Evidence 2b : Function of strongly homologous gene 862719004800 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 862719004801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004802 binding surface 862719004803 TPR motif; other site 862719004804 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719004805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719004806 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719004807 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 862719004808 ligand binding site; other site 862719004809 tetramer interface; other site 862719004810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004811 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719004812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719004813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004814 NAD(P) binding site [chemical binding]; other site 862719004815 active site 862719004816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004817 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862719004818 NAD(P) binding site [chemical binding]; other site 862719004819 active site 862719004820 Cupin domain; Region: Cupin_2; cl09118 862719004821 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 862719004822 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862719004823 B12 binding site [chemical binding]; other site 862719004824 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862719004825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719004826 FeS/SAM binding site; other site 862719004827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004828 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 862719004829 NAD(P) binding site [chemical binding]; other site 862719004830 active site 862719004831 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 862719004832 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 862719004833 active site 862719004834 homodimer interface [polypeptide binding]; other site 862719004835 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 862719004836 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719004837 inhibitor-cofactor binding pocket; inhibition site 862719004838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719004839 catalytic residue [active] 862719004840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719004841 active site 862719004842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719004843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719004845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004846 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 862719004847 active site 862719004848 cosubstrate binding site; other site 862719004849 catalytic site [active] 862719004850 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 862719004851 NeuB family; Region: NeuB; cl00496 862719004852 SAF domain; Region: SAF; cl00555 862719004853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004854 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719004855 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 862719004856 dimer interface [polypeptide binding]; other site 862719004857 active site 862719004858 CoA binding pocket [chemical binding]; other site 862719004859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719004860 salt bridge; other site 862719004861 non-specific DNA binding site [nucleotide binding]; other site 862719004862 sequence-specific DNA binding site [nucleotide binding]; other site 862719004863 potential frameshift: common BLAST hit: gi|288963057|ref|YP_003453336.1| hipA domain protein 862719004864 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 862719004865 HipA N-terminal domain; Region: Couple_hipA; cl11853 862719004866 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719004867 classical (c) SDRs; Region: SDR_c; cd05233 862719004868 NAD(P) binding site [chemical binding]; other site 862719004869 active site 862719004870 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 862719004871 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 862719004872 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 862719004873 oligomeric interface; other site 862719004874 putative active site [active] 862719004875 homodimer interface [polypeptide binding]; other site 862719004876 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719004877 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719004878 [2Fe-2S] cluster binding site [ion binding]; other site 862719004879 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 862719004880 alpha subunit interface [polypeptide binding]; other site 862719004881 active site 862719004882 substrate binding site [chemical binding]; other site 862719004883 Fe binding site [ion binding]; other site 862719004884 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 862719004885 Asp-box motif; other site 862719004886 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719004887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719004888 active site 862719004889 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 862719004890 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 862719004891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719004892 active site 862719004893 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719004894 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719004895 dimer interface [polypeptide binding]; other site 862719004896 ADP-ribose binding site [chemical binding]; other site 862719004897 active site 862719004898 nudix motif; other site 862719004899 metal binding site [ion binding]; metal-binding site 862719004900 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 862719004901 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719004902 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719004903 catalytic residues [active] 862719004904 catalytic nucleophile [active] 862719004905 Recombinase; Region: Recombinase; pfam07508 862719004906 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719004907 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719004908 Helix-turn-helix domains; Region: HTH; cl00088 862719004909 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719004910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 862719004911 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 862719004912 Substrate binding site; other site 862719004913 metal-binding site 862719004914 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 862719004915 Ligand Binding Site [chemical binding]; other site 862719004916 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719004917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004919 Transposase domain (DUF772); Region: DUF772; cl15789 862719004920 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 862719004921 Integrase core domain; Region: rve; cl01316 862719004922 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719004923 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 862719004924 Helix-turn-helix domains; Region: HTH; cl00088 862719004925 Transposase domain (DUF772); Region: DUF772; cl15789 862719004926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004928 NAD(P) binding site [chemical binding]; other site 862719004929 active site 862719004930 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 862719004931 substrate binding site; other site 862719004932 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 862719004933 ligand binding site; other site 862719004934 tetramer interface; other site 862719004935 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 862719004936 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 862719004937 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 862719004938 putative active site [active] 862719004939 oxyanion strand; other site 862719004940 catalytic triad [active] 862719004941 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 862719004942 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 862719004943 substrate binding site [chemical binding]; other site 862719004944 glutamase interaction surface [polypeptide binding]; other site 862719004945 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862719004946 extended (e) SDRs; Region: SDR_e; cd08946 862719004947 NAD(P) binding site [chemical binding]; other site 862719004948 active site 862719004949 substrate binding site [chemical binding]; other site 862719004950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004951 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719004952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 862719004953 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719004954 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719004955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004956 TPR motif; other site 862719004957 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719004958 binding surface 862719004959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719004960 binding surface 862719004961 TPR motif; other site 862719004962 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719004963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719004964 S-adenosylmethionine binding site [chemical binding]; other site 862719004965 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719004966 Ligand binding site; other site 862719004967 Putative Catalytic site; other site 862719004968 DXD motif; other site 862719004969 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 862719004970 Right handed beta helix region; Region: Beta_helix; pfam13229 862719004971 Right handed beta helix region; Region: Beta_helix; pfam13229 862719004972 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719004973 AMIN domain; Region: AMIN; pfam11741 862719004974 Uncharacterized conserved protein [Function unknown]; Region: COG1739 862719004975 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 862719004976 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 862719004977 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719004978 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 862719004979 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 862719004980 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719004981 inhibitor-cofactor binding pocket; inhibition site 862719004982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719004983 catalytic residue [active] 862719004984 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 862719004985 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 862719004986 NAD(P) binding site [chemical binding]; other site 862719004987 homodimer interface [polypeptide binding]; other site 862719004988 substrate binding site [chemical binding]; other site 862719004989 active site 862719004990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719004991 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 862719004992 putative ADP-binding pocket [chemical binding]; other site 862719004993 Cupin domain; Region: Cupin_2; cl09118 862719004994 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719004995 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862719004996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 862719004997 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 862719004998 Probable transposase; Region: OrfB_IS605; pfam01385 862719004999 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 862719005000 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 862719005001 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 862719005002 Substrate binding site; other site 862719005003 Cupin domain; Region: Cupin_2; cl09118 862719005004 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 862719005005 Protein of unknown function (DUF497); Region: DUF497; cl01108 862719005006 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 862719005007 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 862719005008 putative active site [active] 862719005009 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719005010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719005011 Walker A/P-loop; other site 862719005012 ATP binding site [chemical binding]; other site 862719005013 Q-loop/lid; other site 862719005014 ABC transporter signature motif; other site 862719005015 Walker B; other site 862719005016 D-loop; other site 862719005017 H-loop/switch region; other site 862719005018 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719005019 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719005020 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719005021 GtrA-like protein; Region: GtrA; cl00971 862719005022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719005023 active site 862719005024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719005025 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 862719005026 NAD binding site [chemical binding]; other site 862719005027 putative substrate binding site 2 [chemical binding]; other site 862719005028 putative substrate binding site 1 [chemical binding]; other site 862719005029 active site 862719005030 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 862719005031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005032 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719005033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005034 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862719005035 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862719005036 NAD binding site [chemical binding]; other site 862719005037 homodimer interface [polypeptide binding]; other site 862719005038 active site 862719005039 substrate binding site [chemical binding]; other site 862719005040 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 862719005041 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 862719005042 substrate binding site; other site 862719005043 tetramer interface; other site 862719005044 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 862719005045 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 862719005046 NADP binding site [chemical binding]; other site 862719005047 active site 862719005048 putative substrate binding site [chemical binding]; other site 862719005049 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 862719005050 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 862719005051 NAD binding site [chemical binding]; other site 862719005052 substrate binding site [chemical binding]; other site 862719005053 homodimer interface [polypeptide binding]; other site 862719005054 active site 862719005055 Cupin domain; Region: Cupin_2; cl09118 862719005056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005057 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862719005058 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 862719005059 Probable Catalytic site; other site 862719005060 metal-binding site 862719005061 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719005062 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719005063 Probable Catalytic site; other site 862719005064 metal-binding site 862719005065 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 862719005066 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 862719005067 Walker A/P-loop; other site 862719005068 ATP binding site [chemical binding]; other site 862719005069 Q-loop/lid; other site 862719005070 ABC transporter signature motif; other site 862719005071 Walker B; other site 862719005072 D-loop; other site 862719005073 H-loop/switch region; other site 862719005074 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 862719005075 putative carbohydrate binding site [chemical binding]; other site 862719005076 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719005077 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 862719005078 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 862719005079 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719005080 Active Sites [active] 862719005081 Evidence 7 : Gene remnant; Product type e : enzyme 862719005082 Evidence 7 : Gene remnant; Product type e : enzyme 862719005083 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719005084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005085 TPR motif; other site 862719005086 binding surface 862719005087 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 862719005088 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 862719005089 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 862719005090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005091 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719005092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005093 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719005094 active site 862719005095 NTP binding site [chemical binding]; other site 862719005096 metal binding triad [ion binding]; metal-binding site 862719005097 antibiotic binding site [chemical binding]; other site 862719005098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719005099 non-specific DNA binding site [nucleotide binding]; other site 862719005100 salt bridge; other site 862719005101 sequence-specific DNA binding site [nucleotide binding]; other site 862719005102 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 862719005103 translation initiation factor IF-3; Region: infC; TIGR00168 862719005104 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862719005105 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862719005106 PAS domain S-box; Region: sensory_box; TIGR00229 862719005107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005108 putative active site [active] 862719005109 heme pocket [chemical binding]; other site 862719005110 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719005111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005112 ATP binding site [chemical binding]; other site 862719005113 Mg2+ binding site [ion binding]; other site 862719005114 G-X-G motif; other site 862719005115 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005117 active site 862719005118 phosphorylation site [posttranslational modification] 862719005119 intermolecular recognition site; other site 862719005120 dimerization interface [polypeptide binding]; other site 862719005121 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 862719005122 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719005123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005124 dimer interface [polypeptide binding]; other site 862719005125 phosphorylation site [posttranslational modification] 862719005126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005127 ATP binding site [chemical binding]; other site 862719005128 Mg2+ binding site [ion binding]; other site 862719005129 G-X-G motif; other site 862719005130 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005132 active site 862719005133 phosphorylation site [posttranslational modification] 862719005134 intermolecular recognition site; other site 862719005135 dimerization interface [polypeptide binding]; other site 862719005136 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 862719005137 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 862719005138 DNA binding residues [nucleotide binding] 862719005139 dimer interface [polypeptide binding]; other site 862719005140 putative metal binding site [ion binding]; other site 862719005141 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719005142 metal-binding site [ion binding] 862719005143 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 862719005144 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719005145 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719005146 Protein of unknown function, DUF; Region: DUF411; cl01142 862719005147 OpgC protein; Region: OpgC_C; cl00792 862719005148 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719005149 Substrate binding site; other site 862719005150 Mg++ binding site; other site 862719005151 metal-binding site 862719005152 Mg++ binding site; other site 862719005153 metal-binding site 862719005154 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 862719005155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719005156 motif I; other site 862719005157 motif II; other site 862719005158 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719005159 catalytic residues [active] 862719005160 catalytic nucleophile [active] 862719005161 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719005162 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719005163 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719005164 Synaptic Site I dimer interface [polypeptide binding]; other site 862719005165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005166 TPR motif; other site 862719005167 TPR repeat; Region: TPR_11; pfam13414 862719005168 binding surface 862719005169 Tetratricopeptide repeat; Region: TPR_9; pfam13371 862719005170 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719005171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719005172 NB-ARC domain; Region: NB-ARC; pfam00931 862719005173 Walker A motif; other site 862719005174 ATP binding site [chemical binding]; other site 862719005175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005177 binding surface 862719005178 TPR motif; other site 862719005179 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005181 binding surface 862719005182 TPR motif; other site 862719005183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005184 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005186 binding surface 862719005187 TPR motif; other site 862719005188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005189 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719005190 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719005191 P-loop; other site 862719005192 Magnesium ion binding site [ion binding]; other site 862719005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005194 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719005195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005196 TPR motif; other site 862719005197 binding surface 862719005198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005199 TPR repeat; Region: TPR_11; pfam13414 862719005200 binding surface 862719005201 TPR motif; other site 862719005202 TPR repeat; Region: TPR_11; pfam13414 862719005203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005204 binding surface 862719005205 TPR motif; other site 862719005206 ADP-heptose:LPS heptosyltransferase II; Provisional; Region: PRK10916; cl15782 862719005207 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 862719005208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005209 S-adenosylmethionine binding site [chemical binding]; other site 862719005210 tocopherol O-methyltransferase; Region: PLN02244 862719005211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005212 S-adenosylmethionine binding site [chemical binding]; other site 862719005213 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 862719005214 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 862719005215 Ligand binding site; other site 862719005216 Putative Catalytic site; other site 862719005217 DXD motif; other site 862719005218 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 862719005219 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719005220 active site 862719005221 dimer interface [polypeptide binding]; other site 862719005222 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719005223 Ligand Binding Site [chemical binding]; other site 862719005224 Molecular Tunnel; other site 862719005225 Transposase domain (DUF772); Region: DUF772; cl15789 862719005226 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719005227 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 862719005228 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719005229 inhibitor-cofactor binding pocket; inhibition site 862719005230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719005231 catalytic residue [active] 862719005232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719005233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005234 NAD(P) binding site [chemical binding]; other site 862719005235 active site 862719005236 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719005237 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 862719005238 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719005239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719005243 active site 862719005244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005245 binding surface 862719005246 TPR motif; other site 862719005247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005249 binding surface 862719005250 TPR motif; other site 862719005251 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 862719005252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005253 S-adenosylmethionine binding site [chemical binding]; other site 862719005254 TPR repeat; Region: TPR_11; pfam13414 862719005255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005256 binding surface 862719005257 TPR motif; other site 862719005258 TPR repeat; Region: TPR_11; pfam13414 862719005259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005260 binding surface 862719005261 TPR motif; other site 862719005262 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719005263 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 862719005264 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 862719005265 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 862719005266 NADP-binding site; other site 862719005267 homotetramer interface [polypeptide binding]; other site 862719005268 substrate binding site [chemical binding]; other site 862719005269 homodimer interface [polypeptide binding]; other site 862719005270 active site 862719005271 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8793876, 15033235; Product type e : enzyme 862719005272 Evidence 2b : Function of strongly homologous gene; Product type s : structure 862719005273 DnaA N-terminal domain; Region: DnaA_N; pfam11638 862719005274 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 862719005275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719005276 Walker A motif; other site 862719005277 ATP binding site [chemical binding]; other site 862719005278 Walker B motif; other site 862719005279 arginine finger; other site 862719005280 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 862719005281 DnaA box-binding interface [nucleotide binding]; other site 862719005282 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005284 active site 862719005285 phosphorylation site [posttranslational modification] 862719005286 intermolecular recognition site; other site 862719005287 dimerization interface [polypeptide binding]; other site 862719005288 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005289 metal binding site [ion binding]; metal-binding site 862719005290 active site 862719005291 I-site; other site 862719005292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719005293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005294 dimer interface [polypeptide binding]; other site 862719005295 phosphorylation site [posttranslational modification] 862719005296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005297 ATP binding site [chemical binding]; other site 862719005298 Mg2+ binding site [ion binding]; other site 862719005299 G-X-G motif; other site 862719005300 osmolarity response regulator; Provisional; Region: ompR; PRK09468 862719005301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005302 active site 862719005303 phosphorylation site [posttranslational modification] 862719005304 intermolecular recognition site; other site 862719005305 dimerization interface [polypeptide binding]; other site 862719005306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719005307 DNA binding site [nucleotide binding] 862719005308 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 862719005309 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 862719005310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719005311 nucleotide binding region [chemical binding]; other site 862719005312 ATP-binding site [chemical binding]; other site 862719005313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719005314 RNA binding surface [nucleotide binding]; other site 862719005315 Tim44-like domain; Region: Tim44; cl09208 862719005316 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719005317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719005318 Walker A/P-loop; other site 862719005319 ATP binding site [chemical binding]; other site 862719005320 Q-loop/lid; other site 862719005321 ABC transporter signature motif; other site 862719005322 Walker B; other site 862719005323 D-loop; other site 862719005324 H-loop/switch region; other site 862719005325 TOBE domain; Region: TOBE_2; cl01440 862719005326 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719005327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719005328 Transglycosylase; Region: Transgly; cl07896 862719005329 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 862719005330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719005331 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 862719005332 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719005333 ligand binding site [chemical binding]; other site 862719005334 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 862719005335 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719005336 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 862719005337 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719005338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005339 binding surface 862719005340 TPR motif; other site 862719005341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005343 binding surface 862719005344 TPR motif; other site 862719005345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719005346 binding surface 862719005347 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719005348 TPR motif; other site 862719005349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005350 S-adenosylmethionine binding site [chemical binding]; other site 862719005351 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 862719005352 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 862719005353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719005354 FeS/SAM binding site; other site 862719005355 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 862719005356 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 862719005357 oligomerization interface [polypeptide binding]; other site 862719005358 active site 862719005359 NAD+ binding site [chemical binding]; other site 862719005360 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 862719005361 CcdB protein; Region: CcdB; cl03380 862719005362 HI0933-like protein; Region: HI0933_like; pfam03486 862719005363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005365 Bacterial SH3 domain; Region: SH3_3; cl02551 862719005366 Bacterial SH3 domain; Region: SH3_3; cl02551 862719005367 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719005368 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 862719005369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719005370 active site 862719005371 motif I; other site 862719005372 motif II; other site 862719005373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719005374 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 862719005375 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 862719005376 putative ADP-binding pocket [chemical binding]; other site 862719005377 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719005378 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719005379 Evidence 7 : Gene remnant; Product type pe : putative enzyme 862719005380 Evidence 7 : Gene remnant; Product type pe : putative enzyme 862719005381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719005382 Helix-turn-helix domains; Region: HTH; cl00088 862719005383 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719005384 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 862719005385 putative catalytic site [active] 862719005386 putative phosphate binding site [ion binding]; other site 862719005387 active site 862719005388 metal binding site A [ion binding]; metal-binding site 862719005389 DNA binding site [nucleotide binding] 862719005390 putative AP binding site [nucleotide binding]; other site 862719005391 putative metal binding site B [ion binding]; other site 862719005392 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719005393 catalytic core [active] 862719005394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 862719005395 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719005396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719005397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719005398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005399 active site 862719005400 phosphorylation site [posttranslational modification] 862719005401 intermolecular recognition site; other site 862719005402 dimerization interface [polypeptide binding]; other site 862719005403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719005404 DNA binding site [nucleotide binding] 862719005405 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 862719005406 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 862719005407 dimerization interface [polypeptide binding]; other site 862719005408 active site 862719005409 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719005410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 862719005411 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719005412 catalytic residue [active] 862719005413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 862719005414 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 862719005415 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 862719005416 trimer interface [polypeptide binding]; other site 862719005417 eyelet of channel; other site 862719005418 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 862719005419 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 862719005420 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 862719005421 HIGH motif; other site 862719005422 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862719005423 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719005424 active site 862719005425 KMSKS motif; other site 862719005426 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 862719005427 tRNA binding surface [nucleotide binding]; other site 862719005428 Lipopolysaccharide-assembly; Region: LptE; cl01125 862719005429 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 862719005430 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 862719005431 TspO/MBR family; Region: TspO_MBR; cl01379 862719005432 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 862719005433 GIY-YIG motif/motif A; other site 862719005434 Helix-turn-helix domains; Region: HTH; cl00088 862719005435 Helix-turn-helix domains; Region: HTH; cl00088 862719005436 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719005437 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 862719005438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719005439 FeS/SAM binding site; other site 862719005440 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 862719005441 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862719005442 active site 862719005443 catalytic site [active] 862719005444 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719005445 FMN binding site [chemical binding]; other site 862719005446 substrate binding site [chemical binding]; other site 862719005447 putative catalytic residue [active] 862719005448 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719005449 metal binding site 2 [ion binding]; metal-binding site 862719005450 putative DNA binding helix; other site 862719005451 metal binding site 1 [ion binding]; metal-binding site 862719005452 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719005453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005454 putative active site [active] 862719005455 heme pocket [chemical binding]; other site 862719005456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005457 dimer interface [polypeptide binding]; other site 862719005458 phosphorylation site [posttranslational modification] 862719005459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005460 ATP binding site [chemical binding]; other site 862719005461 Mg2+ binding site [ion binding]; other site 862719005462 G-X-G motif; other site 862719005463 Sodium:solute symporter family; Region: SSF; cl00456 862719005464 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 862719005465 Protein of unknown function, DUF485; Region: DUF485; cl01231 862719005466 Cache domain; Region: Cache_2; cl07034 862719005467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 862719005468 Cache domain; Region: Cache_2; cl07034 862719005469 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 862719005470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719005471 dimerization interface [polypeptide binding]; other site 862719005472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719005473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719005474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005475 dimer interface [polypeptide binding]; other site 862719005476 phosphorylation site [posttranslational modification] 862719005477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005478 ATP binding site [chemical binding]; other site 862719005479 Mg2+ binding site [ion binding]; other site 862719005480 G-X-G motif; other site 862719005481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005482 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005483 active site 862719005484 phosphorylation site [posttranslational modification] 862719005485 intermolecular recognition site; other site 862719005486 dimerization interface [polypeptide binding]; other site 862719005487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719005488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005489 active site 862719005490 phosphorylation site [posttranslational modification] 862719005491 intermolecular recognition site; other site 862719005492 dimerization interface [polypeptide binding]; other site 862719005493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719005494 DNA binding site [nucleotide binding] 862719005495 acyl-CoA synthetase; Validated; Region: PRK08162 862719005496 AMP-binding enzyme; Region: AMP-binding; cl15778 862719005497 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719005498 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719005499 Ligand binding site [chemical binding]; other site 862719005500 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719005501 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719005502 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719005503 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719005504 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 862719005505 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719005506 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719005507 active site 862719005508 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719005509 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 862719005510 pseudouridine synthase; Region: TIGR00093 862719005511 active site 862719005512 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 862719005513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005514 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719005515 Helix-turn-helix domains; Region: HTH; cl00088 862719005516 Helix-turn-helix domains; Region: HTH; cl00088 862719005517 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 862719005518 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719005519 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 862719005520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005521 S-adenosylmethionine binding site [chemical binding]; other site 862719005522 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 862719005523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719005524 active site 862719005525 DNA binding site [nucleotide binding] 862719005526 Int/Topo IB signature motif; other site 862719005527 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 862719005528 ribosomal protein L20; Region: rpl20; CHL00068 862719005529 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 862719005530 23S rRNA binding site [nucleotide binding]; other site 862719005531 L21 binding site [polypeptide binding]; other site 862719005532 L13 binding site [polypeptide binding]; other site 862719005533 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 862719005534 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 862719005535 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 862719005536 dimer interface [polypeptide binding]; other site 862719005537 motif 1; other site 862719005538 active site 862719005539 motif 2; other site 862719005540 motif 3; other site 862719005541 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 862719005542 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 862719005543 putative tRNA-binding site [nucleotide binding]; other site 862719005544 B3/4 domain; Region: B3_4; cl11458 862719005545 tRNA synthetase B5 domain; Region: B5; cl08394 862719005546 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 862719005547 dimer interface [polypeptide binding]; other site 862719005548 motif 1; other site 862719005549 motif 3; other site 862719005550 motif 2; other site 862719005551 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 862719005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005553 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005554 active site 862719005555 phosphorylation site [posttranslational modification] 862719005556 intermolecular recognition site; other site 862719005557 dimerization interface [polypeptide binding]; other site 862719005558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005559 active site 862719005560 phosphorylation site [posttranslational modification] 862719005561 intermolecular recognition site; other site 862719005562 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719005563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719005564 Zn2+ binding site [ion binding]; other site 862719005565 Mg2+ binding site [ion binding]; other site 862719005566 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 862719005567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719005568 Helix-turn-helix domains; Region: HTH; cl00088 862719005569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719005570 dimerization interface [polypeptide binding]; other site 862719005571 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 862719005572 active site 862719005573 homodimer interface [polypeptide binding]; other site 862719005574 GTP-binding protein LepA; Provisional; Region: PRK05433 862719005575 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 862719005576 G1 box; other site 862719005577 putative GEF interaction site [polypeptide binding]; other site 862719005578 GTP/Mg2+ binding site [chemical binding]; other site 862719005579 Switch I region; other site 862719005580 G2 box; other site 862719005581 G3 box; other site 862719005582 Switch II region; other site 862719005583 G4 box; other site 862719005584 G5 box; other site 862719005585 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 862719005586 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 862719005587 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 862719005588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005591 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719005592 glycogen synthase; Provisional; Region: glgA; PRK00654 862719005593 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 862719005594 ADP-binding pocket [chemical binding]; other site 862719005595 homodimer interface [polypeptide binding]; other site 862719005596 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 862719005597 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 862719005598 ligand binding site; other site 862719005599 oligomer interface; other site 862719005600 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 862719005601 dimer interface [polypeptide binding]; other site 862719005602 N-terminal domain interface [polypeptide binding]; other site 862719005603 sulfate 1 binding site; other site 862719005604 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 862719005605 Pirin-related protein [General function prediction only]; Region: COG1741 862719005606 Cupin domain; Region: Cupin_2; cl09118 862719005607 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 862719005608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005609 putative active site [active] 862719005610 PAS fold; Region: PAS_3; pfam08447 862719005611 heme pocket [chemical binding]; other site 862719005612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005613 metal binding site [ion binding]; metal-binding site 862719005614 active site 862719005615 I-site; other site 862719005616 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719005617 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 862719005618 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 862719005619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719005620 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 862719005621 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 862719005622 active site 862719005623 DNA binding site [nucleotide binding] 862719005624 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 862719005625 DNA binding site [nucleotide binding] 862719005626 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719005627 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 862719005628 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 862719005629 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 862719005630 Helix-turn-helix domains; Region: HTH; cl00088 862719005631 Chromate transporter; Region: Chromate_transp; pfam02417 862719005632 Chromate transporter; Region: Chromate_transp; pfam02417 862719005633 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862719005634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719005635 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 862719005636 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862719005637 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719005638 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 862719005639 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719005640 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719005641 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 862719005642 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719005643 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719005644 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 862719005645 IMP binding site; other site 862719005646 dimer interface [polypeptide binding]; other site 862719005647 partial ornithine binding site; other site 862719005648 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 862719005649 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 862719005650 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 862719005651 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719005652 [4Fe-4S] binding site [ion binding]; other site 862719005653 molybdopterin cofactor binding site; other site 862719005654 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719005655 molybdopterin cofactor binding site; other site 862719005656 NapD protein; Region: NapD; cl01163 862719005657 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 862719005658 MgtC family; Region: MgtC; pfam02308 862719005659 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719005660 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719005661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719005662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005663 dimer interface [polypeptide binding]; other site 862719005664 phosphorylation site [posttranslational modification] 862719005665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005666 ATP binding site [chemical binding]; other site 862719005667 Mg2+ binding site [ion binding]; other site 862719005668 G-X-G motif; other site 862719005669 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719005670 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719005671 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719005672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005673 dimer interface [polypeptide binding]; other site 862719005674 phosphorylation site [posttranslational modification] 862719005675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005676 ATP binding site [chemical binding]; other site 862719005677 Mg2+ binding site [ion binding]; other site 862719005678 G-X-G motif; other site 862719005679 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719005680 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 862719005681 DinB superfamily; Region: DinB_2; pfam12867 862719005682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719005683 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 862719005684 PAS fold; Region: PAS_4; pfam08448 862719005685 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 862719005686 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862719005687 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 862719005688 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719005689 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719005690 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 862719005691 OpgC protein; Region: OpgC_C; cl00792 862719005692 Acyltransferase family; Region: Acyl_transf_3; pfam01757 862719005693 Helix-turn-helix domains; Region: HTH; cl00088 862719005694 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862719005695 glucokinase, proteobacterial type; Region: glk; TIGR00749 862719005696 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 862719005697 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 862719005698 active site 862719005699 homotetramer interface [polypeptide binding]; other site 862719005700 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719005701 TIGR02300 family protein; Region: FYDLN_acid 862719005702 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 862719005703 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 862719005704 hinge; other site 862719005705 active site 862719005706 cytidylate kinase; Provisional; Region: cmk; PRK00023 862719005707 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 862719005708 CMP-binding site; other site 862719005709 The sites determining sugar specificity; other site 862719005710 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 862719005711 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 862719005712 RNA binding site [nucleotide binding]; other site 862719005713 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 862719005714 RNA binding site [nucleotide binding]; other site 862719005715 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 862719005716 RNA binding site [nucleotide binding]; other site 862719005717 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 862719005718 RNA binding site [nucleotide binding]; other site 862719005719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862719005720 RNA binding site [nucleotide binding]; other site 862719005721 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 862719005722 RNA binding site [nucleotide binding]; other site 862719005723 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 862719005724 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 862719005725 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 862719005726 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 862719005727 Transcriptional regulator; Region: Transcrip_reg; cl00361 862719005728 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 862719005729 active site 862719005730 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 862719005731 TSCPD domain; Region: TSCPD; cl14834 862719005732 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 862719005733 GAF domain; Region: GAF_2; pfam13185 862719005734 GAF domain; Region: GAF; cl15785 862719005735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005736 metal binding site [ion binding]; metal-binding site 862719005737 active site 862719005738 I-site; other site 862719005739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719005740 pyruvate phosphate dikinase; Provisional; Region: PRK09279 862719005741 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862719005742 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719005743 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719005744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719005745 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719005746 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719005747 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719005748 Predicted transcriptional regulator [Transcription]; Region: COG4190 862719005749 Helix-turn-helix domains; Region: HTH; cl00088 862719005750 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 862719005751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719005752 ATP binding site [chemical binding]; other site 862719005753 putative Mg++ binding site [ion binding]; other site 862719005754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719005755 nucleotide binding region [chemical binding]; other site 862719005756 ATP-binding site [chemical binding]; other site 862719005757 Helicase associated domain (HA2); Region: HA2; cl04503 862719005758 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 862719005759 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 862719005760 diiron binding motif [ion binding]; other site 862719005761 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005763 active site 862719005764 phosphorylation site [posttranslational modification] 862719005765 intermolecular recognition site; other site 862719005766 dimerization interface [polypeptide binding]; other site 862719005767 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719005768 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719005769 anti sigma factor interaction site; other site 862719005770 regulatory phosphorylation site [posttranslational modification]; other site 862719005771 HRDC domain; Region: HRDC; cl02578 862719005772 formyl-coenzyme A transferase; Provisional; Region: PRK05398 862719005773 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719005774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005775 PAS domain; Region: PAS_9; pfam13426 862719005776 putative active site [active] 862719005777 heme pocket [chemical binding]; other site 862719005778 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 862719005779 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719005780 E3 interaction surface; other site 862719005781 lipoyl attachment site [posttranslational modification]; other site 862719005782 e3 binding domain; Region: E3_binding; pfam02817 862719005783 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 862719005784 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 862719005785 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 862719005786 TPP-binding site [chemical binding]; other site 862719005787 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 862719005788 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 862719005789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005790 CoA-ligase; Region: Ligase_CoA; cl02894 862719005791 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 862719005792 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 862719005793 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719005794 CoA-ligase; Region: Ligase_CoA; cl02894 862719005795 malate dehydrogenase; Reviewed; Region: PRK06223 862719005796 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 862719005797 NAD(P) binding site [chemical binding]; other site 862719005798 dimer interface [polypeptide binding]; other site 862719005799 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862719005800 substrate binding site [chemical binding]; other site 862719005801 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 862719005802 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 862719005803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719005804 active site 862719005805 nucleotide binding site [chemical binding]; other site 862719005806 HIGH motif; other site 862719005807 KMSKS motif; other site 862719005808 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 862719005809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719005810 dimerization interface [polypeptide binding]; other site 862719005811 putative DNA binding site [nucleotide binding]; other site 862719005812 putative Zn2+ binding site [ion binding]; other site 862719005813 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 862719005814 putative hydrophobic ligand binding site [chemical binding]; other site 862719005815 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719005816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719005817 substrate binding pocket [chemical binding]; other site 862719005818 membrane-bound complex binding site; other site 862719005819 hinge residues; other site 862719005820 PAS domain S-box; Region: sensory_box; TIGR00229 862719005821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719005822 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719005823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005824 metal binding site [ion binding]; metal-binding site 862719005825 active site 862719005826 I-site; other site 862719005827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719005828 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 862719005829 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 862719005830 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 862719005831 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 862719005832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719005833 nucleotide binding region [chemical binding]; other site 862719005834 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 862719005835 SEC-C motif; Region: SEC-C; pfam02810 862719005836 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 862719005837 PPIC-type PPIASE domain; Region: Rotamase; cl08278 862719005838 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 862719005839 heterotetramer interface [polypeptide binding]; other site 862719005840 active site pocket [active] 862719005841 cleavage site 862719005842 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 862719005843 active site 862719005844 8-oxo-dGMP binding site [chemical binding]; other site 862719005845 nudix motif; other site 862719005846 metal binding site [ion binding]; metal-binding site 862719005847 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 862719005848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719005849 ATP binding site [chemical binding]; other site 862719005850 putative Mg++ binding site [ion binding]; other site 862719005851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719005852 nucleotide binding region [chemical binding]; other site 862719005853 ATP-binding site [chemical binding]; other site 862719005854 RQC domain; Region: RQC; cl09632 862719005855 HRDC domain; Region: HRDC; cl02578 862719005856 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719005857 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862719005858 active site 862719005859 Sugar fermentation stimulation protein; Region: SfsA; cl00647 862719005860 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 862719005861 putative MPT binding site; other site 862719005862 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719005863 active site residue [active] 862719005864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719005865 dimerization interface [polypeptide binding]; other site 862719005866 putative DNA binding site [nucleotide binding]; other site 862719005867 putative Zn2+ binding site [ion binding]; other site 862719005868 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 862719005869 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 862719005870 diiron binding motif [ion binding]; other site 862719005871 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 862719005872 malate synthase A; Region: malate_syn_A; TIGR01344 862719005873 active site 862719005874 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 862719005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719005876 Walker A motif; other site 862719005877 ATP binding site [chemical binding]; other site 862719005878 Walker B motif; other site 862719005879 arginine finger; other site 862719005880 Helix-turn-helix domains; Region: HTH; cl00088 862719005881 phage shock protein A; Region: phageshock_pspA; TIGR02977 862719005882 Phage shock protein B; Region: PspB; cl05946 862719005883 phage shock protein C; Region: phageshock_pspC; TIGR02978 862719005884 PspC domain; Region: PspC; cl00864 862719005885 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 862719005886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719005887 MAPEG family; Region: MAPEG; cl09190 862719005888 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719005889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719005890 active site 862719005891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719005892 Right handed beta helix region; Region: Beta_helix; pfam13229 862719005893 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 862719005894 HemY protein N-terminus; Region: HemY_N; pfam07219 862719005895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719005896 TPR motif; other site 862719005897 binding surface 862719005898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719005899 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 862719005900 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 862719005901 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 862719005902 active site 862719005903 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 862719005904 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 862719005905 domain interfaces; other site 862719005906 active site 862719005907 UGMP family protein; Validated; Region: PRK09604 862719005908 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 862719005909 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 862719005910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005911 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 862719005912 LytTr DNA-binding domain; Region: LytTR; cl04498 862719005913 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 862719005914 Helix-turn-helix domains; Region: HTH; cl00088 862719005915 WYL domain; Region: WYL; cl14852 862719005916 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 862719005917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719005918 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 862719005919 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 862719005920 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 862719005921 generic binding surface I; other site 862719005922 generic binding surface II; other site 862719005923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005925 metal binding site [ion binding]; metal-binding site 862719005926 active site 862719005927 I-site; other site 862719005928 potassium uptake protein; Region: kup; TIGR00794 862719005929 K+ potassium transporter; Region: K_trans; cl15781 862719005930 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719005931 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 862719005932 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 862719005933 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 862719005934 dimerization interface [polypeptide binding]; other site 862719005935 domain crossover interface; other site 862719005936 redox-dependent activation switch; other site 862719005937 ornithine carbamoyltransferase; Provisional; Region: PRK00779 862719005938 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862719005939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005940 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 862719005941 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719005942 inhibitor-cofactor binding pocket; inhibition site 862719005943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719005944 catalytic residue [active] 862719005945 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719005946 RecX family; Region: RecX; cl00936 862719005947 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 862719005948 membrane ATPase/protein kinase; Provisional; Region: PRK09435 862719005949 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 862719005950 Walker A; other site 862719005951 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 862719005952 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719005953 Walker A/P-loop; other site 862719005954 ATP binding site [chemical binding]; other site 862719005955 Q-loop/lid; other site 862719005956 ABC transporter signature motif; other site 862719005957 Walker B; other site 862719005958 D-loop; other site 862719005959 H-loop/switch region; other site 862719005960 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719005961 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719005962 Walker A/P-loop; other site 862719005963 ATP binding site [chemical binding]; other site 862719005964 Q-loop/lid; other site 862719005965 ABC transporter signature motif; other site 862719005966 Walker B; other site 862719005967 D-loop; other site 862719005968 H-loop/switch region; other site 862719005969 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 862719005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005971 dimer interface [polypeptide binding]; other site 862719005972 conserved gate region; other site 862719005973 ABC-ATPase subunit interface; other site 862719005974 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 862719005975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005976 dimer interface [polypeptide binding]; other site 862719005977 conserved gate region; other site 862719005978 putative PBP binding loops; other site 862719005979 ABC-ATPase subunit interface; other site 862719005980 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719005981 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719005982 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719005983 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719005984 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 862719005985 active site 862719005986 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 862719005987 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 862719005988 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 862719005989 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 862719005990 putative NADH binding site [chemical binding]; other site 862719005991 putative active site [active] 862719005992 nudix motif; other site 862719005993 putative metal binding site [ion binding]; other site 862719005994 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719005995 prephenate dehydratase; Provisional; Region: PRK11899 862719005996 Prephenate dehydratase; Region: PDT; pfam00800 862719005997 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 862719005998 putative L-Phe binding site [chemical binding]; other site 862719005999 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 862719006000 Ligand binding site; other site 862719006001 oligomer interface; other site 862719006002 Cytochrome c; Region: Cytochrom_C; cl11414 862719006003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 862719006004 nudix motif; other site 862719006005 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006007 active site 862719006008 phosphorylation site [posttranslational modification] 862719006009 intermolecular recognition site; other site 862719006010 dimerization interface [polypeptide binding]; other site 862719006011 PrkA family serine protein kinase; Provisional; Region: PRK15455 862719006012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719006013 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 862719006014 Uncharacterized conserved protein [Function unknown]; Region: COG2718 862719006015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862719006016 SpoVR family protein; Provisional; Region: PRK11767 862719006017 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 862719006018 PilZ domain; Region: PilZ; cl01260 862719006019 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719006020 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 862719006021 AMP-binding enzyme; Region: AMP-binding; cl15778 862719006022 Acylphosphatase; Region: Acylphosphatase; cl00551 862719006023 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 862719006024 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719006025 anti sigma factor interaction site; other site 862719006026 regulatory phosphorylation site [posttranslational modification]; other site 862719006027 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 862719006028 MgtE intracellular N domain; Region: MgtE_N; cl15244 862719006029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 862719006030 Divalent cation transporter; Region: MgtE; cl00786 862719006031 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719006032 CoenzymeA binding site [chemical binding]; other site 862719006033 subunit interaction site [polypeptide binding]; other site 862719006034 PHB binding site; other site 862719006035 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 862719006036 ThiS interaction site; other site 862719006037 putative active site [active] 862719006038 tetramer interface [polypeptide binding]; other site 862719006039 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 862719006040 thiS-thiF/thiG interaction site; other site 862719006041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006042 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 862719006043 FIST N domain; Region: FIST; cl10701 862719006044 FIST C domain; Region: FIST_C; pfam10442 862719006045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006046 dimer interface [polypeptide binding]; other site 862719006047 putative CheW interface [polypeptide binding]; other site 862719006048 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 862719006049 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862719006050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006051 active site 862719006052 dimerization interface [polypeptide binding]; other site 862719006053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719006054 DNA binding site [nucleotide binding] 862719006055 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 862719006056 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 862719006057 putative catalytic residue [active] 862719006058 voltage-gated potassium channel; Provisional; Region: PRK10537 862719006059 Ion channel; Region: Ion_trans_2; cl11596 862719006060 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 862719006061 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719006062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719006063 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862719006064 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862719006065 active site 862719006066 HIGH motif; other site 862719006067 dimer interface [polypeptide binding]; other site 862719006068 KMSKS motif; other site 862719006069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 862719006070 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719006071 DNA repair protein radc; Region: radc; TIGR00608 862719006072 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 862719006073 MPN+ (JAMM) motif; other site 862719006074 Zinc-binding site [ion binding]; other site 862719006075 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862719006076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006077 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 862719006078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719006079 NMT1-like family; Region: NMT1_2; cl15260 862719006080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719006081 NMT1-like family; Region: NMT1_2; cl15260 862719006082 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 862719006083 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 862719006084 FAD binding domain; Region: FAD_binding_4; pfam01565 862719006085 FAD binding domain; Region: FAD_binding_4; pfam01565 862719006086 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 862719006087 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 862719006088 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 862719006089 Cysteine-rich domain; Region: CCG; pfam02754 862719006090 Cysteine-rich domain; Region: CCG; pfam02754 862719006091 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 862719006092 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719006093 Protein of unknown function DUF72; Region: DUF72; cl00777 862719006094 Predicted membrane protein [Function unknown]; Region: COG5373 862719006095 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 862719006096 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 862719006097 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 862719006098 active site 862719006099 NAD binding site [chemical binding]; other site 862719006100 metal binding site [ion binding]; metal-binding site 862719006101 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719006102 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719006103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719006104 active site 862719006105 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719006106 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719006107 catalytic residue [active] 862719006108 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 862719006109 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 862719006110 putative dimer interface [polypeptide binding]; other site 862719006111 active site pocket [active] 862719006112 putative cataytic base [active] 862719006113 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 862719006114 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 862719006115 metal binding site [ion binding]; metal-binding site 862719006116 dimer interface [polypeptide binding]; other site 862719006117 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 862719006118 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 862719006119 trimer interface [polypeptide binding]; other site 862719006120 active site 862719006121 substrate binding site [chemical binding]; other site 862719006122 CoA binding site [chemical binding]; other site 862719006123 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 862719006124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719006125 motif II; other site 862719006126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719006127 PAS domain; Region: PAS_9; pfam13426 862719006128 putative active site [active] 862719006129 heme pocket [chemical binding]; other site 862719006130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719006131 metal binding site [ion binding]; metal-binding site 862719006132 active site 862719006133 I-site; other site 862719006134 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 862719006135 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719006136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719006137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719006138 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719006139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719006140 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719006141 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719006142 signal recognition particle protein; Provisional; Region: PRK10867 862719006143 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 862719006144 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 862719006145 P loop; other site 862719006146 GTP binding site [chemical binding]; other site 862719006147 Signal peptide binding domain; Region: SRP_SPB; pfam02978 862719006148 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 862719006149 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 862719006150 RimM N-terminal domain; Region: RimM; pfam01782 862719006151 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 862719006152 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 862719006153 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 862719006154 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 862719006155 Ribonuclease P; Region: Ribonuclease_P; cl00457 862719006156 Haemolytic domain; Region: Haemolytic; cl00506 862719006157 membrane protein insertase; Provisional; Region: PRK01318 862719006158 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 862719006159 Predicted GTPase [General function prediction only]; Region: COG0218 862719006160 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 862719006161 G1 box; other site 862719006162 GTP/Mg2+ binding site [chemical binding]; other site 862719006163 Switch I region; other site 862719006164 G2 box; other site 862719006165 G3 box; other site 862719006166 Switch II region; other site 862719006167 G4 box; other site 862719006168 G5 box; other site 862719006169 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862719006170 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 862719006171 feedback inhibition sensing region; other site 862719006172 homohexameric interface [polypeptide binding]; other site 862719006173 nucleotide binding site [chemical binding]; other site 862719006174 N-acetyl-L-glutamate binding site [chemical binding]; other site 862719006175 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 862719006176 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 862719006177 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 862719006178 ThiC-associated domain; Region: ThiC-associated; pfam13667 862719006179 ThiC family; Region: ThiC; cl08031 862719006180 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 862719006181 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862719006182 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719006183 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 862719006184 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 862719006185 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862719006186 AMIN domain; Region: AMIN; pfam11741 862719006187 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 862719006188 active site 862719006189 metal binding site [ion binding]; metal-binding site 862719006190 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 862719006191 Transglycosylase; Region: Transgly; cl07896 862719006192 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719006193 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862719006194 catalytic triad [active] 862719006195 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 862719006196 peptide chain release factor 2; Provisional; Region: PRK07342 862719006197 RF-1 domain; Region: RF-1; cl02875 862719006198 RF-1 domain; Region: RF-1; cl02875 862719006199 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719006200 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719006201 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 862719006202 fructokinase; Reviewed; Region: PRK09557 862719006203 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862719006204 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719006205 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719006206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719006207 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 862719006208 EBNA-3B; Provisional; Region: PHA03378 862719006209 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 862719006210 MORN repeat; Region: MORN; cl14787 862719006211 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 862719006212 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719006213 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719006214 Walker A/P-loop; other site 862719006215 ATP binding site [chemical binding]; other site 862719006216 Q-loop/lid; other site 862719006217 ABC transporter signature motif; other site 862719006218 Walker B; other site 862719006219 D-loop; other site 862719006220 H-loop/switch region; other site 862719006221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719006222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719006223 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719006224 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719006225 Walker A/P-loop; other site 862719006226 ATP binding site [chemical binding]; other site 862719006227 Q-loop/lid; other site 862719006228 ABC transporter signature motif; other site 862719006229 Walker B; other site 862719006230 D-loop; other site 862719006231 H-loop/switch region; other site 862719006232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719006233 dimer interface [polypeptide binding]; other site 862719006234 conserved gate region; other site 862719006235 ABC-ATPase subunit interface; other site 862719006236 NMT1-like family; Region: NMT1_2; cl15260 862719006237 NMT1/THI5 like; Region: NMT1; pfam09084 862719006238 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719006239 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719006240 Walker A/P-loop; other site 862719006241 ATP binding site [chemical binding]; other site 862719006242 Q-loop/lid; other site 862719006243 ABC transporter signature motif; other site 862719006244 Walker B; other site 862719006245 D-loop; other site 862719006246 H-loop/switch region; other site 862719006247 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719006248 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719006249 Walker A/P-loop; other site 862719006250 ATP binding site [chemical binding]; other site 862719006251 Q-loop/lid; other site 862719006252 ABC transporter signature motif; other site 862719006253 Walker B; other site 862719006254 D-loop; other site 862719006255 H-loop/switch region; other site 862719006256 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719006257 TM-ABC transporter signature motif; other site 862719006258 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719006259 TM-ABC transporter signature motif; other site 862719006260 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719006261 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 862719006262 putative ligand binding site [chemical binding]; other site 862719006263 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719006264 Helix-turn-helix domains; Region: HTH; cl00088 862719006265 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 862719006266 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 862719006267 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 862719006268 SLBB domain; Region: SLBB; pfam10531 862719006269 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719006270 catalytic residues [active] 862719006271 catalytic nucleophile [active] 862719006272 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719006273 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719006274 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719006275 Synaptic Site I dimer interface [polypeptide binding]; other site 862719006276 DNA binding site [nucleotide binding] 862719006277 Recombinase; Region: Recombinase; pfam07508 862719006278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719006279 active site 862719006280 Int/Topo IB signature motif; other site 862719006281 DNA binding site [nucleotide binding] 862719006282 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719006283 Transposase domain (DUF772); Region: DUF772; cl15789 862719006284 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862719006285 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 862719006286 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719006287 elongation factor Tu; Reviewed; Region: PRK00049 862719006288 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862719006289 G1 box; other site 862719006290 GEF interaction site [polypeptide binding]; other site 862719006291 GTP/Mg2+ binding site [chemical binding]; other site 862719006292 Switch I region; other site 862719006293 G2 box; other site 862719006294 G3 box; other site 862719006295 Switch II region; other site 862719006296 G4 box; other site 862719006297 G5 box; other site 862719006298 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862719006299 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862719006300 Antibiotic Binding Site [chemical binding]; other site 862719006301 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 862719006302 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 862719006303 putative homodimer interface [polypeptide binding]; other site 862719006304 KOW motif; Region: KOW; cl00354 862719006305 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 862719006306 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 862719006307 23S rRNA interface [nucleotide binding]; other site 862719006308 L7/L12 interface [polypeptide binding]; other site 862719006309 putative thiostrepton binding site; other site 862719006310 L25 interface [polypeptide binding]; other site 862719006311 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 862719006312 mRNA/rRNA interface [nucleotide binding]; other site 862719006313 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 862719006314 23S rRNA interface [nucleotide binding]; other site 862719006315 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 862719006316 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 862719006317 L11 interface [polypeptide binding]; other site 862719006318 putative EF-Tu interaction site [polypeptide binding]; other site 862719006319 putative EF-G interaction site [polypeptide binding]; other site 862719006320 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 862719006321 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 862719006322 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 862719006323 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862719006324 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 862719006325 RPB11 interaction site [polypeptide binding]; other site 862719006326 RPB12 interaction site [polypeptide binding]; other site 862719006327 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862719006328 RPB1 interaction site [polypeptide binding]; other site 862719006329 RPB11 interaction site [polypeptide binding]; other site 862719006330 RPB10 interaction site [polypeptide binding]; other site 862719006331 RPB3 interaction site [polypeptide binding]; other site 862719006332 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 862719006333 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 862719006334 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 862719006335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 862719006336 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 862719006337 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 862719006338 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719006339 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 862719006340 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 862719006341 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719006342 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 862719006343 DNA binding site [nucleotide binding] 862719006344 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 862719006345 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 862719006346 S17 interaction site [polypeptide binding]; other site 862719006347 S8 interaction site; other site 862719006348 16S rRNA interaction site [nucleotide binding]; other site 862719006349 streptomycin interaction site [chemical binding]; other site 862719006350 23S rRNA interaction site [nucleotide binding]; other site 862719006351 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 862719006352 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 862719006353 elongation factor G; Reviewed; Region: PRK00007 862719006354 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862719006355 G1 box; other site 862719006356 putative GEF interaction site [polypeptide binding]; other site 862719006357 GTP/Mg2+ binding site [chemical binding]; other site 862719006358 Switch I region; other site 862719006359 G2 box; other site 862719006360 G3 box; other site 862719006361 Switch II region; other site 862719006362 G4 box; other site 862719006363 G5 box; other site 862719006364 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719006365 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862719006366 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719006367 elongation factor Tu; Reviewed; Region: PRK00049 862719006368 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862719006369 G1 box; other site 862719006370 GEF interaction site [polypeptide binding]; other site 862719006371 GTP/Mg2+ binding site [chemical binding]; other site 862719006372 Switch I region; other site 862719006373 G2 box; other site 862719006374 G3 box; other site 862719006375 Switch II region; other site 862719006376 G4 box; other site 862719006377 G5 box; other site 862719006378 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862719006379 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862719006380 Antibiotic Binding Site [chemical binding]; other site 862719006381 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 862719006382 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 862719006383 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 862719006384 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 862719006385 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 862719006386 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 862719006387 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 862719006388 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 862719006389 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 862719006390 putative translocon binding site; other site 862719006391 protein-rRNA interface [nucleotide binding]; other site 862719006392 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 862719006393 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 862719006394 G-X-X-G motif; other site 862719006395 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 862719006396 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 862719006397 23S rRNA interface [nucleotide binding]; other site 862719006398 5S rRNA interface [nucleotide binding]; other site 862719006399 putative antibiotic binding site [chemical binding]; other site 862719006400 L25 interface [polypeptide binding]; other site 862719006401 L27 interface [polypeptide binding]; other site 862719006402 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 862719006403 putative translocon interaction site; other site 862719006404 23S rRNA interface [nucleotide binding]; other site 862719006405 signal recognition particle (SRP54) interaction site; other site 862719006406 L23 interface [polypeptide binding]; other site 862719006407 trigger factor interaction site; other site 862719006408 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 862719006409 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 862719006410 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 862719006411 KOW motif; Region: KOW; cl00354 862719006412 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 862719006413 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 862719006414 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 862719006415 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 862719006416 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 862719006417 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 862719006418 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862719006419 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862719006420 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 862719006421 23S rRNA interface [nucleotide binding]; other site 862719006422 L21e interface [polypeptide binding]; other site 862719006423 5S rRNA interface [nucleotide binding]; other site 862719006424 L27 interface [polypeptide binding]; other site 862719006425 L5 interface [polypeptide binding]; other site 862719006426 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 862719006427 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 862719006428 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 862719006429 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 862719006430 23S rRNA binding site [nucleotide binding]; other site 862719006431 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 862719006432 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 862719006433 SecY translocase; Region: SecY; pfam00344 862719006434 adenylate kinase; Reviewed; Region: adk; PRK00279 862719006435 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 862719006436 AMP-binding site [chemical binding]; other site 862719006437 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 862719006438 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719006439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719006440 DNA-binding site [nucleotide binding]; DNA binding site 862719006441 FCD domain; Region: FCD; cl11656 862719006442 EamA-like transporter family; Region: EamA; cl01037 862719006443 Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; Region: CHROMO; cl15261 862719006444 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719006445 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 862719006446 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 862719006447 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 862719006448 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719006449 homodimer interface [polypeptide binding]; other site 862719006450 substrate-cofactor binding pocket; other site 862719006451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719006452 catalytic residue [active] 862719006453 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719006454 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719006455 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719006456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006457 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719006458 putative active site [active] 862719006459 heme pocket [chemical binding]; other site 862719006460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006461 putative active site [active] 862719006462 heme pocket [chemical binding]; other site 862719006463 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719006464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719006465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006466 dimer interface [polypeptide binding]; other site 862719006467 phosphorylation site [posttranslational modification] 862719006468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006469 ATP binding site [chemical binding]; other site 862719006470 Mg2+ binding site [ion binding]; other site 862719006471 G-X-G motif; other site 862719006472 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 862719006473 Ligand Binding Site [chemical binding]; other site 862719006474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719006475 NMT1-like family; Region: NMT1_2; cl15260 862719006476 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 862719006477 Cupin domain; Region: Cupin_2; cl09118 862719006478 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 862719006479 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719006480 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 862719006481 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 862719006482 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 862719006483 dimer interface [polypeptide binding]; other site 862719006484 active site 862719006485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719006486 catalytic residues [active] 862719006487 substrate binding site [chemical binding]; other site 862719006488 MgtC family; Region: MgtC; pfam02308 862719006489 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 862719006490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719006491 putative substrate translocation pore; other site 862719006492 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 862719006493 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 862719006494 active site 862719006495 Riboflavin kinase; Region: Flavokinase; cl03312 862719006496 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719006497 dimer interaction site [polypeptide binding]; other site 862719006498 substrate-binding tunnel; other site 862719006499 active site 862719006500 catalytic site [active] 862719006501 substrate binding site [chemical binding]; other site 862719006502 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 862719006503 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862719006504 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719006505 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719006506 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719006507 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 862719006508 CreA protein; Region: CreA; pfam05981 862719006509 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862719006510 active site 862719006511 Zn binding site [ion binding]; other site 862719006512 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719006513 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 862719006514 NRDE protein; Region: NRDE; cl01315 862719006515 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 862719006516 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 862719006517 ATP binding site [chemical binding]; other site 862719006518 active site 862719006519 substrate binding site [chemical binding]; other site 862719006520 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 862719006521 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719006522 endonuclease III; Region: ENDO3c; smart00478 862719006523 minor groove reading motif; other site 862719006524 helix-hairpin-helix signature motif; other site 862719006525 substrate binding pocket [chemical binding]; other site 862719006526 active site 862719006527 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 862719006528 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 862719006529 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 862719006530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719006531 putative active site [active] 862719006532 putative metal binding site [ion binding]; other site 862719006533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719006534 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 862719006535 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 862719006536 LysE type translocator; Region: LysE; cl00565 862719006537 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719006538 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 862719006539 putative active site [active] 862719006540 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 862719006541 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 862719006542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006543 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 862719006544 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 862719006545 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 862719006546 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 862719006547 putative acyl-acceptor binding pocket; other site 862719006548 LysE type translocator; Region: LysE; cl00565 862719006549 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 862719006550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719006551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006552 active site 862719006553 phosphorylation site [posttranslational modification] 862719006554 intermolecular recognition site; other site 862719006555 dimerization interface [polypeptide binding]; other site 862719006556 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719006557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006558 dimer interface [polypeptide binding]; other site 862719006559 phosphorylation site [posttranslational modification] 862719006560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006561 ATP binding site [chemical binding]; other site 862719006562 Mg2+ binding site [ion binding]; other site 862719006563 G-X-G motif; other site 862719006564 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006566 active site 862719006567 phosphorylation site [posttranslational modification] 862719006568 intermolecular recognition site; other site 862719006569 dimerization interface [polypeptide binding]; other site 862719006570 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719006571 Ligand binding site [chemical binding]; other site 862719006572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719006573 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719006574 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719006575 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719006576 oxidoreductase; Provisional; Region: PRK10015 862719006577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006578 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 862719006579 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006581 active site 862719006582 phosphorylation site [posttranslational modification] 862719006583 intermolecular recognition site; other site 862719006584 dimerization interface [polypeptide binding]; other site 862719006585 Nitrogen fixation protein NifW; Region: NifW; cl03935 862719006586 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 862719006587 serine O-acetyltransferase; Region: cysE; TIGR01172 862719006588 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719006589 trimer interface [polypeptide binding]; other site 862719006590 active site 862719006591 substrate binding site [chemical binding]; other site 862719006592 CoA binding site [chemical binding]; other site 862719006593 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 862719006594 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 862719006595 active site 862719006596 catalytic residues [active] 862719006597 metal binding site [ion binding]; metal-binding site 862719006598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719006599 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 862719006600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719006601 catalytic residue [active] 862719006602 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 862719006603 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 862719006604 trimerization site [polypeptide binding]; other site 862719006605 active site 862719006606 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719006607 NifU-like domain; Region: NifU; cl00484 862719006608 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 862719006609 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 862719006610 FMN binding site [chemical binding]; other site 862719006611 active site 862719006612 substrate binding site [chemical binding]; other site 862719006613 catalytic residue [active] 862719006614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719006615 Helix-turn-helix domains; Region: HTH; cl00088 862719006616 Predicted permeases [General function prediction only]; Region: RarD; COG2962 862719006617 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 862719006618 putative GSH binding site [chemical binding]; other site 862719006619 catalytic residues [active] 862719006620 BolA-like protein; Region: BolA; cl00386 862719006621 adenylosuccinate lyase; Provisional; Region: PRK07492 862719006622 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 862719006623 tetramer interface [polypeptide binding]; other site 862719006624 active site 862719006625 Cache domain; Region: Cache_2; cl07034 862719006626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 862719006627 Cache domain; Region: Cache_2; cl07034 862719006628 PAS domain S-box; Region: sensory_box; TIGR00229 862719006629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006630 PAS domain; Region: PAS_9; pfam13426 862719006631 putative active site [active] 862719006632 heme pocket [chemical binding]; other site 862719006633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719006634 metal binding site [ion binding]; metal-binding site 862719006635 active site 862719006636 I-site; other site 862719006637 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719006638 Protein of unknown function DUF45; Region: DUF45; cl00636 862719006639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719006640 PAS fold; Region: PAS_4; pfam08448 862719006641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719006642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006643 ATP binding site [chemical binding]; other site 862719006644 Mg2+ binding site [ion binding]; other site 862719006645 G-X-G motif; other site 862719006646 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006648 active site 862719006649 phosphorylation site [posttranslational modification] 862719006650 intermolecular recognition site; other site 862719006651 dimerization interface [polypeptide binding]; other site 862719006652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 862719006653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719006654 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 862719006655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719006656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 862719006657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719006658 dimer interface [polypeptide binding]; other site 862719006659 conserved gate region; other site 862719006660 putative PBP binding loops; other site 862719006661 ABC-ATPase subunit interface; other site 862719006662 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 862719006663 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 862719006664 Walker A/P-loop; other site 862719006665 ATP binding site [chemical binding]; other site 862719006666 Q-loop/lid; other site 862719006667 ABC transporter signature motif; other site 862719006668 Walker B; other site 862719006669 D-loop; other site 862719006670 H-loop/switch region; other site 862719006671 TOBE domain; Region: TOBE_2; cl01440 862719006672 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 862719006673 Peptidase family M48; Region: Peptidase_M48; cl12018 862719006674 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 862719006675 CobD/Cbib protein; Region: CobD_Cbib; cl00561 862719006676 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719006677 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719006678 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 862719006679 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719006680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006681 active site 862719006682 phosphorylation site [posttranslational modification] 862719006683 intermolecular recognition site; other site 862719006684 dimerization interface [polypeptide binding]; other site 862719006685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006686 dimer interface [polypeptide binding]; other site 862719006687 phosphorylation site [posttranslational modification] 862719006688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006689 ATP binding site [chemical binding]; other site 862719006690 Mg2+ binding site [ion binding]; other site 862719006691 G-X-G motif; other site 862719006692 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006694 active site 862719006695 phosphorylation site [posttranslational modification] 862719006696 intermolecular recognition site; other site 862719006697 dimerization interface [polypeptide binding]; other site 862719006698 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719006699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719006700 dimerization interface [polypeptide binding]; other site 862719006701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006702 PAS fold; Region: PAS_3; pfam08447 862719006703 putative active site [active] 862719006704 heme pocket [chemical binding]; other site 862719006705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719006706 PAS fold; Region: PAS_7; pfam12860 862719006707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719006708 dimer interface [polypeptide binding]; other site 862719006709 phosphorylation site [posttranslational modification] 862719006710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006711 ATP binding site [chemical binding]; other site 862719006712 Mg2+ binding site [ion binding]; other site 862719006713 G-X-G motif; other site 862719006714 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719006715 anti sigma factor interaction site; other site 862719006716 regulatory phosphorylation site [posttranslational modification]; other site 862719006717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719006718 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006720 active site 862719006721 phosphorylation site [posttranslational modification] 862719006722 intermolecular recognition site; other site 862719006723 dimerization interface [polypeptide binding]; other site 862719006724 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719006725 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 862719006726 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 862719006727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719006728 Walker A motif; other site 862719006729 ATP binding site [chemical binding]; other site 862719006730 Walker B motif; other site 862719006731 arginine finger; other site 862719006732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719006733 Walker A motif; other site 862719006734 ATP binding site [chemical binding]; other site 862719006735 Walker B motif; other site 862719006736 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719006737 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 862719006738 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719006739 Transposase domain (DUF772); Region: DUF772; cl15789 862719006740 Phasin protein; Region: Phasin_2; cl11491 862719006741 Phasin protein; Region: Phasin_2; cl11491 862719006742 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 862719006743 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862719006744 active site 862719006745 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 862719006746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719006747 Sporulation related domain; Region: SPOR; cl10051 862719006748 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006750 active site 862719006751 phosphorylation site [posttranslational modification] 862719006752 intermolecular recognition site; other site 862719006753 dimerization interface [polypeptide binding]; other site 862719006754 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 862719006755 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719006756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006757 dimer interface [polypeptide binding]; other site 862719006758 phosphorylation site [posttranslational modification] 862719006759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006760 ATP binding site [chemical binding]; other site 862719006761 Mg2+ binding site [ion binding]; other site 862719006762 G-X-G motif; other site 862719006763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006764 dimer interface [polypeptide binding]; other site 862719006765 phosphorylation site [posttranslational modification] 862719006766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719006767 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006769 active site 862719006770 phosphorylation site [posttranslational modification] 862719006771 intermolecular recognition site; other site 862719006772 dimerization interface [polypeptide binding]; other site 862719006773 CHASE domain; Region: CHASE; cl01369 862719006774 PAS fold; Region: PAS_4; pfam08448 862719006775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719006776 putative active site [active] 862719006777 heme pocket [chemical binding]; other site 862719006778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719006779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006780 ATP binding site [chemical binding]; other site 862719006781 Mg2+ binding site [ion binding]; other site 862719006782 G-X-G motif; other site 862719006783 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 862719006784 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719006785 dimer interaction site [polypeptide binding]; other site 862719006786 substrate-binding tunnel; other site 862719006787 active site 862719006788 catalytic site [active] 862719006789 substrate binding site [chemical binding]; other site 862719006790 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862719006791 Acetokinase family; Region: Acetate_kinase; cl01029 862719006792 propionate/acetate kinase; Provisional; Region: PRK12379 862719006793 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719006794 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 862719006795 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 862719006796 active site 862719006797 dimer interface [polypeptide binding]; other site 862719006798 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 862719006799 dimer interface [polypeptide binding]; other site 862719006800 active site 862719006801 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719006802 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719006803 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719006804 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862719006805 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719006806 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 862719006807 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 862719006808 lipoprotein signal peptidase; Provisional; Region: PRK14787 862719006809 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 862719006810 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719006811 active site 862719006812 HIGH motif; other site 862719006813 nucleotide binding site [chemical binding]; other site 862719006814 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862719006815 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 862719006816 active site 862719006817 KMSKS motif; other site 862719006818 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 862719006819 tRNA binding surface [nucleotide binding]; other site 862719006820 anticodon binding site; other site 862719006821 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 862719006822 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 862719006823 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006825 TPR motif; other site 862719006826 binding surface 862719006827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006828 binding surface 862719006829 TPR motif; other site 862719006830 TPR repeat; Region: TPR_11; pfam13414 862719006831 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719006832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719006834 active site 862719006835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719006837 active site 862719006838 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719006839 octamerization interface [polypeptide binding]; other site 862719006840 diferric-oxygen binding site [ion binding]; other site 862719006841 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719006842 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719006843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719006844 dimerization interface [polypeptide binding]; other site 862719006845 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006846 dimer interface [polypeptide binding]; other site 862719006847 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719006848 putative CheW interface [polypeptide binding]; other site 862719006849 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 862719006850 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 862719006851 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719006852 flagellin; Reviewed; Region: PRK12688 862719006853 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 862719006854 homotrimer interaction site [polypeptide binding]; other site 862719006855 putative active site [active] 862719006856 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719006857 Protein of unknown function, DUF482; Region: DUF482; pfam04339 862719006858 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719006859 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719006860 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 862719006861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719006862 FeS/SAM binding site; other site 862719006863 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 862719006864 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 862719006865 4Fe-4S binding domain; Region: Fer4; cl02805 862719006866 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 862719006867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719006868 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719006869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719006870 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 862719006871 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 862719006872 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 862719006873 GTP binding site; other site 862719006874 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 862719006875 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 862719006876 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 862719006877 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 862719006878 [4Fe-4S] binding site [ion binding]; other site 862719006879 molybdopterin cofactor binding site; other site 862719006880 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719006881 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719006882 molybdopterin cofactor binding site; other site 862719006883 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 862719006884 4Fe-4S binding domain; Region: Fer4; cl02805 862719006885 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719006886 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 862719006887 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 862719006888 intersubunit interface [polypeptide binding]; other site 862719006889 active site 862719006890 Zn2+ binding site [ion binding]; other site 862719006891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006892 dimer interface [polypeptide binding]; other site 862719006893 phosphorylation site [posttranslational modification] 862719006894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006895 ATP binding site [chemical binding]; other site 862719006896 Mg2+ binding site [ion binding]; other site 862719006897 G-X-G motif; other site 862719006898 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 862719006899 putative active site [active] 862719006900 metal binding site [ion binding]; metal-binding site 862719006901 Plant ATP synthase F0; Region: YMF19; cl07975 862719006902 Plant ATP synthase F0; Region: YMF19; cl07975 862719006903 ATP synthase subunit C; Region: ATP-synt_C; cl00466 862719006904 ATP synthase A chain; Region: ATP-synt_A; cl00413 862719006905 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719006906 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 862719006907 Cu(I) binding site [ion binding]; other site 862719006908 Cache domain; Region: Cache_2; cl07034 862719006909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719006910 dimerization interface [polypeptide binding]; other site 862719006911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006912 dimer interface [polypeptide binding]; other site 862719006913 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719006914 putative CheW interface [polypeptide binding]; other site 862719006915 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719006916 octamerization interface [polypeptide binding]; other site 862719006917 diferric-oxygen binding site [ion binding]; other site 862719006918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719006919 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719006920 septum formation inhibitor; Reviewed; Region: minC; PRK00339 862719006921 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 862719006922 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 862719006923 cell division inhibitor MinD; Provisional; Region: PRK10818 862719006924 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 862719006925 Switch I; other site 862719006926 Switch II; other site 862719006927 Septum formation topological specificity factor MinE; Region: MinE; cl00538 862719006928 Family description; Region: VCBS; pfam13517 862719006929 Family description; Region: VCBS; pfam13517 862719006930 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 862719006931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006932 PAS fold; Region: PAS_3; pfam08447 862719006933 putative active site [active] 862719006934 heme pocket [chemical binding]; other site 862719006935 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719006936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006937 dimer interface [polypeptide binding]; other site 862719006938 putative CheW interface [polypeptide binding]; other site 862719006939 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006940 putative CheW interface [polypeptide binding]; other site 862719006941 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719006942 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 862719006943 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 862719006944 active site 862719006945 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 862719006946 aromatic arch; other site 862719006947 DCoH dimer interaction site [polypeptide binding]; other site 862719006948 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 862719006949 DCoH tetramer interaction site [polypeptide binding]; other site 862719006950 substrate binding site [chemical binding]; other site 862719006951 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 862719006952 active site 862719006953 Predicted methyltransferase [General function prediction only]; Region: COG3897 862719006954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006955 NlpC/P60 family; Region: NLPC_P60; cl11438 862719006956 UbiA prenyltransferase family; Region: UbiA; cl00337 862719006957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006958 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006959 active site 862719006960 phosphorylation site [posttranslational modification] 862719006961 intermolecular recognition site; other site 862719006962 dimerization interface [polypeptide binding]; other site 862719006963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 862719006964 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 862719006965 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 862719006966 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 862719006967 4Fe-4S binding domain; Region: Fer4; cl02805 862719006968 Rop-like; Region: Rop-like; cl02247 862719006969 Protein of unknown function, DUF269; Region: DUF269; cl03973 862719006970 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 862719006971 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 862719006972 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 862719006973 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 862719006974 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 862719006975 Cache domain; Region: Cache_1; pfam02743 862719006976 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719006977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719006978 dimerization interface [polypeptide binding]; other site 862719006979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006980 dimer interface [polypeptide binding]; other site 862719006981 putative CheW interface [polypeptide binding]; other site 862719006982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006983 PAS domain; Region: PAS_9; pfam13426 862719006984 putative active site [active] 862719006985 heme pocket [chemical binding]; other site 862719006986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006987 PAS domain; Region: PAS_9; pfam13426 862719006988 putative active site [active] 862719006989 heme pocket [chemical binding]; other site 862719006990 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006991 dimer interface [polypeptide binding]; other site 862719006992 putative CheW interface [polypeptide binding]; other site 862719006993 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 862719006994 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 862719006995 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 862719006996 MoFe protein beta/alpha subunit interactions; other site 862719006997 Beta subunit P cluster binding residues; other site 862719006998 MoFe protein beta subunit/Fe protein contacts; other site 862719006999 MoFe protein dimer/ dimer interactions; other site 862719007000 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 862719007001 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 862719007002 MoFe protein alpha/beta subunit interactions; other site 862719007003 Alpha subunit P cluster binding residues; other site 862719007004 FeMoco binding residues [chemical binding]; other site 862719007005 MoFe protein alpha subunit/Fe protein contacts; other site 862719007006 MoFe protein dimer/ dimer interactions; other site 862719007007 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 862719007008 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 862719007009 Nucleotide-binding sites [chemical binding]; other site 862719007010 Walker A motif; other site 862719007011 Switch I region of nucleotide binding site; other site 862719007012 Fe4S4 binding sites [ion binding]; other site 862719007013 Switch II region of nucleotide binding site; other site 862719007014 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 862719007015 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 862719007016 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 862719007017 ArsC family; Region: ArsC; pfam03960 862719007018 putative catalytic residues [active] 862719007019 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 862719007020 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 862719007021 putative active site [active] 862719007022 putative dimer interface [polypeptide binding]; other site 862719007023 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 862719007024 AMP nucleosidase; Provisional; Region: PRK08292 862719007025 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 862719007026 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862719007027 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 862719007028 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 862719007029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719007030 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 862719007031 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862719007032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719007033 FeS/SAM binding site; other site 862719007034 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 862719007035 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 862719007036 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 862719007037 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 862719007038 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 862719007039 GtrA-like protein; Region: GtrA; cl00971 862719007040 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 862719007041 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719007042 Ligand binding site; other site 862719007043 Putative Catalytic site; other site 862719007044 DXD motif; other site 862719007045 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 862719007046 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 862719007047 substrate binding site [chemical binding]; other site 862719007048 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 862719007049 tartrate dehydrogenase; Provisional; Region: PRK08194 862719007050 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007052 active site 862719007053 phosphorylation site [posttranslational modification] 862719007054 intermolecular recognition site; other site 862719007055 dimerization interface [polypeptide binding]; other site 862719007056 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 862719007057 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719007058 pyridoxamine kinase; Validated; Region: PRK05756 862719007059 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 862719007060 dimer interface [polypeptide binding]; other site 862719007061 pyridoxal binding site [chemical binding]; other site 862719007062 ATP binding site [chemical binding]; other site 862719007063 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719007064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719007065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007066 dimer interface [polypeptide binding]; other site 862719007067 phosphorylation site [posttranslational modification] 862719007068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007069 ATP binding site [chemical binding]; other site 862719007070 Mg2+ binding site [ion binding]; other site 862719007071 G-X-G motif; other site 862719007072 Predicted ATPase [General function prediction only]; Region: COG1485 862719007073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719007074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719007075 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007076 Helix-turn-helix domains; Region: HTH; cl00088 862719007077 Helix-turn-helix domains; Region: HTH; cl00088 862719007078 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719007079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719007080 ligand binding site [chemical binding]; other site 862719007081 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 862719007082 Tubulin like; Region: Tubulin_2; pfam13809 862719007083 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007084 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 862719007086 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719007087 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719007088 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719007089 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719007090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719007091 dimerization interface [polypeptide binding]; other site 862719007092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007093 dimer interface [polypeptide binding]; other site 862719007094 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719007095 putative CheW interface [polypeptide binding]; other site 862719007096 lipoyl synthase; Provisional; Region: PRK05481 862719007097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719007098 FeS/SAM binding site; other site 862719007099 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719007100 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 862719007101 putative NAD(P) binding site [chemical binding]; other site 862719007102 catalytic Zn binding site [ion binding]; other site 862719007103 acetoin reductases; Region: 23BDH; TIGR02415 862719007104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007105 NAD(P) binding site [chemical binding]; other site 862719007106 active site 862719007107 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 862719007108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719007109 E3 interaction surface; other site 862719007110 lipoyl attachment site [posttranslational modification]; other site 862719007111 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719007112 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719007113 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719007114 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719007115 alpha subunit interface [polypeptide binding]; other site 862719007116 TPP binding site [chemical binding]; other site 862719007117 heterodimer interface [polypeptide binding]; other site 862719007118 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719007119 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719007120 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719007121 tetramer interface [polypeptide binding]; other site 862719007122 TPP-binding site [chemical binding]; other site 862719007123 heterodimer interface [polypeptide binding]; other site 862719007124 phosphorylation loop region [posttranslational modification] 862719007125 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 862719007126 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 862719007127 FAD binding domain; Region: FAD_binding_4; pfam01565 862719007128 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 862719007129 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 862719007130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719007131 Walker A/P-loop; other site 862719007132 ATP binding site [chemical binding]; other site 862719007133 Q-loop/lid; other site 862719007134 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719007135 ABC transporter; Region: ABC_tran_2; pfam12848 862719007136 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719007137 Cupin domain; Region: Cupin_2; cl09118 862719007138 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 862719007139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007140 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719007141 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007142 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007144 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007145 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 862719007146 VacJ like lipoprotein; Region: VacJ; cl01073 862719007147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719007148 dimerization interface [polypeptide binding]; other site 862719007149 putative Zn2+ binding site [ion binding]; other site 862719007150 putative DNA binding site [nucleotide binding]; other site 862719007151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007152 S-adenosylmethionine binding site [chemical binding]; other site 862719007153 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 862719007154 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 862719007155 FAD binding site [chemical binding]; other site 862719007156 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719007157 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 862719007158 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 862719007159 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 862719007160 substrate binding pocket [chemical binding]; other site 862719007161 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 862719007162 B12 binding site [chemical binding]; other site 862719007163 cobalt ligand [ion binding]; other site 862719007164 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 862719007165 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719007166 active site 862719007167 NTP binding site [chemical binding]; other site 862719007168 metal binding triad [ion binding]; metal-binding site 862719007169 antibiotic binding site [chemical binding]; other site 862719007170 HEPN domain; Region: HEPN; cl00824 862719007171 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719007172 active site 862719007173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007174 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719007175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719007178 metal binding site [ion binding]; metal-binding site 862719007179 active site 862719007180 I-site; other site 862719007181 Nitronate monooxygenase; Region: NMO; pfam03060 862719007182 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719007183 FMN binding site [chemical binding]; other site 862719007184 substrate binding site [chemical binding]; other site 862719007185 putative catalytic residue [active] 862719007186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719007187 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 862719007188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719007189 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 862719007190 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 862719007191 CysD dimerization site [polypeptide binding]; other site 862719007192 G1 box; other site 862719007193 putative GEF interaction site [polypeptide binding]; other site 862719007194 GTP/Mg2+ binding site [chemical binding]; other site 862719007195 Switch I region; other site 862719007196 G2 box; other site 862719007197 G3 box; other site 862719007198 Switch II region; other site 862719007199 G4 box; other site 862719007200 G5 box; other site 862719007201 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 862719007202 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 862719007203 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 862719007204 ligand-binding site [chemical binding]; other site 862719007205 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 862719007206 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719007207 Active Sites [active] 862719007208 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719007209 Active Sites [active] 862719007210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007211 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 862719007212 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 862719007213 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719007214 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719007215 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 862719007216 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719007217 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719007218 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719007219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007220 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719007221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007223 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007224 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719007225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007226 dimer interface [polypeptide binding]; other site 862719007227 phosphorylation site [posttranslational modification] 862719007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007229 ATP binding site [chemical binding]; other site 862719007230 Mg2+ binding site [ion binding]; other site 862719007231 G-X-G motif; other site 862719007232 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719007233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007234 active site 862719007235 phosphorylation site [posttranslational modification] 862719007236 intermolecular recognition site; other site 862719007237 dimerization interface [polypeptide binding]; other site 862719007238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719007239 DNA binding residues [nucleotide binding] 862719007240 dimerization interface [polypeptide binding]; other site 862719007241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007242 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719007243 putative active site [active] 862719007244 heme pocket [chemical binding]; other site 862719007245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719007246 dimer interface [polypeptide binding]; other site 862719007247 phosphorylation site [posttranslational modification] 862719007248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007249 ATP binding site [chemical binding]; other site 862719007250 Mg2+ binding site [ion binding]; other site 862719007251 G-X-G motif; other site 862719007252 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719007253 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719007254 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719007255 DctM-like transporters; Region: DctM; pfam06808 862719007256 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719007257 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 862719007258 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 862719007259 putative [4Fe-4S] binding site [ion binding]; other site 862719007260 putative molybdopterin cofactor binding site [chemical binding]; other site 862719007261 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719007262 molybdopterin cofactor binding site; other site 862719007263 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 862719007264 DHH family; Region: DHH; pfam01368 862719007265 DHHA1 domain; Region: DHHA1; pfam02272 862719007266 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 862719007267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719007268 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 862719007269 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862719007270 FMN binding site [chemical binding]; other site 862719007271 active site 862719007272 catalytic residues [active] 862719007273 substrate binding site [chemical binding]; other site 862719007274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719007275 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719007276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007277 dimer interface [polypeptide binding]; other site 862719007278 putative CheW interface [polypeptide binding]; other site 862719007279 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 862719007280 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 862719007281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719007282 catalytic residue [active] 862719007283 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719007284 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862719007285 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719007286 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719007287 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719007288 hypothetical protein; Validated; Region: PRK09039 862719007289 hypothetical protein; Validated; Region: PRK09039 862719007290 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719007291 ligand binding site [chemical binding]; other site 862719007292 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 862719007293 active site 862719007294 dimerization interface [polypeptide binding]; other site 862719007295 elongation factor P; Validated; Region: PRK00529 862719007296 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 862719007297 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 862719007298 RNA binding site [nucleotide binding]; other site 862719007299 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 862719007300 RNA binding site [nucleotide binding]; other site 862719007301 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 862719007302 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 862719007303 motif 1; other site 862719007304 dimer interface [polypeptide binding]; other site 862719007305 active site 862719007306 motif 2; other site 862719007307 motif 3; other site 862719007308 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 862719007309 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 862719007310 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719007311 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 862719007312 thiamine phosphate binding site [chemical binding]; other site 862719007313 active site 862719007314 pyrophosphate binding site [ion binding]; other site 862719007315 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 862719007316 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 862719007317 putative active site; other site 862719007318 catalytic residue [active] 862719007319 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 862719007320 HicB family; Region: HicB; pfam05534 862719007321 Cache domain; Region: Cache_2; cl07034 862719007322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719007323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007324 dimer interface [polypeptide binding]; other site 862719007325 putative CheW interface [polypeptide binding]; other site 862719007326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007327 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 862719007328 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862719007329 transketolase; Reviewed; Region: PRK05899 862719007330 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719007331 TPP-binding site [chemical binding]; other site 862719007332 dimer interface [polypeptide binding]; other site 862719007333 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719007334 PYR/PP interface [polypeptide binding]; other site 862719007335 dimer interface [polypeptide binding]; other site 862719007336 TPP binding site [chemical binding]; other site 862719007337 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719007338 Cell division protein ZapA; Region: ZapA; cl01146 862719007339 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 862719007340 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 862719007341 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719007342 putative active site [active] 862719007343 metal binding site [ion binding]; metal-binding site 862719007344 homodimer binding site [polypeptide binding]; other site 862719007345 Transcriptional regulator; Region: Transcrip_reg; cl00361 862719007346 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 862719007347 active site 862719007348 putative DNA-binding cleft [nucleotide binding]; other site 862719007349 dimer interface [polypeptide binding]; other site 862719007350 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719007351 putative active site [active] 862719007352 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 862719007353 RuvA N terminal domain; Region: RuvA_N; pfam01330 862719007354 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 862719007355 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 862719007356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007357 Walker A motif; other site 862719007358 ATP binding site [chemical binding]; other site 862719007359 Walker B motif; other site 862719007360 arginine finger; other site 862719007361 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 862719007362 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719007363 active site 862719007364 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719007365 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 862719007366 translocation protein TolB; Provisional; Region: tolB; PRK05137 862719007367 TolB amino-terminal domain; Region: TolB_N; cl00639 862719007368 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719007369 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719007370 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719007371 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719007372 ligand binding site [chemical binding]; other site 862719007373 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 862719007374 Tetratricopeptide repeat; Region: TPR_6; pfam13174 862719007375 Tetratricopeptide repeat; Region: TPR_6; pfam13174 862719007376 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 862719007377 Ligand Binding Site [chemical binding]; other site 862719007378 FtsH Extracellular; Region: FtsH_ext; pfam06480 862719007379 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862719007380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007381 Walker A motif; other site 862719007382 ATP binding site [chemical binding]; other site 862719007383 Walker B motif; other site 862719007384 arginine finger; other site 862719007385 Peptidase family M41; Region: Peptidase_M41; pfam01434 862719007386 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 862719007387 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 862719007388 NAD binding site [chemical binding]; other site 862719007389 homotetramer interface [polypeptide binding]; other site 862719007390 homodimer interface [polypeptide binding]; other site 862719007391 substrate binding site [chemical binding]; other site 862719007392 active site 862719007393 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 862719007394 Protein of unknown function (DUF805); Region: DUF805; cl01224 862719007395 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 862719007396 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719007397 HSP70 interaction site [polypeptide binding]; other site 862719007398 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862719007399 substrate binding site [polypeptide binding]; other site 862719007400 dimer interface [polypeptide binding]; other site 862719007401 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719007402 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 862719007403 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719007404 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 862719007405 Cation efflux family; Region: Cation_efflux; cl00316 862719007406 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 862719007407 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719007408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007409 dimer interface [polypeptide binding]; other site 862719007410 putative CheW interface [polypeptide binding]; other site 862719007411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719007412 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719007413 transmembrane helices; other site 862719007414 GAF domain; Region: GAF_2; pfam13185 862719007415 GAF domain; Region: GAF; cl15785 862719007416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719007417 Zn2+ binding site [ion binding]; other site 862719007418 Mg2+ binding site [ion binding]; other site 862719007419 Hydrogenase formation hypA family; Region: HypD; cl12072 862719007420 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 862719007421 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719007422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719007423 Ligand Binding Site [chemical binding]; other site 862719007424 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719007425 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 862719007426 dimerization interface [polypeptide binding]; other site 862719007427 metal binding site [ion binding]; metal-binding site 862719007428 Predicted transcriptional regulator [Transcription]; Region: COG4957 862719007429 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719007430 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 862719007431 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862719007432 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862719007433 dimer interface [polypeptide binding]; other site 862719007434 active site 862719007435 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862719007436 folate binding site [chemical binding]; other site 862719007437 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 862719007438 ATP cone domain; Region: ATP-cone; pfam03477 862719007439 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 862719007440 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 862719007441 thiamine monophosphate kinase; Provisional; Region: PRK05731 862719007442 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 862719007443 ATP binding site [chemical binding]; other site 862719007444 dimerization interface [polypeptide binding]; other site 862719007445 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 862719007446 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 862719007447 homopentamer interface [polypeptide binding]; other site 862719007448 active site 862719007449 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 862719007450 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 862719007451 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 862719007452 dimerization interface [polypeptide binding]; other site 862719007453 active site 862719007454 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 862719007455 Lumazine binding domain; Region: Lum_binding; pfam00677 862719007456 Lumazine binding domain; Region: Lum_binding; pfam00677 862719007457 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 862719007458 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 862719007459 catalytic motif [active] 862719007460 Zn binding site [ion binding]; other site 862719007461 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 862719007462 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 862719007463 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 862719007464 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 862719007465 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 862719007466 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862719007467 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 862719007468 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719007469 dimer interface [polypeptide binding]; other site 862719007470 active site 862719007471 CoA binding pocket [chemical binding]; other site 862719007472 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719007473 IHF dimer interface [polypeptide binding]; other site 862719007474 IHF - DNA interface [nucleotide binding]; other site 862719007475 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 862719007476 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719007477 DNA binding residues [nucleotide binding] 862719007478 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 862719007479 Evidence 7 : Gene remnant; Product type e : enzyme 862719007480 Evidence 4 : Homologs of previously reported genes of unknown function; Product type e : enzyme 862719007481 Evidence 7 : Gene remnant; Product type e : enzyme 862719007482 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719007483 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719007484 catalytic residues [active] 862719007485 catalytic nucleophile [active] 862719007486 Recombinase; Region: Recombinase; pfam07508 862719007487 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719007488 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719007489 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007490 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 862719007491 Integrase core domain; Region: rve; cl01316 862719007492 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719007493 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007494 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 862719007495 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 862719007496 metal binding site [ion binding]; metal-binding site 862719007497 dimer interface [polypeptide binding]; other site 862719007498 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 862719007499 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 862719007500 metal binding site [ion binding]; metal-binding site 862719007501 putative dimer interface [polypeptide binding]; other site 862719007502 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862719007503 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719007504 Walker A/P-loop; other site 862719007505 ATP binding site [chemical binding]; other site 862719007506 Q-loop/lid; other site 862719007507 ABC transporter signature motif; other site 862719007508 Walker B; other site 862719007509 D-loop; other site 862719007510 H-loop/switch region; other site 862719007511 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719007512 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719007513 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719007514 Walker A/P-loop; other site 862719007515 ATP binding site [chemical binding]; other site 862719007516 Q-loop/lid; other site 862719007517 ABC transporter signature motif; other site 862719007518 Walker B; other site 862719007519 D-loop; other site 862719007520 H-loop/switch region; other site 862719007521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719007522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719007523 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862719007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719007525 dimer interface [polypeptide binding]; other site 862719007526 conserved gate region; other site 862719007527 putative PBP binding loops; other site 862719007528 ABC-ATPase subunit interface; other site 862719007529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719007530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719007531 dimer interface [polypeptide binding]; other site 862719007532 conserved gate region; other site 862719007533 putative PBP binding loops; other site 862719007534 ABC-ATPase subunit interface; other site 862719007535 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 862719007536 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719007537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719007538 Helix-turn-helix domains; Region: HTH; cl00088 862719007539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719007540 dimerization interface [polypeptide binding]; other site 862719007541 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719007542 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719007543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719007544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719007545 DNA binding residues [nucleotide binding] 862719007546 Uncharacterized conserved protein [Function unknown]; Region: COG3391 862719007547 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719007548 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719007549 Domain of unknown function (DUF305); Region: DUF305; cl15795 862719007550 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007551 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719007552 classical (c) SDRs; Region: SDR_c; cd05233 862719007553 NAD(P) binding site [chemical binding]; other site 862719007554 active site 862719007555 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 862719007556 putative catalytic residues [active] 862719007557 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 862719007558 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719007559 Helix-turn-helix domains; Region: HTH; cl00088 862719007560 transcriptional activator TtdR; Provisional; Region: PRK09801 862719007561 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719007562 putative effector binding pocket; other site 862719007563 dimerization interface [polypeptide binding]; other site 862719007564 Uncharacterized conserved protein [Function unknown]; Region: COG2128 862719007565 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719007566 classical (c) SDRs; Region: SDR_c; cd05233 862719007567 NAD(P) binding site [chemical binding]; other site 862719007568 active site 862719007569 Evidence 7 : Gene remnant; Product type e : enzyme 862719007570 OsmC-like protein; Region: OsmC; cl00767 862719007571 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719007572 Helix-turn-helix domains; Region: HTH; cl00088 862719007573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719007574 Coenzyme A binding pocket [chemical binding]; other site 862719007575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719007576 HemK family putative methylases; Region: hemK_fam; TIGR00536 862719007577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007578 S-adenosylmethionine binding site [chemical binding]; other site 862719007579 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 862719007580 ArsC family; Region: ArsC; pfam03960 862719007581 catalytic residues [active] 862719007582 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 862719007583 Uncharacterized protein conserved in archaea (DUF2112); Region: DUF2112; cl01669 862719007584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007585 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 862719007586 L-serine binding site [chemical binding]; other site 862719007587 ACT domain interface; other site 862719007588 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 862719007589 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719007590 EamA-like transporter family; Region: EamA; cl01037 862719007591 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 862719007592 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 862719007593 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 862719007594 catalytic site [active] 862719007595 subunit interface [polypeptide binding]; other site 862719007596 GatB domain; Region: GatB_Yqey; cl11497 862719007597 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719007598 putative active site [active] 862719007599 DNA primase; Validated; Region: dnaG; PRK05667 862719007600 CHC2 zinc finger; Region: zf-CHC2; cl15369 862719007601 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 862719007602 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 862719007603 active site 862719007604 metal binding site [ion binding]; metal-binding site 862719007605 interdomain interaction site; other site 862719007606 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 862719007607 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 862719007608 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 862719007609 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 862719007610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719007611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719007612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719007613 DNA binding residues [nucleotide binding] 862719007614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719007615 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719007616 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719007617 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719007618 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 862719007619 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 862719007620 Walker A/P-loop; other site 862719007621 ATP binding site [chemical binding]; other site 862719007622 Q-loop/lid; other site 862719007623 ABC transporter signature motif; other site 862719007624 Walker B; other site 862719007625 D-loop; other site 862719007626 H-loop/switch region; other site 862719007627 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719007628 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719007629 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 862719007630 putative ADP-binding pocket [chemical binding]; other site 862719007631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719007632 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719007633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719007634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719007635 DNA binding residues [nucleotide binding] 862719007636 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719007637 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719007638 Predicted integral membrane protein [Function unknown]; Region: COG5637 862719007639 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 862719007640 hydrophobic ligand binding site; other site 862719007641 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 862719007642 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719007643 NAD binding site [chemical binding]; other site 862719007644 catalytic Zn binding site [ion binding]; other site 862719007645 structural Zn binding site [ion binding]; other site 862719007646 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 862719007647 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 862719007648 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 862719007649 catalytic site [active] 862719007650 active site 862719007651 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 862719007652 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 862719007653 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 862719007654 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 862719007655 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 862719007656 NodB motif; other site 862719007657 active site 862719007658 catalytic site [active] 862719007659 metal binding site [ion binding]; metal-binding site 862719007660 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719007661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 862719007662 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719007663 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719007664 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 862719007665 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719007666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719007667 salt bridge; other site 862719007668 non-specific DNA binding site [nucleotide binding]; other site 862719007669 sequence-specific DNA binding site [nucleotide binding]; other site 862719007670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719007671 G1 box; other site 862719007672 GTP/Mg2+ binding site [chemical binding]; other site 862719007673 G2 box; other site 862719007674 Switch I region; other site 862719007675 G3 box; other site 862719007676 Switch II region; other site 862719007677 G4 box; other site 862719007678 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719007679 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719007680 substrate binding pocket [chemical binding]; other site 862719007681 membrane-bound complex binding site; other site 862719007682 hinge residues; other site 862719007683 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 862719007684 trimer interface [polypeptide binding]; other site 862719007685 active site 862719007686 dimer interface [polypeptide binding]; other site 862719007687 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 862719007688 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719007689 carboxyltransferase (CT) interaction site; other site 862719007690 biotinylation site [posttranslational modification]; other site 862719007691 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862719007692 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719007693 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719007694 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 862719007695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007696 PAS domain; Region: PAS_9; pfam13426 862719007697 putative active site [active] 862719007698 heme pocket [chemical binding]; other site 862719007699 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719007700 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 862719007701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007702 dimer interface [polypeptide binding]; other site 862719007703 putative CheW interface [polypeptide binding]; other site 862719007704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007705 PAS fold; Region: PAS_3; pfam08447 862719007706 putative active site [active] 862719007707 heme pocket [chemical binding]; other site 862719007708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719007709 PAS domain; Region: PAS_9; pfam13426 862719007710 PAS domain S-box; Region: sensory_box; TIGR00229 862719007711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007712 putative active site [active] 862719007713 heme pocket [chemical binding]; other site 862719007714 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719007715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007716 putative active site [active] 862719007717 heme pocket [chemical binding]; other site 862719007718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007719 dimer interface [polypeptide binding]; other site 862719007720 phosphorylation site [posttranslational modification] 862719007721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007722 ATP binding site [chemical binding]; other site 862719007723 Mg2+ binding site [ion binding]; other site 862719007724 G-X-G motif; other site 862719007725 CHASE domain; Region: CHASE; cl01369 862719007726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007728 ATP binding site [chemical binding]; other site 862719007729 Mg2+ binding site [ion binding]; other site 862719007730 G-X-G motif; other site 862719007731 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007733 active site 862719007734 phosphorylation site [posttranslational modification] 862719007735 intermolecular recognition site; other site 862719007736 dimerization interface [polypeptide binding]; other site 862719007737 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719007738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007739 active site 862719007740 phosphorylation site [posttranslational modification] 862719007741 intermolecular recognition site; other site 862719007742 PAS domain S-box; Region: sensory_box; TIGR00229 862719007743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007744 putative active site [active] 862719007745 heme pocket [chemical binding]; other site 862719007746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719007747 metal binding site [ion binding]; metal-binding site 862719007748 active site 862719007749 I-site; other site 862719007750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007751 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007752 active site 862719007753 phosphorylation site [posttranslational modification] 862719007754 intermolecular recognition site; other site 862719007755 dimerization interface [polypeptide binding]; other site 862719007756 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007758 active site 862719007759 phosphorylation site [posttranslational modification] 862719007760 intermolecular recognition site; other site 862719007761 dimerization interface [polypeptide binding]; other site 862719007762 NifQ; Region: NifQ; pfam04891 862719007763 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 862719007764 putative hydrophobic ligand binding site [chemical binding]; other site 862719007765 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 862719007766 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 862719007767 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719007768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719007769 protein binding site [polypeptide binding]; other site 862719007770 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 862719007771 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 862719007772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007773 active site 862719007774 phosphorylation site [posttranslational modification] 862719007775 intermolecular recognition site; other site 862719007776 dimerization interface [polypeptide binding]; other site 862719007777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719007778 DNA binding site [nucleotide binding] 862719007779 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 862719007780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719007781 dimerization interface [polypeptide binding]; other site 862719007782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007783 dimer interface [polypeptide binding]; other site 862719007784 phosphorylation site [posttranslational modification] 862719007785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007786 ATP binding site [chemical binding]; other site 862719007787 Mg2+ binding site [ion binding]; other site 862719007788 G-X-G motif; other site 862719007789 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719007790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719007791 putative substrate translocation pore; other site 862719007792 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 862719007793 active site 862719007794 multimer interface [polypeptide binding]; other site 862719007795 PAS domain; Region: PAS_9; pfam13426 862719007796 PAS fold; Region: PAS_7; pfam12860 862719007797 PAS domain S-box; Region: sensory_box; TIGR00229 862719007798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007799 dimer interface [polypeptide binding]; other site 862719007800 phosphorylation site [posttranslational modification] 862719007801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719007802 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007804 active site 862719007805 phosphorylation site [posttranslational modification] 862719007806 intermolecular recognition site; other site 862719007807 dimerization interface [polypeptide binding]; other site 862719007808 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 862719007809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007810 active site 862719007811 phosphorylation site [posttranslational modification] 862719007812 intermolecular recognition site; other site 862719007813 dimerization interface [polypeptide binding]; other site 862719007814 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719007815 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719007816 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719007817 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719007818 active site 862719007819 ATP binding site [chemical binding]; other site 862719007820 substrate binding site [chemical binding]; other site 862719007821 activation loop (A-loop); other site 862719007822 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 862719007823 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 862719007824 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719007825 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 862719007826 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 862719007827 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719007828 ligand binding site [chemical binding]; other site 862719007829 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 862719007830 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719007831 Sel1 repeat; Region: Sel1; cl02723 862719007832 Sel1 repeat; Region: Sel1; cl02723 862719007833 Sel1 repeat; Region: Sel1; cl02723 862719007834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007835 S-adenosylmethionine binding site [chemical binding]; other site 862719007836 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 862719007837 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 862719007838 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 862719007839 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 862719007840 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 862719007841 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 862719007842 ImpE protein; Region: ImpE; pfam07024 862719007843 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 862719007844 Protein of unknown function (DUF877); Region: DUF877; pfam05943 862719007845 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 862719007846 Protein of unknown function (DUF877); Region: DUF877; pfam05943 862719007847 Protein of unknown function (DUF770); Region: DUF770; cl01402 862719007848 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 862719007849 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 862719007850 PAAR motif; Region: PAAR_motif; cl15808 862719007851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007852 S-adenosylmethionine binding site [chemical binding]; other site 862719007853 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 862719007854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007855 Walker A motif; other site 862719007856 ATP binding site [chemical binding]; other site 862719007857 Walker B motif; other site 862719007858 arginine finger; other site 862719007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007860 Walker A motif; other site 862719007861 ATP binding site [chemical binding]; other site 862719007862 Walker B motif; other site 862719007863 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719007864 Protein of unknown function (DUF796); Region: DUF796; cl01226 862719007865 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 862719007866 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 862719007867 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 862719007868 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 862719007869 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 862719007870 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 862719007871 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719007872 phosphopeptide binding site; other site 862719007873 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 862719007874 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 862719007875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719007876 putative substrate translocation pore; other site 862719007877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719007878 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719007879 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719007880 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719007881 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719007882 anti sigma factor interaction site; other site 862719007883 regulatory phosphorylation site [posttranslational modification]; other site 862719007884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007885 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007886 active site 862719007887 phosphorylation site [posttranslational modification] 862719007888 intermolecular recognition site; other site 862719007889 dimerization interface [polypeptide binding]; other site 862719007890 BON domain; Region: BON; cl02771 862719007891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719007892 Helix-turn-helix domains; Region: HTH; cl00088 862719007893 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 862719007894 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719007895 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719007896 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 862719007897 Protein export membrane protein; Region: SecD_SecF; cl14618 862719007898 anthranilate synthase component I; Provisional; Region: PRK13573 862719007899 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719007900 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719007901 SurA N-terminal domain; Region: SurA_N_3; cl07813 862719007902 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 862719007903 PPIC-type PPIASE domain; Region: Rotamase; cl08278 862719007904 CsbD-like; Region: CsbD; cl15799 862719007905 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 862719007906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007907 PAS domain; Region: PAS_9; pfam13426 862719007908 putative active site [active] 862719007909 heme pocket [chemical binding]; other site 862719007910 PAS domain S-box; Region: sensory_box; TIGR00229 862719007911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007912 putative active site [active] 862719007913 heme pocket [chemical binding]; other site 862719007914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719007915 metal binding site [ion binding]; metal-binding site 862719007916 active site 862719007917 I-site; other site 862719007918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719007919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719007920 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719007921 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719007922 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 862719007923 Walker A/P-loop; other site 862719007924 ATP binding site [chemical binding]; other site 862719007925 Q-loop/lid; other site 862719007926 ABC transporter signature motif; other site 862719007927 Walker B; other site 862719007928 D-loop; other site 862719007929 H-loop/switch region; other site 862719007930 TOBE domain; Region: TOBE_2; cl01440 862719007931 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 862719007932 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719007933 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 862719007934 Walker A/P-loop; other site 862719007935 ATP binding site [chemical binding]; other site 862719007936 Q-loop/lid; other site 862719007937 ABC transporter signature motif; other site 862719007938 Walker B; other site 862719007939 D-loop; other site 862719007940 H-loop/switch region; other site 862719007941 hypothetical protein; Provisional; Region: PRK10279 862719007942 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 862719007943 active site 862719007944 nucleophile elbow; other site 862719007945 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719007946 potassium/proton antiporter; Reviewed; Region: PRK05326 862719007947 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 862719007948 Transporter associated domain; Region: CorC_HlyC; cl08393 862719007949 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719007950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719007951 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 862719007952 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 862719007953 G1 box; other site 862719007954 putative GEF interaction site [polypeptide binding]; other site 862719007955 GTP/Mg2+ binding site [chemical binding]; other site 862719007956 Switch I region; other site 862719007957 G2 box; other site 862719007958 G3 box; other site 862719007959 Switch II region; other site 862719007960 G4 box; other site 862719007961 G5 box; other site 862719007962 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 862719007963 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 862719007964 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 862719007965 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719007966 Surface antigen; Region: Bac_surface_Ag; cl03097 862719007967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 862719007968 AsmA-like C-terminal region; Region: AsmA_2; cl15864 862719007969 Family of unknown function (DUF490); Region: DUF490; pfam04357 862719007970 Helix-turn-helix domains; Region: HTH; cl00088 862719007971 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719007972 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 862719007973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719007974 catalytic residue [active] 862719007975 Cache domain; Region: Cache_2; cl07034 862719007976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 862719007977 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719007978 dimer interface [polypeptide binding]; other site 862719007979 putative CheW interface [polypeptide binding]; other site 862719007980 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 862719007981 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 862719007982 catalytic site [active] 862719007983 G-X2-G-X-G-K; other site 862719007984 hypothetical protein; Provisional; Region: PRK11820 862719007985 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 862719007986 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 862719007987 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 862719007988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007989 NAD(P) binding site [chemical binding]; other site 862719007990 active site 862719007991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 862719007992 ribonuclease D; Region: rnd; TIGR01388 862719007993 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 862719007994 catalytic site [active] 862719007995 putative active site [active] 862719007996 putative substrate binding site [chemical binding]; other site 862719007997 HRDC domain; Region: HRDC; cl02578 862719007998 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 862719007999 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 862719008000 dimer interface [polypeptide binding]; other site 862719008001 anticodon binding site; other site 862719008002 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 862719008003 homodimer interface [polypeptide binding]; other site 862719008004 motif 1; other site 862719008005 active site 862719008006 motif 2; other site 862719008007 GAD domain; Region: GAD; pfam02938 862719008008 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 862719008009 active site 862719008010 motif 3; other site 862719008011 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 862719008012 rRNA interaction site [nucleotide binding]; other site 862719008013 S8 interaction site; other site 862719008014 putative laminin-1 binding site; other site 862719008015 elongation factor Ts; Provisional; Region: tsf; PRK09377 862719008016 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 862719008017 Elongation factor TS; Region: EF_TS; pfam00889 862719008018 Elongation factor TS; Region: EF_TS; pfam00889 862719008019 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 862719008020 putative nucleotide binding site [chemical binding]; other site 862719008021 uridine monophosphate binding site [chemical binding]; other site 862719008022 homohexameric interface [polypeptide binding]; other site 862719008023 ribosome recycling factor; Reviewed; Region: frr; PRK00083 862719008024 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 862719008025 hinge region; other site 862719008026 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 862719008027 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 862719008028 catalytic residue [active] 862719008029 putative FPP diphosphate binding site; other site 862719008030 putative FPP binding hydrophobic cleft; other site 862719008031 dimer interface [polypeptide binding]; other site 862719008032 putative IPP diphosphate binding site; other site 862719008033 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 862719008034 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 862719008035 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 862719008036 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 862719008037 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 862719008038 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 862719008039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862719008040 active site 862719008041 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 862719008042 protein binding site [polypeptide binding]; other site 862719008043 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862719008044 putative substrate binding region [chemical binding]; other site 862719008045 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 862719008046 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719008047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719008048 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719008049 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719008050 Surface antigen; Region: Bac_surface_Ag; cl03097 862719008051 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 862719008052 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 862719008053 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 862719008054 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 862719008055 active site 862719008056 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 862719008057 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 862719008058 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 862719008059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719008060 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 862719008061 dimer interface [polypeptide binding]; other site 862719008062 active site 862719008063 metal binding site [ion binding]; metal-binding site 862719008064 glutathione binding site [chemical binding]; other site 862719008065 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 862719008066 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 862719008067 conserved cys residue [active] 862719008068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719008069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719008070 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 862719008071 active site residue [active] 862719008072 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 862719008073 dimer interface [polypeptide binding]; other site 862719008074 Citrate synthase; Region: Citrate_synt; pfam00285 862719008075 active site 862719008076 citrylCoA binding site [chemical binding]; other site 862719008077 NADH binding [chemical binding]; other site 862719008078 cationic pore residues; other site 862719008079 oxalacetate/citrate binding site [chemical binding]; other site 862719008080 coenzyme A binding site [chemical binding]; other site 862719008081 catalytic triad [active] 862719008082 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 862719008083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719008084 active site 862719008085 HIGH motif; other site 862719008086 nucleotide binding site [chemical binding]; other site 862719008087 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862719008088 active site 862719008089 KMSKS motif; other site 862719008090 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 862719008091 Competence protein; Region: Competence; cl00471 862719008092 LexA repressor; Validated; Region: PRK00215 862719008093 Helix-turn-helix domains; Region: HTH; cl00088 862719008094 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719008095 Catalytic site [active] 862719008096 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719008097 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719008098 dimer interface [polypeptide binding]; other site 862719008099 putative functional site; other site 862719008100 putative MPT binding site; other site 862719008101 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 862719008102 trimer interface [polypeptide binding]; other site 862719008103 dimer interface [polypeptide binding]; other site 862719008104 putative active site [active] 862719008105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719008106 Coenzyme A binding pocket [chemical binding]; other site 862719008107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719008108 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 862719008109 active site 862719008110 ribulose/triose binding site [chemical binding]; other site 862719008111 phosphate binding site [ion binding]; other site 862719008112 substrate (anthranilate) binding pocket [chemical binding]; other site 862719008113 product (indole) binding pocket [chemical binding]; other site 862719008114 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 862719008115 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719008116 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719008117 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 862719008118 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 862719008119 glutamine binding [chemical binding]; other site 862719008120 catalytic triad [active] 862719008121 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 862719008122 NodB motif; other site 862719008123 putative active site [active] 862719008124 putative catalytic site [active] 862719008125 Zn binding site [ion binding]; other site 862719008126 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719008127 metal-binding site [ion binding] 862719008128 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 862719008129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719008130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719008131 catalytic residue [active] 862719008132 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 862719008133 dihydrodipicolinate synthase; Region: dapA; TIGR00674 862719008134 dimer interface [polypeptide binding]; other site 862719008135 active site 862719008136 catalytic residue [active] 862719008137 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 862719008138 SmpB-tmRNA interface; other site 862719008139 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 862719008140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719008141 S-adenosylmethionine binding site [chemical binding]; other site 862719008142 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 862719008143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719008144 active site 862719008145 catalytic tetrad [active] 862719008146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719008147 Helix-turn-helix domains; Region: HTH; cl00088 862719008148 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719008149 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719008150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719008151 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 862719008152 substrate binding site [chemical binding]; other site 862719008153 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 862719008154 dimer interface [polypeptide binding]; other site 862719008155 allosteric magnesium binding site [ion binding]; other site 862719008156 active site 862719008157 aspartate-rich active site metal binding site; other site 862719008158 Schiff base residues; other site 862719008159 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719008160 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 862719008161 putative active site [active] 862719008162 putative metal binding site [ion binding]; other site 862719008163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719008164 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 862719008165 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 862719008166 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 862719008167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719008168 substrate binding site [chemical binding]; other site 862719008169 oxyanion hole (OAH) forming residues; other site 862719008170 trimer interface [polypeptide binding]; other site 862719008171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 862719008172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719008173 Helix-turn-helix domains; Region: HTH; cl00088 862719008174 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 862719008175 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719008176 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 862719008177 putative ligand binding site [chemical binding]; other site 862719008178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719008179 TM-ABC transporter signature motif; other site 862719008180 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719008181 TM-ABC transporter signature motif; other site 862719008182 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 862719008183 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719008184 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 862719008185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719008186 TPR motif; other site 862719008187 binding surface 862719008188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719008189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719008190 binding surface 862719008191 TPR motif; other site 862719008192 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 862719008193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719008195 S-adenosylmethionine binding site [chemical binding]; other site 862719008196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719008197 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719008198 short chain dehydrogenase; Provisional; Region: PRK06701 862719008199 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 862719008200 NAD binding site [chemical binding]; other site 862719008201 metal binding site [ion binding]; metal-binding site 862719008202 active site 862719008203 RNA polymerase sigma factor; Provisional; Region: PRK12547 862719008204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719008205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719008206 DNA binding residues [nucleotide binding] 862719008207 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719008208 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 862719008209 homodimer interface [polypeptide binding]; other site 862719008210 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 862719008211 active site pocket [active] 862719008212 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 862719008213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862719008215 Phage Tail Collar Domain; Region: Collar; pfam07484 862719008216 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 862719008217 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 862719008218 G1 box; other site 862719008219 putative GEF interaction site [polypeptide binding]; other site 862719008220 GTP/Mg2+ binding site [chemical binding]; other site 862719008221 Switch I region; other site 862719008222 G2 box; other site 862719008223 G3 box; other site 862719008224 Switch II region; other site 862719008225 G4 box; other site 862719008226 G5 box; other site 862719008227 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 862719008228 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719008229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008230 dimer interface [polypeptide binding]; other site 862719008231 phosphorylation site [posttranslational modification] 862719008232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008233 ATP binding site [chemical binding]; other site 862719008234 Mg2+ binding site [ion binding]; other site 862719008235 G-X-G motif; other site 862719008236 Response regulator receiver domain; Region: Response_reg; pfam00072 862719008237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008238 active site 862719008239 phosphorylation site [posttranslational modification] 862719008240 intermolecular recognition site; other site 862719008241 dimerization interface [polypeptide binding]; other site 862719008242 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 862719008243 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862719008244 Uncharacterized conserved protein [Function unknown]; Region: COG2308 862719008245 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 862719008246 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 862719008247 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 862719008248 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 862719008249 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862719008250 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 862719008251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 862719008252 short chain dehydrogenase; Provisional; Region: PRK06523 862719008253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008254 NAD(P) binding site [chemical binding]; other site 862719008255 active site 862719008256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719008257 Helix-turn-helix domains; Region: HTH; cl00088 862719008258 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 862719008259 putative effector binding pocket; other site 862719008260 putative dimerization interface [polypeptide binding]; other site 862719008261 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 862719008262 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 862719008263 active site 862719008264 catalytic residues [active] 862719008265 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719008266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719008267 active site 862719008268 ATP binding site [chemical binding]; other site 862719008269 substrate binding site [chemical binding]; other site 862719008270 activation loop (A-loop); other site 862719008271 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 862719008272 active site 862719008273 Dicarboxylate transport; Region: DctA-YdbH; cl14674 862719008274 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 862719008275 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 862719008276 TPR repeat; Region: TPR_11; pfam13414 862719008277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719008278 binding surface 862719008279 TPR motif; other site 862719008280 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719008281 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 862719008282 OstA-like protein; Region: OstA; cl00844 862719008283 Organic solvent tolerance protein; Region: OstA_C; pfam04453 862719008284 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 862719008285 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 862719008286 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 862719008287 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 862719008288 dimer interface [polypeptide binding]; other site 862719008289 active site 862719008290 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719008291 catalytic residues [active] 862719008292 substrate binding site [chemical binding]; other site 862719008293 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 862719008294 Cupin domain; Region: Cupin_2; cl09118 862719008295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719008296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719008297 putative substrate translocation pore; other site 862719008298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 862719008299 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 862719008300 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 862719008301 PQQ-like domain; Region: PQQ_2; pfam13360 862719008302 Trp docking motif [polypeptide binding]; other site 862719008303 active site 862719008304 GTP-binding protein Der; Reviewed; Region: PRK00093 862719008305 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 862719008306 G1 box; other site 862719008307 GTP/Mg2+ binding site [chemical binding]; other site 862719008308 Switch I region; other site 862719008309 G2 box; other site 862719008310 Switch II region; other site 862719008311 G3 box; other site 862719008312 G4 box; other site 862719008313 G5 box; other site 862719008314 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 862719008315 G1 box; other site 862719008316 GTP/Mg2+ binding site [chemical binding]; other site 862719008317 Switch I region; other site 862719008318 G2 box; other site 862719008319 G3 box; other site 862719008320 Switch II region; other site 862719008321 G4 box; other site 862719008322 G5 box; other site 862719008323 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719008324 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719008325 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719008326 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862719008327 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719008328 intersubunit interface [polypeptide binding]; other site 862719008329 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 862719008330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008331 Walker A/P-loop; other site 862719008332 ATP binding site [chemical binding]; other site 862719008333 Q-loop/lid; other site 862719008334 ABC transporter signature motif; other site 862719008335 Walker B; other site 862719008336 D-loop; other site 862719008337 H-loop/switch region; other site 862719008338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719008339 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719008340 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 862719008341 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 862719008342 Walker A/P-loop; other site 862719008343 ATP binding site [chemical binding]; other site 862719008344 Q-loop/lid; other site 862719008345 ABC transporter signature motif; other site 862719008346 Walker B; other site 862719008347 D-loop; other site 862719008348 H-loop/switch region; other site 862719008349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719008350 FtsX-like permease family; Region: FtsX; cl15850 862719008351 macrolide transporter subunit MacA; Provisional; Region: PRK11578 862719008352 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719008353 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719008354 Secretin and TonB N terminus short domain; Region: STN; cl06624 862719008355 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 862719008356 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719008357 N-terminal plug; other site 862719008358 ligand-binding site [chemical binding]; other site 862719008359 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719008360 FecR protein; Region: FecR; pfam04773 862719008361 RNA polymerase sigma factor; Reviewed; Region: PRK12527 862719008362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719008363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719008364 DNA binding residues [nucleotide binding] 862719008365 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 862719008366 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 862719008367 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719008368 dimer interface [polypeptide binding]; other site 862719008369 ADP-ribose binding site [chemical binding]; other site 862719008370 active site 862719008371 nudix motif; other site 862719008372 metal binding site [ion binding]; metal-binding site 862719008373 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862719008374 active site 862719008375 DNA repair protein RadA; Provisional; Region: PRK11823 862719008376 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 862719008377 Walker A motif/ATP binding site; other site 862719008378 ATP binding site [chemical binding]; other site 862719008379 Walker B motif; other site 862719008380 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 862719008381 Colicin V production protein; Region: Colicin_V; cl00567 862719008382 amidophosphoribosyltransferase; Provisional; Region: PRK09123 862719008383 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 862719008384 active site 862719008385 tetramer interface [polypeptide binding]; other site 862719008386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719008387 active site 862719008388 short chain dehydrogenase; Provisional; Region: PRK08703 862719008389 classical (c) SDRs; Region: SDR_c; cd05233 862719008390 NAD(P) binding site [chemical binding]; other site 862719008391 active site 862719008392 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 862719008393 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 862719008394 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 862719008395 active site 862719008396 substrate binding site [chemical binding]; other site 862719008397 cosubstrate binding site; other site 862719008398 catalytic site [active] 862719008399 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 862719008400 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 862719008401 dimerization interface [polypeptide binding]; other site 862719008402 putative ATP binding site [chemical binding]; other site 862719008403 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 862719008404 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719008405 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 862719008406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008407 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 862719008408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719008409 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 862719008410 putative NAD(P) binding site [chemical binding]; other site 862719008411 putative active site [active] 862719008412 Helix-turn-helix domains; Region: HTH; cl00088 862719008413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719008414 Archaeal ATPase; Region: Arch_ATPase; pfam01637 862719008415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008416 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719008417 O-Antigen ligase; Region: Wzy_C; cl04850 862719008418 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 862719008419 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 862719008420 putative metal binding site; other site 862719008421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719008422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719008423 sequence-specific DNA binding site [nucleotide binding]; other site 862719008424 salt bridge; other site 862719008425 putative glycosyl transferase; Provisional; Region: PRK10063 862719008426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719008427 active site 862719008428 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 862719008429 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 862719008430 SLBB domain; Region: SLBB; pfam10531 862719008431 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 862719008432 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719008433 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 862719008434 SprA-related family; Region: SprA-related; pfam12118 862719008435 N-carbamolyputrescine amidase; Region: PLN02747 862719008436 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 862719008437 putative active site; other site 862719008438 catalytic triad [active] 862719008439 putative dimer interface [polypeptide binding]; other site 862719008440 Helix-turn-helix domains; Region: HTH; cl00088 862719008441 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719008442 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719008443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008446 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008450 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719008451 PhoU domain; Region: PhoU; pfam01895 862719008452 PhoU domain; Region: PhoU; pfam01895 862719008453 anthranilate synthase; Provisional; Region: PRK13566 862719008454 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719008455 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719008456 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 862719008457 glutamine binding [chemical binding]; other site 862719008458 catalytic triad [active] 862719008459 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 862719008460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719008461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008462 dimer interface [polypeptide binding]; other site 862719008463 phosphorylation site [posttranslational modification] 862719008464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008465 ATP binding site [chemical binding]; other site 862719008466 Mg2+ binding site [ion binding]; other site 862719008467 G-X-G motif; other site 862719008468 osmolarity response regulator; Provisional; Region: ompR; PRK09468 862719008469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008470 active site 862719008471 phosphorylation site [posttranslational modification] 862719008472 intermolecular recognition site; other site 862719008473 dimerization interface [polypeptide binding]; other site 862719008474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719008475 DNA binding site [nucleotide binding] 862719008476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719008477 Helix-turn-helix domains; Region: HTH; cl00088 862719008478 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 862719008479 substrate binding site [chemical binding]; other site 862719008480 dimer interface [polypeptide binding]; other site 862719008481 catalytic triad [active] 862719008482 Preprotein translocase SecG subunit; Region: SecG; cl09123 862719008483 CTP synthetase; Validated; Region: pyrG; PRK05380 862719008484 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 862719008485 Catalytic site [active] 862719008486 active site 862719008487 UTP binding site [chemical binding]; other site 862719008488 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 862719008489 active site 862719008490 putative oxyanion hole; other site 862719008491 catalytic triad [active] 862719008492 Dienelactone hydrolase family; Region: DLH; pfam01738 862719008493 NeuB family; Region: NeuB; cl00496 862719008494 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 862719008495 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 862719008496 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719008497 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719008498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719008499 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 862719008500 Walker A/P-loop; other site 862719008501 ATP binding site [chemical binding]; other site 862719008502 Q-loop/lid; other site 862719008503 ABC transporter signature motif; other site 862719008504 Walker B; other site 862719008505 D-loop; other site 862719008506 H-loop/switch region; other site 862719008507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719008508 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 862719008509 FtsX-like permease family; Region: FtsX; cl15850 862719008510 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 862719008511 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 862719008512 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 862719008513 active site 862719008514 (T/H)XGH motif; other site 862719008515 DNA gyrase subunit A; Validated; Region: PRK05560 862719008516 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 862719008517 CAP-like domain; other site 862719008518 active site 862719008519 primary dimer interface [polypeptide binding]; other site 862719008520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008521 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008522 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008523 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008524 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008525 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719008526 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862719008527 MatE; Region: MatE; cl10513 862719008528 MatE; Region: MatE; cl10513 862719008529 Entericidin EcnA/B family; Region: Entericidin; cl02322 862719008530 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719008531 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719008532 Cupin domain; Region: Cupin_2; cl09118 862719008533 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 862719008534 homotrimer interface [polypeptide binding]; other site 862719008535 Walker A motif; other site 862719008536 GTP binding site [chemical binding]; other site 862719008537 Walker B motif; other site 862719008538 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 862719008539 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 862719008540 homodimer interface [polypeptide binding]; other site 862719008541 Walker A motif; other site 862719008542 ATP binding site [chemical binding]; other site 862719008543 hydroxycobalamin binding site [chemical binding]; other site 862719008544 Walker B motif; other site 862719008545 cobyric acid synthase; Provisional; Region: PRK00784 862719008546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008547 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008548 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 862719008549 catalytic triad [active] 862719008550 LytB protein; Region: LYTB; cl00507 862719008551 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 862719008552 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 862719008553 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 862719008554 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 862719008555 lipoyl attachment site [posttranslational modification]; other site 862719008556 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 862719008557 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 862719008558 tetramer interface [polypeptide binding]; other site 862719008559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719008560 catalytic residue [active] 862719008561 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 862719008562 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 862719008563 tetramer interface [polypeptide binding]; other site 862719008564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719008565 catalytic residue [active] 862719008566 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 862719008567 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719008568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719008569 active site 862719008570 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 862719008571 putative active site [active] 862719008572 putative substrate binding site [chemical binding]; other site 862719008573 ATP binding site [chemical binding]; other site 862719008574 excinuclease ABC subunit B; Provisional; Region: PRK05298 862719008575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719008576 ATP binding site [chemical binding]; other site 862719008577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719008578 nucleotide binding region [chemical binding]; other site 862719008579 ATP-binding site [chemical binding]; other site 862719008580 Ultra-violet resistance protein B; Region: UvrB; pfam12344 862719008581 Sel1 repeat; Region: Sel1; cl02723 862719008582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719008583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719008584 catalytic residue [active] 862719008585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719008586 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719008587 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719008588 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 862719008589 heme-binding site [chemical binding]; other site 862719008590 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719008591 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719008592 dimer interface [polypeptide binding]; other site 862719008593 putative CheW interface [polypeptide binding]; other site 862719008594 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719008595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719008596 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719008597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719008598 DNA binding residues [nucleotide binding] 862719008599 Predicted transcriptional regulator [Transcription]; Region: COG4957 862719008600 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719008601 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719008602 IHF - DNA interface [nucleotide binding]; other site 862719008603 IHF dimer interface [polypeptide binding]; other site 862719008604 Integral membrane protein TerC family; Region: TerC; cl10468 862719008605 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 862719008606 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 862719008607 AMP-binding enzyme; Region: AMP-binding; cl15778 862719008608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719008609 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 862719008610 dihydroorotase; Validated; Region: pyrC; PRK09357 862719008611 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719008612 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 862719008613 active site 862719008614 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 862719008615 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862719008616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008617 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719008618 Helix-turn-helix domains; Region: HTH; cl00088 862719008619 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719008620 dimerization interface [polypeptide binding]; other site 862719008621 substrate binding pocket [chemical binding]; other site 862719008622 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 862719008623 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 862719008624 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 862719008625 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719008626 Iron permease FTR1 family; Region: FTR1; cl00475 862719008627 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862719008628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008629 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 862719008630 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 862719008631 Walker A/P-loop; other site 862719008632 ATP binding site [chemical binding]; other site 862719008633 Q-loop/lid; other site 862719008634 ABC transporter signature motif; other site 862719008635 Walker B; other site 862719008636 D-loop; other site 862719008637 H-loop/switch region; other site 862719008638 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 862719008639 TM-ABC transporter signature motif; other site 862719008640 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 862719008641 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719008642 zinc binding site [ion binding]; other site 862719008643 putative ligand binding site [chemical binding]; other site 862719008644 Protein of unknown function (DUF983); Region: DUF983; cl02211 862719008645 pteridine reductase; Provisional; Region: PRK09135 862719008646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008647 NAD(P) binding site [chemical binding]; other site 862719008648 active site 862719008649 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862719008650 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862719008651 GIY-YIG motif/motif A; other site 862719008652 active site 862719008653 catalytic site [active] 862719008654 putative DNA binding site [nucleotide binding]; other site 862719008655 metal binding site [ion binding]; metal-binding site 862719008656 UvrB/uvrC motif; Region: UVR; pfam02151 862719008657 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862719008658 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719008659 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 862719008660 Walker A motif; other site 862719008661 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719008662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719008663 motif II; other site 862719008664 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719008665 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719008666 dimer interface [polypeptide binding]; other site 862719008667 putative functional site; other site 862719008668 putative MPT binding site; other site 862719008669 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862719008670 MoaE interaction surface [polypeptide binding]; other site 862719008671 MoeB interaction surface [polypeptide binding]; other site 862719008672 thiocarboxylated glycine; other site 862719008673 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 862719008674 MoaE homodimer interface [polypeptide binding]; other site 862719008675 MoaD interaction [polypeptide binding]; other site 862719008676 active site residues [active] 862719008677 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 862719008678 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 862719008679 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 862719008680 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 862719008681 DsbD alpha interface [polypeptide binding]; other site 862719008682 catalytic residues [active] 862719008683 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 862719008684 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 862719008685 PhnA protein; Region: PhnA; pfam03831 862719008686 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 862719008687 catalytic triad [active] 862719008688 dimer interface [polypeptide binding]; other site 862719008689 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 862719008690 RNA/DNA hybrid binding site [nucleotide binding]; other site 862719008691 active site 862719008692 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 862719008693 Phosphotransferase enzyme family; Region: APH; pfam01636 862719008694 putative active site [active] 862719008695 putative substrate binding site [chemical binding]; other site 862719008696 ATP binding site [chemical binding]; other site 862719008697 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 862719008698 dinuclear metal binding motif [ion binding]; other site 862719008699 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 862719008700 active site 862719008701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719008702 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719008703 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719008704 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719008705 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 862719008706 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 862719008707 Catalytic site; other site 862719008708 two-component response regulator; Provisional; Region: PRK09191 862719008709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719008710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008711 active site 862719008712 phosphorylation site [posttranslational modification] 862719008713 intermolecular recognition site; other site 862719008714 dimerization interface [polypeptide binding]; other site 862719008715 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 862719008716 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862719008717 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 862719008718 substrate binding site [chemical binding]; other site 862719008719 hexamer interface [polypeptide binding]; other site 862719008720 metal binding site [ion binding]; metal-binding site 862719008721 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 862719008722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719008723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008724 dimer interface [polypeptide binding]; other site 862719008725 conserved gate region; other site 862719008726 putative PBP binding loops; other site 862719008727 ABC-ATPase subunit interface; other site 862719008728 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 862719008729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008730 Walker A/P-loop; other site 862719008731 ATP binding site [chemical binding]; other site 862719008732 Q-loop/lid; other site 862719008733 ABC transporter signature motif; other site 862719008734 Walker B; other site 862719008735 D-loop; other site 862719008736 H-loop/switch region; other site 862719008737 TOBE domain; Region: TOBE_2; cl01440 862719008738 Septum formation initiator; Region: DivIC; cl11433 862719008739 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719008740 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719008741 tetramer interface [polypeptide binding]; other site 862719008742 TPP-binding site [chemical binding]; other site 862719008743 heterodimer interface [polypeptide binding]; other site 862719008744 phosphorylation loop region [posttranslational modification] 862719008745 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 862719008746 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719008747 E3 interaction surface; other site 862719008748 lipoyl attachment site [posttranslational modification]; other site 862719008749 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719008750 alpha subunit interface [polypeptide binding]; other site 862719008751 TPP binding site [chemical binding]; other site 862719008752 heterodimer interface [polypeptide binding]; other site 862719008753 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719008754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719008755 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 862719008756 E3 interaction surface; other site 862719008757 lipoyl attachment site [posttranslational modification]; other site 862719008758 e3 binding domain; Region: E3_binding; pfam02817 862719008759 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 862719008760 Chorismate mutase type II; Region: CM_2; cl00693 862719008761 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 862719008762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719008763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719008764 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719008765 lipoyl synthase; Provisional; Region: PRK05481 862719008766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719008767 FeS/SAM binding site; other site 862719008768 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 862719008769 putative coenzyme Q binding site [chemical binding]; other site 862719008770 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 862719008771 active site 1 [active] 862719008772 dimer interface [polypeptide binding]; other site 862719008773 hexamer interface [polypeptide binding]; other site 862719008774 active site 2 [active] 862719008775 Competence-damaged protein; Region: CinA; cl00666 862719008776 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 862719008777 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 862719008778 substrate binding site; other site 862719008779 dimer interface; other site 862719008780 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 862719008781 homotrimer interaction site [polypeptide binding]; other site 862719008782 zinc binding site [ion binding]; other site 862719008783 CDP-binding sites; other site 862719008784 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 862719008785 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 862719008786 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862719008787 FMN binding site [chemical binding]; other site 862719008788 active site 862719008789 catalytic residues [active] 862719008790 substrate binding site [chemical binding]; other site 862719008791 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719008792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719008793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008794 dimer interface [polypeptide binding]; other site 862719008795 phosphorylation site [posttranslational modification] 862719008796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008797 ATP binding site [chemical binding]; other site 862719008798 Mg2+ binding site [ion binding]; other site 862719008799 G-X-G motif; other site 862719008800 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 862719008801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008802 active site 862719008803 phosphorylation site [posttranslational modification] 862719008804 intermolecular recognition site; other site 862719008805 dimerization interface [polypeptide binding]; other site 862719008806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719008807 Walker A motif; other site 862719008808 ATP binding site [chemical binding]; other site 862719008809 Walker B motif; other site 862719008810 arginine finger; other site 862719008811 Helix-turn-helix domains; Region: HTH; cl00088 862719008812 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719008813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719008814 dimerization interface [polypeptide binding]; other site 862719008815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008816 dimer interface [polypeptide binding]; other site 862719008817 phosphorylation site [posttranslational modification] 862719008818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008819 ATP binding site [chemical binding]; other site 862719008820 Mg2+ binding site [ion binding]; other site 862719008821 G-X-G motif; other site 862719008822 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719008823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008824 active site 862719008825 phosphorylation site [posttranslational modification] 862719008826 intermolecular recognition site; other site 862719008827 dimerization interface [polypeptide binding]; other site 862719008828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719008829 Walker A motif; other site 862719008830 ATP binding site [chemical binding]; other site 862719008831 Walker B motif; other site 862719008832 arginine finger; other site 862719008833 Helix-turn-helix domains; Region: HTH; cl00088 862719008834 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719008835 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 862719008836 putative active site [active] 862719008837 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 862719008838 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719008839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719008840 motif II; other site 862719008841 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 862719008842 Sm1 motif; other site 862719008843 intra - hexamer interaction site; other site 862719008844 inter - hexamer interaction site [polypeptide binding]; other site 862719008845 nucleotide binding pocket [chemical binding]; other site 862719008846 Sm2 motif; other site 862719008847 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 862719008848 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 862719008849 HflX GTPase family; Region: HflX; cd01878 862719008850 G1 box; other site 862719008851 GTP/Mg2+ binding site [chemical binding]; other site 862719008852 Switch I region; other site 862719008853 G2 box; other site 862719008854 G3 box; other site 862719008855 Switch II region; other site 862719008856 G4 box; other site 862719008857 G5 box; other site 862719008858 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 862719008859 active site 862719008860 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719008861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719008862 Ligand Binding Site [chemical binding]; other site 862719008863 NMT1/THI5 like; Region: NMT1; pfam09084 862719008864 NMT1-like family; Region: NMT1_2; cl15260 862719008865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719008866 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719008867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008868 Walker A/P-loop; other site 862719008869 ATP binding site [chemical binding]; other site 862719008870 Q-loop/lid; other site 862719008871 ABC transporter signature motif; other site 862719008872 Walker B; other site 862719008873 D-loop; other site 862719008874 H-loop/switch region; other site 862719008875 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719008876 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 862719008877 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 862719008878 Response regulator receiver domain; Region: Response_reg; pfam00072 862719008879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008880 active site 862719008881 phosphorylation site [posttranslational modification] 862719008882 intermolecular recognition site; other site 862719008883 dimerization interface [polypeptide binding]; other site 862719008884 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862719008885 dimer interface [polypeptide binding]; other site 862719008886 ssDNA binding site [nucleotide binding]; other site 862719008887 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862719008888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719008889 Helix-turn-helix domains; Region: HTH; cl00088 862719008890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719008891 dimerization interface [polypeptide binding]; other site 862719008892 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719008893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719008894 putative substrate translocation pore; other site 862719008895 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 862719008896 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 862719008897 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 862719008898 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 862719008899 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862719008900 MoxR-like ATPases [General function prediction only]; Region: COG0714 862719008901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719008902 Walker A motif; other site 862719008903 ATP binding site [chemical binding]; other site 862719008904 Walker B motif; other site 862719008905 arginine finger; other site 862719008906 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 862719008907 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 862719008908 putative active site [active] 862719008909 putative CoA binding site [chemical binding]; other site 862719008910 nudix motif; other site 862719008911 metal binding site [ion binding]; metal-binding site 862719008912 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 862719008913 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 862719008914 active site 862719008915 NTP binding site [chemical binding]; other site 862719008916 metal binding triad [ion binding]; metal-binding site 862719008917 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 862719008918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719008919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719008920 classical (c) SDRs; Region: SDR_c; cd05233 862719008921 NAD(P) binding site [chemical binding]; other site 862719008922 active site 862719008923 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 862719008924 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 862719008925 polyphosphate kinase; Provisional; Region: PRK05443 862719008926 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 862719008927 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 862719008928 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 862719008929 putative domain interface [polypeptide binding]; other site 862719008930 putative active site [active] 862719008931 catalytic site [active] 862719008932 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 862719008933 putative domain interface [polypeptide binding]; other site 862719008934 putative active site [active] 862719008935 catalytic site [active] 862719008936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719008937 catalytic core [active] 862719008938 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 862719008939 putative active site [active] 862719008940 putative metal binding residues [ion binding]; other site 862719008941 signature motif; other site 862719008942 putative triphosphate binding site [ion binding]; other site 862719008943 CHAD domain; Region: CHAD; cl10506 862719008944 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 862719008945 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 862719008946 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 862719008947 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 862719008948 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 862719008949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008950 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 862719008951 substrate binding pocket [chemical binding]; other site 862719008952 substrate-Mg2+ binding site; other site 862719008953 aspartate-rich region 1; other site 862719008954 aspartate-rich region 2; other site 862719008955 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 862719008956 active site lid residues [active] 862719008957 substrate binding pocket [chemical binding]; other site 862719008958 catalytic residues [active] 862719008959 substrate-Mg2+ binding site; other site 862719008960 aspartate-rich region 1; other site 862719008961 aspartate-rich region 2; other site 862719008962 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 862719008963 active site lid residues [active] 862719008964 substrate binding pocket [chemical binding]; other site 862719008965 catalytic residues [active] 862719008966 substrate-Mg2+ binding site; other site 862719008967 aspartate-rich region 1; other site 862719008968 aspartate-rich region 2; other site 862719008969 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 862719008970 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 862719008971 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 862719008972 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 862719008973 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 862719008974 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 862719008975 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 862719008976 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 862719008977 Protein export membrane protein; Region: SecD_SecF; cl14618 862719008978 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 862719008979 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 862719008980 Protein export membrane protein; Region: SecD_SecF; cl14618 862719008981 Preprotein translocase subunit; Region: YajC; cl00806 862719008982 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 862719008983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719008984 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 862719008985 putative peptidoglycan binding site; other site 862719008986 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 862719008987 putative peptidoglycan binding site; other site 862719008988 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719008989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008990 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 862719008991 Survival protein SurE; Region: SurE; cl00448 862719008992 seryl-tRNA synthetase; Provisional; Region: PRK05431 862719008993 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 862719008994 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 862719008995 dimer interface [polypeptide binding]; other site 862719008996 active site 862719008997 motif 1; other site 862719008998 motif 2; other site 862719008999 motif 3; other site 862719009000 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009001 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719009002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009003 active site 862719009004 phosphorylation site [posttranslational modification] 862719009005 intermolecular recognition site; other site 862719009006 dimerization interface [polypeptide binding]; other site 862719009007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719009008 DNA binding residues [nucleotide binding] 862719009009 dimerization interface [polypeptide binding]; other site 862719009010 transcriptional regulator FimZ; Provisional; Region: PRK09935 862719009011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719009012 DNA binding residues [nucleotide binding] 862719009013 dimerization interface [polypeptide binding]; other site 862719009014 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 862719009015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719009016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009017 dimer interface [polypeptide binding]; other site 862719009018 putative CheW interface [polypeptide binding]; other site 862719009019 PilZ domain; Region: PilZ; cl01260 862719009020 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 862719009021 dimer interface [polypeptide binding]; other site 862719009022 putative tRNA-binding site [nucleotide binding]; other site 862719009023 Phasin protein; Region: Phasin_2; cl11491 862719009024 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 862719009025 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 862719009026 putative deacylase active site [active] 862719009027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009028 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 862719009029 Membrane fusogenic activity; Region: BMFP; cl01115 862719009030 AsmA family; Region: AsmA; pfam05170 862719009031 putative assembly protein; Provisional; Region: PRK10833 862719009032 AsmA-like C-terminal region; Region: AsmA_2; cl15864 862719009033 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 862719009034 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 862719009035 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 862719009036 NAD(P) binding site [chemical binding]; other site 862719009037 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 862719009038 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 862719009039 Flavoprotein; Region: Flavoprotein; cl08021 862719009040 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 862719009041 active site clefts [active] 862719009042 zinc binding site [ion binding]; other site 862719009043 dimer interface [polypeptide binding]; other site 862719009044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009045 binding surface 862719009046 TPR motif; other site 862719009047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009048 binding surface 862719009049 TPR repeat; Region: TPR_11; pfam13414 862719009050 TPR motif; other site 862719009051 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 862719009052 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 862719009053 active site 862719009054 ADP/pyrophosphate binding site [chemical binding]; other site 862719009055 dimerization interface [polypeptide binding]; other site 862719009056 allosteric effector site; other site 862719009057 fructose-1,6-bisphosphate binding site; other site 862719009058 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 862719009059 apolar tunnel; other site 862719009060 heme binding site [chemical binding]; other site 862719009061 dimerization interface [polypeptide binding]; other site 862719009062 AIR carboxylase; Region: AIRC; cl00310 862719009063 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 862719009064 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719009065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719009066 putative active site [active] 862719009067 heme pocket [chemical binding]; other site 862719009068 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719009069 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009070 Protein of unknown function, DUF599; Region: DUF599; cl01575 862719009071 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719009072 fumarate hydratase; Reviewed; Region: fumC; PRK00485 862719009073 Class II fumarases; Region: Fumarase_classII; cd01362 862719009074 active site 862719009075 tetramer interface [polypeptide binding]; other site 862719009076 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719009078 Coenzyme A binding pocket [chemical binding]; other site 862719009079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719009080 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719009081 Transglycosylase SLT domain; Region: SLT_2; pfam13406 862719009082 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719009083 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719009084 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009086 active site 862719009087 phosphorylation site [posttranslational modification] 862719009088 intermolecular recognition site; other site 862719009089 dimerization interface [polypeptide binding]; other site 862719009090 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 862719009091 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719009092 dimer interface [polypeptide binding]; other site 862719009093 PYR/PP interface [polypeptide binding]; other site 862719009094 TPP binding site [chemical binding]; other site 862719009095 substrate binding site [chemical binding]; other site 862719009096 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 862719009097 TPP-binding site; other site 862719009098 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 862719009099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719009100 PAS fold; Region: PAS_7; pfam12860 862719009101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719009102 PAS fold; Region: PAS_7; pfam12860 862719009103 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719009104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009105 dimer interface [polypeptide binding]; other site 862719009106 phosphorylation site [posttranslational modification] 862719009107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009108 ATP binding site [chemical binding]; other site 862719009109 Mg2+ binding site [ion binding]; other site 862719009110 G-X-G motif; other site 862719009111 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 862719009112 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 862719009113 active site 862719009114 Zn binding site [ion binding]; other site 862719009115 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 862719009116 Protein of unknown function (DUF983); Region: DUF983; cl02211 862719009117 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 862719009118 Subunit III/VIIa interface [polypeptide binding]; other site 862719009119 Phospholipid binding site [chemical binding]; other site 862719009120 Subunit I/III interface [polypeptide binding]; other site 862719009121 Subunit III/VIb interface [polypeptide binding]; other site 862719009122 Subunit III/VIa interface; other site 862719009123 Subunit III/Vb interface [polypeptide binding]; other site 862719009124 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 862719009125 UbiA prenyltransferase family; Region: UbiA; cl00337 862719009126 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 862719009127 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 862719009128 Subunit I/III interface [polypeptide binding]; other site 862719009129 D-pathway; other site 862719009130 Subunit I/VIIc interface [polypeptide binding]; other site 862719009131 Subunit I/IV interface [polypeptide binding]; other site 862719009132 Subunit I/II interface [polypeptide binding]; other site 862719009133 Low-spin heme (heme a) binding site [chemical binding]; other site 862719009134 Subunit I/VIIa interface [polypeptide binding]; other site 862719009135 Subunit I/VIa interface [polypeptide binding]; other site 862719009136 Dimer interface; other site 862719009137 Putative water exit pathway; other site 862719009138 Binuclear center (heme a3/CuB) [ion binding]; other site 862719009139 K-pathway; other site 862719009140 Subunit I/Vb interface [polypeptide binding]; other site 862719009141 Putative proton exit pathway; other site 862719009142 Subunit I/VIb interface; other site 862719009143 Subunit I/VIc interface [polypeptide binding]; other site 862719009144 Electron transfer pathway; other site 862719009145 Subunit I/VIIIb interface [polypeptide binding]; other site 862719009146 Subunit I/VIIb interface [polypeptide binding]; other site 862719009147 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 862719009148 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 862719009149 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009150 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 862719009151 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 862719009152 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 862719009153 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 862719009154 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862719009155 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 862719009156 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 862719009157 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 862719009158 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 862719009159 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 862719009160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719009161 ATP binding site [chemical binding]; other site 862719009162 putative Mg++ binding site [ion binding]; other site 862719009163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719009164 nucleotide binding region [chemical binding]; other site 862719009165 ATP-binding site [chemical binding]; other site 862719009166 TRCF domain; Region: TRCF; cl04088 862719009167 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862719009168 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 862719009169 Helix-turn-helix domains; Region: HTH; cl00088 862719009170 WHG domain; Region: WHG; pfam13305 862719009171 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 862719009172 nucleotide binding site/active site [active] 862719009173 HIT family signature motif; other site 862719009174 catalytic residue [active] 862719009175 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 862719009176 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719009177 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 862719009178 Ligand binding site; other site 862719009179 DXD motif; other site 862719009180 Cupin domain; Region: Cupin_2; cl09118 862719009181 recombinase A; Provisional; Region: recA; PRK09354 862719009182 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 862719009183 hexamer interface [polypeptide binding]; other site 862719009184 Walker A motif; other site 862719009185 ATP binding site [chemical binding]; other site 862719009186 Walker B motif; other site 862719009187 hypothetical protein; Provisional; Region: PRK13560 862719009188 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719009189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009190 putative active site [active] 862719009191 heme pocket [chemical binding]; other site 862719009192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009193 dimer interface [polypeptide binding]; other site 862719009194 phosphorylation site [posttranslational modification] 862719009195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009196 ATP binding site [chemical binding]; other site 862719009197 Mg2+ binding site [ion binding]; other site 862719009198 G-X-G motif; other site 862719009199 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009201 active site 862719009202 phosphorylation site [posttranslational modification] 862719009203 intermolecular recognition site; other site 862719009204 dimerization interface [polypeptide binding]; other site 862719009205 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 862719009206 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 862719009207 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 862719009208 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 862719009209 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 862719009210 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 862719009211 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719009212 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 862719009213 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719009214 Evidence 2b : Function of strongly homologous gene; Product type s : structure 862719009215 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 862719009216 FliP family; Region: FliP; cl00593 862719009217 K+ potassium transporter; Region: K_trans; cl15781 862719009218 potassium uptake protein; Region: kup; TIGR00794 862719009219 Fasciclin domain; Region: Fasciclin; cl02663 862719009220 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719009221 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 862719009222 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719009223 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 862719009224 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 862719009225 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719009226 hypothetical protein; Provisional; Region: PRK10279 862719009227 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 862719009228 active site 862719009229 nucleophile elbow; other site 862719009230 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 862719009231 active site 862719009232 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719009233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719009234 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719009235 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 862719009236 GTPase Era; Reviewed; Region: era; PRK00089 862719009237 G1 box; other site 862719009238 GTP/Mg2+ binding site [chemical binding]; other site 862719009239 Switch I region; other site 862719009240 G2 box; other site 862719009241 Switch II region; other site 862719009242 G3 box; other site 862719009243 G4 box; other site 862719009244 G5 box; other site 862719009245 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 862719009246 ribonuclease III; Reviewed; Region: rnc; PRK00102 862719009247 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 862719009248 dimerization interface [polypeptide binding]; other site 862719009249 active site 862719009250 metal binding site [ion binding]; metal-binding site 862719009251 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 862719009252 dsRNA binding site [nucleotide binding]; other site 862719009253 signal peptidase I; Provisional; Region: PRK10861 862719009254 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862719009255 Catalytic site [active] 862719009256 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862719009257 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 862719009258 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 862719009259 active site 862719009260 hydrophilic channel; other site 862719009261 dimerization interface [polypeptide binding]; other site 862719009262 catalytic residues [active] 862719009263 active site lid [active] 862719009264 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 862719009265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719009266 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 862719009267 synthetase active site [active] 862719009268 NTP binding site [chemical binding]; other site 862719009269 metal binding site [ion binding]; metal-binding site 862719009270 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 862719009271 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 862719009272 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 862719009273 LabA_like proteins; Region: LabA; cd10911 862719009274 putative metal binding site [ion binding]; other site 862719009275 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 862719009276 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 862719009277 SurA N-terminal domain; Region: SurA_N_3; cl07813 862719009278 PPIC-type PPIASE domain; Region: Rotamase; cl08278 862719009279 PPIC-type PPIASE domain; Region: Rotamase; cl08278 862719009280 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 862719009281 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862719009282 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719009283 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719009284 GMP synthase; Reviewed; Region: guaA; PRK00074 862719009285 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 862719009286 AMP/PPi binding site [chemical binding]; other site 862719009287 candidate oxyanion hole; other site 862719009288 catalytic triad [active] 862719009289 potential glutamine specificity residues [chemical binding]; other site 862719009290 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 862719009291 ATP Binding subdomain [chemical binding]; other site 862719009292 Ligand Binding sites [chemical binding]; other site 862719009293 Dimerization subdomain; other site 862719009294 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719009295 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719009296 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719009297 catalytic residue [active] 862719009298 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719009299 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719009300 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719009301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719009302 Protein export membrane protein; Region: SecD_SecF; cl14618 862719009303 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 862719009304 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 862719009305 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862719009306 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 862719009307 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719009308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719009309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719009310 nucleotide binding region [chemical binding]; other site 862719009311 ATP-binding site [chemical binding]; other site 862719009312 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 862719009313 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 862719009314 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 862719009315 SlyX; Region: SlyX; cl01090 862719009316 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009317 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009318 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009319 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719009320 Helix-turn-helix domains; Region: HTH; cl00088 862719009321 Helix-turn-helix domains; Region: HTH; cl00088 862719009322 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 862719009323 Transglycosylase; Region: Transgly; cl07896 862719009324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719009325 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 862719009326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009327 binding surface 862719009328 TPR motif; other site 862719009329 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 862719009330 MG2 domain; Region: A2M_N; pfam01835 862719009331 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 862719009332 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 862719009333 Alpha-2-macroglobulin family; Region: A2M; pfam00207 862719009334 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 862719009335 surface patch; other site 862719009336 thioester region; other site 862719009337 specificity defining residues; other site 862719009338 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719009339 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719009340 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 862719009341 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 862719009342 Helix-turn-helix domains; Region: HTH; cl00088 862719009343 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 862719009344 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 862719009345 putative dimerization interface [polypeptide binding]; other site 862719009346 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719009347 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719009348 dimer interface [polypeptide binding]; other site 862719009349 putative functional site; other site 862719009350 putative MPT binding site; other site 862719009351 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 862719009352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719009353 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719009354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009355 ATP binding site [chemical binding]; other site 862719009356 Mg2+ binding site [ion binding]; other site 862719009357 G-X-G motif; other site 862719009358 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 862719009359 putative active site [active] 862719009360 homoserine dehydrogenase; Provisional; Region: PRK06349 862719009361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009362 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 862719009363 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 862719009364 aminotransferase; Validated; Region: PRK09148 862719009365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719009366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009367 homodimer interface [polypeptide binding]; other site 862719009368 catalytic residue [active] 862719009369 Nitrate and nitrite sensing; Region: NIT; pfam08376 862719009370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719009371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009372 dimer interface [polypeptide binding]; other site 862719009373 putative CheW interface [polypeptide binding]; other site 862719009374 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719009375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009376 active site 862719009377 phosphorylation site [posttranslational modification] 862719009378 intermolecular recognition site; other site 862719009379 dimerization interface [polypeptide binding]; other site 862719009380 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 862719009381 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719009382 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 862719009383 tandem repeat interface [polypeptide binding]; other site 862719009384 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 862719009385 oligomer interface [polypeptide binding]; other site 862719009386 active site residues [active] 862719009387 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 862719009388 tandem repeat interface [polypeptide binding]; other site 862719009389 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 862719009390 oligomer interface [polypeptide binding]; other site 862719009391 active site residues [active] 862719009392 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862719009393 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719009394 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719009395 ABC transporter; Region: ABC_tran_2; pfam12848 862719009396 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719009397 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 862719009398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009399 S-adenosylmethionine binding site [chemical binding]; other site 862719009400 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 862719009401 MutS domain I; Region: MutS_I; pfam01624 862719009402 MutS domain II; Region: MutS_II; pfam05188 862719009403 MutS family domain IV; Region: MutS_IV; pfam05190 862719009404 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 862719009405 Walker A/P-loop; other site 862719009406 ATP binding site [chemical binding]; other site 862719009407 Q-loop/lid; other site 862719009408 ABC transporter signature motif; other site 862719009409 Walker B; other site 862719009410 D-loop; other site 862719009411 H-loop/switch region; other site 862719009412 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 862719009413 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862719009414 HIGH motif; other site 862719009415 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862719009416 active site 862719009417 KMSKS motif; other site 862719009418 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 862719009419 tRNA binding surface [nucleotide binding]; other site 862719009420 anticodon binding site; other site 862719009421 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 862719009422 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 862719009423 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 862719009424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719009425 active site residue [active] 862719009426 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 862719009427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009428 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719009429 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719009430 protein binding site [polypeptide binding]; other site 862719009431 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 862719009432 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719009433 dimer interface [polypeptide binding]; other site 862719009434 ADP-ribose binding site [chemical binding]; other site 862719009435 active site 862719009436 nudix motif; other site 862719009437 metal binding site [ion binding]; metal-binding site 862719009438 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719009439 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 862719009440 dimer interface [polypeptide binding]; other site 862719009441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009442 catalytic residue [active] 862719009443 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1712632, 6256345, 7005898, 7025207; Product type e : enzyme 862719009444 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 862719009445 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 862719009446 active site residue [active] 862719009447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719009448 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 862719009449 active site residue [active] 862719009450 putative acetyltransferase; Provisional; Region: PRK03624 862719009451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719009452 Coenzyme A binding pocket [chemical binding]; other site 862719009453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719009454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719009455 Coenzyme A binding pocket [chemical binding]; other site 862719009456 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 862719009457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719009458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009459 homodimer interface [polypeptide binding]; other site 862719009460 catalytic residue [active] 862719009461 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719009462 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 862719009463 Walker A/P-loop; other site 862719009464 ATP binding site [chemical binding]; other site 862719009465 Q-loop/lid; other site 862719009466 ABC transporter signature motif; other site 862719009467 Walker B; other site 862719009468 D-loop; other site 862719009469 H-loop/switch region; other site 862719009470 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719009471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719009472 dimer interface [polypeptide binding]; other site 862719009473 conserved gate region; other site 862719009474 putative PBP binding loops; other site 862719009475 ABC-ATPase subunit interface; other site 862719009476 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 862719009477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719009478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719009479 dimer interface [polypeptide binding]; other site 862719009480 conserved gate region; other site 862719009481 putative PBP binding loops; other site 862719009482 ABC-ATPase subunit interface; other site 862719009483 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719009484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719009485 substrate binding pocket [chemical binding]; other site 862719009486 membrane-bound complex binding site; other site 862719009487 hinge residues; other site 862719009488 cystathionine beta-lyase; Provisional; Region: PRK09028 862719009489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719009490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719009491 catalytic residue [active] 862719009492 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 862719009493 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719009494 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719009495 DctM-like transporters; Region: DctM; pfam06808 862719009496 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719009497 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 862719009498 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 862719009499 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719009500 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 862719009501 Uncharacterized conserved protein [Function unknown]; Region: COG2308 862719009502 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 862719009503 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 862719009504 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719009505 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 862719009506 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719009507 ligand binding site [chemical binding]; other site 862719009508 Flavin Reductases; Region: FlaRed; cl00801 862719009509 SCP-2 sterol transfer family; Region: SCP2; cl01225 862719009510 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 862719009511 AMP-binding enzyme; Region: AMP-binding; cl15778 862719009512 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719009513 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719009514 DNA binding residues [nucleotide binding] 862719009515 putative dimer interface [polypeptide binding]; other site 862719009516 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719009517 active site 862719009518 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719009519 Ligand binding site [chemical binding]; other site 862719009520 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719009521 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719009522 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719009523 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719009524 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 862719009525 PAS fold; Region: PAS_3; pfam08447 862719009526 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719009527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009528 PAS fold; Region: PAS_3; pfam08447 862719009529 putative active site [active] 862719009530 heme pocket [chemical binding]; other site 862719009531 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719009532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009533 ATP binding site [chemical binding]; other site 862719009534 Mg2+ binding site [ion binding]; other site 862719009535 G-X-G motif; other site 862719009536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719009537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719009538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009539 ATP binding site [chemical binding]; other site 862719009540 Mg2+ binding site [ion binding]; other site 862719009541 G-X-G motif; other site 862719009542 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719009543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009544 active site 862719009545 phosphorylation site [posttranslational modification] 862719009546 intermolecular recognition site; other site 862719009547 dimerization interface [polypeptide binding]; other site 862719009548 integral membrane protein MviN; Region: mviN; TIGR01695 862719009549 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 862719009550 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719009551 homodimer interface [polypeptide binding]; other site 862719009552 substrate-cofactor binding pocket; other site 862719009553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009554 catalytic residue [active] 862719009555 Cation efflux family; Region: Cation_efflux; cl00316 862719009556 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 862719009557 OsmC-like protein; Region: OsmC; cl00767 862719009558 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 862719009559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719009560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719009561 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719009562 Sel1 repeat; Region: Sel1; cl02723 862719009563 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 862719009564 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719009565 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719009566 catalytic residue [active] 862719009567 bZIP transcription factor; Region: bZIP_1; cl02576 862719009568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009569 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719009570 Helix-turn-helix domains; Region: HTH; cl00088 862719009571 helicase 45; Provisional; Region: PTZ00424 862719009572 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719009573 ATP binding site [chemical binding]; other site 862719009574 Mg++ binding site [ion binding]; other site 862719009575 motif III; other site 862719009576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719009577 nucleotide binding region [chemical binding]; other site 862719009578 ATP-binding site [chemical binding]; other site 862719009579 Isochorismatase family; Region: Isochorismatase; pfam00857 862719009580 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 862719009581 catalytic triad [active] 862719009582 dimer interface [polypeptide binding]; other site 862719009583 conserved cis-peptide bond; other site 862719009584 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 862719009585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719009586 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 862719009587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009588 Mg2+ binding site [ion binding]; other site 862719009589 G-X-G motif; other site 862719009590 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862719009591 anchoring element; other site 862719009592 dimer interface [polypeptide binding]; other site 862719009593 ATP binding site [chemical binding]; other site 862719009594 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862719009595 active site 862719009596 putative metal-binding site [ion binding]; other site 862719009597 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862719009598 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 862719009599 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719009600 NMT1/THI5 like; Region: NMT1; pfam09084 862719009601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 862719009602 substrate binding pocket [chemical binding]; other site 862719009603 membrane-bound complex binding site; other site 862719009604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719009605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719009606 dimer interface [polypeptide binding]; other site 862719009607 conserved gate region; other site 862719009608 putative PBP binding loops; other site 862719009609 ABC-ATPase subunit interface; other site 862719009610 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719009611 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719009612 Walker A/P-loop; other site 862719009613 ATP binding site [chemical binding]; other site 862719009614 Q-loop/lid; other site 862719009615 ABC transporter signature motif; other site 862719009616 Walker B; other site 862719009617 D-loop; other site 862719009618 H-loop/switch region; other site 862719009619 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862719009620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719009621 Walker A motif; other site 862719009622 ATP binding site [chemical binding]; other site 862719009623 Walker B motif; other site 862719009624 arginine finger; other site 862719009625 Peptidase family M41; Region: Peptidase_M41; pfam01434 862719009626 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862719009627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719009628 substrate binding pocket [chemical binding]; other site 862719009629 membrane-bound complex binding site; other site 862719009630 hinge residues; other site 862719009631 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719009632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719009633 dimerization interface [polypeptide binding]; other site 862719009634 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 862719009635 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719009636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009638 active site 862719009639 phosphorylation site [posttranslational modification] 862719009640 intermolecular recognition site; other site 862719009641 dimerization interface [polypeptide binding]; other site 862719009642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719009643 DNA binding site [nucleotide binding] 862719009644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009646 ATP binding site [chemical binding]; other site 862719009647 Mg2+ binding site [ion binding]; other site 862719009648 G-X-G motif; other site 862719009649 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 862719009650 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719009651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719009652 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719009653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009655 dimer interface [polypeptide binding]; other site 862719009656 phosphorylation site [posttranslational modification] 862719009657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009658 ATP binding site [chemical binding]; other site 862719009659 Mg2+ binding site [ion binding]; other site 862719009660 G-X-G motif; other site 862719009661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719009662 Histidine kinase; Region: HisKA_2; cl06527 862719009663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009664 ATP binding site [chemical binding]; other site 862719009665 Mg2+ binding site [ion binding]; other site 862719009666 G-X-G motif; other site 862719009667 Transposase domain (DUF772); Region: DUF772; cl15789 862719009668 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719009669 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 862719009670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719009671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719009672 ligand binding site [chemical binding]; other site 862719009673 flexible hinge region; other site 862719009674 Helix-turn-helix domains; Region: HTH; cl00088 862719009675 Protein of unknown function (DUF502); Region: DUF502; cl01107 862719009676 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 862719009677 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 862719009678 generic binding surface II; other site 862719009679 ssDNA binding site; other site 862719009680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719009681 ATP binding site [chemical binding]; other site 862719009682 putative Mg++ binding site [ion binding]; other site 862719009683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719009684 nucleotide binding region [chemical binding]; other site 862719009685 ATP-binding site [chemical binding]; other site 862719009686 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719009687 putative binding surface; other site 862719009688 active site 862719009689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009690 ATP binding site [chemical binding]; other site 862719009691 Mg2+ binding site [ion binding]; other site 862719009692 G-X-G motif; other site 862719009693 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719009694 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009696 active site 862719009697 phosphorylation site [posttranslational modification] 862719009698 intermolecular recognition site; other site 862719009699 dimerization interface [polypeptide binding]; other site 862719009700 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719009701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009702 active site 862719009703 phosphorylation site [posttranslational modification] 862719009704 intermolecular recognition site; other site 862719009705 CheB methylesterase; Region: CheB_methylest; pfam01339 862719009706 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719009707 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719009708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009709 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009710 dimer interface [polypeptide binding]; other site 862719009711 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009712 putative CheW interface [polypeptide binding]; other site 862719009713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719009714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009715 dimer interface [polypeptide binding]; other site 862719009716 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009717 putative CheW interface [polypeptide binding]; other site 862719009718 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719009719 YceG-like family; Region: YceG; pfam02618 862719009720 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 862719009721 dimerization interface [polypeptide binding]; other site 862719009722 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 862719009723 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 862719009724 dimer interface [polypeptide binding]; other site 862719009725 active site 862719009726 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719009727 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719009728 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 862719009729 NAD(P) binding site [chemical binding]; other site 862719009730 homotetramer interface [polypeptide binding]; other site 862719009731 homodimer interface [polypeptide binding]; other site 862719009732 active site 862719009733 Acyl transferase domain; Region: Acyl_transf_1; cl08282 862719009734 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719009735 Acyltransferase family; Region: Acyl_transf_3; pfam01757 862719009736 OpgC protein; Region: OpgC_C; cl00792 862719009737 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 862719009738 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 862719009739 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 862719009740 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 862719009741 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 862719009742 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 862719009743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009744 S-adenosylmethionine binding site [chemical binding]; other site 862719009745 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 862719009746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009747 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 862719009748 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 862719009749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719009750 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 862719009751 GcrA cell cycle regulator; Region: GcrA; cl11564 862719009752 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719009753 Putative zinc-finger; Region: zf-HC2; cl15806 862719009754 RNA polymerase sigma factor; Provisional; Region: PRK11924 862719009755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719009756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719009757 DNA binding residues [nucleotide binding] 862719009758 isocitrate dehydrogenase; Validated; Region: PRK09222 862719009759 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 862719009760 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009761 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719009762 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719009763 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719009764 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 862719009765 DNA-binding interface [nucleotide binding]; DNA binding site 862719009766 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719009767 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862719009768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719009769 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719009770 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719009771 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719009772 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9737855; Product type e : enzyme 862719009773 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 862719009774 PII uridylyl-transferase; Provisional; Region: PRK05092 862719009775 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719009776 metal binding triad; other site 862719009777 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 862719009778 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719009779 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 862719009780 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 862719009781 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719009782 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719009783 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 862719009784 putative active site [active] 862719009785 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 862719009786 Sporulation related domain; Region: SPOR; cl10051 862719009787 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 862719009788 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719009789 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 862719009790 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 862719009791 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 862719009792 TMP-binding site; other site 862719009793 ATP-binding site [chemical binding]; other site 862719009794 DNA polymerase III subunit delta'; Validated; Region: PRK07471 862719009795 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 862719009796 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 862719009797 active site 862719009798 HIGH motif; other site 862719009799 KMSKS motif; other site 862719009800 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 862719009801 tRNA binding surface [nucleotide binding]; other site 862719009802 anticodon binding site; other site 862719009803 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 862719009804 active site 862719009805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719009806 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719009807 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719009808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009809 PAS fold; Region: PAS_3; pfam08447 862719009810 putative active site [active] 862719009811 heme pocket [chemical binding]; other site 862719009812 PAS fold; Region: PAS_3; pfam08447 862719009813 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719009814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719009815 metal binding site [ion binding]; metal-binding site 862719009816 active site 862719009817 I-site; other site 862719009818 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719009819 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 862719009820 Recombination protein O N terminal; Region: RecO_N; cl15812 862719009821 Recombination protein O C terminal; Region: RecO_C; pfam02565 862719009822 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 862719009823 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 862719009824 CAP-like domain; other site 862719009825 active site 862719009826 primary dimer interface [polypeptide binding]; other site 862719009827 MgtE intracellular N domain; Region: MgtE_N; cl15244 862719009828 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 862719009829 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719009830 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719009831 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 862719009832 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719009833 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719009834 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 862719009835 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719009836 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 862719009837 SAF domain; Region: SAF; cl00555 862719009838 Flagellar L-ring protein; Region: FlgH; cl00905 862719009839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719009840 non-specific DNA binding site [nucleotide binding]; other site 862719009841 salt bridge; other site 862719009842 sequence-specific DNA binding site [nucleotide binding]; other site 862719009843 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719009844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719009845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719009846 substrate binding pocket [chemical binding]; other site 862719009847 membrane-bound complex binding site; other site 862719009848 hinge residues; other site 862719009849 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 862719009850 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719009851 catalytic residue [active] 862719009852 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719009853 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 862719009854 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719009855 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719009856 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719009857 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 862719009858 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719009859 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 862719009860 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 862719009861 replicative DNA helicase; Provisional; Region: PRK09165 862719009862 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862719009863 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862719009864 Walker A motif; other site 862719009865 ATP binding site [chemical binding]; other site 862719009866 Walker B motif; other site 862719009867 DNA binding loops [nucleotide binding] 862719009868 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719009869 Protein of unknown function (DUF497); Region: DUF497; cl01108 862719009870 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 862719009871 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719009872 integrase; Provisional; Region: int; PHA02601 862719009873 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 862719009874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719009875 active site 862719009876 DNA binding site [nucleotide binding] 862719009877 Int/Topo IB signature motif; other site 862719009878 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 862719009879 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 862719009880 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719009881 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 862719009882 Class II flagellar assembly regulator; Region: FliX; cl11677 862719009883 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 862719009884 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 862719009885 Rod binding protein; Region: Rod-binding; cl01626 862719009886 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 862719009887 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719009888 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719009889 FlgD Ig-like domain; Region: FlgD_ig; cl15790 862719009890 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 862719009891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719009892 Helix-turn-helix domains; Region: HTH; cl00088 862719009893 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 862719009894 putative active site [active] 862719009895 putative catalytic site [active] 862719009896 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719009897 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719009898 Rhomboid family; Region: Rhomboid; cl11446 862719009899 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719009900 enoyl-CoA hydratase; Provisional; Region: PRK07511 862719009901 substrate binding site [chemical binding]; other site 862719009902 oxyanion hole (OAH) forming residues; other site 862719009903 trimer interface [polypeptide binding]; other site 862719009904 PAS domain; Region: PAS_9; pfam13426 862719009905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009906 PAS domain; Region: PAS_9; pfam13426 862719009907 putative active site [active] 862719009908 heme pocket [chemical binding]; other site 862719009909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009910 dimer interface [polypeptide binding]; other site 862719009911 putative CheW interface [polypeptide binding]; other site 862719009912 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 862719009913 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 862719009914 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 862719009915 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 862719009916 active site 862719009917 interdomain interaction site; other site 862719009918 putative metal-binding site [ion binding]; other site 862719009919 nucleotide binding site [chemical binding]; other site 862719009920 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862719009921 domain I; other site 862719009922 DNA binding groove [nucleotide binding] 862719009923 phosphate binding site [ion binding]; other site 862719009924 domain II; other site 862719009925 domain III; other site 862719009926 nucleotide binding site [chemical binding]; other site 862719009927 catalytic site [active] 862719009928 domain IV; other site 862719009929 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862719009930 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 862719009931 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 862719009932 enoyl-CoA hydratase; Validated; Region: PRK08139 862719009933 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719009934 substrate binding site [chemical binding]; other site 862719009935 oxyanion hole (OAH) forming residues; other site 862719009936 trimer interface [polypeptide binding]; other site 862719009937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009938 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 862719009939 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719009940 homodimer interface [polypeptide binding]; other site 862719009941 substrate-cofactor binding pocket; other site 862719009942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009943 catalytic residue [active] 862719009944 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 862719009945 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719009946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719009947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719009948 RF-1 domain; Region: RF-1; cl02875 862719009949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009950 S-adenosylmethionine binding site [chemical binding]; other site 862719009951 AzlC protein; Region: AzlC; cl00570 862719009952 Cupin domain; Region: Cupin_2; cl09118 862719009953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719009954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719009955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719009956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009957 TPR motif; other site 862719009958 binding surface 862719009959 TPR repeat; Region: TPR_11; pfam13414 862719009960 TPR repeat; Region: TPR_11; pfam13414 862719009961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009962 binding surface 862719009963 TPR motif; other site 862719009964 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 862719009965 Predicted GTPase, probable translation factor [Translation, ribosomal structure and biogenesis]; Region: COG0012 862719009966 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862719009967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719009968 ATP binding site [chemical binding]; other site 862719009969 putative Mg++ binding site [ion binding]; other site 862719009970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719009971 nucleotide binding region [chemical binding]; other site 862719009972 ATP-binding site [chemical binding]; other site 862719009973 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 862719009974 active site 862719009975 response regulator PleD; Reviewed; Region: pleD; PRK09581 862719009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009977 active site 862719009978 phosphorylation site [posttranslational modification] 862719009979 intermolecular recognition site; other site 862719009980 dimerization interface [polypeptide binding]; other site 862719009981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009982 active site 862719009983 phosphorylation site [posttranslational modification] 862719009984 intermolecular recognition site; other site 862719009985 dimerization interface [polypeptide binding]; other site 862719009986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719009987 metal binding site [ion binding]; metal-binding site 862719009988 active site 862719009989 I-site; other site 862719009990 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009992 active site 862719009993 phosphorylation site [posttranslational modification] 862719009994 intermolecular recognition site; other site 862719009995 dimerization interface [polypeptide binding]; other site 862719009996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719009997 metal binding site [ion binding]; metal-binding site 862719009998 active site 862719009999 I-site; other site 862719010000 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719010001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010002 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 862719010003 recombination factor protein RarA; Reviewed; Region: PRK13342 862719010004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010005 Walker A motif; other site 862719010006 ATP binding site [chemical binding]; other site 862719010007 Walker B motif; other site 862719010008 arginine finger; other site 862719010009 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 862719010010 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719010011 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 862719010012 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 862719010013 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 862719010014 alphaNTD - beta interaction site [polypeptide binding]; other site 862719010015 alphaNTD homodimer interface [polypeptide binding]; other site 862719010016 alphaNTD - beta' interaction site [polypeptide binding]; other site 862719010017 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 862719010018 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 862719010019 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 862719010020 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 862719010021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719010022 TPR motif; other site 862719010023 TPR repeat; Region: TPR_11; pfam13414 862719010024 binding surface 862719010025 elongation factor G; Reviewed; Region: PRK00007 862719010026 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862719010027 G1 box; other site 862719010028 putative GEF interaction site [polypeptide binding]; other site 862719010029 GTP/Mg2+ binding site [chemical binding]; other site 862719010030 Switch I region; other site 862719010031 G2 box; other site 862719010032 G3 box; other site 862719010033 Switch II region; other site 862719010034 G4 box; other site 862719010035 G5 box; other site 862719010036 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719010037 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862719010038 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719010039 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719010040 homotrimer interaction site [polypeptide binding]; other site 862719010041 putative active site [active] 862719010042 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719010043 DNA topoisomerase III; Provisional; Region: PRK07726 862719010044 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 862719010045 active site 862719010046 interdomain interaction site; other site 862719010047 putative metal-binding site [ion binding]; other site 862719010048 nucleotide binding site [chemical binding]; other site 862719010049 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862719010050 domain I; other site 862719010051 DNA binding groove [nucleotide binding] 862719010052 phosphate binding site [ion binding]; other site 862719010053 domain II; other site 862719010054 domain III; other site 862719010055 nucleotide binding site [chemical binding]; other site 862719010056 catalytic site [active] 862719010057 domain IV; other site 862719010058 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719010059 IHF dimer interface [polypeptide binding]; other site 862719010060 IHF - DNA interface [nucleotide binding]; other site 862719010061 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862719010062 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862719010063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010064 Walker A motif; other site 862719010065 ATP binding site [chemical binding]; other site 862719010066 Walker B motif; other site 862719010067 arginine finger; other site 862719010068 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 862719010069 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 862719010070 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 862719010071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010073 Walker A motif; other site 862719010074 ATP binding site [chemical binding]; other site 862719010075 Walker B motif; other site 862719010076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719010077 Clp protease; Region: CLP_protease; pfam00574 862719010078 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 862719010079 oligomer interface [polypeptide binding]; other site 862719010080 active site residues [active] 862719010081 trigger factor; Provisional; Region: tig; PRK01490 862719010082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 862719010083 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 862719010084 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 862719010085 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 862719010086 putative carbohydrate kinase; Provisional; Region: PRK10565 862719010087 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 862719010088 putative substrate binding site [chemical binding]; other site 862719010089 putative ATP binding site [chemical binding]; other site 862719010090 Nitrogen regulatory protein P-II; Region: P-II; cl00412 862719010091 Nitrogen regulatory protein P-II; Region: P-II; smart00938 862719010092 glutamine synthetase; Provisional; Region: glnA; PRK09469 862719010093 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 862719010094 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 862719010095 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719010096 Amidase; Region: Amidase; cl11426 862719010097 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 862719010098 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719010099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719010100 Coenzyme A binding pocket [chemical binding]; other site 862719010101 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 862719010102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719010103 binding surface 862719010104 TPR motif; other site 862719010105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719010106 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719010107 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719010108 Thymidylate synthase complementing protein; Region: Thy1; cl03630 862719010109 Stringent starvation protein B; Region: SspB; cl01120 862719010110 TfoX N-terminal domain; Region: TfoX_N; cl01167 862719010111 Helix-turn-helix domains; Region: HTH; cl00088 862719010112 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862719010113 active site 862719010114 catalytic residues [active] 862719010115 metal binding site [ion binding]; metal-binding site 862719010116 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 862719010117 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 862719010118 oligomerization interface [polypeptide binding]; other site 862719010119 active site 862719010120 metal binding site [ion binding]; metal-binding site 862719010121 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 862719010122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719010123 ATP binding site [chemical binding]; other site 862719010124 putative Mg++ binding site [ion binding]; other site 862719010125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719010126 nucleotide binding region [chemical binding]; other site 862719010127 ATP-binding site [chemical binding]; other site 862719010128 DEAD/H associated; Region: DEAD_assoc; pfam08494 862719010129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719010130 catalytic loop [active] 862719010131 iron binding site [ion binding]; other site 862719010132 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 862719010133 putative active site [active] 862719010134 putative metal binding site [ion binding]; other site 862719010135 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 862719010136 DNA photolyase; Region: DNA_photolyase; pfam00875 862719010137 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 862719010138 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719010139 metal binding site 2 [ion binding]; metal-binding site 862719010140 putative DNA binding helix; other site 862719010141 metal binding site 1 [ion binding]; metal-binding site 862719010142 dimer interface [polypeptide binding]; other site 862719010143 structural Zn2+ binding site [ion binding]; other site 862719010144 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 862719010145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010146 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 862719010147 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 862719010148 Zn binding site [ion binding]; other site 862719010149 Cache domain; Region: Cache_2; cl07034 862719010150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010151 dimer interface [polypeptide binding]; other site 862719010152 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719010153 putative CheW interface [polypeptide binding]; other site 862719010154 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 862719010155 putative active site pocket [active] 862719010156 dimerization interface [polypeptide binding]; other site 862719010157 putative catalytic residue [active] 862719010158 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 862719010159 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 862719010160 TIGR03442 family protein; Region: TIGR03442 862719010161 putative dimer interface [polypeptide binding]; other site 862719010162 putative active site [active] 862719010163 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010165 active site 862719010166 phosphorylation site [posttranslational modification] 862719010167 intermolecular recognition site; other site 862719010168 dimerization interface [polypeptide binding]; other site 862719010169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010170 dimer interface [polypeptide binding]; other site 862719010171 phosphorylation site [posttranslational modification] 862719010172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010173 ATP binding site [chemical binding]; other site 862719010174 Mg2+ binding site [ion binding]; other site 862719010175 G-X-G motif; other site 862719010176 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 862719010177 multifunctional aminopeptidase A; Provisional; Region: PRK00913 862719010178 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862719010179 interface (dimer of trimers) [polypeptide binding]; other site 862719010180 Substrate-binding/catalytic site; other site 862719010181 Zn-binding sites [ion binding]; other site 862719010182 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 862719010183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719010184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010185 S-adenosylmethionine binding site [chemical binding]; other site 862719010186 MltA specific insert domain; Region: MltA; cl08398 862719010187 3D domain; Region: 3D; cl01439 862719010188 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719010189 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862719010190 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719010191 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 862719010192 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 862719010193 Walker A/P-loop; other site 862719010194 ATP binding site [chemical binding]; other site 862719010195 Q-loop/lid; other site 862719010196 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 862719010197 ABC transporter signature motif; other site 862719010198 Walker B; other site 862719010199 D-loop; other site 862719010200 H-loop/switch region; other site 862719010201 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 862719010202 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719010203 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 862719010204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010205 active site 862719010206 phosphorylation site [posttranslational modification] 862719010207 intermolecular recognition site; other site 862719010208 dimerization interface [polypeptide binding]; other site 862719010209 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 862719010210 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 862719010211 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 862719010212 active site 862719010213 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 862719010214 putative metal binding site [ion binding]; other site 862719010215 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 862719010216 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 862719010217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010218 S-adenosylmethionine binding site [chemical binding]; other site 862719010219 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 862719010220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010221 Family description; Region: UvrD_C_2; cl15862 862719010222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719010223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010224 active site 862719010225 phosphorylation site [posttranslational modification] 862719010226 intermolecular recognition site; other site 862719010227 dimerization interface [polypeptide binding]; other site 862719010228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719010229 DNA binding residues [nucleotide binding] 862719010230 dimerization interface [polypeptide binding]; other site 862719010231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719010232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010233 active site 862719010234 phosphorylation site [posttranslational modification] 862719010235 intermolecular recognition site; other site 862719010236 dimerization interface [polypeptide binding]; other site 862719010237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719010238 DNA binding residues [nucleotide binding] 862719010239 dimerization interface [polypeptide binding]; other site 862719010240 hypothetical protein; Provisional; Region: PRK11770 862719010241 Domain of unknown function (DUF307); Region: DUF307; pfam03733 862719010242 Domain of unknown function (DUF307); Region: DUF307; pfam03733 862719010243 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 862719010244 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 862719010245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010246 ATP binding site [chemical binding]; other site 862719010247 Mg2+ binding site [ion binding]; other site 862719010248 G-X-G motif; other site 862719010249 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 862719010250 ATP binding site [chemical binding]; other site 862719010251 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 862719010252 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 862719010253 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 862719010254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719010255 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 862719010256 NADH(P)-binding; Region: NAD_binding_10; pfam13460 862719010257 NAD binding site [chemical binding]; other site 862719010258 putative active site [active] 862719010259 substrate binding site [chemical binding]; other site 862719010260 Helix-turn-helix domains; Region: HTH; cl00088 862719010261 trehalose synthase; Region: treS_nterm; TIGR02456 862719010262 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 862719010263 active site 862719010264 catalytic site [active] 862719010265 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 862719010266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719010267 putative substrate translocation pore; other site 862719010268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010269 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 862719010270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719010271 RNA binding surface [nucleotide binding]; other site 862719010272 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 862719010273 active site 862719010274 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 862719010275 nucleoside/Zn binding site; other site 862719010276 dimer interface [polypeptide binding]; other site 862719010277 catalytic motif [active] 862719010278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010279 putative active site [active] 862719010280 heme pocket [chemical binding]; other site 862719010281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010282 putative active site [active] 862719010283 heme pocket [chemical binding]; other site 862719010284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010285 dimer interface [polypeptide binding]; other site 862719010286 putative CheW interface [polypeptide binding]; other site 862719010287 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719010288 active site 862719010289 NTP binding site [chemical binding]; other site 862719010290 metal binding triad [ion binding]; metal-binding site 862719010291 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 862719010292 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 862719010293 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719010294 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 862719010295 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 862719010296 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 862719010297 generic binding surface II; other site 862719010298 generic binding surface I; other site 862719010299 tricarballylate dehydrogenase; Validated; Region: PRK08274 862719010300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010301 tricarballylate utilization protein B; Provisional; Region: PRK15033 862719010302 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 862719010303 active site 862719010304 substrate binding pocket [chemical binding]; other site 862719010305 dimer interface [polypeptide binding]; other site 862719010306 histidyl-tRNA synthetase; Region: hisS; TIGR00442 862719010307 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 862719010308 dimer interface [polypeptide binding]; other site 862719010309 motif 1; other site 862719010310 active site 862719010311 motif 2; other site 862719010312 motif 3; other site 862719010313 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 862719010314 anticodon binding site; other site 862719010315 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 862719010316 Transglycosylase; Region: Transgly; cl07896 862719010317 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719010318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010319 NAD(P) binding site [chemical binding]; other site 862719010320 active site 862719010321 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 862719010322 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 862719010323 5S rRNA interface [nucleotide binding]; other site 862719010324 CTC domain interface [polypeptide binding]; other site 862719010325 L16 interface [polypeptide binding]; other site 862719010326 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 862719010327 putative active site [active] 862719010328 catalytic residue [active] 862719010329 GTP-binding protein YchF; Reviewed; Region: PRK09601 862719010330 YchF GTPase; Region: YchF; cd01900 862719010331 G1 box; other site 862719010332 GTP/Mg2+ binding site [chemical binding]; other site 862719010333 Switch I region; other site 862719010334 G2 box; other site 862719010335 Switch II region; other site 862719010336 G3 box; other site 862719010337 G4 box; other site 862719010338 G5 box; other site 862719010339 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 862719010340 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 862719010341 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 862719010342 PhoU domain; Region: PhoU; pfam01895 862719010343 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1689546, 17322315, 15289546; Product type pe : putative enzyme 862719010344 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 862719010345 nudix motif; other site 862719010346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719010347 Helix-turn-helix domains; Region: HTH; cl00088 862719010348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719010349 dimerization interface [polypeptide binding]; other site 862719010350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719010351 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 862719010352 mce related protein; Region: MCE; pfam02470 862719010353 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 862719010354 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 862719010355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719010356 serine O-acetyltransferase; Region: cysE; TIGR01172 862719010357 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719010358 trimer interface [polypeptide binding]; other site 862719010359 active site 862719010360 substrate binding site [chemical binding]; other site 862719010361 CoA binding site [chemical binding]; other site 862719010362 Helix-turn-helix domains; Region: HTH; cl00088 862719010363 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719010364 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719010365 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 862719010366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719010367 catalytic residue [active] 862719010368 Double zinc ribbon; Region: DZR; pfam12773 862719010369 co-chaperone HscB; Provisional; Region: hscB; PRK05014 862719010370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719010371 catalytic loop [active] 862719010372 iron binding site [ion binding]; other site 862719010373 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 862719010374 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 862719010375 Ligand Binding Site [chemical binding]; other site 862719010376 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 862719010377 active site 862719010378 catalytic triad [active] 862719010379 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719010380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010381 Walker A motif; other site 862719010382 ATP binding site [chemical binding]; other site 862719010383 Walker B motif; other site 862719010384 arginine finger; other site 862719010385 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 862719010386 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 862719010387 ParB-like nuclease domain; Region: ParBc; cl02129 862719010388 plasmid partitioning protein; Provisional; Region: PRK13832 862719010389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010392 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 862719010393 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 862719010394 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 862719010395 Protein of unknown function (DUF736); Region: DUF736; cl02303 862719010396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719010397 non-specific DNA binding site [nucleotide binding]; other site 862719010398 salt bridge; other site 862719010399 sequence-specific DNA binding site [nucleotide binding]; other site 862719010400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719010401 sequence-specific DNA binding site [nucleotide binding]; other site 862719010402 salt bridge; other site 862719010403 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 862719010404 Evidence 7 : Gene remnant; Product type e : enzyme 862719010405 Evidence 7 : Gene remnant; Product type e : enzyme 862719010406 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719010407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010408 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 862719010409 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719010410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010411 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 862719010412 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 862719010413 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 862719010414 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 862719010415 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 862719010416 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719010417 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 862719010418 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 862719010419 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719010420 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719010421 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862719010422 Replication initiator protein A; Region: RPA; cl02339 862719010423 ParA-like protein; Provisional; Region: PHA02518 862719010424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719010425 P-loop; other site 862719010426 Magnesium ion binding site [ion binding]; other site 862719010427 Evidence 2b : Function of strongly homologous gene; PubMedId : 11976307; Product type f : factor 862719010428 Evidence 2b : Function of strongly homologous gene; PubMedId : 11976307; Product type f : factor 862719010429 Type II/IV secretion system protein; Region: T2SE; pfam00437 862719010430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010431 Walker A motif; other site 862719010432 ATP binding site [chemical binding]; other site 862719010433 Walker B motif; other site 862719010434 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 862719010435 conjugal transfer protein TrbL; Provisional; Region: PRK13875 862719010436 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 862719010437 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719010438 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719010439 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719010440 VirB7 interaction site; other site 862719010441 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 862719010442 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719010443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010444 ATP binding site [chemical binding]; other site 862719010445 Mg2+ binding site [ion binding]; other site 862719010446 G-X-G motif; other site 862719010447 2,3-oxidosqualene cyclase; Region: osq_cycl; TIGR03463 862719010448 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 862719010449 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 862719010450 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 862719010451 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 862719010452 HTH-like domain; Region: HTH_21; pfam13276 862719010453 Integrase core domain; Region: rve; cl01316 862719010454 Integrase core domain; Region: rve_3; cl15866 862719010455 Helix-turn-helix domains; Region: HTH; cl00088 862719010456 TPR repeat; Region: TPR_11; pfam13414 862719010457 TPR repeat; Region: TPR_11; pfam13414 862719010458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010459 Walker A/P-loop; other site 862719010460 ATP binding site [chemical binding]; other site 862719010461 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 862719010462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719010463 ATP binding site [chemical binding]; other site 862719010464 putative Mg++ binding site [ion binding]; other site 862719010465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719010466 nucleotide binding region [chemical binding]; other site 862719010467 ATP-binding site [chemical binding]; other site 862719010468 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 862719010469 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 862719010470 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 862719010471 HsdM N-terminal domain; Region: HsdM_N; pfam12161 862719010472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010473 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719010474 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719010475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719010477 FeS/SAM binding site; other site 862719010478 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 862719010479 Ferritin-like; Region: Ferritin-like; pfam12902 862719010480 integrase; Provisional; Region: PRK09692 862719010481 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 862719010482 active site 862719010483 Int/Topo IB signature motif; other site 862719010484 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719010485 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719010486 catalytic residues [active] 862719010487 catalytic nucleophile [active] 862719010488 Recombinase; Region: Recombinase; pfam07508 862719010489 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719010490 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719010491 Winged helix-turn helix; Region: HTH_29; pfam13551 862719010492 Helix-turn-helix domains; Region: HTH; cl00088 862719010493 Winged helix-turn helix; Region: HTH_33; pfam13592 862719010494 Helix-turn-helix domains; Region: HTH; cl00088 862719010495 DNA-binding interface [nucleotide binding]; DNA binding site 862719010496 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 862719010497 catalytic residues [active] 862719010498 catalytic nucleophile [active] 862719010499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010500 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 862719010501 Protein of unknown function DUF262; Region: DUF262; cl14890 862719010502 Protein of unknown function DUF262; Region: DUF262; cl14890 862719010503 Protein of unknown function DUF262; Region: DUF262; cl14890 862719010504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010505 EcsC protein family; Region: EcsC; pfam12787 862719010506 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 862719010507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010508 Family description; Region: UvrD_C_2; cl15862 862719010509 Transposase domain (DUF772); Region: DUF772; cl15789 862719010510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010511 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719010512 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719010513 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719010514 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719010515 short chain dehydrogenase; Provisional; Region: PRK06179 862719010516 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 862719010517 NADP binding site [chemical binding]; other site 862719010518 active site 862719010519 steroid binding site; other site 862719010520 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862719010521 MatE; Region: MatE; cl10513 862719010522 MatE; Region: MatE; cl10513 862719010523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719010524 Helix-turn-helix domains; Region: HTH; cl00088 862719010525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719010526 Helix-turn-helix domains; Region: HTH; cl00088 862719010527 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719010528 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719010529 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010531 active site 862719010532 phosphorylation site [posttranslational modification] 862719010533 intermolecular recognition site; other site 862719010534 dimerization interface [polypeptide binding]; other site 862719010535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719010536 metal binding site [ion binding]; metal-binding site 862719010537 active site 862719010538 I-site; other site 862719010539 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 862719010540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010541 Walker A motif; other site 862719010542 ATP binding site [chemical binding]; other site 862719010543 Walker B motif; other site 862719010544 arginine finger; other site 862719010545 Helix-turn-helix domains; Region: HTH; cl00088 862719010546 5-oxoprolinase; Region: PLN02666 862719010547 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719010548 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 862719010549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719010550 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 862719010551 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 862719010552 putative metal binding site [ion binding]; other site 862719010553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719010554 HSP70 interaction site [polypeptide binding]; other site 862719010555 ABC transporter ATPase component; Reviewed; Region: PRK11147 862719010556 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719010557 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862719010558 EamA-like transporter family; Region: EamA; cl01037 862719010559 EamA-like transporter family; Region: EamA; cl01037 862719010560 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 862719010561 amidase catalytic site [active] 862719010562 Zn binding residues [ion binding]; other site 862719010563 substrate binding site [chemical binding]; other site 862719010564 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719010565 putative active site [active] 862719010566 cell division protein MraZ; Reviewed; Region: PRK00326 862719010567 MraZ protein; Region: MraZ; pfam02381 862719010568 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 862719010569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010570 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 862719010571 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 862719010572 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862719010573 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719010574 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 862719010575 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719010576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719010577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719010578 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 862719010579 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719010580 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719010581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719010582 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 862719010583 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 862719010584 Mg++ binding site [ion binding]; other site 862719010585 putative catalytic motif [active] 862719010586 putative substrate binding site [chemical binding]; other site 862719010587 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 862719010588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719010590 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719010591 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 862719010592 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 862719010593 active site 862719010594 homodimer interface [polypeptide binding]; other site 862719010595 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 862719010596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719010597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719010598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719010599 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 862719010600 FAD binding domain; Region: FAD_binding_4; pfam01565 862719010601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 862719010602 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 862719010603 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 862719010604 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719010605 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 862719010606 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 862719010607 Cell division protein FtsQ; Region: FtsQ; pfam03799 862719010608 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 862719010609 Cell division protein FtsA; Region: FtsA; cl11496 862719010610 Cell division protein FtsA; Region: FtsA; cl11496 862719010611 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 862719010612 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 862719010613 nucleotide binding site [chemical binding]; other site 862719010614 SulA interaction site; other site 862719010615 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 862719010616 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 862719010617 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719010618 octamerization interface [polypeptide binding]; other site 862719010619 diferric-oxygen binding site [ion binding]; other site 862719010620 Ligase N family; Region: LIGANc; smart00532 862719010621 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 862719010622 nucleotide binding pocket [chemical binding]; other site 862719010623 K-X-D-G motif; other site 862719010624 catalytic site [active] 862719010625 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 862719010626 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 862719010627 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 862719010628 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 862719010629 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 862719010630 Dimer interface [polypeptide binding]; other site 862719010631 BRCT sequence motif; other site 862719010632 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 862719010633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 862719010634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 862719010635 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 862719010636 active site 862719010637 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 862719010638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719010639 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 862719010640 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719010641 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 862719010642 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 862719010643 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 862719010644 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 862719010645 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 862719010646 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 862719010647 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 862719010648 Sterol carrier protein domain; Region: SCP2_2; pfam13530 862719010649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719010650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010651 dimer interface [polypeptide binding]; other site 862719010652 putative CheW interface [polypeptide binding]; other site 862719010653 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 862719010654 putative active site [active] 862719010655 putative metal binding residues [ion binding]; other site 862719010656 signature motif; other site 862719010657 putative dimer interface [polypeptide binding]; other site 862719010658 putative phosphate binding site [ion binding]; other site 862719010659 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 862719010660 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 862719010661 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719010662 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 862719010663 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719010664 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719010665 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 862719010666 putative ligand binding site [chemical binding]; other site 862719010667 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719010668 TM-ABC transporter signature motif; other site 862719010669 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719010670 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719010671 TM-ABC transporter signature motif; other site 862719010672 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862719010673 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719010674 Walker A/P-loop; other site 862719010675 ATP binding site [chemical binding]; other site 862719010676 Q-loop/lid; other site 862719010677 ABC transporter signature motif; other site 862719010678 Walker B; other site 862719010679 D-loop; other site 862719010680 H-loop/switch region; other site 862719010681 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719010682 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 862719010683 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 862719010684 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 862719010685 ATP12 chaperone protein; Region: ATP12; cl02228 862719010686 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719010687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719010688 motif II; other site 862719010689 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862719010690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719010691 RNA binding surface [nucleotide binding]; other site 862719010692 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 862719010693 active site 862719010694 CrcB-like protein; Region: CRCB; cl09114 862719010695 Isochorismatase family; Region: Isochorismatase; pfam00857 862719010696 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719010697 catalytic triad [active] 862719010698 conserved cis-peptide bond; other site 862719010699 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862719010700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719010701 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719010702 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 862719010703 Walker A/P-loop; other site 862719010704 ATP binding site [chemical binding]; other site 862719010705 Q-loop/lid; other site 862719010706 ABC transporter signature motif; other site 862719010707 Walker B; other site 862719010708 D-loop; other site 862719010709 H-loop/switch region; other site 862719010710 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 862719010711 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719010712 FtsX-like permease family; Region: FtsX; cl15850 862719010713 prolyl-tRNA synthetase; Provisional; Region: PRK12325 862719010714 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 862719010715 dimer interface [polypeptide binding]; other site 862719010716 motif 1; other site 862719010717 active site 862719010718 motif 2; other site 862719010719 motif 3; other site 862719010720 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 862719010721 anticodon binding site; other site 862719010722 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 862719010723 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 862719010724 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719010725 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 862719010726 dimer interface [polypeptide binding]; other site 862719010727 substrate binding site [chemical binding]; other site 862719010728 metal binding site [ion binding]; metal-binding site 862719010729 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862719010730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719010731 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862719010732 Type III pantothenate kinase; Region: Pan_kinase; cl09130 862719010733 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 862719010734 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 862719010735 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 862719010736 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 862719010737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719010738 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 862719010739 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719010740 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 862719010741 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862719010742 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719010743 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 862719010744 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 862719010745 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 862719010746 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 862719010747 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 862719010748 4Fe-4S binding domain; Region: Fer4; cl02805 862719010749 4Fe-4S binding domain; Region: Fer4; cl02805 862719010750 NADH dehydrogenase; Region: NADHdh; cl00469 862719010751 NADH dehydrogenase subunit G; Validated; Region: PRK09130 862719010752 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719010753 catalytic loop [active] 862719010754 iron binding site [ion binding]; other site 862719010755 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 862719010756 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 862719010757 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 862719010758 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 862719010759 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 862719010760 SLBB domain; Region: SLBB; pfam10531 862719010761 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 862719010762 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 862719010763 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 862719010764 putative dimer interface [polypeptide binding]; other site 862719010765 [2Fe-2S] cluster binding site [ion binding]; other site 862719010766 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 862719010767 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 862719010768 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 862719010769 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 862719010770 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 862719010771 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 862719010772 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 862719010773 catalytic residues [active] 862719010774 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 862719010775 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 862719010776 AMP-binding enzyme; Region: AMP-binding; cl15778 862719010777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719010778 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 862719010779 LysE type translocator; Region: LysE; cl00565 862719010780 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 862719010781 Helix-turn-helix domains; Region: HTH; cl00088 862719010782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719010783 dimerization interface [polypeptide binding]; other site 862719010784 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 862719010785 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 862719010786 active site 862719010787 Zn binding site [ion binding]; other site 862719010788 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719010789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010790 S-adenosylmethionine binding site [chemical binding]; other site 862719010791 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 862719010792 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 862719010793 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719010794 PhoU domain; Region: PhoU; pfam01895 862719010795 PhoU domain; Region: PhoU; pfam01895 862719010796 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 862719010797 rod shape-determining protein MreB; Provisional; Region: PRK13927 862719010798 Cell division protein FtsA; Region: FtsA; cl11496 862719010799 rod shape-determining protein MreC; Provisional; Region: PRK13922 862719010800 rod shape-determining protein MreC; Region: MreC; pfam04085 862719010801 rod shape-determining protein MreD; Region: MreD; cl01087 862719010802 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 862719010803 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862719010804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719010805 ketol-acid reductoisomerase; Provisional; Region: PRK05479 862719010806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010807 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 862719010808 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 862719010809 putative active site [active] 862719010810 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719010811 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 862719010812 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 862719010813 putative valine binding site [chemical binding]; other site 862719010814 dimer interface [polypeptide binding]; other site 862719010815 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 862719010816 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 862719010817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719010818 PYR/PP interface [polypeptide binding]; other site 862719010819 dimer interface [polypeptide binding]; other site 862719010820 TPP binding site [chemical binding]; other site 862719010821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 862719010822 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 862719010823 TPP-binding site [chemical binding]; other site 862719010824 dimer interface [polypeptide binding]; other site 862719010825 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 862719010826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719010827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719010828 homodimer interface [polypeptide binding]; other site 862719010829 catalytic residue [active] 862719010830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010831 phosphoserine phosphatase SerB; Region: serB; TIGR00338 862719010832 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719010833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719010834 motif II; other site 862719010835 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719010836 octamerization interface [polypeptide binding]; other site 862719010837 diferric-oxygen binding site [ion binding]; other site 862719010838 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 862719010839 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 862719010840 NAD binding site [chemical binding]; other site 862719010841 homotetramer interface [polypeptide binding]; other site 862719010842 homodimer interface [polypeptide binding]; other site 862719010843 substrate binding site [chemical binding]; other site 862719010844 active site 862719010845 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 862719010846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719010847 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 862719010848 UreF; Region: UreF; pfam01730 862719010849 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 862719010850 dimer interface [polypeptide binding]; other site 862719010851 catalytic residues [active] 862719010852 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719010853 urease subunit alpha; Reviewed; Region: ureC; PRK13207 862719010854 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 862719010855 subunit interactions [polypeptide binding]; other site 862719010856 active site 862719010857 flap region; other site 862719010858 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 862719010859 gamma-beta subunit interface [polypeptide binding]; other site 862719010860 alpha-beta subunit interface [polypeptide binding]; other site 862719010861 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 862719010862 alpha-gamma subunit interface [polypeptide binding]; other site 862719010863 beta-gamma subunit interface [polypeptide binding]; other site 862719010864 UreD urease accessory protein; Region: UreD; cl00530 862719010865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719010866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010867 active site 862719010868 phosphorylation site [posttranslational modification] 862719010869 intermolecular recognition site; other site 862719010870 dimerization interface [polypeptide binding]; other site 862719010871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719010872 DNA binding residues [nucleotide binding] 862719010873 dimerization interface [polypeptide binding]; other site 862719010874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719010875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719010876 active site 862719010877 phosphorylation site [posttranslational modification] 862719010878 intermolecular recognition site; other site 862719010879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719010880 DNA binding residues [nucleotide binding] 862719010881 dimerization interface [polypeptide binding]; other site 862719010882 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 862719010883 intracellular protease, PfpI family; Region: PfpI; TIGR01382 862719010884 proposed catalytic triad [active] 862719010885 conserved cys residue [active] 862719010886 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 862719010887 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 862719010888 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 862719010889 hinge; other site 862719010890 active site 862719010891 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 862719010892 trimer interface [polypeptide binding]; other site 862719010893 active site 862719010894 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719010895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719010896 Coenzyme A binding pocket [chemical binding]; other site 862719010897 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719010898 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 862719010899 putative NAD(P) binding site [chemical binding]; other site 862719010900 active site 862719010901 putative substrate binding site [chemical binding]; other site 862719010902 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 862719010903 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 862719010904 Mg++ binding site [ion binding]; other site 862719010905 putative catalytic motif [active] 862719010906 putative substrate binding site [chemical binding]; other site 862719010907 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719010908 Probable Catalytic site; other site 862719010909 metal-binding site 862719010910 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862719010911 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719010912 Probable Catalytic site; other site 862719010913 metal-binding site 862719010914 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719010915 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 862719010916 putative NAD(P) binding site [chemical binding]; other site 862719010917 active site 862719010918 putative substrate binding site [chemical binding]; other site 862719010919 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 862719010920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010921 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 862719010922 NAD(P) binding site [chemical binding]; other site 862719010923 homodimer interface [polypeptide binding]; other site 862719010924 substrate binding site [chemical binding]; other site 862719010925 active site 862719010926 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 862719010927 Tetramer interface [polypeptide binding]; other site 862719010928 active site 862719010929 FMN-binding site [chemical binding]; other site 862719010930 ribonuclease R; Region: RNase_R; TIGR02063 862719010931 RNB domain; Region: RNB; pfam00773 862719010932 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 862719010933 RNA binding site [nucleotide binding]; other site 862719010934 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862719010935 protein binding site [polypeptide binding]; other site 862719010936 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862719010937 Catalytic dyad [active] 862719010938 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 862719010939 TIGR03440 family protein; Region: unchr_TIGR03440 862719010940 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 862719010941 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862719010942 LrgA family; Region: LrgA; cl00608 862719010943 LrgB-like family; Region: LrgB; cl00596 862719010944 2-isopropylmalate synthase; Validated; Region: PRK03739 862719010945 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 862719010946 active site 862719010947 catalytic residues [active] 862719010948 metal binding site [ion binding]; metal-binding site 862719010949 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 862719010950 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 862719010951 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 862719010952 NADP binding site [chemical binding]; other site 862719010953 homopentamer interface [polypeptide binding]; other site 862719010954 substrate binding site [chemical binding]; other site 862719010955 active site 862719010956 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 862719010957 Uncharacterized conserved protein [Function unknown]; Region: COG1565 862719010958 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 862719010959 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 862719010960 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 862719010961 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 862719010962 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862719010963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719010964 active site 862719010965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719010966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719010967 non-specific DNA binding site [nucleotide binding]; other site 862719010968 salt bridge; other site 862719010969 sequence-specific DNA binding site [nucleotide binding]; other site 862719010970 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719010971 Catalytic site [active] 862719010972 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719010973 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 862719010974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719010975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010976 dimer interface [polypeptide binding]; other site 862719010977 phosphorylation site [posttranslational modification] 862719010978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010979 ATP binding site [chemical binding]; other site 862719010980 Mg2+ binding site [ion binding]; other site 862719010981 G-X-G motif; other site 862719010982 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010984 active site 862719010985 phosphorylation site [posttranslational modification] 862719010986 intermolecular recognition site; other site 862719010987 dimerization interface [polypeptide binding]; other site 862719010988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719010989 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 862719010990 Walker A/P-loop; other site 862719010991 ATP binding site [chemical binding]; other site 862719010992 Q-loop/lid; other site 862719010993 ABC transporter signature motif; other site 862719010994 Walker B; other site 862719010995 D-loop; other site 862719010996 H-loop/switch region; other site 862719010997 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719010998 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 862719010999 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719011000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719011001 Helix-turn-helix domains; Region: HTH; cl00088 862719011002 GAF domain; Region: GAF_2; pfam13185 862719011003 GAF domain; Region: GAF; cl15785 862719011004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011005 Walker A motif; other site 862719011006 ATP binding site [chemical binding]; other site 862719011007 Walker B motif; other site 862719011008 arginine finger; other site 862719011009 Helix-turn-helix domains; Region: HTH; cl00088 862719011010 cyclase homology domain; Region: CHD; cd07302 862719011011 nucleotidyl binding site; other site 862719011012 metal binding site [ion binding]; metal-binding site 862719011013 dimer interface [polypeptide binding]; other site 862719011014 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719011015 phosphopeptide binding site; other site 862719011016 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 862719011017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719011018 FeS/SAM binding site; other site 862719011019 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 862719011020 hypothetical protein; Provisional; Region: PRK13795 862719011021 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 862719011022 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 862719011023 NifZ domain; Region: NifZ; pfam04319 862719011024 NifZ domain; Region: NifZ; pfam04319 862719011025 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719011026 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 862719011027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719011028 catalytic residue [active] 862719011029 NifT/FixU protein; Region: NifT; cl02351 862719011030 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862719011031 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719011032 inhibitor-cofactor binding pocket; inhibition site 862719011033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719011034 catalytic residue [active] 862719011035 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 862719011036 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 862719011037 Intracellular septation protein A; Region: IspA; cl01098 862719011038 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 862719011039 Sporulation related domain; Region: SPOR; cl10051 862719011040 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011042 active site 862719011043 phosphorylation site [posttranslational modification] 862719011044 intermolecular recognition site; other site 862719011045 dimerization interface [polypeptide binding]; other site 862719011046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 862719011047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719011048 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862719011049 active site 862719011050 catalytic site [active] 862719011051 substrate binding site [chemical binding]; other site 862719011052 Sodium:solute symporter family; Region: SSF; cl00456 862719011053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011054 dimer interface [polypeptide binding]; other site 862719011055 phosphorylation site [posttranslational modification] 862719011056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011057 ATP binding site [chemical binding]; other site 862719011058 Mg2+ binding site [ion binding]; other site 862719011059 G-X-G motif; other site 862719011060 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011062 active site 862719011063 phosphorylation site [posttranslational modification] 862719011064 intermolecular recognition site; other site 862719011065 dimerization interface [polypeptide binding]; other site 862719011066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011067 PAS domain; Region: PAS_9; pfam13426 862719011068 putative active site [active] 862719011069 heme pocket [chemical binding]; other site 862719011070 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719011071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011072 ATP binding site [chemical binding]; other site 862719011073 Mg2+ binding site [ion binding]; other site 862719011074 G-X-G motif; other site 862719011075 PAS domain; Region: PAS_9; pfam13426 862719011076 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 862719011077 PAS fold; Region: PAS_7; pfam12860 862719011078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011079 dimer interface [polypeptide binding]; other site 862719011080 phosphorylation site [posttranslational modification] 862719011081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011082 ATP binding site [chemical binding]; other site 862719011083 Mg2+ binding site [ion binding]; other site 862719011084 G-X-G motif; other site 862719011085 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011087 active site 862719011088 phosphorylation site [posttranslational modification] 862719011089 intermolecular recognition site; other site 862719011090 dimerization interface [polypeptide binding]; other site 862719011091 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 862719011092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719011093 active site residue [active] 862719011094 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 862719011095 ATP binding site [chemical binding]; other site 862719011096 substrate interface [chemical binding]; other site 862719011097 Uncharacterized conserved protein [Function unknown]; Region: COG3482 862719011098 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 862719011099 YcaO-like family; Region: YcaO; pfam02624 862719011100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862719011101 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719011102 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 862719011103 dimer interface [polypeptide binding]; other site 862719011104 motif 1; other site 862719011105 active site 862719011106 motif 2; other site 862719011107 motif 3; other site 862719011108 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 862719011109 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719011110 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 862719011111 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 862719011112 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 862719011113 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 862719011114 putative active site [active] 862719011115 catalytic triad [active] 862719011116 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 862719011117 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 862719011118 dimerization interface [polypeptide binding]; other site 862719011119 ATP binding site [chemical binding]; other site 862719011120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 862719011121 dimerization interface [polypeptide binding]; other site 862719011122 ATP binding site [chemical binding]; other site 862719011123 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719011124 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 862719011125 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011127 active site 862719011128 phosphorylation site [posttranslational modification] 862719011129 intermolecular recognition site; other site 862719011130 dimerization interface [polypeptide binding]; other site 862719011131 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 862719011132 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 862719011133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862719011134 active site 862719011135 HIGH motif; other site 862719011136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862719011137 KMSKS motif; other site 862719011138 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719011139 tRNA binding surface [nucleotide binding]; other site 862719011140 anticodon binding site; other site 862719011141 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 862719011142 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719011143 active site 862719011144 HIGH motif; other site 862719011145 nucleotide binding site [chemical binding]; other site 862719011146 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862719011147 active site 862719011148 KMSKS motif; other site 862719011149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719011150 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719011151 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719011152 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 862719011153 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 862719011154 conserved cys residue [active] 862719011155 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862719011156 NAD synthetase; Provisional; Region: PRK13981 862719011157 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 862719011158 active site 862719011159 catalytic triad [active] 862719011160 dimer interface [polypeptide binding]; other site 862719011161 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719011162 Ligand Binding Site [chemical binding]; other site 862719011163 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 862719011164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719011165 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 862719011166 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 862719011167 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 862719011168 Ligand binding site; other site 862719011169 Putative Catalytic site; other site 862719011170 DXD motif; other site 862719011171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011172 dimerization interface [polypeptide binding]; other site 862719011173 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719011174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011175 dimer interface [polypeptide binding]; other site 862719011176 putative CheW interface [polypeptide binding]; other site 862719011177 Protein of unknown function, DUF462; Region: DUF462; cl01190 862719011178 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719011179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719011180 dimerization interface [polypeptide binding]; other site 862719011181 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011182 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011183 dimer interface [polypeptide binding]; other site 862719011184 putative CheW interface [polypeptide binding]; other site 862719011185 Membrane transport protein; Region: Mem_trans; cl09117 862719011186 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 862719011187 Uncharacterized conserved protein [Function unknown]; Region: COG3760 862719011188 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 862719011189 putative deacylase active site [active] 862719011190 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 862719011191 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 862719011192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719011193 binding surface 862719011194 TPR motif; other site 862719011195 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 862719011196 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862719011197 Trm112p-like protein; Region: Trm112p; cl01066 862719011198 Protein of unknown function (DUF971); Region: DUF971; cl01414 862719011199 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 862719011200 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 862719011201 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 862719011202 NAD(P) binding site [chemical binding]; other site 862719011203 homotetramer interface [polypeptide binding]; other site 862719011204 homodimer interface [polypeptide binding]; other site 862719011205 active site 862719011206 putative acyltransferase; Provisional; Region: PRK05790 862719011207 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719011208 dimer interface [polypeptide binding]; other site 862719011209 active site 862719011210 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 862719011211 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 862719011212 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 862719011213 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 862719011214 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 862719011215 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 862719011216 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 862719011217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719011218 S-adenosylmethionine binding site [chemical binding]; other site 862719011219 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 862719011220 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 862719011221 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 862719011222 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719011223 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862719011224 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 862719011225 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719011226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719011227 Walker A/P-loop; other site 862719011228 ATP binding site [chemical binding]; other site 862719011229 Q-loop/lid; other site 862719011230 ABC transporter signature motif; other site 862719011231 Walker B; other site 862719011232 D-loop; other site 862719011233 H-loop/switch region; other site 862719011234 Predicted membrane protein [Function unknown]; Region: COG2311 862719011235 Protein of unknown function (DUF418); Region: DUF418; cl12135 862719011236 Protein of unknown function (DUF418); Region: DUF418; cl12135 862719011237 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 862719011238 Helix-turn-helix domains; Region: HTH; cl00088 862719011239 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 862719011240 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 862719011241 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 862719011242 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 862719011243 putative dimer interface [polypeptide binding]; other site 862719011244 Predicted helicase [General function prediction only]; Region: COG4889 862719011245 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 862719011246 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 862719011247 GTPase CgtA; Reviewed; Region: obgE; PRK12299 862719011248 GTP1/OBG; Region: GTP1_OBG; pfam01018 862719011249 Obg GTPase; Region: Obg; cd01898 862719011250 G1 box; other site 862719011251 GTP/Mg2+ binding site [chemical binding]; other site 862719011252 Switch I region; other site 862719011253 G2 box; other site 862719011254 G3 box; other site 862719011255 Switch II region; other site 862719011256 G4 box; other site 862719011257 G5 box; other site 862719011258 gamma-glutamyl kinase; Provisional; Region: PRK05429 862719011259 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 862719011260 nucleotide binding site [chemical binding]; other site 862719011261 homotetrameric interface [polypeptide binding]; other site 862719011262 putative phosphate binding site [ion binding]; other site 862719011263 putative allosteric binding site; other site 862719011264 PUA domain; Region: PUA; cl00607 862719011265 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 862719011266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719011267 active site 862719011268 motif I; other site 862719011269 motif II; other site 862719011270 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 862719011271 NodB motif; other site 862719011272 putative active site [active] 862719011273 putative catalytic site [active] 862719011274 Zn binding site [ion binding]; other site 862719011275 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 862719011276 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862719011277 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862719011278 protein binding site [polypeptide binding]; other site 862719011279 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862719011280 Catalytic dyad [active] 862719011281 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 862719011282 Sulfatase; Region: Sulfatase; cl10460 862719011283 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 862719011284 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 862719011285 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 862719011286 Oligomerisation domain; Region: Oligomerisation; cl00519 862719011287 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 862719011288 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 862719011289 active site 862719011290 (T/H)XGH motif; other site 862719011291 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 862719011292 putative catalytic cysteine [active] 862719011293 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 862719011294 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719011295 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 862719011296 putative active site [active] 862719011297 Ap4A binding site [chemical binding]; other site 862719011298 nudix motif; other site 862719011299 putative metal binding site [ion binding]; other site 862719011300 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 862719011301 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011303 active site 862719011304 phosphorylation site [posttranslational modification] 862719011305 intermolecular recognition site; other site 862719011306 dimerization interface [polypeptide binding]; other site 862719011307 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 862719011308 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719011309 putative binding surface; other site 862719011310 active site 862719011311 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 862719011312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011313 ATP binding site [chemical binding]; other site 862719011314 Mg2+ binding site [ion binding]; other site 862719011315 G-X-G motif; other site 862719011316 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 862719011317 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 862719011318 putative CheA interaction surface; other site 862719011319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011320 PAS domain; Region: PAS_9; pfam13426 862719011321 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011324 dimer interface [polypeptide binding]; other site 862719011325 putative CheW interface [polypeptide binding]; other site 862719011326 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862719011327 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 862719011328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011329 CheD chemotactic sensory transduction; Region: CheD; cl00810 862719011330 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719011331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011332 active site 862719011333 phosphorylation site [posttranslational modification] 862719011334 intermolecular recognition site; other site 862719011335 dimerization interface [polypeptide binding]; other site 862719011336 CheB methylesterase; Region: CheB_methylest; pfam01339 862719011337 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011339 dimer interface [polypeptide binding]; other site 862719011340 putative CheW interface [polypeptide binding]; other site 862719011341 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719011342 anti sigma factor interaction site; other site 862719011343 regulatory phosphorylation site [posttranslational modification]; other site 862719011344 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 862719011345 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011347 active site 862719011348 phosphorylation site [posttranslational modification] 862719011349 intermolecular recognition site; other site 862719011350 dimerization interface [polypeptide binding]; other site 862719011351 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719011352 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011354 active site 862719011355 phosphorylation site [posttranslational modification] 862719011356 intermolecular recognition site; other site 862719011357 dimerization interface [polypeptide binding]; other site 862719011358 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719011359 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 862719011360 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 862719011361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719011362 RNA binding surface [nucleotide binding]; other site 862719011363 Predicted dehydrogenase [General function prediction only]; Region: COG0579 862719011364 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 862719011365 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 862719011366 putative dimer interface [polypeptide binding]; other site 862719011367 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 862719011368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011369 dimerization interface [polypeptide binding]; other site 862719011370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011372 dimer interface [polypeptide binding]; other site 862719011373 putative CheW interface [polypeptide binding]; other site 862719011374 PilZ domain; Region: PilZ; cl01260 862719011375 RmuC family; Region: RmuC; pfam02646 862719011376 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 862719011377 nudix motif; other site 862719011378 Protein of unknown function, DUF399; Region: DUF399; cl01139 862719011379 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862719011380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719011381 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719011382 classical (c) SDRs; Region: SDR_c; cd05233 862719011383 NAD(P) binding site [chemical binding]; other site 862719011384 active site 862719011385 aspartate aminotransferase; Provisional; Region: PRK05764 862719011386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719011387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719011388 homodimer interface [polypeptide binding]; other site 862719011389 catalytic residue [active] 862719011390 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 862719011391 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 862719011392 Peptidase family M48; Region: Peptidase_M48; cl12018 862719011393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 862719011394 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 862719011395 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862719011396 catalytic residues [active] 862719011397 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 862719011398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719011399 motif II; other site 862719011400 MT-A70; Region: MT-A70; cl01947 862719011401 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719011402 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719011403 ligand binding site [chemical binding]; other site 862719011404 flexible hinge region; other site 862719011405 Helix-turn-helix domains; Region: HTH; cl00088 862719011406 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 862719011407 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719011408 DNA-binding site [nucleotide binding]; DNA binding site 862719011409 RNA-binding motif; other site 862719011410 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719011411 DNA-binding site [nucleotide binding]; DNA binding site 862719011412 RNA-binding motif; other site 862719011413 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 862719011414 FMN binding site [chemical binding]; other site 862719011415 active site 862719011416 substrate binding site [chemical binding]; other site 862719011417 catalytic residue [active] 862719011418 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719011419 catalytic core [active] 862719011420 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 862719011421 putative substrate binding site [chemical binding]; other site 862719011422 putative ATP binding site [chemical binding]; other site 862719011423 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 862719011424 B1 nucleotide binding pocket [chemical binding]; other site 862719011425 B2 nucleotide binding pocket [chemical binding]; other site 862719011426 CAS motifs; other site 862719011427 active site 862719011428 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719011429 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 862719011430 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 862719011431 catalytic triad [active] 862719011432 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 862719011433 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719011434 metal binding triad; other site 862719011435 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 862719011436 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719011437 metal binding triad; other site 862719011438 Protein of unknown function; Region: DUF3971; pfam13116 862719011439 AsmA-like C-terminal region; Region: AsmA_2; cl15864 862719011440 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862719011441 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862719011442 active site 862719011443 HIGH motif; other site 862719011444 dimer interface [polypeptide binding]; other site 862719011445 KMSKS motif; other site 862719011446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719011447 RNA binding surface [nucleotide binding]; other site 862719011448 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 862719011449 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 862719011450 heme binding site [chemical binding]; other site 862719011451 ferroxidase pore; other site 862719011452 ferroxidase diiron center [ion binding]; other site 862719011453 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 862719011454 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 862719011455 heme binding site [chemical binding]; other site 862719011456 ferroxidase pore; other site 862719011457 ferroxidase diiron center [ion binding]; other site 862719011458 AAA domain; Region: AAA_31; pfam13614 862719011459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719011460 P-loop; other site 862719011461 Magnesium ion binding site [ion binding]; other site 862719011462 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 862719011463 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 862719011464 EamA-like transporter family; Region: EamA; cl01037 862719011465 EamA-like transporter family; Region: EamA; cl01037 862719011466 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719011467 FAD binding domain; Region: FAD_binding_4; pfam01565 862719011468 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719011469 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 862719011470 substrate binding site [chemical binding]; other site 862719011471 ligand binding site [chemical binding]; other site 862719011472 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 862719011473 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719011474 TM-ABC transporter signature motif; other site 862719011475 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 862719011476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011477 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862719011478 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 862719011479 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719011480 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719011481 catalytic triad [active] 862719011482 conserved cis-peptide bond; other site 862719011483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719011484 Helix-turn-helix domains; Region: HTH; cl00088 862719011485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719011486 dimerization interface [polypeptide binding]; other site 862719011487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011488 PAS domain S-box; Region: sensory_box; TIGR00229 862719011489 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719011490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011491 dimer interface [polypeptide binding]; other site 862719011492 phosphorylation site [posttranslational modification] 862719011493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011494 ATP binding site [chemical binding]; other site 862719011495 Mg2+ binding site [ion binding]; other site 862719011496 G-X-G motif; other site 862719011497 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011499 active site 862719011500 phosphorylation site [posttranslational modification] 862719011501 intermolecular recognition site; other site 862719011502 dimerization interface [polypeptide binding]; other site 862719011503 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 862719011504 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 862719011505 dimerization interface 3.5A [polypeptide binding]; other site 862719011506 active site 862719011507 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 862719011508 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 862719011509 putative active site [active] 862719011510 substrate binding site [chemical binding]; other site 862719011511 putative cosubstrate binding site; other site 862719011512 catalytic site [active] 862719011513 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 862719011514 substrate binding site [chemical binding]; other site 862719011515 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862719011516 active site 862719011517 catalytic residues [active] 862719011518 metal binding site [ion binding]; metal-binding site 862719011519 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 862719011520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719011521 catalytic core [active] 862719011522 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719011523 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 862719011524 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719011525 ATP binding site [chemical binding]; other site 862719011526 Mg++ binding site [ion binding]; other site 862719011527 motif III; other site 862719011528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719011529 nucleotide binding region [chemical binding]; other site 862719011530 ATP-binding site [chemical binding]; other site 862719011531 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719011532 Winged helix-turn helix; Region: HTH_29; pfam13551 862719011533 Helix-turn-helix domains; Region: HTH; cl00088 862719011534 Winged helix-turn helix; Region: HTH_33; pfam13592 862719011535 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 862719011536 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 862719011537 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 862719011538 active site 862719011539 catalytic residues [active] 862719011540 metal binding site [ion binding]; metal-binding site 862719011541 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 862719011542 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719011543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719011544 dimerization interface [polypeptide binding]; other site 862719011545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011546 dimer interface [polypeptide binding]; other site 862719011547 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719011548 putative CheW interface [polypeptide binding]; other site 862719011549 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 862719011550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011551 tellurite resistance protein terB; Region: terB; cd07176 862719011552 putative metal binding site [ion binding]; other site 862719011553 Membrane transport protein; Region: Mem_trans; cl09117 862719011554 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719011555 metal binding site [ion binding]; metal-binding site 862719011556 active site 862719011557 I-site; other site 862719011558 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719011559 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 862719011560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719011561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719011562 Transglycosylase; Region: Transgly; cl07896 862719011563 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 862719011564 Cupin domain; Region: Cupin_2; cl09118 862719011565 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719011566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719011567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719011568 DNA binding residues [nucleotide binding] 862719011569 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 862719011570 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719011571 dimer interface [polypeptide binding]; other site 862719011572 putative functional site; other site 862719011573 putative MPT binding site; other site 862719011574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719011575 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719011576 dimer interface [polypeptide binding]; other site 862719011577 putative functional site; other site 862719011578 putative MPT binding site; other site 862719011579 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011581 active site 862719011582 phosphorylation site [posttranslational modification] 862719011583 intermolecular recognition site; other site 862719011584 dimerization interface [polypeptide binding]; other site 862719011585 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719011586 metal binding site [ion binding]; metal-binding site 862719011587 active site 862719011588 I-site; other site 862719011589 PAS fold; Region: PAS; pfam00989 862719011590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011591 putative active site [active] 862719011592 heme pocket [chemical binding]; other site 862719011593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011594 dimer interface [polypeptide binding]; other site 862719011595 phosphorylation site [posttranslational modification] 862719011596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011597 ATP binding site [chemical binding]; other site 862719011598 Mg2+ binding site [ion binding]; other site 862719011599 G-X-G motif; other site 862719011600 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011602 active site 862719011603 phosphorylation site [posttranslational modification] 862719011604 intermolecular recognition site; other site 862719011605 dimerization interface [polypeptide binding]; other site 862719011606 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011608 active site 862719011609 phosphorylation site [posttranslational modification] 862719011610 intermolecular recognition site; other site 862719011611 dimerization interface [polypeptide binding]; other site 862719011612 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719011613 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 862719011614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719011615 LytTr DNA-binding domain; Region: LytTR; cl04498 862719011616 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 862719011617 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719011618 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 862719011619 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 862719011620 trimer interface [polypeptide binding]; other site 862719011621 active site 862719011622 UDP-GlcNAc binding site [chemical binding]; other site 862719011623 lipid binding site [chemical binding]; lipid-binding site 862719011624 Cupin domain; Region: Cupin_2; cl09118 862719011625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719011626 ligand binding site [chemical binding]; other site 862719011627 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719011628 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719011629 acetyl-CoA synthetase; Provisional; Region: PRK00174 862719011630 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 862719011631 AMP-binding enzyme; Region: AMP-binding; cl15778 862719011632 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719011633 EVE domain; Region: EVE; cl00728 862719011634 YCII-related domain; Region: YCII; cl00999 862719011635 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 862719011636 active site 862719011637 catalytic site [active] 862719011638 substrate binding site [chemical binding]; other site 862719011639 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719011640 ADP-ribose binding site [chemical binding]; other site 862719011641 dimer interface [polypeptide binding]; other site 862719011642 active site 862719011643 nudix motif; other site 862719011644 metal binding site [ion binding]; metal-binding site 862719011645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719011646 S-adenosylmethionine binding site [chemical binding]; other site 862719011647 aconitate hydratase; Validated; Region: PRK09277 862719011648 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 862719011649 substrate binding site [chemical binding]; other site 862719011650 ligand binding site [chemical binding]; other site 862719011651 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 862719011652 substrate binding site [chemical binding]; other site 862719011653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011654 PAS domain; Region: PAS_9; pfam13426 862719011655 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719011656 PAS fold; Region: PAS_4; pfam08448 862719011657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011658 putative active site [active] 862719011659 heme pocket [chemical binding]; other site 862719011660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719011661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011662 ATP binding site [chemical binding]; other site 862719011663 Mg2+ binding site [ion binding]; other site 862719011664 G-X-G motif; other site 862719011665 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011667 active site 862719011668 phosphorylation site [posttranslational modification] 862719011669 intermolecular recognition site; other site 862719011670 dimerization interface [polypeptide binding]; other site 862719011671 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 862719011672 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 862719011673 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 862719011674 catalytic triad [active] 862719011675 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 862719011676 putative active site [active] 862719011677 catalytic site [active] 862719011678 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 862719011679 phospholipase D alpha; Region: PLN02270 862719011680 putative active site [active] 862719011681 catalytic site [active] 862719011682 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719011683 ligand binding site [chemical binding]; other site 862719011684 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719011685 Phospholipid methyltransferase; Region: PEMT; cl00763 862719011686 FOG: CBS domain [General function prediction only]; Region: COG0517 862719011687 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 862719011688 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719011689 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719011690 DNA-binding site [nucleotide binding]; DNA binding site 862719011691 RNA-binding motif; other site 862719011692 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719011693 DNA-binding site [nucleotide binding]; DNA binding site 862719011694 RNA-binding motif; other site 862719011695 EamA-like transporter family; Region: EamA; cl01037 862719011696 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719011697 PAS domain S-box; Region: sensory_box; TIGR00229 862719011698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011699 putative active site [active] 862719011700 heme pocket [chemical binding]; other site 862719011701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011702 dimer interface [polypeptide binding]; other site 862719011703 phosphorylation site [posttranslational modification] 862719011704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011705 ATP binding site [chemical binding]; other site 862719011706 Mg2+ binding site [ion binding]; other site 862719011707 G-X-G motif; other site 862719011708 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011710 active site 862719011711 phosphorylation site [posttranslational modification] 862719011712 intermolecular recognition site; other site 862719011713 dimerization interface [polypeptide binding]; other site 862719011714 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719011715 putative binding surface; other site 862719011716 active site 862719011717 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 862719011718 maleylacetoacetate isomerase; Region: maiA; TIGR01262 862719011719 C-terminal domain interface [polypeptide binding]; other site 862719011720 GSH binding site (G-site) [chemical binding]; other site 862719011721 putative dimer interface [polypeptide binding]; other site 862719011722 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 862719011723 dimer interface [polypeptide binding]; other site 862719011724 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 862719011725 N-terminal domain interface [polypeptide binding]; other site 862719011726 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719011727 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719011728 Walker A/P-loop; other site 862719011729 ATP binding site [chemical binding]; other site 862719011730 Q-loop/lid; other site 862719011731 ABC transporter signature motif; other site 862719011732 Walker B; other site 862719011733 D-loop; other site 862719011734 H-loop/switch region; other site 862719011735 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719011736 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719011737 Walker A/P-loop; other site 862719011738 ATP binding site [chemical binding]; other site 862719011739 Q-loop/lid; other site 862719011740 ABC transporter signature motif; other site 862719011741 Walker B; other site 862719011742 D-loop; other site 862719011743 H-loop/switch region; other site 862719011744 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719011745 TM-ABC transporter signature motif; other site 862719011746 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719011747 TM-ABC transporter signature motif; other site 862719011748 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719011749 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 862719011750 putative ligand binding site [chemical binding]; other site 862719011751 PaaX-like protein; Region: PaaX; pfam07848 862719011752 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 862719011753 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 862719011754 Sensors of blue-light using FAD; Region: BLUF; cl04855 862719011755 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719011756 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 862719011757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719011758 catalytic loop [active] 862719011759 iron binding site [ion binding]; other site 862719011760 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 862719011761 FAD binding pocket [chemical binding]; other site 862719011762 FAD binding motif [chemical binding]; other site 862719011763 phosphate binding motif [ion binding]; other site 862719011764 beta-alpha-beta structure motif; other site 862719011765 NAD binding pocket [chemical binding]; other site 862719011766 Cache domain; Region: Cache_1; pfam02743 862719011767 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719011768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011770 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719011771 dimer interface [polypeptide binding]; other site 862719011772 putative CheW interface [polypeptide binding]; other site 862719011773 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719011774 Cupin domain; Region: Cupin_2; cl09118 862719011775 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719011776 Helix-turn-helix domains; Region: HTH; cl00088 862719011777 Transposase domain (DUF772); Region: DUF772; cl15789 862719011778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719011779 Transposase domain (DUF772); Region: DUF772; cl15789 862719011780 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 862719011781 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 862719011782 putative trimer interface [polypeptide binding]; other site 862719011783 putative metal binding site [ion binding]; other site 862719011784 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 862719011785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011786 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 862719011787 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 862719011788 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 862719011789 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862719011790 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862719011791 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 862719011792 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 862719011793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 862719011794 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 862719011795 active site 862719011796 dimer interface [polypeptide binding]; other site 862719011797 motif 1; other site 862719011798 motif 2; other site 862719011799 motif 3; other site 862719011800 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 862719011801 anticodon binding site; other site 862719011802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719011803 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 862719011804 quinone interaction residues [chemical binding]; other site 862719011805 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 862719011806 active site 862719011807 catalytic residues [active] 862719011808 FMN binding site [chemical binding]; other site 862719011809 substrate binding site [chemical binding]; other site 862719011810 Protein of unknown function (DUF952); Region: DUF952; cl01393 862719011811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 862719011812 Terminase-like family; Region: Terminase_6; pfam03237 862719011813 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 862719011814 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 862719011815 hypothetical protein; Region: PHA00661 862719011816 hypothetical protein; Region: PHA00661 862719011817 hypothetical protein; Region: PHA00662 862719011818 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 862719011819 Phage Tail Collar Domain; Region: Collar; pfam07484 862719011820 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719011821 metal binding site 2 [ion binding]; metal-binding site 862719011822 putative DNA binding helix; other site 862719011823 metal binding site 1 [ion binding]; metal-binding site 862719011824 dimer interface [polypeptide binding]; other site 862719011825 structural Zn2+ binding site [ion binding]; other site 862719011826 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 862719011827 E-class dimer interface [polypeptide binding]; other site 862719011828 P-class dimer interface [polypeptide binding]; other site 862719011829 active site 862719011830 Cu2+ binding site [ion binding]; other site 862719011831 Zn2+ binding site [ion binding]; other site 862719011832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719011833 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719011834 ATP binding site [chemical binding]; other site 862719011835 Mg++ binding site [ion binding]; other site 862719011836 motif III; other site 862719011837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719011838 nucleotide binding region [chemical binding]; other site 862719011839 ATP-binding site [chemical binding]; other site 862719011840 glutathionine S-transferase; Provisional; Region: PRK10542 862719011841 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 862719011842 C-terminal domain interface [polypeptide binding]; other site 862719011843 GSH binding site (G-site) [chemical binding]; other site 862719011844 dimer interface [polypeptide binding]; other site 862719011845 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 862719011846 N-terminal domain interface [polypeptide binding]; other site 862719011847 dimer interface [polypeptide binding]; other site 862719011848 substrate binding pocket (H-site) [chemical binding]; other site 862719011849 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719011850 dinuclear metal binding motif [ion binding]; other site 862719011851 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 862719011852 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 862719011853 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 862719011854 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 862719011855 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862719011856 alpha subunit interaction interface [polypeptide binding]; other site 862719011857 Walker A motif; other site 862719011858 ATP binding site [chemical binding]; other site 862719011859 Walker B motif; other site 862719011860 inhibitor binding site; inhibition site 862719011861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719011862 ATP synthase; Region: ATP-synt; cl00365 862719011863 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 862719011864 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 862719011865 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 862719011866 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 862719011867 beta subunit interaction interface [polypeptide binding]; other site 862719011868 Walker A motif; other site 862719011869 ATP binding site [chemical binding]; other site 862719011870 Walker B motif; other site 862719011871 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719011872 Plant ATP synthase F0; Region: YMF19; cl07975 862719011873 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 862719011874 Cache domain; Region: Cache_2; cl07034 862719011875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 862719011876 primosome assembly protein PriA; Validated; Region: PRK05580 862719011877 Helix-turn-helix domains; Region: HTH; cl00088 862719011878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719011879 ATP binding site [chemical binding]; other site 862719011880 putative Mg++ binding site [ion binding]; other site 862719011881 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 862719011882 active site 862719011883 intersubunit interactions; other site 862719011884 catalytic residue [active] 862719011885 GAF domain; Region: GAF; cl15785 862719011886 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 862719011887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719011888 active site 862719011889 DNA binding site [nucleotide binding] 862719011890 Int/Topo IB signature motif; other site 862719011891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719011892 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011893 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011894 dimer interface [polypeptide binding]; other site 862719011895 putative CheW interface [polypeptide binding]; other site 862719011896 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 862719011897 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 862719011898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719011899 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719011900 Entericidin EcnA/B family; Region: Entericidin; cl02322 862719011901 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719011902 DNA-binding site [nucleotide binding]; DNA binding site 862719011903 RNA-binding motif; other site 862719011904 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 862719011905 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 862719011906 putative ribose interaction site [chemical binding]; other site 862719011907 putative ADP binding site [chemical binding]; other site 862719011908 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719011909 active site 862719011910 nucleotide binding site [chemical binding]; other site 862719011911 HIGH motif; other site 862719011912 KMSKS motif; other site 862719011913 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719011914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011915 ATP binding site [chemical binding]; other site 862719011916 Mg2+ binding site [ion binding]; other site 862719011917 G-X-G motif; other site 862719011918 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 862719011919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719011920 S-adenosylmethionine binding site [chemical binding]; other site 862719011921 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719011922 ParA-like protein; Provisional; Region: PHA02518 862719011923 P-loop; other site 862719011924 Magnesium ion binding site [ion binding]; other site 862719011925 Uncharacterized conserved protein [Function unknown]; Region: COG3025 862719011926 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 862719011927 putative active site [active] 862719011928 putative metal binding residues [ion binding]; other site 862719011929 signature motif; other site 862719011930 putative triphosphate binding site [ion binding]; other site 862719011931 CHAD domain; Region: CHAD; cl10506 862719011932 Phosphoglycerate kinase; Region: PGK; pfam00162 862719011933 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 862719011934 substrate binding site [chemical binding]; other site 862719011935 hinge regions; other site 862719011936 ADP binding site [chemical binding]; other site 862719011937 catalytic site [active] 862719011938 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 862719011939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011940 Walker A motif; other site 862719011941 ATP binding site [chemical binding]; other site 862719011942 Walker B motif; other site 862719011943 arginine finger; other site 862719011944 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 862719011945 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 862719011946 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 862719011947 recombination protein RecR; Reviewed; Region: recR; PRK00076 862719011948 RecR protein; Region: RecR; pfam02132 862719011949 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 862719011950 putative active site [active] 862719011951 putative metal-binding site [ion binding]; other site 862719011952 tetramer interface [polypeptide binding]; other site 862719011953 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 862719011954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719011956 active site 862719011957 HIGH motif; other site 862719011958 nucleotide binding site [chemical binding]; other site 862719011959 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719011960 active site 862719011961 KMSKS motif; other site 862719011962 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 862719011963 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 862719011964 active site 862719011965 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719011966 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 862719011967 DNA Polymerase Y-family; Region: PolY_like; cd03468 862719011968 active site 862719011969 DNA binding site [nucleotide binding] 862719011970 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719011971 NMT1-like family; Region: NMT1_2; cl15260 862719011972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719011973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719011974 Coenzyme A binding pocket [chemical binding]; other site 862719011975 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719011976 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 862719011977 C-terminal domain interface [polypeptide binding]; other site 862719011978 GSH binding site (G-site) [chemical binding]; other site 862719011979 dimer interface [polypeptide binding]; other site 862719011980 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 862719011981 dimer interface [polypeptide binding]; other site 862719011982 N-terminal domain interface [polypeptide binding]; other site 862719011983 substrate binding pocket (H-site) [chemical binding]; other site 862719011984 heat shock protein 90; Provisional; Region: PRK05218 862719011985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011986 ATP binding site [chemical binding]; other site 862719011987 Mg2+ binding site [ion binding]; other site 862719011988 G-X-G motif; other site 862719011989 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719011990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011991 dimer interface [polypeptide binding]; other site 862719011992 phosphorylation site [posttranslational modification] 862719011993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011994 ATP binding site [chemical binding]; other site 862719011995 Mg2+ binding site [ion binding]; other site 862719011996 G-X-G motif; other site 862719011997 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719011998 metal binding site 2 [ion binding]; metal-binding site 862719011999 putative DNA binding helix; other site 862719012000 metal binding site 1 [ion binding]; metal-binding site 862719012001 dimer interface [polypeptide binding]; other site 862719012002 structural Zn2+ binding site [ion binding]; other site 862719012003 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719012004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719012005 active site 862719012006 phosphorylation site [posttranslational modification] 862719012007 intermolecular recognition site; other site 862719012008 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 862719012009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719012010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719012011 DNA binding residues [nucleotide binding] 862719012012 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719012013 DsrE/DsrF-like family; Region: DrsE; cl00672 862719012014 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 862719012015 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 862719012016 ATP binding site [chemical binding]; other site 862719012017 substrate interface [chemical binding]; other site 862719012018 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719012019 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 862719012020 dimer interface [polypeptide binding]; other site 862719012021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012022 catalytic residue [active] 862719012023 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719012024 Helix-turn-helix domains; Region: HTH; cl00088 862719012025 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 862719012026 Helix-turn-helix domains; Region: HTH; cl00088 862719012027 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 862719012028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719012029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719012030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012031 dimer interface [polypeptide binding]; other site 862719012032 conserved gate region; other site 862719012033 putative PBP binding loops; other site 862719012034 ABC-ATPase subunit interface; other site 862719012035 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719012036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012037 dimer interface [polypeptide binding]; other site 862719012038 conserved gate region; other site 862719012039 ABC-ATPase subunit interface; other site 862719012040 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 862719012041 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719012042 Walker A/P-loop; other site 862719012043 ATP binding site [chemical binding]; other site 862719012044 Q-loop/lid; other site 862719012045 ABC transporter signature motif; other site 862719012046 Walker B; other site 862719012047 D-loop; other site 862719012048 H-loop/switch region; other site 862719012049 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719012050 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 862719012051 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719012052 Walker A/P-loop; other site 862719012053 ATP binding site [chemical binding]; other site 862719012054 Q-loop/lid; other site 862719012055 ABC transporter signature motif; other site 862719012056 Walker B; other site 862719012057 D-loop; other site 862719012058 H-loop/switch region; other site 862719012059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719012060 non-specific DNA binding site [nucleotide binding]; other site 862719012061 salt bridge; other site 862719012062 sequence-specific DNA binding site [nucleotide binding]; other site 862719012063 Protein of unknown function (DUF497); Region: DUF497; cl01108 862719012064 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719012065 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719012066 HerA helicase [Replication, recombination, and repair]; Region: COG0433 862719012067 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719012068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719012069 Helix-turn-helix domains; Region: HTH; cl00088 862719012070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719012071 dimerization interface [polypeptide binding]; other site 862719012072 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 862719012073 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 862719012074 putative NAD(P) binding site [chemical binding]; other site 862719012075 dimer interface [polypeptide binding]; other site 862719012076 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719012077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012078 active site 862719012079 phosphorylation site [posttranslational modification] 862719012080 intermolecular recognition site; other site 862719012081 dimerization interface [polypeptide binding]; other site 862719012082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719012083 dimerization interface [polypeptide binding]; other site 862719012084 DNA binding residues [nucleotide binding] 862719012085 EamA-like transporter family; Region: EamA; cl01037 862719012086 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719012087 EamA-like transporter family; Region: EamA; cl01037 862719012088 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719012089 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719012090 ring oligomerisation interface [polypeptide binding]; other site 862719012091 ATP/Mg binding site [chemical binding]; other site 862719012092 stacking interactions; other site 862719012093 hinge regions; other site 862719012094 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 862719012095 oligomerisation interface [polypeptide binding]; other site 862719012096 mobile loop; other site 862719012097 roof hairpin; other site 862719012098 Usg-like family; Region: Usg; cl11567 862719012099 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 862719012100 catalytic residues [active] 862719012101 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 862719012102 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 862719012103 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719012104 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719012105 ligand binding site [chemical binding]; other site 862719012106 flexible hinge region; other site 862719012107 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719012108 putative switch regulator; other site 862719012109 non-specific DNA interactions [nucleotide binding]; other site 862719012110 DNA binding site [nucleotide binding] 862719012111 sequence specific DNA binding site [nucleotide binding]; other site 862719012112 putative cAMP binding site [chemical binding]; other site 862719012113 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 862719012114 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 862719012115 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862719012116 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719012117 metal-binding site [ion binding] 862719012118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719012119 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719012120 FixH; Region: FixH; cl01254 862719012121 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 862719012122 Cytochrome c; Region: Cytochrom_C; cl11414 862719012123 Cytochrome c; Region: Cytochrom_C; cl11414 862719012124 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 862719012125 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 862719012126 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 862719012127 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 862719012128 Low-spin heme binding site [chemical binding]; other site 862719012129 Putative water exit pathway; other site 862719012130 Binuclear center (active site) [active] 862719012131 Putative proton exit pathway; other site 862719012132 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 862719012133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012134 S-adenosylmethionine binding site [chemical binding]; other site 862719012135 TRAM domain; Region: TRAM; cl01282 862719012136 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 862719012137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719012138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719012139 active site 862719012140 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719012141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012142 dimer interface [polypeptide binding]; other site 862719012143 conserved gate region; other site 862719012144 putative PBP binding loops; other site 862719012145 ABC-ATPase subunit interface; other site 862719012146 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719012147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012148 dimer interface [polypeptide binding]; other site 862719012149 ABC-ATPase subunit interface; other site 862719012150 putative PBP binding loops; other site 862719012151 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719012152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012153 active site 862719012154 phosphorylation site [posttranslational modification] 862719012155 intermolecular recognition site; other site 862719012156 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 862719012157 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 862719012158 substrate-cofactor binding pocket; other site 862719012159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012160 catalytic residue [active] 862719012161 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 862719012162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719012163 active site 862719012164 diguanylate cyclase; Provisional; Region: PRK09894 862719012165 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 862719012166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012167 metal binding site [ion binding]; metal-binding site 862719012168 active site 862719012169 I-site; other site 862719012170 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 862719012171 active site 862719012172 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 862719012173 active site 862719012174 dimer interface [polypeptide binding]; other site 862719012175 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 862719012176 heme binding pocket [chemical binding]; other site 862719012177 heme ligand [chemical binding]; other site 862719012178 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719012179 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 862719012180 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 862719012181 Walker A/P-loop; other site 862719012182 ATP binding site [chemical binding]; other site 862719012183 Q-loop/lid; other site 862719012184 ABC transporter signature motif; other site 862719012185 Walker B; other site 862719012186 D-loop; other site 862719012187 H-loop/switch region; other site 862719012188 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719012189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012190 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719012191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012192 dimer interface [polypeptide binding]; other site 862719012193 putative CheW interface [polypeptide binding]; other site 862719012194 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 862719012195 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 862719012196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719012197 G1 box; other site 862719012198 GTP/Mg2+ binding site [chemical binding]; other site 862719012199 G2 box; other site 862719012200 Switch I region; other site 862719012201 G3 box; other site 862719012202 Switch II region; other site 862719012203 G4 box; other site 862719012204 G5 box; other site 862719012205 TIR domain; Region: TIR_2; cl15770 862719012206 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 862719012207 DTW domain; Region: DTW; cl01221 862719012208 Cell division inhibitor SulA; Region: SulA; cl01880 862719012209 Bacterial SH3 domain; Region: SH3_3; cl02551 862719012210 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 862719012211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719012212 FeS/SAM binding site; other site 862719012213 HemN C-terminal domain; Region: HemN_C; pfam06969 862719012214 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 862719012215 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 862719012216 Integral membrane protein TerC family; Region: TerC; cl10468 862719012217 FOG: CBS domain [General function prediction only]; Region: COG0517 862719012218 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719012219 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 862719012220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719012221 Helix-turn-helix domains; Region: HTH; cl00088 862719012222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719012223 dimerization interface [polypeptide binding]; other site 862719012224 Ferredoxin [Energy production and conversion]; Region: COG1146 862719012225 4Fe-4S binding domain; Region: Fer4; cl02805 862719012226 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 862719012227 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 862719012228 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719012229 active site 862719012230 metal binding site [ion binding]; metal-binding site 862719012231 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 862719012232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719012233 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719012234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719012235 DNA binding residues [nucleotide binding] 862719012236 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 862719012237 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 862719012238 purine monophosphate binding site [chemical binding]; other site 862719012239 dimer interface [polypeptide binding]; other site 862719012240 putative catalytic residues [active] 862719012241 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 862719012242 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 862719012243 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 862719012244 16S rRNA methyltransferase B; Provisional; Region: PRK10901 862719012245 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 862719012246 putative RNA binding site [nucleotide binding]; other site 862719012247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012248 S-adenosylmethionine binding site [chemical binding]; other site 862719012249 enoyl-CoA hydratase; Provisional; Region: PRK06127 862719012250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719012251 substrate binding site [chemical binding]; other site 862719012252 oxyanion hole (OAH) forming residues; other site 862719012253 trimer interface [polypeptide binding]; other site 862719012254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719012255 putative transporter; Provisional; Region: PRK10504 862719012256 putative substrate translocation pore; other site 862719012257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719012258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719012259 Helix-turn-helix domains; Region: HTH; cl00088 862719012260 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719012261 putative effector binding pocket; other site 862719012262 dimerization interface [polypeptide binding]; other site 862719012263 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719012264 Haemolysin-III related; Region: HlyIII; cl03831 862719012265 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 862719012266 Helix-turn-helix domains; Region: HTH; cl00088 862719012267 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719012268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012269 Bacterial SH3 domain; Region: SH3_3; cl02551 862719012270 Bacterial SH3 domain; Region: SH3_3; cl02551 862719012271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719012272 putative substrate translocation pore; other site 862719012273 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 862719012274 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 862719012275 ANP binding site [chemical binding]; other site 862719012276 Substrate Binding Site II [chemical binding]; other site 862719012277 Substrate Binding Site I [chemical binding]; other site 862719012278 RES domain; Region: RES; cl02411 862719012279 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 862719012280 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 862719012281 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 862719012282 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 862719012283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719012284 active site 862719012285 catalytic tetrad [active] 862719012286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719012287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012288 NAD(P) binding site [chemical binding]; other site 862719012289 active site 862719012290 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 862719012291 EamA-like transporter family; Region: EamA; cl01037 862719012292 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719012293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719012294 Histidine kinase; Region: HisKA_2; cl06527 862719012295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012296 ATP binding site [chemical binding]; other site 862719012297 Mg2+ binding site [ion binding]; other site 862719012298 G-X-G motif; other site 862719012299 ornithine cyclodeaminase; Validated; Region: PRK06141 862719012300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012301 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719012302 IHF dimer interface [polypeptide binding]; other site 862719012303 IHF - DNA interface [nucleotide binding]; other site 862719012304 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012305 secreted effector protein PipB2; Provisional; Region: PRK15196 862719012306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012307 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719012308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719012312 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719012313 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719012314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719012315 protein binding site [polypeptide binding]; other site 862719012316 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 862719012317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719012318 Histidine kinase; Region: HisKA_2; cl06527 862719012319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012320 ATP binding site [chemical binding]; other site 862719012321 Mg2+ binding site [ion binding]; other site 862719012322 G-X-G motif; other site 862719012323 Ferritin-like domain; Region: Ferritin; pfam00210 862719012324 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 862719012325 dimerization interface [polypeptide binding]; other site 862719012326 DPS ferroxidase diiron center [ion binding]; other site 862719012327 ion pore; other site 862719012328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012330 dimer interface [polypeptide binding]; other site 862719012331 putative CheW interface [polypeptide binding]; other site 862719012332 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16303747, 17628132, 8522505; Product type prc : putative receptor 862719012333 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 862719012334 elongation factor G; Reviewed; Region: PRK12740 862719012335 G1 box; other site 862719012336 putative GEF interaction site [polypeptide binding]; other site 862719012337 GTP/Mg2+ binding site [chemical binding]; other site 862719012338 Switch I region; other site 862719012339 G2 box; other site 862719012340 G3 box; other site 862719012341 Switch II region; other site 862719012342 G4 box; other site 862719012343 G5 box; other site 862719012344 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719012345 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862719012346 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719012347 PemK-like protein; Region: PemK; cl00995 862719012348 Helix-turn-helix domains; Region: HTH; cl00088 862719012349 Helix-turn-helix domains; Region: HTH; cl00088 862719012350 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719012351 aspartate aminotransferase; Provisional; Region: PRK05764 862719012352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719012353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012354 homodimer interface [polypeptide binding]; other site 862719012355 catalytic residue [active] 862719012356 Cytochrome C'; Region: Cytochrom_C_2; cl01610 862719012357 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 862719012358 Cytochrome c; Region: Cytochrom_C; cl11414 862719012359 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719012360 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 862719012361 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 862719012362 putative active site [active] 862719012363 putative metal binding site [ion binding]; other site 862719012364 PAS domain S-box; Region: sensory_box; TIGR00229 862719012365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012366 putative active site [active] 862719012367 heme pocket [chemical binding]; other site 862719012368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012369 metal binding site [ion binding]; metal-binding site 862719012370 active site 862719012371 I-site; other site 862719012372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719012373 Bacteriophage head to tail connecting protein; Region: Head-tail_con; cl10251 862719012374 Predicted transcriptional regulator [Transcription]; Region: COG2932 862719012375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719012376 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719012377 Catalytic site [active] 862719012378 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 862719012379 homodimer interface [polypeptide binding]; other site 862719012380 substrate-cofactor binding pocket; other site 862719012381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012382 catalytic residue [active] 862719012383 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 862719012384 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719012385 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 862719012386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012387 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862719012388 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 862719012389 putative SdhC subunit interface [polypeptide binding]; other site 862719012390 putative proximal heme binding site [chemical binding]; other site 862719012391 putative Iron-sulfur protein interface [polypeptide binding]; other site 862719012392 putative proximal quinone binding site; other site 862719012393 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 862719012394 Iron-sulfur protein interface; other site 862719012395 proximal quinone binding site [chemical binding]; other site 862719012396 SdhD (CybS) interface [polypeptide binding]; other site 862719012397 proximal heme binding site [chemical binding]; other site 862719012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012399 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 862719012400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719012401 FeS/SAM binding site; other site 862719012402 Response regulator receiver domain; Region: Response_reg; pfam00072 862719012403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012404 active site 862719012405 phosphorylation site [posttranslational modification] 862719012406 intermolecular recognition site; other site 862719012407 dimerization interface [polypeptide binding]; other site 862719012408 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719012409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719012410 Zn2+ binding site [ion binding]; other site 862719012411 Mg2+ binding site [ion binding]; other site 862719012412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 862719012413 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 862719012414 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 862719012415 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 862719012416 C-terminal domain interface [polypeptide binding]; other site 862719012417 GSH binding site (G-site) [chemical binding]; other site 862719012418 dimer interface [polypeptide binding]; other site 862719012419 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862719012420 N-terminal domain interface [polypeptide binding]; other site 862719012421 dimer interface [polypeptide binding]; other site 862719012422 substrate binding pocket (H-site) [chemical binding]; other site 862719012423 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 862719012424 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 862719012425 metal binding site [ion binding]; metal-binding site 862719012426 putative dimer interface [polypeptide binding]; other site 862719012427 PrcB C-terminal; Region: PrcB_C; pfam14343 862719012428 PAS fold; Region: PAS_4; pfam08448 862719012429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012430 putative active site [active] 862719012431 heme pocket [chemical binding]; other site 862719012432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012433 metal binding site [ion binding]; metal-binding site 862719012434 active site 862719012435 I-site; other site 862719012436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719012437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719012438 Ligand Binding Site [chemical binding]; other site 862719012439 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719012440 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 862719012441 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 862719012442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012443 S-adenosylmethionine binding site [chemical binding]; other site 862719012444 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 862719012445 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 862719012446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719012447 active site 862719012448 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 862719012449 GSH binding site [chemical binding]; other site 862719012450 catalytic residues [active] 862719012451 Predicted amidohydrolase [General function prediction only]; Region: COG0388 862719012452 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 862719012453 putative active site [active] 862719012454 catalytic triad [active] 862719012455 dimer interface [polypeptide binding]; other site 862719012456 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862719012457 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 862719012458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719012459 ligand binding site [chemical binding]; other site 862719012460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 862719012461 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719012462 metal binding triad; other site 862719012463 Sodium:solute symporter family; Region: SSF; cl00456 862719012464 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 862719012465 Protein of unknown function, DUF485; Region: DUF485; cl01231 862719012466 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 862719012467 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 862719012468 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719012469 L-asparaginase II; Region: Asparaginase_II; cl01842 862719012470 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719012471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719012472 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 862719012473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012474 aminotransferase; Provisional; Region: PRK06105 862719012475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719012476 inhibitor-cofactor binding pocket; inhibition site 862719012477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012478 catalytic residue [active] 862719012479 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 862719012480 Clp amino terminal domain; Region: Clp_N; pfam02861 862719012481 Clp amino terminal domain; Region: Clp_N; pfam02861 862719012482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012483 Walker A motif; other site 862719012484 ATP binding site [chemical binding]; other site 862719012485 Walker B motif; other site 862719012486 arginine finger; other site 862719012487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012488 Walker A motif; other site 862719012489 ATP binding site [chemical binding]; other site 862719012490 Walker B motif; other site 862719012491 arginine finger; other site 862719012492 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719012493 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 862719012494 nudix motif; other site 862719012495 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 862719012496 MOSC domain; Region: MOSC; pfam03473 862719012497 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 862719012498 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 862719012499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012500 S-adenosylmethionine binding site [chemical binding]; other site 862719012501 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719012502 putative active site [active] 862719012503 peptide chain release factor 1; Validated; Region: prfA; PRK00591 862719012504 RF-1 domain; Region: RF-1; cl02875 862719012505 RF-1 domain; Region: RF-1; cl02875 862719012506 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 862719012507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012508 NAD(P) binding pocket [chemical binding]; other site 862719012509 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 862719012510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 862719012511 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 862719012512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719012513 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 862719012514 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 862719012515 GAF domain; Region: GAF; cl15785 862719012516 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719012517 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719012518 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719012519 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 862719012520 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719012521 FMN binding site [chemical binding]; other site 862719012522 substrate binding site [chemical binding]; other site 862719012523 putative catalytic residue [active] 862719012524 aspartate kinase; Reviewed; Region: PRK06635 862719012525 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 862719012526 putative nucleotide binding site [chemical binding]; other site 862719012527 putative catalytic residues [active] 862719012528 putative Mg ion binding site [ion binding]; other site 862719012529 putative aspartate binding site [chemical binding]; other site 862719012530 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 862719012531 putative allosteric regulatory site; other site 862719012532 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 862719012533 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 862719012534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012535 S-adenosylmethionine binding site [chemical binding]; other site 862719012536 YokU-like protein; Region: YokU; cl15819 862719012537 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 862719012538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719012539 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719012540 putative active site [active] 862719012541 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719012542 active site 862719012543 phosphorylation site [posttranslational modification] 862719012544 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 862719012545 30S subunit binding site; other site 862719012546 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 862719012547 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 862719012548 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 862719012549 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 862719012550 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 862719012551 Walker A/P-loop; other site 862719012552 ATP binding site [chemical binding]; other site 862719012553 Q-loop/lid; other site 862719012554 ABC transporter signature motif; other site 862719012555 Walker B; other site 862719012556 D-loop; other site 862719012557 H-loop/switch region; other site 862719012558 OstA-like protein; Region: OstA; cl00844 862719012559 OstA-like protein; Region: OstA; cl00844 862719012560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 862719012561 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 862719012562 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 862719012563 putative active site [active] 862719012564 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 862719012565 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 862719012566 catalytic site [active] 862719012567 putative active site [active] 862719012568 putative substrate binding site [chemical binding]; other site 862719012569 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 862719012570 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 862719012571 putative NAD(P) binding site [chemical binding]; other site 862719012572 active site 862719012573 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719012574 Bacitracin resistance protein BacA; Region: BacA; cl00858 862719012575 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 862719012576 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 862719012577 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 862719012578 active site 862719012579 dimer interface [polypeptide binding]; other site 862719012580 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 862719012581 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 862719012582 active site 862719012583 FMN binding site [chemical binding]; other site 862719012584 substrate binding site [chemical binding]; other site 862719012585 3Fe-4S cluster binding site [ion binding]; other site 862719012586 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 862719012587 domain interface; other site 862719012588 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 862719012589 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 862719012590 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719012591 putative C-terminal domain interface [polypeptide binding]; other site 862719012592 putative GSH binding site (G-site) [chemical binding]; other site 862719012593 putative dimer interface [polypeptide binding]; other site 862719012594 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 862719012595 putative substrate binding pocket (H-site) [chemical binding]; other site 862719012596 putative N-terminal domain interface [polypeptide binding]; other site 862719012597 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 862719012598 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862719012599 interface (dimer of trimers) [polypeptide binding]; other site 862719012600 Substrate-binding/catalytic site; other site 862719012601 Zn-binding sites [ion binding]; other site 862719012602 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719012603 FliG C-terminal domain; Region: FliG_C; pfam01706 862719012604 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719012605 ligand binding site [chemical binding]; other site 862719012606 flexible hinge region; other site 862719012607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719012608 dimer interface [polypeptide binding]; other site 862719012609 phosphorylation site [posttranslational modification] 862719012610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012611 ATP binding site [chemical binding]; other site 862719012612 G-X-G motif; other site 862719012613 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862719012614 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 862719012615 active site 862719012616 NAD-dependent deacetylase; Provisional; Region: PRK00481 862719012617 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 862719012618 NAD+ binding site [chemical binding]; other site 862719012619 substrate binding site [chemical binding]; other site 862719012620 Zn binding site [ion binding]; other site 862719012621 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 862719012622 putative uracil binding site [chemical binding]; other site 862719012623 putative active site [active] 862719012624 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 862719012625 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 862719012626 aromatic arch; other site 862719012627 DCoH dimer interaction site [polypeptide binding]; other site 862719012628 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 862719012629 DCoH tetramer interaction site [polypeptide binding]; other site 862719012630 substrate binding site [chemical binding]; other site 862719012631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012633 dimer interface [polypeptide binding]; other site 862719012634 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719012635 putative CheW interface [polypeptide binding]; other site 862719012636 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719012637 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719012638 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 862719012639 dimer interface [polypeptide binding]; other site 862719012640 substrate binding site [chemical binding]; other site 862719012641 metal binding sites [ion binding]; metal-binding site 862719012642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012643 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719012644 NAD(P) binding site [chemical binding]; other site 862719012645 active site 862719012646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719012647 Helix-turn-helix domains; Region: HTH; cl00088 862719012648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719012649 dimerization interface [polypeptide binding]; other site 862719012650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012651 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 862719012652 NAD(P) binding site [chemical binding]; other site 862719012653 LDH/MDH dimer interface [polypeptide binding]; other site 862719012654 substrate binding site [chemical binding]; other site 862719012655 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 862719012656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012657 CoA-ligase; Region: Ligase_CoA; cl02894 862719012658 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719012659 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719012660 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719012661 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719012662 Helix-turn-helix domains; Region: HTH; cl00088 862719012663 Helix-turn-helix domains; Region: HTH; cl00088 862719012664 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 862719012665 alanine-tRNA ligase; Region: PLN02961 862719012666 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 862719012667 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 862719012668 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 862719012669 dimerization interface [polypeptide binding]; other site 862719012670 active site 862719012671 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 862719012672 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 862719012673 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 862719012674 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 862719012675 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 862719012676 homodimer interface [polypeptide binding]; other site 862719012677 NADP binding site [chemical binding]; other site 862719012678 substrate binding site [chemical binding]; other site 862719012679 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 862719012680 YGGT family; Region: YGGT; cl00508 862719012681 EamA-like transporter family; Region: EamA; cl01037 862719012682 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 862719012683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719012684 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 862719012685 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719012686 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 862719012687 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 862719012688 substrate binding site [chemical binding]; other site 862719012689 active site 862719012690 catalytic residues [active] 862719012691 heterodimer interface [polypeptide binding]; other site 862719012692 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 862719012693 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 862719012694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012695 catalytic residue [active] 862719012696 Response regulator receiver domain; Region: Response_reg; pfam00072 862719012697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012698 active site 862719012699 phosphorylation site [posttranslational modification] 862719012700 intermolecular recognition site; other site 862719012701 dimerization interface [polypeptide binding]; other site 862719012702 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719012703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862719012704 DNA-binding site [nucleotide binding]; DNA binding site 862719012705 RNA-binding motif; other site 862719012706 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719012707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012708 active site 862719012709 phosphorylation site [posttranslational modification] 862719012710 intermolecular recognition site; other site 862719012711 dimerization interface [polypeptide binding]; other site 862719012712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012713 Walker A motif; other site 862719012714 ATP binding site [chemical binding]; other site 862719012715 Walker B motif; other site 862719012716 arginine finger; other site 862719012717 Helix-turn-helix domains; Region: HTH; cl00088 862719012718 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 862719012719 Flavoprotein; Region: Flavoprotein; cl08021 862719012720 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 862719012721 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 862719012722 trimer interface [polypeptide binding]; other site 862719012723 active site 862719012724 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719012725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719012727 dimer interface [polypeptide binding]; other site 862719012728 phosphorylation site [posttranslational modification] 862719012729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012730 ATP binding site [chemical binding]; other site 862719012731 Mg2+ binding site [ion binding]; other site 862719012732 G-X-G motif; other site 862719012733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012734 Response regulator receiver domain; Region: Response_reg; pfam00072 862719012735 active site 862719012736 phosphorylation site [posttranslational modification] 862719012737 intermolecular recognition site; other site 862719012738 dimerization interface [polypeptide binding]; other site 862719012739 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719012740 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719012741 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 862719012742 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 862719012743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719012744 active site 862719012745 DNA binding site [nucleotide binding] 862719012746 Int/Topo IB signature motif; other site 862719012747 shikimate kinase; Provisional; Region: PRK13946 862719012748 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 862719012749 ADP binding site [chemical binding]; other site 862719012750 magnesium binding site [ion binding]; other site 862719012751 putative shikimate binding site; other site 862719012752 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 862719012753 active site 862719012754 dimer interface [polypeptide binding]; other site 862719012755 metal binding site [ion binding]; metal-binding site 862719012756 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 862719012757 putative hydrophobic ligand binding site [chemical binding]; other site 862719012758 protein interface [polypeptide binding]; other site 862719012759 gate; other site 862719012760 FOG: CBS domain [General function prediction only]; Region: COG0517 862719012761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 862719012762 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 862719012763 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719012764 BolA-like protein; Region: BolA; cl00386 862719012765 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719012766 HSP70 interaction site [polypeptide binding]; other site 862719012767 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 862719012768 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 862719012769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719012770 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 862719012771 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 862719012772 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 862719012773 metal ion-dependent adhesion site (MIDAS); other site 862719012774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012775 cyclase homology domain; Region: CHD; cd07302 862719012776 nucleotidyl binding site; other site 862719012777 metal binding site [ion binding]; metal-binding site 862719012778 dimer interface [polypeptide binding]; other site 862719012779 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 862719012780 Peptidase family M48; Region: Peptidase_M48; cl12018 862719012781 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 862719012782 Catalytic site; other site 862719012783 Cytochrome c; Region: Cytochrom_C; cl11414 862719012784 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719012785 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719012786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719012787 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719012788 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719012789 dimerization domain swap beta strand [polypeptide binding]; other site 862719012790 regulatory protein interface [polypeptide binding]; other site 862719012791 active site 862719012792 regulatory phosphorylation site [posttranslational modification]; other site 862719012793 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 862719012794 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 862719012795 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 862719012796 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 862719012797 Hpr binding site; other site 862719012798 active site 862719012799 homohexamer subunit interaction site [polypeptide binding]; other site 862719012800 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 862719012801 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 862719012802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719012803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719012804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719012805 dimer interface [polypeptide binding]; other site 862719012806 phosphorylation site [posttranslational modification] 862719012807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012808 ATP binding site [chemical binding]; other site 862719012809 Mg2+ binding site [ion binding]; other site 862719012810 G-X-G motif; other site 862719012811 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 862719012812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012813 active site 862719012814 phosphorylation site [posttranslational modification] 862719012815 intermolecular recognition site; other site 862719012816 dimerization interface [polypeptide binding]; other site 862719012817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719012818 DNA binding site [nucleotide binding] 862719012819 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719012820 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 862719012821 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 862719012822 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 862719012823 active site 862719012824 substrate-binding site [chemical binding]; other site 862719012825 metal-binding site [ion binding] 862719012826 GTP binding site [chemical binding]; other site 862719012827 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 862719012828 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 862719012829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719012830 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862719012831 putative acyl-acceptor binding pocket; other site 862719012832 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719012833 Predicted transcriptional regulator [Transcription]; Region: COG4957 862719012834 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719012835 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 862719012836 CPxP motif; other site 862719012837 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719012838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719012839 Coenzyme A binding pocket [chemical binding]; other site 862719012840 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 862719012841 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 862719012842 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 862719012843 putative active site [active] 862719012844 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 862719012845 chaperone protein DnaJ; Provisional; Region: PRK10767 862719012846 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719012847 HSP70 interaction site [polypeptide binding]; other site 862719012848 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 862719012849 substrate binding site [polypeptide binding]; other site 862719012850 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 862719012851 Zn binding sites [ion binding]; other site 862719012852 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862719012853 dimer interface [polypeptide binding]; other site 862719012854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012855 metal binding site [ion binding]; metal-binding site 862719012856 active site 862719012857 I-site; other site 862719012858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719012859 conjugal transfer protein TrbA; Provisional; Region: PRK13890 862719012860 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 862719012861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719012862 putative NAD(P) binding site [chemical binding]; other site 862719012863 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 862719012864 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 862719012865 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 862719012866 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 862719012867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719012868 active site 862719012869 catalytic tetrad [active] 862719012870 FIST N domain; Region: FIST; cl10701 862719012871 FIST C domain; Region: FIST_C; pfam10442 862719012872 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 862719012873 active site 862719012874 catalytic triad [active] 862719012875 oxyanion hole [active] 862719012876 switch loop; other site 862719012877 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 862719012878 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 862719012879 Walker A/P-loop; other site 862719012880 ATP binding site [chemical binding]; other site 862719012881 Q-loop/lid; other site 862719012882 ABC transporter signature motif; other site 862719012883 Walker B; other site 862719012884 D-loop; other site 862719012885 H-loop/switch region; other site 862719012886 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 862719012887 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719012888 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 862719012889 Uncharacterized conserved protein [Function unknown]; Region: COG1912 862719012890 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 862719012891 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 862719012892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012893 active site 862719012894 phosphorylation site [posttranslational modification] 862719012895 intermolecular recognition site; other site 862719012896 dimerization interface [polypeptide binding]; other site 862719012897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719012898 DNA binding site [nucleotide binding] 862719012899 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 862719012900 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 862719012901 Walker A/P-loop; other site 862719012902 ATP binding site [chemical binding]; other site 862719012903 Q-loop/lid; other site 862719012904 ABC transporter signature motif; other site 862719012905 Walker B; other site 862719012906 D-loop; other site 862719012907 H-loop/switch region; other site 862719012908 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 862719012909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012910 dimer interface [polypeptide binding]; other site 862719012911 conserved gate region; other site 862719012912 putative PBP binding loops; other site 862719012913 ABC-ATPase subunit interface; other site 862719012914 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 862719012915 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 862719012916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012917 dimer interface [polypeptide binding]; other site 862719012918 conserved gate region; other site 862719012919 putative PBP binding loops; other site 862719012920 ABC-ATPase subunit interface; other site 862719012921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719012922 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719012923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719012924 dimer interface [polypeptide binding]; other site 862719012925 phosphorylation site [posttranslational modification] 862719012926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012927 ATP binding site [chemical binding]; other site 862719012928 Mg2+ binding site [ion binding]; other site 862719012929 G-X-G motif; other site 862719012930 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 862719012931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719012932 non-specific DNA binding site [nucleotide binding]; other site 862719012933 salt bridge; other site 862719012934 sequence-specific DNA binding site [nucleotide binding]; other site 862719012935 Cupin domain; Region: Cupin_2; cl09118 862719012936 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719012937 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719012938 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 862719012939 Malic enzyme, N-terminal domain; Region: malic; pfam00390 862719012940 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 862719012941 putative NAD(P) binding site [chemical binding]; other site 862719012942 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862719012943 ribonuclease PH; Reviewed; Region: rph; PRK00173 862719012944 Ribonuclease PH; Region: RNase_PH_bact; cd11362 862719012945 hexamer interface [polypeptide binding]; other site 862719012946 active site 862719012947 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 862719012948 active site 862719012949 dimerization interface [polypeptide binding]; other site 862719012950 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 862719012951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719012952 FeS/SAM binding site; other site 862719012953 HemN C-terminal domain; Region: HemN_C; pfam06969 862719012954 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 862719012955 folate binding site [chemical binding]; other site 862719012956 NADP+ binding site [chemical binding]; other site 862719012957 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 862719012958 ParB-like nuclease domain; Region: ParBc; cl02129 862719012959 KorB domain; Region: KorB; pfam08535 862719012960 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719012961 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719012962 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719012963 Magnesium ion binding site [ion binding]; other site 862719012964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719012965 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 862719012966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012967 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 862719012968 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 862719012969 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 862719012970 trmE is a tRNA modification GTPase; Region: trmE; cd04164 862719012971 G1 box; other site 862719012972 GTP/Mg2+ binding site [chemical binding]; other site 862719012973 Switch I region; other site 862719012974 G2 box; other site 862719012975 Switch II region; other site 862719012976 G3 box; other site 862719012977 G4 box; other site 862719012978 G5 box; other site 862719012979 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 862719012980 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719012981 dimer interface [polypeptide binding]; other site 862719012982 [2Fe-2S] cluster binding site [ion binding]; other site 862719012983 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 862719012984 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 862719012985 catalytic residues [active] 862719012986 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 862719012987 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 862719012988 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 862719012989 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862719012990 DNA binding site [nucleotide binding] 862719012991 active site 862719012992 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 862719012993 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 862719012994 NADP binding site [chemical binding]; other site 862719012995 dimer interface [polypeptide binding]; other site 862719012996 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 862719012997 active site 862719012998 catalytic site [active] 862719012999 substrate binding site [chemical binding]; other site 862719013000 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 862719013001 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 862719013002 CoA-binding site [chemical binding]; other site 862719013003 ATP-binding [chemical binding]; other site 862719013004 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 862719013005 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 862719013006 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 862719013007 NAD(P) binding site [chemical binding]; other site 862719013008 shikimate binding site; other site 862719013009 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 862719013010 active site 862719013011 dimer interface [polypeptide binding]; other site 862719013012 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 862719013013 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 862719013014 substrate binding site [chemical binding]; other site 862719013015 active site 862719013016 ferrochelatase; Reviewed; Region: hemH; PRK00035 862719013017 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 862719013018 C-terminal domain interface [polypeptide binding]; other site 862719013019 active site 862719013020 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 862719013021 active site 862719013022 N-terminal domain interface [polypeptide binding]; other site 862719013023 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 862719013024 transcription termination factor Rho; Provisional; Region: rho; PRK09376 862719013025 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 862719013026 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 862719013027 RNA binding site [nucleotide binding]; other site 862719013028 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 862719013029 multimer interface [polypeptide binding]; other site 862719013030 Walker A motif; other site 862719013031 ATP binding site [chemical binding]; other site 862719013032 Walker B motif; other site 862719013033 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 862719013034 SecA binding site; other site 862719013035 Preprotein binding site; other site 862719013036 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 862719013037 Tim44-like domain; Region: Tim44; cl09208 862719013038 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 862719013039 MltA specific insert domain; Region: MltA; cl08398 862719013040 3D domain; Region: 3D; cl01439 862719013041 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 862719013042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013043 Walker A motif; other site 862719013044 ATP binding site [chemical binding]; other site 862719013045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719013047 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 862719013048 active site 862719013049 HslU subunit interaction site [polypeptide binding]; other site 862719013050 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719013051 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 862719013052 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 862719013053 putative active site pocket [active] 862719013054 4-fold oligomerization interface [polypeptide binding]; other site 862719013055 metal binding residues [ion binding]; metal-binding site 862719013056 3-fold/trimer interface [polypeptide binding]; other site 862719013057 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 862719013058 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 862719013059 putative active site [active] 862719013060 oxyanion strand; other site 862719013061 catalytic triad [active] 862719013062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719013063 Coenzyme A binding pocket [chemical binding]; other site 862719013064 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719013065 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 862719013066 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 862719013067 catalytic residues [active] 862719013068 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 862719013069 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 862719013070 substrate binding site [chemical binding]; other site 862719013071 glutamase interaction surface [polypeptide binding]; other site 862719013072 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 862719013073 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 862719013074 nucleotide binding site/active site [active] 862719013075 HIT family signature motif; other site 862719013076 catalytic residue [active] 862719013077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719013078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719013079 non-specific DNA binding site [nucleotide binding]; other site 862719013080 salt bridge; other site 862719013081 sequence-specific DNA binding site [nucleotide binding]; other site 862719013082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 862719013083 Smr domain; Region: Smr; cl02619 862719013084 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 862719013085 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 862719013086 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 862719013087 Cytochrome C biogenesis protein; Region: CcmH; cl01179 862719013088 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 862719013089 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 862719013090 catalytic residues [active] 862719013091 central insert; other site 862719013092 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 862719013093 CcmE; Region: CcmE; cl00994 862719013094 Heme exporter protein D (CcmD); Region: CcmD; cl11475 862719013095 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 862719013096 EVE domain; Region: EVE; cl00728 862719013097 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719013098 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 862719013099 putative dimer interface [polypeptide binding]; other site 862719013100 Helix-turn-helix domains; Region: HTH; cl00088 862719013101 WYL domain; Region: WYL; cl14852 862719013102 short chain dehydrogenase; Provisional; Region: PRK06123 862719013103 classical (c) SDRs; Region: SDR_c; cd05233 862719013104 NAD(P) binding site [chemical binding]; other site 862719013105 active site 862719013106 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 862719013107 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 862719013108 RNase E interface [polypeptide binding]; other site 862719013109 trimer interface [polypeptide binding]; other site 862719013110 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 862719013111 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 862719013112 RNase E interface [polypeptide binding]; other site 862719013113 trimer interface [polypeptide binding]; other site 862719013114 active site 862719013115 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 862719013116 putative nucleic acid binding region [nucleotide binding]; other site 862719013117 G-X-X-G motif; other site 862719013118 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 862719013119 RNA binding site [nucleotide binding]; other site 862719013120 domain interface; other site 862719013121 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 862719013122 16S/18S rRNA binding site [nucleotide binding]; other site 862719013123 S13e-L30e interaction site [polypeptide binding]; other site 862719013124 25S rRNA binding site [nucleotide binding]; other site 862719013125 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 862719013126 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 862719013127 RNA binding site [nucleotide binding]; other site 862719013128 active site 862719013129 Ribosome-binding factor A; Region: RBFA; cl00542 862719013130 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 862719013131 putative active site [active] 862719013132 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719013133 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 862719013134 translation initiation factor IF-2; Region: IF-2; TIGR00487 862719013135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 862719013136 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 862719013137 G1 box; other site 862719013138 putative GEF interaction site [polypeptide binding]; other site 862719013139 GTP/Mg2+ binding site [chemical binding]; other site 862719013140 Switch I region; other site 862719013141 G2 box; other site 862719013142 G3 box; other site 862719013143 Switch II region; other site 862719013144 G4 box; other site 862719013145 G5 box; other site 862719013146 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 862719013147 Translation-initiation factor 2; Region: IF-2; pfam11987 862719013148 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 862719013149 hypothetical protein; Provisional; Region: PRK09190 862719013150 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 862719013151 putative RNA binding cleft [nucleotide binding]; other site 862719013152 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 862719013153 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 862719013154 NusA N-terminal domain; Region: NusA_N; pfam08529 862719013155 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 862719013156 RNA binding site [nucleotide binding]; other site 862719013157 homodimer interface [polypeptide binding]; other site 862719013158 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 862719013159 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 862719013160 G-X-X-G motif; other site 862719013161 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 862719013162 ribosome maturation protein RimP; Reviewed; Region: PRK00092 862719013163 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 862719013164 Sm1 motif; other site 862719013165 D1 - D2 interaction site; other site 862719013166 D3 - B interaction site; other site 862719013167 Hfq - Hfq interaction site; other site 862719013168 RNA binding pocket [nucleotide binding]; other site 862719013169 Sm2 motif; other site 862719013170 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 862719013171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862719013172 S-adenosylmethionine synthetase; Validated; Region: PRK05250 862719013173 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 862719013174 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 862719013175 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 862719013176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719013177 non-specific DNA binding site [nucleotide binding]; other site 862719013178 salt bridge; other site 862719013179 sequence-specific DNA binding site [nucleotide binding]; other site 862719013180 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 862719013181 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 862719013182 putative active site [active] 862719013183 catalytic triad [active] 862719013184 putative dimer interface [polypeptide binding]; other site 862719013185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862719013186 Transporter associated domain; Region: CorC_HlyC; cl08393 862719013187 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 862719013188 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 862719013189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013190 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 862719013191 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862719013192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719013193 FeS/SAM binding site; other site 862719013194 Predicted acetyltransferase [General function prediction only]; Region: COG3153 862719013195 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719013196 Protein of unknown function (DUF525); Region: DUF525; cl01119 862719013197 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 862719013198 homodecamer interface [polypeptide binding]; other site 862719013199 GTP cyclohydrolase I; Provisional; Region: PLN03044 862719013200 active site 862719013201 putative catalytic site residues [active] 862719013202 zinc binding site [ion binding]; other site 862719013203 GTP-CH-I/GFRP interaction surface; other site 862719013204 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 862719013205 putative deacylase active site [active] 862719013206 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 862719013207 Moco binding site; other site 862719013208 metal coordination site [ion binding]; other site 862719013209 putative mechanosensitive channel protein; Provisional; Region: PRK11465 862719013210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719013211 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 862719013212 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 862719013213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719013214 minor groove reading motif; other site 862719013215 helix-hairpin-helix signature motif; other site 862719013216 substrate binding pocket [chemical binding]; other site 862719013217 active site 862719013218 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 862719013219 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 862719013220 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 862719013221 adenosine kinase; Provisional; Region: PTZ00247 862719013222 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 862719013223 substrate binding site [chemical binding]; other site 862719013224 ATP binding site [chemical binding]; other site 862719013225 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 862719013226 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 862719013227 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719013228 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 862719013229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719013230 Ligand Binding Site [chemical binding]; other site 862719013231 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 862719013232 NifU-like domain; Region: NifU; cl00484 862719013233 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 862719013234 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013236 active site 862719013237 phosphorylation site [posttranslational modification] 862719013238 intermolecular recognition site; other site 862719013239 dimerization interface [polypeptide binding]; other site 862719013240 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 862719013241 dimer interface [polypeptide binding]; other site 862719013242 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 862719013243 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 862719013244 Helix-turn-helix domains; Region: HTH; cl00088 862719013245 HrcA protein C terminal domain; Region: HrcA; pfam01628 862719013246 Creatinine amidohydrolase; Region: Creatininase; cl00618 862719013247 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 862719013248 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 862719013249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013250 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 862719013251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719013252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719013253 Helix-turn-helix domains; Region: HTH; cl00088 862719013254 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 862719013255 putative substrate binding pocket [chemical binding]; other site 862719013256 AC domain interface; other site 862719013257 catalytic triad [active] 862719013258 AB domain interface; other site 862719013259 interchain disulfide; other site 862719013260 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 862719013261 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 862719013262 active site 862719013263 HIGH motif; other site 862719013264 dimer interface [polypeptide binding]; other site 862719013265 KMSKS motif; other site 862719013266 glutathione synthetase; Provisional; Region: PRK05246 862719013267 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 862719013268 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719013269 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 862719013270 Tetratricopeptide repeat; Region: TPR_9; pfam13371 862719013271 Restriction endonuclease; Region: Mrr_cat; cl00516 862719013272 Predicted methyltransferases [General function prediction only]; Region: COG0313 862719013273 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 862719013274 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719013275 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 862719013276 putative ligand binding site [chemical binding]; other site 862719013277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013278 dimer interface [polypeptide binding]; other site 862719013279 conserved gate region; other site 862719013280 putative PBP binding loops; other site 862719013281 ABC-ATPase subunit interface; other site 862719013282 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719013283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013284 dimer interface [polypeptide binding]; other site 862719013285 conserved gate region; other site 862719013286 putative PBP binding loops; other site 862719013287 ABC-ATPase subunit interface; other site 862719013288 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719013289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719013290 substrate binding pocket [chemical binding]; other site 862719013291 membrane-bound complex binding site; other site 862719013292 hinge residues; other site 862719013293 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 862719013294 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 862719013295 Walker A/P-loop; other site 862719013296 ATP binding site [chemical binding]; other site 862719013297 Q-loop/lid; other site 862719013298 ABC transporter signature motif; other site 862719013299 Walker B; other site 862719013300 D-loop; other site 862719013301 H-loop/switch region; other site 862719013302 putative transporter; Validated; Region: PRK03818 862719013303 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 862719013304 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013305 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013306 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 862719013307 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 862719013308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013309 Walker A/P-loop; other site 862719013310 ATP binding site [chemical binding]; other site 862719013311 Q-loop/lid; other site 862719013312 ABC transporter signature motif; other site 862719013313 Walker B; other site 862719013314 D-loop; other site 862719013315 H-loop/switch region; other site 862719013316 CcmB protein; Region: CcmB; cl01016 862719013317 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 862719013318 catalytic residues [active] 862719013319 dimer interface [polypeptide binding]; other site 862719013320 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 862719013321 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719013322 putative peptidase; Provisional; Region: PRK11649 862719013323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719013324 binding surface 862719013325 TPR motif; other site 862719013326 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 862719013327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719013328 binding surface 862719013329 TPR motif; other site 862719013330 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719013331 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719013332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719013333 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862719013334 putative active site [active] 862719013335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013337 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862719013338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013339 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 862719013340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013341 Mg2+ binding site [ion binding]; other site 862719013342 G-X-G motif; other site 862719013343 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862719013344 anchoring element; other site 862719013345 dimer interface [polypeptide binding]; other site 862719013346 ATP binding site [chemical binding]; other site 862719013347 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862719013348 active site 862719013349 putative metal-binding site [ion binding]; other site 862719013350 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862719013351 recombination protein F; Reviewed; Region: recF; PRK00064 862719013352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013353 Walker A/P-loop; other site 862719013354 ATP binding site [chemical binding]; other site 862719013355 Q-loop/lid; other site 862719013356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013357 ABC transporter signature motif; other site 862719013358 Walker B; other site 862719013359 D-loop; other site 862719013360 H-loop/switch region; other site 862719013361 DNA polymerase III subunit beta; Validated; Region: PRK05643 862719013362 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 862719013363 putative DNA binding surface [nucleotide binding]; other site 862719013364 dimer interface [polypeptide binding]; other site 862719013365 beta-clamp/clamp loader binding surface; other site 862719013366 beta-clamp/translesion DNA polymerase binding surface; other site 862719013367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719013368 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 862719013369 putative NAD(P) binding site [chemical binding]; other site 862719013370 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 862719013371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719013372 binding surface 862719013373 TPR motif; other site 862719013374 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862719013375 catalytic residues [active] 862719013376 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 862719013377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013378 Family description; Region: UvrD_C_2; cl15862 862719013379 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719013380 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 862719013381 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 862719013382 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719013383 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 862719013384 Substrate binding site; other site 862719013385 metal-binding site 862719013386 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719013387 Phosphotransferase enzyme family; Region: APH; pfam01636 862719013388 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 862719013389 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862719013390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719013392 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 862719013393 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719013394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719013395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013396 ABC-ATPase subunit interface; other site 862719013397 putative PBP binding loops; other site 862719013398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719013399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719013400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719013401 active site 862719013402 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 862719013403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719013404 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 862719013405 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 862719013406 DNA binding site [nucleotide binding] 862719013407 catalytic residue [active] 862719013408 H2TH interface [polypeptide binding]; other site 862719013409 putative catalytic residues [active] 862719013410 turnover-facilitating residue; other site 862719013411 intercalation triad [nucleotide binding]; other site 862719013412 8OG recognition residue [nucleotide binding]; other site 862719013413 putative reading head residues; other site 862719013414 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 862719013415 enoyl-CoA hydratase; Provisional; Region: PRK05862 862719013416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719013417 substrate binding site [chemical binding]; other site 862719013418 oxyanion hole (OAH) forming residues; other site 862719013419 trimer interface [polypeptide binding]; other site 862719013420 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013421 transmembrane helices; other site 862719013422 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013423 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013424 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013425 FOG: CBS domain [General function prediction only]; Region: COG0517 862719013426 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 862719013427 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719013428 putative metal binding site [ion binding]; other site 862719013429 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013431 active site 862719013432 phosphorylation site [posttranslational modification] 862719013433 intermolecular recognition site; other site 862719013434 dimerization interface [polypeptide binding]; other site 862719013435 GAF domain; Region: GAF_2; pfam13185 862719013436 GAF domain; Region: GAF; cl15785 862719013437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013438 PAS domain; Region: PAS_9; pfam13426 862719013439 putative active site [active] 862719013440 heme pocket [chemical binding]; other site 862719013441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013442 PAS fold; Region: PAS_3; pfam08447 862719013443 putative active site [active] 862719013444 heme pocket [chemical binding]; other site 862719013445 PAS domain S-box; Region: sensory_box; TIGR00229 862719013446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013447 putative active site [active] 862719013448 heme pocket [chemical binding]; other site 862719013449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013450 PAS fold; Region: PAS_3; pfam08447 862719013451 putative active site [active] 862719013452 heme pocket [chemical binding]; other site 862719013453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013454 dimer interface [polypeptide binding]; other site 862719013455 phosphorylation site [posttranslational modification] 862719013456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013457 ATP binding site [chemical binding]; other site 862719013458 Mg2+ binding site [ion binding]; other site 862719013459 G-X-G motif; other site 862719013460 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013462 active site 862719013463 phosphorylation site [posttranslational modification] 862719013464 intermolecular recognition site; other site 862719013465 dimerization interface [polypeptide binding]; other site 862719013466 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719013467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013468 active site 862719013469 phosphorylation site [posttranslational modification] 862719013470 intermolecular recognition site; other site 862719013471 dimerization interface [polypeptide binding]; other site 862719013472 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 862719013473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719013474 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719013475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013476 Walker A/P-loop; other site 862719013477 ATP binding site [chemical binding]; other site 862719013478 Q-loop/lid; other site 862719013479 ABC transporter signature motif; other site 862719013480 Walker B; other site 862719013481 D-loop; other site 862719013482 H-loop/switch region; other site 862719013483 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 862719013484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013485 UDP-galactopyranose mutase; Region: GLF; pfam03275 862719013486 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 862719013487 putative homodimer interface [polypeptide binding]; other site 862719013488 HupF/HypC family; Region: HupF_HypC; cl00394 862719013489 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 862719013490 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 862719013491 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 862719013492 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 862719013493 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 862719013494 nickel binding site [ion binding]; other site 862719013495 Formate hydrogenlyase maturation protein HycH; Region: HycH; cl06472 862719013496 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 862719013497 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 862719013498 4Fe-4S binding domain; Region: Fer4; cl02805 862719013499 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 862719013500 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 862719013501 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 862719013502 hydrogenase 4 subunit F; Validated; Region: PRK06458 862719013503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719013504 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 862719013505 hydrogenase 4 subunit D; Validated; Region: PRK06525 862719013506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719013507 NADH dehydrogenase; Region: NADHdh; cl00469 862719013508 hydrogenase 4 subunit B; Validated; Region: PRK06521 862719013509 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 862719013510 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 862719013511 4Fe-4S binding domain; Region: Fer4; cl02805 862719013512 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 862719013513 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 862719013514 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719013515 [4Fe-4S] binding site [ion binding]; other site 862719013516 molybdopterin cofactor binding site; other site 862719013517 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 862719013518 molybdopterin cofactor binding site; other site 862719013519 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor 862719013520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719013521 Helix-turn-helix domains; Region: HTH; cl00088 862719013522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719013523 dimerization interface [polypeptide binding]; other site 862719013524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862719013525 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719013526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013527 active site 862719013528 phosphorylation site [posttranslational modification] 862719013529 intermolecular recognition site; other site 862719013530 dimerization interface [polypeptide binding]; other site 862719013531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013532 Walker A motif; other site 862719013533 ATP binding site [chemical binding]; other site 862719013534 Walker B motif; other site 862719013535 arginine finger; other site 862719013536 Helix-turn-helix domains; Region: HTH; cl00088 862719013537 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3671068; Product type pe : putative enzyme 862719013538 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719013539 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 862719013540 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 862719013541 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 862719013542 Aspartase; Region: Aspartase; cd01357 862719013543 active sites [active] 862719013544 tetramer interface [polypeptide binding]; other site 862719013545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719013546 ornithine decarboxylase; Provisional; Region: PRK13578 862719013547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719013548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719013549 catalytic residue [active] 862719013550 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 862719013551 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719013552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719013553 Coenzyme A binding pocket [chemical binding]; other site 862719013554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 862719013555 MOSC domain; Region: MOSC; pfam03473 862719013556 3-alpha domain; Region: 3-alpha; pfam03475 862719013557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719013558 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 862719013559 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719013560 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719013561 Fusaric acid resistance protein family; Region: FUSC; pfam04632 862719013562 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 862719013563 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 862719013564 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719013565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013566 putative active site [active] 862719013567 heme pocket [chemical binding]; other site 862719013568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013569 dimer interface [polypeptide binding]; other site 862719013570 phosphorylation site [posttranslational modification] 862719013571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013572 ATP binding site [chemical binding]; other site 862719013573 Mg2+ binding site [ion binding]; other site 862719013574 G-X-G motif; other site 862719013575 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 862719013576 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 862719013577 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 862719013578 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 862719013579 putative substrate-binding site; other site 862719013580 nickel binding site [ion binding]; other site 862719013581 HupF/HypC family; Region: HupF_HypC; cl00394 862719013582 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 862719013583 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 862719013584 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 862719013585 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 862719013586 Rubredoxin; Region: Rubredoxin; pfam00301 862719013587 iron binding site [ion binding]; other site 862719013588 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 862719013589 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 862719013590 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 862719013591 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719013592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013593 active site 862719013594 phosphorylation site [posttranslational modification] 862719013595 intermolecular recognition site; other site 862719013596 dimerization interface [polypeptide binding]; other site 862719013597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013598 Walker A motif; other site 862719013599 ATP binding site [chemical binding]; other site 862719013600 Walker B motif; other site 862719013601 arginine finger; other site 862719013602 Helix-turn-helix domains; Region: HTH; cl00088 862719013603 HupE / UreJ protein; Region: HupE_UreJ; cl01011 862719013604 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 862719013605 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 862719013606 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 862719013607 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 862719013608 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719013609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013611 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 862719013612 Acylphosphatase; Region: Acylphosphatase; cl00551 862719013613 HypF finger; Region: zf-HYPF; pfam07503 862719013614 HypF finger; Region: zf-HYPF; pfam07503 862719013615 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 862719013616 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 862719013617 Sulfate transporter family; Region: Sulfate_transp; cl15842 862719013618 Sulfate transporter family; Region: Sulfate_transp; cl15842 862719013619 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 862719013620 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 862719013621 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 862719013622 malonyl-CoA binding site [chemical binding]; other site 862719013623 dimer interface [polypeptide binding]; other site 862719013624 active site 862719013625 product binding site; other site 862719013626 Phospholipid methyltransferase; Region: PEMT; cl00763 862719013627 short chain dehydrogenase; Provisional; Region: PRK06181 862719013628 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 862719013629 putative NAD(P) binding site [chemical binding]; other site 862719013630 active site 862719013631 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719013632 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719013633 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719013634 DctM-like transporters; Region: DctM; pfam06808 862719013635 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719013636 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719013637 putative active site [active] 862719013638 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 862719013639 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719013640 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 862719013641 MPT binding site; other site 862719013642 trimer interface [polypeptide binding]; other site 862719013643 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 862719013644 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 862719013645 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 862719013646 metal ion-dependent adhesion site (MIDAS); other site 862719013647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719013648 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 862719013649 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 862719013650 Low-spin heme binding site [chemical binding]; other site 862719013651 D-pathway; other site 862719013652 K-pathway; other site 862719013653 Binuclear center (active site) [active] 862719013654 Putative proton exit pathway; other site 862719013655 Putative water exit pathway; other site 862719013656 Cytochrome c; Region: Cytochrom_C; cl11414 862719013657 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 862719013658 Subunit I/III interface [polypeptide binding]; other site 862719013659 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 862719013660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719013661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013662 homodimer interface [polypeptide binding]; other site 862719013663 catalytic residue [active] 862719013664 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719013665 hypothetical protein; Provisional; Region: PRK01617 862719013666 SEC-C motif; Region: SEC-C; pfam02810 862719013667 SEC-C motif; Region: SEC-C; pfam02810 862719013668 Transposase domain (DUF772); Region: DUF772; cl15789 862719013669 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719013670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719013671 Zn2+ binding site [ion binding]; other site 862719013672 Mg2+ binding site [ion binding]; other site 862719013673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719013674 Helix-turn-helix domains; Region: HTH; cl00088 862719013675 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719013676 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719013677 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719013678 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719013679 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 862719013680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013681 S-adenosylmethionine binding site [chemical binding]; other site 862719013682 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 862719013683 Erythromycin esterase; Region: Erythro_esteras; pfam05139 862719013684 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 862719013685 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 862719013686 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719013687 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 862719013688 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719013689 DctM-like transporters; Region: DctM; pfam06808 862719013690 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719013691 NMT1-like family; Region: NMT1_2; cl15260 862719013692 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 862719013693 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719013694 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719013695 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 862719013696 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719013697 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719013698 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 862719013699 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 862719013700 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 862719013701 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 862719013702 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719013703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013704 Walker A motif; other site 862719013705 ATP binding site [chemical binding]; other site 862719013706 Walker B motif; other site 862719013707 arginine finger; other site 862719013708 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 862719013709 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719013710 metal ion-dependent adhesion site (MIDAS); other site 862719013711 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 862719013712 XdhC Rossmann domain; Region: XdhC_C; pfam13478 862719013713 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 862719013714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719013715 dimer interface [polypeptide binding]; other site 862719013716 phosphorylation site [posttranslational modification] 862719013717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013718 ATP binding site [chemical binding]; other site 862719013719 Mg2+ binding site [ion binding]; other site 862719013720 G-X-G motif; other site 862719013721 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719013722 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 862719013723 peptide binding site [polypeptide binding]; other site 862719013724 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719013725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719013726 PAS fold; Region: PAS; pfam00989 862719013727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719013728 metal binding site [ion binding]; metal-binding site 862719013729 active site 862719013730 I-site; other site 862719013731 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 862719013732 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862719013733 tetramer interface [polypeptide binding]; other site 862719013734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013735 catalytic residue [active] 862719013736 Predicted transcriptional regulator [Transcription]; Region: COG4190 862719013737 Helix-turn-helix domains; Region: HTH; cl00088 862719013738 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719013739 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719013740 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 862719013741 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 862719013742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719013743 active site 862719013744 metal binding site [ion binding]; metal-binding site 862719013745 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862719013746 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 862719013747 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 862719013748 catalytic triad [active] 862719013749 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 862719013750 putative MPT binding site; other site 862719013751 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 862719013752 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 862719013753 Ligand binding site; other site 862719013754 metal-binding site 862719013755 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 862719013756 NMT1-like family; Region: NMT1_2; cl15260 862719013757 transcriptional regulator BetI; Validated; Region: PRK00767 862719013758 Helix-turn-helix domains; Region: HTH; cl00088 862719013759 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 862719013760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013761 dimer interface [polypeptide binding]; other site 862719013762 conserved gate region; other site 862719013763 putative PBP binding loops; other site 862719013764 ABC-ATPase subunit interface; other site 862719013765 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719013766 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 862719013767 Walker A/P-loop; other site 862719013768 ATP binding site [chemical binding]; other site 862719013769 Q-loop/lid; other site 862719013770 ABC transporter signature motif; other site 862719013771 Walker B; other site 862719013772 D-loop; other site 862719013773 H-loop/switch region; other site 862719013774 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719013775 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 862719013776 heme-binding site [chemical binding]; other site 862719013777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719013779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013780 dimer interface [polypeptide binding]; other site 862719013781 putative CheW interface [polypeptide binding]; other site 862719013782 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 862719013783 Putative ammonia monooxygenase; Region: AmoA; pfam05145 862719013784 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 862719013785 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 862719013786 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719013787 homodimer interface [polypeptide binding]; other site 862719013788 substrate-cofactor binding pocket; other site 862719013789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013790 catalytic residue [active] 862719013791 Imelysin; Region: Peptidase_M75; cl09159 862719013792 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719013793 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719013794 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719013795 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 862719013796 Imelysin; Region: Peptidase_M75; cl09159 862719013797 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 862719013798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719013799 Predicted esterase [General function prediction only]; Region: COG0627 862719013800 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 862719013801 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 862719013802 substrate binding site [chemical binding]; other site 862719013803 catalytic Zn binding site [ion binding]; other site 862719013804 NAD binding site [chemical binding]; other site 862719013805 structural Zn binding site [ion binding]; other site 862719013806 dimer interface [polypeptide binding]; other site 862719013807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719013808 Helix-turn-helix domains; Region: HTH; cl00088 862719013809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719013810 dimerization interface [polypeptide binding]; other site 862719013811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 862719013812 Protein of unknown function (DUF330); Region: DUF330; cl01135 862719013813 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 862719013814 mce related protein; Region: MCE; pfam02470 862719013815 mce related protein; Region: MCE; pfam02470 862719013816 mce related protein; Region: MCE; pfam02470 862719013817 Paraquat-inducible protein A; Region: PqiA; pfam04403 862719013818 Paraquat-inducible protein A; Region: PqiA; pfam04403 862719013819 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 862719013820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719013821 DNA-binding site [nucleotide binding]; DNA binding site 862719013822 UTRA domain; Region: UTRA; cl01230 862719013823 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719013824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719013825 substrate binding pocket [chemical binding]; other site 862719013826 membrane-bound complex binding site; other site 862719013827 hinge residues; other site 862719013828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719013829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013830 dimer interface [polypeptide binding]; other site 862719013831 ABC-ATPase subunit interface; other site 862719013832 putative PBP binding loops; other site 862719013833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719013834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719013835 dimer interface [polypeptide binding]; other site 862719013836 conserved gate region; other site 862719013837 putative PBP binding loops; other site 862719013838 ABC-ATPase subunit interface; other site 862719013839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719013840 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 862719013841 Walker A/P-loop; other site 862719013842 ATP binding site [chemical binding]; other site 862719013843 Q-loop/lid; other site 862719013844 ABC transporter signature motif; other site 862719013845 Walker B; other site 862719013846 D-loop; other site 862719013847 H-loop/switch region; other site 862719013848 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719013849 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719013850 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 862719013851 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 862719013852 Walker A/P-loop; other site 862719013853 ATP binding site [chemical binding]; other site 862719013854 Q-loop/lid; other site 862719013855 ABC transporter signature motif; other site 862719013856 Walker B; other site 862719013857 D-loop; other site 862719013858 H-loop/switch region; other site 862719013859 Cobalt transport protein; Region: CbiQ; cl00463 862719013860 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719013861 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719013862 AMP-binding enzyme; Region: AMP-binding; cl15778 862719013863 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719013864 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 862719013865 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719013866 dimer interface [polypeptide binding]; other site 862719013867 active site 862719013868 H+ Antiporter protein; Region: 2A0121; TIGR00900 862719013869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719013870 putative substrate translocation pore; other site 862719013871 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 862719013872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719013873 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719013874 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013876 active site 862719013877 phosphorylation site [posttranslational modification] 862719013878 intermolecular recognition site; other site 862719013879 dimerization interface [polypeptide binding]; other site 862719013880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013881 PAS fold; Region: PAS_3; pfam08447 862719013882 putative active site [active] 862719013883 heme pocket [chemical binding]; other site 862719013884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719013885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013886 dimer interface [polypeptide binding]; other site 862719013887 phosphorylation site [posttranslational modification] 862719013888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013889 ATP binding site [chemical binding]; other site 862719013890 Mg2+ binding site [ion binding]; other site 862719013891 G-X-G motif; other site 862719013892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719013893 phosphorylation site [posttranslational modification] 862719013894 intermolecular recognition site; other site 862719013895 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719013896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013905 GAF domain; Region: GAF_2; pfam13185 862719013906 GAF domain; Region: GAF; cl15785 862719013907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719013908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013909 ATP binding site [chemical binding]; other site 862719013910 Mg2+ binding site [ion binding]; other site 862719013911 G-X-G motif; other site 862719013912 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013914 active site 862719013915 phosphorylation site [posttranslational modification] 862719013916 intermolecular recognition site; other site 862719013917 dimerization interface [polypeptide binding]; other site 862719013918 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719013919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013920 active site 862719013921 phosphorylation site [posttranslational modification] 862719013922 intermolecular recognition site; other site 862719013923 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013925 active site 862719013926 phosphorylation site [posttranslational modification] 862719013927 intermolecular recognition site; other site 862719013928 dimerization interface [polypeptide binding]; other site 862719013929 TMAO/DMSO reductase; Reviewed; Region: PRK05363 862719013930 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 862719013931 Moco binding site; other site 862719013932 metal coordination site [ion binding]; other site 862719013933 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 862719013934 Dienelactone hydrolase family; Region: DLH; pfam01738 862719013935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719013936 Helix-turn-helix domains; Region: HTH; cl00088 862719013937 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862719013938 dimerization interface [polypeptide binding]; other site 862719013939 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 862719013940 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 862719013941 dimer interface [polypeptide binding]; other site 862719013942 active site 862719013943 heme binding site [chemical binding]; other site 862719013944 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 862719013945 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 862719013946 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 862719013947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 862719013948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013949 S-adenosylmethionine binding site [chemical binding]; other site 862719013950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719013951 Histidine kinase; Region: HisKA_2; cl06527 862719013952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013953 ATP binding site [chemical binding]; other site 862719013954 Mg2+ binding site [ion binding]; other site 862719013955 G-X-G motif; other site 862719013956 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 862719013957 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 862719013958 TPP-binding site; other site 862719013959 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719013960 PYR/PP interface [polypeptide binding]; other site 862719013961 dimer interface [polypeptide binding]; other site 862719013962 TPP binding site [chemical binding]; other site 862719013963 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719013964 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 862719013965 substrate binding pocket [chemical binding]; other site 862719013966 chain length determination region; other site 862719013967 substrate-Mg2+ binding site; other site 862719013968 catalytic residues [active] 862719013969 aspartate-rich region 1; other site 862719013970 active site lid residues [active] 862719013971 aspartate-rich region 2; other site 862719013972 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 862719013973 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719013974 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 862719013975 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 862719013976 CPxP motif; other site 862719013977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719013978 dimerization interface [polypeptide binding]; other site 862719013979 putative DNA binding site [nucleotide binding]; other site 862719013980 putative Zn2+ binding site [ion binding]; other site 862719013981 Protein of unknown function (DUF423); Region: DUF423; cl01008 862719013982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719013983 active site 862719013984 Amidase; Region: Amidase; cl11426 862719013985 Protein of unknown function DUF262; Region: DUF262; cl14890 862719013986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719013987 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719013988 NAD(P) binding site [chemical binding]; other site 862719013989 active site 862719013990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 862719013991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719013992 catalytic residue [active] 862719013993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719013994 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 862719013995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719013996 PAS domain S-box; Region: sensory_box; TIGR00229 862719013997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013998 putative active site [active] 862719013999 heme pocket [chemical binding]; other site 862719014000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014001 PAS domain; Region: PAS_9; pfam13426 862719014002 putative active site [active] 862719014003 heme pocket [chemical binding]; other site 862719014004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014005 metal binding site [ion binding]; metal-binding site 862719014006 active site 862719014007 I-site; other site 862719014008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014009 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 862719014010 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719014011 active site 862719014012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719014013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719014014 active site 862719014015 ATP binding site [chemical binding]; other site 862719014016 substrate binding site [chemical binding]; other site 862719014017 activation loop (A-loop); other site 862719014018 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719014019 Zinc-finger domain; Region: zf-CHCC; cl01821 862719014020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719014021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014022 Walker A/P-loop; other site 862719014023 ATP binding site [chemical binding]; other site 862719014024 Q-loop/lid; other site 862719014025 ABC transporter signature motif; other site 862719014026 Walker B; other site 862719014027 D-loop; other site 862719014028 H-loop/switch region; other site 862719014029 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862719014030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719014031 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719014032 active site 862719014033 catalytic site [active] 862719014034 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 862719014035 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 862719014036 active site 862719014037 homodimer interface [polypeptide binding]; other site 862719014038 catalytic site [active] 862719014039 acceptor binding site [chemical binding]; other site 862719014040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014041 active site 862719014042 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719014043 aspartate racemase; Region: asp_race; TIGR00035 862719014044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719014045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014046 active site 862719014047 phosphorylation site [posttranslational modification] 862719014048 intermolecular recognition site; other site 862719014049 dimerization interface [polypeptide binding]; other site 862719014050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719014051 DNA binding residues [nucleotide binding] 862719014052 dimerization interface [polypeptide binding]; other site 862719014053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014054 PAS domain; Region: PAS_9; pfam13426 862719014055 putative active site [active] 862719014056 heme pocket [chemical binding]; other site 862719014057 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862719014058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719014059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014060 ATP binding site [chemical binding]; other site 862719014061 Mg2+ binding site [ion binding]; other site 862719014062 G-X-G motif; other site 862719014063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719014065 PAS domain; Region: PAS_9; pfam13426 862719014066 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 862719014067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719014068 PAS domain; Region: PAS_9; pfam13426 862719014069 CheB methylesterase; Region: CheB_methylest; pfam01339 862719014070 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719014071 dinuclear metal binding motif [ion binding]; other site 862719014072 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719014073 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719014074 putative metal binding site [ion binding]; other site 862719014075 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 862719014076 Protein of unknown function (DUF421); Region: DUF421; cl00990 862719014077 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 862719014078 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862719014079 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862719014080 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 862719014081 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 862719014082 Surface antigen; Region: Bac_surface_Ag; cl03097 862719014083 CHASE2 domain; Region: CHASE2; cl01732 862719014084 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 862719014085 cyclase homology domain; Region: CHD; cd07302 862719014086 nucleotidyl binding site; other site 862719014087 metal binding site [ion binding]; metal-binding site 862719014088 dimer interface [polypeptide binding]; other site 862719014089 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719014090 PhoU domain; Region: PhoU; pfam01895 862719014091 PhoU domain; Region: PhoU; pfam01895 862719014092 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 862719014093 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 862719014094 motif 1; other site 862719014095 dimer interface [polypeptide binding]; other site 862719014096 active site 862719014097 motif 2; other site 862719014098 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 862719014099 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 862719014100 GDP-binding site [chemical binding]; other site 862719014101 ACT binding site; other site 862719014102 IMP binding site; other site 862719014103 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719014104 Helix-turn-helix domains; Region: HTH; cl00088 862719014105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719014106 ParB-like partition proteins; Region: parB_part; TIGR00180 862719014107 ParB-like nuclease domain; Region: ParBc; cl02129 862719014108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014109 S-adenosylmethionine binding site [chemical binding]; other site 862719014110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014111 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719014112 active site 862719014113 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 862719014114 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 862719014115 Helix-turn-helix domains; Region: HTH; cl00088 862719014116 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 862719014117 putative ABC transporter; Region: ycf24; CHL00085 862719014118 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 862719014119 GIY-YIG motif/motif A; other site 862719014120 putative active site [active] 862719014121 putative metal binding site [ion binding]; other site 862719014122 FeS assembly ATPase SufC; Region: sufC; TIGR01978 862719014123 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 862719014124 Walker A/P-loop; other site 862719014125 ATP binding site [chemical binding]; other site 862719014126 Q-loop/lid; other site 862719014127 ABC transporter signature motif; other site 862719014128 Walker B; other site 862719014129 D-loop; other site 862719014130 H-loop/switch region; other site 862719014131 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 862719014132 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 862719014133 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 862719014134 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 862719014135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719014136 catalytic residue [active] 862719014137 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 862719014138 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 862719014139 trimerization site [polypeptide binding]; other site 862719014140 active site 862719014141 Domain of unknown function DUF59; Region: DUF59; cl00941 862719014142 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 862719014143 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719014144 Helix-turn-helix domains; Region: HTH; cl00088 862719014145 Helix-turn-helix domains; Region: HTH; cl00088 862719014146 Pirin-related protein [General function prediction only]; Region: COG1741 862719014147 Cupin domain; Region: Cupin_2; cl09118 862719014148 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 862719014149 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 862719014150 PAS fold; Region: PAS; pfam00989 862719014151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014152 putative active site [active] 862719014153 heme pocket [chemical binding]; other site 862719014154 PAS domain S-box; Region: sensory_box; TIGR00229 862719014155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014156 putative active site [active] 862719014157 heme pocket [chemical binding]; other site 862719014158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014159 metal binding site [ion binding]; metal-binding site 862719014160 active site 862719014161 I-site; other site 862719014162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014163 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 862719014164 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 862719014165 dimerization interface [polypeptide binding]; other site 862719014166 ligand binding site [chemical binding]; other site 862719014167 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719014168 Helix-turn-helix domains; Region: HTH; cl00088 862719014169 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719014170 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 862719014171 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 862719014172 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 862719014173 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 862719014174 active site 862719014175 intersubunit interface [polypeptide binding]; other site 862719014176 catalytic residue [active] 862719014177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719014178 NMT1-like family; Region: NMT1_2; cl15260 862719014179 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 862719014180 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 862719014181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719014182 classical (c) SDRs; Region: SDR_c; cd05233 862719014183 NAD(P) binding site [chemical binding]; other site 862719014184 active site 862719014185 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719014186 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719014187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719014188 non-specific DNA binding site [nucleotide binding]; other site 862719014189 salt bridge; other site 862719014190 sequence-specific DNA binding site [nucleotide binding]; other site 862719014191 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 862719014192 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 862719014193 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 862719014194 substrate binding site [chemical binding]; other site 862719014195 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 862719014196 substrate binding site [chemical binding]; other site 862719014197 ligand binding site [chemical binding]; other site 862719014198 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 862719014199 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719014200 EamA-like transporter family; Region: EamA; cl01037 862719014201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719014202 FeS/SAM binding site; other site 862719014203 Arginase family; Region: Arginase; cl00306 862719014204 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 862719014205 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719014206 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719014207 putative active site [active] 862719014208 Pyruvate formate lyase 1; Region: PFL1; cd01678 862719014209 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 862719014210 coenzyme A binding site [chemical binding]; other site 862719014211 active site 862719014212 catalytic residues [active] 862719014213 glycine loop; other site 862719014214 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 862719014215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719014216 FeS/SAM binding site; other site 862719014217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 862719014218 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719014219 FAD binding domain; Region: FAD_binding_4; pfam01565 862719014220 Berberine and berberine like; Region: BBE; pfam08031 862719014221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719014222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719014223 DNA binding site [nucleotide binding] 862719014224 domain linker motif; other site 862719014225 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 862719014226 putative dimerization interface [polypeptide binding]; other site 862719014227 putative ligand binding site [chemical binding]; other site 862719014228 altronate oxidoreductase; Provisional; Region: PRK03643 862719014229 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719014230 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719014231 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 862719014232 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719014233 dimer interface [polypeptide binding]; other site 862719014234 PYR/PP interface [polypeptide binding]; other site 862719014235 TPP binding site [chemical binding]; other site 862719014236 substrate binding site [chemical binding]; other site 862719014237 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 862719014238 Domain of unknown function; Region: EKR; cl11037 862719014239 4Fe-4S binding domain; Region: Fer4; cl02805 862719014240 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 862719014241 TPP-binding site [chemical binding]; other site 862719014242 dimer interface [polypeptide binding]; other site 862719014243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719014244 D-galactonate transporter; Region: 2A0114; TIGR00893 862719014245 putative substrate translocation pore; other site 862719014246 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719014247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719014248 motif II; other site 862719014249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719014250 Helix-turn-helix domains; Region: HTH; cl00088 862719014251 alpha-amylase; Reviewed; Region: malS; PRK09505 862719014252 Hemolysin-type calcium-binding repeat (2 copies); Region: HemolysinCabind; pfam00353 862719014253 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719014254 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719014255 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719014256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014257 Walker A/P-loop; other site 862719014258 ATP binding site [chemical binding]; other site 862719014259 Q-loop/lid; other site 862719014260 ABC transporter signature motif; other site 862719014261 Walker B; other site 862719014262 D-loop; other site 862719014263 H-loop/switch region; other site 862719014264 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 862719014265 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719014266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014267 Walker A/P-loop; other site 862719014268 ATP binding site [chemical binding]; other site 862719014269 Q-loop/lid; other site 862719014270 ABC transporter signature motif; other site 862719014271 Walker B; other site 862719014272 D-loop; other site 862719014273 H-loop/switch region; other site 862719014274 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719014275 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719014276 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719014277 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 862719014278 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719014279 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719014280 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719014281 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 862719014282 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719014283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862719014284 DNA polymerase I; Provisional; Region: PRK05755 862719014285 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 862719014286 active site 862719014287 metal binding site 1 [ion binding]; metal-binding site 862719014288 putative 5' ssDNA interaction site; other site 862719014289 metal binding site 3; metal-binding site 862719014290 metal binding site 2 [ion binding]; metal-binding site 862719014291 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 862719014292 putative DNA binding site [nucleotide binding]; other site 862719014293 putative metal binding site [ion binding]; other site 862719014294 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 862719014295 active site 862719014296 catalytic site [active] 862719014297 substrate binding site [chemical binding]; other site 862719014298 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 862719014299 active site 862719014300 DNA binding site [nucleotide binding] 862719014301 catalytic site [active] 862719014302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719014303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014304 active site 862719014305 phosphorylation site [posttranslational modification] 862719014306 intermolecular recognition site; other site 862719014307 dimerization interface [polypeptide binding]; other site 862719014308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719014309 DNA binding site [nucleotide binding] 862719014310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 862719014311 substrate binding pocket [chemical binding]; other site 862719014312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719014313 membrane-bound complex binding site; other site 862719014314 hinge residues; other site 862719014315 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 862719014316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719014317 dimerization interface [polypeptide binding]; other site 862719014318 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719014319 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 862719014320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014321 dimer interface [polypeptide binding]; other site 862719014322 phosphorylation site [posttranslational modification] 862719014323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014324 ATP binding site [chemical binding]; other site 862719014325 Mg2+ binding site [ion binding]; other site 862719014326 G-X-G motif; other site 862719014327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014328 metal binding site [ion binding]; metal-binding site 862719014329 active site 862719014330 I-site; other site 862719014331 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 862719014332 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 862719014333 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 862719014334 agmatine deiminase; Region: agmatine_aguA; TIGR03380 862719014335 Sulfatase; Region: Sulfatase; cl10460 862719014336 Sulfatase; Region: Sulfatase; cl10460 862719014337 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719014338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014339 dimer interface [polypeptide binding]; other site 862719014340 conserved gate region; other site 862719014341 putative PBP binding loops; other site 862719014342 ABC-ATPase subunit interface; other site 862719014343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014344 dimer interface [polypeptide binding]; other site 862719014345 conserved gate region; other site 862719014346 putative PBP binding loops; other site 862719014347 ABC-ATPase subunit interface; other site 862719014348 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 862719014349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014350 Walker A/P-loop; other site 862719014351 ATP binding site [chemical binding]; other site 862719014352 Q-loop/lid; other site 862719014353 ABC transporter signature motif; other site 862719014354 Walker B; other site 862719014355 D-loop; other site 862719014356 H-loop/switch region; other site 862719014357 TOBE domain; Region: TOBE_2; cl01440 862719014358 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 862719014359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014360 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 862719014361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719014362 FeS/SAM binding site; other site 862719014363 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 862719014364 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719014365 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719014366 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719014367 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 862719014368 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 862719014369 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719014370 UbiA prenyltransferase family; Region: UbiA; cl00337 862719014371 UbiA prenyltransferase family; Region: UbiA; cl00337 862719014372 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 862719014373 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 862719014374 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 862719014375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014376 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719014377 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862719014378 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 862719014379 Walker A/P-loop; other site 862719014380 ATP binding site [chemical binding]; other site 862719014381 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862719014382 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 862719014383 ABC transporter signature motif; other site 862719014384 Walker B; other site 862719014385 D-loop; other site 862719014386 H-loop/switch region; other site 862719014387 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719014388 Protein of unknown function (DUF721); Region: DUF721; cl02324 862719014389 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 862719014390 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719014391 minor groove reading motif; other site 862719014392 helix-hairpin-helix signature motif; other site 862719014393 substrate binding pocket [chemical binding]; other site 862719014394 active site 862719014395 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 862719014396 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 862719014397 DNA binding and oxoG recognition site [nucleotide binding] 862719014398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719014399 metal ion-dependent adhesion site (MIDAS); other site 862719014400 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719014401 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 862719014402 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719014403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719014404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014405 active site 862719014406 phosphorylation site [posttranslational modification] 862719014407 intermolecular recognition site; other site 862719014408 dimerization interface [polypeptide binding]; other site 862719014409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719014410 dimerization interface [polypeptide binding]; other site 862719014411 DNA binding residues [nucleotide binding] 862719014412 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 862719014413 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719014414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719014415 active site 862719014416 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719014417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014418 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 862719014419 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719014420 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719014421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719014422 substrate binding site [chemical binding]; other site 862719014423 oxyanion hole (OAH) forming residues; other site 862719014424 trimer interface [polypeptide binding]; other site 862719014425 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719014426 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 862719014427 dimer interface [polypeptide binding]; other site 862719014428 active site 862719014429 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719014430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719014431 DNA binding residues [nucleotide binding] 862719014432 putative dimer interface [polypeptide binding]; other site 862719014433 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 862719014434 MG2 domain; Region: A2M_N; pfam01835 862719014435 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 862719014436 Alpha-2-macroglobulin family; Region: A2M; pfam00207 862719014437 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 862719014438 surface patch; other site 862719014439 thioester region; other site 862719014440 specificity defining residues; other site 862719014441 hypothetical protein; Provisional; Region: PRK08912 862719014442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719014443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014444 homodimer interface [polypeptide binding]; other site 862719014445 catalytic residue [active] 862719014446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014447 dimer interface [polypeptide binding]; other site 862719014448 putative CheW interface [polypeptide binding]; other site 862719014449 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719014450 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719014451 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 862719014452 AsmA-like C-terminal region; Region: AsmA_2; cl15864 862719014453 EamA-like transporter family; Region: EamA; cl01037 862719014454 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719014455 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719014456 Helix-turn-helix domains; Region: HTH; cl00088 862719014457 Helix-turn-helix domains; Region: HTH; cl00088 862719014458 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 862719014459 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 862719014460 putative NAD(P) binding site [chemical binding]; other site 862719014461 catalytic Zn binding site [ion binding]; other site 862719014462 structural Zn binding site [ion binding]; other site 862719014463 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719014464 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719014465 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 862719014466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719014467 inhibitor-cofactor binding pocket; inhibition site 862719014468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014469 catalytic residue [active] 862719014470 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719014471 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 862719014472 tetramerization interface [polypeptide binding]; other site 862719014473 NAD(P) binding site [chemical binding]; other site 862719014474 catalytic residues [active] 862719014475 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 862719014476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719014477 non-specific DNA binding site [nucleotide binding]; other site 862719014478 salt bridge; other site 862719014479 sequence-specific DNA binding site [nucleotide binding]; other site 862719014480 Cupin domain; Region: Cupin_2; cl09118 862719014481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014482 dimer interface [polypeptide binding]; other site 862719014483 conserved gate region; other site 862719014484 putative PBP binding loops; other site 862719014485 ABC-ATPase subunit interface; other site 862719014486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014487 dimer interface [polypeptide binding]; other site 862719014488 conserved gate region; other site 862719014489 putative PBP binding loops; other site 862719014490 ABC-ATPase subunit interface; other site 862719014491 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719014492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014493 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719014494 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 862719014495 Walker A/P-loop; other site 862719014496 ATP binding site [chemical binding]; other site 862719014497 Q-loop/lid; other site 862719014498 ABC transporter signature motif; other site 862719014499 Walker B; other site 862719014500 D-loop; other site 862719014501 H-loop/switch region; other site 862719014502 TOBE domain; Region: TOBE_2; cl01440 862719014503 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719014504 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719014505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 862719014506 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 862719014507 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 862719014508 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 862719014509 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 862719014510 active site 862719014511 catalytic site [active] 862719014512 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 862719014513 Helix-turn-helix domains; Region: HTH; cl00088 862719014514 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862719014515 dimerization interface [polypeptide binding]; other site 862719014516 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 862719014517 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 862719014518 tetramer interface [polypeptide binding]; other site 862719014519 heme binding pocket [chemical binding]; other site 862719014520 NADPH binding site [chemical binding]; other site 862719014521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719014522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719014523 catalytic residue [active] 862719014524 Sporulation related domain; Region: SPOR; cl10051 862719014525 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719014526 GAF domain; Region: GAF_2; pfam13185 862719014527 GAF domain; Region: GAF; cl15785 862719014528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719014529 Helix-turn-helix domains; Region: HTH; cl00088 862719014530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719014531 dimerization interface [polypeptide binding]; other site 862719014532 acetylornithine deacetylase; Validated; Region: PRK06915 862719014533 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 862719014534 metal binding site [ion binding]; metal-binding site 862719014535 dimer interface [polypeptide binding]; other site 862719014536 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 862719014537 intersubunit interface [polypeptide binding]; other site 862719014538 active site 862719014539 Zn2+ binding site [ion binding]; other site 862719014540 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719014541 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 862719014542 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719014543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014544 dimer interface [polypeptide binding]; other site 862719014545 conserved gate region; other site 862719014546 putative PBP binding loops; other site 862719014547 ABC-ATPase subunit interface; other site 862719014548 dipeptide transporter; Provisional; Region: PRK10913 862719014549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014550 dimer interface [polypeptide binding]; other site 862719014551 conserved gate region; other site 862719014552 putative PBP binding loops; other site 862719014553 ABC-ATPase subunit interface; other site 862719014554 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862719014555 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719014556 Walker A/P-loop; other site 862719014557 ATP binding site [chemical binding]; other site 862719014558 Q-loop/lid; other site 862719014559 ABC transporter signature motif; other site 862719014560 Walker B; other site 862719014561 D-loop; other site 862719014562 H-loop/switch region; other site 862719014563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719014564 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862719014565 Walker A/P-loop; other site 862719014566 ATP binding site [chemical binding]; other site 862719014567 Q-loop/lid; other site 862719014568 ABC transporter signature motif; other site 862719014569 Walker B; other site 862719014570 D-loop; other site 862719014571 H-loop/switch region; other site 862719014572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719014573 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 862719014574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014575 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 862719014576 allantoate amidohydrolase; Reviewed; Region: PRK12893 862719014577 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 862719014578 active site 862719014579 metal binding site [ion binding]; metal-binding site 862719014580 dimer interface [polypeptide binding]; other site 862719014581 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719014582 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 862719014583 EamA-like transporter family; Region: EamA; cl01037 862719014584 EamA-like transporter family; Region: EamA; cl01037 862719014585 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719014586 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719014587 catalytic residues [active] 862719014588 catalytic nucleophile [active] 862719014589 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719014590 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719014591 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719014592 Synaptic Site I dimer interface [polypeptide binding]; other site 862719014593 DNA binding site [nucleotide binding] 862719014594 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 862719014595 Transposase domain (DUF772); Region: DUF772; cl15789 862719014596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719014597 Transposase domain (DUF772); Region: DUF772; cl15789 862719014598 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719014599 Transposase domain (DUF772); Region: DUF772; cl15789 862719014600 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862719014601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719014602 salt bridge; other site 862719014603 non-specific DNA binding site [nucleotide binding]; other site 862719014604 sequence-specific DNA binding site [nucleotide binding]; other site 862719014605 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 862719014606 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719014607 dimer interface [polypeptide binding]; other site 862719014608 PYR/PP interface [polypeptide binding]; other site 862719014609 TPP binding site [chemical binding]; other site 862719014610 substrate binding site [chemical binding]; other site 862719014611 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862719014612 TPP-binding site [chemical binding]; other site 862719014613 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 862719014614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014615 binding surface 862719014616 TPR motif; other site 862719014617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014618 binding surface 862719014619 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 862719014620 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 862719014621 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 862719014622 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719014623 DXD motif; other site 862719014624 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 862719014625 PilZ domain; Region: PilZ; cl01260 862719014626 Membrane transport protein; Region: Mem_trans; cl09117 862719014627 OsmC-like protein; Region: OsmC; cl00767 862719014628 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 862719014629 putative FMN binding site [chemical binding]; other site 862719014630 NAD synthetase; Reviewed; Region: nadE; PRK02628 862719014631 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 862719014632 multimer interface [polypeptide binding]; other site 862719014633 active site 862719014634 catalytic triad [active] 862719014635 protein interface 1 [polypeptide binding]; other site 862719014636 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 862719014637 homodimer interface [polypeptide binding]; other site 862719014638 NAD binding pocket [chemical binding]; other site 862719014639 ATP binding pocket [chemical binding]; other site 862719014640 Mg binding site [ion binding]; other site 862719014641 active-site loop [active] 862719014642 Flagellar protein FlaF; Region: FlaF; cl11454 862719014643 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719014644 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862719014645 putative active site [active] 862719014646 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 862719014647 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862719014648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014649 TPR motif; other site 862719014650 TPR repeat; Region: TPR_11; pfam13414 862719014651 binding surface 862719014652 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719014653 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719014654 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 862719014655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719014656 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 862719014657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719014658 catalytic residue [active] 862719014659 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719014660 LamB/YcsF family; Region: LamB_YcsF; cl00664 862719014661 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719014662 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 862719014663 P-loop; other site 862719014664 Magnesium ion binding site [ion binding]; other site 862719014665 Helix-turn-helix domains; Region: HTH; cl00088 862719014666 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719014667 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 862719014668 active sites [active] 862719014669 tetramer interface [polypeptide binding]; other site 862719014670 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 862719014671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719014672 active site 862719014673 imidazolonepropionase; Validated; Region: PRK09356 862719014674 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 862719014675 active site 862719014676 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 862719014677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719014678 DNA-binding site [nucleotide binding]; DNA binding site 862719014679 UTRA domain; Region: UTRA; cl01230 862719014680 urocanate hydratase; Provisional; Region: PRK05414 862719014681 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 862719014682 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 862719014683 homodimer interface [polypeptide binding]; other site 862719014684 substrate-cofactor binding pocket; other site 862719014685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014686 catalytic residue [active] 862719014687 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 862719014688 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719014689 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719014690 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 862719014691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014692 NAD(P) binding site [chemical binding]; other site 862719014693 active site 862719014694 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 862719014695 Clp amino terminal domain; Region: Clp_N; pfam02861 862719014696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719014697 Walker A motif; other site 862719014698 ATP binding site [chemical binding]; other site 862719014699 Walker B motif; other site 862719014700 arginine finger; other site 862719014701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719014702 Walker A motif; other site 862719014703 ATP binding site [chemical binding]; other site 862719014704 Walker B motif; other site 862719014705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862719014706 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 862719014707 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 862719014708 Helix-turn-helix domains; Region: HTH; cl00088 862719014709 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 862719014710 putative dimerization interface [polypeptide binding]; other site 862719014711 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719014712 ligand binding site [chemical binding]; other site 862719014713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719014714 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719014715 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 862719014716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719014717 ligand binding site [chemical binding]; other site 862719014718 flexible hinge region; other site 862719014719 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 862719014720 EamA-like transporter family; Region: EamA; cl01037 862719014721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719014722 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 862719014723 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719014724 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719014725 Helix-turn-helix domains; Region: HTH; cl00088 862719014726 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719014727 putative effector binding pocket; other site 862719014728 dimerization interface [polypeptide binding]; other site 862719014729 choline dehydrogenase; Validated; Region: PRK02106 862719014730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014731 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719014732 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719014733 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719014734 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 862719014735 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719014736 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 862719014737 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 862719014738 structural tetrad; other site 862719014739 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 862719014740 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 862719014741 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719014742 ligand binding site [chemical binding]; other site 862719014743 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 862719014744 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 862719014745 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719014746 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 862719014747 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 862719014748 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 862719014749 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 862719014750 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 862719014751 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 862719014752 PAAR motif; Region: PAAR_motif; cl15808 862719014753 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719014754 phosphopeptide binding site; other site 862719014755 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 862719014756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719014757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719014758 active site 862719014759 ATP binding site [chemical binding]; other site 862719014760 substrate binding site [chemical binding]; other site 862719014761 activation loop (A-loop); other site 862719014762 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719014763 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 862719014764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719014765 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719014766 Helix-turn-helix domains; Region: HTH; cl00088 862719014767 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719014768 putative effector binding pocket; other site 862719014769 dimerization interface [polypeptide binding]; other site 862719014770 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 862719014771 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 862719014772 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719014773 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 862719014774 putative dimer interface [polypeptide binding]; other site 862719014775 N-terminal domain interface [polypeptide binding]; other site 862719014776 putative substrate binding pocket (H-site) [chemical binding]; other site 862719014777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719014778 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 862719014779 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719014780 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 862719014781 CcdB protein; Region: CcdB; cl03380 862719014782 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 862719014783 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 862719014784 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 862719014785 active site 862719014786 substrate binding site [chemical binding]; other site 862719014787 coenzyme B12 binding site [chemical binding]; other site 862719014788 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 862719014789 B12 binding site [chemical binding]; other site 862719014790 cobalt ligand [ion binding]; other site 862719014791 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 862719014792 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719014793 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862719014794 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 862719014795 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719014796 carboxyltransferase (CT) interaction site; other site 862719014797 biotinylation site [posttranslational modification]; other site 862719014798 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 862719014799 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719014800 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 862719014801 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719014802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719014803 non-specific DNA binding site [nucleotide binding]; other site 862719014804 salt bridge; other site 862719014805 sequence-specific DNA binding site [nucleotide binding]; other site 862719014806 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 862719014807 Domain of unknown function (DUF955); Region: DUF955; cl01076 862719014808 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 862719014809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719014810 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719014811 substrate binding pocket [chemical binding]; other site 862719014812 membrane-bound complex binding site; other site 862719014813 hinge residues; other site 862719014814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014815 metal binding site [ion binding]; metal-binding site 862719014816 active site 862719014817 I-site; other site 862719014818 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014820 active site 862719014821 phosphorylation site [posttranslational modification] 862719014822 intermolecular recognition site; other site 862719014823 dimerization interface [polypeptide binding]; other site 862719014824 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 862719014825 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 862719014826 cytochrome b; Provisional; Region: CYTB; MTH00191 862719014827 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 862719014828 Qi binding site; other site 862719014829 intrachain domain interface; other site 862719014830 interchain domain interface [polypeptide binding]; other site 862719014831 heme bH binding site [chemical binding]; other site 862719014832 heme bL binding site [chemical binding]; other site 862719014833 Qo binding site; other site 862719014834 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 862719014835 interchain domain interface [polypeptide binding]; other site 862719014836 intrachain domain interface; other site 862719014837 Qi binding site; other site 862719014838 Qo binding site; other site 862719014839 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 862719014840 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 862719014841 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 862719014842 [2Fe-2S] cluster binding site [ion binding]; other site 862719014843 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862719014844 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 862719014845 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 862719014846 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 862719014847 active site 862719014848 DNA binding site [nucleotide binding] 862719014849 Int/Topo IB signature motif; other site 862719014850 catalytic residues [active] 862719014851 MarC family integral membrane protein; Region: MarC; cl00919 862719014852 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 862719014853 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 862719014854 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 862719014855 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 862719014856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719014857 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719014858 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 862719014859 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 862719014860 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719014861 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719014862 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 862719014863 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 862719014864 XdhC Rossmann domain; Region: XdhC_C; pfam13478 862719014865 ATP synthase; Region: ATP-synt; cl00365 862719014866 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 862719014867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862719014868 Walker A motif; other site 862719014869 ATP binding site [chemical binding]; other site 862719014870 Walker B motif; other site 862719014871 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719014872 Plant ATP synthase F0; Region: YMF19; cl07975 862719014873 ATP synthase subunit C; Region: ATP-synt_C; cl00466 862719014874 ATP synthase A chain; Region: ATP-synt_A; cl00413 862719014875 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 862719014876 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 862719014877 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 862719014878 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 862719014879 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 862719014880 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862719014881 alpha subunit interaction interface [polypeptide binding]; other site 862719014882 Walker A motif; other site 862719014883 ATP binding site [chemical binding]; other site 862719014884 Walker B motif; other site 862719014885 inhibitor binding site; inhibition site 862719014886 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719014887 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719014888 ligand binding site [chemical binding]; other site 862719014889 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719014890 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 862719014891 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719014892 tetrameric interface [polypeptide binding]; other site 862719014893 NAD binding site [chemical binding]; other site 862719014894 catalytic residues [active] 862719014895 thiamine pyrophosphate protein; Validated; Region: PRK08199 862719014896 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719014897 PYR/PP interface [polypeptide binding]; other site 862719014898 dimer interface [polypeptide binding]; other site 862719014899 TPP binding site [chemical binding]; other site 862719014900 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 862719014901 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 862719014902 TPP-binding site [chemical binding]; other site 862719014903 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719014904 Helix-turn-helix domains; Region: HTH; cl00088 862719014905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014906 dimerization interface [polypeptide binding]; other site 862719014907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719014908 active site 862719014909 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 862719014910 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719014911 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 862719014912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719014913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719014914 DNA binding residues [nucleotide binding] 862719014915 dimerization interface [polypeptide binding]; other site 862719014916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719014917 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719014918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719014919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719014920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719014921 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719014922 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862719014923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719014924 active site 862719014925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719014926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719014927 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 862719014928 putative ADP-binding pocket [chemical binding]; other site 862719014929 Chain length determinant protein; Region: Wzz; cl15801 862719014930 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 862719014931 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 862719014932 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719014933 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719014934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014935 S-adenosylmethionine binding site [chemical binding]; other site 862719014936 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 862719014937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719014938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719014939 DNA binding site [nucleotide binding] 862719014940 domain linker motif; other site 862719014941 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 862719014942 putative dimerization interface [polypeptide binding]; other site 862719014943 putative ligand binding site [chemical binding]; other site 862719014944 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719014945 active site 862719014946 phosphorylation site [posttranslational modification] 862719014947 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719014948 dimerization domain swap beta strand [polypeptide binding]; other site 862719014949 regulatory protein interface [polypeptide binding]; other site 862719014950 active site 862719014951 regulatory phosphorylation site [posttranslational modification]; other site 862719014952 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719014953 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719014954 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862719014955 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862719014956 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 862719014957 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 862719014958 putative substrate binding site [chemical binding]; other site 862719014959 putative ATP binding site [chemical binding]; other site 862719014960 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862719014961 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 862719014962 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862719014963 active site 862719014964 P-loop; other site 862719014965 phosphorylation site [posttranslational modification] 862719014966 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862719014967 acetoin reductase; Validated; Region: PRK08643 862719014968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014969 binding surface 862719014970 TPR motif; other site 862719014971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014972 TPR repeat; Region: TPR_11; pfam13414 862719014973 binding surface 862719014974 TPR motif; other site 862719014975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014976 TPR motif; other site 862719014977 binding surface 862719014978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719014979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719014980 binding surface 862719014981 TPR motif; other site 862719014982 TPR repeat; Region: TPR_11; pfam13414 862719014983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719014984 binding surface 862719014985 TPR motif; other site 862719014986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862719014987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719014988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719014989 DNA binding residues [nucleotide binding] 862719014990 Flagellar protein FliS; Region: FliS; cl00654 862719014991 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 862719014992 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 862719014993 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 862719014994 flagellin; Provisional; Region: PRK12802 862719014995 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719014996 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719014997 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 862719014998 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719014999 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719015000 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 862719015001 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 862719015002 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015003 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719015004 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719015005 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015006 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719015007 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719015008 FlgD Ig-like domain; Region: FlgD_ig; cl15790 862719015009 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719015010 substrate binding site [chemical binding]; other site 862719015011 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 862719015012 oxyanion hole (OAH) forming residues; other site 862719015013 trimer interface [polypeptide binding]; other site 862719015014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015015 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719015016 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719015017 Cytochrome c; Region: Cytochrom_C; cl11414 862719015018 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719015019 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719015020 alpha subunit interface [polypeptide binding]; other site 862719015021 TPP binding site [chemical binding]; other site 862719015022 heterodimer interface [polypeptide binding]; other site 862719015023 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719015024 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719015025 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719015026 tetramer interface [polypeptide binding]; other site 862719015027 TPP-binding site [chemical binding]; other site 862719015028 heterodimer interface [polypeptide binding]; other site 862719015029 phosphorylation loop region [posttranslational modification] 862719015030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015031 putative PBP binding loops; other site 862719015032 ABC-ATPase subunit interface; other site 862719015033 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 862719015034 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 862719015035 Walker A/P-loop; other site 862719015036 ATP binding site [chemical binding]; other site 862719015037 Q-loop/lid; other site 862719015038 ABC transporter signature motif; other site 862719015039 Walker B; other site 862719015040 D-loop; other site 862719015041 H-loop/switch region; other site 862719015042 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719015043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015044 dimer interface [polypeptide binding]; other site 862719015045 conserved gate region; other site 862719015046 ABC-ATPase subunit interface; other site 862719015047 NMT1-like family; Region: NMT1_2; cl15260 862719015048 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 862719015049 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719015050 catalytic triad [active] 862719015051 conserved cis-peptide bond; other site 862719015052 Helix-turn-helix domains; Region: HTH; cl00088 862719015053 Helix-turn-helix domains; Region: HTH; cl00088 862719015054 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 862719015055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719015056 FeS/SAM binding site; other site 862719015057 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 862719015058 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 862719015059 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 862719015060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719015061 PqqA family; Region: PqqA; cl15372 862719015062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719015063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719015064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015065 active site 862719015066 phosphorylation site [posttranslational modification] 862719015067 intermolecular recognition site; other site 862719015068 dimerization interface [polypeptide binding]; other site 862719015069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719015070 DNA binding residues [nucleotide binding] 862719015071 dimerization interface [polypeptide binding]; other site 862719015072 Cytochrome c; Region: Cytochrom_C; cl11414 862719015073 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 862719015074 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719015075 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719015076 putative active site [active] 862719015077 Dehydratase family; Region: ILVD_EDD; cl00340 862719015078 6-phosphogluconate dehydratase; Region: edd; TIGR01196 862719015079 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 862719015080 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 862719015081 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 862719015082 potential protein location (conserved protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 23S ribosomal RNA) 862719015083 potential protein location (protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 23S ribosomal RNA) 862719015084 potential protein location (protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 5S ribosomal RNA) 862719015085 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 862719015086 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862719015087 putative active site [active] 862719015088 catalytic site [active] 862719015089 putative metal binding site [ion binding]; other site 862719015090 Rod binding protein; Region: Rod-binding; cl01626 862719015091 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 862719015092 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 862719015093 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 862719015094 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719015095 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719015096 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 862719015097 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015098 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719015099 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719015100 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719015101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015102 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015103 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719015104 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719015105 ligand binding site [chemical binding]; other site 862719015106 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 862719015107 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719015108 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 862719015109 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015110 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 862719015111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015112 SAF domain; Region: SAF; cl00555 862719015113 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 862719015114 Flagellar L-ring protein; Region: FlgH; cl00905 862719015115 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719015116 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719015117 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719015118 FlgD Ig-like domain; Region: FlgD_ig; cl15790 862719015119 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 862719015120 MgtE intracellular N domain; Region: MgtE_N; cl15244 862719015121 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 862719015122 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719015123 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719015124 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 862719015125 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 862719015126 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 862719015127 flagellar assembly protein H; Validated; Region: fliH; PRK06032 862719015128 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719015129 FliP family; Region: FliP; cl00593 862719015130 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719015131 MgtE intracellular N domain; Region: MgtE_N; cl15244 862719015132 FliG C-terminal domain; Region: FliG_C; pfam01706 862719015133 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719015134 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 862719015135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719015136 DNA binding site [nucleotide binding] 862719015137 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 862719015138 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719015139 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719015140 Flagellar protein FlaF; Region: FlaF; cl11454 862719015141 Flagellar protein FlbT; Region: FlbT; cl11455 862719015142 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 862719015143 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 862719015144 Protein of unknown function (DUF454); Region: DUF454; cl01063 862719015145 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 862719015146 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 862719015147 Walker A motif/ATP binding site; other site 862719015148 Walker B motif; other site 862719015149 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 862719015150 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719015151 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 862719015152 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 862719015153 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719015154 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 862719015155 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 862719015156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719015157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719015158 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719015159 Transposase domain (DUF772); Region: DUF772; cl15789 862719015160 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 862719015161 FHIPEP family; Region: FHIPEP; pfam00771 862719015162 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 862719015163 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 862719015164 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 862719015165 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 862719015166 dihydropteroate synthase; Region: DHPS; TIGR01496 862719015167 substrate binding pocket [chemical binding]; other site 862719015168 dimer interface [polypeptide binding]; other site 862719015169 inhibitor binding site; inhibition site 862719015170 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 862719015171 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 862719015172 active site 862719015173 substrate binding site [chemical binding]; other site 862719015174 metal binding site [ion binding]; metal-binding site 862719015175 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 862719015176 dimer interface [polypeptide binding]; other site 862719015177 substrate binding site [chemical binding]; other site 862719015178 ATP binding site [chemical binding]; other site 862719015179 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 862719015180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719015182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719015183 Helix-turn-helix domains; Region: HTH; cl00088 862719015184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719015185 dimerization interface [polypeptide binding]; other site 862719015186 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719015187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719015188 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719015189 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 862719015190 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719015191 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719015192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719015193 catalytic core [active] 862719015194 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 862719015195 active site 862719015196 SUMO-1 interface [polypeptide binding]; other site 862719015197 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719015198 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719015199 Domain of unknown function (DUF305); Region: DUF305; cl15795 862719015200 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 862719015201 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 862719015202 Cation transport protein; Region: TrkH; cl10514 862719015203 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 862719015204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015205 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719015206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015207 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862719015208 putative glutathione S-transferase; Provisional; Region: PRK10357 862719015209 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 862719015210 putative C-terminal domain interface [polypeptide binding]; other site 862719015211 putative GSH binding site (G-site) [chemical binding]; other site 862719015212 putative dimer interface [polypeptide binding]; other site 862719015213 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 862719015214 dimer interface [polypeptide binding]; other site 862719015215 N-terminal domain interface [polypeptide binding]; other site 862719015216 putative substrate binding pocket (H-site) [chemical binding]; other site 862719015217 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719015219 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015221 putative CheW interface [polypeptide binding]; other site 862719015222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719015223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015224 dimer interface [polypeptide binding]; other site 862719015225 conserved gate region; other site 862719015226 putative PBP binding loops; other site 862719015227 ABC-ATPase subunit interface; other site 862719015228 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 862719015229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015230 dimer interface [polypeptide binding]; other site 862719015231 conserved gate region; other site 862719015232 putative PBP binding loops; other site 862719015233 ABC-ATPase subunit interface; other site 862719015234 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 862719015235 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 862719015236 Walker A/P-loop; other site 862719015237 ATP binding site [chemical binding]; other site 862719015238 Q-loop/lid; other site 862719015239 ABC transporter signature motif; other site 862719015240 Walker B; other site 862719015241 D-loop; other site 862719015242 H-loop/switch region; other site 862719015243 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719015244 Helix-turn-helix domains; Region: HTH; cl00088 862719015245 Helix-turn-helix domains; Region: HTH; cl00088 862719015246 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 862719015247 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 862719015248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719015249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719015250 putative substrate translocation pore; other site 862719015251 hypothetical protein; Provisional; Region: PRK01254 862719015252 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862719015253 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 862719015254 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015256 active site 862719015257 phosphorylation site [posttranslational modification] 862719015258 intermolecular recognition site; other site 862719015259 dimerization interface [polypeptide binding]; other site 862719015260 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719015261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015262 PAS domain; Region: PAS_9; pfam13426 862719015263 putative active site [active] 862719015264 heme pocket [chemical binding]; other site 862719015265 PAS fold; Region: PAS_4; pfam08448 862719015266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719015267 Histidine kinase; Region: HisKA_2; cl06527 862719015268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015269 ATP binding site [chemical binding]; other site 862719015270 Mg2+ binding site [ion binding]; other site 862719015271 G-X-G motif; other site 862719015272 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 862719015273 Chemotaxis phosphatase CheX; Region: CheX; cl15816 862719015274 Chemotaxis phosphatase CheX; Region: CheX; cl15816 862719015275 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 862719015276 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 862719015277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015278 active site 862719015279 phosphorylation site [posttranslational modification] 862719015280 intermolecular recognition site; other site 862719015281 dimerization interface [polypeptide binding]; other site 862719015282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719015283 Zn2+ binding site [ion binding]; other site 862719015284 Mg2+ binding site [ion binding]; other site 862719015285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015286 PAS domain; Region: PAS_9; pfam13426 862719015287 putative active site [active] 862719015288 heme pocket [chemical binding]; other site 862719015289 PAS domain S-box; Region: sensory_box; TIGR00229 862719015290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015291 putative active site [active] 862719015292 heme pocket [chemical binding]; other site 862719015293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015294 PAS fold; Region: PAS_3; pfam08447 862719015295 putative active site [active] 862719015296 heme pocket [chemical binding]; other site 862719015297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015298 dimer interface [polypeptide binding]; other site 862719015299 phosphorylation site [posttranslational modification] 862719015300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015301 ATP binding site [chemical binding]; other site 862719015302 Mg2+ binding site [ion binding]; other site 862719015303 G-X-G motif; other site 862719015304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015305 active site 862719015306 phosphorylation site [posttranslational modification] 862719015307 intermolecular recognition site; other site 862719015308 dimerization interface [polypeptide binding]; other site 862719015309 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015311 active site 862719015312 phosphorylation site [posttranslational modification] 862719015313 intermolecular recognition site; other site 862719015314 dimerization interface [polypeptide binding]; other site 862719015315 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719015316 Uncharacterized conserved protein [Function unknown]; Region: COG3287 862719015317 FIST N domain; Region: FIST; cl10701 862719015318 FIST C domain; Region: FIST_C; pfam10442 862719015319 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015320 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719015322 dimerization interface [polypeptide binding]; other site 862719015323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015324 dimer interface [polypeptide binding]; other site 862719015325 putative CheW interface [polypeptide binding]; other site 862719015326 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 862719015327 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 862719015328 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719015329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719015330 DNA-binding site [nucleotide binding]; DNA binding site 862719015331 FCD domain; Region: FCD; cl11656 862719015332 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 862719015333 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719015334 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719015335 putative oxidoreductase; Provisional; Region: PRK10083 862719015336 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 862719015337 putative NAD(P) binding site [chemical binding]; other site 862719015338 catalytic Zn binding site [ion binding]; other site 862719015339 structural Zn binding site [ion binding]; other site 862719015340 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719015341 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719015342 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719015343 DctM-like transporters; Region: DctM; pfam06808 862719015344 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719015345 mannonate dehydratase; Provisional; Region: PRK03906 862719015346 mannonate dehydratase; Region: uxuA; TIGR00695 862719015347 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 862719015348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719015349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015350 Walker A motif; other site 862719015351 ATP binding site [chemical binding]; other site 862719015352 Walker B motif; other site 862719015353 arginine finger; other site 862719015354 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719015355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015356 dimer interface [polypeptide binding]; other site 862719015357 phosphorylation site [posttranslational modification] 862719015358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015359 ATP binding site [chemical binding]; other site 862719015360 Mg2+ binding site [ion binding]; other site 862719015361 G-X-G motif; other site 862719015362 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 862719015363 DctM-like transporters; Region: DctM; pfam06808 862719015364 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862719015365 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17449609, 17540897; Product type e : enzyme 862719015366 Transposase domain (DUF772); Region: DUF772; cl15789 862719015367 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719015368 multiple promoter invertase; Provisional; Region: mpi; PRK13413 862719015369 catalytic residues [active] 862719015370 catalytic nucleophile [active] 862719015371 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719015372 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719015373 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719015374 Synaptic Site I dimer interface [polypeptide binding]; other site 862719015375 DNA binding site [nucleotide binding] 862719015376 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 862719015377 DNA-binding interface [nucleotide binding]; DNA binding site 862719015378 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 862719015379 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 862719015380 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 862719015381 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 862719015382 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719015383 Winged helix-turn helix; Region: HTH_29; pfam13551 862719015384 Helix-turn-helix domains; Region: HTH; cl00088 862719015385 Winged helix-turn helix; Region: HTH_33; pfam13592 862719015386 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16640791; Product type pe : putative enzyme 862719015387 Evidence 2b : Function of strongly homologous gene; PubMedId : 15917576, 16785225, 9420034; Product type e : enzyme 862719015388 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719015389 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719015390 Walker A/P-loop; other site 862719015391 ATP binding site [chemical binding]; other site 862719015392 Q-loop/lid; other site 862719015393 ABC transporter signature motif; other site 862719015394 Walker B; other site 862719015395 D-loop; other site 862719015396 H-loop/switch region; other site 862719015397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719015398 ABC-ATPase subunit interface; other site 862719015399 dimer interface [polypeptide binding]; other site 862719015400 putative PBP binding regions; other site 862719015401 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 862719015402 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 862719015403 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 862719015404 FAD binding pocket [chemical binding]; other site 862719015405 FAD binding motif [chemical binding]; other site 862719015406 phosphate binding motif [ion binding]; other site 862719015407 NAD binding pocket [chemical binding]; other site 862719015408 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 862719015409 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719015410 intersubunit interface [polypeptide binding]; other site 862719015411 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719015412 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719015413 N-terminal plug; other site 862719015414 ligand-binding site [chemical binding]; other site 862719015415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719015416 Helix-turn-helix domains; Region: HTH; cl00088 862719015417 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 862719015418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719015419 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2159625, 2824781; Product type e : enzyme 862719015420 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 862719015421 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 862719015422 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 862719015423 GAF domain; Region: GAF; cl15785 862719015424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015425 Walker B motif; other site 862719015426 arginine finger; other site 862719015427 Helix-turn-helix domains; Region: HTH; cl00088 862719015428 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 862719015429 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 862719015430 heme-binding site [chemical binding]; other site 862719015431 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 862719015432 FAD binding pocket [chemical binding]; other site 862719015433 FAD binding motif [chemical binding]; other site 862719015434 phosphate binding motif [ion binding]; other site 862719015435 beta-alpha-beta structure motif; other site 862719015436 NAD binding pocket [chemical binding]; other site 862719015437 Heme binding pocket [chemical binding]; other site 862719015438 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719015440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015442 dimer interface [polypeptide binding]; other site 862719015443 putative CheW interface [polypeptide binding]; other site 862719015444 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862719015445 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719015446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719015447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719015448 putative active site [active] 862719015449 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 862719015450 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 862719015451 active site 862719015452 intersubunit interface [polypeptide binding]; other site 862719015453 catalytic residue [active] 862719015454 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 862719015455 Tripeptidyl peptidase II; Region: TPPII; pfam12580 862719015456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719015457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015458 active site 862719015459 phosphorylation site [posttranslational modification] 862719015460 intermolecular recognition site; other site 862719015461 dimerization interface [polypeptide binding]; other site 862719015462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719015463 DNA binding residues [nucleotide binding] 862719015464 dimerization interface [polypeptide binding]; other site 862719015465 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 862719015466 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719015467 ligand binding site [chemical binding]; other site 862719015468 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719015469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719015470 TIGR03032 family protein; Region: TIGR03032 862719015471 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 862719015472 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 862719015473 dimerization interface [polypeptide binding]; other site 862719015474 ligand binding site [chemical binding]; other site 862719015475 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719015476 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 862719015477 Walker A/P-loop; other site 862719015478 ATP binding site [chemical binding]; other site 862719015479 Q-loop/lid; other site 862719015480 ABC transporter signature motif; other site 862719015481 Walker B; other site 862719015482 D-loop; other site 862719015483 H-loop/switch region; other site 862719015484 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 862719015485 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 862719015486 Walker A/P-loop; other site 862719015487 ATP binding site [chemical binding]; other site 862719015488 Q-loop/lid; other site 862719015489 ABC transporter signature motif; other site 862719015490 Walker B; other site 862719015491 D-loop; other site 862719015492 H-loop/switch region; other site 862719015493 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719015494 TM-ABC transporter signature motif; other site 862719015495 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719015496 TM-ABC transporter signature motif; other site 862719015497 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862719015498 fructokinase; Reviewed; Region: PRK09557 862719015499 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 862719015500 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 862719015501 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 862719015502 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719015503 Ligand binding site; other site 862719015504 Putative Catalytic site; other site 862719015505 DXD motif; other site 862719015506 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 862719015507 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719015508 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719015509 protein binding site [polypeptide binding]; other site 862719015510 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719015511 protein binding site [polypeptide binding]; other site 862719015512 PAS fold; Region: PAS_7; pfam12860 862719015513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015514 PAS fold; Region: PAS_3; pfam08447 862719015515 putative active site [active] 862719015516 heme pocket [chemical binding]; other site 862719015517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015518 dimer interface [polypeptide binding]; other site 862719015519 phosphorylation site [posttranslational modification] 862719015520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015521 ATP binding site [chemical binding]; other site 862719015522 Mg2+ binding site [ion binding]; other site 862719015523 G-X-G motif; other site 862719015524 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719015525 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719015526 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719015527 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719015528 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719015529 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 862719015530 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 862719015531 active site 862719015532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719015533 S-adenosylmethionine binding site [chemical binding]; other site 862719015534 Cache domain; Region: Cache_2; cl07034 862719015535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719015536 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015538 dimer interface [polypeptide binding]; other site 862719015539 putative CheW interface [polypeptide binding]; other site 862719015540 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 862719015541 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719015542 DNA binding residues [nucleotide binding] 862719015543 putative dimer interface [polypeptide binding]; other site 862719015544 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 862719015545 AMP-binding enzyme; Region: AMP-binding; cl15778 862719015546 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719015547 glycerol kinase; Provisional; Region: glpK; PRK00047 862719015548 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 862719015549 N- and C-terminal domain interface [polypeptide binding]; other site 862719015550 active site 862719015551 MgATP binding site [chemical binding]; other site 862719015552 catalytic site [active] 862719015553 metal binding site [ion binding]; metal-binding site 862719015554 glycerol binding site [chemical binding]; other site 862719015555 homotetramer interface [polypeptide binding]; other site 862719015556 homodimer interface [polypeptide binding]; other site 862719015557 FBP binding site [chemical binding]; other site 862719015558 protein IIAGlc interface [polypeptide binding]; other site 862719015559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 862719015560 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 862719015561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 862719015562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015563 dimer interface [polypeptide binding]; other site 862719015564 conserved gate region; other site 862719015565 putative PBP binding loops; other site 862719015566 ABC-ATPase subunit interface; other site 862719015567 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 862719015568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015569 putative PBP binding loops; other site 862719015570 dimer interface [polypeptide binding]; other site 862719015571 ABC-ATPase subunit interface; other site 862719015572 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 862719015573 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 862719015574 Walker A/P-loop; other site 862719015575 ATP binding site [chemical binding]; other site 862719015576 Q-loop/lid; other site 862719015577 ABC transporter signature motif; other site 862719015578 Walker B; other site 862719015579 D-loop; other site 862719015580 H-loop/switch region; other site 862719015581 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 862719015582 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 862719015583 Walker A/P-loop; other site 862719015584 ATP binding site [chemical binding]; other site 862719015585 Q-loop/lid; other site 862719015586 ABC transporter signature motif; other site 862719015587 Walker B; other site 862719015588 D-loop; other site 862719015589 H-loop/switch region; other site 862719015590 TOBE domain; Region: TOBE_2; cl01440 862719015591 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 862719015592 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719015594 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015596 dimer interface [polypeptide binding]; other site 862719015597 putative CheW interface [polypeptide binding]; other site 862719015598 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 862719015599 Helix-turn-helix domains; Region: HTH; cl00088 862719015600 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 862719015601 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 862719015602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 862719015603 active site 862719015604 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862719015605 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862719015606 GIY-YIG motif/motif A; other site 862719015607 active site 862719015608 catalytic site [active] 862719015609 putative DNA binding site [nucleotide binding]; other site 862719015610 metal binding site [ion binding]; metal-binding site 862719015611 UvrB/uvrC motif; Region: UVR; pfam02151 862719015612 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862719015613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719015614 dimerization interface [polypeptide binding]; other site 862719015615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015616 dimer interface [polypeptide binding]; other site 862719015617 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719015618 putative CheW interface [polypeptide binding]; other site 862719015619 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 862719015620 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719015621 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719015622 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719015623 Ligand Binding Site [chemical binding]; other site 862719015624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 862719015625 Predicted kinase [General function prediction only]; Region: COG0645 862719015626 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 862719015627 Flagellar protein FlaF; Region: FlaF; cl11454 862719015628 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719015629 EamA-like transporter family; Region: EamA; cl01037 862719015630 EamA-like transporter family; Region: EamA; cl01037 862719015631 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 862719015632 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 862719015633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719015634 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719015635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015636 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 862719015637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015638 dimer interface [polypeptide binding]; other site 862719015639 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719015640 putative CheW interface [polypeptide binding]; other site 862719015641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862719015642 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 862719015643 DsrE/DsrF-like family; Region: DrsE; cl00672 862719015644 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719015645 NMT1-like family; Region: NMT1_2; cl15260 862719015646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719015647 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 862719015648 putative substrate translocation pore; other site 862719015649 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719015650 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 862719015651 ligand binding site [chemical binding]; other site 862719015652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719015653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719015654 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719015655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719015656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719015657 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 862719015658 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 862719015659 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 862719015660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015661 active site 862719015662 phosphorylation site [posttranslational modification] 862719015663 intermolecular recognition site; other site 862719015664 dimerization interface [polypeptide binding]; other site 862719015665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719015666 DNA binding site [nucleotide binding] 862719015667 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719015668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719015669 DNA-binding site [nucleotide binding]; DNA binding site 862719015670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719015671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719015672 homodimer interface [polypeptide binding]; other site 862719015673 catalytic residue [active] 862719015674 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 862719015675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719015676 PAS domain; Region: PAS_9; pfam13426 862719015677 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719015678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719015679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015680 ATP binding site [chemical binding]; other site 862719015681 Mg2+ binding site [ion binding]; other site 862719015682 G-X-G motif; other site 862719015683 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015685 active site 862719015686 phosphorylation site [posttranslational modification] 862719015687 intermolecular recognition site; other site 862719015688 dimerization interface [polypeptide binding]; other site 862719015689 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719015690 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862719015691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719015692 substrate binding pocket [chemical binding]; other site 862719015693 membrane-bound complex binding site; other site 862719015694 hinge residues; other site 862719015695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719015696 putative substrate translocation pore; other site 862719015697 metabolite-proton symporter; Region: 2A0106; TIGR00883 862719015698 Sodium:solute symporter family; Region: SSF; cl00456 862719015699 PAS fold; Region: PAS_7; pfam12860 862719015700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015701 dimer interface [polypeptide binding]; other site 862719015702 phosphorylation site [posttranslational modification] 862719015703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015704 ATP binding site [chemical binding]; other site 862719015705 Mg2+ binding site [ion binding]; other site 862719015706 G-X-G motif; other site 862719015707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 862719015708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719015709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015710 active site 862719015711 phosphorylation site [posttranslational modification] 862719015712 intermolecular recognition site; other site 862719015713 dimerization interface [polypeptide binding]; other site 862719015714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719015715 DNA binding residues [nucleotide binding] 862719015716 dimerization interface [polypeptide binding]; other site 862719015717 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 862719015718 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 862719015719 dimer interface [polypeptide binding]; other site 862719015720 Citrate synthase; Region: Citrate_synt; pfam00285 862719015721 active site 862719015722 citrylCoA binding site [chemical binding]; other site 862719015723 NADH binding [chemical binding]; other site 862719015724 cationic pore residues; other site 862719015725 oxalacetate/citrate binding site [chemical binding]; other site 862719015726 coenzyme A binding site [chemical binding]; other site 862719015727 catalytic triad [active] 862719015728 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719015729 GAF domain; Region: GAF; cl15785 862719015730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015731 PAS fold; Region: PAS_3; pfam08447 862719015732 putative active site [active] 862719015733 heme pocket [chemical binding]; other site 862719015734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015735 PAS fold; Region: PAS_3; pfam08447 862719015736 putative active site [active] 862719015737 heme pocket [chemical binding]; other site 862719015738 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719015739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015740 dimer interface [polypeptide binding]; other site 862719015741 phosphorylation site [posttranslational modification] 862719015742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015743 ATP binding site [chemical binding]; other site 862719015744 Mg2+ binding site [ion binding]; other site 862719015745 G-X-G motif; other site 862719015746 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 862719015747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015748 active site 862719015749 phosphorylation site [posttranslational modification] 862719015750 intermolecular recognition site; other site 862719015751 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015753 active site 862719015754 phosphorylation site [posttranslational modification] 862719015755 intermolecular recognition site; other site 862719015756 dimerization interface [polypeptide binding]; other site 862719015757 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719015758 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719015759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015760 active site 862719015761 phosphorylation site [posttranslational modification] 862719015762 intermolecular recognition site; other site 862719015763 dimerization interface [polypeptide binding]; other site 862719015764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015765 Walker A motif; other site 862719015766 ATP binding site [chemical binding]; other site 862719015767 Walker B motif; other site 862719015768 arginine finger; other site 862719015769 Helix-turn-helix domains; Region: HTH; cl00088 862719015770 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 862719015771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719015772 DNA-binding site [nucleotide binding]; DNA binding site 862719015773 FCD domain; Region: FCD; cl11656 862719015774 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719015775 FAD binding domain; Region: FAD_binding_4; pfam01565 862719015776 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862719015777 Cysteine-rich domain; Region: CCG; pfam02754 862719015778 Cysteine-rich domain; Region: CCG; pfam02754 862719015779 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 862719015780 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 862719015781 4Fe-4S binding domain; Region: Fer4; cl02805 862719015782 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 862719015783 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 862719015784 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 862719015785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719015786 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 862719015787 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862719015788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015789 Walker A motif; other site 862719015790 ATP binding site [chemical binding]; other site 862719015791 Walker B motif; other site 862719015792 arginine finger; other site 862719015793 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 862719015794 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 862719015795 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719015796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015797 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 862719015798 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 862719015799 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 862719015800 Fe-S cluster binding site [ion binding]; other site 862719015801 active site 862719015802 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 862719015803 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719015804 catalytic residue [active] 862719015805 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 862719015806 MPT binding site; other site 862719015807 trimer interface [polypeptide binding]; other site 862719015808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015809 TPR motif; other site 862719015810 binding surface 862719015811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719015812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015813 binding surface 862719015814 TPR motif; other site 862719015815 TPR repeat; Region: TPR_11; pfam13414 862719015816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015817 binding surface 862719015818 TPR motif; other site 862719015819 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719015820 octamerization interface [polypeptide binding]; other site 862719015821 diferric-oxygen binding site [ion binding]; other site 862719015822 Fic family protein [Function unknown]; Region: COG3177 862719015823 Fic/DOC family; Region: Fic; cl00960 862719015824 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 862719015825 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 862719015826 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 862719015827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719015828 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 862719015829 active site 862719015830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719015831 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 862719015832 Protein of unknown function, DUF482; Region: DUF482; pfam04339 862719015833 hypothetical protein; Provisional; Region: PRK13560 862719015834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719015835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719015836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015837 dimer interface [polypeptide binding]; other site 862719015838 phosphorylation site [posttranslational modification] 862719015839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015840 ATP binding site [chemical binding]; other site 862719015841 Mg2+ binding site [ion binding]; other site 862719015842 G-X-G motif; other site 862719015843 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419 862719015844 Protein of unknown function (DUF330); Region: DUF330; cl01135 862719015845 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 862719015846 mce related protein; Region: MCE; pfam02470 862719015847 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 862719015848 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 862719015849 Walker A/P-loop; other site 862719015850 ATP binding site [chemical binding]; other site 862719015851 Q-loop/lid; other site 862719015852 ABC transporter signature motif; other site 862719015853 Walker B; other site 862719015854 D-loop; other site 862719015855 H-loop/switch region; other site 862719015856 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 862719015857 Permease; Region: Permease; cl00510 862719015858 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719015859 active site 862719015860 DoxX; Region: DoxX; cl00976 862719015861 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719015862 EamA-like transporter family; Region: EamA; cl01037 862719015863 EamA-like transporter family; Region: EamA; cl01037 862719015864 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719015865 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 862719015866 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 862719015867 metal binding site [ion binding]; metal-binding site 862719015868 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 862719015869 GIY-YIG motif/motif A; other site 862719015870 putative active site [active] 862719015871 putative metal binding site [ion binding]; other site 862719015872 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 862719015873 CHASE domain; Region: CHASE; cl01369 862719015874 PAS domain S-box; Region: sensory_box; TIGR00229 862719015875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719015876 metal binding site [ion binding]; metal-binding site 862719015877 active site 862719015878 I-site; other site 862719015879 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719015880 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 862719015881 heme-binding site [chemical binding]; other site 862719015882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015884 dimer interface [polypeptide binding]; other site 862719015885 putative CheW interface [polypeptide binding]; other site 862719015886 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 862719015887 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 862719015888 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862719015889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719015890 active site 862719015891 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 862719015892 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 862719015893 replicative DNA helicase; Provisional; Region: PRK09165 862719015894 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862719015895 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862719015896 Walker A motif; other site 862719015897 ATP binding site [chemical binding]; other site 862719015898 Walker B motif; other site 862719015899 DNA binding loops [nucleotide binding] 862719015900 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 862719015901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 862719015902 active site 862719015903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719015904 dimer interface [polypeptide binding]; other site 862719015905 substrate binding site [chemical binding]; other site 862719015906 catalytic residues [active] 862719015907 Permease; Region: Permease; cl00510 862719015908 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 862719015909 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 862719015910 Walker A/P-loop; other site 862719015911 ATP binding site [chemical binding]; other site 862719015912 Q-loop/lid; other site 862719015913 ABC transporter signature motif; other site 862719015914 Walker B; other site 862719015915 D-loop; other site 862719015916 H-loop/switch region; other site 862719015917 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 862719015918 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 862719015919 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719015920 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 862719015921 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 862719015922 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719015923 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719015924 Ligand binding site [chemical binding]; other site 862719015925 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 862719015926 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719015927 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719015928 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 862719015929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015930 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719015931 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 862719015932 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 862719015933 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 862719015934 Trp docking motif [polypeptide binding]; other site 862719015935 putative active site [active] 862719015936 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 862719015937 allantoate amidohydrolase; Reviewed; Region: PRK09290 862719015938 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 862719015939 active site 862719015940 metal binding site [ion binding]; metal-binding site 862719015941 dimer interface [polypeptide binding]; other site 862719015942 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 862719015943 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 862719015944 putative metal binding site [ion binding]; other site 862719015945 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 862719015946 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 862719015947 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 862719015948 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 862719015949 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 862719015950 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 862719015951 dimer interface [polypeptide binding]; other site 862719015952 motif 1; other site 862719015953 active site 862719015954 motif 2; other site 862719015955 motif 3; other site 862719015956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719015957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719015958 active site 862719015959 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719015960 active site 862719015961 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719015962 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 862719015963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719015964 dimerization interface [polypeptide binding]; other site 862719015965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719015966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015967 dimer interface [polypeptide binding]; other site 862719015968 putative CheW interface [polypeptide binding]; other site 862719015969 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719015970 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719015971 ligand binding site [chemical binding]; other site 862719015972 flexible hinge region; other site 862719015973 Helix-turn-helix domains; Region: HTH; cl00088 862719015974 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 862719015975 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862719015976 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 862719015977 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719015978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015979 alpha-galactosidase; Provisional; Region: PRK15076 862719015980 NAD(P) binding site [chemical binding]; other site 862719015981 LDH/MDH dimer interface [polypeptide binding]; other site 862719015982 substrate binding site [chemical binding]; other site 862719015983 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719015984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719015985 putative substrate translocation pore; other site 862719015986 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 862719015987 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 862719015988 Proline dehydrogenase; Region: Pro_dh; cl03282 862719015989 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 862719015990 Glutamate binding site [chemical binding]; other site 862719015991 NAD binding site [chemical binding]; other site 862719015992 catalytic residues [active] 862719015993 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 862719015994 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 862719015995 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 862719015996 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 862719015997 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 862719015998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719015999 NAD binding site [chemical binding]; other site 862719016000 catalytic Zn binding site [ion binding]; other site 862719016001 structural Zn binding site [ion binding]; other site 862719016002 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 862719016003 active site 862719016004 catalytic triad [active] 862719016005 dimer interface [polypeptide binding]; other site 862719016006 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862719016007 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719016008 metabolite-proton symporter; Region: 2A0106; TIGR00883 862719016009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 862719016010 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 862719016011 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 862719016012 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 862719016013 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 862719016014 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 862719016015 D-pathway; other site 862719016016 Putative ubiquinol binding site [chemical binding]; other site 862719016017 Low-spin heme (heme b) binding site [chemical binding]; other site 862719016018 Putative water exit pathway; other site 862719016019 Binuclear center (heme o3/CuB) [ion binding]; other site 862719016020 K-pathway; other site 862719016021 Putative proton exit pathway; other site 862719016022 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 862719016023 Subunit I/III interface [polypeptide binding]; other site 862719016024 Subunit III/IV interface [polypeptide binding]; other site 862719016025 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 862719016026 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 862719016027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719016028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016029 dimer interface [polypeptide binding]; other site 862719016030 phosphorylation site [posttranslational modification] 862719016031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016032 ATP binding site [chemical binding]; other site 862719016033 Mg2+ binding site [ion binding]; other site 862719016034 G-X-G motif; other site 862719016035 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 862719016036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016037 active site 862719016038 phosphorylation site [posttranslational modification] 862719016039 intermolecular recognition site; other site 862719016040 dimerization interface [polypeptide binding]; other site 862719016041 Helix-turn-helix domains; Region: HTH; cl00088 862719016042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719016043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719016044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719016045 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719016046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719016047 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719016048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719016049 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719016050 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862719016051 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862719016052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719016053 FeS/SAM binding site; other site 862719016054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016055 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862719016056 NAD(P) binding site [chemical binding]; other site 862719016057 active site 862719016058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719016059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016060 NAD(P) binding site [chemical binding]; other site 862719016061 active site 862719016062 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 862719016063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719016064 catalytic core [active] 862719016065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719016066 S-adenosylmethionine binding site [chemical binding]; other site 862719016067 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 862719016068 Ion channel; Region: Ion_trans_2; cl11596 862719016069 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 862719016070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016071 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 862719016072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016073 NlpC/P60 family; Region: NLPC_P60; cl11438 862719016074 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 862719016075 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 862719016076 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 862719016077 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719016078 [4Fe-4S] binding site [ion binding]; other site 862719016079 molybdopterin cofactor binding site; other site 862719016080 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719016081 molybdopterin cofactor binding site; other site 862719016082 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719016083 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 862719016084 [2Fe-2S] cluster binding site [ion binding]; other site 862719016085 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 862719016086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719016087 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719016088 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862719016089 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719016090 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719016091 NMT1-like family; Region: NMT1_2; cl15260 862719016092 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719016093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016094 dimer interface [polypeptide binding]; other site 862719016095 conserved gate region; other site 862719016096 putative PBP binding loops; other site 862719016097 ABC-ATPase subunit interface; other site 862719016098 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719016099 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719016100 Walker A/P-loop; other site 862719016101 ATP binding site [chemical binding]; other site 862719016102 Q-loop/lid; other site 862719016103 ABC transporter signature motif; other site 862719016104 Walker B; other site 862719016105 D-loop; other site 862719016106 H-loop/switch region; other site 862719016107 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 862719016108 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 862719016109 Walker A/P-loop; other site 862719016110 ATP binding site [chemical binding]; other site 862719016111 Q-loop/lid; other site 862719016112 ABC transporter signature motif; other site 862719016113 Walker B; other site 862719016114 D-loop; other site 862719016115 H-loop/switch region; other site 862719016116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719016117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719016118 active site 862719016119 catalytic tetrad [active] 862719016120 Uncharacterized conserved protein [Function unknown]; Region: COG4715 862719016121 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862719016122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719016123 ATP binding site [chemical binding]; other site 862719016124 putative Mg++ binding site [ion binding]; other site 862719016125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719016126 nucleotide binding region [chemical binding]; other site 862719016127 ATP-binding site [chemical binding]; other site 862719016128 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8763924; Product type e : enzyme 862719016129 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 862719016130 putative active site [active] 862719016131 catalytic site [active] 862719016132 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 862719016133 putative active site [active] 862719016134 catalytic site [active] 862719016135 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 862719016136 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 862719016137 active site 862719016138 catalytic residues [active] 862719016139 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719016140 TM-ABC transporter signature motif; other site 862719016141 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719016142 TM-ABC transporter signature motif; other site 862719016143 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719016144 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719016145 Walker A/P-loop; other site 862719016146 ATP binding site [chemical binding]; other site 862719016147 Q-loop/lid; other site 862719016148 ABC transporter signature motif; other site 862719016149 Walker B; other site 862719016150 D-loop; other site 862719016151 H-loop/switch region; other site 862719016152 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719016153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 862719016154 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 862719016155 putative ligand binding site [chemical binding]; other site 862719016156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 862719016157 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719016158 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 862719016159 dimer interface [polypeptide binding]; other site 862719016160 NADP binding site [chemical binding]; other site 862719016161 catalytic residues [active] 862719016162 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 862719016163 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 862719016164 inhibitor site; inhibition site 862719016165 active site 862719016166 dimer interface [polypeptide binding]; other site 862719016167 catalytic residue [active] 862719016168 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 862719016169 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 862719016170 Helix-turn-helix domains; Region: HTH; cl00088 862719016171 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 862719016172 putative dimerization interface [polypeptide binding]; other site 862719016173 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 862719016174 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 862719016175 putative ligand binding site [chemical binding]; other site 862719016176 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 862719016177 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862719016178 Walker A/P-loop; other site 862719016179 ATP binding site [chemical binding]; other site 862719016180 Q-loop/lid; other site 862719016181 ABC transporter signature motif; other site 862719016182 Walker B; other site 862719016183 D-loop; other site 862719016184 H-loop/switch region; other site 862719016185 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862719016186 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719016187 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719016188 TM-ABC transporter signature motif; other site 862719016189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719016190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016191 Dehydratase family; Region: ILVD_EDD; cl00340 862719016192 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862719016193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862719016194 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862719016195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719016196 PAS domain S-box; Region: sensory_box; TIGR00229 862719016197 PAS fold; Region: PAS; pfam00989 862719016198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719016199 hypothetical protein; Provisional; Region: PRK13560 862719016200 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719016201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719016202 metal binding site [ion binding]; metal-binding site 862719016203 active site 862719016204 I-site; other site 862719016205 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719016206 Protein export membrane protein; Region: SecD_SecF; cl14618 862719016207 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 862719016208 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719016209 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719016210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719016211 Helix-turn-helix domains; Region: HTH; cl00088 862719016212 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719016213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719016214 Ligand Binding Site [chemical binding]; other site 862719016215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719016216 Helix-turn-helix domains; Region: HTH; cl00088 862719016217 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719016218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719016219 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 862719016220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719016221 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719016222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016223 dimer interface [polypeptide binding]; other site 862719016224 conserved gate region; other site 862719016225 putative PBP binding loops; other site 862719016226 ABC-ATPase subunit interface; other site 862719016227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719016228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016229 dimer interface [polypeptide binding]; other site 862719016230 conserved gate region; other site 862719016231 putative PBP binding loops; other site 862719016232 ABC-ATPase subunit interface; other site 862719016233 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719016234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719016235 substrate binding pocket [chemical binding]; other site 862719016236 membrane-bound complex binding site; other site 862719016237 hinge residues; other site 862719016238 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719016239 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 862719016240 Walker A/P-loop; other site 862719016241 ATP binding site [chemical binding]; other site 862719016242 Q-loop/lid; other site 862719016243 ABC transporter signature motif; other site 862719016244 Walker B; other site 862719016245 D-loop; other site 862719016246 H-loop/switch region; other site 862719016247 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719016248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719016250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719016251 DNA binding site [nucleotide binding] 862719016252 domain linker motif; other site 862719016253 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 862719016254 putative dimerization interface [polypeptide binding]; other site 862719016255 putative ligand binding site [chemical binding]; other site 862719016256 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719016257 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 862719016258 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 862719016259 DNA binding residues [nucleotide binding] 862719016260 dimer interface [polypeptide binding]; other site 862719016261 [2Fe-2S] cluster binding site [ion binding]; other site 862719016262 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 862719016263 HPP family; Region: HPP; pfam04982 862719016264 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719016265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 862719016266 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719016267 Cation efflux family; Region: Cation_efflux; cl00316 862719016268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862719016269 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719016270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719016271 P-loop; other site 862719016272 Magnesium ion binding site [ion binding]; other site 862719016273 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719016274 Magnesium ion binding site [ion binding]; other site 862719016275 ParB-like partition proteins; Region: parB_part; TIGR00180 862719016276 ParB-like nuclease domain; Region: ParBc; cl02129 862719016277 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719016278 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 862719016279 heme binding pocket [chemical binding]; other site 862719016280 malonyl-CoA synthase; Validated; Region: PRK07514 862719016281 AMP-binding enzyme; Region: AMP-binding; cl15778 862719016282 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719016283 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 862719016284 NodB motif; other site 862719016285 active site 862719016286 catalytic site [active] 862719016287 metal binding site [ion binding]; metal-binding site 862719016288 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 862719016289 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862719016290 Histidine kinase; Region: His_kinase; pfam06580 862719016291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016292 ATP binding site [chemical binding]; other site 862719016293 Mg2+ binding site [ion binding]; other site 862719016294 G-X-G motif; other site 862719016295 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 862719016296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016297 active site 862719016298 phosphorylation site [posttranslational modification] 862719016299 intermolecular recognition site; other site 862719016300 dimerization interface [polypeptide binding]; other site 862719016301 LytTr DNA-binding domain; Region: LytTR; cl04498 862719016302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719016303 Helix-turn-helix domains; Region: HTH; cl00088 862719016304 potential frameshift: common BLAST hit: gi|288962344|ref|YP_003452639.1| secretion protein 862719016305 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719016306 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719016307 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 862719016308 multidrug efflux protein; Reviewed; Region: PRK09579 862719016309 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719016310 NMT1-like family; Region: NMT1_2; cl15260 862719016311 Right handed beta helix region; Region: Beta_helix; pfam13229 862719016312 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 862719016313 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 862719016314 Protein of unknown function (DUF466); Region: DUF466; cl01082 862719016315 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 862719016316 Carbon starvation protein CstA; Region: CstA; pfam02554 862719016317 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 862719016318 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 862719016319 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 862719016320 HflX GTPase family; Region: HflX; cd01878 862719016321 G1 box; other site 862719016322 GTP/Mg2+ binding site [chemical binding]; other site 862719016323 Switch I region; other site 862719016324 G2 box; other site 862719016325 G3 box; other site 862719016326 Switch II region; other site 862719016327 G4 box; other site 862719016328 G5 box; other site 862719016329 L-lactate permease; Region: Lactate_perm; cl00701 862719016330 L-lactate permease; Region: Lactate_perm; cl00701 862719016331 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 862719016332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 862719016333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719016334 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 862719016335 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862719016336 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 862719016337 PAS fold; Region: PAS_4; pfam08448 862719016338 GAF domain; Region: GAF; cl15785 862719016339 sensory histidine kinase AtoS; Provisional; Region: PRK11360 862719016340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016341 dimer interface [polypeptide binding]; other site 862719016342 phosphorylation site [posttranslational modification] 862719016343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016344 ATP binding site [chemical binding]; other site 862719016345 G-X-G motif; other site 862719016346 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016348 active site 862719016349 phosphorylation site [posttranslational modification] 862719016350 intermolecular recognition site; other site 862719016351 dimerization interface [polypeptide binding]; other site 862719016352 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862719016353 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 862719016354 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141