-- dump date 20120504_133648 -- class Genbank::misc_feature -- table misc_feature_note -- id note 692420000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 692420000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 692420000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000004 Walker A motif; other site 692420000005 ATP binding site [chemical binding]; other site 692420000006 Walker B motif; other site 692420000007 arginine finger; other site 692420000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 692420000009 DnaA box-binding interface [nucleotide binding]; other site 692420000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 692420000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 692420000012 putative DNA binding surface [nucleotide binding]; other site 692420000013 dimer interface [polypeptide binding]; other site 692420000014 beta-clamp/clamp loader binding surface; other site 692420000015 beta-clamp/translesion DNA polymerase binding surface; other site 692420000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 692420000017 recombination protein F; Reviewed; Region: recF; PRK00064 692420000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 692420000019 Walker A/P-loop; other site 692420000020 ATP binding site [chemical binding]; other site 692420000021 Q-loop/lid; other site 692420000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420000023 ABC transporter signature motif; other site 692420000024 Walker B; other site 692420000025 D-loop; other site 692420000026 H-loop/switch region; other site 692420000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 692420000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420000029 ATP binding site [chemical binding]; other site 692420000030 Mg2+ binding site [ion binding]; other site 692420000031 G-X-G motif; other site 692420000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 692420000033 anchoring element; other site 692420000034 dimer interface [polypeptide binding]; other site 692420000035 ATP binding site [chemical binding]; other site 692420000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 692420000037 active site 692420000038 putative metal-binding site [ion binding]; other site 692420000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 692420000040 DNA gyrase subunit A; Validated; Region: PRK05560 692420000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 692420000042 CAP-like domain; other site 692420000043 active site 692420000044 primary dimer interface [polypeptide binding]; other site 692420000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000051 YaaC-like Protein; Region: YaaC; pfam14175 692420000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 692420000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 692420000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 692420000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 692420000056 active site 692420000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 692420000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 692420000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 692420000062 active site 692420000063 multimer interface [polypeptide binding]; other site 692420000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 692420000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 692420000066 predicted active site [active] 692420000067 catalytic triad [active] 692420000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 692420000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 692420000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 692420000071 dimer interface [polypeptide binding]; other site 692420000072 active site 692420000073 motif 1; other site 692420000074 motif 2; other site 692420000075 motif 3; other site 692420000076 Glycerate kinase family; Region: Gly_kinase; cl00841 692420000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 692420000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 692420000079 Substrate-binding site [chemical binding]; other site 692420000080 Substrate specificity [chemical binding]; other site 692420000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 692420000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 692420000083 Substrate-binding site [chemical binding]; other site 692420000084 Substrate specificity [chemical binding]; other site 692420000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 692420000086 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420000087 putative peptidoglycan binding site; other site 692420000088 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420000089 putative peptidoglycan binding site; other site 692420000090 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 692420000091 active site 692420000092 Isochorismatase family; Region: Isochorismatase; pfam00857 692420000093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420000094 catalytic triad [active] 692420000095 conserved cis-peptide bond; other site 692420000096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 692420000097 nucleoside/Zn binding site; other site 692420000098 dimer interface [polypeptide binding]; other site 692420000099 catalytic motif [active] 692420000100 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 692420000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000102 Walker A motif; other site 692420000103 ATP binding site [chemical binding]; other site 692420000104 Walker B motif; other site 692420000105 arginine finger; other site 692420000106 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 692420000107 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 692420000108 recombination protein RecR; Reviewed; Region: recR; PRK00076 692420000109 RecR protein; Region: RecR; pfam02132 692420000110 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 692420000111 putative active site [active] 692420000112 putative metal-binding site [ion binding]; other site 692420000113 tetramer interface [polypeptide binding]; other site 692420000114 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 692420000115 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 692420000116 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 692420000117 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 692420000118 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 692420000119 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 692420000120 homodimer interface [polypeptide binding]; other site 692420000121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000122 catalytic residue [active] 692420000123 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 692420000124 thymidylate kinase; Validated; Region: tmk; PRK00698 692420000125 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 692420000126 TMP-binding site; other site 692420000127 ATP-binding site [chemical binding]; other site 692420000128 Nitrogen regulatory protein P-II; Region: P-II; cl00412 692420000129 Protein of unknown function (DUF327); Region: DUF327; cl00753 692420000130 DNA polymerase III subunit delta'; Validated; Region: PRK08058 692420000131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420000132 PSP1 C-terminal conserved region; Region: PSP1; cl00770 692420000133 TSC-22/dip/bun family; Region: TSC22; cl01853 692420000134 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 692420000135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000136 S-adenosylmethionine binding site [chemical binding]; other site 692420000137 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 692420000138 GIY-YIG motif/motif A; other site 692420000139 putative active site [active] 692420000140 putative metal binding site [ion binding]; other site 692420000141 Predicted methyltransferases [General function prediction only]; Region: COG0313 692420000142 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 692420000143 stage V sporulation protein T; Region: spore_V_T; TIGR02851 692420000144 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 692420000145 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 692420000146 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 692420000147 active site 692420000148 HIGH motif; other site 692420000149 KMSKS motif; other site 692420000150 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 692420000151 tRNA binding surface [nucleotide binding]; other site 692420000152 anticodon binding site; other site 692420000153 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 692420000154 dimer interface [polypeptide binding]; other site 692420000155 putative tRNA-binding site [nucleotide binding]; other site 692420000156 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 692420000157 active site 692420000158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 692420000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000162 G5 domain; Region: G5; pfam07501 692420000163 3D domain; Region: 3D; cl01439 692420000164 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 692420000165 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 692420000166 putative active site [active] 692420000167 putative metal binding site [ion binding]; other site 692420000168 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 692420000169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000170 S-adenosylmethionine binding site [chemical binding]; other site 692420000171 YabG peptidase U57; Region: Peptidase_U57; cl05250 692420000172 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 692420000173 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420000174 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 692420000175 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420000176 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420000177 pur operon repressor; Provisional; Region: PRK09213 692420000178 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 692420000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000180 active site 692420000181 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 692420000182 homotrimer interaction site [polypeptide binding]; other site 692420000183 putative active site [active] 692420000184 SpoVG; Region: SpoVG; cl00915 692420000185 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 692420000186 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 692420000187 Substrate binding site; other site 692420000188 Mg++ binding site; other site 692420000189 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 692420000190 active site 692420000191 substrate binding site [chemical binding]; other site 692420000192 CoA binding site [chemical binding]; other site 692420000193 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 692420000194 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 692420000195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000196 active site 692420000197 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 692420000198 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 692420000199 5S rRNA interface [nucleotide binding]; other site 692420000200 CTC domain interface [polypeptide binding]; other site 692420000201 L16 interface [polypeptide binding]; other site 692420000202 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 692420000203 putative active site [active] 692420000204 catalytic residue [active] 692420000205 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 692420000206 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 692420000207 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 692420000208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420000209 ATP binding site [chemical binding]; other site 692420000210 putative Mg++ binding site [ion binding]; other site 692420000211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420000212 nucleotide binding region [chemical binding]; other site 692420000213 ATP-binding site [chemical binding]; other site 692420000214 TRCF domain; Region: TRCF; cl04088 692420000215 stage V sporulation protein T; Region: spore_V_T; TIGR02851 692420000216 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 692420000217 MatE; Region: MatE; cl10513 692420000218 MatE; Region: MatE; cl10513 692420000219 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 692420000220 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 692420000221 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 692420000222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420000223 RNA binding surface [nucleotide binding]; other site 692420000224 YabP family; Region: YabP; cl06766 692420000225 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 692420000226 Septum formation initiator; Region: DivIC; cl11433 692420000227 hypothetical protein; Provisional; Region: PRK08582 692420000228 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 692420000229 RNA binding site [nucleotide binding]; other site 692420000230 stage II sporulation protein E; Region: spore_II_E; TIGR02865 692420000231 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 692420000232 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 692420000233 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 692420000234 metal ion-dependent adhesion site (MIDAS); other site 692420000235 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420000236 active site 692420000237 ATP binding site [chemical binding]; other site 692420000238 substrate binding site [chemical binding]; other site 692420000239 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 692420000240 Ligand Binding Site [chemical binding]; other site 692420000241 B3/4 domain; Region: B3_4; cl11458 692420000242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000243 active site 692420000244 FtsH Extracellular; Region: FtsH_ext; pfam06480 692420000245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 692420000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000247 Walker A motif; other site 692420000248 ATP binding site [chemical binding]; other site 692420000249 Walker B motif; other site 692420000250 arginine finger; other site 692420000251 Peptidase family M41; Region: Peptidase_M41; pfam01434 692420000252 Type III pantothenate kinase; Region: Pan_kinase; cl09130 692420000253 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 692420000254 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 692420000255 dimerization interface [polypeptide binding]; other site 692420000256 domain crossover interface; other site 692420000257 redox-dependent activation switch; other site 692420000258 SurA N-terminal domain; Region: SurA_N_3; cl07813 692420000259 PPIC-type PPIASE domain; Region: Rotamase; cl08278 692420000260 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420000261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420000262 dimer interface [polypeptide binding]; other site 692420000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000264 catalytic residue [active] 692420000265 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 692420000266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 692420000267 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420000268 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 692420000269 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 692420000270 glutamine binding [chemical binding]; other site 692420000271 catalytic triad [active] 692420000272 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 692420000273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000274 catalytic residue [active] 692420000275 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 692420000276 dihydropteroate synthase; Region: DHPS; TIGR01496 692420000277 substrate binding pocket [chemical binding]; other site 692420000278 dimer interface [polypeptide binding]; other site 692420000279 inhibitor binding site; inhibition site 692420000280 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 692420000281 homooctamer interface [polypeptide binding]; other site 692420000282 active site 692420000283 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 692420000284 catalytic center binding site [active] 692420000285 ATP binding site [chemical binding]; other site 692420000286 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 692420000287 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 692420000288 FMN binding site [chemical binding]; other site 692420000289 active site 692420000290 catalytic residues [active] 692420000291 substrate binding site [chemical binding]; other site 692420000292 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 692420000293 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 692420000294 dimer interface [polypeptide binding]; other site 692420000295 putative anticodon binding site; other site 692420000296 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 692420000297 motif 1; other site 692420000298 active site 692420000299 motif 2; other site 692420000300 motif 3; other site 692420000301 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 692420000302 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 692420000303 UvrB/uvrC motif; Region: UVR; pfam02151 692420000304 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 692420000305 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 692420000306 ADP binding site [chemical binding]; other site 692420000307 phosphagen binding site; other site 692420000308 substrate specificity loop; other site 692420000309 Clp protease ATP binding subunit; Region: clpC; CHL00095 692420000310 Clp amino terminal domain; Region: Clp_N; pfam02861 692420000311 Clp amino terminal domain; Region: Clp_N; pfam02861 692420000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000313 Walker A motif; other site 692420000314 ATP binding site [chemical binding]; other site 692420000315 Walker B motif; other site 692420000316 arginine finger; other site 692420000317 UvrB/uvrC motif; Region: UVR; pfam02151 692420000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000319 Walker A motif; other site 692420000320 ATP binding site [chemical binding]; other site 692420000321 Walker B motif; other site 692420000322 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 692420000323 DNA repair protein RadA; Provisional; Region: PRK11823 692420000324 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 692420000325 Walker A motif/ATP binding site; other site 692420000326 ATP binding site [chemical binding]; other site 692420000327 Walker B motif; other site 692420000328 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 692420000329 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 692420000330 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420000331 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 692420000332 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 692420000333 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 692420000334 putative active site [active] 692420000335 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 692420000336 substrate binding site; other site 692420000337 dimer interface; other site 692420000338 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 692420000339 homotrimer interaction site [polypeptide binding]; other site 692420000340 zinc binding site [ion binding]; other site 692420000341 CDP-binding sites; other site 692420000342 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 692420000343 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 692420000344 HIGH motif; other site 692420000345 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 692420000346 active site 692420000347 KMSKS motif; other site 692420000348 serine O-acetyltransferase; Region: cysE; TIGR01172 692420000349 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 692420000350 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 692420000351 trimer interface [polypeptide binding]; other site 692420000352 active site 692420000353 substrate binding site [chemical binding]; other site 692420000354 CoA binding site [chemical binding]; other site 692420000355 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 692420000356 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 692420000357 active site 692420000358 HIGH motif; other site 692420000359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 692420000360 KMSKS motif; other site 692420000361 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 692420000362 tRNA binding surface [nucleotide binding]; other site 692420000363 anticodon binding site; other site 692420000364 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 692420000365 active site 692420000366 metal binding site [ion binding]; metal-binding site 692420000367 dimerization interface [polypeptide binding]; other site 692420000368 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 692420000369 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 692420000370 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 692420000371 YacP-like NYN domain; Region: NYN_YacP; cl01491 692420000372 RNA polymerase factor sigma-70; Validated; Region: PRK08295 692420000373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420000374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420000375 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 692420000376 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 692420000377 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 692420000378 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 692420000379 putative homodimer interface [polypeptide binding]; other site 692420000380 KOW motif; Region: KOW; cl00354 692420000381 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 692420000382 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 692420000383 23S rRNA interface [nucleotide binding]; other site 692420000384 L7/L12 interface [polypeptide binding]; other site 692420000385 putative thiostrepton binding site; other site 692420000386 L25 interface [polypeptide binding]; other site 692420000387 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 692420000388 mRNA/rRNA interface [nucleotide binding]; other site 692420000389 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 692420000390 23S rRNA interface [nucleotide binding]; other site 692420000391 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 692420000392 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 692420000393 core dimer interface [polypeptide binding]; other site 692420000394 peripheral dimer interface [polypeptide binding]; other site 692420000395 L10 interface [polypeptide binding]; other site 692420000396 L11 interface [polypeptide binding]; other site 692420000397 putative EF-Tu interaction site [polypeptide binding]; other site 692420000398 putative EF-G interaction site [polypeptide binding]; other site 692420000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000400 S-adenosylmethionine binding site [chemical binding]; other site 692420000401 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 692420000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 692420000403 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 692420000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 692420000405 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 692420000406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 692420000407 RPB1 interaction site [polypeptide binding]; other site 692420000408 RPB10 interaction site [polypeptide binding]; other site 692420000409 RPB11 interaction site [polypeptide binding]; other site 692420000410 RPB3 interaction site [polypeptide binding]; other site 692420000411 RPB12 interaction site [polypeptide binding]; other site 692420000412 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 692420000413 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 692420000414 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 692420000415 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 692420000416 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 692420000417 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 692420000418 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 692420000419 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 692420000420 G-loop; other site 692420000421 DNA binding site [nucleotide binding] 692420000422 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 692420000423 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 692420000424 S17 interaction site [polypeptide binding]; other site 692420000425 S8 interaction site; other site 692420000426 16S rRNA interaction site [nucleotide binding]; other site 692420000427 streptomycin interaction site [chemical binding]; other site 692420000428 23S rRNA interaction site [nucleotide binding]; other site 692420000429 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 692420000430 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 692420000431 elongation factor G; Reviewed; Region: PRK00007 692420000432 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 692420000433 G1 box; other site 692420000434 putative GEF interaction site [polypeptide binding]; other site 692420000435 GTP/Mg2+ binding site [chemical binding]; other site 692420000436 Switch I region; other site 692420000437 G2 box; other site 692420000438 G3 box; other site 692420000439 Switch II region; other site 692420000440 G4 box; other site 692420000441 G5 box; other site 692420000442 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 692420000443 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 692420000444 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 692420000445 elongation factor Tu; Reviewed; Region: PRK00049 692420000446 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 692420000447 G1 box; other site 692420000448 GEF interaction site [polypeptide binding]; other site 692420000449 GTP/Mg2+ binding site [chemical binding]; other site 692420000450 Switch I region; other site 692420000451 G2 box; other site 692420000452 G3 box; other site 692420000453 Switch II region; other site 692420000454 G4 box; other site 692420000455 G5 box; other site 692420000456 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 692420000457 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 692420000458 Antibiotic Binding Site [chemical binding]; other site 692420000459 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420000460 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 692420000461 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 692420000462 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 692420000463 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 692420000464 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 692420000465 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 692420000466 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 692420000467 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 692420000468 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 692420000469 putative translocon binding site; other site 692420000470 protein-rRNA interface [nucleotide binding]; other site 692420000471 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 692420000472 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 692420000473 G-X-X-G motif; other site 692420000474 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 692420000475 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 692420000476 23S rRNA interface [nucleotide binding]; other site 692420000477 5S rRNA interface [nucleotide binding]; other site 692420000478 putative antibiotic binding site [chemical binding]; other site 692420000479 L25 interface [polypeptide binding]; other site 692420000480 L27 interface [polypeptide binding]; other site 692420000481 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 692420000482 23S rRNA interface [nucleotide binding]; other site 692420000483 putative translocon interaction site; other site 692420000484 signal recognition particle (SRP54) interaction site; other site 692420000485 L23 interface [polypeptide binding]; other site 692420000486 trigger factor interaction site; other site 692420000487 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 692420000488 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 692420000489 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 692420000490 KOW motif; Region: KOW; cl00354 692420000491 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 692420000492 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 692420000493 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 692420000494 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 692420000495 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 692420000496 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 692420000497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 692420000498 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 692420000499 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 692420000500 5S rRNA interface [nucleotide binding]; other site 692420000501 L27 interface [polypeptide binding]; other site 692420000502 23S rRNA interface [nucleotide binding]; other site 692420000503 L5 interface [polypeptide binding]; other site 692420000504 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 692420000505 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 692420000506 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 692420000507 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 692420000508 23S rRNA binding site [nucleotide binding]; other site 692420000509 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 692420000510 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 692420000511 SecY translocase; Region: SecY; pfam00344 692420000512 adenylate kinase; Reviewed; Region: adk; PRK00279 692420000513 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 692420000514 AMP-binding site [chemical binding]; other site 692420000515 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 692420000516 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 692420000517 active site 692420000518 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 692420000519 rRNA binding site [nucleotide binding]; other site 692420000520 predicted 30S ribosome binding site; other site 692420000521 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 692420000522 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 692420000523 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 692420000524 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 692420000525 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 692420000526 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 692420000527 alphaNTD homodimer interface [polypeptide binding]; other site 692420000528 alphaNTD - beta interaction site [polypeptide binding]; other site 692420000529 alphaNTD - beta' interaction site [polypeptide binding]; other site 692420000530 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 692420000531 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 692420000532 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 692420000533 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 692420000534 Walker A/P-loop; other site 692420000535 ATP binding site [chemical binding]; other site 692420000536 Q-loop/lid; other site 692420000537 ABC transporter signature motif; other site 692420000538 Walker B; other site 692420000539 D-loop; other site 692420000540 H-loop/switch region; other site 692420000541 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 692420000542 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 692420000543 Walker A/P-loop; other site 692420000544 ATP binding site [chemical binding]; other site 692420000545 Q-loop/lid; other site 692420000546 ABC transporter signature motif; other site 692420000547 Walker B; other site 692420000548 D-loop; other site 692420000549 H-loop/switch region; other site 692420000550 Cobalt transport protein; Region: CbiQ; cl00463 692420000551 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 692420000552 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 692420000553 dimerization interface 3.5A [polypeptide binding]; other site 692420000554 active site 692420000555 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 692420000556 23S rRNA interface [nucleotide binding]; other site 692420000557 L3 interface [polypeptide binding]; other site 692420000558 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 692420000559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 692420000560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000561 S-adenosylmethionine binding site [chemical binding]; other site 692420000562 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 692420000563 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420000564 active site 692420000565 metal binding site [ion binding]; metal-binding site 692420000566 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 692420000567 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 692420000568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420000569 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 692420000570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000571 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 692420000572 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420000573 inhibitor-cofactor binding pocket; inhibition site 692420000574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000575 catalytic residue [active] 692420000576 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 692420000577 active site 692420000578 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420000579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420000580 NAD(P) binding site [chemical binding]; other site 692420000581 Sulfate transporter family; Region: Sulfate_transp; cl15842 692420000582 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 692420000583 Sulfate transporter family; Region: Sulfate_transp; cl15842 692420000584 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 692420000585 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 692420000586 Membrane transport protein; Region: Mem_trans; cl09117 692420000587 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420000588 Putative esterase; Region: Esterase; pfam00756 692420000589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000590 ABC-ATPase subunit interface; other site 692420000591 dimer interface [polypeptide binding]; other site 692420000592 putative PBP binding regions; other site 692420000593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000594 ABC-ATPase subunit interface; other site 692420000595 dimer interface [polypeptide binding]; other site 692420000596 putative PBP binding regions; other site 692420000597 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420000598 putative ligand binding residues [chemical binding]; other site 692420000599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420000600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420000601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420000602 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 692420000603 intersubunit interface [polypeptide binding]; other site 692420000604 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 692420000605 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 692420000606 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 692420000607 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 692420000608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420000609 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 692420000610 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 692420000611 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420000612 active site turn [active] 692420000613 phosphorylation site [posttranslational modification] 692420000614 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420000615 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 692420000616 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 692420000617 putative active site [active] 692420000618 Protein of unknown function (DUF523); Region: DUF523; cl00733 692420000619 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 692420000620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420000621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420000622 DNA binding residues [nucleotide binding] 692420000623 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 692420000624 Putative zinc-finger; Region: zf-HC2; cl15806 692420000625 TIGR00159 family protein; Region: TIGR00159 692420000626 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420000627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 692420000628 YbbR-like protein; Region: YbbR; pfam07949 692420000629 YbbR-like protein; Region: YbbR; pfam07949 692420000630 YbbR-like protein; Region: YbbR; pfam07949 692420000631 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 692420000632 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 692420000633 active site 692420000634 substrate binding site [chemical binding]; other site 692420000635 metal binding site [ion binding]; metal-binding site 692420000636 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 692420000637 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 692420000638 glutaminase active site [active] 692420000639 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 692420000640 dimer interface [polypeptide binding]; other site 692420000641 active site 692420000642 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 692420000643 dimer interface [polypeptide binding]; other site 692420000644 active site 692420000645 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 692420000646 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 692420000647 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420000648 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420000649 active site 692420000650 catalytic tetrad [active] 692420000651 LrgB-like family; Region: LrgB; cl00596 692420000652 LrgA family; Region: LrgA; cl00608 692420000653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420000654 Helix-turn-helix domains; Region: HTH; cl00088 692420000655 putative transport protein YifK; Provisional; Region: PRK10746 692420000656 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 692420000657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420000658 active site 692420000659 motif I; other site 692420000660 motif II; other site 692420000661 Histidine kinase; Region: HisKA_3; pfam07730 692420000662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420000663 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420000664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420000665 active site 692420000666 phosphorylation site [posttranslational modification] 692420000667 intermolecular recognition site; other site 692420000668 dimerization interface [polypeptide binding]; other site 692420000669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420000670 DNA binding residues [nucleotide binding] 692420000671 dimerization interface [polypeptide binding]; other site 692420000672 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420000673 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420000674 Walker A/P-loop; other site 692420000675 ATP binding site [chemical binding]; other site 692420000676 Q-loop/lid; other site 692420000677 ABC transporter signature motif; other site 692420000678 Walker B; other site 692420000679 D-loop; other site 692420000680 H-loop/switch region; other site 692420000681 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 692420000682 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420000683 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420000684 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420000685 Spore germination protein; Region: Spore_permease; cl15802 692420000686 amino acid transporter; Region: 2A0306; TIGR00909 692420000687 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 692420000688 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 692420000689 active site 692420000690 catalytic site [active] 692420000691 metal binding site [ion binding]; metal-binding site 692420000692 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 692420000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000694 putative substrate translocation pore; other site 692420000695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000696 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 692420000697 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 692420000698 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 692420000699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420000700 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 692420000701 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 692420000702 active site 692420000703 NAD binding site [chemical binding]; other site 692420000704 metal binding site [ion binding]; metal-binding site 692420000705 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 692420000706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420000707 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420000708 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 692420000709 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420000710 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 692420000711 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 692420000712 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 692420000713 active site residue [active] 692420000714 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 692420000715 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420000716 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420000717 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 692420000718 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 692420000719 homodimer interface [polypeptide binding]; other site 692420000720 substrate-cofactor binding pocket; other site 692420000721 catalytic residue [active] 692420000722 S-methylmethionine transporter; Provisional; Region: PRK11387 692420000723 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 692420000724 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 692420000725 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 692420000726 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 692420000727 potential frameshift: common BLAST hit: gi|154684749|ref|YP_001419910.1| glutaminase 692420000728 Glutaminase; Region: Glutaminase; cl00907 692420000729 similar to glutaminase fragment; Glutaminase 1;, Glutaminase 692420000730 similar to glutaminase fragment; Glutaminase 692420000731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420000732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420000733 ATP binding site [chemical binding]; other site 692420000734 Mg2+ binding site [ion binding]; other site 692420000735 G-X-G motif; other site 692420000736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420000737 Response regulator receiver domain; Region: Response_reg; pfam00072 692420000738 active site 692420000739 phosphorylation site [posttranslational modification] 692420000740 intermolecular recognition site; other site 692420000741 dimerization interface [polypeptide binding]; other site 692420000742 YcbB domain; Region: YcbB; pfam08664 692420000743 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 692420000744 putative active site [active] 692420000745 putative substrate binding site [chemical binding]; other site 692420000746 Phosphotransferase enzyme family; Region: APH; pfam01636 692420000747 ATP binding site [chemical binding]; other site 692420000748 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 692420000749 dodecamer interface 2 [polypeptide binding]; other site 692420000750 dodecamer interface 1 [polypeptide binding]; other site 692420000751 trimer interface [polypeptide binding]; other site 692420000752 TRAP binding interface [polypeptide binding]; other site 692420000753 Zn binding site [ion binding]; other site 692420000754 similar to ISBma2, transposase fragment 692420000755 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420000756 Cation efflux family; Region: Cation_efflux; cl00316 692420000757 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420000758 dimer interface [polypeptide binding]; other site 692420000759 FMN binding site [chemical binding]; other site 692420000760 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420000761 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420000762 Zn binding site [ion binding]; other site 692420000763 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420000764 Zn binding site [ion binding]; other site 692420000765 DoxX; Region: DoxX; cl00976 692420000766 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420000767 catalytic residues [active] 692420000768 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 692420000769 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420000770 PhoD-like phosphatase; Region: PhoD; pfam09423 692420000771 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 692420000772 putative active site [active] 692420000773 putative metal binding site [ion binding]; other site 692420000774 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 692420000775 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 692420000776 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 692420000777 putative substrate binding pocket [chemical binding]; other site 692420000778 AC domain interface; other site 692420000779 catalytic triad [active] 692420000780 AB domain interface; other site 692420000781 interchain disulfide; other site 692420000782 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420000783 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420000784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420000785 catalytic residue [active] 692420000786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420000788 putative substrate translocation pore; other site 692420000789 potential frameshift: common BLAST hit: gi|154684770|ref|YP_001419931.1| Lip 692420000790 potential frameshift: common BLAST hit: gi|154684770|ref|YP_001419931.1| Lip; similar to lipase fragment 692420000791 similar to lipase fragment 692420000792 similar to lipase fragment 692420000793 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 692420000794 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 692420000795 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 692420000796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420000797 active site 692420000798 catalytic tetrad [active] 692420000799 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 692420000800 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 692420000801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420000802 binding surface 692420000803 TPR motif; other site 692420000804 glucose-1-dehydrogenase; Provisional; Region: PRK08936 692420000805 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 692420000806 NAD binding site [chemical binding]; other site 692420000807 homodimer interface [polypeptide binding]; other site 692420000808 active site 692420000809 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420000810 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420000811 Ca binding site [ion binding]; other site 692420000812 active site 692420000813 catalytic site [active] 692420000814 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420000815 Helix-turn-helix domains; Region: HTH; cl00088 692420000816 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 692420000817 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 692420000818 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 692420000819 metal binding site [ion binding]; metal-binding site 692420000820 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 692420000821 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 692420000822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000823 ABC-ATPase subunit interface; other site 692420000824 dimer interface [polypeptide binding]; other site 692420000825 putative PBP binding regions; other site 692420000826 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 692420000827 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420000828 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000829 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000830 putative metal binding site [ion binding]; other site 692420000831 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000832 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000833 putative metal binding site [ion binding]; other site 692420000834 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000835 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000836 putative metal binding site [ion binding]; other site 692420000837 Integral membrane protein TerC family; Region: TerC; cl10468 692420000838 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 692420000839 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 692420000840 benzoate transport; Region: 2A0115; TIGR00895 692420000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000842 putative substrate translocation pore; other site 692420000843 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 692420000844 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 692420000845 Walker A/P-loop; other site 692420000846 ATP binding site [chemical binding]; other site 692420000847 Q-loop/lid; other site 692420000848 ABC transporter signature motif; other site 692420000849 Walker B; other site 692420000850 D-loop; other site 692420000851 H-loop/switch region; other site 692420000852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 692420000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420000854 dimer interface [polypeptide binding]; other site 692420000855 conserved gate region; other site 692420000856 putative PBP binding loops; other site 692420000857 ABC-ATPase subunit interface; other site 692420000858 NMT1-like family; Region: NMT1_2; cl15260 692420000859 NMT1-like family; Region: NMT1_2; cl15260 692420000860 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 692420000861 amidohydrolase; Region: amidohydrolases; TIGR01891 692420000862 metal binding site [ion binding]; metal-binding site 692420000863 putative dimer interface [polypeptide binding]; other site 692420000864 potential frameshift: common BLAST hit: gi|154684795|ref|YP_001419956.1| YcgA 692420000865 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420000866 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420000867 RDD family; Region: RDD; cl00746 692420000868 RDD family; Region: RDD; cl00746 692420000869 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 692420000870 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 692420000871 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420000872 NAD binding site [chemical binding]; other site 692420000873 dimer interface [polypeptide binding]; other site 692420000874 substrate binding site [chemical binding]; other site 692420000875 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420000876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000877 putative substrate translocation pore; other site 692420000878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000879 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420000880 Helix-turn-helix domains; Region: HTH; cl00088 692420000881 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420000882 DNA binding residues [nucleotide binding] 692420000883 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 692420000884 potential frameshift: common BLAST hit: gi|154684801|ref|YP_001419962.1| YcgF 692420000885 similar to amino acid efflux protein ycgF fragment; amino acid efflux protein ycgF;, Lysine exporter protein (LYSE/YGGA) 692420000886 similar to amino acid efflux protein ycgF fragment; amino acid efflux protein ycgF;, Lysine exporter protein (LYSE/YGGA) 692420000887 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 692420000888 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420000889 Spore germination protein; Region: Spore_permease; cl15802 692420000890 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 692420000891 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 692420000892 NAD+ synthetase; Region: nadE; TIGR00552 692420000893 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 692420000894 homodimer interface [polypeptide binding]; other site 692420000895 NAD binding pocket [chemical binding]; other site 692420000896 ATP binding pocket [chemical binding]; other site 692420000897 Mg binding site [ion binding]; other site 692420000898 active-site loop [active] 692420000899 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 692420000900 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 692420000901 similar to galactarate/glucarate transporter in (proton symport); Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8;, Major facilitator superfamily MFS-1 692420000902 similar to galactarate/glucarate transporter in (proton symport) fragment; glucarate transporter; D-glucarate permease;, Major facilitator superfamily MFS-1 692420000903 shikimate kinase; Reviewed; Region: aroK; PRK00131 692420000904 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 692420000905 ADP binding site [chemical binding]; other site 692420000906 magnesium binding site [ion binding]; other site 692420000907 putative shikimate binding site; other site 692420000908 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 692420000909 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 692420000910 Proline dehydrogenase; Region: Pro_dh; cl03282 692420000911 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 692420000912 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 692420000913 Glutamate binding site [chemical binding]; other site 692420000914 homodimer interface [polypeptide binding]; other site 692420000915 NAD binding site [chemical binding]; other site 692420000916 catalytic residues [active] 692420000917 Sodium:solute symporter family; Region: SSF; cl00456 692420000918 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420000919 Helix-turn-helix domains; Region: HTH; cl00088 692420000920 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 692420000921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420000922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420000923 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 692420000924 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 692420000925 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 692420000926 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420000927 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 692420000928 [2Fe-2S] cluster binding site [ion binding]; other site 692420000929 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 692420000930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420000931 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 692420000932 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 692420000933 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420000934 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 692420000935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420000936 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 692420000937 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 692420000938 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420000939 NAD binding site [chemical binding]; other site 692420000940 catalytic Zn binding site [ion binding]; other site 692420000941 structural Zn binding site [ion binding]; other site 692420000942 RDD family; Region: RDD; cl00746 692420000943 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 692420000944 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420000945 Competence protein J (ComJ); Region: ComJ; pfam11033 692420000946 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 692420000947 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 692420000948 tetramer interface [polypeptide binding]; other site 692420000949 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 692420000950 active site 692420000951 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 692420000952 active site 692420000953 dimer interface [polypeptide binding]; other site 692420000954 magnesium binding site [ion binding]; other site 692420000955 Helix-turn-helix domains; Region: HTH; cl00088 692420000956 peptide synthase; Provisional; Region: PRK12316 692420000957 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420000958 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000959 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000960 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000961 peptide synthase; Provisional; Region: PRK12316 692420000962 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420000963 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000964 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000965 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000966 peptide synthase; Provisional; Region: PRK12316 692420000967 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420000968 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000970 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420000971 peptide synthase; Provisional; Region: PRK12467 692420000972 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000973 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000974 peptide synthase; Provisional; Region: PRK12467 692420000975 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420000976 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000977 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420000979 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000980 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000981 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420000982 peptide synthase; Provisional; Region: PRK12467 692420000983 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000984 AMP-binding enzyme; Region: AMP-binding; cl15778 692420000985 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420000986 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 692420000987 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 692420000988 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 692420000989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420000990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000991 homodimer interface [polypeptide binding]; other site 692420000992 catalytic residue [active] 692420000993 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 692420000994 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 692420000995 Predicted membrane protein [Function unknown]; Region: COG2364 692420000996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420000997 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420000998 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 692420000999 Walker A/P-loop; other site 692420001000 ATP binding site [chemical binding]; other site 692420001001 Q-loop/lid; other site 692420001002 ABC transporter signature motif; other site 692420001003 Walker B; other site 692420001004 D-loop; other site 692420001005 H-loop/switch region; other site 692420001006 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420001007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420001008 dimer interface [polypeptide binding]; other site 692420001009 conserved gate region; other site 692420001010 putative PBP binding loops; other site 692420001011 ABC-ATPase subunit interface; other site 692420001012 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 692420001013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420001014 substrate binding pocket [chemical binding]; other site 692420001015 membrane-bound complex binding site; other site 692420001016 hinge residues; other site 692420001017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420001018 Helix-turn-helix domains; Region: HTH; cl00088 692420001019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420001020 dimerization interface [polypeptide binding]; other site 692420001021 aromatic acid decarboxylase; Validated; Region: PRK05920 692420001022 Flavoprotein; Region: Flavoprotein; cl08021 692420001023 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 692420001024 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 692420001025 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 692420001026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001027 putative substrate translocation pore; other site 692420001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 692420001029 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420001030 Right handed beta helix region; Region: Beta_helix; pfam13229 692420001031 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 692420001032 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420001033 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 692420001034 Spore germination protein; Region: Spore_permease; cl15802 692420001035 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 692420001036 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 692420001037 active site 692420001038 non-prolyl cis peptide bond; other site 692420001039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420001041 Coenzyme A binding pocket [chemical binding]; other site 692420001042 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420001043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420001044 substrate binding pocket [chemical binding]; other site 692420001045 membrane-bound complex binding site; other site 692420001046 hinge residues; other site 692420001047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420001048 dimer interface [polypeptide binding]; other site 692420001049 conserved gate region; other site 692420001050 putative PBP binding loops; other site 692420001051 ABC-ATPase subunit interface; other site 692420001052 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420001053 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 692420001054 Walker A/P-loop; other site 692420001055 ATP binding site [chemical binding]; other site 692420001056 Q-loop/lid; other site 692420001057 ABC transporter signature motif; other site 692420001058 Walker B; other site 692420001059 D-loop; other site 692420001060 H-loop/switch region; other site 692420001061 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420001062 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 692420001063 metal binding site [ion binding]; metal-binding site 692420001064 dimer interface [polypeptide binding]; other site 692420001065 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 692420001066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420001067 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 692420001068 Walker A/P-loop; other site 692420001069 ATP binding site [chemical binding]; other site 692420001070 Q-loop/lid; other site 692420001071 ABC transporter signature motif; other site 692420001072 Walker B; other site 692420001073 D-loop; other site 692420001074 H-loop/switch region; other site 692420001075 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420001076 FtsX-like permease family; Region: FtsX; cl15850 692420001077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420001078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420001079 active site 692420001080 phosphorylation site [posttranslational modification] 692420001081 intermolecular recognition site; other site 692420001082 dimerization interface [polypeptide binding]; other site 692420001083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420001084 DNA binding site [nucleotide binding] 692420001085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420001086 dimerization interface [polypeptide binding]; other site 692420001087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420001088 dimer interface [polypeptide binding]; other site 692420001089 phosphorylation site [posttranslational modification] 692420001090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001091 ATP binding site [chemical binding]; other site 692420001092 Mg2+ binding site [ion binding]; other site 692420001093 G-X-G motif; other site 692420001094 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420001097 TPR motif; other site 692420001098 binding surface 692420001099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001100 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 692420001101 aspartate kinase; Reviewed; Region: PRK09034 692420001102 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 692420001103 putative catalytic residues [active] 692420001104 putative nucleotide binding site [chemical binding]; other site 692420001105 putative aspartate binding site [chemical binding]; other site 692420001106 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 692420001107 allosteric regulatory residue; other site 692420001108 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 692420001109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420001110 ABC-ATPase subunit interface; other site 692420001111 dimer interface [polypeptide binding]; other site 692420001112 putative PBP binding regions; other site 692420001113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420001114 ABC-ATPase subunit interface; other site 692420001115 dimer interface [polypeptide binding]; other site 692420001116 putative PBP binding regions; other site 692420001117 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 692420001118 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420001119 Walker A/P-loop; other site 692420001120 ATP binding site [chemical binding]; other site 692420001121 Q-loop/lid; other site 692420001122 ABC transporter signature motif; other site 692420001123 Walker B; other site 692420001124 D-loop; other site 692420001125 H-loop/switch region; other site 692420001126 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 692420001127 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 692420001128 putative ligand binding residues [chemical binding]; other site 692420001129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420001131 putative substrate translocation pore; other site 692420001132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001134 Helix-turn-helix domains; Region: HTH; cl00088 692420001135 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 692420001136 dimer interface [polypeptide binding]; other site 692420001137 FMN binding site [chemical binding]; other site 692420001138 NADPH bind site [chemical binding]; other site 692420001139 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420001140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420001141 dimerization interface [polypeptide binding]; other site 692420001142 putative DNA binding site [nucleotide binding]; other site 692420001143 putative Zn2+ binding site [ion binding]; other site 692420001144 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001146 DNA-binding site [nucleotide binding]; DNA binding site 692420001147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001149 homodimer interface [polypeptide binding]; other site 692420001150 catalytic residue [active] 692420001151 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 692420001152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420001153 inhibitor-cofactor binding pocket; inhibition site 692420001154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001155 catalytic residue [active] 692420001156 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 692420001157 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420001158 tetramerization interface [polypeptide binding]; other site 692420001159 NAD(P) binding site [chemical binding]; other site 692420001160 catalytic residues [active] 692420001161 Sugar transport protein; Region: Sugar_transport; pfam06800 692420001162 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 692420001163 glucose-1-dehydrogenase; Provisional; Region: PRK08936 692420001164 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 692420001165 NAD binding site [chemical binding]; other site 692420001166 homodimer interface [polypeptide binding]; other site 692420001167 active site 692420001168 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 692420001169 Bacterial Ig-like domain; Region: Big_5; cl01012 692420001170 Copper resistance protein D; Region: CopD; cl00563 692420001171 FixH; Region: FixH; cl01254 692420001172 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420001173 Helix-turn-helix domains; Region: HTH; cl00088 692420001174 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 692420001175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420001176 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 692420001177 active site 692420001178 P-loop; other site 692420001179 phosphorylation site [posttranslational modification] 692420001180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420001181 active site 692420001182 phosphorylation site [posttranslational modification] 692420001183 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 692420001184 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 692420001185 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 692420001186 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 692420001187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420001188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420001189 active site 692420001190 motif I; other site 692420001191 motif II; other site 692420001192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420001193 LamB/YcsF family; Region: LamB_YcsF; cl00664 692420001194 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 692420001195 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 692420001196 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 692420001197 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 692420001198 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 692420001199 Transcriptional regulator [Transcription]; Region: IclR; COG1414 692420001200 Helix-turn-helix domains; Region: HTH; cl00088 692420001201 Bacterial transcriptional regulator; Region: IclR; pfam01614 692420001202 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 692420001203 active site 692420001204 catalytic triad [active] 692420001205 oxyanion hole [active] 692420001206 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 692420001207 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420001208 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 692420001209 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 692420001210 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420001211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420001212 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420001213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420001214 active site 692420001215 catalytic tetrad [active] 692420001216 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420001217 Helix-turn-helix domains; Region: HTH; cl00088 692420001218 Helix-turn-helix domains; Region: HTH; cl00088 692420001219 PRD domain; Region: PRD; cl15445 692420001220 PRD domain; Region: PRD; cl15445 692420001221 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420001222 P-loop; other site 692420001223 active site 692420001224 phosphorylation site [posttranslational modification] 692420001225 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 692420001226 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 692420001227 AMP-binding enzyme; Region: AMP-binding; cl15778 692420001228 AMP-binding enzyme; Region: AMP-binding; cl15778 692420001229 short chain dehydrogenase; Provisional; Region: PRK06701 692420001230 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 692420001231 NAD binding site [chemical binding]; other site 692420001232 metal binding site [ion binding]; metal-binding site 692420001233 active site 692420001234 Cupin domain; Region: Cupin_2; cl09118 692420001235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 692420001236 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420001237 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 692420001238 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 692420001239 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 692420001240 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 692420001241 Helix-turn-helix domains; Region: HTH; cl00088 692420001242 DNA topoisomerase III; Provisional; Region: PRK07726 692420001243 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 692420001244 active site 692420001245 putative interdomain interaction site [polypeptide binding]; other site 692420001246 putative metal-binding site [ion binding]; other site 692420001247 putative nucleotide binding site [chemical binding]; other site 692420001248 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 692420001249 domain I; other site 692420001250 DNA binding groove [nucleotide binding] 692420001251 phosphate binding site [ion binding]; other site 692420001252 domain II; other site 692420001253 domain III; other site 692420001254 nucleotide binding site [chemical binding]; other site 692420001255 catalytic site [active] 692420001256 domain IV; other site 692420001257 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 692420001258 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 692420001259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420001260 metal binding site [ion binding]; metal-binding site 692420001261 active site 692420001262 I-site; other site 692420001263 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 692420001264 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 692420001265 NodB motif; other site 692420001266 putative active site [active] 692420001267 putative catalytic site [active] 692420001268 putative Zn binding site [ion binding]; other site 692420001269 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 692420001270 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 692420001271 DXD motif; other site 692420001272 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 692420001273 Amino acid permease; Region: AA_permease_2; pfam13520 692420001274 pyruvate oxidase; Provisional; Region: PRK08611 692420001275 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 692420001276 PYR/PP interface [polypeptide binding]; other site 692420001277 tetramer interface [polypeptide binding]; other site 692420001278 dimer interface [polypeptide binding]; other site 692420001279 TPP binding site [chemical binding]; other site 692420001280 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 692420001281 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 692420001282 TPP-binding site [chemical binding]; other site 692420001283 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001285 Coenzyme A binding pocket [chemical binding]; other site 692420001286 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420001287 putative peptidoglycan binding site; other site 692420001288 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 692420001289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001291 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420001292 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 692420001293 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 692420001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 692420001295 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420001296 EcsC protein family; Region: EcsC; pfam12787 692420001297 General stress protein [General function prediction only]; Region: GsiB; COG3729 692420001298 Cupin domain; Region: Cupin_2; cl09118 692420001299 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420001300 dimanganese center [ion binding]; other site 692420001301 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 692420001302 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420001303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420001304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001305 ATP binding site [chemical binding]; other site 692420001306 Mg2+ binding site [ion binding]; other site 692420001307 G-X-G motif; other site 692420001308 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420001309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420001310 active site 692420001311 phosphorylation site [posttranslational modification] 692420001312 intermolecular recognition site; other site 692420001313 dimerization interface [polypeptide binding]; other site 692420001314 Helix-turn-helix domains; Region: HTH; cl00088 692420001315 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420001316 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420001317 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420001318 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 692420001319 Walker A/P-loop; other site 692420001320 ATP binding site [chemical binding]; other site 692420001321 Q-loop/lid; other site 692420001322 ABC transporter signature motif; other site 692420001323 Walker B; other site 692420001324 D-loop; other site 692420001325 H-loop/switch region; other site 692420001326 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420001327 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420001328 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420001329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 692420001330 active site 692420001331 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420001332 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 692420001333 Cation efflux family; Region: Cation_efflux; cl00316 692420001334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420001335 catalytic residues [active] 692420001336 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 692420001337 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 692420001338 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420001339 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420001340 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 692420001341 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420001342 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420001343 helicase 45; Provisional; Region: PTZ00424 692420001344 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420001345 ATP binding site [chemical binding]; other site 692420001346 Mg++ binding site [ion binding]; other site 692420001347 motif III; other site 692420001348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420001349 nucleotide binding region [chemical binding]; other site 692420001350 ATP-binding site [chemical binding]; other site 692420001351 Bacterial PH domain; Region: DUF304; cl01348 692420001352 Predicted membrane protein [Function unknown]; Region: COG3428 692420001353 Bacterial PH domain; Region: DUF304; cl01348 692420001354 Bacterial PH domain; Region: DUF304; cl01348 692420001355 Bacterial PH domain; Region: DUF304; cl01348 692420001356 Rhomboid family; Region: Rhomboid; cl11446 692420001357 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 692420001358 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 692420001359 alanine racemase; Region: alr; TIGR00492 692420001360 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 692420001361 active site 692420001362 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420001363 dimer interface [polypeptide binding]; other site 692420001364 substrate binding site [chemical binding]; other site 692420001365 catalytic residues [active] 692420001366 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 692420001367 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 692420001368 PemK-like protein; Region: PemK; cl00995 692420001369 Rsbr N terminal; Region: Rsbr_N; pfam08678 692420001370 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420001371 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420001372 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420001373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001374 ATP binding site [chemical binding]; other site 692420001375 Mg2+ binding site [ion binding]; other site 692420001376 G-X-G motif; other site 692420001377 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 692420001378 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 692420001379 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 692420001380 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 692420001381 anti sigma factor interaction site; other site 692420001382 regulatory phosphorylation site [posttranslational modification]; other site 692420001383 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420001384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001385 ATP binding site [chemical binding]; other site 692420001386 Mg2+ binding site [ion binding]; other site 692420001387 G-X-G motif; other site 692420001388 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 692420001389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001390 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420001391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001392 DNA binding residues [nucleotide binding] 692420001393 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 692420001394 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 692420001395 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 692420001396 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 692420001397 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 692420001398 RNA binding site [nucleotide binding]; other site 692420001399 SprT homologues; Region: SprT; cl01182 692420001400 hypothetical protein; Provisional; Region: PRK04351 692420001401 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420001402 Helix-turn-helix domains; Region: HTH; cl00088 692420001403 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420001404 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 692420001405 DNA-binding site [nucleotide binding]; DNA binding site 692420001406 RNA-binding motif; other site 692420001407 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 692420001408 aspartate racemase; Region: asp_race; TIGR00035 692420001409 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 692420001410 Helix-turn-helix domains; Region: HTH; cl00088 692420001411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001413 DNA-binding site [nucleotide binding]; DNA binding site 692420001414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001416 homodimer interface [polypeptide binding]; other site 692420001417 catalytic residue [active] 692420001418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001419 putative substrate translocation pore; other site 692420001420 potential frameshift: common BLAST hit: gi|16080506|ref|NP_391333.1| spore coat protein assembly factor CotR 692420001421 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 692420001422 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 692420001423 active site 692420001424 nucleophile elbow; other site 692420001425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420001426 FAD binding domain; Region: FAD_binding_4; pfam01565 692420001427 Berberine and berberine like; Region: BBE; pfam08031 692420001428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420001429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 692420001430 Cation efflux family; Region: Cation_efflux; cl00316 692420001431 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420001432 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420001433 Cupin domain; Region: Cupin_2; cl09118 692420001434 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420001435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001436 Coenzyme A binding pocket [chemical binding]; other site 692420001437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420001438 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420001439 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 692420001440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420001441 FeS/SAM binding site; other site 692420001442 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 692420001443 Membrane transport protein; Region: Mem_trans; cl09117 692420001444 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 692420001445 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 692420001446 putative NAD(P) binding site [chemical binding]; other site 692420001447 putative substrate binding site [chemical binding]; other site 692420001448 catalytic Zn binding site [ion binding]; other site 692420001449 structural Zn binding site [ion binding]; other site 692420001450 dimer interface [polypeptide binding]; other site 692420001451 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420001452 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 692420001453 DNA binding residues [nucleotide binding] 692420001454 putative dimer interface [polypeptide binding]; other site 692420001455 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 692420001456 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001458 DNA-binding site [nucleotide binding]; DNA binding site 692420001459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001461 homodimer interface [polypeptide binding]; other site 692420001462 catalytic residue [active] 692420001463 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 692420001464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001466 Helix-turn-helix domains; Region: HTH; cl00088 692420001467 EamA-like transporter family; Region: EamA; cl01037 692420001468 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 692420001469 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001471 DNA-binding site [nucleotide binding]; DNA binding site 692420001472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001474 homodimer interface [polypeptide binding]; other site 692420001475 catalytic residue [active] 692420001476 Coat F domain; Region: Coat_F; cl15836 692420001477 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 692420001478 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420001479 NAD binding site [chemical binding]; other site 692420001480 catalytic Zn binding site [ion binding]; other site 692420001481 structural Zn binding site [ion binding]; other site 692420001482 Coat F domain; Region: Coat_F; cl15836 692420001483 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 692420001484 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 692420001485 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 692420001486 catalytic triad [active] 692420001487 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001488 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001489 ABC transporter; Region: ABC_tran_2; pfam12848 692420001490 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420001492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001493 Coenzyme A binding pocket [chemical binding]; other site 692420001494 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420001495 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420001496 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420001497 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420001498 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 692420001499 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 692420001500 dimer interface [polypeptide binding]; other site 692420001501 active site 692420001502 metal binding site [ion binding]; metal-binding site 692420001503 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 692420001504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001505 putative substrate translocation pore; other site 692420001506 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 692420001507 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420001508 dimer interface [polypeptide binding]; other site 692420001509 active site 692420001510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420001511 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 692420001512 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420001513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001514 Coenzyme A binding pocket [chemical binding]; other site 692420001515 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 692420001516 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420001517 DNA binding residues [nucleotide binding] 692420001518 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420001519 EamA-like transporter family; Region: EamA; cl01037 692420001520 EamA-like transporter family; Region: EamA; cl01037 692420001521 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 692420001522 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 692420001523 nudix motif; other site 692420001524 Epoxide hydrolase N terminus; Region: EHN; pfam06441 692420001525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420001526 tartrate dehydrogenase; Provisional; Region: PRK08194 692420001527 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 692420001528 Transcriptional regulators [Transcription]; Region: GntR; COG1802 692420001529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001530 DNA-binding site [nucleotide binding]; DNA binding site 692420001531 FCD domain; Region: FCD; cl11656 692420001532 potential frameshift: common BLAST hit: gi|154685073|ref|YP_001420234.1| YdhE 692420001533 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420001534 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420001535 active site 692420001536 TDP-binding site; other site 692420001537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420001538 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 692420001539 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 692420001540 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 692420001541 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001543 putative substrate translocation pore; other site 692420001544 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420001545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001546 DNA-binding site [nucleotide binding]; DNA binding site 692420001547 UTRA domain; Region: UTRA; cl01230 692420001548 Transcriptional regulators [Transcription]; Region: FadR; COG2186 692420001549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001550 DNA-binding site [nucleotide binding]; DNA binding site 692420001551 FCD domain; Region: FCD; cl11656 692420001552 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 692420001553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001554 putative substrate translocation pore; other site 692420001555 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420001556 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420001557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001558 Helix-turn-helix domains; Region: HTH; cl00088 692420001559 amino acid transporter; Region: 2A0306; TIGR00909 692420001560 Spore germination protein; Region: Spore_permease; cl15802 692420001561 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420001562 dimanganese center [ion binding]; other site 692420001563 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 692420001564 putative hydrophobic ligand binding site [chemical binding]; other site 692420001565 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 692420001566 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 692420001567 putative NADP binding site [chemical binding]; other site 692420001568 putative dimer interface [polypeptide binding]; other site 692420001569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001570 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420001571 putative substrate translocation pore; other site 692420001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001573 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 692420001574 ATP binding site [chemical binding]; other site 692420001575 dimerization interface [polypeptide binding]; other site 692420001576 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 692420001577 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 692420001578 Glycoprotease family; Region: Peptidase_M22; pfam00814 692420001579 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 692420001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001581 Coenzyme A binding pocket [chemical binding]; other site 692420001582 UGMP family protein; Validated; Region: PRK09604 692420001583 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 692420001584 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001585 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001586 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001587 ABC transporter; Region: ABC_tran_2; pfam12848 692420001588 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001589 ABC transporter; Region: ABC_tran_2; pfam12848 692420001590 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 692420001591 trimer interface [polypeptide binding]; other site 692420001592 dimer interface [polypeptide binding]; other site 692420001593 putative active site [active] 692420001594 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 692420001595 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 692420001596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420001597 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 692420001598 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 692420001599 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 692420001600 CAAX protease self-immunity; Region: Abi; cl00558 692420001601 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 692420001602 oligomerisation interface [polypeptide binding]; other site 692420001603 mobile loop; other site 692420001604 roof hairpin; other site 692420001605 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 692420001606 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 692420001607 ring oligomerisation interface [polypeptide binding]; other site 692420001608 ATP/Mg binding site [chemical binding]; other site 692420001609 stacking interactions; other site 692420001610 hinge regions; other site 692420001611 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 692420001612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420001613 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420001614 Int/Topo IB signature motif; other site 692420001615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420001616 non-specific DNA binding site [nucleotide binding]; other site 692420001617 salt bridge; other site 692420001618 sequence-specific DNA binding site [nucleotide binding]; other site 692420001619 BRO family, N-terminal domain; Region: Bro-N; cl10591 692420001620 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 692420001621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420001622 Hypothetical protein Yqai; Region: Yqai; pfam09466 692420001623 potential frameshift: common BLAST hit: gi|16079682|ref|NP_390506.1| nuclease; skin element 692420001624 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 692420001625 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 692420001626 RecT family; Region: RecT; cl04285 692420001627 Helix-turn-helix domains; Region: HTH; cl00088 692420001628 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 692420001629 hypothetical protein; Provisional; Region: PRK06921 692420001630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001631 Walker A motif; other site 692420001632 ATP binding site [chemical binding]; other site 692420001633 Walker B motif; other site 692420001634 arginine finger; other site 692420001635 YopX protein; Region: YopX; cl09859 692420001636 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 692420001637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420001638 cofactor binding site; other site 692420001639 DNA binding site [nucleotide binding] 692420001640 substrate interaction site [chemical binding]; other site 692420001641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420001642 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 692420001643 dUTPase; Region: dUTPase_2; pfam08761 692420001644 YopX protein; Region: YopX; cl09859 692420001645 positive control sigma-like factor; Validated; Region: PRK06930 692420001646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001647 DNA binding residues [nucleotide binding] 692420001648 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420001649 Uncharacterized conserved protein [Function unknown]; Region: COG5484 692420001650 Helix-turn-helix domains; Region: HTH; cl00088 692420001651 Phage terminase large subunit; Region: Terminase_3; cl12054 692420001652 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 692420001653 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 692420001654 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 692420001655 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 692420001656 transcription termination factor Rho; Provisional; Region: rho; PRK09376 692420001657 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 692420001658 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 692420001659 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 692420001660 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 692420001661 Phage major tail protein 2; Region: Phage_tail_2; cl11463 692420001662 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 692420001663 Interdomain contacts; other site 692420001664 Cytokine receptor motif; other site 692420001665 Phage protein; Region: DUF3647; cl10335 692420001666 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 692420001667 Phage-related protein [Function unknown]; Region: COG5412 692420001668 Phage-related protein [Function unknown]; Region: COG4722; cl15832 692420001669 Phage tail protein; Region: Sipho_tail; pfam05709 692420001670 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420001671 Haemolysin XhlA; Region: XhlA; pfam10779 692420001672 Phage lysis protein, holin; Region: Phage_holin; cl04675 692420001673 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420001674 amidase catalytic site [active] 692420001675 Zn binding residues [ion binding]; other site 692420001676 substrate binding site [chemical binding]; other site 692420001677 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420001678 putative peptidoglycan binding site; other site 692420001679 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420001680 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420001681 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420001682 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420001683 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 692420001684 active site 692420001685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001686 Walker A motif; other site 692420001687 ATP binding site [chemical binding]; other site 692420001688 Walker B motif; other site 692420001689 Tetratricopeptide repeat; Region: TPR_16; pfam13432 692420001690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420001691 binding surface 692420001692 TPR motif; other site 692420001693 TPR repeat; Region: TPR_11; pfam13414 692420001694 L-idonate 5-dehydrogenase; Region: PLN02702 692420001695 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 692420001696 inhibitor binding site; inhibition site 692420001697 catalytic Zn binding site [ion binding]; other site 692420001698 structural Zn binding site [ion binding]; other site 692420001699 NADP binding site [chemical binding]; other site 692420001700 tetramer interface [polypeptide binding]; other site 692420001701 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 692420001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001703 putative substrate translocation pore; other site 692420001704 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420001705 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 692420001706 putative substrate binding site [chemical binding]; other site 692420001707 putative ATP binding site [chemical binding]; other site 692420001708 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 692420001709 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 692420001710 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 692420001711 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 692420001712 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 692420001713 Repair protein; Region: Repair_PSII; cl01535 692420001714 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 692420001715 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 692420001716 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 692420001717 OpgC protein; Region: OpgC_C; cl00792 692420001718 Acyltransferase family; Region: Acyl_transf_3; pfam01757 692420001719 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 692420001720 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 692420001721 catalytic triad [active] 692420001722 catalytic triad [active] 692420001723 oxyanion hole [active] 692420001724 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 692420001725 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 692420001726 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 692420001727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001728 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001729 DNA binding residues [nucleotide binding] 692420001730 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420001731 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 692420001732 putative NAD(P) binding site [chemical binding]; other site 692420001733 catalytic Zn binding site [ion binding]; other site 692420001734 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 692420001735 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 692420001736 Cold-inducible protein YdjO; Region: YdjO; pfam14169 692420001737 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 692420001738 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 692420001739 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 692420001740 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 692420001741 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 692420001742 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420001743 Cation efflux family; Region: Cation_efflux; cl00316 692420001744 MoxR-like ATPases [General function prediction only]; Region: COG0714 692420001745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001746 Walker A motif; other site 692420001747 ATP binding site [chemical binding]; other site 692420001748 Walker B motif; other site 692420001749 arginine finger; other site 692420001750 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 692420001751 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 692420001752 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 692420001753 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 692420001754 GMP synthase; Reviewed; Region: guaA; PRK00074 692420001755 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 692420001756 AMP/PPi binding site [chemical binding]; other site 692420001757 candidate oxyanion hole; other site 692420001758 catalytic triad [active] 692420001759 potential glutamine specificity residues [chemical binding]; other site 692420001760 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 692420001761 ATP Binding subdomain [chemical binding]; other site 692420001762 Ligand Binding sites [chemical binding]; other site 692420001763 Dimerization subdomain; other site 692420001764 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 692420001765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001767 DNA binding residues [nucleotide binding] 692420001768 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 692420001769 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 692420001770 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 692420001771 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420001772 NETI protein; Region: NETI; pfam14044 692420001773 AIR carboxylase; Region: AIRC; cl00310 692420001774 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 692420001775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420001776 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420001777 adenylosuccinate lyase; Provisional; Region: PRK07492 692420001778 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 692420001779 tetramer interface [polypeptide binding]; other site 692420001780 active site 692420001781 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 692420001782 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 692420001783 ATP binding site [chemical binding]; other site 692420001784 active site 692420001785 substrate binding site [chemical binding]; other site 692420001786 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 692420001787 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 692420001788 putative active site [active] 692420001789 catalytic triad [active] 692420001790 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 692420001791 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 692420001792 dimerization interface [polypeptide binding]; other site 692420001793 ATP binding site [chemical binding]; other site 692420001794 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 692420001795 dimerization interface [polypeptide binding]; other site 692420001796 ATP binding site [chemical binding]; other site 692420001797 amidophosphoribosyltransferase; Provisional; Region: PRK07631 692420001798 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 692420001799 active site 692420001800 tetramer interface [polypeptide binding]; other site 692420001801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420001802 active site 692420001803 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 692420001804 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 692420001805 dimerization interface [polypeptide binding]; other site 692420001806 putative ATP binding site [chemical binding]; other site 692420001807 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 692420001808 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 692420001809 active site 692420001810 substrate binding site [chemical binding]; other site 692420001811 cosubstrate binding site; other site 692420001812 catalytic site [active] 692420001813 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 692420001814 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 692420001815 purine monophosphate binding site [chemical binding]; other site 692420001816 dimer interface [polypeptide binding]; other site 692420001817 putative catalytic residues [active] 692420001818 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 692420001819 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 692420001820 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 692420001821 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 692420001822 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420001823 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 692420001824 Helix-turn-helix domains; Region: HTH; cl00088 692420001825 putative transporter; Provisional; Region: PRK11021 692420001826 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 692420001827 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 692420001828 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420001829 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 692420001830 active site 692420001831 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420001832 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 692420001833 Helix-turn-helix domains; Region: HTH; cl00088 692420001834 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 692420001835 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 692420001836 active site 692420001837 FMN binding site [chemical binding]; other site 692420001838 substrate binding site [chemical binding]; other site 692420001839 3Fe-4S cluster binding site [ion binding]; other site 692420001840 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 692420001841 substrate binding site [chemical binding]; other site 692420001842 putative active site [active] 692420001843 dimer interface [polypeptide binding]; other site 692420001844 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 692420001845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420001846 Family description; Region: UvrD_C_2; cl15862 692420001847 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 692420001848 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 692420001849 nucleotide binding pocket [chemical binding]; other site 692420001850 K-X-D-G motif; other site 692420001851 catalytic site [active] 692420001852 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 692420001853 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 692420001854 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 692420001855 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 692420001856 Dimer interface [polypeptide binding]; other site 692420001857 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 692420001858 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420001859 active site 692420001860 ATP binding site [chemical binding]; other site 692420001861 substrate binding site [chemical binding]; other site 692420001862 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 692420001863 MgtC family; Region: MgtC; pfam02308 692420001864 Sodium:solute symporter family; Region: SSF; cl00456 692420001865 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 692420001866 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 692420001867 Amidase; Region: Amidase; cl11426 692420001868 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 692420001869 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 692420001870 GatB domain; Region: GatB_Yqey; cl11497 692420001871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001872 Helix-turn-helix domains; Region: HTH; cl00088 692420001873 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 692420001874 Protein export membrane protein; Region: SecD_SecF; cl14618 692420001875 putative lipid kinase; Reviewed; Region: PRK13337 692420001876 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 692420001877 TRAM domain; Region: TRAM; cl01282 692420001878 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 692420001879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420001880 S-adenosylmethionine binding site [chemical binding]; other site 692420001881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420001882 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 692420001883 Uncharacterized conserved protein [Function unknown]; Region: COG3410 692420001884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420001885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420001886 Walker A/P-loop; other site 692420001887 ATP binding site [chemical binding]; other site 692420001888 Q-loop/lid; other site 692420001889 ABC transporter signature motif; other site 692420001890 Walker B; other site 692420001891 D-loop; other site 692420001892 H-loop/switch region; other site 692420001893 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 692420001894 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 692420001895 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420001896 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420001897 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420001898 similar to DNA binding protein YeeF fragment; UPF0720 protein yeeF 692420001899 Uncharacterized conserved protein [Function unknown]; Region: COG5444 692420001900 Transcriptional regulator; Region: Transcrip_reg; cl00361 692420001901 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 692420001902 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 692420001903 CotJB protein; Region: CotJB; pfam12652 692420001904 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420001905 dimanganese center [ion binding]; other site 692420001906 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420001907 YesK-like protein; Region: YesK; pfam14150 692420001908 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420001909 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420001910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420001911 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 692420001912 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420001913 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 692420001914 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 692420001915 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420001916 Helix-turn-helix domains; Region: HTH; cl00088 692420001917 hypothetical protein; Provisional; Region: PRK06847 692420001918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420001919 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 692420001920 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 692420001921 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420001922 Cytochrome P450; Region: p450; pfam00067 692420001923 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 692420001924 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420001925 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 692420001926 FAD binding pocket [chemical binding]; other site 692420001927 FAD binding motif [chemical binding]; other site 692420001928 catalytic residues [active] 692420001929 NAD binding pocket [chemical binding]; other site 692420001930 phosphate binding motif [ion binding]; other site 692420001931 beta-alpha-beta structure motif; other site 692420001932 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420001933 Sulfatase; Region: Sulfatase; cl10460 692420001934 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 692420001935 substrate binding site; other site 692420001936 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 692420001937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420001938 NAD(P) binding site [chemical binding]; other site 692420001939 active site 692420001940 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 692420001941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420001942 active site 692420001943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 692420001944 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 692420001945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420001947 putative substrate translocation pore; other site 692420001948 Spore germination protein; Region: Spore_permease; cl15802 692420001949 amino acid transporter; Region: 2A0306; TIGR00909 692420001950 Spore germination protein; Region: Spore_permease; cl15802 692420001951 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 692420001952 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420001953 NAD(P) binding site [chemical binding]; other site 692420001954 catalytic residues [active] 692420001955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420001956 dimer interface [polypeptide binding]; other site 692420001957 putative CheW interface [polypeptide binding]; other site 692420001958 oxidoreductase; Provisional; Region: PRK07985 692420001959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420001960 NAD(P) binding site [chemical binding]; other site 692420001961 active site 692420001962 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 692420001963 putative metal binding site; other site 692420001964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420001965 binding surface 692420001966 TPR motif; other site 692420001967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420001968 binding surface 692420001969 TPR motif; other site 692420001970 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420001972 Walker A/P-loop; other site 692420001973 ATP binding site [chemical binding]; other site 692420001974 Q-loop/lid; other site 692420001975 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001976 ABC transporter; Region: ABC_tran_2; pfam12848 692420001977 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001978 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420001979 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420001980 DNA binding residues [nucleotide binding] 692420001981 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420001982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001983 putative substrate translocation pore; other site 692420001984 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420001986 Walker A/P-loop; other site 692420001987 ATP binding site [chemical binding]; other site 692420001988 Q-loop/lid; other site 692420001989 ABC transporter signature motif; other site 692420001990 Walker B; other site 692420001991 D-loop; other site 692420001992 H-loop/switch region; other site 692420001993 ABC transporter; Region: ABC_tran_2; pfam12848 692420001994 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420001995 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420001996 DEAD-like helicases superfamily; Region: DEXDc; smart00487 692420001997 ATP binding site [chemical binding]; other site 692420001998 Mg++ binding site [ion binding]; other site 692420001999 motif III; other site 692420002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420002001 nucleotide binding region [chemical binding]; other site 692420002002 ATP-binding site [chemical binding]; other site 692420002003 potential frameshift: common BLAST hit: gi|154685223|ref|YP_001420384.1| YfmJ 692420002004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002005 Prostaglandin dehydrogenases; Region: PGDH; cd05288 692420002006 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 692420002007 Heat induced stress protein YflT; Region: YflT; pfam11181 692420002008 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 692420002009 Pectate lyase; Region: Pec_lyase_C; cl01593 692420002010 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 692420002011 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 692420002012 transmembrane helices; other site 692420002013 BclB C-terminal domain; Region: exospore_TM; TIGR03721 692420002014 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 692420002015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420002016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420002017 dimer interface [polypeptide binding]; other site 692420002018 phosphorylation site [posttranslational modification] 692420002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002020 ATP binding site [chemical binding]; other site 692420002021 Mg2+ binding site [ion binding]; other site 692420002022 G-X-G motif; other site 692420002023 Response regulator receiver domain; Region: Response_reg; pfam00072 692420002024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002025 active site 692420002026 phosphorylation site [posttranslational modification] 692420002027 intermolecular recognition site; other site 692420002028 dimerization interface [polypeptide binding]; other site 692420002029 Histidine kinase; Region: His_kinase; pfam06580 692420002030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002031 ATP binding site [chemical binding]; other site 692420002032 Mg2+ binding site [ion binding]; other site 692420002033 G-X-G motif; other site 692420002034 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 692420002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002036 active site 692420002037 phosphorylation site [posttranslational modification] 692420002038 intermolecular recognition site; other site 692420002039 dimerization interface [polypeptide binding]; other site 692420002040 Helix-turn-helix domains; Region: HTH; cl00088 692420002041 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002042 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002043 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002044 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002045 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002046 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002047 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002048 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002049 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002050 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002051 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002052 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420002053 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 692420002054 active site 692420002055 catalytic site [active] 692420002056 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420002057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420002058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002059 ATP binding site [chemical binding]; other site 692420002060 Mg2+ binding site [ion binding]; other site 692420002061 G-X-G motif; other site 692420002062 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420002063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002064 active site 692420002065 phosphorylation site [posttranslational modification] 692420002066 intermolecular recognition site; other site 692420002067 dimerization interface [polypeptide binding]; other site 692420002068 Transcriptional regulator; Region: CitT; pfam12431 692420002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 692420002070 NMT1-like family; Region: NMT1_2; cl15260 692420002071 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420002072 Citrate transporter; Region: CitMHS; pfam03600 692420002073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420002074 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 692420002075 active site 692420002076 dimer interface [polypeptide binding]; other site 692420002077 Acylphosphatase; Region: Acylphosphatase; cl00551 692420002078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 692420002079 MOSC domain; Region: MOSC; pfam03473 692420002080 3-alpha domain; Region: 3-alpha; pfam03475 692420002081 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 692420002082 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 692420002083 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 692420002084 active site 692420002085 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 692420002086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420002087 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002088 active site turn [active] 692420002089 phosphorylation site [posttranslational modification] 692420002090 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 692420002091 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420002092 Sulfatase; Region: Sulfatase; cl10460 692420002093 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 692420002094 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 692420002095 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 692420002096 putative dimer interface [polypeptide binding]; other site 692420002097 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420002098 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420002099 potential frameshift: common BLAST hit: gi|154685251|ref|YP_001420412.1| TreP 692420002100 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002101 active site turn [active] 692420002102 phosphorylation site [posttranslational modification] 692420002103 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 692420002104 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420002105 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420002106 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420002107 Ca binding site [ion binding]; other site 692420002108 active site 692420002109 catalytic site [active] 692420002110 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 692420002111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420002112 DNA-binding site [nucleotide binding]; DNA binding site 692420002113 UTRA domain; Region: UTRA; cl01230 692420002114 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 692420002115 dimer interface [polypeptide binding]; other site 692420002116 FMN binding site [chemical binding]; other site 692420002117 YibE/F-like protein; Region: YibE_F; cl02259 692420002118 YibE/F-like protein; Region: YibE_F; cl02259 692420002119 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 692420002120 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 692420002121 active site 692420002122 metal binding site [ion binding]; metal-binding site 692420002123 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002124 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 692420002125 active site 692420002126 metal binding site [ion binding]; metal-binding site 692420002127 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002128 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 692420002129 intracellular protease, PfpI family; Region: PfpI; TIGR01382 692420002130 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 692420002131 proposed catalytic triad [active] 692420002132 conserved cys residue [active] 692420002133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420002134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420002135 DNA binding site [nucleotide binding] 692420002136 domain linker motif; other site 692420002137 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 692420002138 putative dimerization interface [polypeptide binding]; other site 692420002139 putative ligand binding site [chemical binding]; other site 692420002140 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 692420002141 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 692420002142 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 692420002143 shikimate binding site; other site 692420002144 NAD(P) binding site [chemical binding]; other site 692420002145 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 692420002146 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 692420002147 active site 692420002148 catalytic residue [active] 692420002149 dimer interface [polypeptide binding]; other site 692420002150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420002152 putative substrate translocation pore; other site 692420002153 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 692420002154 Low molecular weight phosphatase family; Region: LMWPc; cd00115 692420002155 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 692420002156 active site 692420002157 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 692420002158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420002160 putative substrate translocation pore; other site 692420002161 calcium/proton exchanger (cax); Region: cax; TIGR00378 692420002162 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 692420002163 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 692420002164 YfkD-like protein; Region: YfkD; pfam14167 692420002165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420002166 potential frameshift: common BLAST hit: gi|154685272|ref|YP_001420433.1| YfkA 692420002167 YfkB-like domain; Region: YfkB; pfam08756 692420002168 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 692420002169 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 692420002170 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 692420002171 NodB motif; other site 692420002172 active site 692420002173 catalytic site [active] 692420002174 Cd binding site [ion binding]; other site 692420002175 potential frameshift: common BLAST hit: gi|154685275|ref|YP_001420436.1| YfjR 692420002176 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 692420002177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002178 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 692420002179 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 692420002180 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 692420002181 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 692420002182 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 692420002183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420002184 minor groove reading motif; other site 692420002185 helix-hairpin-helix signature motif; other site 692420002186 substrate binding pocket [chemical binding]; other site 692420002187 active site 692420002188 TRAM domain; Region: TRAM; cl01282 692420002189 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 692420002190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420002191 S-adenosylmethionine binding site [chemical binding]; other site 692420002192 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 692420002193 active site 692420002194 catalytic residues [active] 692420002195 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420002197 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 692420002198 Walker A/P-loop; other site 692420002199 ATP binding site [chemical binding]; other site 692420002200 Q-loop/lid; other site 692420002201 ABC transporter signature motif; other site 692420002202 Walker B; other site 692420002203 D-loop; other site 692420002204 H-loop/switch region; other site 692420002205 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420002206 active site 692420002207 ATP binding site [chemical binding]; other site 692420002208 substrate binding site [chemical binding]; other site 692420002209 activation loop (A-loop); other site 692420002210 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 692420002211 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 692420002212 active site 692420002213 zinc binding site [ion binding]; other site 692420002214 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 692420002215 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 692420002216 FMN binding site [chemical binding]; other site 692420002217 active site 692420002218 catalytic residues [active] 692420002219 substrate binding site [chemical binding]; other site 692420002220 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 692420002221 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420002222 tetramer interface [polypeptide binding]; other site 692420002223 TPP-binding site [chemical binding]; other site 692420002224 heterodimer interface [polypeptide binding]; other site 692420002225 phosphorylation loop region [posttranslational modification] 692420002226 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420002227 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420002228 alpha subunit interface [polypeptide binding]; other site 692420002229 TPP binding site [chemical binding]; other site 692420002230 heterodimer interface [polypeptide binding]; other site 692420002231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420002232 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420002233 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420002234 E3 interaction surface; other site 692420002235 lipoyl attachment site [posttranslational modification]; other site 692420002236 e3 binding domain; Region: E3_binding; pfam02817 692420002237 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 692420002238 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 692420002239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420002240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420002241 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 692420002242 GAF domain; Region: GAF; cl15785 692420002243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420002244 Walker A motif; other site 692420002245 ATP binding site [chemical binding]; other site 692420002246 Walker B motif; other site 692420002247 arginine finger; other site 692420002248 Helix-turn-helix domains; Region: HTH; cl00088 692420002249 Small acid-soluble spore protein H family; Region: SspH; cl06949 692420002250 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 692420002251 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 692420002252 NAD binding site [chemical binding]; other site 692420002253 sugar binding site [chemical binding]; other site 692420002254 divalent metal binding site [ion binding]; other site 692420002255 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420002256 dimer interface [polypeptide binding]; other site 692420002257 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420002258 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420002259 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420002260 putative active site [active] 692420002261 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 692420002262 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420002263 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002264 active site turn [active] 692420002265 phosphorylation site [posttranslational modification] 692420002266 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420002267 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 692420002268 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420002269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002270 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420002272 Walker A/P-loop; other site 692420002273 ATP binding site [chemical binding]; other site 692420002274 Q-loop/lid; other site 692420002275 ABC transporter signature motif; other site 692420002276 Walker B; other site 692420002277 D-loop; other site 692420002278 H-loop/switch region; other site 692420002279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002280 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002281 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 692420002282 Walker A/P-loop; other site 692420002283 ATP binding site [chemical binding]; other site 692420002284 Q-loop/lid; other site 692420002285 ABC transporter signature motif; other site 692420002286 Walker B; other site 692420002287 D-loop; other site 692420002288 H-loop/switch region; other site 692420002289 DoxX; Region: DoxX; cl00976 692420002290 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 692420002291 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 692420002292 putative metal binding site [ion binding]; other site 692420002293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420002294 active site 692420002295 metal binding site [ion binding]; metal-binding site 692420002296 potential frameshift: common BLAST hit: gi|154685298|ref|YP_001420459.1| CtaO 692420002297 similar to heme O synthase (minor enzyme) fragment; Protoheme IX farnesyltransferase 1; Heme O synthase 1; Heme B farnesyltransferase 1;, UbiA prenyltransferase 692420002298 similar to protoheme IX farnesyltransferase fragment; Protoheme IX farnesyltransferase 1; Heme O synthase 1; Heme B farnesyltransferase 1;, UbiA prenyltransferase, cyoE_ctaB: protoheme IX farnesyltransferase 692420002299 Helix-turn-helix domains; Region: HTH; cl00088 692420002300 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 692420002301 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420002302 OpgC protein; Region: OpgC_C; cl00792 692420002303 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 692420002304 RNAase interaction site [polypeptide binding]; other site 692420002305 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420002306 DinB superfamily; Region: DinB_2; pfam12867 692420002307 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420002308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002309 putative substrate translocation pore; other site 692420002310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002311 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420002312 Helix-turn-helix domains; Region: HTH; cl00088 692420002313 Predicted integral membrane protein [Function unknown]; Region: COG0392 692420002314 Uncharacterized conserved protein [Function unknown]; Region: COG2898 692420002315 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 692420002316 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 692420002317 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 692420002318 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 692420002319 putative FMN binding site [chemical binding]; other site 692420002320 YfhD-like protein; Region: YfhD; pfam14151 692420002321 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 692420002322 TIGR01777 family protein; Region: yfcH 692420002323 putative NAD(P) binding site [chemical binding]; other site 692420002324 putative active site [active] 692420002325 RecX family; Region: RecX; cl00936 692420002326 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 692420002327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002328 putative substrate translocation pore; other site 692420002329 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 692420002330 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 692420002331 Small acid-soluble spore protein K family; Region: SspK; cl11509 692420002332 WVELL protein; Region: WVELL; pfam14043 692420002333 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 692420002334 Bacterial SH3 domain; Region: SH3_3; cl02551 692420002335 potential frameshift: common BLAST hit: gi|154685322|ref|YP_001420483.1| YfhM 692420002336 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 692420002337 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420002338 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 692420002339 Ligand binding site; other site 692420002340 Putative Catalytic site; other site 692420002341 DXD motif; other site 692420002342 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 692420002343 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 692420002344 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 692420002345 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420002346 Int/Topo IB signature motif; other site 692420002347 Domain of unknown function (DUF955); Region: DUF955; cl01076 692420002348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002349 non-specific DNA binding site [nucleotide binding]; other site 692420002350 salt bridge; other site 692420002351 sequence-specific DNA binding site [nucleotide binding]; other site 692420002352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420002353 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 692420002354 ORF6C domain; Region: ORF6C; pfam10552 692420002355 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 692420002356 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 692420002357 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 692420002358 replicative DNA helicase; Region: DnaB; TIGR00665 692420002359 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 692420002360 Walker A motif; other site 692420002361 ATP binding site [chemical binding]; other site 692420002362 Walker B motif; other site 692420002363 DNA binding loops [nucleotide binding] 692420002364 positive control sigma-like factor; Validated; Region: PRK06930 692420002365 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002366 DNA binding residues [nucleotide binding] 692420002367 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 692420002368 YcfA-like protein; Region: YcfA; cl00752 692420002369 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 692420002370 Phage terminase, small subunit; Region: Terminase_4; cl01525 692420002371 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 692420002372 Phage Terminase; Region: Terminase_1; pfam03354 692420002373 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420002374 Phage portal protein; Region: Phage_portal; pfam04860 692420002375 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 692420002376 oligomer interface [polypeptide binding]; other site 692420002377 active site residues [active] 692420002378 Phage capsid family; Region: Phage_capsid; pfam05065 692420002379 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 692420002380 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 692420002381 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420002382 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002383 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 692420002384 Phage tail protein; Region: Sipho_tail; pfam05709 692420002385 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420002386 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 692420002387 active site 692420002388 catalytic triad [active] 692420002389 oxyanion hole [active] 692420002390 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420002391 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 692420002392 dimer interface [polypeptide binding]; other site 692420002393 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 692420002394 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420002395 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 692420002396 Phage lysis protein, holin; Region: Phage_holin; cl04675 692420002397 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420002398 amidase catalytic site [active] 692420002399 Zn binding residues [ion binding]; other site 692420002400 substrate binding site [chemical binding]; other site 692420002401 Bacterial SH3 domain; Region: SH3_3; cl02551 692420002402 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420002403 potential frameshift: common BLAST hit: gi|52784550|ref|YP_090379.1| RapK 692420002404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420002405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420002406 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 692420002407 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420002408 minor groove reading motif; other site 692420002409 helix-hairpin-helix signature motif; other site 692420002410 substrate binding pocket [chemical binding]; other site 692420002411 active site 692420002412 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 692420002413 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 692420002414 DNA binding and oxoG recognition site [nucleotide binding] 692420002415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 692420002416 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 692420002417 putative NAD(P) binding site [chemical binding]; other site 692420002418 active site 692420002419 YgaB-like protein; Region: YgaB; pfam14182 692420002420 Protein of unknown function (DUF402); Region: DUF402; cl00979 692420002421 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002422 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002423 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 692420002424 Walker A/P-loop; other site 692420002425 ATP binding site [chemical binding]; other site 692420002426 Q-loop/lid; other site 692420002427 ABC transporter signature motif; other site 692420002428 Walker B; other site 692420002429 D-loop; other site 692420002430 H-loop/switch region; other site 692420002431 Predicted membrane protein [Function unknown]; Region: COG4129 692420002432 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 692420002433 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 692420002434 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420002435 inhibitor-cofactor binding pocket; inhibition site 692420002436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002437 catalytic residue [active] 692420002438 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 692420002439 catalytic triad [active] 692420002440 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420002441 metal binding site 2 [ion binding]; metal-binding site 692420002442 putative DNA binding helix; other site 692420002443 metal binding site 1 [ion binding]; metal-binding site 692420002444 dimer interface [polypeptide binding]; other site 692420002445 structural Zn2+ binding site [ion binding]; other site 692420002446 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 692420002447 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 692420002448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420002449 Int/Topo IB signature motif; other site 692420002450 active site 692420002451 DNA binding site [nucleotide binding] 692420002452 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420002453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420002454 hypothetical protein; Validated; Region: PRK08116 692420002455 replicative DNA helicase; Region: DnaB; TIGR00665 692420002456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420002457 Walker A motif; other site 692420002458 ATP binding site [chemical binding]; other site 692420002459 Walker B motif; other site 692420002460 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 692420002461 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 692420002462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002463 non-specific DNA binding site [nucleotide binding]; other site 692420002464 salt bridge; other site 692420002465 sequence-specific DNA binding site [nucleotide binding]; other site 692420002466 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 692420002467 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 692420002468 active site 692420002469 catalytic site [active] 692420002470 substrate binding site [chemical binding]; other site 692420002471 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 692420002472 active site 692420002473 DNA binding site [nucleotide binding] 692420002474 catalytic site [active] 692420002475 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 692420002476 active site 692420002477 putative DNA-binding cleft [nucleotide binding]; other site 692420002478 dimer interface [polypeptide binding]; other site 692420002479 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420002480 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 692420002481 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 692420002482 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 692420002483 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 692420002484 GIY-YIG motif/motif A; other site 692420002485 putative active site [active] 692420002486 catalytic site [active] 692420002487 putative metal binding site [ion binding]; other site 692420002488 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912 692420002489 DNA binding site [nucleotide binding] 692420002490 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 692420002491 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 692420002492 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 692420002493 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 692420002494 dimer interface [polypeptide binding]; other site 692420002495 putative radical transfer pathway; other site 692420002496 diiron center [ion binding]; other site 692420002497 tyrosyl radical; other site 692420002498 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 692420002499 trimer interface [polypeptide binding]; other site 692420002500 active site 692420002501 Thymidylate synthase complementing protein; Region: Thy1; cl03630 692420002502 3D domain; Region: 3D; cl01439 692420002503 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 692420002504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420002505 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 692420002506 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420002507 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 692420002508 cofactor binding site; other site 692420002509 DNA binding site [nucleotide binding] 692420002510 substrate interaction site [chemical binding]; other site 692420002511 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 692420002512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002513 DNA binding residues [nucleotide binding] 692420002514 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 692420002515 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 692420002516 active site 692420002517 DNA binding site [nucleotide binding] 692420002518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420002519 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 692420002520 Int/Topo IB signature motif; other site 692420002521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 692420002522 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 692420002523 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 692420002524 Helix-turn-helix domains; Region: HTH; cl00088 692420002525 DNA-binding interface [nucleotide binding]; DNA binding site 692420002526 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 692420002527 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 692420002528 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 692420002529 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002530 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002531 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 692420002532 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 692420002533 Phage tail protein; Region: Sipho_tail; pfam05709 692420002534 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420002535 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420002536 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420002537 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420002538 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420002539 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 692420002540 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420002541 amidase catalytic site [active] 692420002542 Zn binding residues [ion binding]; other site 692420002543 substrate binding site [chemical binding]; other site 692420002544 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002545 putative peptidoglycan binding site; other site 692420002546 Phage holin; Region: Phage_holin_5; pfam06946 692420002547 YolD-like protein; Region: YolD; pfam08863 692420002548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420002549 Helix-turn-helix domains; Region: HTH; cl00088 692420002550 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 692420002551 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420002552 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 692420002553 active site pocket [active] 692420002554 oxyanion hole [active] 692420002555 catalytic triad [active] 692420002556 active site nucleophile [active] 692420002557 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 692420002558 ThiC-associated domain; Region: ThiC-associated; pfam13667 692420002559 ThiC family; Region: ThiC; cl08031 692420002560 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420002561 FAD binding domain; Region: FAD_binding_4; pfam01565 692420002562 Berberine and berberine like; Region: BBE; pfam08031 692420002563 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420002564 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 692420002565 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 692420002566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002568 dimer interface [polypeptide binding]; other site 692420002569 conserved gate region; other site 692420002570 putative PBP binding loops; other site 692420002571 ABC-ATPase subunit interface; other site 692420002572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420002573 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002575 dimer interface [polypeptide binding]; other site 692420002576 conserved gate region; other site 692420002577 putative PBP binding loops; other site 692420002578 ABC-ATPase subunit interface; other site 692420002579 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420002580 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420002581 Walker A/P-loop; other site 692420002582 ATP binding site [chemical binding]; other site 692420002583 Q-loop/lid; other site 692420002584 ABC transporter signature motif; other site 692420002585 Walker B; other site 692420002586 D-loop; other site 692420002587 H-loop/switch region; other site 692420002588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420002589 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 692420002590 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420002591 Walker A/P-loop; other site 692420002592 ATP binding site [chemical binding]; other site 692420002593 Q-loop/lid; other site 692420002594 ABC transporter signature motif; other site 692420002595 Walker B; other site 692420002596 D-loop; other site 692420002597 H-loop/switch region; other site 692420002598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420002599 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 692420002600 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 692420002601 tetramer interface [polypeptide binding]; other site 692420002602 heme binding pocket [chemical binding]; other site 692420002603 NADPH binding site [chemical binding]; other site 692420002604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 692420002605 active site 692420002606 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 692420002607 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 692420002608 Walker A/P-loop; other site 692420002609 ATP binding site [chemical binding]; other site 692420002610 Q-loop/lid; other site 692420002611 ABC transporter signature motif; other site 692420002612 Walker B; other site 692420002613 D-loop; other site 692420002614 H-loop/switch region; other site 692420002615 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 692420002616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420002617 substrate binding pocket [chemical binding]; other site 692420002618 membrane-bound complex binding site; other site 692420002619 hinge residues; other site 692420002620 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 692420002621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002622 dimer interface [polypeptide binding]; other site 692420002623 conserved gate region; other site 692420002624 putative PBP binding loops; other site 692420002625 ABC-ATPase subunit interface; other site 692420002626 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 692420002627 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 692420002628 active site 692420002629 dimer interface [polypeptide binding]; other site 692420002630 non-prolyl cis peptide bond; other site 692420002631 insertion regions; other site 692420002632 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 692420002633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002634 non-specific DNA binding site [nucleotide binding]; other site 692420002635 salt bridge; other site 692420002636 sequence-specific DNA binding site [nucleotide binding]; other site 692420002637 B3/4 domain; Region: B3_4; cl11458 692420002638 iron-sulfur cluster binding protein, putative; Region: TIGR00276 692420002639 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 692420002640 HEAT repeats; Region: HEAT_2; pfam13646 692420002641 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 692420002642 NlpC/P60 family; Region: NLPC_P60; cl11438 692420002643 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 692420002644 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 692420002645 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 692420002646 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 692420002647 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 692420002648 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 692420002649 Uncharacterized conserved protein [Function unknown]; Region: COG2718 692420002650 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 692420002651 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420002652 Helix-turn-helix domains; Region: HTH; cl00088 692420002653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420002654 carboxyltransferase (CT) interaction site; other site 692420002655 biotinylation site [posttranslational modification]; other site 692420002656 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 692420002657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002659 putative substrate translocation pore; other site 692420002660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002661 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420002662 Predicted transcriptional regulators [Transcription]; Region: COG1725 692420002663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420002664 DNA-binding site [nucleotide binding]; DNA binding site 692420002665 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 692420002666 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 692420002667 Walker A/P-loop; other site 692420002668 ATP binding site [chemical binding]; other site 692420002669 Q-loop/lid; other site 692420002670 ABC transporter signature motif; other site 692420002671 Walker B; other site 692420002672 D-loop; other site 692420002673 H-loop/switch region; other site 692420002674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420002675 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 692420002676 Walker A/P-loop; other site 692420002677 ATP binding site [chemical binding]; other site 692420002678 Q-loop/lid; other site 692420002679 ABC transporter signature motif; other site 692420002680 Walker B; other site 692420002681 D-loop; other site 692420002682 H-loop/switch region; other site 692420002683 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420002684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 692420002685 DNA-binding site [nucleotide binding]; DNA binding site 692420002686 RNA-binding motif; other site 692420002687 NMT1-like family; Region: NMT1_2; cl15260 692420002688 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420002689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420002690 metal binding site [ion binding]; metal-binding site 692420002691 active site 692420002692 I-site; other site 692420002693 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420002694 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420002695 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 692420002696 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 692420002697 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420002698 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 692420002699 Coat F domain; Region: Coat_F; cl15836 692420002700 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 692420002701 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 692420002702 putative active site [active] 692420002703 putative metal binding site [ion binding]; other site 692420002704 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002705 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 692420002706 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 692420002707 active site 692420002708 catalytic site [active] 692420002709 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 692420002710 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 692420002711 active site 692420002712 FOG: CBS domain [General function prediction only]; Region: COG0517 692420002713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 692420002714 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 692420002715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420002716 motif II; other site 692420002717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420002718 Coenzyme A binding pocket [chemical binding]; other site 692420002719 Predicted amidohydrolase [General function prediction only]; Region: COG0388 692420002720 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 692420002721 putative active site [active] 692420002722 catalytic triad [active] 692420002723 putative dimer interface [polypeptide binding]; other site 692420002724 aminotransferase; Validated; Region: PRK07678 692420002725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420002726 inhibitor-cofactor binding pocket; inhibition site 692420002727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002728 catalytic residue [active] 692420002729 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 692420002730 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 692420002731 amphipathic channel; other site 692420002732 Asn-Pro-Ala signature motifs; other site 692420002733 glycerol kinase; Provisional; Region: glpK; PRK00047 692420002734 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 692420002735 N- and C-terminal domain interface [polypeptide binding]; other site 692420002736 active site 692420002737 MgATP binding site [chemical binding]; other site 692420002738 catalytic site [active] 692420002739 metal binding site [ion binding]; metal-binding site 692420002740 glycerol binding site [chemical binding]; other site 692420002741 homotetramer interface [polypeptide binding]; other site 692420002742 homodimer interface [polypeptide binding]; other site 692420002743 FBP binding site [chemical binding]; other site 692420002744 protein IIAGlc interface [polypeptide binding]; other site 692420002745 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 692420002746 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 692420002747 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 692420002748 active site 692420002749 substrate binding site [chemical binding]; other site 692420002750 metal binding site [ion binding]; metal-binding site 692420002751 GAF domain; Region: GAF_2; pfam13185 692420002752 GAF domain; Region: GAF; cl15785 692420002753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 692420002754 Histidine kinase; Region: HisKA_3; pfam07730 692420002755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002756 ATP binding site [chemical binding]; other site 692420002757 Mg2+ binding site [ion binding]; other site 692420002758 G-X-G motif; other site 692420002759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420002760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002761 active site 692420002762 phosphorylation site [posttranslational modification] 692420002763 intermolecular recognition site; other site 692420002764 dimerization interface [polypeptide binding]; other site 692420002765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420002766 DNA binding residues [nucleotide binding] 692420002767 dimerization interface [polypeptide binding]; other site 692420002768 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420002769 YhdB-like protein; Region: YhdB; pfam14148 692420002770 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 692420002771 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002772 putative peptidoglycan binding site; other site 692420002773 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002774 putative peptidoglycan binding site; other site 692420002775 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002776 putative peptidoglycan binding site; other site 692420002777 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002778 putative peptidoglycan binding site; other site 692420002779 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420002780 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002781 putative peptidoglycan binding site; other site 692420002782 NlpC/P60 family; Region: NLPC_P60; cl11438 692420002783 Helix-turn-helix domains; Region: HTH; cl00088 692420002784 Rrf2 family protein; Region: rrf2_super; TIGR00738 692420002785 Conserved TM helix; Region: TM_helix; pfam05552 692420002786 Conserved TM helix; Region: TM_helix; pfam05552 692420002787 Conserved TM helix; Region: TM_helix; pfam05552 692420002788 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 692420002789 SpoVR like protein; Region: SpoVR; pfam04293 692420002790 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 692420002791 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 692420002792 dimer interface [polypeptide binding]; other site 692420002793 active site 692420002794 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002795 putative peptidoglycan binding site; other site 692420002796 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420002797 putative peptidoglycan binding site; other site 692420002798 NlpC/P60 family; Region: NLPC_P60; cl11438 692420002799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420002800 Helix-turn-helix domains; Region: HTH; cl00088 692420002801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420002802 dimerization interface [polypeptide binding]; other site 692420002803 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 692420002804 dimer interface [polypeptide binding]; other site 692420002805 Citrate synthase; Region: Citrate_synt; pfam00285 692420002806 active site 692420002807 citrylCoA binding site [chemical binding]; other site 692420002808 oxalacetate/citrate binding site [chemical binding]; other site 692420002809 coenzyme A binding site [chemical binding]; other site 692420002810 catalytic triad [active] 692420002811 short chain dehydrogenase; Provisional; Region: PRK06701 692420002812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002813 NAD(P) binding site [chemical binding]; other site 692420002814 active site 692420002815 Spore germination protein; Region: Spore_permease; cl15802 692420002816 amino acid transporter; Region: 2A0306; TIGR00909 692420002817 Spore germination protein; Region: Spore_permease; cl15802 692420002818 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 692420002819 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 692420002820 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 692420002821 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 692420002822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420002823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002824 DNA binding residues [nucleotide binding] 692420002825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 692420002826 putative acyl-acceptor binding pocket; other site 692420002827 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420002828 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420002829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420002830 Transporter associated domain; Region: CorC_HlyC; cl08393 692420002831 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 692420002832 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420002833 DNA binding residues [nucleotide binding] 692420002834 putative dimer interface [polypeptide binding]; other site 692420002835 aspartate aminotransferase; Provisional; Region: PRK06836 692420002836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420002837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002838 homodimer interface [polypeptide binding]; other site 692420002839 catalytic residue [active] 692420002840 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 692420002841 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420002842 dimer interface [polypeptide binding]; other site 692420002843 active site 692420002844 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420002845 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420002846 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420002847 Transporter associated domain; Region: CorC_HlyC; cl08393 692420002848 CrcB-like protein; Region: CRCB; cl09114 692420002849 CrcB-like protein; Region: CRCB; cl09114 692420002850 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 692420002851 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 692420002852 active site 692420002853 catalytic site [active] 692420002854 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 692420002855 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420002856 NAD-dependent deacetylase; Provisional; Region: PRK00481 692420002857 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 692420002858 NAD+ binding site [chemical binding]; other site 692420002859 substrate binding site [chemical binding]; other site 692420002860 Zn binding site [ion binding]; other site 692420002861 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 692420002862 NodB motif; other site 692420002863 active site 692420002864 catalytic site [active] 692420002865 Zn binding site [ion binding]; other site 692420002866 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 692420002867 homodimer interface [polypeptide binding]; other site 692420002868 substrate-cofactor binding pocket; other site 692420002869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002870 catalytic residue [active] 692420002871 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 692420002872 Helix-turn-helix domains; Region: HTH; cl00088 692420002873 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 692420002874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 692420002875 Ligand Binding Site [chemical binding]; other site 692420002876 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002877 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 692420002878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420002879 Walker A/P-loop; other site 692420002880 ATP binding site [chemical binding]; other site 692420002881 Q-loop/lid; other site 692420002882 ABC transporter signature motif; other site 692420002883 Walker B; other site 692420002884 D-loop; other site 692420002885 H-loop/switch region; other site 692420002886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002887 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420002888 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 692420002889 Walker A/P-loop; other site 692420002890 ATP binding site [chemical binding]; other site 692420002891 Q-loop/lid; other site 692420002892 ABC transporter signature motif; other site 692420002893 Walker B; other site 692420002894 D-loop; other site 692420002895 H-loop/switch region; other site 692420002896 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 692420002897 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420002898 NAD binding site [chemical binding]; other site 692420002899 substrate binding site [chemical binding]; other site 692420002900 putative active site [active] 692420002901 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420002902 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420002903 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 692420002905 Protein of unknown function (DUF964); Region: DUF964; cl01483 692420002906 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420002907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420002908 active site 692420002909 motif I; other site 692420002910 motif II; other site 692420002911 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420002912 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 692420002913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420002914 FeS/SAM binding site; other site 692420002915 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 692420002916 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 692420002917 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 692420002918 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 692420002919 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 692420002920 enoyl-CoA hydratase; Provisional; Region: PRK07659 692420002921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420002922 substrate binding site [chemical binding]; other site 692420002923 oxyanion hole (OAH) forming residues; other site 692420002924 trimer interface [polypeptide binding]; other site 692420002925 YhzD-like protein; Region: YhzD; pfam14120 692420002926 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 692420002927 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 692420002928 Walker A/P-loop; other site 692420002929 ATP binding site [chemical binding]; other site 692420002930 Q-loop/lid; other site 692420002931 ABC transporter signature motif; other site 692420002932 Walker B; other site 692420002933 D-loop; other site 692420002934 H-loop/switch region; other site 692420002935 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 692420002936 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420002937 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 692420002938 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420002939 active site 692420002940 metal binding site [ion binding]; metal-binding site 692420002941 DNA binding site [nucleotide binding] 692420002942 Uncharacterized conserved protein [Function unknown]; Region: COG4717 692420002943 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 692420002944 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 692420002945 generic binding surface II; other site 692420002946 generic binding surface I; other site 692420002947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420002948 Zn2+ binding site [ion binding]; other site 692420002949 Mg2+ binding site [ion binding]; other site 692420002950 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 692420002951 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 692420002952 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 692420002953 PPIC-type PPIASE domain; Region: Rotamase; cl08278 692420002954 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 692420002955 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 692420002956 transcriptional regulator Hpr; Provisional; Region: PRK13777 692420002957 Helix-turn-helix domains; Region: HTH; cl00088 692420002958 YtxH-like protein; Region: YtxH; cl02079 692420002959 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 692420002960 homodimer interface [polypeptide binding]; other site 692420002961 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420002962 substrate-cofactor binding pocket; other site 692420002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002964 catalytic residue [active] 692420002965 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 692420002966 HIT family signature motif; other site 692420002967 catalytic residue [active] 692420002968 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420002969 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 692420002970 Walker A/P-loop; other site 692420002971 ATP binding site [chemical binding]; other site 692420002972 Q-loop/lid; other site 692420002973 ABC transporter signature motif; other site 692420002974 Walker B; other site 692420002975 D-loop; other site 692420002976 H-loop/switch region; other site 692420002977 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 692420002978 EcsC protein family; Region: EcsC; pfam12787 692420002979 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420002980 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 692420002981 metal binding site [ion binding]; metal-binding site 692420002982 dimer interface [polypeptide binding]; other site 692420002983 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420002984 Transglycosylase; Region: Transgly; cl07896 692420002985 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420002986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420002987 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 692420002988 substrate binding site [chemical binding]; other site 692420002989 active site 692420002990 ferrochelatase; Provisional; Region: PRK12435 692420002991 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 692420002992 C-terminal domain interface [polypeptide binding]; other site 692420002993 active site 692420002994 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 692420002995 active site 692420002996 N-terminal domain interface [polypeptide binding]; other site 692420002997 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 692420002998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420003000 Helix-turn-helix domains; Region: HTH; cl00088 692420003001 Predicted membrane protein [Function unknown]; Region: COG1511 692420003002 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 692420003003 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420003004 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 692420003005 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 692420003006 dimer interface [polypeptide binding]; other site 692420003007 active site 692420003008 CoA binding pocket [chemical binding]; other site 692420003009 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420003010 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 692420003011 putative oligomer interface [polypeptide binding]; other site 692420003012 putative active site [active] 692420003013 metal binding site [ion binding]; metal-binding site 692420003014 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420003015 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420003016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420003017 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 692420003018 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 692420003019 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 692420003020 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 692420003021 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420003022 NAD(P) binding site [chemical binding]; other site 692420003023 putative active site [active] 692420003024 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 692420003025 AMP-binding enzyme; Region: AMP-binding; cl15778 692420003026 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420003027 Peptidase family M48; Region: Peptidase_M48; cl12018 692420003028 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420003029 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420003030 active site 692420003031 catalytic residues [active] 692420003032 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 692420003033 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 692420003034 siderophore binding site; other site 692420003035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 692420003036 catalytic core [active] 692420003037 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 692420003038 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420003039 dimer interface [polypeptide binding]; other site 692420003040 active site 692420003041 acyl-CoA synthetase; Validated; Region: PRK07638 692420003042 AMP-binding enzyme; Region: AMP-binding; cl15778 692420003043 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420003044 potential frameshift: common BLAST hit: gi|154685490|ref|YP_001420651.1| HemAT 692420003045 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 692420003046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420003047 dimer interface [polypeptide binding]; other site 692420003048 putative CheW interface [polypeptide binding]; other site 692420003049 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 692420003050 heme-binding site [chemical binding]; other site 692420003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003052 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 692420003053 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 692420003054 [2Fe-2S] cluster binding site [ion binding]; other site 692420003055 short chain dehydrogenase; Provisional; Region: PRK06701 692420003056 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 692420003057 NAD binding site [chemical binding]; other site 692420003058 metal binding site [ion binding]; metal-binding site 692420003059 active site 692420003060 IDEAL domain; Region: IDEAL; cl07452 692420003061 ComK protein; Region: ComK; cl11560 692420003062 Protein of unknown function (DUF419); Region: DUF419; cl15265 692420003063 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420003064 Sterol carrier protein domain; Region: SCP2_2; pfam13530 692420003065 Excalibur calcium-binding domain; Region: Excalibur; cl05460 692420003066 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 692420003067 Sodium:solute symporter family; Region: SSF; cl00456 692420003068 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 692420003069 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 692420003070 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420003071 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 692420003072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420003073 Catalytic site [active] 692420003074 hypothetical protein; Provisional; Region: PRK08244 692420003075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003077 Helix-turn-helix domains; Region: HTH; cl00088 692420003078 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 692420003079 Putative ammonia monooxygenase; Region: AmoA; pfam05145 692420003080 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 692420003081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003082 putative substrate translocation pore; other site 692420003083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003084 Helix-turn-helix domains; Region: HTH; cl00088 692420003085 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 692420003086 Uncharacterized conserved protein [Function unknown]; Region: COG1633 692420003087 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 692420003088 dinuclear metal binding motif [ion binding]; other site 692420003089 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420003090 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 692420003091 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 692420003092 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 692420003093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420003094 Family description; Region: UvrD_C_2; cl15862 692420003095 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 692420003096 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 692420003097 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 692420003098 active site 692420003099 metal binding site [ion binding]; metal-binding site 692420003100 DNA binding site [nucleotide binding] 692420003101 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 692420003102 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 692420003103 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 692420003104 Walker A/P-loop; other site 692420003105 ATP binding site [chemical binding]; other site 692420003106 Q-loop/lid; other site 692420003107 ABC transporter signature motif; other site 692420003108 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 692420003109 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 692420003110 ABC transporter signature motif; other site 692420003111 Walker B; other site 692420003112 D-loop; other site 692420003113 H-loop/switch region; other site 692420003114 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 692420003115 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420003116 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 692420003117 Spore germination protein GerPC; Region: GerPC; pfam10737 692420003118 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 692420003119 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420003120 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420003121 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 692420003122 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 692420003123 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 692420003124 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 692420003125 active site 692420003126 catalytic triad [active] 692420003127 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 692420003128 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 692420003129 active site 692420003130 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 692420003131 dimer interface [polypeptide binding]; other site 692420003132 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 692420003133 Ligand Binding Site [chemical binding]; other site 692420003134 Molecular Tunnel; other site 692420003135 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 692420003136 substrate binding pocket [chemical binding]; other site 692420003137 substrate-Mg2+ binding site; other site 692420003138 aspartate-rich region 1; other site 692420003139 aspartate-rich region 2; other site 692420003140 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 692420003141 MatE; Region: MatE; cl10513 692420003142 MatE; Region: MatE; cl10513 692420003143 Cupin domain; Region: Cupin_2; cl09118 692420003144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420003145 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420003146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420003147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420003148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420003149 DNA binding site [nucleotide binding] 692420003150 domain linker motif; other site 692420003151 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 692420003152 dimerization interface [polypeptide binding]; other site 692420003153 ligand binding site [chemical binding]; other site 692420003154 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003156 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 692420003157 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420003158 LysE type translocator; Region: LysE; cl00565 692420003159 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420003160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420003161 DNA-binding site [nucleotide binding]; DNA binding site 692420003162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003164 homodimer interface [polypeptide binding]; other site 692420003165 catalytic residue [active] 692420003166 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 692420003167 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420003168 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 692420003169 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 692420003170 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 692420003171 FAD binding site [chemical binding]; other site 692420003172 Protein of unknown function (DUF520); Region: DUF520; cl00723 692420003173 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 692420003174 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 692420003175 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 692420003176 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 692420003177 ligand binding site [chemical binding]; other site 692420003178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420003179 dimerization interface [polypeptide binding]; other site 692420003180 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420003181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420003182 dimer interface [polypeptide binding]; other site 692420003183 putative CheW interface [polypeptide binding]; other site 692420003184 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420003185 Cytochrome P450; Region: p450; pfam00067 692420003186 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 692420003187 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420003188 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420003189 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420003190 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420003191 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 692420003192 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 692420003193 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420003194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003195 motif II; other site 692420003196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003197 esterase; Provisional; Region: PRK10566 692420003198 Domain of unknown function DUF59; Region: DUF59; cl00941 692420003199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420003200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420003201 active site 692420003202 metal binding site [ion binding]; metal-binding site 692420003203 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420003204 FAD binding domain; Region: FAD_binding_4; pfam01565 692420003205 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 692420003206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003207 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 692420003208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 692420003210 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 692420003211 heterotetramer interface [polypeptide binding]; other site 692420003212 active site pocket [active] 692420003213 cleavage site 692420003214 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 692420003215 nucleotide binding site [chemical binding]; other site 692420003216 N-acetyl-L-glutamate binding site [chemical binding]; other site 692420003217 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 692420003218 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420003219 inhibitor-cofactor binding pocket; inhibition site 692420003220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003221 catalytic residue [active] 692420003222 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 692420003223 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 692420003224 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 692420003225 catalytic site [active] 692420003226 subunit interface [polypeptide binding]; other site 692420003227 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 692420003228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420003229 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420003230 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 692420003231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420003232 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420003233 ornithine carbamoyltransferase; Provisional; Region: PRK00779 692420003234 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 692420003235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003236 YjzC-like protein; Region: YjzC; pfam14168 692420003237 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 692420003238 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 692420003239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003240 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 692420003241 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 692420003242 putative ligand binding site [chemical binding]; other site 692420003243 ComZ; Region: ComZ; pfam10815 692420003244 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 692420003245 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 692420003246 dimer interface [polypeptide binding]; other site 692420003247 active site 692420003248 CoA binding pocket [chemical binding]; other site 692420003249 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 692420003250 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420003251 dimer interface [polypeptide binding]; other site 692420003252 active site 692420003253 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 692420003254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003255 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003256 Walker A/P-loop; other site 692420003257 ATP binding site [chemical binding]; other site 692420003258 Q-loop/lid; other site 692420003259 ABC transporter signature motif; other site 692420003260 Walker B; other site 692420003261 D-loop; other site 692420003262 H-loop/switch region; other site 692420003263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003264 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 692420003265 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003266 Walker A/P-loop; other site 692420003267 ATP binding site [chemical binding]; other site 692420003268 Q-loop/lid; other site 692420003269 ABC transporter signature motif; other site 692420003270 Walker B; other site 692420003271 D-loop; other site 692420003272 H-loop/switch region; other site 692420003273 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003274 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 692420003275 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 692420003276 peptide binding site [polypeptide binding]; other site 692420003277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420003278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003279 dimer interface [polypeptide binding]; other site 692420003280 conserved gate region; other site 692420003281 putative PBP binding loops; other site 692420003282 ABC-ATPase subunit interface; other site 692420003283 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003284 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003286 dimer interface [polypeptide binding]; other site 692420003287 conserved gate region; other site 692420003288 putative PBP binding loops; other site 692420003289 ABC-ATPase subunit interface; other site 692420003290 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 692420003291 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 692420003292 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 692420003293 active site 692420003294 HIGH motif; other site 692420003295 dimer interface [polypeptide binding]; other site 692420003296 KMSKS motif; other site 692420003297 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 692420003298 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 692420003299 peptide binding site [polypeptide binding]; other site 692420003300 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 692420003301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003302 dimer interface [polypeptide binding]; other site 692420003303 conserved gate region; other site 692420003304 putative PBP binding loops; other site 692420003305 ABC-ATPase subunit interface; other site 692420003306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003307 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003309 dimer interface [polypeptide binding]; other site 692420003310 conserved gate region; other site 692420003311 putative PBP binding loops; other site 692420003312 ABC-ATPase subunit interface; other site 692420003313 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003314 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003315 Walker A/P-loop; other site 692420003316 ATP binding site [chemical binding]; other site 692420003317 Q-loop/lid; other site 692420003318 ABC transporter signature motif; other site 692420003319 Walker B; other site 692420003320 D-loop; other site 692420003321 H-loop/switch region; other site 692420003322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003323 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003324 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003325 Walker A/P-loop; other site 692420003326 ATP binding site [chemical binding]; other site 692420003327 Q-loop/lid; other site 692420003328 ABC transporter signature motif; other site 692420003329 Walker B; other site 692420003330 D-loop; other site 692420003331 H-loop/switch region; other site 692420003332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003333 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 692420003334 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420003335 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 692420003336 ArsC family; Region: ArsC; pfam03960 692420003337 putative catalytic residues [active] 692420003338 thiol/disulfide switch; other site 692420003339 Integral membrane protein TerC family; Region: TerC; cl10468 692420003340 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 692420003341 Competence protein CoiA-like family; Region: CoiA; cl11541 692420003342 oligoendopeptidase F; Region: pepF; TIGR00181 692420003343 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 692420003344 active site 692420003345 Zn binding site [ion binding]; other site 692420003346 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 692420003347 Thioredoxin; Region: Thioredoxin_5; pfam13743 692420003348 catalytic residues [active] 692420003349 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 692420003350 apolar tunnel; other site 692420003351 heme binding site [chemical binding]; other site 692420003352 dimerization interface [polypeptide binding]; other site 692420003353 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 692420003354 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420003355 catalytic residue [active] 692420003356 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 692420003357 putative active site [active] 692420003358 putative metal binding residues [ion binding]; other site 692420003359 signature motif; other site 692420003360 putative triphosphate binding site [ion binding]; other site 692420003361 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420003362 synthetase active site [active] 692420003363 NTP binding site [chemical binding]; other site 692420003364 metal binding site [ion binding]; metal-binding site 692420003365 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 692420003366 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 692420003367 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 692420003368 active site 692420003369 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 692420003370 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 692420003371 active site 692420003372 metal binding site [ion binding]; metal-binding site 692420003373 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 692420003374 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 692420003375 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 692420003376 thiamine phosphate binding site [chemical binding]; other site 692420003377 active site 692420003378 pyrophosphate binding site [ion binding]; other site 692420003379 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 692420003380 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 692420003381 thiS-thiF/thiG interaction site; other site 692420003382 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 692420003383 ThiS interaction site; other site 692420003384 putative active site [active] 692420003385 tetramer interface [polypeptide binding]; other site 692420003386 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 692420003387 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420003388 ATP binding site [chemical binding]; other site 692420003389 substrate interface [chemical binding]; other site 692420003390 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 692420003391 dimer interface [polypeptide binding]; other site 692420003392 substrate binding site [chemical binding]; other site 692420003393 ATP binding site [chemical binding]; other site 692420003394 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 692420003395 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 692420003396 NAD binding site [chemical binding]; other site 692420003397 homotetramer interface [polypeptide binding]; other site 692420003398 homodimer interface [polypeptide binding]; other site 692420003399 substrate binding site [chemical binding]; other site 692420003400 active site 692420003401 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 692420003402 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 692420003403 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 692420003404 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003405 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003406 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003407 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 692420003408 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 692420003409 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 692420003410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420003411 Family description; Region: UvrD_C_2; cl15862 692420003412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420003413 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420003414 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420003415 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 692420003416 Walker A/P-loop; other site 692420003417 ATP binding site [chemical binding]; other site 692420003418 Q-loop/lid; other site 692420003419 ABC transporter signature motif; other site 692420003420 Walker B; other site 692420003421 D-loop; other site 692420003422 H-loop/switch region; other site 692420003423 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 692420003424 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420003425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420003426 Coenzyme A binding pocket [chemical binding]; other site 692420003427 hypothetical protein; Provisional; Region: PRK13679 692420003428 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420003429 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420003430 Putative esterase; Region: Esterase; pfam00756 692420003431 cystathionine gamma-synthase; Reviewed; Region: PRK08247 692420003432 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420003433 homodimer interface [polypeptide binding]; other site 692420003434 substrate-cofactor binding pocket; other site 692420003435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003436 catalytic residue [active] 692420003437 cystathionine beta-lyase; Provisional; Region: PRK08064 692420003438 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420003439 homodimer interface [polypeptide binding]; other site 692420003440 substrate-cofactor binding pocket; other site 692420003441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003442 catalytic residue [active] 692420003443 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 692420003444 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 692420003445 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 692420003446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003447 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 692420003448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420003449 Coenzyme A binding pocket [chemical binding]; other site 692420003450 potential frameshift: common BLAST hit: gi|16078957|ref|NP_389778.1| NTPase with transmembrane helices 692420003451 potential frameshift: common BLAST hit: gi|16078957|ref|NP_389778.1| NTPase with transmembrane helices 692420003452 YolD-like protein; Region: YolD; pfam08863 692420003453 Y-family of DNA polymerases; Region: PolY; cl12025 692420003454 active site 692420003455 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 692420003456 YoqO-like protein; Region: YoqO; pfam14037 692420003457 potential frameshift: common BLAST hit: gi|308069421|ref|YP_003871026.1| Kelch repeat protein 692420003458 Kelch motif; Region: Kelch_1; cl02701 692420003459 Kelch motif; Region: Kelch_1; cl02701 692420003460 Kelch motif; Region: Kelch_1; cl02701 692420003461 Kelch motif; Region: Kelch_1; cl02701 692420003462 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 692420003463 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420003464 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 692420003465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003467 putative substrate translocation pore; other site 692420003468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003469 Helix-turn-helix domains; Region: HTH; cl00088 692420003470 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 692420003471 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 692420003472 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420003473 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420003474 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 692420003475 P-loop; other site 692420003476 active site 692420003477 phosphorylation site [posttranslational modification] 692420003478 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420003479 methionine cluster; other site 692420003480 active site 692420003481 phosphorylation site [posttranslational modification] 692420003482 metal binding site [ion binding]; metal-binding site 692420003483 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420003484 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420003485 Helix-turn-helix domains; Region: HTH; cl00088 692420003486 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420003487 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 692420003488 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420003489 hypothetical protein; Provisional; Region: PRK09272 692420003490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003491 Helix-turn-helix domains; Region: HTH; cl00088 692420003492 MgtC family; Region: MgtC; pfam02308 692420003493 Putative motility protein; Region: YjfB_motility; pfam14070 692420003494 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 692420003495 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 692420003496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 692420003497 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 692420003498 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 692420003499 4Fe-4S binding domain; Region: Fer4; cl02805 692420003500 4Fe-4S binding domain; Region: Fer4; cl02805 692420003501 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 692420003502 Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029 692420003503 [4Fe-4S] binding site [ion binding]; other site 692420003504 molybdopterin cofactor binding site; other site 692420003505 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 692420003506 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 692420003507 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420003508 active site 692420003509 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420003510 glycosyltransferase, MGT family; Region: MGT; TIGR01426 692420003511 active site 692420003512 TDP-binding site; other site 692420003513 acceptor substrate-binding pocket; other site 692420003514 homodimer interface [polypeptide binding]; other site 692420003515 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420003516 Cytochrome P450; Region: p450; pfam00067 692420003517 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 692420003518 potential frameshift: common BLAST hit: gi|154685660|ref|YP_001420821.1| YjgC 692420003519 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 692420003520 molybdopterin cofactor binding site; other site 692420003521 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420003522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420003523 Walker A/P-loop; other site 692420003524 ATP binding site [chemical binding]; other site 692420003525 EamA-like transporter family; Region: EamA; cl01037 692420003526 Cupin domain; Region: Cupin_2; cl09118 692420003527 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 692420003528 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420003529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420003530 Glucuronate isomerase; Region: UxaC; cl00829 692420003531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420003532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420003533 DNA binding site [nucleotide binding] 692420003534 domain linker motif; other site 692420003535 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 692420003536 dimerization interface [polypeptide binding]; other site 692420003537 ligand binding site [chemical binding]; other site 692420003538 altronate oxidoreductase; Provisional; Region: PRK03643 692420003539 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 692420003540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420003541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420003542 active site 692420003543 phosphorylation site [posttranslational modification] 692420003544 intermolecular recognition site; other site 692420003545 dimerization interface [polypeptide binding]; other site 692420003546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420003547 DNA binding site [nucleotide binding] 692420003548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 692420003549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420003550 dimer interface [polypeptide binding]; other site 692420003551 phosphorylation site [posttranslational modification] 692420003552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420003553 ATP binding site [chemical binding]; other site 692420003554 Mg2+ binding site [ion binding]; other site 692420003555 G-X-G motif; other site 692420003556 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 692420003557 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420003558 DinB superfamily; Region: DinB_2; pfam12867 692420003559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420003560 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 692420003561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420003562 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420003563 amidase catalytic site [active] 692420003564 Zn binding residues [ion binding]; other site 692420003565 substrate binding site [chemical binding]; other site 692420003566 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003567 putative peptidoglycan binding site; other site 692420003568 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420003569 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 692420003570 Protein of unknown function (DUF867); Region: DUF867; cl01713 692420003571 Domain of unknown function (DUF955); Region: DUF955; cl01076 692420003572 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420003573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420003574 non-specific DNA binding site [nucleotide binding]; other site 692420003575 salt bridge; other site 692420003576 sequence-specific DNA binding site [nucleotide binding]; other site 692420003577 hypothetical protein; Provisional; Region: PRK06921 692420003578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420003579 Walker A motif; other site 692420003580 ATP binding site [chemical binding]; other site 692420003581 Walker B motif; other site 692420003582 positive control sigma-like factor; Validated; Region: PRK06930 692420003583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420003584 DNA binding residues [nucleotide binding] 692420003585 Phage terminase small subunit; Region: Phage_terminase; pfam10668 692420003586 Terminase small subunit; Region: Terminase_2; cl01513 692420003587 Phage terminase large subunit; Region: Terminase_3; cl12054 692420003588 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420003589 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 692420003590 Phage capsid family; Region: Phage_capsid; pfam05065 692420003591 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 692420003592 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 692420003593 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 692420003594 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 692420003595 Phage XkdN-like protein; Region: XkdN; pfam08890 692420003596 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420003597 AAA ATPase domain; Region: AAA_15; pfam13175 692420003598 membrane protein P6; Region: PHA01399 692420003599 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 692420003600 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420003601 catalytic residue [active] 692420003602 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 692420003603 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003604 putative peptidoglycan binding site; other site 692420003605 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 692420003606 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 692420003607 Baseplate J-like protein; Region: Baseplate_J; cl01294 692420003608 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 692420003609 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420003610 Haemolysin XhlA; Region: XhlA; pfam10779 692420003611 Phage lysis protein, holin; Region: Phage_holin; cl04675 692420003612 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420003613 amidase catalytic site [active] 692420003614 Zn binding residues [ion binding]; other site 692420003615 substrate binding site [chemical binding]; other site 692420003616 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003617 putative peptidoglycan binding site; other site 692420003618 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420003619 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 692420003620 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 692420003621 Phosphate transporter family; Region: PHO4; cl00396 692420003622 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 692420003623 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 692420003624 Spore germination protein; Region: Spore_permease; cl15802 692420003625 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420003626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420003627 Zn binding site [ion binding]; other site 692420003628 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420003629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420003630 Zn binding site [ion binding]; other site 692420003631 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 692420003632 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 692420003633 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 692420003634 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 692420003635 Ligand binding site; other site 692420003636 Putative Catalytic site; other site 692420003637 DXD motif; other site 692420003638 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 692420003639 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420003640 protein binding site [polypeptide binding]; other site 692420003641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003642 putative substrate translocation pore; other site 692420003643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003644 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 692420003645 SxDxEG motif; other site 692420003646 active site 692420003647 metal binding site [ion binding]; metal-binding site 692420003648 homopentamer interface [polypeptide binding]; other site 692420003649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003651 dimer interface [polypeptide binding]; other site 692420003652 conserved gate region; other site 692420003653 putative PBP binding loops; other site 692420003654 ABC-ATPase subunit interface; other site 692420003655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003656 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003658 dimer interface [polypeptide binding]; other site 692420003659 conserved gate region; other site 692420003660 putative PBP binding loops; other site 692420003661 ABC-ATPase subunit interface; other site 692420003662 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003663 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003664 Walker A/P-loop; other site 692420003665 ATP binding site [chemical binding]; other site 692420003666 Q-loop/lid; other site 692420003667 ABC transporter signature motif; other site 692420003668 Walker B; other site 692420003669 D-loop; other site 692420003670 H-loop/switch region; other site 692420003671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003672 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 692420003673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 692420003674 peptide binding site [polypeptide binding]; other site 692420003675 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 692420003676 dimer interface [polypeptide binding]; other site 692420003677 catalytic triad [active] 692420003678 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 692420003679 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 692420003680 active site 692420003681 NlpC/P60 family; Region: NLPC_P60; cl11438 692420003682 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 692420003683 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 692420003684 Walker A/P-loop; other site 692420003685 ATP binding site [chemical binding]; other site 692420003686 Q-loop/lid; other site 692420003687 ABC transporter signature motif; other site 692420003688 Walker B; other site 692420003689 D-loop; other site 692420003690 H-loop/switch region; other site 692420003691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003692 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 692420003693 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 692420003694 Amidinotransferase; Region: Amidinotransf; cl12043 692420003695 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 692420003696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420003697 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420003698 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420003699 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420003700 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 692420003701 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 692420003702 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 692420003703 putative active site [active] 692420003704 putative substrate binding site [chemical binding]; other site 692420003705 putative cosubstrate binding site; other site 692420003706 catalytic site [active] 692420003707 gamma-glutamyl kinase; Provisional; Region: PRK05429 692420003708 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 692420003709 nucleotide binding site [chemical binding]; other site 692420003710 homotetrameric interface [polypeptide binding]; other site 692420003711 putative phosphate binding site [ion binding]; other site 692420003712 putative allosteric binding site; other site 692420003713 PUA domain; Region: PUA; cl00607 692420003714 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 692420003715 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 692420003716 putative catalytic cysteine [active] 692420003717 OsmC-like protein; Region: OsmC; cl00767 692420003718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003719 Helix-turn-helix domains; Region: HTH; cl00088 692420003720 OsmC-like protein; Region: OsmC; cl00767 692420003721 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420003722 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 692420003723 putative metal binding site; other site 692420003724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420003725 binding surface 692420003726 TPR motif; other site 692420003727 TPR repeat; Region: TPR_11; pfam13414 692420003728 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 692420003729 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 692420003730 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 692420003731 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 692420003732 ligand binding site [chemical binding]; other site 692420003733 flexible hinge region; other site 692420003734 Helix-turn-helix domains; Region: HTH; cl00088 692420003735 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 692420003736 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 692420003737 THF binding site; other site 692420003738 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 692420003739 substrate binding site [chemical binding]; other site 692420003740 THF binding site; other site 692420003741 zinc-binding site [ion binding]; other site 692420003742 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420003743 active site 692420003744 catalytic residues [active] 692420003745 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420003746 Cobalt transport protein; Region: CbiQ; cl00463 692420003747 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 692420003748 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 692420003749 Walker A/P-loop; other site 692420003750 ATP binding site [chemical binding]; other site 692420003751 Q-loop/lid; other site 692420003752 ABC transporter signature motif; other site 692420003753 Walker B; other site 692420003754 D-loop; other site 692420003755 H-loop/switch region; other site 692420003756 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 692420003757 Walker A/P-loop; other site 692420003758 ATP binding site [chemical binding]; other site 692420003759 Q-loop/lid; other site 692420003760 ABC transporter signature motif; other site 692420003761 Walker B; other site 692420003762 D-loop; other site 692420003763 H-loop/switch region; other site 692420003764 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 692420003765 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 692420003766 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003767 putative peptidoglycan binding site; other site 692420003768 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003769 putative peptidoglycan binding site; other site 692420003770 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 692420003771 active site 692420003772 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 692420003773 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 692420003774 MgtE intracellular N domain; Region: MgtE_N; cl15244 692420003775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 692420003776 Divalent cation transporter; Region: MgtE; cl00786 692420003777 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 692420003778 DNA binding residues [nucleotide binding] 692420003779 putative dimer interface [polypeptide binding]; other site 692420003780 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003781 Helix-turn-helix domains; Region: HTH; cl00088 692420003782 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 692420003783 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 692420003784 active site 692420003785 DNA binding site [nucleotide binding] 692420003786 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 692420003787 nucleotide binding site [chemical binding]; other site 692420003788 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 692420003789 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 692420003790 putative DNA binding site [nucleotide binding]; other site 692420003791 putative homodimer interface [polypeptide binding]; other site 692420003792 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 692420003793 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 692420003794 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 692420003795 PAS domain; Region: PAS_9; pfam13426 692420003796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420003797 metal binding site [ion binding]; metal-binding site 692420003798 active site 692420003799 I-site; other site 692420003800 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 692420003801 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420003802 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420003803 Integral membrane protein TerC family; Region: TerC; cl10468 692420003804 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 692420003805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420003806 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 692420003807 transcription termination factor Rho; Provisional; Region: PRK12678 692420003808 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420003809 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 692420003810 Peptidase family M48; Region: Peptidase_M48; cl12018 692420003811 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 692420003812 Cation transport protein; Region: TrkH; cl10514 692420003813 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420003814 OpgC protein; Region: OpgC_C; cl00792 692420003815 Acyltransferase family; Region: Acyl_transf_3; pfam01757 692420003816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420003817 PAS domain; Region: PAS_9; pfam13426 692420003818 PAS domain; Region: PAS_9; pfam13426 692420003819 PAS domain S-box; Region: sensory_box; TIGR00229 692420003820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420003821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420003822 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 692420003823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420003824 dimer interface [polypeptide binding]; other site 692420003825 phosphorylation site [posttranslational modification] 692420003826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420003827 ATP binding site [chemical binding]; other site 692420003828 Mg2+ binding site [ion binding]; other site 692420003829 G-X-G motif; other site 692420003830 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 692420003831 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 692420003832 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420003833 DNA binding site [nucleotide binding] 692420003834 active site 692420003835 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 692420003836 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 692420003837 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420003838 Phosphotransferase enzyme family; Region: APH; pfam01636 692420003839 Predicted amidohydrolase [General function prediction only]; Region: COG0388 692420003840 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 692420003841 putative active site [active] 692420003842 catalytic triad [active] 692420003843 putative dimer interface [polypeptide binding]; other site 692420003844 transaminase; Reviewed; Region: PRK08068 692420003845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420003846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003847 homodimer interface [polypeptide binding]; other site 692420003848 catalytic residue [active] 692420003849 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 692420003850 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 692420003851 dimer interface [polypeptide binding]; other site 692420003852 active site 692420003853 catalytic residue [active] 692420003854 metal binding site [ion binding]; metal-binding site 692420003855 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 692420003856 intersubunit interface [polypeptide binding]; other site 692420003857 active site 692420003858 Zn2+ binding site [ion binding]; other site 692420003859 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 692420003860 Cupin domain; Region: Cupin_2; cl09118 692420003861 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420003862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 692420003863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420003864 dimer interface [polypeptide binding]; other site 692420003865 phosphorylation site [posttranslational modification] 692420003866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420003867 ATP binding site [chemical binding]; other site 692420003868 Mg2+ binding site [ion binding]; other site 692420003869 G-X-G motif; other site 692420003870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003871 Helix-turn-helix domains; Region: HTH; cl00088 692420003872 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 692420003873 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 692420003874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 692420003875 ligand binding site [chemical binding]; other site 692420003876 flagellar motor protein MotA; Validated; Region: PRK08124 692420003877 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 692420003878 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 692420003879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420003880 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 692420003881 Walker A motif; other site 692420003882 ATP binding site [chemical binding]; other site 692420003883 Walker B motif; other site 692420003884 arginine finger; other site 692420003885 UvrB/uvrC motif; Region: UVR; pfam02151 692420003886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420003887 Walker A motif; other site 692420003888 ATP binding site [chemical binding]; other site 692420003889 Walker B motif; other site 692420003890 arginine finger; other site 692420003891 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 692420003892 Uncharacterized membrane protein [Function unknown]; Region: COG3949 692420003893 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 692420003894 Ligand Binding Site [chemical binding]; other site 692420003895 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 692420003896 active site 692420003897 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 692420003898 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 692420003899 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 692420003900 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 692420003901 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 692420003902 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420003903 MatE; Region: MatE; cl10513 692420003904 MatE; Region: MatE; cl10513 692420003905 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420003906 catalytic residues [active] 692420003907 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 692420003908 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420003909 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420003910 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 692420003911 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 692420003912 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 692420003913 active site 692420003914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420003915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420003916 DNA binding site [nucleotide binding] 692420003917 domain linker motif; other site 692420003918 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 692420003919 putative dimerization interface [polypeptide binding]; other site 692420003920 putative ligand binding site [chemical binding]; other site 692420003921 CAT RNA binding domain; Region: CAT_RBD; cl03904 692420003922 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420003923 PRD domain; Region: PRD; cl15445 692420003924 PRD domain; Region: PRD; cl15445 692420003925 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 692420003926 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420003927 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420003928 active site turn [active] 692420003929 phosphorylation site [posttranslational modification] 692420003930 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 692420003931 HPr interaction site; other site 692420003932 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420003933 active site 692420003934 phosphorylation site [posttranslational modification] 692420003935 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 692420003936 dimerization domain swap beta strand [polypeptide binding]; other site 692420003937 regulatory protein interface [polypeptide binding]; other site 692420003938 active site 692420003939 regulatory phosphorylation site [posttranslational modification]; other site 692420003940 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 692420003941 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 692420003942 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 692420003943 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 692420003944 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 692420003945 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 692420003946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420003947 FeS/SAM binding site; other site 692420003948 Cache domain; Region: Cache_1; pfam02743 692420003949 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 692420003950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420003951 dimerization interface [polypeptide binding]; other site 692420003952 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420003953 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420003954 dimer interface [polypeptide binding]; other site 692420003955 putative CheW interface [polypeptide binding]; other site 692420003956 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 692420003957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003958 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 692420003959 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420003960 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420003961 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420003962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420003963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420003964 putative active site [active] 692420003965 heme pocket [chemical binding]; other site 692420003966 PAS fold; Region: PAS; pfam00989 692420003967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420003968 putative active site [active] 692420003969 heme pocket [chemical binding]; other site 692420003970 PAS fold; Region: PAS; pfam00989 692420003971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420003972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 692420003973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420003974 dimer interface [polypeptide binding]; other site 692420003975 phosphorylation site [posttranslational modification] 692420003976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420003977 ATP binding site [chemical binding]; other site 692420003978 Mg2+ binding site [ion binding]; other site 692420003979 G-X-G motif; other site 692420003980 aminotransferase A; Validated; Region: PRK07683 692420003981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420003982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003983 homodimer interface [polypeptide binding]; other site 692420003984 catalytic residue [active] 692420003985 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 692420003986 putative CheA interaction surface; other site 692420003987 Response regulator receiver domain; Region: Response_reg; pfam00072 692420003988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420003989 active site 692420003990 phosphorylation site [posttranslational modification] 692420003991 intermolecular recognition site; other site 692420003992 dimerization interface [polypeptide binding]; other site 692420003993 YkyB-like protein; Region: YkyB; pfam14177 692420003994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003995 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420003996 putative substrate translocation pore; other site 692420003997 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420003998 putative peptidoglycan binding site; other site 692420003999 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 692420004000 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 692420004001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420004002 putative active site [active] 692420004003 putative metal binding site [ion binding]; other site 692420004004 short chain dehydrogenase; Provisional; Region: PRK07677 692420004005 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 692420004006 NAD(P) binding site [chemical binding]; other site 692420004007 substrate binding site [chemical binding]; other site 692420004008 homotetramer interface [polypeptide binding]; other site 692420004009 active site 692420004010 homodimer interface [polypeptide binding]; other site 692420004011 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 692420004012 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 692420004013 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 692420004014 Protein of unknown function (DUF458); Region: DUF458; cl00861 692420004015 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 692420004016 FOG: CBS domain [General function prediction only]; Region: COG0517 692420004017 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 692420004018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420004019 Helix-turn-helix domains; Region: HTH; cl00088 692420004020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420004021 dimerization interface [polypeptide binding]; other site 692420004022 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420004023 BNR repeat-like domain; Region: BNR_2; pfam13088 692420004024 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420004025 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 692420004026 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 692420004027 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 692420004028 active site 692420004029 trimer interface [polypeptide binding]; other site 692420004030 substrate binding site [chemical binding]; other site 692420004031 CoA binding site [chemical binding]; other site 692420004032 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420004033 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 692420004034 metal binding site [ion binding]; metal-binding site 692420004035 putative dimer interface [polypeptide binding]; other site 692420004036 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 692420004037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420004038 potential frameshift: common BLAST hit: gi|154685832|ref|YP_001420993.1| YkuV 692420004039 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 692420004040 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 692420004041 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 692420004042 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 692420004043 GTP binding site; other site 692420004044 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 692420004045 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420004046 ATP binding site [chemical binding]; other site 692420004047 substrate interface [chemical binding]; other site 692420004048 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 692420004049 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 692420004050 dimer interface [polypeptide binding]; other site 692420004051 putative functional site; other site 692420004052 putative MPT binding site; other site 692420004053 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 692420004054 Walker A motif; other site 692420004055 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 692420004056 MoaE homodimer interface [polypeptide binding]; other site 692420004057 MoaD interaction [polypeptide binding]; other site 692420004058 active site residues [active] 692420004059 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 692420004060 MoaE interaction surface [polypeptide binding]; other site 692420004061 MoeB interaction surface [polypeptide binding]; other site 692420004062 thiocarboxylated glycine; other site 692420004063 Yip1 domain; Region: Yip1; cl12048 692420004064 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 692420004065 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 692420004066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420004067 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 692420004068 Walker A/P-loop; other site 692420004069 ATP binding site [chemical binding]; other site 692420004070 Q-loop/lid; other site 692420004071 ABC transporter signature motif; other site 692420004072 Walker B; other site 692420004073 D-loop; other site 692420004074 H-loop/switch region; other site 692420004075 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420004076 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420004077 FtsX-like permease family; Region: FtsX; cl15850 692420004078 Helix-turn-helix domains; Region: HTH; cl00088 692420004079 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420004080 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 692420004081 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 692420004082 putative substrate binding site [chemical binding]; other site 692420004083 putative ATP binding site [chemical binding]; other site 692420004084 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 692420004085 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420004086 active site 692420004087 phosphorylation site [posttranslational modification] 692420004088 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 692420004089 P-loop; other site 692420004090 active site 692420004091 phosphorylation site [posttranslational modification] 692420004092 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420004093 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420004094 Catalytic site [active] 692420004095 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 692420004096 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420004097 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420004098 ABC transporter; Region: ABC_tran_2; pfam12848 692420004099 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 692420004100 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 692420004101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004102 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 692420004103 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 692420004104 rod-share determining protein MreBH; Provisional; Region: PRK13929 692420004105 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 692420004106 ATP binding site [chemical binding]; other site 692420004107 profilin binding site; other site 692420004108 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 692420004109 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 692420004110 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 692420004111 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 692420004112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004113 putative active site [active] 692420004114 heme pocket [chemical binding]; other site 692420004115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 692420004116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004117 ATP binding site [chemical binding]; other site 692420004118 Mg2+ binding site [ion binding]; other site 692420004119 G-X-G motif; other site 692420004120 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 692420004121 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 692420004122 putative active site pocket [active] 692420004123 dimerization interface [polypeptide binding]; other site 692420004124 putative catalytic residue [active] 692420004125 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 692420004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004127 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 692420004128 adenine deaminase; Region: ade; TIGR01178 692420004129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420004130 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 692420004131 active site 692420004132 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420004133 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 692420004134 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420004135 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 692420004136 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 692420004137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420004138 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420004139 active site 692420004140 motif I; other site 692420004141 motif II; other site 692420004142 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420004143 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 692420004144 active site 692420004145 catalytic residues [active] 692420004146 metal binding site [ion binding]; metal-binding site 692420004147 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 692420004148 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 692420004149 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420004150 TPP-binding site [chemical binding]; other site 692420004151 tetramer interface [polypeptide binding]; other site 692420004152 heterodimer interface [polypeptide binding]; other site 692420004153 phosphorylation loop region [posttranslational modification] 692420004154 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420004155 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420004156 alpha subunit interface [polypeptide binding]; other site 692420004157 TPP binding site [chemical binding]; other site 692420004158 heterodimer interface [polypeptide binding]; other site 692420004159 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420004160 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420004161 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420004162 E3 interaction surface; other site 692420004163 lipoyl attachment site [posttranslational modification]; other site 692420004164 e3 binding domain; Region: E3_binding; pfam02817 692420004165 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 692420004166 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 692420004167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420004169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420004170 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 692420004171 NodB motif; other site 692420004172 active site 692420004173 catalytic site [active] 692420004174 metal binding site [ion binding]; metal-binding site 692420004175 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 692420004176 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 692420004177 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 692420004178 homodimer interface [polypeptide binding]; other site 692420004179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420004180 catalytic residue [active] 692420004181 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 692420004182 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 692420004183 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 692420004184 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 692420004185 active site 692420004186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420004187 Coenzyme A binding pocket [chemical binding]; other site 692420004188 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 692420004189 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 692420004190 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420004191 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 692420004192 active site 692420004193 Zn binding site [ion binding]; other site 692420004194 Putative zinc-finger; Region: zf-HC2; cl15806 692420004195 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 692420004196 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 692420004197 G1 box; other site 692420004198 putative GEF interaction site [polypeptide binding]; other site 692420004199 GTP/Mg2+ binding site [chemical binding]; other site 692420004200 Switch I region; other site 692420004201 G2 box; other site 692420004202 G3 box; other site 692420004203 Switch II region; other site 692420004204 G4 box; other site 692420004205 G5 box; other site 692420004206 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 692420004207 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 692420004208 YlaH-like protein; Region: YlaH; pfam14036 692420004209 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 692420004210 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 692420004211 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420004212 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 692420004213 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 692420004214 putative active site [active] 692420004215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420004216 Glutaminase; Region: Glutaminase; cl00907 692420004217 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 692420004218 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 692420004219 pyruvate carboxylase; Reviewed; Region: PRK12999 692420004220 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004221 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420004222 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 692420004223 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 692420004224 active site 692420004225 catalytic residues [active] 692420004226 metal binding site [ion binding]; metal-binding site 692420004227 homodimer binding site [polypeptide binding]; other site 692420004228 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420004229 carboxyltransferase (CT) interaction site; other site 692420004230 biotinylation site [posttranslational modification]; other site 692420004231 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 692420004232 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 692420004233 UbiA prenyltransferase family; Region: UbiA; cl00337 692420004234 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 692420004235 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 692420004236 Cytochrome c; Region: Cytochrom_C; cl11414 692420004237 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 692420004238 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 692420004239 D-pathway; other site 692420004240 Putative ubiquinol binding site [chemical binding]; other site 692420004241 Low-spin heme (heme b) binding site [chemical binding]; other site 692420004242 Putative water exit pathway; other site 692420004243 Binuclear center (heme o3/CuB) [ion binding]; other site 692420004244 K-pathway; other site 692420004245 Putative proton exit pathway; other site 692420004246 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 692420004247 Subunit I/III interface [polypeptide binding]; other site 692420004248 Subunit III/IV interface [polypeptide binding]; other site 692420004249 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 692420004250 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 692420004251 YugN-like family; Region: YugN; pfam08868 692420004252 FOG: CBS domain [General function prediction only]; Region: COG0517 692420004253 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 692420004254 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 692420004255 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 692420004256 Putative coat protein; Region: YlbD_coat; pfam14071 692420004257 YlbE-like protein; Region: YlbE; pfam14003 692420004258 Protein of unknown function (DUF964); Region: DUF964; cl01483 692420004259 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 692420004260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420004261 S-adenosylmethionine binding site [chemical binding]; other site 692420004262 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 692420004263 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 692420004264 active site 692420004265 (T/H)XGH motif; other site 692420004266 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 692420004267 Nucleoside recognition; Region: Gate; cl00486 692420004268 Nucleoside recognition; Region: Gate; cl00486 692420004269 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 692420004270 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 692420004271 active site 692420004272 nucleophile elbow; other site 692420004273 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 692420004274 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 692420004275 protein binding site [polypeptide binding]; other site 692420004276 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 692420004277 hypothetical protein; Provisional; Region: PRK13670 692420004278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 692420004279 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 692420004280 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 692420004281 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 692420004282 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 692420004283 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420004284 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 692420004285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004286 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 692420004287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 692420004288 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 692420004289 mraZ protein; Region: TIGR00242 692420004290 MraZ protein; Region: MraZ; pfam02381 692420004291 MraZ protein; Region: MraZ; pfam02381 692420004292 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 692420004293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004294 Septum formation initiator; Region: DivIC; cl11433 692420004295 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420004296 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420004298 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 692420004299 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 692420004300 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 692420004301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420004303 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 692420004304 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 692420004305 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420004306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420004307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420004308 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 692420004309 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 692420004310 Mg++ binding site [ion binding]; other site 692420004311 putative catalytic motif [active] 692420004312 putative substrate binding site [chemical binding]; other site 692420004313 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 692420004314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420004315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420004316 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 692420004317 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 692420004318 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 692420004319 active site 692420004320 homodimer interface [polypeptide binding]; other site 692420004321 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 692420004322 FAD binding domain; Region: FAD_binding_4; pfam01565 692420004323 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 692420004324 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 692420004325 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 692420004326 Cell division protein FtsQ; Region: FtsQ; pfam03799 692420004327 cell division protein FtsA; Region: ftsA; TIGR01174 692420004328 Cell division protein FtsA; Region: FtsA; cl11496 692420004329 Cell division protein FtsA; Region: FtsA; cl11496 692420004330 cell division protein FtsZ; Validated; Region: PRK09330 692420004331 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 692420004332 nucleotide binding site [chemical binding]; other site 692420004333 SulA interaction site; other site 692420004334 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420004335 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 692420004336 active site 692420004337 catalytic triad [active] 692420004338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 692420004339 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 692420004340 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420004341 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 692420004342 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 692420004343 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 692420004344 sporulation sigma factor SigE; Reviewed; Region: PRK08301 692420004345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420004347 DNA binding residues [nucleotide binding] 692420004348 sporulation sigma factor SigG; Reviewed; Region: PRK08215 692420004349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004350 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420004351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420004352 DNA binding residues [nucleotide binding] 692420004353 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420004354 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 692420004355 Walker A/P-loop; other site 692420004356 ATP binding site [chemical binding]; other site 692420004357 Q-loop/lid; other site 692420004358 ABC transporter signature motif; other site 692420004359 Walker B; other site 692420004360 D-loop; other site 692420004361 H-loop/switch region; other site 692420004362 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 692420004363 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 692420004364 metal binding site [ion binding]; metal-binding site 692420004365 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 692420004366 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 692420004367 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 692420004368 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 692420004369 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420004370 catalytic residue [active] 692420004371 Protein of unknown function (DUF552); Region: DUF552; cl00775 692420004372 YGGT family; Region: YGGT; cl00508 692420004373 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 692420004374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420004375 RNA binding surface [nucleotide binding]; other site 692420004376 DivIVA protein; Region: DivIVA; pfam05103 692420004377 DivIVA domain; Region: DivI1A_domain; TIGR03544 692420004378 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 692420004379 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 692420004380 HIGH motif; other site 692420004381 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420004382 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 692420004383 active site 692420004384 KMSKS motif; other site 692420004385 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 692420004386 tRNA binding surface [nucleotide binding]; other site 692420004387 anticodon binding site; other site 692420004388 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 692420004389 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 692420004390 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 692420004391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420004392 RNA binding surface [nucleotide binding]; other site 692420004393 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 692420004394 active site 692420004395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420004396 active site 692420004397 uracil-xanthine permease; Region: ncs2; TIGR00801 692420004398 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 692420004399 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 692420004400 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 692420004401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004402 dihydroorotase; Validated; Region: pyrC; PRK09357 692420004403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420004404 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 692420004405 active site 692420004406 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 692420004407 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 692420004408 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 692420004409 catalytic site [active] 692420004410 subunit interface [polypeptide binding]; other site 692420004411 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 692420004412 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004413 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420004414 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 692420004415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004416 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420004417 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 692420004418 IMP binding site; other site 692420004419 dimer interface [polypeptide binding]; other site 692420004420 interdomain contacts; other site 692420004421 partial ornithine binding site; other site 692420004422 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 692420004423 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 692420004424 FAD binding pocket [chemical binding]; other site 692420004425 FAD binding motif [chemical binding]; other site 692420004426 phosphate binding motif [ion binding]; other site 692420004427 beta-alpha-beta structure motif; other site 692420004428 NAD binding pocket [chemical binding]; other site 692420004429 Iron coordination center [ion binding]; other site 692420004430 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 692420004431 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 692420004432 heterodimer interface [polypeptide binding]; other site 692420004433 active site 692420004434 FMN binding site [chemical binding]; other site 692420004435 homodimer interface [polypeptide binding]; other site 692420004436 substrate binding site [chemical binding]; other site 692420004437 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 692420004438 active site 692420004439 dimer interface [polypeptide binding]; other site 692420004440 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 692420004441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420004442 active site 692420004443 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 692420004444 Active Sites [active] 692420004445 Phosphate transporter family; Region: PHO4; cl00396 692420004446 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 692420004447 ATP-sulfurylase; Region: ATPS; cd00517 692420004448 active site 692420004449 HXXH motif; other site 692420004450 flexible loop; other site 692420004451 AAA domain; Region: AAA_33; pfam13671 692420004452 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 692420004453 ligand-binding site [chemical binding]; other site 692420004454 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 692420004455 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 692420004456 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 692420004457 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 692420004458 putative active site [active] 692420004459 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 692420004460 putative active site [active] 692420004461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004462 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 692420004463 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 692420004464 active site 692420004465 Na/Ca binding site [ion binding]; other site 692420004466 catalytic site [active] 692420004467 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 692420004468 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 692420004469 Domain of unknown function (DUF814); Region: DUF814; pfam05670 692420004470 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 692420004471 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 692420004472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420004473 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 692420004474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420004475 motif II; other site 692420004476 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 692420004477 TIGR00255 family protein; Region: TIGR00255 692420004478 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 692420004479 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 692420004480 Domain of unknown function (DUF370); Region: DUF370; cl00898 692420004481 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 692420004482 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 692420004483 catalytic site [active] 692420004484 G-X2-G-X-G-K; other site 692420004485 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 692420004486 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 692420004487 Flavoprotein; Region: Flavoprotein; cl08021 692420004488 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 692420004489 primosome assembly protein PriA; Validated; Region: PRK05580 692420004490 primosome assembly protein PriA; Validated; Region: PRK05580 692420004491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420004492 ATP binding site [chemical binding]; other site 692420004493 putative Mg++ binding site [ion binding]; other site 692420004494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420004495 nucleotide binding region [chemical binding]; other site 692420004496 ATP-binding site [chemical binding]; other site 692420004497 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 692420004498 active site 692420004499 catalytic residues [active] 692420004500 metal binding site [ion binding]; metal-binding site 692420004501 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 692420004502 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 692420004503 putative active site [active] 692420004504 substrate binding site [chemical binding]; other site 692420004505 putative cosubstrate binding site; other site 692420004506 catalytic site [active] 692420004507 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 692420004508 substrate binding site [chemical binding]; other site 692420004509 16S rRNA methyltransferase B; Provisional; Region: PRK14902 692420004510 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 692420004511 putative RNA binding site [nucleotide binding]; other site 692420004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420004513 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 692420004514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420004515 FeS/SAM binding site; other site 692420004516 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 692420004517 Protein phosphatase 2C; Region: PP2C; pfam00481 692420004518 active site 692420004519 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 692420004520 Catalytic domain of Protein Kinases; Region: PKc; cd00180 692420004521 active site 692420004522 ATP binding site [chemical binding]; other site 692420004523 substrate binding site [chemical binding]; other site 692420004524 activation loop (A-loop); other site 692420004525 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420004526 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 692420004527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 692420004528 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004529 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004530 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004531 GTPase RsgA; Reviewed; Region: PRK00098 692420004532 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 692420004533 RNA binding site [nucleotide binding]; other site 692420004534 homodimer interface [polypeptide binding]; other site 692420004535 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 692420004536 GTPase/Zn-binding domain interface [polypeptide binding]; other site 692420004537 GTP/Mg2+ binding site [chemical binding]; other site 692420004538 G4 box; other site 692420004539 G5 box; other site 692420004540 G1 box; other site 692420004541 Switch I region; other site 692420004542 G2 box; other site 692420004543 G3 box; other site 692420004544 Switch II region; other site 692420004545 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 692420004546 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 692420004547 substrate binding site [chemical binding]; other site 692420004548 hexamer interface [polypeptide binding]; other site 692420004549 metal binding site [ion binding]; metal-binding site 692420004550 Thiamine pyrophosphokinase; Region: TPK; cd07995 692420004551 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 692420004552 active site 692420004553 dimerization interface [polypeptide binding]; other site 692420004554 thiamine binding site [chemical binding]; other site 692420004555 Stage V sporulation protein family; Region: SpoV; cl15455 692420004556 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 692420004557 Asp23 family; Region: Asp23; cl00574 692420004558 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 692420004559 DAK2 domain; Region: Dak2; cl03685 692420004560 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 692420004561 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 692420004562 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 692420004563 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 692420004564 putative L-serine binding site [chemical binding]; other site 692420004565 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 692420004566 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 692420004567 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 692420004568 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 692420004569 generic binding surface II; other site 692420004570 ssDNA binding site; other site 692420004571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420004572 ATP binding site [chemical binding]; other site 692420004573 putative Mg++ binding site [ion binding]; other site 692420004574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420004575 nucleotide binding region [chemical binding]; other site 692420004576 ATP-binding site [chemical binding]; other site 692420004577 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 692420004578 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 692420004579 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 692420004580 Acyl transferase domain; Region: Acyl_transf_1; cl08282 692420004581 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420004582 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 692420004583 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 692420004584 NAD(P) binding site [chemical binding]; other site 692420004585 homotetramer interface [polypeptide binding]; other site 692420004586 homodimer interface [polypeptide binding]; other site 692420004587 active site 692420004588 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420004589 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 692420004590 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 692420004591 dimerization interface [polypeptide binding]; other site 692420004592 active site 692420004593 metal binding site [ion binding]; metal-binding site 692420004594 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 692420004595 dsRNA binding site [nucleotide binding]; other site 692420004596 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 692420004597 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 692420004598 Walker A/P-loop; other site 692420004599 ATP binding site [chemical binding]; other site 692420004600 Q-loop/lid; other site 692420004601 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 692420004602 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 692420004603 Q-loop/lid; other site 692420004604 ABC transporter signature motif; other site 692420004605 Walker B; other site 692420004606 D-loop; other site 692420004607 H-loop/switch region; other site 692420004608 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 692420004609 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 692420004610 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 692420004611 GTP binding site [chemical binding]; other site 692420004612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420004613 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 692420004614 signal recognition particle protein; Provisional; Region: PRK10867 692420004615 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 692420004616 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 692420004617 P loop; other site 692420004618 GTP binding site [chemical binding]; other site 692420004619 Signal peptide binding domain; Region: SRP_SPB; pfam02978 692420004620 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 692420004621 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 692420004622 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 692420004623 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 692420004624 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 692420004625 RimM N-terminal domain; Region: RimM; pfam01782 692420004626 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 692420004627 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 692420004628 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 692420004629 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 692420004630 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 692420004631 GTP/Mg2+ binding site [chemical binding]; other site 692420004632 G4 box; other site 692420004633 G5 box; other site 692420004634 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 692420004635 G1 box; other site 692420004636 G1 box; other site 692420004637 GTP/Mg2+ binding site [chemical binding]; other site 692420004638 Switch I region; other site 692420004639 G2 box; other site 692420004640 G2 box; other site 692420004641 G3 box; other site 692420004642 G3 box; other site 692420004643 Switch II region; other site 692420004644 Switch II region; other site 692420004645 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 692420004646 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420004647 active site 692420004648 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 692420004649 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 692420004650 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420004651 CoA-ligase; Region: Ligase_CoA; cl02894 692420004652 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 692420004653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004654 CoA-ligase; Region: Ligase_CoA; cl02894 692420004655 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 692420004656 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 692420004657 DNA topoisomerase I; Validated; Region: PRK05582 692420004658 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 692420004659 active site 692420004660 interdomain interaction site; other site 692420004661 putative metal-binding site [ion binding]; other site 692420004662 nucleotide binding site [chemical binding]; other site 692420004663 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 692420004664 domain I; other site 692420004665 DNA binding groove [nucleotide binding] 692420004666 phosphate binding site [ion binding]; other site 692420004667 domain II; other site 692420004668 domain III; other site 692420004669 nucleotide binding site [chemical binding]; other site 692420004670 catalytic site [active] 692420004671 domain IV; other site 692420004672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 692420004673 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 692420004674 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 692420004675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004676 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 692420004677 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 692420004678 Int/Topo IB signature motif; other site 692420004679 active site 692420004680 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 692420004681 active site 692420004682 HslU subunit interaction site [polypeptide binding]; other site 692420004683 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 692420004684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420004685 Walker A motif; other site 692420004686 ATP binding site [chemical binding]; other site 692420004687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420004688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 692420004689 transcriptional repressor CodY; Validated; Region: PRK04158 692420004690 CodY GAF-like domain; Region: CodY; pfam06018 692420004691 Helix-turn-helix domains; Region: HTH; cl00088 692420004692 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 692420004693 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420004694 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 692420004695 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420004696 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 692420004697 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 692420004698 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 692420004699 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 692420004700 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 692420004701 flagellar motor switch protein FliG; Region: fliG; TIGR00207 692420004702 MgtE intracellular N domain; Region: MgtE_N; cl15244 692420004703 FliG C-terminal domain; Region: FliG_C; pfam01706 692420004704 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 692420004705 Flagellar assembly protein FliH; Region: FliH; pfam02108 692420004706 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 692420004707 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 692420004708 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 692420004709 Walker A motif/ATP binding site; other site 692420004710 Walker B motif; other site 692420004711 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 692420004712 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 692420004713 MgtE intracellular N domain; Region: MgtE_N; cl15244 692420004714 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 692420004715 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 692420004716 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 692420004717 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 692420004718 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 692420004719 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420004720 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420004721 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 692420004722 Flagellar protein (FlbD); Region: FlbD; cl00683 692420004723 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 692420004724 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 692420004725 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 692420004726 flagellar motor switch protein; Validated; Region: PRK08119 692420004727 Chemotaxis phosphatase CheX; Region: CheX; cl15816 692420004728 Chemotaxis phosphatase CheX; Region: CheX; cl15816 692420004729 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 692420004730 Response regulator receiver domain; Region: Response_reg; pfam00072 692420004731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420004732 active site 692420004733 phosphorylation site [posttranslational modification] 692420004734 intermolecular recognition site; other site 692420004735 dimerization interface [polypeptide binding]; other site 692420004736 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 692420004737 FliP family; Region: FliP; cl00593 692420004738 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 692420004739 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 692420004740 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 692420004741 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 692420004742 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 692420004743 FHIPEP family; Region: FHIPEP; pfam00771 692420004744 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 692420004745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420004746 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 692420004747 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 692420004748 P-loop; other site 692420004749 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 692420004750 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 692420004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420004752 active site 692420004753 phosphorylation site [posttranslational modification] 692420004754 intermolecular recognition site; other site 692420004755 dimerization interface [polypeptide binding]; other site 692420004756 CheB methylesterase; Region: CheB_methylest; pfam01339 692420004757 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 692420004758 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 692420004759 putative binding surface; other site 692420004760 active site 692420004761 P2 response regulator binding domain; Region: P2; pfam07194 692420004762 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 692420004763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004764 ATP binding site [chemical binding]; other site 692420004765 Mg2+ binding site [ion binding]; other site 692420004766 G-X-G motif; other site 692420004767 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 692420004768 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 692420004769 putative CheA interaction surface; other site 692420004770 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 692420004771 Chemotaxis phosphatase CheX; Region: CheX; cl15816 692420004772 Chemotaxis phosphatase CheX; Region: CheX; cl15816 692420004773 CheD chemotactic sensory transduction; Region: CheD; cl00810 692420004774 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 692420004775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004776 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420004777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420004778 DNA binding residues [nucleotide binding] 692420004779 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 692420004780 rRNA interaction site [nucleotide binding]; other site 692420004781 S8 interaction site; other site 692420004782 putative laminin-1 binding site; other site 692420004783 elongation factor Ts; Provisional; Region: tsf; PRK09377 692420004784 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 692420004785 Elongation factor TS; Region: EF_TS; pfam00889 692420004786 Elongation factor TS; Region: EF_TS; pfam00889 692420004787 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 692420004788 putative nucleotide binding site [chemical binding]; other site 692420004789 uridine monophosphate binding site [chemical binding]; other site 692420004790 homohexameric interface [polypeptide binding]; other site 692420004791 ribosome recycling factor; Reviewed; Region: frr; PRK00083 692420004792 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 692420004793 hinge region; other site 692420004794 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 692420004795 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 692420004796 catalytic residue [active] 692420004797 putative FPP diphosphate binding site; other site 692420004798 putative FPP binding hydrophobic cleft; other site 692420004799 dimer interface [polypeptide binding]; other site 692420004800 putative IPP diphosphate binding site; other site 692420004801 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 692420004802 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 692420004803 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 692420004804 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 692420004805 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 692420004806 RIP metalloprotease RseP; Region: TIGR00054 692420004807 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 692420004808 active site 692420004809 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 692420004810 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 692420004811 protein binding site [polypeptide binding]; other site 692420004812 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 692420004813 putative substrate binding region [chemical binding]; other site 692420004814 prolyl-tRNA synthetase; Provisional; Region: PRK09194 692420004815 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 692420004816 dimer interface [polypeptide binding]; other site 692420004817 motif 1; other site 692420004818 active site 692420004819 motif 2; other site 692420004820 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 692420004821 putative deacylase active site [active] 692420004822 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 692420004823 active site 692420004824 motif 3; other site 692420004825 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 692420004826 anticodon binding site; other site 692420004827 DNA polymerase III PolC; Validated; Region: polC; PRK00448 692420004828 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 692420004829 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 692420004830 generic binding surface II; other site 692420004831 generic binding surface I; other site 692420004832 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 692420004833 active site 692420004834 substrate binding site [chemical binding]; other site 692420004835 catalytic site [active] 692420004836 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 692420004837 ribosome maturation protein RimP; Reviewed; Region: PRK00092 692420004838 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 692420004839 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 692420004840 Sm1 motif; other site 692420004841 predicted subunit interaction site [polypeptide binding]; other site 692420004842 RNA binding pocket [nucleotide binding]; other site 692420004843 Sm2 motif; other site 692420004844 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 692420004845 NusA N-terminal domain; Region: NusA_N; pfam08529 692420004846 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 692420004847 RNA binding site [nucleotide binding]; other site 692420004848 homodimer interface [polypeptide binding]; other site 692420004849 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 692420004850 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 692420004851 G-X-X-G motif; other site 692420004852 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 692420004853 putative RNA binding cleft [nucleotide binding]; other site 692420004854 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 692420004855 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 692420004856 translation initiation factor IF-2; Region: IF-2; TIGR00487 692420004857 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 692420004858 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 692420004859 G1 box; other site 692420004860 putative GEF interaction site [polypeptide binding]; other site 692420004861 GTP/Mg2+ binding site [chemical binding]; other site 692420004862 Switch I region; other site 692420004863 G2 box; other site 692420004864 G3 box; other site 692420004865 Switch II region; other site 692420004866 G4 box; other site 692420004867 G5 box; other site 692420004868 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 692420004869 Translation-initiation factor 2; Region: IF-2; pfam11987 692420004870 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 692420004871 Protein of unknown function (DUF503); Region: DUF503; cl00669 692420004872 Ribosome-binding factor A; Region: RBFA; cl00542 692420004873 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 692420004874 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 692420004875 RNA binding site [nucleotide binding]; other site 692420004876 active site 692420004877 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 692420004878 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 692420004879 active site 692420004880 Riboflavin kinase; Region: Flavokinase; cl03312 692420004881 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 692420004882 16S/18S rRNA binding site [nucleotide binding]; other site 692420004883 S13e-L30e interaction site [polypeptide binding]; other site 692420004884 25S rRNA binding site [nucleotide binding]; other site 692420004885 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 692420004886 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 692420004887 RNase E interface [polypeptide binding]; other site 692420004888 trimer interface [polypeptide binding]; other site 692420004889 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 692420004890 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 692420004891 RNase E interface [polypeptide binding]; other site 692420004892 trimer interface [polypeptide binding]; other site 692420004893 active site 692420004894 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 692420004895 putative nucleic acid binding region [nucleotide binding]; other site 692420004896 G-X-X-G motif; other site 692420004897 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 692420004898 RNA binding site [nucleotide binding]; other site 692420004899 domain interface; other site 692420004900 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 692420004901 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 692420004902 NodB motif; other site 692420004903 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420004904 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 692420004905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420004906 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 692420004907 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 692420004908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004909 Flavoprotein; Region: Flavoprotein; cl08021 692420004910 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 692420004911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420004912 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 692420004913 aspartate kinase I; Reviewed; Region: PRK08210 692420004914 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 692420004915 putative catalytic residues [active] 692420004916 putative nucleotide binding site [chemical binding]; other site 692420004917 putative aspartate binding site [chemical binding]; other site 692420004918 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 692420004919 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 692420004920 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 692420004921 dihydrodipicolinate synthase; Region: dapA; TIGR00674 692420004922 dimer interface [polypeptide binding]; other site 692420004923 active site 692420004924 catalytic residue [active] 692420004925 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 692420004926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420004927 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 692420004928 Clp protease; Region: CLP_protease; pfam00574 692420004929 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 692420004930 active site 692420004931 YlzJ-like protein; Region: YlzJ; pfam14035 692420004932 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 692420004933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420004934 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 692420004935 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420004936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420004937 DNA-binding site [nucleotide binding]; DNA binding site 692420004938 UTRA domain; Region: UTRA; cl01230 692420004939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420004940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420004941 putative substrate translocation pore; other site 692420004942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420004943 Helix-turn-helix domains; Region: HTH; cl00088 692420004944 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 692420004945 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 692420004946 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 692420004947 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420004948 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420004949 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420004950 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 692420004951 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420004952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 692420004953 classical (c) SDRs; Region: SDR_c; cd05233 692420004954 NAD(P) binding site [chemical binding]; other site 692420004955 active site 692420004956 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 692420004957 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 692420004958 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 692420004959 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 692420004960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420004961 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 692420004962 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 692420004963 competence damage-inducible protein A; Provisional; Region: PRK00549 692420004964 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 692420004965 putative MPT binding site; other site 692420004966 Competence-damaged protein; Region: CinA; cl00666 692420004967 recombinase A; Provisional; Region: recA; PRK09354 692420004968 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 692420004969 hexamer interface [polypeptide binding]; other site 692420004970 Walker A motif; other site 692420004971 ATP binding site [chemical binding]; other site 692420004972 Walker B motif; other site 692420004973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420004974 phosphodiesterase; Provisional; Region: PRK12704 692420004975 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 692420004976 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 692420004977 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420004978 putative active site [active] 692420004979 metal binding site [ion binding]; metal-binding site 692420004980 homodimer binding site [polypeptide binding]; other site 692420004981 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 692420004982 Threonine dehydrogenase; Region: TDH; cd05281 692420004983 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 692420004984 structural Zn binding site [ion binding]; other site 692420004985 catalytic Zn binding site [ion binding]; other site 692420004986 tetramer interface [polypeptide binding]; other site 692420004987 NADP binding site [chemical binding]; other site 692420004988 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 692420004989 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 692420004990 substrate-cofactor binding pocket; other site 692420004991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420004992 catalytic residue [active] 692420004993 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 692420004994 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 692420004995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420004996 FeS/SAM binding site; other site 692420004997 TRAM domain; Region: TRAM; cl01282 692420004998 Protein of unknown function (DUF964); Region: DUF964; cl01483 692420004999 Outer spore coat protein E (CotE); Region: CotE; pfam10628 692420005000 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 692420005001 MutS domain I; Region: MutS_I; pfam01624 692420005002 MutS domain II; Region: MutS_II; pfam05188 692420005003 MutS family domain IV; Region: MutS_IV; pfam05190 692420005004 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 692420005005 Walker A/P-loop; other site 692420005006 ATP binding site [chemical binding]; other site 692420005007 Q-loop/lid; other site 692420005008 ABC transporter signature motif; other site 692420005009 Walker B; other site 692420005010 D-loop; other site 692420005011 H-loop/switch region; other site 692420005012 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 692420005013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005014 ATP binding site [chemical binding]; other site 692420005015 Mg2+ binding site [ion binding]; other site 692420005016 G-X-G motif; other site 692420005017 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 692420005018 ATP binding site [chemical binding]; other site 692420005019 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 692420005020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420005021 Acyl transferase domain; Region: Acyl_transf_1; cl08282 692420005022 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005023 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005024 Acyl transferase domain; Region: Acyl_transf_1; cl08282 692420005025 Acyl transferase domain; Region: Acyl_transf_1; cl08282 692420005026 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005027 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 692420005028 FMN binding site [chemical binding]; other site 692420005029 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 692420005030 substrate binding site [chemical binding]; other site 692420005031 putative catalytic residue [active] 692420005032 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005033 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 692420005034 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 692420005035 dimer interface [polypeptide binding]; other site 692420005036 active site 692420005037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005038 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420005039 substrate binding site [chemical binding]; other site 692420005040 oxyanion hole (OAH) forming residues; other site 692420005041 trimer interface [polypeptide binding]; other site 692420005042 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420005043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005044 substrate binding site [chemical binding]; other site 692420005045 oxyanion hole (OAH) forming residues; other site 692420005046 trimer interface [polypeptide binding]; other site 692420005047 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420005048 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005049 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005050 Condensation domain; Region: Condensation; pfam00668 692420005051 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005052 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005053 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005054 acyl-CoA synthetase; Validated; Region: PRK08308 692420005055 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005056 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005057 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005058 active site 692420005059 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005060 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005061 putative NADP binding site [chemical binding]; other site 692420005062 active site 692420005063 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005064 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005065 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005066 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005067 active site 692420005068 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005069 putative NADP binding site [chemical binding]; other site 692420005070 active site 692420005071 peptide synthase; Provisional; Region: PRK12316 692420005072 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005073 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005074 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005075 active site 692420005076 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005077 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005078 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005079 active site 692420005080 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005081 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005082 putative NADP binding site [chemical binding]; other site 692420005083 active site 692420005084 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005085 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005086 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005087 active site 692420005088 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005090 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005091 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005092 active site 692420005093 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005094 putative NADP binding site [chemical binding]; other site 692420005095 active site 692420005096 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005097 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005098 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005099 active site 692420005100 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005101 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005102 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005103 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005104 active site 692420005105 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005106 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005107 putative NADP binding site [chemical binding]; other site 692420005108 active site 692420005109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005110 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005111 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005112 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005113 active site 692420005114 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005115 putative NADP binding site [chemical binding]; other site 692420005116 active site 692420005117 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005118 Condensation domain; Region: Condensation; pfam00668 692420005119 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005120 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005121 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005122 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005123 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005124 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005125 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005126 active site 692420005127 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005128 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005129 putative NADP binding site [chemical binding]; other site 692420005130 active site 692420005131 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005132 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005133 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005134 active site 692420005135 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005136 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005137 putative NADP binding site [chemical binding]; other site 692420005138 active site 692420005139 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005140 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005141 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005142 active site 692420005143 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005144 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005145 putative NADP binding site [chemical binding]; other site 692420005146 active site 692420005147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005148 S-adenosylmethionine binding site [chemical binding]; other site 692420005149 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005151 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005152 active site 692420005153 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005154 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 692420005155 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005156 active site 692420005157 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005158 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005159 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 692420005160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420005161 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 692420005162 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 692420005163 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 692420005164 active site 692420005165 catalytic triad [active] 692420005166 Protein of unknown function (DUF867); Region: DUF867; cl01713 692420005167 OsmC-like protein; Region: OsmC; cl00767 692420005168 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420005169 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 692420005170 YmaF family; Region: YmaF; pfam12788 692420005171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005172 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 692420005173 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 692420005174 Sm1 motif; other site 692420005175 intra - hexamer interaction site; other site 692420005176 inter - hexamer interaction site [polypeptide binding]; other site 692420005177 nucleotide binding pocket [chemical binding]; other site 692420005178 Sm2 motif; other site 692420005179 YmzC-like protein; Region: YmzC; pfam14157 692420005180 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420005181 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 692420005182 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 692420005183 Class I ribonucleotide reductase; Region: RNR_I; cd01679 692420005184 active site 692420005185 dimer interface [polypeptide binding]; other site 692420005186 catalytic residues [active] 692420005187 effector binding site; other site 692420005188 R2 peptide binding site; other site 692420005189 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 692420005190 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 692420005191 dimer interface [polypeptide binding]; other site 692420005192 putative radical transfer pathway; other site 692420005193 diiron center [ion binding]; other site 692420005194 tyrosyl radical; other site 692420005195 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 692420005196 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420005197 active site 692420005198 metal binding site [ion binding]; metal-binding site 692420005199 Sporulation related domain; Region: SPOR; cl10051 692420005200 stage V sporulation protein K; Region: spore_V_K; TIGR02881 692420005201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420005202 Walker A motif; other site 692420005203 ATP binding site [chemical binding]; other site 692420005204 Walker B motif; other site 692420005205 arginine finger; other site 692420005206 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 692420005207 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 692420005208 HflX GTPase family; Region: HflX; cd01878 692420005209 G1 box; other site 692420005210 GTP/Mg2+ binding site [chemical binding]; other site 692420005211 Switch I region; other site 692420005212 G2 box; other site 692420005213 G3 box; other site 692420005214 Switch II region; other site 692420005215 G4 box; other site 692420005216 G5 box; other site 692420005217 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 692420005218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420005219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420005220 catalytic residue [active] 692420005221 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 692420005222 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420005223 DNA binding residues [nucleotide binding] 692420005224 putative dimer interface [polypeptide binding]; other site 692420005225 glutamine synthetase, type I; Region: GlnA; TIGR00653 692420005226 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 692420005227 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 692420005228 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 692420005229 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420005230 Int/Topo IB signature motif; other site 692420005231 Staphylococcal nuclease homologues; Region: SNc; smart00318 692420005232 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 692420005233 Catalytic site; other site 692420005234 Excalibur calcium-binding domain; Region: Excalibur; cl05460 692420005235 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 692420005236 Uncharacterized conserved protein [Function unknown]; Region: COG5444 692420005237 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 692420005238 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 692420005239 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 692420005240 YolD-like protein; Region: YolD; pfam08863 692420005241 DNA polymerase IV; Reviewed; Region: PRK03103 692420005242 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 692420005243 active site 692420005244 DNA binding site [nucleotide binding] 692420005245 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420005246 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420005247 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 692420005248 ATP binding site [chemical binding]; other site 692420005249 substrate interface [chemical binding]; other site 692420005250 tellurite resistance protein TehB; Provisional; Region: PRK11207 692420005251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005252 S-adenosylmethionine binding site [chemical binding]; other site 692420005253 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 692420005254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005255 S-adenosylmethionine binding site [chemical binding]; other site 692420005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005257 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420005258 putative substrate translocation pore; other site 692420005259 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 692420005260 N- and C-terminal domain interface [polypeptide binding]; other site 692420005261 active site 692420005262 metal binding site [ion binding]; metal-binding site 692420005263 putative ATP binding site [chemical binding]; other site 692420005264 homodimer interface [polypeptide binding]; other site 692420005265 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 692420005266 phosphoenolpyruvate synthase; Validated; Region: PRK06241 692420005267 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 692420005268 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 692420005269 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 692420005270 Helix-turn-helix domains; Region: HTH; cl00088 692420005271 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420005272 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 692420005273 putative NAD(P) binding site [chemical binding]; other site 692420005274 catalytic Zn binding site [ion binding]; other site 692420005275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420005276 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420005277 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420005278 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005279 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420005280 catalytic residues [active] 692420005281 catalytic nucleophile [active] 692420005282 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420005283 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420005284 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420005285 Synaptic Site I dimer interface [polypeptide binding]; other site 692420005286 DNA binding site [nucleotide binding] 692420005287 Helix-turn-helix domains; Region: HTH; cl00088 692420005288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420005289 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005290 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420005291 SpoVA protein; Region: SpoVA; cl04298 692420005292 stage V sporulation protein AD; Provisional; Region: PRK12404 692420005293 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420005294 SpoVA protein; Region: SpoVA; cl04298 692420005295 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420005296 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005297 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420005298 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420005299 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420005300 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420005301 putative active site [active] 692420005302 catalytic site [active] 692420005303 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420005304 putative active site [active] 692420005305 catalytic site [active] 692420005306 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420005307 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 692420005308 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 692420005309 NAD binding site [chemical binding]; other site 692420005310 substrate binding site [chemical binding]; other site 692420005311 catalytic Zn binding site [ion binding]; other site 692420005312 tetramer interface [polypeptide binding]; other site 692420005313 structural Zn binding site [ion binding]; other site 692420005314 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 692420005315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420005316 YoaP-like; Region: YoaP; pfam14268 692420005317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420005318 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420005319 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 692420005320 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 692420005321 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420005322 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 692420005323 Chitin binding domain; Region: Chitin_bind_3; cl03871 692420005324 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420005325 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420005326 TM2 domain; Region: TM2; cl00984 692420005327 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 692420005328 trimer interface [polypeptide binding]; other site 692420005329 active site 692420005330 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 692420005331 Protein of unknown function (DUF867); Region: DUF867; cl01713 692420005332 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 692420005333 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 692420005334 LexA repressor; Validated; Region: PRK00215 692420005335 Helix-turn-helix domains; Region: HTH; cl00088 692420005336 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 692420005337 Catalytic site [active] 692420005338 cell division suppressor protein YneA; Provisional; Region: PRK14125 692420005339 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 692420005340 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005341 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 692420005342 catalytic residues [active] 692420005343 catalytic nucleophile [active] 692420005344 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 692420005345 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 692420005346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 692420005347 TPP-binding site [chemical binding]; other site 692420005348 dimer interface [polypeptide binding]; other site 692420005349 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 692420005350 PYR/PP interface [polypeptide binding]; other site 692420005351 dimer interface [polypeptide binding]; other site 692420005352 TPP binding site [chemical binding]; other site 692420005353 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420005354 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 692420005355 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 692420005356 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420005357 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 692420005358 Response regulator receiver domain; Region: Response_reg; pfam00072 692420005359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420005360 active site 692420005361 phosphorylation site [posttranslational modification] 692420005362 intermolecular recognition site; other site 692420005363 dimerization interface [polypeptide binding]; other site 692420005364 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 692420005365 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 692420005366 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 692420005367 Small acid-soluble spore protein P family; Region: SspP; cl12105 692420005368 Small acid-soluble spore protein O family; Region: SspO; cl07943 692420005369 aconitate hydratase; Validated; Region: PRK09277 692420005370 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 692420005371 substrate binding site [chemical binding]; other site 692420005372 ligand binding site [chemical binding]; other site 692420005373 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 692420005374 substrate binding site [chemical binding]; other site 692420005375 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420005376 catalytic residues [active] 692420005377 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420005378 Small acid-soluble spore protein N family; Region: SspN; cl11659 692420005379 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 692420005380 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 692420005381 active site 692420005382 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 692420005383 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 692420005384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005385 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 692420005386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005387 ATP binding site [chemical binding]; other site 692420005388 Mg2+ binding site [ion binding]; other site 692420005389 G-X-G motif; other site 692420005390 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 692420005391 anchoring element; other site 692420005392 dimer interface [polypeptide binding]; other site 692420005393 ATP binding site [chemical binding]; other site 692420005394 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 692420005395 active site 692420005396 putative metal-binding site [ion binding]; other site 692420005397 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 692420005398 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 692420005399 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 692420005400 CAP-like domain; other site 692420005401 active site 692420005402 primary dimer interface [polypeptide binding]; other site 692420005403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005407 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 692420005408 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 692420005409 potential frameshift: common BLAST hit: gi|154686235|ref|YP_001421396.1| YndG 692420005410 potential frameshift: common BLAST hit: gi|154686235|ref|YP_001421396.1| YndG 692420005411 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 692420005412 YndJ-like protein; Region: YndJ; pfam14158 692420005413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 692420005414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420005415 dimer interface [polypeptide binding]; other site 692420005416 phosphorylation site [posttranslational modification] 692420005417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005418 ATP binding site [chemical binding]; other site 692420005419 Mg2+ binding site [ion binding]; other site 692420005420 G-X-G motif; other site 692420005421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420005422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420005423 active site 692420005424 phosphorylation site [posttranslational modification] 692420005425 intermolecular recognition site; other site 692420005426 dimerization interface [polypeptide binding]; other site 692420005427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420005428 DNA binding site [nucleotide binding] 692420005429 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 692420005430 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 692420005431 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 692420005432 substrate binding site [chemical binding]; other site 692420005433 active site 692420005434 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 692420005435 metal binding site [ion binding]; metal-binding site 692420005436 ligand binding site [chemical binding]; other site 692420005437 peptide synthase; Provisional; Region: PRK12467 692420005438 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005439 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005440 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005441 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005443 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 692420005444 peptide synthase; Provisional; Region: PRK12467 692420005445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005446 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005447 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005448 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005449 peptide synthase; Provisional; Region: PRK12316 692420005450 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005451 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005452 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005453 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005454 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005455 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005457 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005458 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005459 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005460 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005461 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420005462 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005463 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005465 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005466 active site 692420005467 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005468 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005469 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 692420005470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420005471 inhibitor-cofactor binding pocket; inhibition site 692420005472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005473 catalytic residue [active] 692420005474 Condensation domain; Region: Condensation; pfam00668 692420005475 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005476 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005477 peptide synthase; Provisional; Region: PRK12467 692420005478 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005479 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005480 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005481 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005482 Acyl transferase domain; Region: Acyl_transf_1; cl08282 692420005483 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005484 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 692420005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005486 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 692420005487 NAD(P) binding site [chemical binding]; other site 692420005488 active site 692420005489 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420005490 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420005491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420005492 biotin synthase; Validated; Region: PRK06256 692420005493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420005494 FeS/SAM binding site; other site 692420005495 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 692420005496 AAA domain; Region: AAA_26; pfam13500 692420005497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005499 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 692420005500 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 692420005501 substrate-cofactor binding pocket; other site 692420005502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005503 catalytic residue [active] 692420005504 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 692420005505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420005506 inhibitor-cofactor binding pocket; inhibition site 692420005507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005508 catalytic residue [active] 692420005509 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 692420005510 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 692420005511 GtrA-like protein; Region: GtrA; cl00971 692420005512 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 692420005513 active site 692420005514 tetramer interface; other site 692420005515 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420005516 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420005517 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 692420005518 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420005519 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420005520 enoyl-CoA hydratase; Provisional; Region: PRK07657 692420005521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005522 substrate binding site [chemical binding]; other site 692420005523 oxyanion hole (OAH) forming residues; other site 692420005524 trimer interface [polypeptide binding]; other site 692420005525 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 692420005526 active site 692420005527 catalytic residues [active] 692420005528 metal binding site [ion binding]; metal-binding site 692420005529 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420005530 carboxyltransferase (CT) interaction site; other site 692420005531 biotinylation site [posttranslational modification]; other site 692420005532 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 692420005533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420005534 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420005535 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 692420005536 potential frameshift: common BLAST hit: gi|154686271|ref|YP_001421432.1| AMP-binding domain protein 692420005537 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005538 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420005539 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005540 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420005541 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 692420005542 FAD binding site [chemical binding]; other site 692420005543 homotetramer interface [polypeptide binding]; other site 692420005544 substrate binding pocket [chemical binding]; other site 692420005545 catalytic base [active] 692420005546 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 692420005547 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 692420005548 peptide synthase; Provisional; Region: PRK12467 692420005549 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005550 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005551 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005552 peptide synthase; Provisional; Region: PRK12467 692420005553 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005554 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005555 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005557 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005558 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005559 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005560 AMP-binding enzyme; Region: AMP-binding; cl15778 692420005561 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420005562 Condensation domain; Region: Condensation; pfam00668 692420005563 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005564 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420005565 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 692420005566 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 692420005567 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 692420005568 active site 692420005569 catalytic residues [active] 692420005570 MatE; Region: MatE; cl10513 692420005571 MatE; Region: MatE; cl10513 692420005572 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 692420005573 Int/Topo IB signature motif; other site 692420005574 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420005575 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 692420005576 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 692420005577 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005579 putative substrate translocation pore; other site 692420005580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420005581 dimerization interface [polypeptide binding]; other site 692420005582 putative DNA binding site [nucleotide binding]; other site 692420005583 putative Zn2+ binding site [ion binding]; other site 692420005584 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 692420005585 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 692420005586 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 692420005587 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 692420005588 active site 692420005589 dimer interface [polypeptide binding]; other site 692420005590 motif 1; other site 692420005591 motif 2; other site 692420005592 motif 3; other site 692420005593 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 692420005594 anticodon binding site; other site 692420005595 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 692420005596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005597 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 692420005598 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 692420005599 active site 692420005600 dimer interface [polypeptide binding]; other site 692420005601 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 692420005602 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 692420005603 active site 692420005604 FMN binding site [chemical binding]; other site 692420005605 substrate binding site [chemical binding]; other site 692420005606 3Fe-4S cluster binding site [ion binding]; other site 692420005607 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 692420005608 domain interface; other site 692420005609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420005610 Helix-turn-helix domains; Region: HTH; cl00088 692420005611 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 692420005612 putative dimerization interface [polypeptide binding]; other site 692420005613 gamma-glutamyl kinase; Provisional; Region: PRK13402 692420005614 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 692420005615 nucleotide binding site [chemical binding]; other site 692420005616 homotetrameric interface [polypeptide binding]; other site 692420005617 putative phosphate binding site [ion binding]; other site 692420005618 putative allosteric binding site; other site 692420005619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005620 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 692420005621 Replication terminator protein; Region: RTP; pfam02334 692420005622 classical (c) SDRs; Region: SDR_c; cd05233 692420005623 NAD(P) binding site [chemical binding]; other site 692420005624 active site 692420005625 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 692420005626 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420005627 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420005628 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420005629 putative active site [active] 692420005630 catalytic site [active] 692420005631 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420005632 putative active site [active] 692420005633 catalytic site [active] 692420005634 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420005635 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420005636 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005637 SpoVA protein; Region: SpoVA; cl04298 692420005638 stage V sporulation protein AD; Provisional; Region: PRK12404 692420005639 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420005640 SpoVA protein; Region: SpoVA; cl04298 692420005641 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420005642 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005643 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005644 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420005645 catalytic residues [active] 692420005646 catalytic nucleophile [active] 692420005647 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420005648 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420005649 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420005650 Synaptic Site I dimer interface [polypeptide binding]; other site 692420005651 DNA binding site [nucleotide binding] 692420005652 Helix-turn-helix domains; Region: HTH; cl00088 692420005653 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420005654 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420005655 polyol permease family; Region: 2A0118; TIGR00897 692420005656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005657 putative substrate translocation pore; other site 692420005658 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 692420005659 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 692420005660 putative N- and C-terminal domain interface [polypeptide binding]; other site 692420005661 putative active site [active] 692420005662 putative MgATP binding site [chemical binding]; other site 692420005663 catalytic site [active] 692420005664 metal binding site [ion binding]; metal-binding site 692420005665 carbohydrate binding site [chemical binding]; other site 692420005666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005667 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 692420005668 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 692420005669 putative [4Fe-4S] binding site [ion binding]; other site 692420005670 putative molybdopterin cofactor binding site [chemical binding]; other site 692420005671 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 692420005672 putative molybdopterin cofactor binding site; other site 692420005673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420005674 Helix-turn-helix domains; Region: HTH; cl00088 692420005675 Helix-turn-helix domains; Region: HTH; cl00088 692420005676 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 692420005677 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 692420005678 dimer interface [polypeptide binding]; other site 692420005679 putative tRNA-binding site [nucleotide binding]; other site 692420005680 Cupin domain; Region: Cupin_2; cl09118 692420005681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420005682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420005683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420005684 Helix-turn-helix domains; Region: HTH; cl00088 692420005685 WHG domain; Region: WHG; pfam13305 692420005686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420005687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420005688 dimerization interface [polypeptide binding]; other site 692420005689 putative DNA binding site [nucleotide binding]; other site 692420005690 putative Zn2+ binding site [ion binding]; other site 692420005691 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 692420005692 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420005693 catalytic residue [active] 692420005694 Protein of unknown function (DUF420); Region: DUF420; cl00989 692420005695 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420005696 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 692420005697 putative dimer interface [polypeptide binding]; other site 692420005698 catalytic triad [active] 692420005699 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005700 putative peptidoglycan binding site; other site 692420005701 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005702 putative peptidoglycan binding site; other site 692420005703 3D domain; Region: 3D; cl01439 692420005704 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 692420005705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420005706 ATP binding site [chemical binding]; other site 692420005707 putative Mg++ binding site [ion binding]; other site 692420005708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420005709 nucleotide binding region [chemical binding]; other site 692420005710 ATP-binding site [chemical binding]; other site 692420005711 RQC domain; Region: RQC; cl09632 692420005712 HRDC domain; Region: HRDC; cl02578 692420005713 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420005714 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 692420005715 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 692420005716 putative dimer interface [polypeptide binding]; other site 692420005717 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 692420005718 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 692420005719 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420005720 NAD(P) binding site [chemical binding]; other site 692420005721 catalytic residues [active] 692420005722 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 692420005723 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 692420005724 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 692420005725 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 692420005726 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 692420005727 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 692420005728 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 692420005729 bile acid transporter; Region: bass; TIGR00841 692420005730 Membrane transport protein; Region: Mem_trans; cl09117 692420005731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420005732 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 692420005733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420005734 E3 interaction surface; other site 692420005735 lipoyl attachment site [posttranslational modification]; other site 692420005736 e3 binding domain; Region: E3_binding; pfam02817 692420005737 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 692420005738 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 692420005739 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 692420005740 TPP-binding site [chemical binding]; other site 692420005741 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 692420005742 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 692420005743 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 692420005744 metal ion-dependent adhesion site (MIDAS); other site 692420005745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420005746 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 692420005747 Walker A motif; other site 692420005748 ATP binding site [chemical binding]; other site 692420005749 Walker B motif; other site 692420005750 arginine finger; other site 692420005751 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 692420005752 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 692420005753 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 692420005754 E-class dimer interface [polypeptide binding]; other site 692420005755 P-class dimer interface [polypeptide binding]; other site 692420005756 active site 692420005757 Cu2+ binding site [ion binding]; other site 692420005758 Zn2+ binding site [ion binding]; other site 692420005759 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005760 putative peptidoglycan binding site; other site 692420005761 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420005762 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005763 putative peptidoglycan binding site; other site 692420005764 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420005765 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005766 putative peptidoglycan binding site; other site 692420005767 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420005768 putative peptidoglycan binding site; other site 692420005769 NlpC/P60 family; Region: NLPC_P60; cl11438 692420005770 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420005771 glycosyltransferase, MGT family; Region: MGT; TIGR01426 692420005772 active site 692420005773 TDP-binding site; other site 692420005774 acceptor substrate-binding pocket; other site 692420005775 homodimer interface [polypeptide binding]; other site 692420005776 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 692420005777 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420005778 multidrug efflux protein; Reviewed; Region: PRK01766 692420005779 MatE; Region: MatE; cl10513 692420005780 MatE; Region: MatE; cl10513 692420005781 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420005782 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 692420005783 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 692420005784 rarD protein; Region: rarD; TIGR00688 692420005785 EamA-like transporter family; Region: EamA; cl01037 692420005786 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 692420005787 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 692420005788 Helix-turn-helix domains; Region: HTH; cl00088 692420005789 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420005790 dimer interface [polypeptide binding]; other site 692420005791 FMN binding site [chemical binding]; other site 692420005792 Predicted esterase [General function prediction only]; Region: COG0400 692420005793 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420005794 Zn binding site [ion binding]; other site 692420005795 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420005796 Zn binding site [ion binding]; other site 692420005797 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 692420005798 Sodium:solute symporter family; Region: SSF; cl00456 692420005799 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 692420005800 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 692420005801 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420005802 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420005803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420005804 DNA-binding site [nucleotide binding]; DNA binding site 692420005805 UTRA domain; Region: UTRA; cl01230 692420005806 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 692420005807 C-terminal peptidase (prc); Region: prc; TIGR00225 692420005808 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 692420005809 protein binding site [polypeptide binding]; other site 692420005810 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 692420005811 Catalytic dyad [active] 692420005812 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420005813 Methyltransferase domain; Region: Methyltransf_31; pfam13847 692420005814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005815 S-adenosylmethionine binding site [chemical binding]; other site 692420005816 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 692420005817 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 692420005818 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 692420005819 YodL-like; Region: YodL; pfam14191 692420005820 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 692420005821 active site 692420005822 YozD-like protein; Region: YozD; pfam14162 692420005823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420005824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 692420005825 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 692420005826 YokU-like protein; Region: YokU; cl15819 692420005827 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 692420005828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420005829 FeS/SAM binding site; other site 692420005830 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 692420005831 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 692420005832 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420005833 acetylornithine deacetylase; Validated; Region: PRK06915 692420005834 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 692420005835 metal binding site [ion binding]; metal-binding site 692420005836 dimer interface [polypeptide binding]; other site 692420005837 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420005838 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420005839 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420005840 hypothetical protein; Provisional; Region: PRK06917 692420005841 inhibitor-cofactor binding pocket; inhibition site 692420005842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005843 catalytic residue [active] 692420005844 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420005845 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 692420005846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420005847 Coenzyme A binding pocket [chemical binding]; other site 692420005848 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420005849 active site 692420005850 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 692420005851 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420005852 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 692420005853 Phytase; Region: Phytase; pfam02333 692420005854 similar to capsular polysaccharide biosynthesis enzyme fragment; N-terminal part of YpqP 692420005855 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 692420005856 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 692420005857 putative active site [active] 692420005858 putative substrate binding site [chemical binding]; other site 692420005859 putative FMN binding site [chemical binding]; other site 692420005860 putative catalytic residues [active] 692420005861 Regulatory protein YrvL; Region: YrvL; pfam14184 692420005862 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 692420005863 catalytic residues [active] 692420005864 catalytic nucleophile [active] 692420005865 Recombinase; Region: Recombinase; pfam07508 692420005866 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 692420005867 similar to capsular polysaccharide biosynthesis enzyme fragment; C-terminal part of YpqP 692420005868 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 692420005869 SelR domain; Region: SelR; pfam01641 692420005870 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 692420005871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420005872 Helix-turn-helix domains; Region: HTH; cl00088 692420005873 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 692420005874 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 692420005875 active site 692420005876 catalytic triad [active] 692420005877 oxyanion hole [active] 692420005878 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 692420005879 Cu(I) binding site [ion binding]; other site 692420005880 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 692420005881 threonine dehydratase; Validated; Region: PRK08639 692420005882 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 692420005883 tetramer interface [polypeptide binding]; other site 692420005884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005885 catalytic residue [active] 692420005886 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 692420005887 putative Ile/Val binding site [chemical binding]; other site 692420005888 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 692420005889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420005890 Walker A motif; other site 692420005891 ATP binding site [chemical binding]; other site 692420005892 Walker B motif; other site 692420005893 arginine finger; other site 692420005894 Haemolysin-III related; Region: HlyIII; cl03831 692420005895 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 692420005896 putative acyl-acceptor binding pocket; other site 692420005897 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 692420005898 folate binding site [chemical binding]; other site 692420005899 NADP+ binding site [chemical binding]; other site 692420005900 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 692420005901 dimerization interface [polypeptide binding]; other site 692420005902 active site 692420005903 YpjP-like protein; Region: YpjP; pfam14005 692420005904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005905 Disulphide isomerase; Region: Disulph_isomer; pfam06491 692420005906 Dehydratase family; Region: ILVD_EDD; cl00340 692420005907 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 692420005908 Virulence factor; Region: Virulence_fact; pfam13769 692420005909 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 692420005910 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 692420005911 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 692420005912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 692420005913 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 692420005914 catalytic residues [active] 692420005915 dimer interface [polypeptide binding]; other site 692420005916 homoserine O-succinyltransferase; Provisional; Region: PRK05368 692420005917 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 692420005918 proposed active site lysine [active] 692420005919 conserved cys residue [active] 692420005920 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 692420005921 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420005922 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 692420005923 DNA-binding site [nucleotide binding]; DNA binding site 692420005924 RNA-binding motif; other site 692420005925 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 692420005926 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 692420005927 hypothetical protein; Validated; Region: PRK07708 692420005928 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 692420005929 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420005930 active site 692420005931 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 692420005932 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 692420005933 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420005934 active site 692420005935 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 692420005936 5'-3' exonuclease; Region: 53EXOc; smart00475 692420005937 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 692420005938 active site 692420005939 metal binding site 1 [ion binding]; metal-binding site 692420005940 putative 5' ssDNA interaction site; other site 692420005941 metal binding site 3; metal-binding site 692420005942 metal binding site 2 [ion binding]; metal-binding site 692420005943 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 692420005944 putative DNA binding site [nucleotide binding]; other site 692420005945 putative metal binding site [ion binding]; other site 692420005946 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 692420005947 GTP-binding protein Der; Reviewed; Region: PRK00093 692420005948 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 692420005949 Dynamin family; Region: Dynamin_N; pfam00350 692420005950 G1 box; other site 692420005951 GTP/Mg2+ binding site [chemical binding]; other site 692420005952 G2 box; other site 692420005953 Switch I region; other site 692420005954 G3 box; other site 692420005955 Switch II region; other site 692420005956 G4 box; other site 692420005957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005958 G1 box; other site 692420005959 GTP/Mg2+ binding site [chemical binding]; other site 692420005960 Dynamin family; Region: Dynamin_N; pfam00350 692420005961 G2 box; other site 692420005962 Switch I region; other site 692420005963 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 692420005964 G3 box; other site 692420005965 Switch II region; other site 692420005966 GTP/Mg2+ binding site [chemical binding]; other site 692420005967 G4 box; other site 692420005968 G5 box; other site 692420005969 Phospholipid methyltransferase; Region: PEMT; cl00763 692420005970 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 692420005971 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 692420005972 malonyl-CoA binding site [chemical binding]; other site 692420005973 dimer interface [polypeptide binding]; other site 692420005974 active site 692420005975 product binding site; other site 692420005976 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 692420005977 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420005978 DNA binding site [nucleotide binding] 692420005979 active site 692420005980 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 692420005981 xanthine permease; Region: pbuX; TIGR03173 692420005982 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 692420005983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420005984 active site 692420005985 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 692420005986 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 692420005987 active site 692420005988 Zn binding site [ion binding]; other site 692420005989 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 692420005990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005991 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420005992 YpzG-like protein; Region: YpzG; pfam14139 692420005993 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 692420005994 THUMP domain; Region: THUMP; cl12076 692420005995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005996 cell division protein GpsB; Provisional; Region: PRK14127 692420005997 DivIVA domain; Region: DivI1A_domain; TIGR03544 692420005998 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 692420005999 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 692420006000 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 692420006001 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 692420006002 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 692420006003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006004 ATP binding site [chemical binding]; other site 692420006005 putative Mg++ binding site [ion binding]; other site 692420006006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006007 nucleotide binding region [chemical binding]; other site 692420006008 ATP-binding site [chemical binding]; other site 692420006009 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 692420006010 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 692420006011 HPr interaction site; other site 692420006012 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420006013 active site 692420006014 phosphorylation site [posttranslational modification] 692420006015 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 692420006016 YppG-like protein; Region: YppG; pfam14179 692420006017 YppF-like protein; Region: YppF; pfam14178 692420006018 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 692420006019 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 692420006020 Recombination protein U; Region: RecU; cl01314 692420006021 Transglycosylase; Region: Transgly; cl07896 692420006022 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420006023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420006024 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 692420006025 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 692420006026 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420006027 minor groove reading motif; other site 692420006028 helix-hairpin-helix signature motif; other site 692420006029 substrate binding pocket [chemical binding]; other site 692420006030 active site 692420006031 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 692420006032 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 692420006033 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 692420006034 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 692420006035 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 692420006036 putative dimer interface [polypeptide binding]; other site 692420006037 putative anticodon binding site; other site 692420006038 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 692420006039 homodimer interface [polypeptide binding]; other site 692420006040 motif 1; other site 692420006041 motif 2; other site 692420006042 active site 692420006043 motif 3; other site 692420006044 aspartate aminotransferase; Provisional; Region: PRK05764 692420006045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420006046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006047 homodimer interface [polypeptide binding]; other site 692420006048 catalytic residue [active] 692420006049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 692420006050 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420006051 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 692420006052 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 692420006053 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 692420006054 active site 692420006055 substrate binding site [chemical binding]; other site 692420006056 catalytic site [active] 692420006057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420006058 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 692420006059 tetramerization interface [polypeptide binding]; other site 692420006060 active site 692420006061 Pantoate-beta-alanine ligase; Region: PanC; cd00560 692420006062 pantoate--beta-alanine ligase; Region: panC; TIGR00018 692420006063 active site 692420006064 ATP-binding site [chemical binding]; other site 692420006065 pantoate-binding site; other site 692420006066 HXXH motif; other site 692420006067 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 692420006068 oligomerization interface [polypeptide binding]; other site 692420006069 active site 692420006070 metal binding site [ion binding]; metal-binding site 692420006071 Helix-turn-helix domains; Region: HTH; cl00088 692420006072 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 692420006073 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 692420006074 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 692420006075 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 692420006076 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 692420006077 active site 692420006078 NTP binding site [chemical binding]; other site 692420006079 metal binding triad [ion binding]; metal-binding site 692420006080 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 692420006081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 692420006082 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 692420006083 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 692420006084 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 692420006085 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 692420006086 active site 692420006087 dimer interfaces [polypeptide binding]; other site 692420006088 catalytic residues [active] 692420006089 dihydrodipicolinate reductase; Region: dapB; TIGR00036 692420006090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006091 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 692420006092 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 692420006093 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420006094 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006095 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006096 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420006097 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 692420006098 Cupin domain; Region: Cupin_2; cl09118 692420006099 Cupin domain; Region: Cupin_2; cl09118 692420006100 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 692420006101 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 692420006102 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 692420006103 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 692420006104 Cytochrome c; Region: Cytochrom_C; cl11414 692420006105 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 692420006106 interchain domain interface [polypeptide binding]; other site 692420006107 intrachain domain interface; other site 692420006108 heme bH binding site [chemical binding]; other site 692420006109 Qi binding site; other site 692420006110 heme bL binding site [chemical binding]; other site 692420006111 Qo binding site; other site 692420006112 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 692420006113 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 692420006114 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 692420006115 iron-sulfur cluster [ion binding]; other site 692420006116 [2Fe-2S] cluster binding site [ion binding]; other site 692420006117 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 692420006118 hypothetical protein; Provisional; Region: PRK03636 692420006119 UPF0302 domain; Region: UPF0302; pfam08864 692420006120 IDEAL domain; Region: IDEAL; cl07452 692420006121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420006122 TPR motif; other site 692420006123 binding surface 692420006124 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 692420006125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420006126 binding surface 692420006127 TPR motif; other site 692420006128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420006129 binding surface 692420006130 TPR motif; other site 692420006131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420006132 binding surface 692420006133 TPR motif; other site 692420006134 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 692420006135 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 692420006136 hinge; other site 692420006137 active site 692420006138 prephenate dehydrogenase; Validated; Region: PRK06545 692420006139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006140 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 692420006141 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 692420006142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006144 homodimer interface [polypeptide binding]; other site 692420006145 catalytic residue [active] 692420006146 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 692420006147 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 692420006148 substrate binding site [chemical binding]; other site 692420006149 active site 692420006150 catalytic residues [active] 692420006151 heterodimer interface [polypeptide binding]; other site 692420006152 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 692420006153 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 692420006154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006155 catalytic residue [active] 692420006156 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 692420006157 active site 692420006158 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 692420006159 active site 692420006160 ribulose/triose binding site [chemical binding]; other site 692420006161 phosphate binding site [ion binding]; other site 692420006162 substrate (anthranilate) binding pocket [chemical binding]; other site 692420006163 product (indole) binding pocket [chemical binding]; other site 692420006164 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 692420006165 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 692420006166 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 692420006167 anthranilate synthase component I; Provisional; Region: PRK13569 692420006168 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 692420006169 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420006170 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 692420006171 homotrimer interaction site [polypeptide binding]; other site 692420006172 active site 692420006173 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 692420006174 active site 692420006175 dimer interface [polypeptide binding]; other site 692420006176 metal binding site [ion binding]; metal-binding site 692420006177 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 692420006178 Tetramer interface [polypeptide binding]; other site 692420006179 active site 692420006180 FMN-binding site [chemical binding]; other site 692420006181 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 692420006182 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 692420006183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006184 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 692420006185 active site 692420006186 multimer interface [polypeptide binding]; other site 692420006187 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 692420006188 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 692420006189 substrate binding pocket [chemical binding]; other site 692420006190 chain length determination region; other site 692420006191 substrate-Mg2+ binding site; other site 692420006192 catalytic residues [active] 692420006193 aspartate-rich region 1; other site 692420006194 active site lid residues [active] 692420006195 aspartate-rich region 2; other site 692420006196 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 692420006197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420006198 S-adenosylmethionine binding site [chemical binding]; other site 692420006199 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 692420006200 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 692420006201 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 692420006202 homodecamer interface [polypeptide binding]; other site 692420006203 GTP cyclohydrolase I; Provisional; Region: PLN03044 692420006204 active site 692420006205 putative catalytic site residues [active] 692420006206 zinc binding site [ion binding]; other site 692420006207 GTP-CH-I/GFRP interaction surface; other site 692420006208 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 692420006209 IHF dimer interface [polypeptide binding]; other site 692420006210 IHF - DNA interface [nucleotide binding]; other site 692420006211 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 692420006212 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 692420006213 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 692420006214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006215 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 692420006216 GTP-binding protein Der; Reviewed; Region: PRK00093 692420006217 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 692420006218 G1 box; other site 692420006219 GTP/Mg2+ binding site [chemical binding]; other site 692420006220 Switch I region; other site 692420006221 G2 box; other site 692420006222 Switch II region; other site 692420006223 G3 box; other site 692420006224 G4 box; other site 692420006225 G5 box; other site 692420006226 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 692420006227 G1 box; other site 692420006228 GTP/Mg2+ binding site [chemical binding]; other site 692420006229 Switch I region; other site 692420006230 G2 box; other site 692420006231 G3 box; other site 692420006232 Switch II region; other site 692420006233 G4 box; other site 692420006234 G5 box; other site 692420006235 YpzI-like protein; Region: YpzI; pfam14140 692420006236 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 692420006237 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 692420006238 homotetramer interface [polypeptide binding]; other site 692420006239 FMN binding site [chemical binding]; other site 692420006240 homodimer contacts [polypeptide binding]; other site 692420006241 putative active site [active] 692420006242 putative substrate binding site [chemical binding]; other site 692420006243 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 692420006244 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 692420006245 RNA binding site [nucleotide binding]; other site 692420006246 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 692420006247 RNA binding site [nucleotide binding]; other site 692420006248 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 692420006249 RNA binding site [nucleotide binding]; other site 692420006250 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 692420006251 RNA binding site [nucleotide binding]; other site 692420006252 cytidylate kinase; Provisional; Region: cmk; PRK00023 692420006253 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 692420006254 CMP-binding site; other site 692420006255 The sites determining sugar specificity; other site 692420006256 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 692420006257 Flagellar protein YcgR; Region: YcgR_2; pfam12945 692420006258 PilZ domain; Region: PilZ; cl01260 692420006259 germination protein YpeB; Region: spore_YpeB; TIGR02889 692420006260 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 692420006261 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420006262 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420006263 Protease prsW family; Region: PrsW-protease; cl15823 692420006264 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 692420006265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420006267 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420006268 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420006269 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 692420006270 NAD(P) binding site [chemical binding]; other site 692420006271 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 692420006272 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 692420006273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420006274 putative active site [active] 692420006275 putative metal binding site [ion binding]; other site 692420006276 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 692420006277 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 692420006278 CAAX protease self-immunity; Region: Abi; cl00558 692420006279 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 692420006280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006281 ATP binding site [chemical binding]; other site 692420006282 putative Mg++ binding site [ion binding]; other site 692420006283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006284 nucleotide binding region [chemical binding]; other site 692420006285 ATP-binding site [chemical binding]; other site 692420006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 692420006287 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 692420006288 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420006289 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 692420006290 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 692420006291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006292 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 692420006293 putative L-serine binding site [chemical binding]; other site 692420006294 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 692420006295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420006296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420006297 DNA binding residues [nucleotide binding] 692420006298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 692420006299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420006300 dimerization interface [polypeptide binding]; other site 692420006301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420006302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420006303 dimer interface [polypeptide binding]; other site 692420006304 phosphorylation site [posttranslational modification] 692420006305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420006306 ATP binding site [chemical binding]; other site 692420006307 Mg2+ binding site [ion binding]; other site 692420006308 G-X-G motif; other site 692420006309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420006310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420006311 active site 692420006312 phosphorylation site [posttranslational modification] 692420006313 intermolecular recognition site; other site 692420006314 dimerization interface [polypeptide binding]; other site 692420006315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420006316 DNA binding site [nucleotide binding] 692420006317 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 692420006318 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 692420006319 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 692420006320 ResB-like family; Region: ResB; pfam05140 692420006321 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420006322 catalytic residues [active] 692420006323 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420006324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420006325 RNA binding surface [nucleotide binding]; other site 692420006326 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 692420006327 active site 692420006328 Nucleoside recognition; Region: Gate; cl00486 692420006329 Nucleoside recognition; Region: Gate; cl00486 692420006330 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420006331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420006332 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 692420006333 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 692420006334 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 692420006335 ScpA/B protein; Region: ScpA_ScpB; cl00598 692420006336 Domain of unknown function (DUF309); Region: DUF309; cl00667 692420006337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006338 Coenzyme A binding pocket [chemical binding]; other site 692420006339 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 692420006340 homopentamer interface [polypeptide binding]; other site 692420006341 active site 692420006342 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 692420006343 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 692420006344 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 692420006345 dimerization interface [polypeptide binding]; other site 692420006346 active site 692420006347 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 692420006348 Lumazine binding domain; Region: Lum_binding; pfam00677 692420006349 Lumazine binding domain; Region: Lum_binding; pfam00677 692420006350 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 692420006351 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 692420006352 catalytic motif [active] 692420006353 Zn binding site [ion binding]; other site 692420006354 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 692420006355 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 692420006356 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420006357 Catalytic site [active] 692420006358 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 692420006359 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 692420006360 active site 692420006361 Predicted secreted protein [Function unknown]; Region: COG4086 692420006362 diaminopimelate decarboxylase; Region: lysA; TIGR01048 692420006363 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 692420006364 active site 692420006365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420006366 substrate binding site [chemical binding]; other site 692420006367 catalytic residues [active] 692420006368 dimer interface [polypeptide binding]; other site 692420006369 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420006370 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 692420006371 SpoVA protein; Region: SpoVA; cl04298 692420006372 stage V sporulation protein AD; Validated; Region: PRK08304 692420006373 stage V sporulation protein AD; Provisional; Region: PRK12404 692420006374 SpoVA protein; Region: SpoVA; cl04298 692420006375 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 692420006376 sporulation sigma factor SigF; Validated; Region: PRK05572 692420006377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420006378 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420006379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420006380 DNA binding residues [nucleotide binding] 692420006381 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420006382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420006383 ATP binding site [chemical binding]; other site 692420006384 Mg2+ binding site [ion binding]; other site 692420006385 G-X-G motif; other site 692420006386 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 692420006387 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420006388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420006389 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 692420006390 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 692420006391 Sulfatase; Region: Sulfatase; cl10460 692420006392 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 692420006393 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 692420006394 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 692420006395 Int/Topo IB signature motif; other site 692420006396 active site 692420006397 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 692420006398 ferric uptake regulator; Provisional; Region: fur; PRK09462 692420006399 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420006400 metal binding site 2 [ion binding]; metal-binding site 692420006401 putative DNA binding helix; other site 692420006402 metal binding site 1 [ion binding]; metal-binding site 692420006403 dimer interface [polypeptide binding]; other site 692420006404 structural Zn2+ binding site [ion binding]; other site 692420006405 Integral membrane protein DUF95; Region: DUF95; cl00572 692420006406 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 692420006407 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420006408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006409 NAD(P) binding pocket [chemical binding]; other site 692420006410 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 692420006411 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 692420006412 Aspartase; Region: Aspartase; cd01357 692420006413 active sites [active] 692420006414 tetramer interface [polypeptide binding]; other site 692420006415 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 692420006416 active site 692420006417 homodimer interface [polypeptide binding]; other site 692420006418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420006419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420006420 non-specific DNA binding site [nucleotide binding]; other site 692420006421 salt bridge; other site 692420006422 sequence-specific DNA binding site [nucleotide binding]; other site 692420006423 TIGR00375 family protein; Region: TIGR00375 692420006424 PHP-associated; Region: PHP_C; pfam13263 692420006425 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 692420006426 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 692420006427 dimer interface [polypeptide binding]; other site 692420006428 ADP-ribose binding site [chemical binding]; other site 692420006429 active site 692420006430 nudix motif; other site 692420006431 metal binding site [ion binding]; metal-binding site 692420006432 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 692420006433 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 692420006434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420006435 active site 692420006436 catalytic tetrad [active] 692420006437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 692420006438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420006439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420006440 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 692420006441 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 692420006442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 692420006443 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420006444 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 692420006445 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 692420006446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006447 Coenzyme A binding pocket [chemical binding]; other site 692420006448 DNA polymerase IV; Reviewed; Region: PRK03103 692420006449 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 692420006450 active site 692420006451 DNA binding site [nucleotide binding] 692420006452 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420006453 YolD-like protein; Region: YolD; pfam08863 692420006454 YqzH-like protein; Region: YqzH; pfam14164 692420006455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420006456 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420006457 pantothenate kinase; Provisional; Region: PRK05439 692420006458 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 692420006459 ATP-binding site [chemical binding]; other site 692420006460 CoA-binding site [chemical binding]; other site 692420006461 Mg2+-binding site [ion binding]; other site 692420006462 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 692420006463 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 692420006464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420006465 catalytic residue [active] 692420006466 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 692420006467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006468 NAD(P) binding site [chemical binding]; other site 692420006469 active site 692420006470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420006471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006472 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 692420006473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420006474 Helix-turn-helix domains; Region: HTH; cl00088 692420006475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420006476 dimerization interface [polypeptide binding]; other site 692420006477 GlpM protein; Region: GlpM; cl01212 692420006478 potential frameshift: common BLAST hit: gi|154686643|ref|YP_001421804.1| NADPH dehydrogenase NamA 692420006479 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 692420006480 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 692420006481 phosphate binding site [ion binding]; other site 692420006482 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420006483 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 692420006484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420006485 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 692420006486 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 692420006487 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 692420006488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006489 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 692420006490 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 692420006491 DNA polymerase IV; Validated; Region: PRK01810 692420006492 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 692420006493 active site 692420006494 DNA binding site [nucleotide binding] 692420006495 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420006496 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 692420006497 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 692420006498 peptidase T-like protein; Region: PepT-like; TIGR01883 692420006499 metal binding site [ion binding]; metal-binding site 692420006500 putative dimer interface [polypeptide binding]; other site 692420006501 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 692420006502 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420006503 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420006504 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420006505 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 692420006506 dimer interface [polypeptide binding]; other site 692420006507 substrate binding site [chemical binding]; other site 692420006508 metal binding site [ion binding]; metal-binding site 692420006509 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 692420006510 Predicted membrane protein [Function unknown]; Region: COG4129 692420006511 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 692420006512 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 692420006513 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420006514 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 692420006515 Walker A/P-loop; other site 692420006516 ATP binding site [chemical binding]; other site 692420006517 Q-loop/lid; other site 692420006518 ABC transporter signature motif; other site 692420006519 Walker B; other site 692420006520 D-loop; other site 692420006521 H-loop/switch region; other site 692420006522 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420006524 dimer interface [polypeptide binding]; other site 692420006525 conserved gate region; other site 692420006526 putative PBP binding loops; other site 692420006527 ABC-ATPase subunit interface; other site 692420006528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420006529 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420006530 substrate binding pocket [chemical binding]; other site 692420006531 membrane-bound complex binding site; other site 692420006532 hinge residues; other site 692420006533 Disulphide isomerase; Region: Disulph_isomer; pfam06491 692420006534 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 692420006535 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 692420006536 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420006537 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420006538 E3 interaction surface; other site 692420006539 lipoyl attachment site [posttranslational modification]; other site 692420006540 e3 binding domain; Region: E3_binding; pfam02817 692420006541 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 692420006542 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420006543 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420006544 alpha subunit interface [polypeptide binding]; other site 692420006545 TPP binding site [chemical binding]; other site 692420006546 heterodimer interface [polypeptide binding]; other site 692420006547 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420006548 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 692420006549 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420006550 tetramer interface [polypeptide binding]; other site 692420006551 TPP-binding site [chemical binding]; other site 692420006552 heterodimer interface [polypeptide binding]; other site 692420006553 phosphorylation loop region [posttranslational modification] 692420006554 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 692420006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420006557 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420006558 Acetokinase family; Region: Acetate_kinase; cl01029 692420006559 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420006560 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420006561 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 692420006562 NAD binding site [chemical binding]; other site 692420006563 Phe binding site; other site 692420006564 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 692420006565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006566 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 692420006567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420006568 putative active site [active] 692420006569 heme pocket [chemical binding]; other site 692420006570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420006571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420006572 Walker A motif; other site 692420006573 ATP binding site [chemical binding]; other site 692420006574 Walker B motif; other site 692420006575 arginine finger; other site 692420006576 Helix-turn-helix domains; Region: HTH; cl00088 692420006577 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 692420006578 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 692420006579 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 692420006580 tetramer interface [polypeptide binding]; other site 692420006581 active site 692420006582 Mg2+/Mn2+ binding site [ion binding]; other site 692420006583 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 692420006584 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 692420006585 dimer interface [polypeptide binding]; other site 692420006586 Citrate synthase; Region: Citrate_synt; pfam00285 692420006587 active site 692420006588 coenzyme A binding site [chemical binding]; other site 692420006589 citrylCoA binding site [chemical binding]; other site 692420006590 oxalacetate/citrate binding site [chemical binding]; other site 692420006591 catalytic triad [active] 692420006592 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420006593 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 692420006594 FAD binding site [chemical binding]; other site 692420006595 homotetramer interface [polypeptide binding]; other site 692420006596 substrate binding pocket [chemical binding]; other site 692420006597 catalytic base [active] 692420006598 potential frameshift: common BLAST hit: gi|154686675|ref|YP_001421836.1| MmgB 692420006599 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420006600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006601 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 692420006602 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420006603 dimer interface [polypeptide binding]; other site 692420006604 active site 692420006605 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 692420006606 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 692420006607 active site 692420006608 catalytic site [active] 692420006609 metal binding site [ion binding]; metal-binding site 692420006610 dimer interface [polypeptide binding]; other site 692420006611 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420006612 active site 692420006613 metal binding site [ion binding]; metal-binding site 692420006614 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 692420006615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420006616 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 692420006617 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 692420006618 putative active site [active] 692420006619 putative FMN binding site [chemical binding]; other site 692420006620 putative substrate binding site [chemical binding]; other site 692420006621 putative catalytic residue [active] 692420006622 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420006623 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420006624 alanine racemase; Region: alr; TIGR00492 692420006625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 692420006626 active site 692420006627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420006628 dimer interface [polypeptide binding]; other site 692420006629 substrate binding site [chemical binding]; other site 692420006630 catalytic residues [active] 692420006631 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 692420006632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420006633 active site 692420006634 phosphorylation site [posttranslational modification] 692420006635 intermolecular recognition site; other site 692420006636 dimerization interface [polypeptide binding]; other site 692420006637 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 692420006638 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 692420006639 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 692420006640 protein binding site [polypeptide binding]; other site 692420006641 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 692420006642 DNA repair protein RecN; Region: recN; TIGR00634 692420006643 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 692420006644 Walker A/P-loop; other site 692420006645 ATP binding site [chemical binding]; other site 692420006646 Q-loop/lid; other site 692420006647 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 692420006648 ABC transporter signature motif; other site 692420006649 Walker B; other site 692420006650 D-loop; other site 692420006651 H-loop/switch region; other site 692420006652 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 692420006653 arginine repressor; Provisional; Region: PRK04280 692420006654 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 692420006655 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 692420006656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420006657 RNA binding surface [nucleotide binding]; other site 692420006658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420006659 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 692420006660 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 692420006661 TPP-binding site; other site 692420006662 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 692420006663 PYR/PP interface [polypeptide binding]; other site 692420006664 dimer interface [polypeptide binding]; other site 692420006665 TPP binding site [chemical binding]; other site 692420006666 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420006667 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 692420006668 substrate binding pocket [chemical binding]; other site 692420006669 chain length determination region; other site 692420006670 substrate-Mg2+ binding site; other site 692420006671 catalytic residues [active] 692420006672 aspartate-rich region 1; other site 692420006673 active site lid residues [active] 692420006674 aspartate-rich region 2; other site 692420006675 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 692420006676 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 692420006677 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 692420006678 generic binding surface II; other site 692420006679 generic binding surface I; other site 692420006680 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 692420006681 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 692420006682 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 692420006683 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 692420006684 homodimer interface [polypeptide binding]; other site 692420006685 NADP binding site [chemical binding]; other site 692420006686 substrate binding site [chemical binding]; other site 692420006687 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 692420006688 putative RNA binding site [nucleotide binding]; other site 692420006689 Asp23 family; Region: Asp23; cl00574 692420006690 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 692420006691 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420006692 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 692420006693 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 692420006694 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420006695 carboxyltransferase (CT) interaction site; other site 692420006696 biotinylation site [posttranslational modification]; other site 692420006697 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 692420006698 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 692420006699 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 692420006700 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 692420006701 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 692420006702 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 692420006703 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 692420006704 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 692420006705 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 692420006706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420006707 Walker A motif; other site 692420006708 ATP binding site [chemical binding]; other site 692420006709 Walker B motif; other site 692420006710 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 692420006711 elongation factor P; Validated; Region: PRK00529 692420006712 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 692420006713 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 692420006714 RNA binding site [nucleotide binding]; other site 692420006715 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 692420006716 RNA binding site [nucleotide binding]; other site 692420006717 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 692420006718 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 692420006719 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 692420006720 active site 692420006721 Conserved membrane protein YqhR; Region: YqhR; pfam11085 692420006722 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 692420006723 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 692420006724 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 692420006725 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 692420006726 active site 692420006727 nucleophile elbow; other site 692420006728 manganese transport transcriptional regulator; Provisional; Region: PRK03902 692420006729 Helix-turn-helix domains; Region: HTH; cl00088 692420006730 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 692420006731 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 692420006732 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 692420006733 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 692420006734 active site residue [active] 692420006735 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 692420006736 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 692420006737 tetramer interface [polypeptide binding]; other site 692420006738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006739 catalytic residue [active] 692420006740 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 692420006741 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 692420006742 tetramer interface [polypeptide binding]; other site 692420006743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006744 catalytic residue [active] 692420006745 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 692420006746 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 692420006747 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 692420006748 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420006749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006750 ATP binding site [chemical binding]; other site 692420006751 putative Mg++ binding site [ion binding]; other site 692420006752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006753 nucleotide binding region [chemical binding]; other site 692420006754 ATP-binding site [chemical binding]; other site 692420006755 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 692420006756 Anti-repressor SinI; Region: SinI; pfam08671 692420006757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420006758 non-specific DNA binding site [nucleotide binding]; other site 692420006759 salt bridge; other site 692420006760 sequence-specific DNA binding site [nucleotide binding]; other site 692420006761 Anti-repressor SinI; Region: SinI; pfam08671 692420006762 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 692420006763 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420006764 Catalytic site [active] 692420006765 YqxM protein; Region: YqxM_for_SipW; TIGR04087 692420006766 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 692420006767 YqzE-like protein; Region: YqzE; pfam14038 692420006768 ComG operon protein 7; Region: ComGG; pfam14173 692420006769 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 692420006770 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 692420006771 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 692420006772 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 692420006773 Type II/IV secretion system protein; Region: T2SE; pfam00437 692420006774 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 692420006775 Walker A motif; other site 692420006776 ATP binding site [chemical binding]; other site 692420006777 Walker B motif; other site 692420006778 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 692420006779 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 692420006780 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420006781 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420006782 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420006783 Transporter associated domain; Region: CorC_HlyC; cl08393 692420006784 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420006785 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 692420006786 ArsC family; Region: ArsC; pfam03960 692420006787 putative catalytic residues [active] 692420006788 thiol/disulfide switch; other site 692420006789 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 692420006790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420006791 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 692420006792 Domain of unknown function DUF77; Region: DUF77; cl00307 692420006793 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 692420006794 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 692420006795 putative active site [active] 692420006796 Zn binding site [ion binding]; other site 692420006797 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 692420006798 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 692420006799 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 692420006800 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 692420006801 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420006802 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 692420006803 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 692420006804 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 692420006805 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 692420006806 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 692420006807 Walker A/P-loop; other site 692420006808 ATP binding site [chemical binding]; other site 692420006809 Q-loop/lid; other site 692420006810 ABC transporter signature motif; other site 692420006811 Walker B; other site 692420006812 D-loop; other site 692420006813 H-loop/switch region; other site 692420006814 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 692420006815 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 692420006816 Walker A/P-loop; other site 692420006817 ATP binding site [chemical binding]; other site 692420006818 Q-loop/lid; other site 692420006819 ABC transporter signature motif; other site 692420006820 Walker B; other site 692420006821 D-loop; other site 692420006822 H-loop/switch region; other site 692420006823 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 692420006824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420006825 dimer interface [polypeptide binding]; other site 692420006826 conserved gate region; other site 692420006827 ABC-ATPase subunit interface; other site 692420006828 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 692420006829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420006830 dimer interface [polypeptide binding]; other site 692420006831 conserved gate region; other site 692420006832 putative PBP binding loops; other site 692420006833 ABC-ATPase subunit interface; other site 692420006834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420006835 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 692420006836 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420006837 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420006838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420006840 putative substrate translocation pore; other site 692420006841 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 692420006842 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 692420006843 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 692420006844 Protein of unknown function (DUF456); Region: DUF456; cl01069 692420006845 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 692420006846 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 692420006847 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 692420006848 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 692420006849 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 692420006850 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420006851 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420006852 metal binding site 2 [ion binding]; metal-binding site 692420006853 putative DNA binding helix; other site 692420006854 metal binding site 1 [ion binding]; metal-binding site 692420006855 dimer interface [polypeptide binding]; other site 692420006856 structural Zn2+ binding site [ion binding]; other site 692420006857 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420006858 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006859 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006860 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420006861 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 692420006862 endonuclease IV; Provisional; Region: PRK01060 692420006863 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 692420006864 AP (apurinic/apyrimidinic) site pocket; other site 692420006865 DNA interaction; other site 692420006866 Metal-binding active site; metal-binding site 692420006867 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420006868 DEAD-like helicases superfamily; Region: DEXDc; smart00487 692420006869 ATP binding site [chemical binding]; other site 692420006870 Mg++ binding site [ion binding]; other site 692420006871 motif III; other site 692420006872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006873 nucleotide binding region [chemical binding]; other site 692420006874 ATP-binding site [chemical binding]; other site 692420006875 YqfQ-like protein; Region: YqfQ; pfam14181 692420006876 LytB protein; Region: LYTB; cl00507 692420006877 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 692420006878 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 692420006879 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 692420006880 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 692420006881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006882 Cytochrome c; Region: Cytochrom_C; cl11414 692420006883 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 692420006884 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 692420006885 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 692420006886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420006887 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420006888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420006889 DNA binding residues [nucleotide binding] 692420006890 DNA primase; Validated; Region: dnaG; PRK05667 692420006891 CHC2 zinc finger; Region: zf-CHC2; cl15369 692420006892 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 692420006893 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 692420006894 active site 692420006895 metal binding site [ion binding]; metal-binding site 692420006896 interdomain interaction site; other site 692420006897 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 692420006898 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 692420006899 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 692420006900 Helix-turn-helix domains; Region: HTH; cl00088 692420006901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 692420006902 FOG: CBS domain [General function prediction only]; Region: COG0517 692420006903 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 692420006904 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 692420006905 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 692420006906 dimer interface [polypeptide binding]; other site 692420006907 motif 1; other site 692420006908 active site 692420006909 motif 2; other site 692420006910 motif 3; other site 692420006911 Recombination protein O N terminal; Region: RecO_N; cl15812 692420006912 DNA repair protein RecO; Region: reco; TIGR00613 692420006913 Recombination protein O C terminal; Region: RecO_C; pfam02565 692420006914 GTPase Era; Reviewed; Region: era; PRK00089 692420006915 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 692420006916 G1 box; other site 692420006917 GTP/Mg2+ binding site [chemical binding]; other site 692420006918 Switch I region; other site 692420006919 G2 box; other site 692420006920 Switch II region; other site 692420006921 G3 box; other site 692420006922 G4 box; other site 692420006923 G5 box; other site 692420006924 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 692420006925 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 692420006926 active site 692420006927 catalytic motif [active] 692420006928 Zn binding site [ion binding]; other site 692420006929 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 692420006930 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 692420006931 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 692420006932 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 692420006933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420006934 Zn2+ binding site [ion binding]; other site 692420006935 Mg2+ binding site [ion binding]; other site 692420006936 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 692420006937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420006938 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 692420006939 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 692420006940 YabP family; Region: YabP; cl06766 692420006941 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 692420006942 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 692420006943 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 692420006944 dimer interface [polypeptide binding]; other site 692420006945 active site residues [active] 692420006946 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 692420006947 GatB domain; Region: GatB_Yqey; cl11497 692420006948 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 692420006949 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 692420006950 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 692420006951 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 692420006952 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 692420006953 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 692420006954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420006955 FeS/SAM binding site; other site 692420006956 TRAM domain; Region: TRAM; cl01282 692420006957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 692420006958 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 692420006959 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 692420006960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420006961 S-adenosylmethionine binding site [chemical binding]; other site 692420006962 chaperone protein DnaJ; Provisional; Region: PRK14280 692420006963 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 692420006964 HSP70 interaction site [polypeptide binding]; other site 692420006965 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 692420006966 substrate binding site [polypeptide binding]; other site 692420006967 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 692420006968 Zn binding sites [ion binding]; other site 692420006969 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 692420006970 dimer interface [polypeptide binding]; other site 692420006971 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 692420006972 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 692420006973 dimer interface [polypeptide binding]; other site 692420006974 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 692420006975 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 692420006976 Helix-turn-helix domains; Region: HTH; cl00088 692420006977 HrcA protein C terminal domain; Region: HrcA; pfam01628 692420006978 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 692420006979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420006980 FeS/SAM binding site; other site 692420006981 HemN C-terminal domain; Region: HemN_C; pfam06969 692420006982 GTP-binding protein LepA; Provisional; Region: PRK05433 692420006983 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 692420006984 G1 box; other site 692420006985 putative GEF interaction site [polypeptide binding]; other site 692420006986 GTP/Mg2+ binding site [chemical binding]; other site 692420006987 Switch I region; other site 692420006988 G2 box; other site 692420006989 G3 box; other site 692420006990 Switch II region; other site 692420006991 G4 box; other site 692420006992 G5 box; other site 692420006993 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 692420006994 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 692420006995 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 692420006996 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 692420006997 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 692420006998 stage II sporulation protein P; Region: spore_II_P; TIGR02867 692420006999 Germination protease; Region: Peptidase_A25; cl04057 692420007000 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 692420007001 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 692420007002 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 692420007003 YqzM-like protein; Region: YqzM; pfam14141 692420007004 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 692420007005 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 692420007006 Competence protein; Region: Competence; cl00471 692420007007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420007008 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 692420007009 catalytic motif [active] 692420007010 Zn binding site [ion binding]; other site 692420007011 SLBB domain; Region: SLBB; pfam10531 692420007012 comEA protein; Region: comE; TIGR01259 692420007013 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 692420007014 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 692420007015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007016 NAD(P) binding pocket [chemical binding]; other site 692420007017 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 692420007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007019 S-adenosylmethionine binding site [chemical binding]; other site 692420007020 Oligomerisation domain; Region: Oligomerisation; cl00519 692420007021 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 692420007022 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420007023 Zn2+ binding site [ion binding]; other site 692420007024 Mg2+ binding site [ion binding]; other site 692420007025 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 692420007026 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 692420007027 active site 692420007028 (T/H)XGH motif; other site 692420007029 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 692420007030 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 692420007031 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 692420007032 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 692420007033 shikimate binding site; other site 692420007034 NAD(P) binding site [chemical binding]; other site 692420007035 GTPase YqeH; Provisional; Region: PRK13796 692420007036 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 692420007037 GTP/Mg2+ binding site [chemical binding]; other site 692420007038 G4 box; other site 692420007039 G5 box; other site 692420007040 G1 box; other site 692420007041 Switch I region; other site 692420007042 G2 box; other site 692420007043 G3 box; other site 692420007044 Switch II region; other site 692420007045 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 692420007046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007047 active site 692420007048 motif I; other site 692420007049 motif II; other site 692420007050 Sporulation inhibitor A; Region: Sda; pfam08970 692420007051 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 692420007052 active site 692420007053 catalytic triad [active] 692420007054 oxyanion hole [active] 692420007055 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 692420007056 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420007057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007058 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420007059 putative substrate translocation pore; other site 692420007060 sporulation sigma factor SigK; Reviewed; Region: PRK05803 692420007061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420007062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420007063 DNA binding residues [nucleotide binding] 692420007064 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 692420007065 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 692420007066 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 692420007067 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 692420007068 putative active site [active] 692420007069 putative metal-binding site [ion binding]; other site 692420007070 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420007071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007072 NAD(P) binding site [chemical binding]; other site 692420007073 active site 692420007074 peptide synthase; Provisional; Region: PRK12316 692420007075 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420007076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007077 putative substrate translocation pore; other site 692420007078 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 692420007079 Glutamine amidotransferase class-I; Region: GATase; pfam00117 692420007080 glutamine binding [chemical binding]; other site 692420007081 catalytic triad [active] 692420007082 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 692420007083 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420007084 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 692420007085 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007086 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420007087 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007088 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420007089 Condensation domain; Region: Condensation; pfam00668 692420007090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420007091 Nonribosomal peptide synthase; Region: NRPS; pfam08415 692420007092 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007093 acyl-CoA synthetase; Validated; Region: PRK08308 692420007094 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420007095 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 692420007096 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 692420007097 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 692420007098 dimer interface [polypeptide binding]; other site 692420007099 glycine-pyridoxal phosphate binding site [chemical binding]; other site 692420007100 active site 692420007101 folate binding site [chemical binding]; other site 692420007102 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420007103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420007104 Predicted transcriptional regulator [Transcription]; Region: COG2378 692420007105 Helix-turn-helix domains; Region: HTH; cl00088 692420007106 WYL domain; Region: WYL; cl14852 692420007107 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 692420007108 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 692420007109 conserved cys residue [active] 692420007110 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 692420007111 similar to spoIIIC## fragment 692420007112 similar to hypothetical protein 692420007113 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 692420007114 aspartate racemase; Region: asp_race; TIGR00035 692420007115 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 692420007116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420007117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420007118 active site 692420007119 catalytic tetrad [active] 692420007120 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420007121 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 692420007122 DNA binding residues [nucleotide binding] 692420007123 putative dimer interface [polypeptide binding]; other site 692420007124 RecT family; Region: RecT; cl04285 692420007125 Domain of unknown function (DUF303); Region: DUF303; pfam03629 692420007126 potential frameshift: common BLAST hit: gi|150391618|ref|YP_001321667.1| PadR-like family transcriptional regulator 692420007127 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420007128 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 692420007129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420007130 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 692420007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420007133 putative substrate translocation pore; other site 692420007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420007136 Coenzyme A binding pocket [chemical binding]; other site 692420007137 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420007138 DinB superfamily; Region: DinB_2; pfam12867 692420007139 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420007140 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420007141 active site 692420007142 motif I; other site 692420007143 motif II; other site 692420007144 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420007145 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 692420007146 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420007147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007148 active site 692420007149 motif I; other site 692420007150 motif II; other site 692420007151 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420007152 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420007153 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420007154 putative active site [active] 692420007155 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420007156 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 692420007157 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 692420007158 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 692420007159 P-loop; other site 692420007160 active site 692420007161 phosphorylation site [posttranslational modification] 692420007162 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420007163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420007164 active site 692420007165 phosphorylation site [posttranslational modification] 692420007166 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420007167 Helix-turn-helix domains; Region: HTH; cl00088 692420007168 Helix-turn-helix domains; Region: HTH; cl00088 692420007169 PRD domain; Region: PRD; cl15445 692420007170 PRD domain; Region: PRD; cl15445 692420007171 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420007172 P-loop; other site 692420007173 active site 692420007174 phosphorylation site [posttranslational modification] 692420007175 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420007176 active site 692420007177 phosphorylation site [posttranslational modification] 692420007178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420007179 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 692420007180 putative deacylase active site [active] 692420007181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420007182 Helix-turn-helix domains; Region: HTH; cl00088 692420007183 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 692420007184 putative dimerization interface [polypeptide binding]; other site 692420007185 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420007186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007187 putative substrate translocation pore; other site 692420007188 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 692420007189 Cytochrome P450; Region: p450; pfam00067 692420007190 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 692420007191 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420007192 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 692420007193 FAD binding pocket [chemical binding]; other site 692420007194 FAD binding motif [chemical binding]; other site 692420007195 catalytic residues [active] 692420007196 NAD binding pocket [chemical binding]; other site 692420007197 phosphate binding motif [ion binding]; other site 692420007198 beta-alpha-beta structure motif; other site 692420007199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420007200 Helix-turn-helix domains; Region: HTH; cl00088 692420007201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007202 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 692420007203 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 692420007204 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 692420007205 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 692420007206 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 692420007207 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 692420007208 4Fe-4S binding domain; Region: Fer4; cl02805 692420007209 4Fe-4S binding domain; Region: Fer4; cl02805 692420007210 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 692420007211 [4Fe-4S] binding site [ion binding]; other site 692420007212 molybdopterin cofactor binding site; other site 692420007213 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 692420007214 molybdopterin cofactor binding site; other site 692420007215 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 692420007216 YrhC-like protein; Region: YrhC; pfam14143 692420007217 cystathionine beta-lyase; Provisional; Region: PRK07671 692420007218 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420007219 homodimer interface [polypeptide binding]; other site 692420007220 substrate-cofactor binding pocket; other site 692420007221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007222 catalytic residue [active] 692420007223 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420007224 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420007225 dimer interface [polypeptide binding]; other site 692420007226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007227 catalytic residue [active] 692420007228 5'-methylthioadenosine nucleosidase; Region: PLN02584 692420007229 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 692420007230 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 692420007231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007232 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 692420007233 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 692420007234 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420007235 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420007236 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420007237 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 692420007238 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 692420007239 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 692420007240 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 692420007241 ATP-binding site [chemical binding]; other site 692420007242 Sugar specificity; other site 692420007243 Pyrimidine base specificity; other site 692420007244 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 692420007245 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 692420007246 Peptidase family U32; Region: Peptidase_U32; cl03113 692420007247 Peptidase family U32; Region: Peptidase_U32; cl03113 692420007248 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 692420007249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007250 S-adenosylmethionine binding site [chemical binding]; other site 692420007251 YceG-like family; Region: YceG; pfam02618 692420007252 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 692420007253 dimerization interface [polypeptide binding]; other site 692420007254 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 692420007255 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 692420007256 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 692420007257 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 692420007258 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 692420007259 motif 1; other site 692420007260 active site 692420007261 motif 2; other site 692420007262 motif 3; other site 692420007263 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 692420007264 DHHA1 domain; Region: DHHA1; pfam02272 692420007265 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420007266 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420007267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420007268 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 692420007269 Walker A/P-loop; other site 692420007270 ATP binding site [chemical binding]; other site 692420007271 Q-loop/lid; other site 692420007272 ABC transporter signature motif; other site 692420007273 Walker B; other site 692420007274 D-loop; other site 692420007275 H-loop/switch region; other site 692420007276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420007277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420007278 substrate binding pocket [chemical binding]; other site 692420007279 membrane-bound complex binding site; other site 692420007280 hinge residues; other site 692420007281 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420007282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007283 dimer interface [polypeptide binding]; other site 692420007284 conserved gate region; other site 692420007285 putative PBP binding loops; other site 692420007286 ABC-ATPase subunit interface; other site 692420007287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007288 dimer interface [polypeptide binding]; other site 692420007289 conserved gate region; other site 692420007290 putative PBP binding loops; other site 692420007291 ABC-ATPase subunit interface; other site 692420007292 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 692420007293 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 692420007294 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420007295 Family description; Region: UvrD_C_2; cl15862 692420007296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007297 binding surface 692420007298 TPR motif; other site 692420007299 TPR repeat; Region: TPR_11; pfam13414 692420007300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007301 binding surface 692420007302 TPR motif; other site 692420007303 TPR repeat; Region: TPR_11; pfam13414 692420007304 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 692420007305 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 692420007306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420007307 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 692420007308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420007309 catalytic residue [active] 692420007310 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420007311 Helix-turn-helix domains; Region: HTH; cl00088 692420007312 recombination factor protein RarA; Reviewed; Region: PRK13342 692420007313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007314 Walker A motif; other site 692420007315 ATP binding site [chemical binding]; other site 692420007316 Walker B motif; other site 692420007317 arginine finger; other site 692420007318 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 692420007319 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 692420007320 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 692420007321 putative ATP binding site [chemical binding]; other site 692420007322 putative substrate interface [chemical binding]; other site 692420007323 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 692420007324 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 692420007325 dimer interface [polypeptide binding]; other site 692420007326 anticodon binding site; other site 692420007327 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 692420007328 homodimer interface [polypeptide binding]; other site 692420007329 motif 1; other site 692420007330 active site 692420007331 motif 2; other site 692420007332 GAD domain; Region: GAD; pfam02938 692420007333 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 692420007334 active site 692420007335 motif 3; other site 692420007336 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 692420007337 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 692420007338 dimer interface [polypeptide binding]; other site 692420007339 motif 1; other site 692420007340 active site 692420007341 motif 2; other site 692420007342 motif 3; other site 692420007343 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 692420007344 anticodon binding site; other site 692420007345 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 692420007346 Bacterial SH3 domain; Region: SH3_3; cl02551 692420007347 Bacterial SH3 domain; Region: SH3_3; cl02551 692420007348 Bacterial SH3 domain; Region: SH3_3; cl02551 692420007349 Bacterial SH3 domain; Region: SH3_3; cl02551 692420007350 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420007351 active site 692420007352 metal binding site [ion binding]; metal-binding site 692420007353 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 692420007354 putative active site [active] 692420007355 dimerization interface [polypeptide binding]; other site 692420007356 putative tRNAtyr binding site [nucleotide binding]; other site 692420007357 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 692420007358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 692420007359 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420007360 synthetase active site [active] 692420007361 NTP binding site [chemical binding]; other site 692420007362 metal binding site [ion binding]; metal-binding site 692420007363 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 692420007364 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 692420007365 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 692420007366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420007367 active site 692420007368 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 692420007369 DHH family; Region: DHH; pfam01368 692420007370 DHHA1 domain; Region: DHHA1; pfam02272 692420007371 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 692420007372 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 692420007373 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 692420007374 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 692420007375 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 692420007376 Protein export membrane protein; Region: SecD_SecF; cl14618 692420007377 Protein export membrane protein; Region: SecD_SecF; cl14618 692420007378 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 692420007379 stage V sporulation protein B; Region: spore_V_B; TIGR02900 692420007380 MatE; Region: MatE; cl10513 692420007381 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420007382 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 692420007383 Preprotein translocase subunit; Region: YajC; cl00806 692420007384 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 692420007385 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 692420007386 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 692420007387 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 692420007388 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 692420007389 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 692420007390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007391 Walker A motif; other site 692420007392 ATP binding site [chemical binding]; other site 692420007393 Walker B motif; other site 692420007394 arginine finger; other site 692420007395 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 692420007396 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 692420007397 RuvA N terminal domain; Region: RuvA_N; pfam01330 692420007398 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 692420007399 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 692420007400 BofC C-terminal domain; Region: BofC_C; pfam08955 692420007401 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420007402 similar to fragment spore cortex protein B. subtilis 692420007403 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420007404 putative peptidoglycan binding site; other site 692420007405 Quinolinate synthetase A protein; Region: NadA; cl00420 692420007406 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 692420007407 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 692420007408 dimerization interface [polypeptide binding]; other site 692420007409 active site 692420007410 L-aspartate oxidase; Provisional; Region: PRK08071 692420007411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007412 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 692420007413 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420007414 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 692420007415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420007416 catalytic residue [active] 692420007417 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 692420007418 Helix-turn-helix domains; Region: HTH; cl00088 692420007419 3H domain; Region: 3H; pfam02829 692420007420 prephenate dehydratase; Provisional; Region: PRK11898 692420007421 Prephenate dehydratase; Region: PDT; pfam00800 692420007422 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 692420007423 putative L-Phe binding site [chemical binding]; other site 692420007424 hypothetical protein; Provisional; Region: PRK04435 692420007425 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 692420007426 GTPase CgtA; Reviewed; Region: obgE; PRK12297 692420007427 GTP1/OBG; Region: GTP1_OBG; pfam01018 692420007428 Obg GTPase; Region: Obg; cd01898 692420007429 G1 box; other site 692420007430 GTP/Mg2+ binding site [chemical binding]; other site 692420007431 Switch I region; other site 692420007432 G2 box; other site 692420007433 G3 box; other site 692420007434 Switch II region; other site 692420007435 G4 box; other site 692420007436 G5 box; other site 692420007437 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 692420007438 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420007439 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 692420007440 Protein of unknown function (DUF464); Region: DUF464; cl01080 692420007441 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 692420007442 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 692420007443 active site 692420007444 putative substrate binding region [chemical binding]; other site 692420007445 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420007446 septum site-determining protein MinD; Region: minD_bact; TIGR01968 692420007447 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 692420007448 Switch I; other site 692420007449 Switch II; other site 692420007450 septum formation inhibitor; Reviewed; Region: minC; PRK00513 692420007451 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 692420007452 rod shape-determining protein MreD; Region: MreD; cl01087 692420007453 rod shape-determining protein MreC; Region: mreC; TIGR00219 692420007454 rod shape-determining protein MreC; Region: MreC; pfam04085 692420007455 rod shape-determining protein MreB; Provisional; Region: PRK13927 692420007456 Cell division protein FtsA; Region: FtsA; cl11496 692420007457 hypothetical protein; Reviewed; Region: PRK00024 692420007458 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 692420007459 MPN+ (JAMM) motif; other site 692420007460 Zinc-binding site [ion binding]; other site 692420007461 Maf-like protein; Region: Maf; pfam02545 692420007462 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 692420007463 active site 692420007464 dimer interface [polypeptide binding]; other site 692420007465 Sporulation related domain; Region: SPOR; cl10051 692420007466 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 692420007467 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 692420007468 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 692420007469 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 692420007470 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420007471 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420007472 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 692420007473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 692420007474 active site 692420007475 HIGH motif; other site 692420007476 nucleotide binding site [chemical binding]; other site 692420007477 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420007478 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 692420007479 active site 692420007480 KMSKS motif; other site 692420007481 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 692420007482 tRNA binding surface [nucleotide binding]; other site 692420007483 anticodon binding site; other site 692420007484 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 692420007485 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420007486 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 692420007487 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 692420007488 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 692420007489 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 692420007490 putative peptidoglycan binding site; other site 692420007491 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 692420007492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420007493 inhibitor-cofactor binding pocket; inhibition site 692420007494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007495 catalytic residue [active] 692420007496 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 692420007497 dimer interface [polypeptide binding]; other site 692420007498 active site 692420007499 Schiff base residues; other site 692420007500 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420007501 active site 692420007502 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 692420007503 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 692420007504 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 692420007505 domain interfaces; other site 692420007506 active site 692420007507 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 692420007508 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 692420007509 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 692420007510 tRNA; other site 692420007511 putative tRNA binding site [nucleotide binding]; other site 692420007512 putative NADP binding site [chemical binding]; other site 692420007513 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 692420007514 Predicted GTPase [General function prediction only]; Region: COG0218 692420007515 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 692420007516 G1 box; other site 692420007517 GTP/Mg2+ binding site [chemical binding]; other site 692420007518 Switch I region; other site 692420007519 G2 box; other site 692420007520 G3 box; other site 692420007521 Switch II region; other site 692420007522 G4 box; other site 692420007523 G5 box; other site 692420007524 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 692420007525 Found in ATP-dependent protease La (LON); Region: LON; smart00464 692420007526 Found in ATP-dependent protease La (LON); Region: LON; smart00464 692420007527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007528 Walker A motif; other site 692420007529 ATP binding site [chemical binding]; other site 692420007530 Walker B motif; other site 692420007531 arginine finger; other site 692420007532 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 692420007533 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 692420007534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007535 Walker A motif; other site 692420007536 ATP binding site [chemical binding]; other site 692420007537 Walker B motif; other site 692420007538 arginine finger; other site 692420007539 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 692420007540 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 692420007541 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 692420007542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007543 Walker A motif; other site 692420007544 ATP binding site [chemical binding]; other site 692420007545 Walker B motif; other site 692420007546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 692420007547 trigger factor; Provisional; Region: tig; PRK01490 692420007548 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 692420007549 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 692420007550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007551 binding surface 692420007552 TPR motif; other site 692420007553 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 692420007554 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 692420007555 substrate binding site [chemical binding]; other site 692420007556 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 692420007557 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 692420007558 substrate binding site [chemical binding]; other site 692420007559 ligand binding site [chemical binding]; other site 692420007560 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 692420007561 tartrate dehydrogenase; Provisional; Region: PRK08194 692420007562 2-isopropylmalate synthase; Validated; Region: PRK00915 692420007563 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 692420007564 active site 692420007565 catalytic residues [active] 692420007566 metal binding site [ion binding]; metal-binding site 692420007567 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 692420007568 ketol-acid reductoisomerase; Provisional; Region: PRK05479 692420007569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 692420007571 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 692420007572 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 692420007573 putative valine binding site [chemical binding]; other site 692420007574 dimer interface [polypeptide binding]; other site 692420007575 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 692420007576 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 692420007577 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420007578 PYR/PP interface [polypeptide binding]; other site 692420007579 dimer interface [polypeptide binding]; other site 692420007580 TPP binding site [chemical binding]; other site 692420007581 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 692420007582 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 692420007583 TPP-binding site [chemical binding]; other site 692420007584 dimer interface [polypeptide binding]; other site 692420007585 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 692420007586 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420007587 active site 692420007588 metal binding site [ion binding]; metal-binding site 692420007589 homotetramer interface [polypeptide binding]; other site 692420007590 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 692420007591 active site 692420007592 dimerization interface [polypeptide binding]; other site 692420007593 ribonuclease PH; Reviewed; Region: rph; PRK00173 692420007594 Ribonuclease PH; Region: RNase_PH_bact; cd11362 692420007595 hexamer interface [polypeptide binding]; other site 692420007596 active site 692420007597 Sporulation and spore germination; Region: Germane; cl11253 692420007598 Spore germination protein [General function prediction only]; Region: COG5401 692420007599 Sporulation and spore germination; Region: Germane; cl11253 692420007600 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 692420007601 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420007602 Helix-turn-helix domains; Region: HTH; cl00088 692420007603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420007604 DNA binding residues [nucleotide binding] 692420007605 dimerization interface [polypeptide binding]; other site 692420007606 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 692420007607 active site 692420007608 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 692420007609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 692420007610 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 692420007611 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 692420007612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007613 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 692420007614 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 692420007615 putative Iron-sulfur protein interface [polypeptide binding]; other site 692420007616 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 692420007617 proximal heme binding site [chemical binding]; other site 692420007618 distal heme binding site [chemical binding]; other site 692420007619 putative dimer interface [polypeptide binding]; other site 692420007620 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 692420007621 aspartate kinase; Reviewed; Region: PRK06635 692420007622 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 692420007623 putative nucleotide binding site [chemical binding]; other site 692420007624 putative catalytic residues [active] 692420007625 putative Mg ion binding site [ion binding]; other site 692420007626 putative aspartate binding site [chemical binding]; other site 692420007627 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 692420007628 putative allosteric regulatory site; other site 692420007629 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 692420007630 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 692420007631 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 692420007632 GIY-YIG motif/motif A; other site 692420007633 active site 692420007634 catalytic site [active] 692420007635 putative DNA binding site [nucleotide binding]; other site 692420007636 metal binding site [ion binding]; metal-binding site 692420007637 UvrB/uvrC motif; Region: UVR; pfam02151 692420007638 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 692420007639 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420007640 catalytic residues [active] 692420007641 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 692420007642 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 692420007643 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 692420007644 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 692420007645 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 692420007646 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 692420007647 Ligand binding site [chemical binding]; other site 692420007648 Electron transfer flavoprotein domain; Region: ETF; pfam01012 692420007649 enoyl-CoA hydratase; Provisional; Region: PRK07658 692420007650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420007651 substrate binding site [chemical binding]; other site 692420007652 oxyanion hole (OAH) forming residues; other site 692420007653 trimer interface [polypeptide binding]; other site 692420007654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420007655 Helix-turn-helix domains; Region: HTH; cl00088 692420007656 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 692420007657 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 692420007658 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007659 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007660 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 692420007661 Predicted membrane protein [Function unknown]; Region: COG3766 692420007662 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 692420007663 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 692420007664 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 692420007665 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 692420007666 Walker A/P-loop; other site 692420007667 ATP binding site [chemical binding]; other site 692420007668 Q-loop/lid; other site 692420007669 ABC transporter signature motif; other site 692420007670 Walker B; other site 692420007671 D-loop; other site 692420007672 H-loop/switch region; other site 692420007673 Smr domain; Region: Smr; cl02619 692420007674 hypothetical protein; Provisional; Region: PRK08609 692420007675 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 692420007676 active site 692420007677 primer binding site [nucleotide binding]; other site 692420007678 NTP binding site [chemical binding]; other site 692420007679 metal binding triad [ion binding]; metal-binding site 692420007680 Colicin V production protein; Region: Colicin_V; cl00567 692420007681 Cell division protein ZapA; Region: ZapA; cl01146 692420007682 ribonuclease HIII; Provisional; Region: PRK00996 692420007683 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 692420007684 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 692420007685 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420007686 active site 692420007687 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 692420007688 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 692420007689 putative tRNA-binding site [nucleotide binding]; other site 692420007690 B3/4 domain; Region: B3_4; cl11458 692420007691 tRNA synthetase B5 domain; Region: B5; cl08394 692420007692 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 692420007693 dimer interface [polypeptide binding]; other site 692420007694 motif 1; other site 692420007695 motif 3; other site 692420007696 motif 2; other site 692420007697 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 692420007698 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 692420007699 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 692420007700 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 692420007701 dimer interface [polypeptide binding]; other site 692420007702 motif 1; other site 692420007703 active site 692420007704 motif 2; other site 692420007705 motif 3; other site 692420007706 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 692420007707 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 692420007708 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 692420007709 Small, acid-soluble spore protein I; Region: SSPI; cl07940 692420007710 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 692420007711 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 692420007712 Helix-turn-helix domains; Region: HTH; cl00088 692420007713 FAD binding domain; Region: FAD_binding_4; pfam01565 692420007714 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 692420007715 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 692420007716 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 692420007717 Cysteine-rich domain; Region: CCG; pfam02754 692420007718 Cysteine-rich domain; Region: CCG; pfam02754 692420007719 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 692420007720 Carbon starvation protein CstA; Region: CstA; pfam02554 692420007721 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 692420007722 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 692420007723 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 692420007724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007725 dimer interface [polypeptide binding]; other site 692420007726 conserved gate region; other site 692420007727 putative PBP binding loops; other site 692420007728 ABC-ATPase subunit interface; other site 692420007729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007730 dimer interface [polypeptide binding]; other site 692420007731 conserved gate region; other site 692420007732 putative PBP binding loops; other site 692420007733 ABC-ATPase subunit interface; other site 692420007734 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 692420007735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420007736 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 692420007737 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 692420007738 active site 692420007739 metal binding site [ion binding]; metal-binding site 692420007740 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 692420007741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007742 active site 692420007743 motif I; other site 692420007744 motif II; other site 692420007745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007746 motif II; other site 692420007747 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 692420007748 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 692420007749 intersubunit interface [polypeptide binding]; other site 692420007750 active site 692420007751 Zn2+ binding site [ion binding]; other site 692420007752 ribulokinase; Provisional; Region: PRK04123 692420007753 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 692420007754 putative N- and C-terminal domain interface [polypeptide binding]; other site 692420007755 putative active site [active] 692420007756 putative MgATP binding site [chemical binding]; other site 692420007757 catalytic site [active] 692420007758 metal binding site [ion binding]; metal-binding site 692420007759 carbohydrate binding site [chemical binding]; other site 692420007760 homodimer interface [polypeptide binding]; other site 692420007761 L-arabinose isomerase; Provisional; Region: PRK02929 692420007762 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 692420007763 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 692420007764 trimer interface [polypeptide binding]; other site 692420007765 putative substrate binding site [chemical binding]; other site 692420007766 putative metal binding site [ion binding]; other site 692420007767 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 692420007768 substrate binding site [chemical binding]; other site 692420007769 active site 692420007770 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420007771 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 692420007772 oligomer interface [polypeptide binding]; other site 692420007773 active site 692420007774 metal binding site [ion binding]; metal-binding site 692420007775 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 692420007776 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 692420007777 23S rRNA binding site [nucleotide binding]; other site 692420007778 L21 binding site [polypeptide binding]; other site 692420007779 L13 binding site [polypeptide binding]; other site 692420007780 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 692420007781 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 692420007782 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 692420007783 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 692420007784 LrgB-like family; Region: LrgB; cl00596 692420007785 LrgA family; Region: LrgA; cl00608 692420007786 two-component response regulator; Provisional; Region: PRK14084 692420007787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420007788 active site 692420007789 phosphorylation site [posttranslational modification] 692420007790 intermolecular recognition site; other site 692420007791 dimerization interface [polypeptide binding]; other site 692420007792 LytTr DNA-binding domain; Region: LytTR; cl04498 692420007793 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 692420007794 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420007795 GAF domain; Region: GAF; cl15785 692420007796 Histidine kinase; Region: His_kinase; pfam06580 692420007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420007798 ATP binding site [chemical binding]; other site 692420007799 Mg2+ binding site [ion binding]; other site 692420007800 G-X-G motif; other site 692420007801 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 692420007802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007803 motif II; other site 692420007804 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 692420007805 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 692420007806 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 692420007807 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 692420007808 active site 692420007809 dimer interface [polypeptide binding]; other site 692420007810 motif 1; other site 692420007811 motif 2; other site 692420007812 motif 3; other site 692420007813 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 692420007814 anticodon binding site; other site 692420007815 YtxC-like family; Region: YtxC; cl08500 692420007816 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 692420007817 primosomal protein DnaI; Reviewed; Region: PRK08939 692420007818 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 692420007819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007820 Walker A motif; other site 692420007821 ATP binding site [chemical binding]; other site 692420007822 Walker B motif; other site 692420007823 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 692420007824 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 692420007825 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 692420007826 ATP cone domain; Region: ATP-cone; pfam03477 692420007827 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 692420007828 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 692420007829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007830 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 692420007831 Helix-turn-helix domains; Region: HTH; cl00088 692420007832 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420007833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007834 putative substrate translocation pore; other site 692420007835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420007836 active site 692420007837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420007838 catalytic tetrad [active] 692420007839 dephospho-CoA kinase; Region: TIGR00152 692420007840 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 692420007841 CoA-binding site [chemical binding]; other site 692420007842 ATP-binding [chemical binding]; other site 692420007843 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 692420007844 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 692420007845 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 692420007846 DNA binding site [nucleotide binding] 692420007847 catalytic residue [active] 692420007848 H2TH interface [polypeptide binding]; other site 692420007849 putative catalytic residues [active] 692420007850 turnover-facilitating residue; other site 692420007851 intercalation triad [nucleotide binding]; other site 692420007852 8OG recognition residue [nucleotide binding]; other site 692420007853 putative reading head residues; other site 692420007854 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 692420007855 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 692420007856 DNA polymerase I; Provisional; Region: PRK05755 692420007857 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 692420007858 active site 692420007859 metal binding site 1 [ion binding]; metal-binding site 692420007860 putative 5' ssDNA interaction site; other site 692420007861 metal binding site 3; metal-binding site 692420007862 metal binding site 2 [ion binding]; metal-binding site 692420007863 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 692420007864 putative DNA binding site [nucleotide binding]; other site 692420007865 putative metal binding site [ion binding]; other site 692420007866 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 692420007867 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 692420007868 active site 692420007869 DNA binding site [nucleotide binding] 692420007870 catalytic site [active] 692420007871 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 692420007872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420007873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420007874 dimer interface [polypeptide binding]; other site 692420007875 phosphorylation site [posttranslational modification] 692420007876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420007877 ATP binding site [chemical binding]; other site 692420007878 Mg2+ binding site [ion binding]; other site 692420007879 G-X-G motif; other site 692420007880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420007881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420007882 active site 692420007883 phosphorylation site [posttranslational modification] 692420007884 intermolecular recognition site; other site 692420007885 dimerization interface [polypeptide binding]; other site 692420007886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420007887 DNA binding site [nucleotide binding] 692420007888 malate dehydrogenase; Reviewed; Region: PRK06223 692420007889 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 692420007890 NAD(P) binding site [chemical binding]; other site 692420007891 dimer interface [polypeptide binding]; other site 692420007892 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420007893 substrate binding site [chemical binding]; other site 692420007894 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 692420007895 isocitrate dehydrogenase; Validated; Region: PRK07362 692420007896 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 692420007897 dimer interface [polypeptide binding]; other site 692420007898 Citrate synthase; Region: Citrate_synt; pfam00285 692420007899 active site 692420007900 citrylCoA binding site [chemical binding]; other site 692420007901 oxalacetate/citrate binding site [chemical binding]; other site 692420007902 coenzyme A binding site [chemical binding]; other site 692420007903 catalytic triad [active] 692420007904 Protein of unknown function (DUF441); Region: DUF441; cl01041 692420007905 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420007906 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420007907 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 692420007908 pyruvate kinase; Provisional; Region: PRK06354 692420007909 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 692420007910 domain interfaces; other site 692420007911 active site 692420007912 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 692420007913 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 692420007914 active site 692420007915 ADP/pyrophosphate binding site [chemical binding]; other site 692420007916 dimerization interface [polypeptide binding]; other site 692420007917 allosteric effector site; other site 692420007918 fructose-1,6-bisphosphate binding site; other site 692420007919 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420007920 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 692420007921 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 692420007922 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 692420007923 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 692420007924 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 692420007925 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420007926 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 692420007927 putative NAD(P) binding site [chemical binding]; other site 692420007928 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 692420007929 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 692420007930 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 692420007931 generic binding surface I; other site 692420007932 generic binding surface II; other site 692420007933 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 692420007934 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 692420007935 DHH family; Region: DHH; pfam01368 692420007936 DHHA1 domain; Region: DHHA1; pfam02272 692420007937 YtpI-like protein; Region: YtpI; pfam14007 692420007938 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 692420007939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420007940 DNA-binding site [nucleotide binding]; DNA binding site 692420007941 DRTGG domain; Region: DRTGG; cl12147 692420007942 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 692420007943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 692420007944 active site 2 [active] 692420007945 active site 1 [active] 692420007946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420007947 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420007948 classical (c) SDRs; Region: SDR_c; cd05233 692420007949 NAD(P) binding site [chemical binding]; other site 692420007950 active site 692420007951 argininosuccinate lyase; Provisional; Region: PRK00855 692420007952 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 692420007953 active sites [active] 692420007954 tetramer interface [polypeptide binding]; other site 692420007955 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 692420007956 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 692420007957 ANP binding site [chemical binding]; other site 692420007958 Substrate Binding Site II [chemical binding]; other site 692420007959 Substrate Binding Site I [chemical binding]; other site 692420007960 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 692420007961 MPT binding site; other site 692420007962 trimer interface [polypeptide binding]; other site 692420007963 Acetokinase family; Region: Acetate_kinase; cl01029 692420007964 propionate/acetate kinase; Provisional; Region: PRK12379 692420007965 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 692420007966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007967 S-adenosylmethionine binding site [chemical binding]; other site 692420007968 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 692420007969 dimer interface [polypeptide binding]; other site 692420007970 catalytic triad [active] 692420007971 peroxidatic and resolving cysteines [active] 692420007972 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 692420007973 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 692420007974 RDD family; Region: RDD; cl00746 692420007975 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 692420007976 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 692420007977 tandem repeat interface [polypeptide binding]; other site 692420007978 oligomer interface [polypeptide binding]; other site 692420007979 active site residues [active] 692420007980 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 692420007981 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 692420007982 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 692420007983 active site 692420007984 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 692420007985 AMP-binding enzyme; Region: AMP-binding; cl15778 692420007986 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420007987 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420007988 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 692420007989 THUMP domain; Region: THUMP; cl12076 692420007990 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 692420007991 Ligand Binding Site [chemical binding]; other site 692420007992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420007993 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 692420007994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420007995 catalytic residue [active] 692420007996 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 692420007997 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 692420007998 TMPIT-like protein; Region: TMPIT; pfam07851 692420007999 histidinol-phosphatase; Reviewed; Region: PRK08123 692420008000 PHP-associated; Region: PHP_C; pfam13263 692420008001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420008002 Helix-turn-helix domains; Region: HTH; cl00088 692420008003 GAF domain; Region: GAF; cl15785 692420008004 GAF domain; Region: GAF_2; pfam13185 692420008005 GAF domain; Region: GAF; cl15785 692420008006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420008007 metal binding site [ion binding]; metal-binding site 692420008008 active site 692420008009 I-site; other site 692420008010 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 692420008011 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 692420008012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008013 RNA binding surface [nucleotide binding]; other site 692420008014 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 692420008015 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 692420008016 heme-binding site [chemical binding]; other site 692420008017 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 692420008018 FAD binding pocket [chemical binding]; other site 692420008019 FAD binding motif [chemical binding]; other site 692420008020 phosphate binding motif [ion binding]; other site 692420008021 beta-alpha-beta structure motif; other site 692420008022 NAD binding pocket [chemical binding]; other site 692420008023 Heme binding pocket [chemical binding]; other site 692420008024 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 692420008025 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 692420008026 active site 692420008027 catalytic triad [active] 692420008028 oxyanion hole [active] 692420008029 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420008030 Cation efflux family; Region: Cation_efflux; cl00316 692420008031 Predicted transcriptional regulators [Transcription]; Region: COG1378 692420008032 Helix-turn-helix domains; Region: HTH; cl00088 692420008033 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 692420008034 C-terminal domain interface [polypeptide binding]; other site 692420008035 sugar binding site [chemical binding]; other site 692420008036 AzlC protein; Region: AzlC; cl00570 692420008037 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 692420008038 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 692420008039 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 692420008040 active site 692420008041 HIGH motif; other site 692420008042 dimer interface [polypeptide binding]; other site 692420008043 KMSKS motif; other site 692420008044 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008045 RNA binding surface [nucleotide binding]; other site 692420008046 acetyl-CoA synthetase; Provisional; Region: PRK04319 692420008047 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 692420008048 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008049 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420008050 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420008051 FOG: CBS domain [General function prediction only]; Region: COG0517 692420008052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 692420008053 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 692420008054 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 692420008055 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 692420008056 flagellar motor protein MotS; Reviewed; Region: PRK06925 692420008057 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 692420008058 ligand binding site [chemical binding]; other site 692420008059 flagellar motor protein MotP; Reviewed; Region: PRK06926 692420008060 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 692420008061 catabolite control protein A; Region: ccpA; TIGR01481 692420008062 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420008063 DNA binding site [nucleotide binding] 692420008064 domain linker motif; other site 692420008065 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 692420008066 dimerization interface [polypeptide binding]; other site 692420008067 effector binding site; other site 692420008068 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 692420008069 Chorismate mutase type II; Region: CM_2; cl00693 692420008070 NeuB family; Region: NeuB; cl00496 692420008071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 692420008072 YtxH-like protein; Region: YtxH; cl02079 692420008073 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 692420008074 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 692420008075 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420008076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420008077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420008078 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 692420008079 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420008080 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 692420008081 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 692420008082 putative tRNA-binding site [nucleotide binding]; other site 692420008083 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 692420008084 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420008085 catalytic residues [active] 692420008086 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 692420008087 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420008088 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 692420008089 oligomer interface [polypeptide binding]; other site 692420008090 active site 692420008091 metal binding site [ion binding]; metal-binding site 692420008092 Predicted small secreted protein [Function unknown]; Region: COG5584 692420008093 potential frameshift: common BLAST hit: gi|154687127|ref|YP_001422288.1| malate dehydrogenase 692420008094 similar to MalS fragment; 'intermediary metabolism; Metabolism of carbohydrates and related molecules; TCA cycle' 692420008095 similar to malate oxidoreductase fragment; Malic enzyme, N-terminal 692420008096 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420008097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420008098 S-adenosylmethionine binding site [chemical binding]; other site 692420008099 YtzH-like protein; Region: YtzH; pfam14165 692420008100 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 692420008101 active site 692420008102 substrate binding site [chemical binding]; other site 692420008103 ATP binding site [chemical binding]; other site 692420008104 Phosphotransferase enzyme family; Region: APH; pfam01636 692420008105 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 692420008106 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 692420008107 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 692420008108 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420008109 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420008110 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420008111 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420008112 dimer interface [polypeptide binding]; other site 692420008113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008114 catalytic residue [active] 692420008115 dipeptidase PepV; Reviewed; Region: PRK07318 692420008116 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 692420008117 active site 692420008118 metal binding site [ion binding]; metal-binding site 692420008119 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 692420008120 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 692420008121 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420008122 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 692420008123 Walker A/P-loop; other site 692420008124 ATP binding site [chemical binding]; other site 692420008125 Q-loop/lid; other site 692420008126 ABC transporter signature motif; other site 692420008127 Walker B; other site 692420008128 D-loop; other site 692420008129 H-loop/switch region; other site 692420008130 Helix-turn-helix domains; Region: HTH; cl00088 692420008131 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420008132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008133 RNA binding surface [nucleotide binding]; other site 692420008134 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 692420008135 active site 692420008136 uracil binding [chemical binding]; other site 692420008137 stage V sporulation protein B; Region: spore_V_B; TIGR02900 692420008138 MatE; Region: MatE; cl10513 692420008139 MatE; Region: MatE; cl10513 692420008140 HI0933-like protein; Region: HI0933_like; pfam03486 692420008141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008143 BCCT family transporter; Region: BCCT; cl00569 692420008144 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 692420008145 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420008146 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 692420008147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420008148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420008149 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 692420008150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008151 dimer interface [polypeptide binding]; other site 692420008152 conserved gate region; other site 692420008153 putative PBP binding loops; other site 692420008154 ABC-ATPase subunit interface; other site 692420008155 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 692420008156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008157 dimer interface [polypeptide binding]; other site 692420008158 conserved gate region; other site 692420008159 putative PBP binding loops; other site 692420008160 ABC-ATPase subunit interface; other site 692420008161 alpha-galactosidase; Provisional; Region: PRK15076 692420008162 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 692420008163 NAD binding site [chemical binding]; other site 692420008164 sugar binding site [chemical binding]; other site 692420008165 divalent metal binding site [ion binding]; other site 692420008166 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420008167 dimer interface [polypeptide binding]; other site 692420008168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420008169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420008170 Coenzyme A binding pocket [chemical binding]; other site 692420008171 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 692420008172 active site residue [active] 692420008173 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 692420008174 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 692420008175 HIGH motif; other site 692420008176 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420008177 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 692420008178 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 692420008179 active site 692420008180 KMSKS motif; other site 692420008181 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 692420008182 tRNA binding surface [nucleotide binding]; other site 692420008183 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 692420008184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420008185 PAS domain; Region: PAS_9; pfam13426 692420008186 putative active site [active] 692420008187 heme pocket [chemical binding]; other site 692420008188 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420008189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420008191 putative substrate translocation pore; other site 692420008192 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 692420008193 FtsX-like permease family; Region: FtsX; cl15850 692420008194 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420008195 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 692420008196 Walker A/P-loop; other site 692420008197 ATP binding site [chemical binding]; other site 692420008198 Q-loop/lid; other site 692420008199 ABC transporter signature motif; other site 692420008200 Walker B; other site 692420008201 D-loop; other site 692420008202 H-loop/switch region; other site 692420008203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 692420008204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008205 ATP binding site [chemical binding]; other site 692420008206 Mg2+ binding site [ion binding]; other site 692420008207 G-X-G motif; other site 692420008208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420008209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008210 active site 692420008211 phosphorylation site [posttranslational modification] 692420008212 intermolecular recognition site; other site 692420008213 dimerization interface [polypeptide binding]; other site 692420008214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420008215 DNA binding site [nucleotide binding] 692420008216 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420008217 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420008218 FtsX-like permease family; Region: FtsX; cl15850 692420008219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420008220 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 692420008221 Walker A/P-loop; other site 692420008222 ATP binding site [chemical binding]; other site 692420008223 Q-loop/lid; other site 692420008224 ABC transporter signature motif; other site 692420008225 Walker B; other site 692420008226 D-loop; other site 692420008227 H-loop/switch region; other site 692420008228 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420008229 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420008230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420008231 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 692420008232 Walker A/P-loop; other site 692420008233 ATP binding site [chemical binding]; other site 692420008234 Q-loop/lid; other site 692420008235 ABC transporter signature motif; other site 692420008236 Walker B; other site 692420008237 D-loop; other site 692420008238 H-loop/switch region; other site 692420008239 Predicted transcriptional regulators [Transcription]; Region: COG1725 692420008240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420008241 DNA-binding site [nucleotide binding]; DNA binding site 692420008242 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 692420008243 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 692420008244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008245 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 692420008246 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 692420008247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008249 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 692420008250 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 692420008251 trimer interface [polypeptide binding]; other site 692420008252 putative metal binding site [ion binding]; other site 692420008253 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420008254 Spore germination protein; Region: Spore_permease; cl15802 692420008255 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 692420008256 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 692420008257 active site 692420008258 dimer interface [polypeptide binding]; other site 692420008259 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 692420008260 Ligand Binding Site [chemical binding]; other site 692420008261 Molecular Tunnel; other site 692420008262 S-adenosylmethionine synthetase; Validated; Region: PRK05250 692420008263 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 692420008264 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 692420008265 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 692420008266 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 692420008267 active site 692420008268 substrate-binding site [chemical binding]; other site 692420008269 metal-binding site [ion binding] 692420008270 ATP binding site [chemical binding]; other site 692420008271 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 692420008272 Dienelactone hydrolase family; Region: DLH; pfam01738 692420008273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008274 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 692420008275 NMT1-like family; Region: NMT1_2; cl15260 692420008276 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 692420008277 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 692420008278 Walker A/P-loop; other site 692420008279 ATP binding site [chemical binding]; other site 692420008280 Q-loop/lid; other site 692420008281 ABC transporter signature motif; other site 692420008282 Walker B; other site 692420008283 D-loop; other site 692420008284 H-loop/switch region; other site 692420008285 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 692420008286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008287 dimer interface [polypeptide binding]; other site 692420008288 conserved gate region; other site 692420008289 putative PBP binding loops; other site 692420008290 ABC-ATPase subunit interface; other site 692420008291 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 692420008292 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 692420008293 nudix motif; other site 692420008294 Holin family; Region: Phage_holin_4; cl01989 692420008295 Ferritin-like domain; Region: Ferritin; pfam00210 692420008296 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 692420008297 dimerization interface [polypeptide binding]; other site 692420008298 DPS ferroxidase diiron center [ion binding]; other site 692420008299 ion pore; other site 692420008300 FixH; Region: FixH; cl01254 692420008301 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 692420008302 Haemolytic domain; Region: Haemolytic; cl00506 692420008303 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 692420008304 active site clefts [active] 692420008305 zinc binding site [ion binding]; other site 692420008306 dimer interface [polypeptide binding]; other site 692420008307 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 692420008308 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 692420008309 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 692420008310 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 692420008311 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 692420008312 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 692420008313 active site 692420008314 octamer interface [polypeptide binding]; other site 692420008315 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 692420008316 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420008318 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420008319 substrate binding site [chemical binding]; other site 692420008320 oxyanion hole (OAH) forming residues; other site 692420008321 trimer interface [polypeptide binding]; other site 692420008322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008323 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 692420008324 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 692420008325 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 692420008326 dimer interface [polypeptide binding]; other site 692420008327 tetramer interface [polypeptide binding]; other site 692420008328 PYR/PP interface [polypeptide binding]; other site 692420008329 TPP binding site [chemical binding]; other site 692420008330 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 692420008331 TPP-binding site; other site 692420008332 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 692420008333 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420008334 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 692420008335 TspO/MBR family; Region: TspO_MBR; cl01379 692420008336 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420008337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 692420008338 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 692420008339 DinB superfamily; Region: DinB_2; pfam12867 692420008340 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420008341 MOSC domain; Region: MOSC; pfam03473 692420008342 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 692420008343 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 692420008344 active site 692420008345 NAD binding site [chemical binding]; other site 692420008346 metal binding site [ion binding]; metal-binding site 692420008347 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 692420008348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420008349 tetramerization interface [polypeptide binding]; other site 692420008350 NAD(P) binding site [chemical binding]; other site 692420008351 catalytic residues [active] 692420008352 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420008353 Helix-turn-helix domains; Region: HTH; cl00088 692420008354 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 692420008355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008356 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 692420008357 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 692420008358 SH3-like domain; Region: SH3_8; pfam13457 692420008359 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 692420008360 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 692420008361 heme-binding site [chemical binding]; other site 692420008362 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 692420008363 FAD binding pocket [chemical binding]; other site 692420008364 FAD binding motif [chemical binding]; other site 692420008365 phosphate binding motif [ion binding]; other site 692420008366 beta-alpha-beta structure motif; other site 692420008367 NAD binding pocket [chemical binding]; other site 692420008368 Heme binding pocket [chemical binding]; other site 692420008369 Cupin domain; Region: Cupin_2; cl09118 692420008370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420008371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420008372 binding surface 692420008373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420008374 TPR motif; other site 692420008375 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420008376 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 692420008377 Holin family; Region: Phage_holin_4; cl01989 692420008378 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420008379 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420008380 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 692420008381 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420008382 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420008383 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420008384 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420008385 Phage tail protein; Region: Sipho_tail; pfam05709 692420008386 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 692420008387 Phage-related minor tail protein [Function unknown]; Region: COG5280 692420008388 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 692420008389 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420008390 catalytic residue [active] 692420008391 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420008392 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 692420008393 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 692420008394 Phage capsid family; Region: Phage_capsid; pfam05065 692420008395 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420008396 Phage portal protein; Region: Phage_portal; pfam04860 692420008397 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 692420008398 Phage Terminase; Region: Terminase_1; pfam03354 692420008399 Phage terminase, small subunit; Region: Terminase_4; cl01525 692420008400 BRO family, N-terminal domain; Region: Bro-N; cl10591 692420008401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420008402 non-specific DNA binding site [nucleotide binding]; other site 692420008403 salt bridge; other site 692420008404 sequence-specific DNA binding site [nucleotide binding]; other site 692420008405 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 692420008406 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420008407 Int/Topo IB signature motif; other site 692420008408 Bacitracin resistance protein BacA; Region: BacA; cl00858 692420008409 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420008410 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420008411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420008412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008413 intracellular protease, PfpI family; Region: PfpI; TIGR01382 692420008414 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 692420008415 proposed catalytic triad [active] 692420008416 conserved cys residue [active] 692420008417 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008418 Cache domain; Region: Cache_1; pfam02743 692420008419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008420 dimerization interface [polypeptide binding]; other site 692420008421 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008422 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008423 dimer interface [polypeptide binding]; other site 692420008424 putative CheW interface [polypeptide binding]; other site 692420008425 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008426 Cache domain; Region: Cache_1; pfam02743 692420008427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008428 dimerization interface [polypeptide binding]; other site 692420008429 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 692420008430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008431 dimer interface [polypeptide binding]; other site 692420008432 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 692420008433 putative CheW interface [polypeptide binding]; other site 692420008434 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008435 Cache domain; Region: Cache_1; pfam02743 692420008436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008437 dimerization interface [polypeptide binding]; other site 692420008438 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008439 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008440 dimer interface [polypeptide binding]; other site 692420008441 putative CheW interface [polypeptide binding]; other site 692420008442 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008443 Cache domain; Region: Cache_1; pfam02743 692420008444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008445 dimerization interface [polypeptide binding]; other site 692420008446 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008448 dimer interface [polypeptide binding]; other site 692420008449 putative CheW interface [polypeptide binding]; other site 692420008450 transglutaminase; Provisional; Region: tgl; PRK03187 692420008451 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 692420008452 Nitronate monooxygenase; Region: NMO; pfam03060 692420008453 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 692420008454 FMN binding site [chemical binding]; other site 692420008455 substrate binding site [chemical binding]; other site 692420008456 putative catalytic residue [active] 692420008457 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420008458 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420008459 Ca binding site [ion binding]; other site 692420008460 active site 692420008461 catalytic site [active] 692420008462 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420008463 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420008464 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420008465 Transporter associated domain; Region: CorC_HlyC; cl08393 692420008466 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 692420008467 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 692420008468 Ion channel; Region: Ion_trans_2; cl11596 692420008469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008470 YugN-like family; Region: YugN; pfam08868 692420008471 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 692420008472 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 692420008473 active site 692420008474 dimer interface [polypeptide binding]; other site 692420008475 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 692420008476 dimer interface [polypeptide binding]; other site 692420008477 active site 692420008478 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 692420008479 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 692420008480 dimer interface [polypeptide binding]; other site 692420008481 active site 692420008482 metal binding site [ion binding]; metal-binding site 692420008483 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 692420008484 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 692420008485 dimer interface [polypeptide binding]; other site 692420008486 active site 692420008487 metal binding site [ion binding]; metal-binding site 692420008488 Domain of unknown function (DUF378); Region: DUF378; cl00943 692420008489 general stress protein 13; Validated; Region: PRK08059 692420008490 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 692420008491 RNA binding site [nucleotide binding]; other site 692420008492 hypothetical protein; Validated; Region: PRK07682 692420008493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420008494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008495 homodimer interface [polypeptide binding]; other site 692420008496 catalytic residue [active] 692420008497 Helix-turn-helix domains; Region: HTH; cl00088 692420008498 Helix-turn-helix domains; Region: HTH; cl00088 692420008499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420008500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008501 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 692420008502 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 692420008503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420008504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008505 homodimer interface [polypeptide binding]; other site 692420008506 catalytic residue [active] 692420008507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420008508 dimer interface [polypeptide binding]; other site 692420008509 phosphorylation site [posttranslational modification] 692420008510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008511 ATP binding site [chemical binding]; other site 692420008512 Mg2+ binding site [ion binding]; other site 692420008513 G-X-G motif; other site 692420008514 Kinase associated protein B; Region: KapB; pfam08810 692420008515 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 692420008516 active site 692420008517 substrate binding site [chemical binding]; other site 692420008518 catalytic site [active] 692420008519 sugar efflux transporter; Region: 2A0120; TIGR00899 692420008520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008521 putative substrate translocation pore; other site 692420008522 Transglycosylase; Region: Transgly; cl07896 692420008523 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420008524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420008525 Protein of unknown function, DUF393; Region: DUF393; cl01136 692420008526 sensory histidine kinase DcuS; Provisional; Region: PRK11086 692420008527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420008528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008529 ATP binding site [chemical binding]; other site 692420008530 Mg2+ binding site [ion binding]; other site 692420008531 G-X-G motif; other site 692420008532 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420008533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008534 active site 692420008535 phosphorylation site [posttranslational modification] 692420008536 intermolecular recognition site; other site 692420008537 dimerization interface [polypeptide binding]; other site 692420008538 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 692420008539 ligand binding site [chemical binding]; other site 692420008540 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 692420008541 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 692420008542 Walker A/P-loop; other site 692420008543 ATP binding site [chemical binding]; other site 692420008544 Q-loop/lid; other site 692420008545 ABC transporter signature motif; other site 692420008546 Walker B; other site 692420008547 D-loop; other site 692420008548 H-loop/switch region; other site 692420008549 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 692420008550 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 692420008551 TM-ABC transporter signature motif; other site 692420008552 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 692420008553 TM-ABC transporter signature motif; other site 692420008554 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 692420008555 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 692420008556 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 692420008557 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 692420008558 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 692420008559 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 692420008560 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 692420008561 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 692420008562 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 692420008563 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 692420008564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 692420008565 CoenzymeA binding site [chemical binding]; other site 692420008566 subunit interaction site [polypeptide binding]; other site 692420008567 PHB binding site; other site 692420008568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420008569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008570 active site 692420008571 phosphorylation site [posttranslational modification] 692420008572 intermolecular recognition site; other site 692420008573 dimerization interface [polypeptide binding]; other site 692420008574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420008575 DNA binding residues [nucleotide binding] 692420008576 dimerization interface [polypeptide binding]; other site 692420008577 Histidine kinase; Region: HisKA_3; pfam07730 692420008578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008579 ATP binding site [chemical binding]; other site 692420008580 Mg2+ binding site [ion binding]; other site 692420008581 G-X-G motif; other site 692420008582 Bacillus competence pheromone ComX; Region: ComX; pfam05952 692420008583 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 692420008584 aspartate-rich region 2; other site 692420008585 DegQ (SacQ) family; Region: DegQ; pfam08181 692420008586 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 692420008587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 692420008588 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 692420008589 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 692420008590 active site 692420008591 Isochorismatase family; Region: Isochorismatase; pfam00857 692420008592 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420008593 catalytic triad [active] 692420008594 conserved cis-peptide bond; other site 692420008595 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 692420008596 YueH-like protein; Region: YueH; pfam14166 692420008597 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420008598 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420008599 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 692420008600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 692420008601 short chain dehydrogenase; Provisional; Region: PRK06924 692420008602 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 692420008603 NADP binding site [chemical binding]; other site 692420008604 homodimer interface [polypeptide binding]; other site 692420008605 active site 692420008606 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 692420008607 Predicted membrane protein [Function unknown]; Region: COG1511 692420008608 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 692420008609 Predicted membrane protein [Function unknown]; Region: COG1511 692420008610 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 692420008611 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 692420008612 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 692420008613 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420008614 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420008615 Domain of unknown function DUF87; Region: DUF87; pfam01935 692420008616 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 692420008617 Ubiquitin-like proteins; Region: UBQ; cl00155 692420008618 Proteins of 100 residues with WXG; Region: WXG100; cl02005 692420008619 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420008620 CodY GAF-like domain; Region: CodY; pfam06018 692420008621 Helix-turn-helix domains; Region: HTH; cl00088 692420008622 alanine dehydrogenase; Region: alaDH; TIGR00518 692420008623 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 692420008624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008625 Uncharacterized conserved protein [Function unknown]; Region: COG5634 692420008626 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 692420008627 MbtH-like protein; Region: MbtH; cl01279 692420008628 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 692420008629 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008630 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420008631 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 692420008632 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420008633 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008634 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008635 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420008636 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 692420008637 hydrophobic substrate binding pocket; other site 692420008638 Isochorismatase family; Region: Isochorismatase; pfam00857 692420008639 active site 692420008640 conserved cis-peptide bond; other site 692420008641 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420008642 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 692420008643 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008644 AMP-binding enzyme; Region: AMP-binding; cl15778 692420008645 isochorismate synthase DhbC; Validated; Region: PRK06923 692420008646 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420008647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420008648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008649 NAD(P) binding site [chemical binding]; other site 692420008650 active site 692420008651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420008652 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 692420008653 Moco binding site; other site 692420008654 metal coordination site [ion binding]; other site 692420008655 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 692420008656 Predicted permease [General function prediction only]; Region: COG2056 692420008657 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 692420008658 multifunctional aminopeptidase A; Provisional; Region: PRK00913 692420008659 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 692420008660 interface (dimer of trimers) [polypeptide binding]; other site 692420008661 Substrate-binding/catalytic site; other site 692420008662 Zn-binding sites [ion binding]; other site 692420008663 Divergent PAP2 family; Region: DUF212; cl00855 692420008664 3D domain; Region: 3D; cl01439 692420008665 Putative membrane protein; Region: YuiB; pfam14068 692420008666 chaperone protein DnaJ; Provisional; Region: PRK14290 692420008667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420008668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420008669 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 692420008670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420008671 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 692420008672 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 692420008673 active site 692420008674 Integral membrane protein DUF95; Region: DUF95; cl00572 692420008675 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420008676 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 692420008677 Walker A/P-loop; other site 692420008678 ATP binding site [chemical binding]; other site 692420008679 Q-loop/lid; other site 692420008680 ABC transporter signature motif; other site 692420008681 Walker B; other site 692420008682 D-loop; other site 692420008683 H-loop/switch region; other site 692420008684 potential frameshift: common BLAST hit: gi|154687326|ref|YP_001422487.1| YjcK 692420008685 similar to ribosomal-protein-alanine acetyltransferase fragment; ribosomal-protein-alanine acetyltransferase;, Acyl-CoA N-acyltransferase 692420008686 similar to ribosomal-protein-alanine N-acetyltransferase fragment; 'information pathways; Protein modification' 692420008687 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 692420008688 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 692420008689 putative NAD(P) binding site [chemical binding]; other site 692420008690 active site 692420008691 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 692420008692 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 692420008693 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 692420008694 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 692420008695 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 692420008696 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420008697 Nucleoside recognition; Region: Gate; cl00486 692420008698 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420008699 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 692420008700 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420008701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420008702 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 692420008703 NifU-like domain; Region: NifU; cl00484 692420008704 potential frameshift: common BLAST hit: gi|154687335|ref|YP_001422496.1| YuxL 692420008705 similar to acylaminoacyl-peptidase fragment 692420008706 similar to acylaminoacyl-peptidase fragment; Protein tolB; flags: Precursor;, Six-bladed beta-propeller, TolB-like 692420008707 homoserine kinase; Region: thrB; TIGR00191 692420008708 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420008709 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420008710 threonine synthase; Reviewed; Region: PRK06721 692420008711 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 692420008712 homodimer interface [polypeptide binding]; other site 692420008713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008714 catalytic residue [active] 692420008715 homoserine dehydrogenase; Provisional; Region: PRK06349 692420008716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008717 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 692420008718 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 692420008719 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420008720 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 692420008721 tetramer interfaces [polypeptide binding]; other site 692420008722 binuclear metal-binding site [ion binding]; other site 692420008723 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 692420008724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420008725 active site 692420008726 motif I; other site 692420008727 motif II; other site 692420008728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420008729 Protein of unknown function DUF86; Region: DUF86; cl01031 692420008730 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 692420008731 lipoyl synthase; Provisional; Region: PRK05481 692420008732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420008733 FeS/SAM binding site; other site 692420008734 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420008735 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 692420008736 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 692420008737 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 692420008738 active site 692420008739 metal binding site [ion binding]; metal-binding site 692420008740 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420008741 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 692420008742 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 692420008743 Protein of unknown function DUF72; Region: DUF72; cl00777 692420008744 allantoinase; Provisional; Region: PRK06189 692420008745 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 692420008746 active site 692420008747 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 692420008748 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420008749 Helix-turn-helix domains; Region: HTH; cl00088 692420008750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420008752 putative substrate translocation pore; other site 692420008753 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 692420008754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420008755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420008756 catalytic residue [active] 692420008757 allantoate amidohydrolase; Reviewed; Region: PRK09290 692420008758 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 692420008759 active site 692420008760 metal binding site [ion binding]; metal-binding site 692420008761 dimer interface [polypeptide binding]; other site 692420008762 Endonuclease I; Region: Endonuclease_1; cl01003 692420008763 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 692420008764 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 692420008765 Walker A/P-loop; other site 692420008766 ATP binding site [chemical binding]; other site 692420008767 Q-loop/lid; other site 692420008768 ABC transporter signature motif; other site 692420008769 Walker B; other site 692420008770 D-loop; other site 692420008771 H-loop/switch region; other site 692420008772 TOBE domain; Region: TOBE_2; cl01440 692420008773 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 692420008774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420008775 DNA-binding site [nucleotide binding]; DNA binding site 692420008776 UTRA domain; Region: UTRA; cl01230 692420008777 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 692420008778 substrate binding site [chemical binding]; other site 692420008779 ATP binding site [chemical binding]; other site 692420008780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 692420008781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008782 dimer interface [polypeptide binding]; other site 692420008783 conserved gate region; other site 692420008784 putative PBP binding loops; other site 692420008785 ABC-ATPase subunit interface; other site 692420008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008787 dimer interface [polypeptide binding]; other site 692420008788 conserved gate region; other site 692420008789 putative PBP binding loops; other site 692420008790 ABC-ATPase subunit interface; other site 692420008791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 692420008792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420008793 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 692420008794 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 692420008795 putative active site [active] 692420008796 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 692420008797 dimer interface [polypeptide binding]; other site 692420008798 active site 692420008799 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420008800 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 692420008801 DNA binding residues [nucleotide binding] 692420008802 dimer interface [polypeptide binding]; other site 692420008803 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 692420008804 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 692420008805 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 692420008806 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 692420008807 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 692420008808 GIY-YIG motif/motif A; other site 692420008809 active site 692420008810 catalytic site [active] 692420008811 putative DNA binding site [nucleotide binding]; other site 692420008812 metal binding site [ion binding]; metal-binding site 692420008813 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 692420008814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420008815 S-adenosylmethionine binding site [chemical binding]; other site 692420008816 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 692420008817 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 692420008818 chitosan binding site [chemical binding]; other site 692420008819 catalytic residues [active] 692420008820 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420008821 substrate binding site [chemical binding]; other site 692420008822 amidase catalytic site [active] 692420008823 Zn binding residues [ion binding]; other site 692420008824 Bacterial SH3 domain; Region: SH3_3; cl02551 692420008825 Holin family; Region: Phage_holin_4; cl01989 692420008826 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420008827 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420008828 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420008829 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420008830 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 692420008831 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420008832 Phage tail protein; Region: Sipho_tail; pfam05709 692420008833 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 692420008834 Phage-related minor tail protein [Function unknown]; Region: COG5280 692420008835 Phage-related tail protein [Function unknown]; Region: COG5283 692420008836 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 692420008837 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420008838 catalytic residue [active] 692420008839 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420008840 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 692420008841 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 692420008842 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 692420008843 oligomerization interface [polypeptide binding]; other site 692420008844 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 692420008845 Phage capsid family; Region: Phage_capsid; pfam05065 692420008846 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 692420008847 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 692420008848 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420008849 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 692420008850 Phage Terminase; Region: Terminase_1; pfam03354 692420008851 Phage terminase, small subunit; Region: Terminase_4; cl01525 692420008852 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 692420008853 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420008854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420008855 ATP binding site [chemical binding]; other site 692420008856 putative Mg++ binding site [ion binding]; other site 692420008857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420008858 nucleotide binding region [chemical binding]; other site 692420008859 ATP-binding site [chemical binding]; other site 692420008860 Virulence-associated protein E; Region: VirE; pfam05272 692420008861 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 692420008862 DNA binding site [nucleotide binding] 692420008863 active site 692420008864 catalytic site [active] 692420008865 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 692420008866 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 692420008867 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 692420008868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420008869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420008870 non-specific DNA binding site [nucleotide binding]; other site 692420008871 salt bridge; other site 692420008872 sequence-specific DNA binding site [nucleotide binding]; other site 692420008873 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 692420008874 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420008875 Int/Topo IB signature motif; other site 692420008876 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 692420008877 FeS assembly protein SufB; Region: sufB; TIGR01980 692420008878 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 692420008879 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 692420008880 trimerization site [polypeptide binding]; other site 692420008881 active site 692420008882 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420008883 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 692420008884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420008885 catalytic residue [active] 692420008886 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 692420008887 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 692420008888 FeS assembly ATPase SufC; Region: sufC; TIGR01978 692420008889 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 692420008890 Walker A/P-loop; other site 692420008891 ATP binding site [chemical binding]; other site 692420008892 Q-loop/lid; other site 692420008893 ABC transporter signature motif; other site 692420008894 Walker B; other site 692420008895 D-loop; other site 692420008896 H-loop/switch region; other site 692420008897 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 692420008898 NMT1-like family; Region: NMT1_2; cl15260 692420008899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008900 dimer interface [polypeptide binding]; other site 692420008901 conserved gate region; other site 692420008902 ABC-ATPase subunit interface; other site 692420008903 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 692420008904 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 692420008905 Walker A/P-loop; other site 692420008906 ATP binding site [chemical binding]; other site 692420008907 Q-loop/lid; other site 692420008908 ABC transporter signature motif; other site 692420008909 Walker B; other site 692420008910 D-loop; other site 692420008911 H-loop/switch region; other site 692420008912 NIL domain; Region: NIL; cl09633 692420008913 SCP-2 sterol transfer family; Region: SCP2; cl01225 692420008914 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420008915 catalytic residues [active] 692420008916 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 692420008917 active site 692420008918 metal binding site [ion binding]; metal-binding site 692420008919 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 692420008920 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 692420008921 lipoyl attachment site [posttranslational modification]; other site 692420008922 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 692420008923 ArsC family; Region: ArsC; pfam03960 692420008924 putative ArsC-like catalytic residues; other site 692420008925 putative TRX-like catalytic residues [active] 692420008926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 692420008927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420008928 active site 692420008929 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 692420008930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420008931 dimer interface [polypeptide binding]; other site 692420008932 active site 692420008933 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 692420008934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008935 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420008936 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420008937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420008938 substrate binding site [chemical binding]; other site 692420008939 oxyanion hole (OAH) forming residues; other site 692420008940 trimer interface [polypeptide binding]; other site 692420008941 YuzL-like protein; Region: YuzL; pfam14115 692420008942 Proline dehydrogenase; Region: Pro_dh; cl03282 692420008943 Pyruvate formate lyase; Region: PFL; pfam02901 692420008944 Coat F domain; Region: Coat_F; cl15836 692420008945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420008946 Helix-turn-helix domains; Region: HTH; cl00088 692420008947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420008949 putative substrate translocation pore; other site 692420008950 Restriction endonuclease BamHI; Region: BamHI; pfam02923 692420008951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420008952 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 692420008953 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420008954 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420008955 Walker A/P-loop; other site 692420008956 ATP binding site [chemical binding]; other site 692420008957 Q-loop/lid; other site 692420008958 ABC transporter signature motif; other site 692420008959 Walker B; other site 692420008960 D-loop; other site 692420008961 H-loop/switch region; other site 692420008962 YusW-like protein; Region: YusW; pfam14039 692420008963 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 692420008964 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 692420008965 active site 692420008966 Zn binding site [ion binding]; other site 692420008967 short chain dehydrogenase; Provisional; Region: PRK06914 692420008968 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 692420008969 NADP binding site [chemical binding]; other site 692420008970 active site 692420008971 steroid binding site; other site 692420008972 Ferritin-like domain; Region: Ferritin; pfam00210 692420008973 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 692420008974 dimerization interface [polypeptide binding]; other site 692420008975 DPS ferroxidase diiron center [ion binding]; other site 692420008976 ion pore; other site 692420008977 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 692420008978 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420008979 protein binding site [polypeptide binding]; other site 692420008980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420008981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008982 active site 692420008983 phosphorylation site [posttranslational modification] 692420008984 intermolecular recognition site; other site 692420008985 dimerization interface [polypeptide binding]; other site 692420008986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420008987 DNA binding site [nucleotide binding] 692420008988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420008989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008990 dimerization interface [polypeptide binding]; other site 692420008991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420008992 dimer interface [polypeptide binding]; other site 692420008993 phosphorylation site [posttranslational modification] 692420008994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008995 ATP binding site [chemical binding]; other site 692420008996 Mg2+ binding site [ion binding]; other site 692420008997 G-X-G motif; other site 692420008998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420008999 Helix-turn-helix domains; Region: HTH; cl00088 692420009000 fumarate hydratase; Reviewed; Region: fumC; PRK00485 692420009001 Class II fumarases; Region: Fumarase_classII; cd01362 692420009002 active site 692420009003 tetramer interface [polypeptide binding]; other site 692420009004 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 692420009005 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420009006 Spore germination protein; Region: Spore_permease; cl15802 692420009007 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 692420009008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009010 active site 692420009011 phosphorylation site [posttranslational modification] 692420009012 intermolecular recognition site; other site 692420009013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009014 DNA binding residues [nucleotide binding] 692420009015 dimerization interface [polypeptide binding]; other site 692420009016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420009017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420009018 dimerization interface [polypeptide binding]; other site 692420009019 Histidine kinase; Region: HisKA_3; pfam07730 692420009020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009021 ATP binding site [chemical binding]; other site 692420009022 Mg2+ binding site [ion binding]; other site 692420009023 G-X-G motif; other site 692420009024 Predicted membrane protein [Function unknown]; Region: COG4758 692420009025 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 692420009026 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 692420009027 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 692420009028 PspA/IM30 family; Region: PspA_IM30; pfam04012 692420009029 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 692420009030 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 692420009031 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 692420009032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009033 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420009034 putative substrate translocation pore; other site 692420009035 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 692420009036 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420009037 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420009038 Walker A/P-loop; other site 692420009039 ATP binding site [chemical binding]; other site 692420009040 Q-loop/lid; other site 692420009041 ABC transporter signature motif; other site 692420009042 Walker B; other site 692420009043 D-loop; other site 692420009044 H-loop/switch region; other site 692420009045 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 692420009046 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009048 ABC-ATPase subunit interface; other site 692420009049 dimer interface [polypeptide binding]; other site 692420009050 putative PBP binding regions; other site 692420009051 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420009052 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 692420009053 putative binding site residues; other site 692420009054 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420009055 classical (c) SDRs; Region: SDR_c; cd05233 692420009056 NAD(P) binding site [chemical binding]; other site 692420009057 active site 692420009058 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 692420009059 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 692420009060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009061 dimer interface [polypeptide binding]; other site 692420009062 phosphorylation site [posttranslational modification] 692420009063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009064 ATP binding site [chemical binding]; other site 692420009065 Mg2+ binding site [ion binding]; other site 692420009066 G-X-G motif; other site 692420009067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009069 active site 692420009070 phosphorylation site [posttranslational modification] 692420009071 intermolecular recognition site; other site 692420009072 dimerization interface [polypeptide binding]; other site 692420009073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009074 DNA binding site [nucleotide binding] 692420009075 hypothetical protein; Provisional; Region: PRK14082 692420009076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 692420009077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420009078 DNA binding residues [nucleotide binding] 692420009079 YvrJ protein family; Region: YvrJ; pfam12841 692420009080 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 692420009081 Cupin domain; Region: Cupin_2; cl09118 692420009082 Cupin domain; Region: Cupin_2; cl09118 692420009083 Regulatory protein YrvL; Region: YrvL; pfam14184 692420009084 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420009085 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420009086 Walker A/P-loop; other site 692420009087 ATP binding site [chemical binding]; other site 692420009088 Q-loop/lid; other site 692420009089 ABC transporter signature motif; other site 692420009090 Walker B; other site 692420009091 D-loop; other site 692420009092 H-loop/switch region; other site 692420009093 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009095 ABC-ATPase subunit interface; other site 692420009096 dimer interface [polypeptide binding]; other site 692420009097 putative PBP binding regions; other site 692420009098 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009100 ABC-ATPase subunit interface; other site 692420009101 dimer interface [polypeptide binding]; other site 692420009102 putative PBP binding regions; other site 692420009103 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420009104 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420009105 putative ligand binding residues [chemical binding]; other site 692420009106 Leucine carboxyl methyltransferase; Region: LCM; cl01306 692420009107 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 692420009108 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 692420009109 potential frameshift: common BLAST hit: gi|154687449|ref|YP_001422610.1| YvgJ 692420009110 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420009111 Sulfatase; Region: Sulfatase; cl10460 692420009112 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420009113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420009114 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 692420009115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 692420009116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009117 dimer interface [polypeptide binding]; other site 692420009118 conserved gate region; other site 692420009119 putative PBP binding loops; other site 692420009120 ABC-ATPase subunit interface; other site 692420009121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009123 active site 692420009124 phosphorylation site [posttranslational modification] 692420009125 intermolecular recognition site; other site 692420009126 dimerization interface [polypeptide binding]; other site 692420009127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009128 DNA binding residues [nucleotide binding] 692420009129 dimerization interface [polypeptide binding]; other site 692420009130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420009131 Histidine kinase; Region: HisKA_3; pfam07730 692420009132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420009133 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420009134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009135 Walker A/P-loop; other site 692420009136 ATP binding site [chemical binding]; other site 692420009137 Q-loop/lid; other site 692420009138 ABC transporter signature motif; other site 692420009139 Walker B; other site 692420009140 D-loop; other site 692420009141 H-loop/switch region; other site 692420009142 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420009143 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420009144 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420009145 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420009146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420009147 active site 692420009148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420009149 catalytic tetrad [active] 692420009150 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 692420009151 chromosome segregation protein; Provisional; Region: PRK03918 692420009152 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 692420009153 sulfite reductase subunit beta; Provisional; Region: PRK13504 692420009154 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420009155 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420009156 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 692420009157 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420009158 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 692420009159 FAD binding pocket [chemical binding]; other site 692420009160 FAD binding motif [chemical binding]; other site 692420009161 catalytic residues [active] 692420009162 NAD binding pocket [chemical binding]; other site 692420009163 phosphate binding motif [ion binding]; other site 692420009164 beta-alpha-beta structure motif; other site 692420009165 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 692420009166 Family description; Region: UvrD_C_2; cl15862 692420009167 Predicted membrane protein [Function unknown]; Region: COG2860 692420009168 UPF0126 domain; Region: UPF0126; pfam03458 692420009169 UPF0126 domain; Region: UPF0126; pfam03458 692420009170 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 692420009171 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 692420009172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 692420009173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009175 metal-binding site [ion binding] 692420009176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420009177 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420009178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009179 metal-binding site [ion binding] 692420009180 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009182 metal-binding site [ion binding] 692420009183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420009184 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420009185 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009186 metal-binding site [ion binding] 692420009187 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 692420009188 putative homotetramer interface [polypeptide binding]; other site 692420009189 putative homodimer interface [polypeptide binding]; other site 692420009190 putative allosteric switch controlling residues; other site 692420009191 putative metal binding site [ion binding]; other site 692420009192 putative homodimer-homodimer interface [polypeptide binding]; other site 692420009193 putative oxidoreductase; Provisional; Region: PRK11579 692420009194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009195 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 692420009196 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420009197 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 692420009198 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 692420009199 active site 692420009200 non-prolyl cis peptide bond; other site 692420009201 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 692420009202 catalytic residues [active] 692420009203 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 692420009204 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420009205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420009206 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 692420009207 Walker A/P-loop; other site 692420009208 ATP binding site [chemical binding]; other site 692420009209 Q-loop/lid; other site 692420009210 ABC transporter signature motif; other site 692420009211 Walker B; other site 692420009212 D-loop; other site 692420009213 H-loop/switch region; other site 692420009214 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420009215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009216 dimer interface [polypeptide binding]; other site 692420009217 conserved gate region; other site 692420009218 putative PBP binding loops; other site 692420009219 ABC-ATPase subunit interface; other site 692420009220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009221 dimer interface [polypeptide binding]; other site 692420009222 conserved gate region; other site 692420009223 putative PBP binding loops; other site 692420009224 ABC-ATPase subunit interface; other site 692420009225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420009226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420009227 substrate binding pocket [chemical binding]; other site 692420009228 membrane-bound complex binding site; other site 692420009229 hinge residues; other site 692420009230 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 692420009231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420009232 substrate binding pocket [chemical binding]; other site 692420009233 membrane-bound complex binding site; other site 692420009234 hinge residues; other site 692420009235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420009236 Coenzyme A binding pocket [chemical binding]; other site 692420009237 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420009238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420009239 Helix-turn-helix domains; Region: HTH; cl00088 692420009240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420009241 dimerization interface [polypeptide binding]; other site 692420009242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420009243 classical (c) SDRs; Region: SDR_c; cd05233 692420009244 NAD(P) binding site [chemical binding]; other site 692420009245 active site 692420009246 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 692420009247 RNAase interaction site [polypeptide binding]; other site 692420009248 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 692420009249 SmpB-tmRNA interface; other site 692420009250 ribonuclease R; Region: RNase_R; TIGR02063 692420009251 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 692420009252 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 692420009253 RNB domain; Region: RNB; pfam00773 692420009254 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 692420009255 RNA binding site [nucleotide binding]; other site 692420009256 Esterase/lipase [General function prediction only]; Region: COG1647 692420009257 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420009258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420009259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009260 salt bridge; other site 692420009261 non-specific DNA binding site [nucleotide binding]; other site 692420009262 sequence-specific DNA binding site [nucleotide binding]; other site 692420009263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420009264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009265 non-specific DNA binding site [nucleotide binding]; other site 692420009266 salt bridge; other site 692420009267 sequence-specific DNA binding site [nucleotide binding]; other site 692420009268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009269 non-specific DNA binding site [nucleotide binding]; other site 692420009270 salt bridge; other site 692420009271 sequence-specific DNA binding site [nucleotide binding]; other site 692420009272 Helix-turn-helix domains; Region: HTH; cl00088 692420009273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009274 dimer interface [polypeptide binding]; other site 692420009275 phosphorylation site [posttranslational modification] 692420009276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009277 ATP binding site [chemical binding]; other site 692420009278 Mg2+ binding site [ion binding]; other site 692420009279 G-X-G motif; other site 692420009280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009282 active site 692420009283 phosphorylation site [posttranslational modification] 692420009284 intermolecular recognition site; other site 692420009285 dimerization interface [polypeptide binding]; other site 692420009286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009287 DNA binding site [nucleotide binding] 692420009288 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420009289 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420009290 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 692420009291 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 692420009292 Walker A/P-loop; other site 692420009293 ATP binding site [chemical binding]; other site 692420009294 Q-loop/lid; other site 692420009295 ABC transporter signature motif; other site 692420009296 Walker B; other site 692420009297 D-loop; other site 692420009298 H-loop/switch region; other site 692420009299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009300 dimer interface [polypeptide binding]; other site 692420009301 conserved gate region; other site 692420009302 putative PBP binding loops; other site 692420009303 ABC-ATPase subunit interface; other site 692420009304 NMT1-like family; Region: NMT1_2; cl15260 692420009305 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420009306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009307 dimer interface [polypeptide binding]; other site 692420009308 conserved gate region; other site 692420009309 putative PBP binding loops; other site 692420009310 ABC-ATPase subunit interface; other site 692420009311 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 692420009312 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 692420009313 Walker A/P-loop; other site 692420009314 ATP binding site [chemical binding]; other site 692420009315 Q-loop/lid; other site 692420009316 ABC transporter signature motif; other site 692420009317 Walker B; other site 692420009318 D-loop; other site 692420009319 H-loop/switch region; other site 692420009320 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 692420009321 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420009322 Helix-turn-helix domains; Region: HTH; cl00088 692420009323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009324 dimer interface [polypeptide binding]; other site 692420009325 conserved gate region; other site 692420009326 putative PBP binding loops; other site 692420009327 ABC-ATPase subunit interface; other site 692420009328 NMT1-like family; Region: NMT1_2; cl15260 692420009329 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420009330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009331 dimer interface [polypeptide binding]; other site 692420009332 conserved gate region; other site 692420009333 putative PBP binding loops; other site 692420009334 ABC-ATPase subunit interface; other site 692420009335 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 692420009336 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 692420009337 Walker A/P-loop; other site 692420009338 ATP binding site [chemical binding]; other site 692420009339 Q-loop/lid; other site 692420009340 ABC transporter signature motif; other site 692420009341 Walker B; other site 692420009342 D-loop; other site 692420009343 H-loop/switch region; other site 692420009344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 692420009345 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420009346 Helix-turn-helix domains; Region: HTH; cl00088 692420009347 MarC family integral membrane protein; Region: MarC; cl00919 692420009348 Predicted membrane protein [Function unknown]; Region: COG4640 692420009349 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 692420009350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420009351 Coenzyme A binding pocket [chemical binding]; other site 692420009352 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420009353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009354 putative substrate translocation pore; other site 692420009355 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 692420009356 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 692420009357 WbqC-like protein family; Region: WbqC; pfam08889 692420009358 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420009359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420009360 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 692420009361 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420009362 catalytic residue [active] 692420009363 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 692420009364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009365 NAD(P) binding site [chemical binding]; other site 692420009366 active site 692420009367 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 692420009368 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420009369 inhibitor-cofactor binding pocket; inhibition site 692420009370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009371 catalytic residue [active] 692420009372 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 692420009373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009374 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420009375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009376 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 692420009377 PA/protease domain interface [polypeptide binding]; other site 692420009378 putative integrin binding motif; other site 692420009379 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 692420009380 metal binding site [ion binding]; metal-binding site 692420009381 enolase; Provisional; Region: eno; PRK00077 692420009382 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 692420009383 dimer interface [polypeptide binding]; other site 692420009384 metal binding site [ion binding]; metal-binding site 692420009385 substrate binding pocket [chemical binding]; other site 692420009386 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 692420009387 Sulfatase; Region: Sulfatase; cl10460 692420009388 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 692420009389 substrate binding site [chemical binding]; other site 692420009390 dimer interface [polypeptide binding]; other site 692420009391 catalytic triad [active] 692420009392 Phosphoglycerate kinase; Region: PGK; pfam00162 692420009393 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 692420009394 substrate binding site [chemical binding]; other site 692420009395 hinge regions; other site 692420009396 ADP binding site [chemical binding]; other site 692420009397 catalytic site [active] 692420009398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009399 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 692420009400 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 692420009401 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 692420009402 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 692420009403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009404 putative substrate translocation pore; other site 692420009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009407 DNA-binding site [nucleotide binding]; DNA binding site 692420009408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420009409 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 692420009410 putative dimerization interface [polypeptide binding]; other site 692420009411 putative ligand binding site [chemical binding]; other site 692420009412 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420009413 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 692420009414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420009415 Helix-turn-helix domains; Region: HTH; cl00088 692420009416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420009417 dimerization interface [polypeptide binding]; other site 692420009418 EamA-like transporter family; Region: EamA; cl01037 692420009419 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 692420009420 EamA-like transporter family; Region: EamA; cl01037 692420009421 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420009422 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420009423 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420009424 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420009425 putative active site [active] 692420009426 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 692420009427 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 692420009428 N- and C-terminal domain interface [polypeptide binding]; other site 692420009429 putative active site [active] 692420009430 catalytic site [active] 692420009431 metal binding site [ion binding]; metal-binding site 692420009432 carbohydrate binding site [chemical binding]; other site 692420009433 ATP binding site [chemical binding]; other site 692420009434 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 692420009435 GntP family permease; Region: GntP_permease; pfam02447 692420009436 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 692420009437 iron-sulfur cluster-binding protein; Region: TIGR00273 692420009438 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 692420009439 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 692420009440 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 692420009441 Cysteine-rich domain; Region: CCG; pfam02754 692420009442 Cysteine-rich domain; Region: CCG; pfam02754 692420009443 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 692420009444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420009445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009446 homodimer interface [polypeptide binding]; other site 692420009447 catalytic residue [active] 692420009448 Transcriptional regulators [Transcription]; Region: FadR; COG2186 692420009449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009450 DNA-binding site [nucleotide binding]; DNA binding site 692420009451 FCD domain; Region: FCD; cl11656 692420009452 glycolate transporter; Provisional; Region: PRK09695 692420009453 L-lactate permease; Region: Lactate_perm; cl00701 692420009454 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 692420009455 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 692420009456 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 692420009457 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 692420009458 YvfG protein; Region: YvfG; pfam09628 692420009459 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 692420009460 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 692420009461 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420009462 inhibitor-cofactor binding pocket; inhibition site 692420009463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009464 catalytic residue [active] 692420009465 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 692420009466 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 692420009467 putative trimer interface [polypeptide binding]; other site 692420009468 putative CoA binding site [chemical binding]; other site 692420009469 Bacterial sugar transferase; Region: Bac_transf; cl00939 692420009470 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 692420009471 MatE; Region: MatE; cl10513 692420009472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420009473 active site 692420009474 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 692420009475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420009476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420009477 active site 692420009478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420009479 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 692420009480 putative ADP-binding pocket [chemical binding]; other site 692420009481 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420009482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 692420009483 active site 692420009484 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 692420009485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420009486 putative ADP-binding pocket [chemical binding]; other site 692420009487 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 692420009488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009489 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 692420009490 NAD(P) binding site [chemical binding]; other site 692420009491 homodimer interface [polypeptide binding]; other site 692420009492 substrate binding site [chemical binding]; other site 692420009493 active site 692420009494 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 692420009495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009496 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 692420009497 Chain length determinant protein; Region: Wzz; cl15801 692420009498 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420009499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009500 non-specific DNA binding site [nucleotide binding]; other site 692420009501 salt bridge; other site 692420009502 sequence-specific DNA binding site [nucleotide binding]; other site 692420009503 Anti-repressor SinI; Region: SinI; pfam08671 692420009504 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 692420009505 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 692420009506 substrate binding pocket [chemical binding]; other site 692420009507 catalytic triad [active] 692420009508 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 692420009509 folate binding site [chemical binding]; other site 692420009510 NADP+ binding site [chemical binding]; other site 692420009511 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 692420009512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420009515 Predicted membrane protein [Function unknown]; Region: COG2364 692420009516 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420009517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420009518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420009519 Coenzyme A binding pocket [chemical binding]; other site 692420009520 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 692420009521 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 692420009522 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420009523 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420009524 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420009525 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 692420009526 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 692420009527 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420009528 substrate binding [chemical binding]; other site 692420009529 active site 692420009530 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420009531 galactoside permease; Reviewed; Region: lacY; PRK09528 692420009532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009533 putative substrate translocation pore; other site 692420009534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420009535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420009536 DNA binding site [nucleotide binding] 692420009537 domain linker motif; other site 692420009538 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 692420009539 dimerization interface [polypeptide binding]; other site 692420009540 ligand binding site [chemical binding]; other site 692420009541 sodium binding site [ion binding]; other site 692420009542 Clp protease; Region: CLP_protease; pfam00574 692420009543 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 692420009544 oligomer interface [polypeptide binding]; other site 692420009545 active site residues [active] 692420009546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420009547 Helix-turn-helix domains; Region: HTH; cl00088 692420009548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420009549 dimerization interface [polypeptide binding]; other site 692420009550 PrpF protein; Region: PrpF; pfam04303 692420009551 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 692420009552 benzoate transport; Region: 2A0115; TIGR00895 692420009553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009554 putative substrate translocation pore; other site 692420009555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009556 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 692420009557 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 692420009558 putative transporter; Provisional; Region: PRK11660 692420009559 Sulfate transporter family; Region: Sulfate_transp; cl15842 692420009560 Sulfate transporter family; Region: Sulfate_transp; cl15842 692420009561 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 692420009562 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 692420009563 active site clefts [active] 692420009564 zinc binding site [ion binding]; other site 692420009565 dimer interface [polypeptide binding]; other site 692420009566 glyoxylate reductase; Reviewed; Region: PRK13243 692420009567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009568 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 692420009569 active site 692420009570 N-acetyltransferase; Region: Acetyltransf_2; cl00949 692420009571 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 692420009572 dimerization domain swap beta strand [polypeptide binding]; other site 692420009573 regulatory protein interface [polypeptide binding]; other site 692420009574 active site 692420009575 regulatory phosphorylation site [posttranslational modification]; other site 692420009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 692420009577 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 692420009578 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 692420009579 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 692420009580 phosphate binding site [ion binding]; other site 692420009581 putative substrate binding pocket [chemical binding]; other site 692420009582 dimer interface [polypeptide binding]; other site 692420009583 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 692420009584 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 692420009585 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 692420009586 putative active site [active] 692420009587 nucleotide binding site [chemical binding]; other site 692420009588 nudix motif; other site 692420009589 putative metal binding site [ion binding]; other site 692420009590 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 692420009591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420009593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 692420009594 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 692420009595 NlpC/P60 family; Region: NLPC_P60; cl11438 692420009596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420009597 binding surface 692420009598 TPR motif; other site 692420009599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420009600 TPR motif; other site 692420009601 binding surface 692420009602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009603 dimer interface [polypeptide binding]; other site 692420009604 phosphorylation site [posttranslational modification] 692420009605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009606 ATP binding site [chemical binding]; other site 692420009607 Mg2+ binding site [ion binding]; other site 692420009608 G-X-G motif; other site 692420009609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009611 active site 692420009612 phosphorylation site [posttranslational modification] 692420009613 intermolecular recognition site; other site 692420009614 dimerization interface [polypeptide binding]; other site 692420009615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009616 DNA binding site [nucleotide binding] 692420009617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420009618 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420009619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009620 Walker A/P-loop; other site 692420009621 ATP binding site [chemical binding]; other site 692420009622 Q-loop/lid; other site 692420009623 ABC transporter signature motif; other site 692420009624 Walker B; other site 692420009625 D-loop; other site 692420009626 H-loop/switch region; other site 692420009627 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 692420009628 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 692420009629 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 692420009630 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 692420009631 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 692420009632 substrate binding site [chemical binding]; other site 692420009633 glutamase interaction surface [polypeptide binding]; other site 692420009634 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 692420009635 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 692420009636 catalytic residues [active] 692420009637 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 692420009638 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 692420009639 putative active site [active] 692420009640 oxyanion strand; other site 692420009641 catalytic triad [active] 692420009642 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 692420009643 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 692420009644 putative active site pocket [active] 692420009645 4-fold oligomerization interface [polypeptide binding]; other site 692420009646 metal binding residues [ion binding]; metal-binding site 692420009647 3-fold/trimer interface [polypeptide binding]; other site 692420009648 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 692420009649 histidinol dehydrogenase; Region: hisD; TIGR00069 692420009650 NAD binding site [chemical binding]; other site 692420009651 dimerization interface [polypeptide binding]; other site 692420009652 product binding site; other site 692420009653 substrate binding site [chemical binding]; other site 692420009654 zinc binding site [ion binding]; other site 692420009655 catalytic residues [active] 692420009656 ATP phosphoribosyltransferase; Region: HisG; cl15266 692420009657 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 692420009658 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 692420009659 dimer interface [polypeptide binding]; other site 692420009660 motif 1; other site 692420009661 active site 692420009662 motif 2; other site 692420009663 motif 3; other site 692420009664 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 692420009665 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 692420009666 putative active site [active] 692420009667 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 692420009668 trimer interface [polypeptide binding]; other site 692420009669 active site 692420009670 substrate binding site [chemical binding]; other site 692420009671 CoA binding site [chemical binding]; other site 692420009672 pyrophosphatase PpaX; Provisional; Region: PRK13288 692420009673 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420009674 motif I; other site 692420009675 active site 692420009676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420009677 motif II; other site 692420009678 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 692420009679 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 692420009680 DRTGG domain; Region: DRTGG; cl12147 692420009681 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 692420009682 Hpr binding site; other site 692420009683 active site 692420009684 homohexamer subunit interaction site [polypeptide binding]; other site 692420009685 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 692420009686 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 692420009687 active site 692420009688 dimer interface [polypeptide binding]; other site 692420009689 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 692420009690 active site 692420009691 trimer interface [polypeptide binding]; other site 692420009692 allosteric site; other site 692420009693 active site lid [active] 692420009694 hexamer (dimer of trimers) interface [polypeptide binding]; other site 692420009695 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420009696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009697 DNA-binding site [nucleotide binding]; DNA binding site 692420009698 UTRA domain; Region: UTRA; cl01230 692420009699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420009700 Helix-turn-helix domains; Region: HTH; cl00088 692420009701 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 692420009702 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 692420009703 putative active site [active] 692420009704 putative metal binding site [ion binding]; other site 692420009705 Membrane protein of unknown function; Region: DUF360; cl00850 692420009706 PspC domain; Region: PspC; cl00864 692420009707 Uncharacterized conserved protein [Function unknown]; Region: COG3595 692420009708 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 692420009709 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 692420009710 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 692420009711 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 692420009712 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 692420009713 excinuclease ABC subunit B; Provisional; Region: PRK05298 692420009714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420009715 ATP binding site [chemical binding]; other site 692420009716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420009717 nucleotide binding region [chemical binding]; other site 692420009718 ATP-binding site [chemical binding]; other site 692420009719 Ultra-violet resistance protein B; Region: UvrB; pfam12344 692420009720 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 692420009721 phosphoenolpyruvate synthase; Validated; Region: PRK06241 692420009722 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 692420009723 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 692420009724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420009725 Helix-turn-helix domains; Region: HTH; cl00088 692420009726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009727 putative substrate translocation pore; other site 692420009728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420009729 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 692420009730 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420009731 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420009732 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420009733 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420009734 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 692420009735 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420009736 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 692420009737 C-terminal peptidase (prc); Region: prc; TIGR00225 692420009738 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 692420009739 protein binding site [polypeptide binding]; other site 692420009740 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 692420009741 Catalytic dyad [active] 692420009742 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 692420009743 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 692420009744 Right handed beta helix region; Region: Beta_helix; pfam13229 692420009745 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 692420009746 FtsX-like permease family; Region: FtsX; cl15850 692420009747 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 692420009748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009749 Walker A/P-loop; other site 692420009750 ATP binding site [chemical binding]; other site 692420009751 Q-loop/lid; other site 692420009752 ABC transporter signature motif; other site 692420009753 Walker B; other site 692420009754 D-loop; other site 692420009755 H-loop/switch region; other site 692420009756 Cytochrome c; Region: Cytochrom_C; cl11414 692420009757 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420009758 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420009759 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420009760 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420009761 peptide chain release factor 2; Provisional; Region: PRK06746 692420009762 RF-1 domain; Region: RF-1; cl02875 692420009763 RF-1 domain; Region: RF-1; cl02875 692420009764 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 692420009765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009766 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 692420009767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009768 SEC-C motif; Region: SEC-C; pfam02810 692420009769 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 692420009770 30S subunit binding site; other site 692420009771 Flagellar protein FliT; Region: FliT; cl05125 692420009772 Flagellar protein FliS; Region: FliS; cl00654 692420009773 flagellar capping protein; Validated; Region: fliD; PRK07737 692420009774 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 692420009775 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 692420009776 flagellin; Provisional; Region: PRK12804 692420009777 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 692420009778 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 692420009779 Global regulator protein family; Region: CsrA; cl00670 692420009780 FliW protein; Region: FliW; cl00740 692420009781 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 692420009782 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 692420009783 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 692420009784 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 692420009785 FlgN protein; Region: FlgN; cl09176 692420009786 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 692420009787 flagellar operon protein TIGR03826; Region: YvyF 692420009788 comF family protein; Region: comF; TIGR00201 692420009789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420009790 active site 692420009791 Late competence development protein ComFB; Region: ComFB; pfam10719 692420009792 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 692420009793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420009794 ATP binding site [chemical binding]; other site 692420009795 putative Mg++ binding site [ion binding]; other site 692420009796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420009797 nucleotide binding region [chemical binding]; other site 692420009798 ATP-binding site [chemical binding]; other site 692420009799 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 692420009800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009802 active site 692420009803 phosphorylation site [posttranslational modification] 692420009804 intermolecular recognition site; other site 692420009805 dimerization interface [polypeptide binding]; other site 692420009806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009807 DNA binding residues [nucleotide binding] 692420009808 dimerization interface [polypeptide binding]; other site 692420009809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420009810 Histidine kinase; Region: HisKA_3; pfam07730 692420009811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009812 ATP binding site [chemical binding]; other site 692420009813 Mg2+ binding site [ion binding]; other site 692420009814 G-X-G motif; other site 692420009815 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 692420009816 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 692420009817 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 692420009818 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 692420009819 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 692420009820 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 692420009821 Mg++ binding site [ion binding]; other site 692420009822 putative catalytic motif [active] 692420009823 substrate binding site [chemical binding]; other site 692420009824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 692420009825 putative homodimer interface [polypeptide binding]; other site 692420009826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420009827 active site 692420009828 Chain length determinant protein; Region: Wzz; cl15801 692420009829 O-Antigen ligase; Region: Wzy_C; cl04850 692420009830 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 692420009831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009832 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420009833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009834 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 692420009835 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 692420009836 colanic acid exporter; Provisional; Region: PRK10459 692420009837 MatE; Region: MatE; cl10513 692420009838 Bacterial sugar transferase; Region: Bac_transf; cl00939 692420009839 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 692420009840 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009841 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009842 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009843 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420009844 active site 692420009845 metal binding site [ion binding]; metal-binding site 692420009846 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009847 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 692420009848 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009849 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420009850 Stage II sporulation protein; Region: SpoIID; pfam08486 692420009851 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 692420009852 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 692420009853 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 692420009854 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 692420009855 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 692420009856 active site 692420009857 homodimer interface [polypeptide binding]; other site 692420009858 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 692420009859 active site 692420009860 tetramer interface; other site 692420009861 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 692420009862 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 692420009863 Walker A/P-loop; other site 692420009864 ATP binding site [chemical binding]; other site 692420009865 Q-loop/lid; other site 692420009866 ABC transporter signature motif; other site 692420009867 Walker B; other site 692420009868 D-loop; other site 692420009869 H-loop/switch region; other site 692420009870 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420009871 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 692420009872 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 692420009873 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 692420009874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420009875 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 692420009876 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 692420009877 active site 692420009878 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 692420009879 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 692420009880 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 692420009881 Bacterial SH3 domain; Region: SH3_3; cl02551 692420009882 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 692420009883 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420009884 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 692420009885 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420009886 Spore germination protein; Region: Spore_permease; cl15802 692420009887 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 692420009888 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 692420009889 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 692420009890 Probable Catalytic site; other site 692420009891 metal-binding site 692420009892 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 692420009893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420009894 S-adenosylmethionine binding site [chemical binding]; other site 692420009895 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420009896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009897 putative substrate translocation pore; other site 692420009898 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 692420009899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420009900 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420009901 active site 692420009902 motif I; other site 692420009903 motif II; other site 692420009904 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 692420009905 Protein of unknown function (DUF904); Region: DUF904; cl11531 692420009906 NlpC/P60 family; Region: NLPC_P60; cl11438 692420009907 NlpC/P60 family; Region: NLPC_P60; cl11438 692420009908 NlpC/P60 family; Region: NLPC_P60; cl11438 692420009909 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 692420009910 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 692420009911 putative active site [active] 692420009912 putative metal binding site [ion binding]; other site 692420009913 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 692420009914 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 692420009915 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420009916 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420009917 Spore germination protein; Region: Spore_permease; cl15802 692420009918 potential frameshift: common BLAST hit: gi|154687707|ref|YP_001422868.1| GerKC1 692420009919 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 692420009920 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 692420009921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420009922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420009923 DNA binding site [nucleotide binding] 692420009924 domain linker motif; other site 692420009925 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420009926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420009927 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 692420009928 substrate binding site [chemical binding]; other site 692420009929 dimer interface [polypeptide binding]; other site 692420009930 ATP binding site [chemical binding]; other site 692420009931 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 692420009932 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 692420009933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420009934 Walker A/P-loop; other site 692420009935 ATP binding site [chemical binding]; other site 692420009936 Q-loop/lid; other site 692420009937 ABC transporter signature motif; other site 692420009938 Walker B; other site 692420009939 D-loop; other site 692420009940 H-loop/switch region; other site 692420009941 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 692420009942 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 692420009943 TM-ABC transporter signature motif; other site 692420009944 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 692420009945 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 692420009946 ligand binding site [chemical binding]; other site 692420009947 dimerization interface [polypeptide binding]; other site 692420009948 Bacterial SH3 domain; Region: SH3_3; cl02551 692420009949 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 692420009950 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 692420009951 acetolactate synthase; Reviewed; Region: PRK08617 692420009952 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420009953 PYR/PP interface [polypeptide binding]; other site 692420009954 dimer interface [polypeptide binding]; other site 692420009955 TPP binding site [chemical binding]; other site 692420009956 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 692420009957 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 692420009958 TPP-binding site [chemical binding]; other site 692420009959 dimer interface [polypeptide binding]; other site 692420009960 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 692420009961 Helix-turn-helix domains; Region: HTH; cl00088 692420009962 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 692420009963 putative dimerization interface [polypeptide binding]; other site 692420009964 putative substrate binding pocket [chemical binding]; other site 692420009965 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 692420009966 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 692420009967 transmembrane helices; other site 692420009968 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 692420009969 Flavin Reductases; Region: FlaRed; cl00801 692420009970 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 692420009971 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 692420009972 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 692420009973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 692420009974 Helix-turn-helix domains; Region: HTH; cl00088 692420009975 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 692420009976 Chromate transporter; Region: Chromate_transp; pfam02417 692420009977 Chromate transporter; Region: Chromate_transp; pfam02417 692420009978 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 692420009979 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 692420009980 Uncharacterized conserved protein [Function unknown]; Region: COG5444 692420009981 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 692420009982 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 692420009983 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 692420009984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009985 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420009986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009987 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 692420009988 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 692420009989 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 692420009990 Nucleotide binding site [chemical binding]; other site 692420009991 Chain length determinant protein; Region: Wzz; cl15801 692420009992 SWIM zinc finger; Region: SWIM; cl15408 692420009993 SNF2 Helicase protein; Region: DUF3670; pfam12419 692420009994 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420009995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420009996 ATP binding site [chemical binding]; other site 692420009997 putative Mg++ binding site [ion binding]; other site 692420009998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420009999 nucleotide binding region [chemical binding]; other site 692420010000 ATP-binding site [chemical binding]; other site 692420010001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010002 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420010003 active site 692420010004 motif I; other site 692420010005 motif II; other site 692420010006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010007 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420010008 Helix-turn-helix domains; Region: HTH; cl00088 692420010009 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420010010 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 692420010011 dimer interface [polypeptide binding]; other site 692420010012 ssDNA binding site [nucleotide binding]; other site 692420010013 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420010014 YwpF-like protein; Region: YwpF; pfam14183 692420010015 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 692420010016 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 692420010017 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 692420010018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420010019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420010020 binding surface 692420010021 TPR motif; other site 692420010022 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 692420010023 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420010024 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 692420010025 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 692420010026 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 692420010027 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 692420010028 rod shape-determining protein Mbl; Provisional; Region: PRK13928 692420010029 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 692420010030 ATP binding site [chemical binding]; other site 692420010031 profilin binding site; other site 692420010032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 692420010033 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420010034 Helix-turn-helix domains; Region: HTH; cl00088 692420010035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010036 putative substrate translocation pore; other site 692420010037 Sodium:solute symporter family; Region: SSF; cl00456 692420010038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420010040 putative substrate translocation pore; other site 692420010041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010042 Isochorismatase family; Region: Isochorismatase; pfam00857 692420010043 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420010044 catalytic triad [active] 692420010045 conserved cis-peptide bond; other site 692420010046 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 692420010047 Nitrogen regulatory protein P-II; Region: P-II; cl00412 692420010048 Nitrogen regulatory protein P-II; Region: P-II; smart00938 692420010049 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 692420010050 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 692420010051 active site 692420010052 VanZ like family; Region: VanZ; cl01971 692420010053 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420010054 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 692420010055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420010056 Coenzyme A binding pocket [chemical binding]; other site 692420010057 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420010058 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420010059 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010060 putative active site [active] 692420010061 catalytic site [active] 692420010062 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010063 putative active site [active] 692420010064 catalytic site [active] 692420010065 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 692420010066 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420010067 NAD binding site [chemical binding]; other site 692420010068 substrate binding site [chemical binding]; other site 692420010069 putative active site [active] 692420010070 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420010071 Helix-turn-helix domains; Region: HTH; cl00088 692420010072 urease subunit alpha; Reviewed; Region: ureC; PRK13207 692420010073 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 692420010074 subunit interactions [polypeptide binding]; other site 692420010075 active site 692420010076 flap region; other site 692420010077 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 692420010078 gamma-beta subunit interface [polypeptide binding]; other site 692420010079 alpha-beta subunit interface [polypeptide binding]; other site 692420010080 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 692420010081 alpha-gamma subunit interface [polypeptide binding]; other site 692420010082 beta-gamma subunit interface [polypeptide binding]; other site 692420010083 CsbD-like; Region: CsbD; cl15799 692420010084 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 692420010085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420010086 FeS/SAM binding site; other site 692420010087 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 692420010088 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 692420010089 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 692420010090 metal ion-dependent adhesion site (MIDAS); other site 692420010091 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 692420010092 metal ion-dependent adhesion site (MIDAS); other site 692420010093 stage II sporulation protein D; Region: spore_II_D; TIGR02870 692420010094 Stage II sporulation protein; Region: SpoIID; pfam08486 692420010095 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 692420010096 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 692420010097 hinge; other site 692420010098 active site 692420010099 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 692420010100 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 692420010101 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 692420010102 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 692420010103 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 692420010104 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 692420010105 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 692420010106 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 692420010107 alpha subunit interaction interface [polypeptide binding]; other site 692420010108 Walker A motif; other site 692420010109 ATP binding site [chemical binding]; other site 692420010110 Walker B motif; other site 692420010111 inhibitor binding site; inhibition site 692420010112 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 692420010113 ATP synthase; Region: ATP-synt; cl00365 692420010114 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 692420010115 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 692420010116 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 692420010117 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 692420010118 beta subunit interaction interface [polypeptide binding]; other site 692420010119 Walker A motif; other site 692420010120 ATP binding site [chemical binding]; other site 692420010121 Walker B motif; other site 692420010122 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 692420010123 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 692420010124 Plant ATP synthase F0; Region: YMF19; cl07975 692420010125 Plant ATP synthase F0; Region: YMF19; cl07975 692420010126 ATP synthase subunit C; Region: ATP-synt_C; cl00466 692420010127 ATP synthase A chain; Region: ATP-synt_A; cl00413 692420010128 ATP synthase I chain; Region: ATP_synt_I; cl09170 692420010129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420010130 active site 692420010131 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 692420010132 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 692420010133 dimer interface [polypeptide binding]; other site 692420010134 glycine-pyridoxal phosphate binding site [chemical binding]; other site 692420010135 active site 692420010136 folate binding site [chemical binding]; other site 692420010137 Protein of unknown function (DUF436); Region: DUF436; cl01860 692420010138 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 692420010139 Low molecular weight phosphatase family; Region: LMWPc; cd00115 692420010140 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 692420010141 active site 692420010142 Domain of unknown function DUF; Region: DUF204; pfam02659 692420010143 Domain of unknown function DUF; Region: DUF204; pfam02659 692420010144 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 692420010145 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 692420010146 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420010147 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 692420010148 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 692420010149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420010150 S-adenosylmethionine binding site [chemical binding]; other site 692420010151 peptide chain release factor 1; Validated; Region: prfA; PRK00591 692420010152 RF-1 domain; Region: RF-1; cl02875 692420010153 RF-1 domain; Region: RF-1; cl02875 692420010154 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 692420010155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420010156 putative metal binding site [ion binding]; other site 692420010157 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 692420010158 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 692420010159 DNA binding residues [nucleotide binding] 692420010160 Trypanosomal VSG domain; Region: VSG_B; cl11958 692420010161 Membrane transport protein; Region: Mem_trans; cl09117 692420010162 malate dehydrogenase; Provisional; Region: PRK13529 692420010163 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420010164 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 692420010165 NAD(P) binding site [chemical binding]; other site 692420010166 thymidine kinase; Provisional; Region: PRK04296 692420010167 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 692420010168 transcription termination factor Rho; Provisional; Region: rho; PRK09376 692420010169 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 692420010170 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 692420010171 RNA binding site [nucleotide binding]; other site 692420010172 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 692420010173 multimer interface [polypeptide binding]; other site 692420010174 Walker A motif; other site 692420010175 ATP binding site [chemical binding]; other site 692420010176 Walker B motif; other site 692420010177 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 692420010178 putative active site [active] 692420010179 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 692420010180 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 692420010181 hinge; other site 692420010182 active site 692420010183 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 692420010184 active site 692420010185 intersubunit interactions; other site 692420010186 catalytic residue [active] 692420010187 hypothetical protein; Provisional; Region: PRK08185 692420010188 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 692420010189 intersubunit interface [polypeptide binding]; other site 692420010190 active site 692420010191 zinc binding site [ion binding]; other site 692420010192 Na+ binding site [ion binding]; other site 692420010193 Response regulator receiver domain; Region: Response_reg; pfam00072 692420010194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010195 active site 692420010196 phosphorylation site [posttranslational modification] 692420010197 intermolecular recognition site; other site 692420010198 dimerization interface [polypeptide binding]; other site 692420010199 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 692420010200 CTP synthetase; Validated; Region: pyrG; PRK05380 692420010201 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 692420010202 Catalytic site [active] 692420010203 active site 692420010204 UTP binding site [chemical binding]; other site 692420010205 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 692420010206 active site 692420010207 putative oxyanion hole; other site 692420010208 catalytic triad [active] 692420010209 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 692420010210 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 692420010211 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 692420010212 Cysteine-rich domain; Region: CCG; pfam02754 692420010213 Cysteine-rich domain; Region: CCG; pfam02754 692420010214 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010215 putative active site [active] 692420010216 catalytic site [active] 692420010217 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010218 PLD-like domain; Region: PLDc_2; pfam13091 692420010219 putative active site [active] 692420010220 catalytic site [active] 692420010221 UV-endonuclease UvdE; Region: UvdE; cl10036 692420010222 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420010223 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420010224 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 692420010225 Walker A/P-loop; other site 692420010226 ATP binding site [chemical binding]; other site 692420010227 Q-loop/lid; other site 692420010228 ABC transporter signature motif; other site 692420010229 Walker B; other site 692420010230 D-loop; other site 692420010231 H-loop/switch region; other site 692420010232 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420010233 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420010234 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010235 putative active site [active] 692420010236 catalytic site [active] 692420010237 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010238 putative active site [active] 692420010239 catalytic site [active] 692420010240 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 692420010241 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 692420010242 nitrate reductase, beta subunit; Region: narH; TIGR01660 692420010243 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 692420010244 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 692420010245 [4Fe-4S] binding site [ion binding]; other site 692420010246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010247 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010248 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010249 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 692420010250 molybdopterin cofactor binding site; other site 692420010251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 692420010252 ligand binding site [chemical binding]; other site 692420010253 flexible hinge region; other site 692420010254 YwiC-like protein; Region: YwiC; pfam14256 692420010255 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 692420010256 ligand binding site [chemical binding]; other site 692420010257 flexible hinge region; other site 692420010258 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 692420010259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010260 putative substrate translocation pore; other site 692420010261 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 692420010262 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 692420010263 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 692420010264 active site 692420010265 HIGH motif; other site 692420010266 KMSK motif region; other site 692420010267 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 692420010268 tRNA binding surface [nucleotide binding]; other site 692420010269 anticodon binding site; other site 692420010270 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 692420010271 potential frameshift: common BLAST hit: gi|154687850|ref|YP_001423011.1| YwhL 692420010272 Uncharacterized conserved protein [Function unknown]; Region: COG3391 692420010273 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010274 Uncharacterized conserved protein [Function unknown]; Region: COG3391 692420010275 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010276 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010277 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 692420010278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420010279 binding surface 692420010280 TPR motif; other site 692420010281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420010282 Arginase family; Region: Arginase; cl00306 692420010283 spermidine synthase; Provisional; Region: PRK00811 692420010284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420010285 Transglycosylase; Region: Transgly; cl07896 692420010286 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420010287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 692420010288 YwhD family; Region: YwhD; pfam08741 692420010289 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 692420010290 active site 692420010291 putative substrate binding region [chemical binding]; other site 692420010292 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 692420010293 active site 1 [active] 692420010294 dimer interface [polypeptide binding]; other site 692420010295 hexamer interface [polypeptide binding]; other site 692420010296 active site 2 [active] 692420010297 Helix-turn-helix domains; Region: HTH; cl00088 692420010298 Helix-turn-helix domains; Region: HTH; cl00088 692420010299 amino acid transporter; Region: 2A0306; TIGR00909 692420010300 Spore germination protein; Region: Spore_permease; cl15802 692420010301 Spore germination protein; Region: Spore_permease; cl15802 692420010302 Uncharacterized conserved protein [Function unknown]; Region: COG3465 692420010303 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 692420010304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420010305 Zn2+ binding site [ion binding]; other site 692420010306 Mg2+ binding site [ion binding]; other site 692420010307 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 692420010308 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 692420010309 Helix-turn-helix domains; Region: HTH; cl00088 692420010310 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 692420010311 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420010312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420010313 Walker A/P-loop; other site 692420010314 ATP binding site [chemical binding]; other site 692420010315 Q-loop/lid; other site 692420010316 ABC transporter signature motif; other site 692420010317 Walker B; other site 692420010318 D-loop; other site 692420010319 H-loop/switch region; other site 692420010320 ABC-2 type transporter; Region: ABC2_membrane; cl11417 692420010321 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 692420010322 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 692420010323 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 692420010324 Helix-turn-helix domains; Region: HTH; cl00088 692420010325 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 692420010326 putative dimerization interface [polypeptide binding]; other site 692420010327 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 692420010328 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 692420010329 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 692420010330 Chlorite dismutase; Region: Chlor_dismutase; cl01280 692420010331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420010332 non-specific DNA binding site [nucleotide binding]; other site 692420010333 salt bridge; other site 692420010334 sequence-specific DNA binding site [nucleotide binding]; other site 692420010335 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420010336 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 692420010337 putative NAD(P) binding site [chemical binding]; other site 692420010338 putative active site [active] 692420010339 transaminase; Reviewed; Region: PRK08068 692420010340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420010341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420010342 homodimer interface [polypeptide binding]; other site 692420010343 catalytic residue [active] 692420010344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010345 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420010346 putative substrate translocation pore; other site 692420010347 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 692420010348 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420010349 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420010350 classical (c) SDRs; Region: SDR_c; cd05233 692420010351 NAD(P) binding site [chemical binding]; other site 692420010352 active site 692420010353 Cupin domain; Region: Cupin_2; cl09118 692420010354 Cupin domain; Region: Cupin_2; cl09118 692420010355 Prephenate dehydratase; Region: PDT; pfam00800 692420010356 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420010357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010358 putative substrate translocation pore; other site 692420010359 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 692420010360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010361 putative substrate translocation pore; other site 692420010362 S-methylmethionine transporter; Provisional; Region: PRK11387 692420010363 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 692420010364 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 692420010365 putative metal binding site [ion binding]; other site 692420010366 putative dimer interface [polypeptide binding]; other site 692420010367 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 692420010368 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 692420010369 Glutamate binding site [chemical binding]; other site 692420010370 homodimer interface [polypeptide binding]; other site 692420010371 NAD binding site [chemical binding]; other site 692420010372 catalytic residues [active] 692420010373 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420010374 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420010375 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 692420010376 NAD(P) binding site [chemical binding]; other site 692420010377 Cupin domain; Region: Cupin_2; cl09118 692420010378 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 692420010379 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 692420010380 NADP binding site [chemical binding]; other site 692420010381 active site 692420010382 putative substrate binding site [chemical binding]; other site 692420010383 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 692420010384 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 692420010385 NAD binding site [chemical binding]; other site 692420010386 substrate binding site [chemical binding]; other site 692420010387 homodimer interface [polypeptide binding]; other site 692420010388 active site 692420010389 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 692420010390 substrate binding site; other site 692420010391 tetramer interface; other site 692420010392 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 692420010393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420010394 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 692420010395 ligand binding site; other site 692420010396 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 692420010397 NeuB family; Region: NeuB; cl00496 692420010398 SAF domain; Region: SAF; cl00555 692420010399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420010400 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 692420010401 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 692420010402 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420010403 inhibitor-cofactor binding pocket; inhibition site 692420010404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420010405 catalytic residue [active] 692420010406 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 692420010407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420010408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420010409 active site 692420010410 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 692420010411 Protein of unknown function (DUF423); Region: DUF423; cl01008 692420010412 Permease family; Region: Xan_ur_permease; pfam00860 692420010413 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 692420010414 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 692420010415 ligand binding site [chemical binding]; other site 692420010416 active site 692420010417 UGI interface [polypeptide binding]; other site 692420010418 catalytic site [active] 692420010419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420010420 active site 692420010421 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 692420010422 dimer interface [polypeptide binding]; other site 692420010423 substrate binding site [chemical binding]; other site 692420010424 ATP binding site [chemical binding]; other site 692420010425 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 692420010426 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420010427 substrate binding [chemical binding]; other site 692420010428 active site 692420010429 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420010430 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 692420010431 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420010432 active site turn [active] 692420010433 phosphorylation site [posttranslational modification] 692420010434 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420010435 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420010436 CAT RNA binding domain; Region: CAT_RBD; cl03904 692420010437 PRD domain; Region: PRD; cl15445 692420010438 PRD domain; Region: PRD; cl15445 692420010439 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 692420010440 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420010441 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 692420010442 putative active site [active] 692420010443 catalytic triad [active] 692420010444 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 692420010445 PA/protease domain interface [polypeptide binding]; other site 692420010446 putative integrin binding motif; other site 692420010447 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 692420010448 FlgD Ig-like domain; Region: FlgD_ig; cl15790 692420010449 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 692420010450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420010451 Predicted transcriptional regulator [Transcription]; Region: COG2378 692420010452 Helix-turn-helix domains; Region: HTH; cl00088 692420010453 WYL domain; Region: WYL; cl14852 692420010454 short chain dehydrogenase; Provisional; Region: PRK06523 692420010455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420010456 NAD(P) binding site [chemical binding]; other site 692420010457 active site 692420010458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 692420010459 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 692420010460 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 692420010461 dimer interface [polypeptide binding]; other site 692420010462 FMN binding site [chemical binding]; other site 692420010463 NADPH bind site [chemical binding]; other site 692420010464 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 692420010465 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420010466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420010467 Coenzyme A binding pocket [chemical binding]; other site 692420010468 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 692420010469 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 692420010470 Subunit I/III interface [polypeptide binding]; other site 692420010471 Subunit III/IV interface [polypeptide binding]; other site 692420010472 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 692420010473 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 692420010474 D-pathway; other site 692420010475 Putative ubiquinol binding site [chemical binding]; other site 692420010476 Low-spin heme (heme b) binding site [chemical binding]; other site 692420010477 Putative water exit pathway; other site 692420010478 Binuclear center (heme o3/CuB) [ion binding]; other site 692420010479 K-pathway; other site 692420010480 Putative proton exit pathway; other site 692420010481 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 692420010482 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 692420010483 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 692420010484 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 692420010485 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 692420010486 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 692420010487 galactokinase; Provisional; Region: PRK05322 692420010488 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 692420010489 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420010490 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420010491 GtrA-like protein; Region: GtrA; cl00971 692420010492 Helix-turn-helix domains; Region: HTH; cl00088 692420010493 Uso1 / p115 like vesicle tethering protein, head region; Region: Uso1_p115_head; pfam04869 692420010494 Anti-repressor SinI; Region: SinI; pfam08671 692420010495 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 692420010496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420010497 S-adenosylmethionine binding site [chemical binding]; other site 692420010498 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 692420010499 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 692420010500 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 692420010501 catalytic residues [active] 692420010502 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 692420010503 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 692420010504 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 692420010505 Imelysin; Region: Peptidase_M75; cl09159 692420010506 Iron permease FTR1 family; Region: FTR1; cl00475 692420010507 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 692420010508 thiamine phosphate binding site [chemical binding]; other site 692420010509 active site 692420010510 pyrophosphate binding site [ion binding]; other site 692420010511 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 692420010512 substrate binding site [chemical binding]; other site 692420010513 multimerization interface [polypeptide binding]; other site 692420010514 ATP binding site [chemical binding]; other site 692420010515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420010516 Helix-turn-helix domains; Region: HTH; cl00088 692420010517 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 692420010518 putative dimerization interface [polypeptide binding]; other site 692420010519 LrgA family; Region: LrgA; cl00608 692420010520 LrgB-like family; Region: LrgB; cl00596 692420010521 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 692420010522 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 692420010523 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420010524 DNA binding residues [nucleotide binding] 692420010525 dimer interface [polypeptide binding]; other site 692420010526 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 692420010527 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 692420010528 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 692420010529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420010530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420010531 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 692420010532 active site 692420010533 metal binding site [ion binding]; metal-binding site 692420010534 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420010535 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420010536 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420010537 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420010538 active site 692420010539 catalytic residues [active] 692420010540 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 692420010541 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 692420010542 Ligand binding site; other site 692420010543 metal-binding site 692420010544 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420010545 synthetase active site [active] 692420010546 NTP binding site [chemical binding]; other site 692420010547 metal binding site [ion binding]; metal-binding site 692420010548 UbiA prenyltransferase family; Region: UbiA; cl00337 692420010549 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 692420010550 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 692420010551 AMP-binding enzyme; Region: AMP-binding; cl15778 692420010552 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 692420010553 Phosphopantetheine attachment site; Region: PP-binding; cl09936 692420010554 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 692420010555 DltD N-terminal region; Region: DltD_N; pfam04915 692420010556 DltD central region; Region: DltD_M; pfam04918 692420010557 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 692420010558 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 692420010559 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 692420010560 homodimer interface [polypeptide binding]; other site 692420010561 substrate-cofactor binding pocket; other site 692420010562 catalytic residue [active] 692420010563 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 692420010564 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 692420010565 NAD binding site [chemical binding]; other site 692420010566 sugar binding site [chemical binding]; other site 692420010567 divalent metal binding site [ion binding]; other site 692420010568 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420010569 dimer interface [polypeptide binding]; other site 692420010570 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420010571 methionine cluster; other site 692420010572 active site 692420010573 phosphorylation site [posttranslational modification] 692420010574 metal binding site [ion binding]; metal-binding site 692420010575 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420010576 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420010577 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 692420010578 active site 692420010579 P-loop; other site 692420010580 phosphorylation site [posttranslational modification] 692420010581 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420010582 Helix-turn-helix domains; Region: HTH; cl00088 692420010583 Helix-turn-helix domains; Region: HTH; cl00088 692420010584 PRD domain; Region: PRD; cl15445 692420010585 PRD domain; Region: PRD; cl15445 692420010586 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420010587 P-loop; other site 692420010588 active site 692420010589 phosphorylation site [posttranslational modification] 692420010590 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420010591 active site 692420010592 phosphorylation site [posttranslational modification] 692420010593 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 692420010594 active site 692420010595 DNA binding site [nucleotide binding] 692420010596 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420010597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420010598 ABC-ATPase subunit interface; other site 692420010599 dimer interface [polypeptide binding]; other site 692420010600 putative PBP binding regions; other site 692420010601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420010602 ABC-ATPase subunit interface; other site 692420010603 dimer interface [polypeptide binding]; other site 692420010604 putative PBP binding regions; other site 692420010605 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420010606 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 692420010607 intersubunit interface [polypeptide binding]; other site 692420010608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420010609 dimerization interface [polypeptide binding]; other site 692420010610 putative DNA binding site [nucleotide binding]; other site 692420010611 putative Zn2+ binding site [ion binding]; other site 692420010612 arsenical pump membrane protein; Provisional; Region: PRK15445 692420010613 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 692420010614 transmembrane helices; other site 692420010615 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 692420010616 active site 692420010617 P-loop; other site 692420010618 phosphorylation site [posttranslational modification] 692420010619 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420010620 active site 692420010621 methionine cluster; other site 692420010622 phosphorylation site [posttranslational modification] 692420010623 metal binding site [ion binding]; metal-binding site 692420010624 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420010625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420010626 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420010627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 692420010628 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 692420010629 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 692420010630 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420010631 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 692420010632 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 692420010633 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 692420010634 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 692420010635 tetramer interface [polypeptide binding]; other site 692420010636 heme binding pocket [chemical binding]; other site 692420010637 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 692420010638 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 692420010639 active site 692420010640 Sodium:solute symporter family; Region: SSF; cl00456 692420010641 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 692420010642 putative ATP binding site [chemical binding]; other site 692420010643 putative substrate binding site [chemical binding]; other site 692420010644 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 692420010645 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420010646 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 692420010647 Walker A/P-loop; other site 692420010648 ATP binding site [chemical binding]; other site 692420010649 Q-loop/lid; other site 692420010650 ABC transporter signature motif; other site 692420010651 Walker B; other site 692420010652 D-loop; other site 692420010653 H-loop/switch region; other site 692420010654 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 692420010655 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 692420010656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420010657 ATP binding site [chemical binding]; other site 692420010658 Q-loop/lid; other site 692420010659 ABC transporter signature motif; other site 692420010660 Walker B; other site 692420010661 D-loop; other site 692420010662 H-loop/switch region; other site 692420010663 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 692420010664 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 692420010665 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 692420010666 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 692420010667 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 692420010668 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 692420010669 putative active site [active] 692420010670 putative metal binding site [ion binding]; other site 692420010671 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 692420010672 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 692420010673 Walker A/P-loop; other site 692420010674 ATP binding site [chemical binding]; other site 692420010675 Q-loop/lid; other site 692420010676 ABC transporter signature motif; other site 692420010677 Walker B; other site 692420010678 D-loop; other site 692420010679 H-loop/switch region; other site 692420010680 TOBE domain; Region: TOBE_2; cl01440 692420010681 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420010682 Helix-turn-helix domains; Region: HTH; cl00088 692420010683 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420010684 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420010685 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420010686 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 692420010687 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 692420010688 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 692420010689 UDP-glucose 4-epimerase; Region: PLN02240 692420010690 NAD binding site [chemical binding]; other site 692420010691 homodimer interface [polypeptide binding]; other site 692420010692 active site 692420010693 substrate binding site [chemical binding]; other site 692420010694 peptidase T; Region: peptidase-T; TIGR01882 692420010695 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 692420010696 metal binding site [ion binding]; metal-binding site 692420010697 dimer interface [polypeptide binding]; other site 692420010698 Scramblase; Region: Scramblase; cl02043 692420010699 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 692420010700 substrate binding site [chemical binding]; other site 692420010701 THF binding site; other site 692420010702 zinc-binding site [ion binding]; other site 692420010703 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 692420010704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420010705 S-adenosylmethionine binding site [chemical binding]; other site 692420010706 nucleoside transporter; Region: nupC; TIGR00804 692420010707 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420010708 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420010709 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 692420010710 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 692420010711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420010712 Q-loop/lid; other site 692420010713 ABC transporter signature motif; other site 692420010714 Walker B; other site 692420010715 H-loop/switch region; other site 692420010716 hydroperoxidase II; Provisional; Region: katE; PRK11249 692420010717 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 692420010718 tetramer interface [polypeptide binding]; other site 692420010719 heme binding pocket [chemical binding]; other site 692420010720 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 692420010721 domain interactions; other site 692420010722 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 692420010723 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 692420010724 active site 692420010725 active site 692420010726 catalytic residues [active] 692420010727 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420010728 CAT RNA binding domain; Region: CAT_RBD; cl03904 692420010729 PRD domain; Region: PRD; cl15445 692420010730 PRD domain; Region: PRD; cl15445 692420010731 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 692420010732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010733 putative substrate translocation pore; other site 692420010734 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 692420010735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420010736 ATP binding site [chemical binding]; other site 692420010737 Mg++ binding site [ion binding]; other site 692420010738 motif III; other site 692420010739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420010740 nucleotide binding region [chemical binding]; other site 692420010741 DbpA RNA binding domain; Region: DbpA; pfam03880 692420010742 YxiJ-like protein; Region: YxiJ; pfam14176 692420010743 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 692420010744 Pectate lyase; Region: Pec_lyase_C; cl01593 692420010745 EamA-like transporter family; Region: EamA; cl01037 692420010746 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 692420010747 EamA-like transporter family; Region: EamA; cl01037 692420010748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 692420010749 Ligand Binding Site [chemical binding]; other site 692420010750 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420010751 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 692420010752 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420010753 active site turn [active] 692420010754 phosphorylation site [posttranslational modification] 692420010755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 692420010756 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 692420010757 HPr interaction site; other site 692420010758 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420010759 active site 692420010760 phosphorylation site [posttranslational modification] 692420010761 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 692420010762 additional DNA contacts [nucleotide binding]; other site 692420010763 mismatch recognition site; other site 692420010764 active site 692420010765 zinc binding site [ion binding]; other site 692420010766 DNA intercalation site [nucleotide binding]; other site 692420010767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420010768 cofactor binding site; other site 692420010769 DNA binding site [nucleotide binding] 692420010770 substrate interaction site [chemical binding]; other site 692420010771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420010772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 692420010773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420010774 Z1 domain; Region: Z1; pfam10593 692420010775 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 692420010776 AIPR protein; Region: AIPR; pfam10592 692420010777 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 692420010778 substrate binding site [chemical binding]; other site 692420010779 active site 692420010780 HutP; Region: HutP; cl07944 692420010781 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 692420010782 active sites [active] 692420010783 tetramer interface [polypeptide binding]; other site 692420010784 urocanate hydratase; Provisional; Region: PRK05414 692420010785 imidazolonepropionase; Validated; Region: PRK09356 692420010786 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 692420010787 active site 692420010788 Arginase family; Region: Arginase; cl00306 692420010789 S-methylmethionine transporter; Provisional; Region: PRK11387 692420010790 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 692420010791 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 692420010792 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 692420010793 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 692420010794 nucleoside transporter; Region: nupC; TIGR00804 692420010795 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420010796 Nucleoside recognition; Region: Gate; cl00486 692420010797 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420010798 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 692420010799 intersubunit interface [polypeptide binding]; other site 692420010800 active site 692420010801 catalytic residue [active] 692420010802 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 692420010803 Helix-turn-helix domains; Region: HTH; cl00088 692420010804 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 692420010805 sugar phosphate phosphatase; Provisional; Region: PRK10513 692420010806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010807 active site 692420010808 motif I; other site 692420010809 motif II; other site 692420010810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010811 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 692420010812 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420010813 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420010814 putative ligand binding residues [chemical binding]; other site 692420010815 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 692420010816 FtsX-like permease family; Region: FtsX; cl15850 692420010817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420010818 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 692420010819 Walker A/P-loop; other site 692420010820 ATP binding site [chemical binding]; other site 692420010821 Q-loop/lid; other site 692420010822 ABC transporter signature motif; other site 692420010823 Walker B; other site 692420010824 D-loop; other site 692420010825 H-loop/switch region; other site 692420010826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 692420010827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420010828 ATP binding site [chemical binding]; other site 692420010829 Mg2+ binding site [ion binding]; other site 692420010830 G-X-G motif; other site 692420010831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420010832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010833 active site 692420010834 phosphorylation site [posttranslational modification] 692420010835 intermolecular recognition site; other site 692420010836 dimerization interface [polypeptide binding]; other site 692420010837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420010838 DNA binding site [nucleotide binding] 692420010839 hypothetical protein; Provisional; Region: PRK08185 692420010840 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 692420010841 intersubunit interface [polypeptide binding]; other site 692420010842 active site 692420010843 zinc binding site [ion binding]; other site 692420010844 Na+ binding site [ion binding]; other site 692420010845 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420010846 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 692420010847 Metal-binding active site; metal-binding site 692420010848 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420010849 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 692420010850 DNA interaction; other site 692420010851 Metal-binding active site; metal-binding site 692420010852 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420010853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420010854 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 692420010855 Glucuronate isomerase; Region: UxaC; cl00829 692420010856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010858 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420010859 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 692420010860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420010861 PYR/PP interface [polypeptide binding]; other site 692420010862 dimer interface [polypeptide binding]; other site 692420010863 TPP binding site [chemical binding]; other site 692420010864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 692420010865 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 692420010866 TPP-binding site; other site 692420010867 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420010868 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 692420010869 substrate binding site [chemical binding]; other site 692420010870 ATP binding site [chemical binding]; other site 692420010871 KduI/IolB family; Region: KduI; cl01508 692420010872 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 692420010873 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420010874 tetrameric interface [polypeptide binding]; other site 692420010875 NAD binding site [chemical binding]; other site 692420010876 catalytic residues [active] 692420010877 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420010878 Helix-turn-helix domains; Region: HTH; cl00088 692420010879 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 692420010880 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 692420010881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420010882 active site 692420010883 catalytic tetrad [active] 692420010884 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420010885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010886 putative substrate translocation pore; other site 692420010887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010888 heat shock protein 90; Provisional; Region: PRK05218 692420010889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420010890 ATP binding site [chemical binding]; other site 692420010891 Mg2+ binding site [ion binding]; other site 692420010892 G-X-G motif; other site 692420010893 short chain dehydrogenase; Validated; Region: PRK08589 692420010894 classical (c) SDRs; Region: SDR_c; cd05233 692420010895 NAD(P) binding site [chemical binding]; other site 692420010896 active site 692420010897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420010898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010899 active site 692420010900 phosphorylation site [posttranslational modification] 692420010901 intermolecular recognition site; other site 692420010902 dimerization interface [polypeptide binding]; other site 692420010903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420010904 DNA binding residues [nucleotide binding] 692420010905 dimerization interface [polypeptide binding]; other site 692420010906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420010907 Histidine kinase; Region: HisKA_3; pfam07730 692420010908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420010909 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 692420010910 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 692420010911 putative di-iron ligands [ion binding]; other site 692420010912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420010913 Helix-turn-helix domains; Region: HTH; cl00088 692420010914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420010915 Helix-turn-helix domains; Region: HTH; cl00088 692420010916 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420010917 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 692420010918 NAD(P) binding site [chemical binding]; other site 692420010919 catalytic residues [active] 692420010920 FOG: WD40-like repeat [Function unknown]; Region: COG1520 692420010921 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 692420010922 Trp docking motif [polypeptide binding]; other site 692420010923 active site 692420010924 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 692420010925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420010926 putative DNA binding site [nucleotide binding]; other site 692420010927 dimerization interface [polypeptide binding]; other site 692420010928 putative Zn2+ binding site [ion binding]; other site 692420010929 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420010930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010931 putative substrate translocation pore; other site 692420010932 RDD family; Region: RDD; cl00746 692420010933 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420010934 metal binding site [ion binding]; metal-binding site 692420010935 peroxiredoxin; Region: AhpC; TIGR03137 692420010936 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 692420010937 dimer interface [polypeptide binding]; other site 692420010938 decamer (pentamer of dimers) interface [polypeptide binding]; other site 692420010939 catalytic triad [active] 692420010940 peroxidatic and resolving cysteines [active] 692420010941 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 692420010942 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 692420010943 catalytic residue [active] 692420010944 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 692420010945 catalytic residues [active] 692420010946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420010947 Major royal jelly protein; Region: MRJP; pfam03022 692420010948 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 692420010949 Helix-turn-helix domains; Region: HTH; cl00088 692420010950 WYL domain; Region: WYL; cl14852 692420010951 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420010952 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420010953 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 692420010954 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420010955 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420010956 catalytic residues [active] 692420010957 catalytic nucleophile [active] 692420010958 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420010959 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420010960 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420010961 Synaptic Site I dimer interface [polypeptide binding]; other site 692420010962 DNA binding site [nucleotide binding] 692420010963 Helix-turn-helix domains; Region: HTH; cl00088 692420010964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420010965 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420010966 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420010967 SpoVA protein; Region: SpoVA; cl04298 692420010968 stage V sporulation protein AD; Provisional; Region: PRK12404 692420010969 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420010970 SpoVA protein; Region: SpoVA; cl04298 692420010971 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420010972 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420010973 Protein of unknown function (DUF421); Region: DUF421; cl00990 692420010974 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420010975 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420010976 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010977 putative active site [active] 692420010978 catalytic site [active] 692420010979 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010980 putative active site [active] 692420010981 catalytic site [active] 692420010982 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 692420010983 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 692420010984 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 692420010985 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 692420010986 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 692420010987 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 692420010988 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 692420010989 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 692420010990 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 692420010991 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 692420010992 Ligand binding site; other site 692420010993 metal-binding site 692420010994 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 692420010995 XdhC Rossmann domain; Region: XdhC_C; pfam13478 692420010996 Predicted membrane protein [Function unknown]; Region: COG4129 692420010997 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 692420010998 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 692420010999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420011000 Uncharacterized conserved protein [Function unknown]; Region: COG4938 692420011001 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 692420011002 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 692420011003 putative active site [active] 692420011004 putative metal-binding site [ion binding]; other site 692420011005 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 692420011006 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 692420011007 YyzF-like protein; Region: YyzF; cl15733 692420011008 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 692420011009 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 692420011010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420011011 active site 692420011012 catalytic tetrad [active] 692420011013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420011014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011015 Coenzyme A binding pocket [chemical binding]; other site 692420011016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420011017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420011018 Arginase family; Region: Arginase; cl00306 692420011019 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 692420011020 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 692420011021 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420011022 inhibitor-cofactor binding pocket; inhibition site 692420011023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420011024 catalytic residue [active] 692420011025 Predicted integral membrane protein [Function unknown]; Region: COG5658 692420011026 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 692420011027 SdpI/YhfL protein family; Region: SdpI; pfam13630 692420011028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420011029 dimerization interface [polypeptide binding]; other site 692420011030 putative DNA binding site [nucleotide binding]; other site 692420011031 putative Zn2+ binding site [ion binding]; other site 692420011032 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 692420011033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420011034 Walker A motif; other site 692420011035 ATP binding site [chemical binding]; other site 692420011036 Walker B motif; other site 692420011037 arginine finger; other site 692420011038 Helix-turn-helix domains; Region: HTH; cl00088 692420011039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011040 putative substrate translocation pore; other site 692420011041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420011042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420011043 dimerization interface [polypeptide binding]; other site 692420011044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420011045 dimer interface [polypeptide binding]; other site 692420011046 phosphorylation site [posttranslational modification] 692420011047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011048 ATP binding site [chemical binding]; other site 692420011049 Mg2+ binding site [ion binding]; other site 692420011050 G-X-G motif; other site 692420011051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420011052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011053 active site 692420011054 phosphorylation site [posttranslational modification] 692420011055 intermolecular recognition site; other site 692420011056 dimerization interface [polypeptide binding]; other site 692420011057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420011058 DNA binding site [nucleotide binding] 692420011059 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420011060 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420011061 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420011062 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 692420011063 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 692420011064 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 692420011065 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420011066 protein binding site [polypeptide binding]; other site 692420011067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420011068 YycH protein; Region: YycI; cl02015 692420011069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 692420011070 YycH protein; Region: YycH; pfam07435 692420011071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 692420011072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420011073 dimerization interface [polypeptide binding]; other site 692420011074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 692420011075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420011076 dimer interface [polypeptide binding]; other site 692420011077 phosphorylation site [posttranslational modification] 692420011078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011079 ATP binding site [chemical binding]; other site 692420011080 Mg2+ binding site [ion binding]; other site 692420011081 G-X-G motif; other site 692420011082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420011083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011084 active site 692420011085 phosphorylation site [posttranslational modification] 692420011086 intermolecular recognition site; other site 692420011087 dimerization interface [polypeptide binding]; other site 692420011088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420011089 DNA binding site [nucleotide binding] 692420011090 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 692420011091 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 692420011092 GDP-binding site [chemical binding]; other site 692420011093 ACT binding site; other site 692420011094 IMP binding site; other site 692420011095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420011096 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 692420011097 active site 692420011098 metal binding site [ion binding]; metal-binding site 692420011099 replicative DNA helicase; Provisional; Region: PRK05748 692420011100 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 692420011101 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 692420011102 Walker A motif; other site 692420011103 ATP binding site [chemical binding]; other site 692420011104 Walker B motif; other site 692420011105 DNA binding loops [nucleotide binding] 692420011106 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 692420011107 YycC-like protein; Region: YycC; pfam14174 692420011108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420011109 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 692420011110 Phosphotransferase enzyme family; Region: APH; pfam01636 692420011111 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420011112 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 692420011113 ATP-grasp domain; Region: ATP-grasp_4; cl03087 692420011114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420011115 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 692420011116 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 692420011117 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 692420011118 active site 692420011119 substrate binding site [chemical binding]; other site 692420011120 ATP binding site [chemical binding]; other site 692420011121 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 692420011122 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 692420011123 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 692420011124 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 692420011125 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 692420011126 DHH family; Region: DHH; pfam01368 692420011127 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 692420011128 Coat F domain; Region: Coat_F; cl15836 692420011129 Helix-turn-helix domains; Region: HTH; cl00088 692420011130 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 692420011131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 692420011132 DHHA2 domain; Region: DHHA2; pfam02833 692420011133 EamA-like transporter family; Region: EamA; cl01037 692420011134 EamA-like transporter family; Region: EamA; cl01037 692420011135 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 692420011136 active site 692420011137 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 692420011138 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420011139 substrate binding [chemical binding]; other site 692420011140 active site 692420011141 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420011142 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 692420011143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420011144 DNA-binding site [nucleotide binding]; DNA binding site 692420011145 FCD domain; Region: FCD; cl11656 692420011146 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 692420011147 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420011148 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 692420011149 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420011150 dimer interface [polypeptide binding]; other site 692420011151 FMN binding site [chemical binding]; other site 692420011152 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420011153 Helix-turn-helix domains; Region: HTH; cl00088 692420011154 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420011155 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420011156 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 692420011157 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420011158 Helix-turn-helix domains; Region: HTH; cl00088 692420011159 Predicted acetyltransferase [General function prediction only]; Region: COG3153 692420011160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011161 Coenzyme A binding pocket [chemical binding]; other site 692420011162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420011163 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420011164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 692420011165 potential frameshift: common BLAST hit: gi|154688185|ref|YP_001423346.1| YyaL 692420011166 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 692420011167 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 692420011168 catalytic residues [active] 692420011169 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 692420011170 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 692420011171 CAAX protease self-immunity; Region: Abi; cl00558 692420011172 benzoate transport; Region: 2A0115; TIGR00895 692420011173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011174 putative substrate translocation pore; other site 692420011175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011176 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 692420011177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420011178 putative metal binding site [ion binding]; other site 692420011179 potential frameshift: common BLAST hit: gi|154688189|ref|YP_001423350.1| CcpB 692420011180 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420011181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420011182 DNA binding site [nucleotide binding] 692420011183 domain linker motif; other site 692420011184 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420011185 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 692420011186 active site 692420011187 DNA binding site [nucleotide binding] 692420011188 putative phosphate binding site [ion binding]; other site 692420011189 putative catalytic site [active] 692420011190 metal binding site A [ion binding]; metal-binding site 692420011191 AP binding site [nucleotide binding]; other site 692420011192 metal binding site B [ion binding]; metal-binding site 692420011193 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 692420011194 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 692420011195 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420011196 DNA binding site [nucleotide binding] 692420011197 active site 692420011198 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 692420011199 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 692420011200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420011201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420011202 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 692420011203 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 692420011204 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 692420011205 dimer interface [polypeptide binding]; other site 692420011206 ssDNA binding site [nucleotide binding]; other site 692420011207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420011208 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 692420011209 GTP-binding protein YchF; Reviewed; Region: PRK09601 692420011210 YchF GTPase; Region: YchF; cd01900 692420011211 G1 box; other site 692420011212 GTP/Mg2+ binding site [chemical binding]; other site 692420011213 Switch I region; other site 692420011214 G2 box; other site 692420011215 Switch II region; other site 692420011216 G3 box; other site 692420011217 G4 box; other site 692420011218 G5 box; other site 692420011219 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 692420011220 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 692420011221 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 692420011222 putative [4Fe-4S] binding site [ion binding]; other site 692420011223 putative molybdopterin cofactor binding site [chemical binding]; other site 692420011224 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 692420011225 molybdopterin cofactor binding site; other site 692420011226 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 692420011227 Uncharacterized membrane protein [Function unknown]; Region: COG3949 692420011228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420011229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011230 Coenzyme A binding pocket [chemical binding]; other site 692420011231 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 692420011232 ParB-like partition proteins; Region: parB_part; TIGR00180 692420011233 ParB-like nuclease domain; Region: ParBc; cl02129 692420011234 KorB domain; Region: KorB; pfam08535 692420011235 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 692420011236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 692420011237 ParB-like partition proteins; Region: parB_part; TIGR00180 692420011238 ParB-like nuclease domain; Region: ParBc; cl02129 692420011239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420011240 S-adenosylmethionine binding site [chemical binding]; other site 692420011241 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 692420011242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420011243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420011244 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 692420011245 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 692420011246 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 692420011247 trmE is a tRNA modification GTPase; Region: trmE; cd04164 692420011248 G1 box; other site 692420011249 GTP/Mg2+ binding site [chemical binding]; other site 692420011250 Switch I region; other site 692420011251 G2 box; other site 692420011252 Switch II region; other site 692420011253 G3 box; other site 692420011254 G4 box; other site 692420011255 G5 box; other site 692420011256 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 692420011257 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 692420011258 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 692420011259 G-X-X-G motif; other site 692420011260 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 692420011261 RxxxH motif; other site 692420011262 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 692420011263 Ribonuclease P; Region: Ribonuclease_P; cl00457 692420011264 Ribosomal protein L34; Region: Ribosomal_L34; cl00370