-- dump date 20120504_133752 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1034836000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1034836000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1034836000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836000004 Walker A motif; other site 1034836000005 ATP binding site [chemical binding]; other site 1034836000006 Walker B motif; other site 1034836000007 arginine finger; other site 1034836000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1034836000009 DnaA box-binding interface [nucleotide binding]; other site 1034836000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1034836000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1034836000012 putative DNA binding surface [nucleotide binding]; other site 1034836000013 dimer interface [polypeptide binding]; other site 1034836000014 beta-clamp/clamp loader binding surface; other site 1034836000015 beta-clamp/translesion DNA polymerase binding surface; other site 1034836000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1034836000017 recombination protein F; Reviewed; Region: recF; PRK00064 1034836000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1034836000019 Walker A/P-loop; other site 1034836000020 ATP binding site [chemical binding]; other site 1034836000021 Q-loop/lid; other site 1034836000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836000023 ABC transporter signature motif; other site 1034836000024 Walker B; other site 1034836000025 D-loop; other site 1034836000026 H-loop/switch region; other site 1034836000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1034836000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836000029 ATP binding site [chemical binding]; other site 1034836000030 Mg2+ binding site [ion binding]; other site 1034836000031 G-X-G motif; other site 1034836000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1034836000033 anchoring element; other site 1034836000034 dimer interface [polypeptide binding]; other site 1034836000035 ATP binding site [chemical binding]; other site 1034836000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1034836000037 active site 1034836000038 putative metal-binding site [ion binding]; other site 1034836000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1034836000040 DNA gyrase subunit A; Validated; Region: PRK05560 1034836000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1034836000042 CAP-like domain; other site 1034836000043 active site 1034836000044 primary dimer interface [polypeptide binding]; other site 1034836000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836000051 YaaC-like Protein; Region: YaaC; pfam14175 1034836000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1034836000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1034836000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1034836000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1034836000056 active site 1034836000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1034836000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1034836000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1034836000061 active site 1034836000062 multimer interface [polypeptide binding]; other site 1034836000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1034836000064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1034836000065 predicted active site [active] 1034836000066 catalytic triad [active] 1034836000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1034836000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1034836000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1034836000070 dimer interface [polypeptide binding]; other site 1034836000071 active site 1034836000072 motif 1; other site 1034836000073 motif 2; other site 1034836000074 motif 3; other site 1034836000075 Glycerate kinase family; Region: Gly_kinase; cl00841 1034836000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1034836000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1034836000078 Substrate-binding site [chemical binding]; other site 1034836000079 Substrate specificity [chemical binding]; other site 1034836000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1034836000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1034836000082 Substrate-binding site [chemical binding]; other site 1034836000083 Substrate specificity [chemical binding]; other site 1034836000084 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1034836000085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836000087 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1034836000088 active site 1034836000089 Isochorismatase family; Region: Isochorismatase; pfam00857 1034836000090 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1034836000091 catalytic triad [active] 1034836000092 conserved cis-peptide bond; other site 1034836000093 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1034836000094 nucleoside/Zn binding site; other site 1034836000095 dimer interface [polypeptide binding]; other site 1034836000096 catalytic motif [active] 1034836000097 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1034836000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836000099 Walker A motif; other site 1034836000100 ATP binding site [chemical binding]; other site 1034836000101 Walker B motif; other site 1034836000102 arginine finger; other site 1034836000103 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1034836000104 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1034836000105 recombination protein RecR; Reviewed; Region: recR; PRK00076 1034836000106 RecR protein; Region: RecR; pfam02132 1034836000107 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1034836000108 putative active site [active] 1034836000109 putative metal-binding site [ion binding]; other site 1034836000110 tetramer interface [polypeptide binding]; other site 1034836000111 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1034836000112 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 1034836000113 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1034836000114 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1034836000115 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1034836000116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1034836000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1034836000118 homodimer interface [polypeptide binding]; other site 1034836000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836000120 catalytic residue [active] 1034836000121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1034836000122 thymidylate kinase; Validated; Region: tmk; PRK00698 1034836000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1034836000124 TMP-binding site; other site 1034836000125 ATP-binding site [chemical binding]; other site 1034836000126 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1034836000127 Protein of unknown function (DUF327); Region: DUF327; cl00753 1034836000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1034836000129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836000130 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1034836000131 TSC-22/dip/bun family; Region: TSC22; cl01853 1034836000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1034836000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836000134 S-adenosylmethionine binding site [chemical binding]; other site 1034836000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1034836000136 GIY-YIG motif/motif A; other site 1034836000137 putative active site [active] 1034836000138 putative metal binding site [ion binding]; other site 1034836000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 1034836000140 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1034836000141 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1034836000142 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1034836000143 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1034836000144 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1034836000145 active site 1034836000146 HIGH motif; other site 1034836000147 KMSKS motif; other site 1034836000148 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1034836000149 tRNA binding surface [nucleotide binding]; other site 1034836000150 anticodon binding site; other site 1034836000151 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1034836000152 dimer interface [polypeptide binding]; other site 1034836000153 putative tRNA-binding site [nucleotide binding]; other site 1034836000154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1034836000155 active site 1034836000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1034836000157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1034836000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1034836000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1034836000160 G5 domain; Region: G5; pfam07501 1034836000161 3D domain; Region: 3D; cl01439 1034836000162 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1034836000163 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1034836000164 putative active site [active] 1034836000165 putative metal binding site [ion binding]; other site 1034836000166 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1034836000167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836000168 S-adenosylmethionine binding site [chemical binding]; other site 1034836000169 YabG peptidase U57; Region: Peptidase_U57; cl05250 1034836000170 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 1034836000171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1034836000172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1034836000173 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034836000174 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034836000175 pur operon repressor; Provisional; Region: PRK09213 1034836000176 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1034836000177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836000178 active site 1034836000179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1034836000180 homotrimer interaction site [polypeptide binding]; other site 1034836000181 putative active site [active] 1034836000182 SpoVG; Region: SpoVG; cl00915 1034836000183 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1034836000184 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1034836000185 Substrate binding site; other site 1034836000186 Mg++ binding site; other site 1034836000187 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1034836000188 active site 1034836000189 substrate binding site [chemical binding]; other site 1034836000190 CoA binding site [chemical binding]; other site 1034836000191 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1034836000192 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1034836000193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836000194 active site 1034836000195 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1034836000196 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1034836000197 5S rRNA interface [nucleotide binding]; other site 1034836000198 CTC domain interface [polypeptide binding]; other site 1034836000199 L16 interface [polypeptide binding]; other site 1034836000200 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1034836000201 putative active site [active] 1034836000202 catalytic residue [active] 1034836000203 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1034836000204 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1034836000205 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1034836000206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836000207 ATP binding site [chemical binding]; other site 1034836000208 putative Mg++ binding site [ion binding]; other site 1034836000209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836000210 nucleotide binding region [chemical binding]; other site 1034836000211 ATP-binding site [chemical binding]; other site 1034836000212 TRCF domain; Region: TRCF; cl04088 1034836000213 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1034836000214 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1034836000215 MatE; Region: MatE; cl10513 1034836000216 MatE; Region: MatE; cl10513 1034836000217 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1034836000218 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1034836000219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1034836000220 homodimer interface [polypeptide binding]; other site 1034836000221 metal binding site [ion binding]; metal-binding site 1034836000222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 1034836000223 homodimer interface [polypeptide binding]; other site 1034836000224 active site 1034836000225 putative chemical substrate binding site [chemical binding]; other site 1034836000226 metal binding site [ion binding]; metal-binding site 1034836000227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836000228 RNA binding surface [nucleotide binding]; other site 1034836000229 YabP family; Region: YabP; cl06766 1034836000230 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1034836000231 Septum formation initiator; Region: DivIC; cl11433 1034836000232 hypothetical protein; Provisional; Region: PRK08582 1034836000233 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1034836000234 RNA binding site [nucleotide binding]; other site 1034836000235 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1034836000236 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1034836000237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1034836000238 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1034836000239 metal ion-dependent adhesion site (MIDAS); other site 1034836000240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836000241 active site 1034836000242 ATP binding site [chemical binding]; other site 1034836000243 substrate binding site [chemical binding]; other site 1034836000244 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1034836000245 Ligand Binding Site [chemical binding]; other site 1034836000246 B3/4 domain; Region: B3_4; cl11458 1034836000247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836000248 active site 1034836000249 FtsH Extracellular; Region: FtsH_ext; pfam06480 1034836000250 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1034836000251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836000252 Walker A motif; other site 1034836000253 ATP binding site [chemical binding]; other site 1034836000254 Walker B motif; other site 1034836000255 arginine finger; other site 1034836000256 Peptidase family M41; Region: Peptidase_M41; pfam01434 1034836000257 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1034836000258 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1034836000259 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1034836000260 dimerization interface [polypeptide binding]; other site 1034836000261 domain crossover interface; other site 1034836000262 redox-dependent activation switch; other site 1034836000263 SurA N-terminal domain; Region: SurA_N_3; cl07813 1034836000264 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1034836000265 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1034836000266 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1034836000267 dimer interface [polypeptide binding]; other site 1034836000268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836000269 catalytic residue [active] 1034836000270 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1034836000271 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1034836000272 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1034836000273 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1034836000274 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1034836000275 glutamine binding [chemical binding]; other site 1034836000276 catalytic triad [active] 1034836000277 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1034836000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836000279 catalytic residue [active] 1034836000280 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1034836000281 dihydropteroate synthase; Region: DHPS; TIGR01496 1034836000282 substrate binding pocket [chemical binding]; other site 1034836000283 dimer interface [polypeptide binding]; other site 1034836000284 inhibitor binding site; inhibition site 1034836000285 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1034836000286 homooctamer interface [polypeptide binding]; other site 1034836000287 active site 1034836000288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1034836000289 catalytic center binding site [active] 1034836000290 ATP binding site [chemical binding]; other site 1034836000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836000292 non-specific DNA binding site [nucleotide binding]; other site 1034836000293 salt bridge; other site 1034836000294 sequence-specific DNA binding site [nucleotide binding]; other site 1034836000295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1034836000296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1034836000297 FMN binding site [chemical binding]; other site 1034836000298 active site 1034836000299 catalytic residues [active] 1034836000300 substrate binding site [chemical binding]; other site 1034836000301 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1034836000302 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1034836000303 dimer interface [polypeptide binding]; other site 1034836000304 putative anticodon binding site; other site 1034836000305 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1034836000306 motif 1; other site 1034836000307 active site 1034836000308 motif 2; other site 1034836000309 motif 3; other site 1034836000310 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 1034836000311 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1034836000312 UvrB/uvrC motif; Region: UVR; pfam02151 1034836000313 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1034836000314 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1034836000315 ADP binding site [chemical binding]; other site 1034836000316 phosphagen binding site; other site 1034836000317 substrate specificity loop; other site 1034836000318 Clp protease ATP binding subunit; Region: clpC; CHL00095 1034836000319 Clp amino terminal domain; Region: Clp_N; pfam02861 1034836000320 Clp amino terminal domain; Region: Clp_N; pfam02861 1034836000321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836000322 Walker A motif; other site 1034836000323 ATP binding site [chemical binding]; other site 1034836000324 Walker B motif; other site 1034836000325 arginine finger; other site 1034836000326 UvrB/uvrC motif; Region: UVR; pfam02151 1034836000327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836000328 Walker A motif; other site 1034836000329 ATP binding site [chemical binding]; other site 1034836000330 Walker B motif; other site 1034836000331 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1034836000332 DNA repair protein RadA; Provisional; Region: PRK11823 1034836000333 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1034836000334 Walker A motif/ATP binding site; other site 1034836000335 ATP binding site [chemical binding]; other site 1034836000336 Walker B motif; other site 1034836000337 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1034836000338 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1034836000339 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1034836000340 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1034836000341 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1034836000342 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1034836000343 putative active site [active] 1034836000344 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1034836000345 substrate binding site; other site 1034836000346 dimer interface; other site 1034836000347 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1034836000348 homotrimer interaction site [polypeptide binding]; other site 1034836000349 zinc binding site [ion binding]; other site 1034836000350 CDP-binding sites; other site 1034836000351 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1034836000352 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1034836000353 HIGH motif; other site 1034836000354 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1034836000355 active site 1034836000356 KMSKS motif; other site 1034836000357 serine O-acetyltransferase; Region: cysE; TIGR01172 1034836000358 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1034836000359 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1034836000360 trimer interface [polypeptide binding]; other site 1034836000361 active site 1034836000362 substrate binding site [chemical binding]; other site 1034836000363 CoA binding site [chemical binding]; other site 1034836000364 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1034836000365 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1034836000366 active site 1034836000367 HIGH motif; other site 1034836000368 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1034836000369 KMSKS motif; other site 1034836000370 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1034836000371 tRNA binding surface [nucleotide binding]; other site 1034836000372 anticodon binding site; other site 1034836000373 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1034836000374 active site 1034836000375 metal binding site [ion binding]; metal-binding site 1034836000376 dimerization interface [polypeptide binding]; other site 1034836000377 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1034836000378 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1034836000379 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1034836000380 YacP-like NYN domain; Region: NYN_YacP; cl01491 1034836000381 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1034836000382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836000383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836000384 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1034836000385 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1034836000386 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1034836000387 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1034836000388 putative homodimer interface [polypeptide binding]; other site 1034836000389 KOW motif; Region: KOW; cl00354 1034836000390 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1034836000391 L7/L12 interface [polypeptide binding]; other site 1034836000392 23S rRNA interface [nucleotide binding]; other site 1034836000393 L25 interface [polypeptide binding]; other site 1034836000394 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1034836000395 mRNA/rRNA interface [nucleotide binding]; other site 1034836000396 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1034836000397 23S rRNA interface [nucleotide binding]; other site 1034836000398 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1034836000399 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1034836000400 core dimer interface [polypeptide binding]; other site 1034836000401 peripheral dimer interface [polypeptide binding]; other site 1034836000402 L10 interface [polypeptide binding]; other site 1034836000403 L11 interface [polypeptide binding]; other site 1034836000404 putative EF-Tu interaction site [polypeptide binding]; other site 1034836000405 putative EF-G interaction site [polypeptide binding]; other site 1034836000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836000407 S-adenosylmethionine binding site [chemical binding]; other site 1034836000408 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1034836000409 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1034836000410 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1034836000411 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1034836000412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1034836000413 RPB1 interaction site [polypeptide binding]; other site 1034836000414 RPB10 interaction site [polypeptide binding]; other site 1034836000415 RPB11 interaction site [polypeptide binding]; other site 1034836000416 RPB3 interaction site [polypeptide binding]; other site 1034836000417 RPB12 interaction site [polypeptide binding]; other site 1034836000418 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1034836000419 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1034836000420 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1034836000421 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1034836000422 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1034836000423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1034836000424 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1034836000425 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1034836000426 G-loop; other site 1034836000427 DNA binding site [nucleotide binding] 1034836000428 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1034836000429 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1034836000430 elongation factor G; Reviewed; Region: PRK00007 1034836000431 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1034836000432 G1 box; other site 1034836000433 putative GEF interaction site [polypeptide binding]; other site 1034836000434 GTP/Mg2+ binding site [chemical binding]; other site 1034836000435 Switch I region; other site 1034836000436 G2 box; other site 1034836000437 G3 box; other site 1034836000438 Switch II region; other site 1034836000439 G4 box; other site 1034836000440 G5 box; other site 1034836000441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1034836000442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1034836000443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1034836000444 elongation factor Tu; Reviewed; Region: PRK00049 1034836000445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1034836000446 G1 box; other site 1034836000447 GEF interaction site [polypeptide binding]; other site 1034836000448 GTP/Mg2+ binding site [chemical binding]; other site 1034836000449 Switch I region; other site 1034836000450 G2 box; other site 1034836000451 G3 box; other site 1034836000452 Switch II region; other site 1034836000453 G4 box; other site 1034836000454 G5 box; other site 1034836000455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1034836000456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1034836000457 Antibiotic Binding Site [chemical binding]; other site 1034836000458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1034836000459 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1034836000460 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1034836000461 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1034836000462 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1034836000463 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1034836000464 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1034836000465 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1034836000466 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1034836000467 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1034836000468 G-X-X-G motif; other site 1034836000469 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1034836000470 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1034836000471 L27 interface [polypeptide binding]; other site 1034836000472 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1034836000473 23S rRNA interface [nucleotide binding]; other site 1034836000474 putative translocon interaction site; other site 1034836000475 signal recognition particle (SRP54) interaction site; other site 1034836000476 L23 interface [polypeptide binding]; other site 1034836000477 trigger factor interaction site; other site 1034836000478 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1034836000479 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1034836000480 KOW motif; Region: KOW; cl00354 1034836000481 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1034836000482 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1034836000483 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1034836000484 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1034836000485 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1034836000486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1034836000487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1034836000488 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1034836000489 23S rRNA interface [nucleotide binding]; other site 1034836000490 L5 interface [polypeptide binding]; other site 1034836000491 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1034836000492 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1034836000493 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1034836000494 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1034836000495 23S rRNA binding site [nucleotide binding]; other site 1034836000496 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1034836000497 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 1034836000498 SecY translocase; Region: SecY; pfam00344 1034836000499 adenylate kinase; Reviewed; Region: adk; PRK00279 1034836000500 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1034836000501 AMP-binding site [chemical binding]; other site 1034836000502 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1034836000503 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1034836000504 active site 1034836000505 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1034836000506 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1034836000507 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1034836000508 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1034836000509 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1034836000510 alphaNTD homodimer interface [polypeptide binding]; other site 1034836000511 alphaNTD - beta interaction site [polypeptide binding]; other site 1034836000512 alphaNTD - beta' interaction site [polypeptide binding]; other site 1034836000513 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1034836000514 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1034836000515 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1034836000516 Walker A/P-loop; other site 1034836000517 ATP binding site [chemical binding]; other site 1034836000518 Q-loop/lid; other site 1034836000519 ABC transporter signature motif; other site 1034836000520 Walker B; other site 1034836000521 D-loop; other site 1034836000522 H-loop/switch region; other site 1034836000523 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1034836000524 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1034836000525 Walker A/P-loop; other site 1034836000526 ATP binding site [chemical binding]; other site 1034836000527 Q-loop/lid; other site 1034836000528 ABC transporter signature motif; other site 1034836000529 Walker B; other site 1034836000530 D-loop; other site 1034836000531 H-loop/switch region; other site 1034836000532 Cobalt transport protein; Region: CbiQ; cl00463 1034836000533 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1034836000534 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1034836000535 dimerization interface 3.5A [polypeptide binding]; other site 1034836000536 active site 1034836000537 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1034836000538 23S rRNA interface [nucleotide binding]; other site 1034836000539 L3 interface [polypeptide binding]; other site 1034836000540 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034836000541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836000542 S-adenosylmethionine binding site [chemical binding]; other site 1034836000543 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1034836000544 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034836000545 active site 1034836000546 metal binding site [ion binding]; metal-binding site 1034836000547 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1034836000548 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1034836000549 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1034836000550 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1034836000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000552 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1034836000553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836000554 inhibitor-cofactor binding pocket; inhibition site 1034836000555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836000556 catalytic residue [active] 1034836000557 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1034836000558 active site 1034836000559 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034836000560 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1034836000561 NAD(P) binding site [chemical binding]; other site 1034836000562 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1034836000563 Sulfate transporter family; Region: Sulfate_transp; cl15842 1034836000564 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1034836000565 Sulfate transporter family; Region: Sulfate_transp; cl15842 1034836000566 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1034836000567 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1034836000568 Membrane transport protein; Region: Mem_trans; cl09117 1034836000569 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836000570 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836000571 ABC-ATPase subunit interface; other site 1034836000572 dimer interface [polypeptide binding]; other site 1034836000573 putative PBP binding regions; other site 1034836000574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836000575 ABC-ATPase subunit interface; other site 1034836000576 dimer interface [polypeptide binding]; other site 1034836000577 putative PBP binding regions; other site 1034836000578 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1034836000579 putative ligand binding residues [chemical binding]; other site 1034836000580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836000581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034836000582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836000583 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034836000584 intersubunit interface [polypeptide binding]; other site 1034836000585 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1034836000586 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1034836000587 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1034836000588 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1034836000589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836000590 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1034836000591 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1034836000592 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836000593 active site turn [active] 1034836000594 phosphorylation site [posttranslational modification] 1034836000595 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836000596 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1034836000597 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1034836000598 putative active site [active] 1034836000599 Protein of unknown function (DUF523); Region: DUF523; cl00733 1034836000600 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1034836000601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836000602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836000603 DNA binding residues [nucleotide binding] 1034836000604 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1034836000605 Putative zinc-finger; Region: zf-HC2; cl15806 1034836000606 TIGR00159 family protein; Region: TIGR00159 1034836000607 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1034836000608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1034836000609 YbbR-like protein; Region: YbbR; pfam07949 1034836000610 YbbR-like protein; Region: YbbR; pfam07949 1034836000611 YbbR-like protein; Region: YbbR; pfam07949 1034836000612 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1034836000613 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1034836000614 active site 1034836000615 substrate binding site [chemical binding]; other site 1034836000616 metal binding site [ion binding]; metal-binding site 1034836000617 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1034836000618 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1034836000619 glutaminase active site [active] 1034836000620 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1034836000621 dimer interface [polypeptide binding]; other site 1034836000622 active site 1034836000623 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1034836000624 dimer interface [polypeptide binding]; other site 1034836000625 active site 1034836000626 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1034836000627 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1034836000628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836000629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034836000630 active site 1034836000631 catalytic tetrad [active] 1034836000632 LrgB-like family; Region: LrgB; cl00596 1034836000633 LrgA family; Region: LrgA; cl00608 1034836000634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836000635 Helix-turn-helix domains; Region: HTH; cl00088 1034836000636 putative transport protein YifK; Provisional; Region: PRK10746 1034836000637 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1034836000638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836000639 active site 1034836000640 motif I; other site 1034836000641 motif II; other site 1034836000642 Histidine kinase; Region: HisKA_3; pfam07730 1034836000643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1034836000644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836000645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836000646 active site 1034836000647 phosphorylation site [posttranslational modification] 1034836000648 intermolecular recognition site; other site 1034836000649 dimerization interface [polypeptide binding]; other site 1034836000650 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836000651 DNA binding residues [nucleotide binding] 1034836000652 dimerization interface [polypeptide binding]; other site 1034836000653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034836000654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836000655 Walker A/P-loop; other site 1034836000656 ATP binding site [chemical binding]; other site 1034836000657 Q-loop/lid; other site 1034836000658 ABC transporter signature motif; other site 1034836000659 Walker B; other site 1034836000660 D-loop; other site 1034836000661 H-loop/switch region; other site 1034836000662 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1034836000663 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836000664 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1034836000665 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836000666 potential frameshift: common BLAST hit: gi|154684725|ref|YP_001419886.1| YqeB 1034836000667 Spore germination protein; Region: Spore_permease; cl15802 1034836000668 amino acid transporter; Region: 2A0306; TIGR00909 1034836000669 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1034836000670 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1034836000671 active site 1034836000672 catalytic site [active] 1034836000673 metal binding site [ion binding]; metal-binding site 1034836000674 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1034836000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000676 putative substrate translocation pore; other site 1034836000677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000678 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1034836000679 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1034836000680 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1034836000681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836000682 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1034836000683 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1034836000684 active site 1034836000685 NAD binding site [chemical binding]; other site 1034836000686 metal binding site [ion binding]; metal-binding site 1034836000687 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1034836000688 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836000689 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836000690 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1034836000691 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836000692 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1034836000693 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1034836000694 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1034836000695 active site residue [active] 1034836000696 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1034836000697 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1034836000698 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1034836000699 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1034836000700 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1034836000701 homodimer interface [polypeptide binding]; other site 1034836000702 substrate-cofactor binding pocket; other site 1034836000703 catalytic residue [active] 1034836000704 S-methylmethionine transporter; Provisional; Region: PRK11387 1034836000705 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1034836000706 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1034836000707 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1034836000708 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1034836000709 Glutaminase; Region: Glutaminase; cl00907 1034836000710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034836000711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836000712 ATP binding site [chemical binding]; other site 1034836000713 Mg2+ binding site [ion binding]; other site 1034836000714 G-X-G motif; other site 1034836000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836000716 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836000717 active site 1034836000718 phosphorylation site [posttranslational modification] 1034836000719 intermolecular recognition site; other site 1034836000720 dimerization interface [polypeptide binding]; other site 1034836000721 YcbB domain; Region: YcbB; pfam08664 1034836000722 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1034836000723 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 1034836000724 putative active site [active] 1034836000725 putative substrate binding site [chemical binding]; other site 1034836000726 ATP binding site [chemical binding]; other site 1034836000727 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1034836000728 dodecamer interface 1 [polypeptide binding]; other site 1034836000729 dodecamer interface 2 [polypeptide binding]; other site 1034836000730 trimer interface [polypeptide binding]; other site 1034836000731 TRAP binding interface [polypeptide binding]; other site 1034836000732 Zn binding site [ion binding]; other site 1034836000733 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034836000734 Cation efflux family; Region: Cation_efflux; cl00316 1034836000735 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1034836000736 dimer interface [polypeptide binding]; other site 1034836000737 FMN binding site [chemical binding]; other site 1034836000738 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1034836000739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836000740 Zn binding site [ion binding]; other site 1034836000741 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1034836000742 Zn binding site [ion binding]; other site 1034836000743 DoxX; Region: DoxX; cl00976 1034836000744 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034836000745 catalytic residues [active] 1034836000746 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1034836000747 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1034836000748 PhoD-like phosphatase; Region: PhoD; pfam09423 1034836000749 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1034836000750 putative active site [active] 1034836000751 putative metal binding site [ion binding]; other site 1034836000752 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1034836000753 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1034836000754 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1034836000755 putative substrate binding pocket [chemical binding]; other site 1034836000756 AC domain interface; other site 1034836000757 catalytic triad [active] 1034836000758 AB domain interface; other site 1034836000759 interchain disulfide; other site 1034836000760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1034836000761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836000762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836000763 catalytic residue [active] 1034836000764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836000766 putative substrate translocation pore; other site 1034836000767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836000768 Helix-turn-helix domains; Region: HTH; cl00088 1034836000769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836000770 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1034836000771 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1034836000772 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1034836000773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836000774 active site 1034836000775 catalytic tetrad [active] 1034836000776 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1034836000777 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1034836000778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836000779 binding surface 1034836000780 TPR motif; other site 1034836000781 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1034836000782 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1034836000783 NAD binding site [chemical binding]; other site 1034836000784 homodimer interface [polypeptide binding]; other site 1034836000785 active site 1034836000786 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1034836000787 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1034836000788 Ca binding site [ion binding]; other site 1034836000789 active site 1034836000790 catalytic site [active] 1034836000791 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836000792 Helix-turn-helix domains; Region: HTH; cl00088 1034836000793 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1034836000794 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1034836000795 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1034836000796 metal binding site [ion binding]; metal-binding site 1034836000797 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1034836000798 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1034836000799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836000800 ABC-ATPase subunit interface; other site 1034836000801 dimer interface [polypeptide binding]; other site 1034836000802 putative PBP binding regions; other site 1034836000803 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1034836000804 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034836000805 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1034836000806 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1034836000807 putative metal binding site [ion binding]; other site 1034836000808 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1034836000809 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1034836000810 putative metal binding site [ion binding]; other site 1034836000811 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1034836000812 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1034836000813 putative metal binding site [ion binding]; other site 1034836000814 Integral membrane protein TerC family; Region: TerC; cl10468 1034836000815 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1034836000816 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1034836000817 benzoate transport; Region: 2A0115; TIGR00895 1034836000818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000819 putative substrate translocation pore; other site 1034836000820 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1034836000821 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1034836000822 Walker A/P-loop; other site 1034836000823 ATP binding site [chemical binding]; other site 1034836000824 Q-loop/lid; other site 1034836000825 ABC transporter signature motif; other site 1034836000826 Walker B; other site 1034836000827 D-loop; other site 1034836000828 H-loop/switch region; other site 1034836000829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1034836000830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836000831 dimer interface [polypeptide binding]; other site 1034836000832 conserved gate region; other site 1034836000833 putative PBP binding loops; other site 1034836000834 ABC-ATPase subunit interface; other site 1034836000835 NMT1-like family; Region: NMT1_2; cl15260 1034836000836 NMT1-like family; Region: NMT1_2; cl15260 1034836000837 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1034836000838 amidohydrolase; Region: amidohydrolases; TIGR01891 1034836000839 metal binding site [ion binding]; metal-binding site 1034836000840 putative dimer interface [polypeptide binding]; other site 1034836000841 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1034836000842 RDD family; Region: RDD; cl00746 1034836000843 RDD family; Region: RDD; cl00746 1034836000844 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1034836000845 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1034836000846 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836000847 NAD binding site [chemical binding]; other site 1034836000848 dimer interface [polypeptide binding]; other site 1034836000849 substrate binding site [chemical binding]; other site 1034836000850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836000852 putative substrate translocation pore; other site 1034836000853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836000855 Helix-turn-helix domains; Region: HTH; cl00088 1034836000856 LysE type translocator; Region: LysE; cl00565 1034836000857 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1034836000858 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034836000859 Spore germination protein; Region: Spore_permease; cl15802 1034836000860 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1034836000861 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1034836000862 NAD+ synthetase; Region: nadE; TIGR00552 1034836000863 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1034836000864 homodimer interface [polypeptide binding]; other site 1034836000865 NAD binding pocket [chemical binding]; other site 1034836000866 ATP binding pocket [chemical binding]; other site 1034836000867 Mg binding site [ion binding]; other site 1034836000868 active-site loop [active] 1034836000869 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1034836000870 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1034836000871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836000872 D-galactonate transporter; Region: 2A0114; TIGR00893 1034836000873 putative substrate translocation pore; other site 1034836000874 shikimate kinase; Reviewed; Region: aroK; PRK00131 1034836000875 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1034836000876 ADP binding site [chemical binding]; other site 1034836000877 magnesium binding site [ion binding]; other site 1034836000878 putative shikimate binding site; other site 1034836000879 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1034836000880 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1034836000881 Proline dehydrogenase; Region: Pro_dh; cl03282 1034836000882 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1034836000883 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1034836000884 Glutamate binding site [chemical binding]; other site 1034836000885 homodimer interface [polypeptide binding]; other site 1034836000886 NAD binding site [chemical binding]; other site 1034836000887 catalytic residues [active] 1034836000888 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1034836000889 Na binding site [ion binding]; other site 1034836000890 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1034836000891 Helix-turn-helix domains; Region: HTH; cl00088 1034836000892 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1034836000893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836000894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836000895 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1034836000896 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1034836000897 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1034836000898 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1034836000899 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1034836000900 [2Fe-2S] cluster binding site [ion binding]; other site 1034836000901 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1034836000902 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836000903 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1034836000904 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1034836000905 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034836000906 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1034836000907 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1034836000908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836000909 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1034836000910 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1034836000911 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034836000912 NAD binding site [chemical binding]; other site 1034836000913 catalytic Zn binding site [ion binding]; other site 1034836000914 structural Zn binding site [ion binding]; other site 1034836000915 RDD family; Region: RDD; cl00746 1034836000916 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1034836000917 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034836000918 Competence protein J (ComJ); Region: ComJ; pfam11033 1034836000919 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1034836000920 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1034836000921 tetramer interface [polypeptide binding]; other site 1034836000922 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 1034836000923 active site 1034836000924 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1034836000925 active site 1034836000926 dimer interface [polypeptide binding]; other site 1034836000927 magnesium binding site [ion binding]; other site 1034836000928 Helix-turn-helix domains; Region: HTH; cl00088 1034836000929 peptide synthase; Provisional; Region: PRK12316 1034836000930 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836000931 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000932 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000933 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000934 peptide synthase; Provisional; Region: PRK12316 1034836000935 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836000936 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000937 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000938 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000939 peptide synthase; Provisional; Region: PRK12316 1034836000940 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836000941 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000942 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000943 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836000944 peptide synthase; Provisional; Region: PRK12467 1034836000945 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000946 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000947 peptide synthase; Provisional; Region: PRK12467 1034836000948 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836000949 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000950 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836000952 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000954 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836000955 peptide synthase; Provisional; Region: PRK12467 1034836000956 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000957 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836000958 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836000959 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1034836000960 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1034836000961 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1034836000962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836000963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836000964 homodimer interface [polypeptide binding]; other site 1034836000965 catalytic residue [active] 1034836000966 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1034836000967 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1034836000968 Predicted membrane protein [Function unknown]; Region: COG2364 1034836000969 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836000970 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836000971 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034836000972 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1034836000973 Walker A/P-loop; other site 1034836000974 ATP binding site [chemical binding]; other site 1034836000975 Q-loop/lid; other site 1034836000976 ABC transporter signature motif; other site 1034836000977 Walker B; other site 1034836000978 D-loop; other site 1034836000979 H-loop/switch region; other site 1034836000980 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034836000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836000982 dimer interface [polypeptide binding]; other site 1034836000983 conserved gate region; other site 1034836000984 putative PBP binding loops; other site 1034836000985 ABC-ATPase subunit interface; other site 1034836000986 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1034836000987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836000988 substrate binding pocket [chemical binding]; other site 1034836000989 membrane-bound complex binding site; other site 1034836000990 hinge residues; other site 1034836000991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836000992 Helix-turn-helix domains; Region: HTH; cl00088 1034836000993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836000994 dimerization interface [polypeptide binding]; other site 1034836000995 aromatic acid decarboxylase; Validated; Region: PRK05920 1034836000996 Flavoprotein; Region: Flavoprotein; cl08021 1034836000997 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1034836000998 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1034836000999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1034836001001 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836001002 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1034836001003 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1034836001004 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1034836001005 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1034836001006 Spore germination protein; Region: Spore_permease; cl15802 1034836001007 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1034836001008 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1034836001009 active site 1034836001010 non-prolyl cis peptide bond; other site 1034836001011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001012 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836001013 Coenzyme A binding pocket [chemical binding]; other site 1034836001014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034836001015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836001016 substrate binding pocket [chemical binding]; other site 1034836001017 membrane-bound complex binding site; other site 1034836001018 hinge residues; other site 1034836001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836001020 dimer interface [polypeptide binding]; other site 1034836001021 conserved gate region; other site 1034836001022 putative PBP binding loops; other site 1034836001023 ABC-ATPase subunit interface; other site 1034836001024 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034836001025 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1034836001026 Walker A/P-loop; other site 1034836001027 ATP binding site [chemical binding]; other site 1034836001028 Q-loop/lid; other site 1034836001029 ABC transporter signature motif; other site 1034836001030 Walker B; other site 1034836001031 D-loop; other site 1034836001032 H-loop/switch region; other site 1034836001033 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034836001034 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1034836001035 metal binding site [ion binding]; metal-binding site 1034836001036 dimer interface [polypeptide binding]; other site 1034836001037 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1034836001038 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034836001039 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1034836001040 Walker A/P-loop; other site 1034836001041 ATP binding site [chemical binding]; other site 1034836001042 Q-loop/lid; other site 1034836001043 ABC transporter signature motif; other site 1034836001044 Walker B; other site 1034836001045 D-loop; other site 1034836001046 H-loop/switch region; other site 1034836001047 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1034836001048 FtsX-like permease family; Region: FtsX; cl15850 1034836001049 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836001050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836001051 active site 1034836001052 phosphorylation site [posttranslational modification] 1034836001053 intermolecular recognition site; other site 1034836001054 dimerization interface [polypeptide binding]; other site 1034836001055 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836001056 DNA binding site [nucleotide binding] 1034836001057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836001058 dimerization interface [polypeptide binding]; other site 1034836001059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836001060 dimer interface [polypeptide binding]; other site 1034836001061 phosphorylation site [posttranslational modification] 1034836001062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001063 ATP binding site [chemical binding]; other site 1034836001064 Mg2+ binding site [ion binding]; other site 1034836001065 G-X-G motif; other site 1034836001066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836001067 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836001068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836001069 TPR motif; other site 1034836001070 binding surface 1034836001071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836001072 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1034836001073 aspartate kinase; Reviewed; Region: PRK09034 1034836001074 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1034836001075 putative catalytic residues [active] 1034836001076 putative nucleotide binding site [chemical binding]; other site 1034836001077 putative aspartate binding site [chemical binding]; other site 1034836001078 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1034836001079 allosteric regulatory residue; other site 1034836001080 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1034836001081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836001082 ABC-ATPase subunit interface; other site 1034836001083 dimer interface [polypeptide binding]; other site 1034836001084 putative PBP binding regions; other site 1034836001085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836001086 ABC-ATPase subunit interface; other site 1034836001087 dimer interface [polypeptide binding]; other site 1034836001088 putative PBP binding regions; other site 1034836001089 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1034836001090 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034836001091 Walker A/P-loop; other site 1034836001092 ATP binding site [chemical binding]; other site 1034836001093 Q-loop/lid; other site 1034836001094 ABC transporter signature motif; other site 1034836001095 Walker B; other site 1034836001096 D-loop; other site 1034836001097 H-loop/switch region; other site 1034836001098 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1034836001099 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1034836001100 putative ligand binding residues [chemical binding]; other site 1034836001101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836001103 putative substrate translocation pore; other site 1034836001104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836001106 Helix-turn-helix domains; Region: HTH; cl00088 1034836001107 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1034836001108 dimer interface [polypeptide binding]; other site 1034836001109 FMN binding site [chemical binding]; other site 1034836001110 NADPH bind site [chemical binding]; other site 1034836001111 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836001112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836001113 dimerization interface [polypeptide binding]; other site 1034836001114 putative DNA binding site [nucleotide binding]; other site 1034836001115 putative Zn2+ binding site [ion binding]; other site 1034836001116 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836001117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001118 DNA-binding site [nucleotide binding]; DNA binding site 1034836001119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836001120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836001121 homodimer interface [polypeptide binding]; other site 1034836001122 catalytic residue [active] 1034836001123 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1034836001124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836001125 inhibitor-cofactor binding pocket; inhibition site 1034836001126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836001127 catalytic residue [active] 1034836001128 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1034836001129 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836001130 tetramerization interface [polypeptide binding]; other site 1034836001131 NAD(P) binding site [chemical binding]; other site 1034836001132 catalytic residues [active] 1034836001133 Sugar transport protein; Region: Sugar_transport; pfam06800 1034836001134 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1034836001135 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1034836001136 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1034836001137 NAD binding site [chemical binding]; other site 1034836001138 homodimer interface [polypeptide binding]; other site 1034836001139 active site 1034836001140 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1034836001141 Bacterial Ig-like domain; Region: Big_5; cl01012 1034836001142 Copper resistance protein D; Region: CopD; cl00563 1034836001143 FixH; Region: FixH; cl01254 1034836001144 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034836001145 Helix-turn-helix domains; Region: HTH; cl00088 1034836001146 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1034836001147 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836001148 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1034836001149 active site 1034836001150 P-loop; other site 1034836001151 phosphorylation site [posttranslational modification] 1034836001152 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034836001153 active site 1034836001154 phosphorylation site [posttranslational modification] 1034836001155 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1034836001156 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1034836001157 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1034836001158 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1034836001159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836001160 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836001161 active site 1034836001162 motif I; other site 1034836001163 motif II; other site 1034836001164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836001165 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1034836001166 putative active site [active] 1034836001167 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1034836001168 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 1034836001169 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1034836001170 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1034836001171 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1034836001172 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1034836001173 Helix-turn-helix domains; Region: HTH; cl00088 1034836001174 Bacterial transcriptional regulator; Region: IclR; pfam01614 1034836001175 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1034836001176 active site 1034836001177 catalytic triad [active] 1034836001178 oxyanion hole [active] 1034836001179 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1034836001180 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836001181 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1034836001182 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1034836001183 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836001184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836001185 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836001186 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034836001187 active site 1034836001188 catalytic tetrad [active] 1034836001189 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034836001190 Helix-turn-helix domains; Region: HTH; cl00088 1034836001191 Helix-turn-helix domains; Region: HTH; cl00088 1034836001192 PRD domain; Region: PRD; cl15445 1034836001193 PRD domain; Region: PRD; cl15445 1034836001194 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034836001195 active site 1034836001196 P-loop; other site 1034836001197 phosphorylation site [posttranslational modification] 1034836001198 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1034836001199 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1034836001200 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836001201 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836001202 short chain dehydrogenase; Provisional; Region: PRK06701 1034836001203 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1034836001204 NAD binding site [chemical binding]; other site 1034836001205 metal binding site [ion binding]; metal-binding site 1034836001206 active site 1034836001207 Cupin domain; Region: Cupin_2; cl09118 1034836001208 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1034836001209 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836001210 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1034836001211 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1034836001212 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1034836001213 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1034836001214 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1034836001215 Helix-turn-helix domains; Region: HTH; cl00088 1034836001216 AsnC family; Region: AsnC_trans_reg; pfam01037 1034836001217 DNA topoisomerase III; Provisional; Region: PRK07726 1034836001218 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1034836001219 active site 1034836001220 putative interdomain interaction site [polypeptide binding]; other site 1034836001221 putative metal-binding site [ion binding]; other site 1034836001222 putative nucleotide binding site [chemical binding]; other site 1034836001223 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1034836001224 domain I; other site 1034836001225 DNA binding groove [nucleotide binding] 1034836001226 phosphate binding site [ion binding]; other site 1034836001227 domain II; other site 1034836001228 domain III; other site 1034836001229 nucleotide binding site [chemical binding]; other site 1034836001230 catalytic site [active] 1034836001231 domain IV; other site 1034836001232 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1034836001233 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1034836001234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1034836001235 metal binding site [ion binding]; metal-binding site 1034836001236 active site 1034836001237 I-site; other site 1034836001238 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1034836001239 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1034836001240 NodB motif; other site 1034836001241 putative active site [active] 1034836001242 putative catalytic site [active] 1034836001243 putative Zn binding site [ion binding]; other site 1034836001244 potential frameshift: common BLAST hit: gi|308172288|ref|YP_003918993.1| glycosyltransferase associated to biofilm formation 1034836001245 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1034836001246 Amino acid permease; Region: AA_permease_2; pfam13520 1034836001247 pyruvate oxidase; Provisional; Region: PRK08611 1034836001248 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1034836001249 PYR/PP interface [polypeptide binding]; other site 1034836001250 dimer interface [polypeptide binding]; other site 1034836001251 tetramer interface [polypeptide binding]; other site 1034836001252 TPP binding site [chemical binding]; other site 1034836001253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1034836001254 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1034836001255 TPP-binding site [chemical binding]; other site 1034836001256 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836001257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001258 Coenzyme A binding pocket [chemical binding]; other site 1034836001259 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1034836001260 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1034836001261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836001262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836001263 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836001264 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 1034836001265 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1034836001266 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836001267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1034836001268 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836001269 EcsC protein family; Region: EcsC; pfam12787 1034836001270 General stress protein [General function prediction only]; Region: GsiB; COG3729 1034836001271 General stress protein [General function prediction only]; Region: GsiB; COG3729 1034836001272 Cupin domain; Region: Cupin_2; cl09118 1034836001273 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1034836001274 dimanganese center [ion binding]; other site 1034836001275 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1034836001276 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1034836001277 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1034836001278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836001279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001280 ATP binding site [chemical binding]; other site 1034836001281 Mg2+ binding site [ion binding]; other site 1034836001282 G-X-G motif; other site 1034836001283 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1034836001284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836001285 active site 1034836001286 phosphorylation site [posttranslational modification] 1034836001287 intermolecular recognition site; other site 1034836001288 dimerization interface [polypeptide binding]; other site 1034836001289 Helix-turn-helix domains; Region: HTH; cl00088 1034836001290 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1034836001291 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836001292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034836001293 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1034836001294 Walker A/P-loop; other site 1034836001295 ATP binding site [chemical binding]; other site 1034836001296 Q-loop/lid; other site 1034836001297 ABC transporter signature motif; other site 1034836001298 Walker B; other site 1034836001299 D-loop; other site 1034836001300 H-loop/switch region; other site 1034836001301 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836001302 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1034836001303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1034836001304 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1034836001305 active site 1034836001306 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1034836001307 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1034836001308 Cation efflux family; Region: Cation_efflux; cl00316 1034836001309 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034836001310 catalytic residues [active] 1034836001311 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1034836001312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1034836001313 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836001314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034836001315 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1034836001316 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836001317 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034836001318 helicase 45; Provisional; Region: PTZ00424 1034836001319 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034836001320 ATP binding site [chemical binding]; other site 1034836001321 Mg++ binding site [ion binding]; other site 1034836001322 motif III; other site 1034836001323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836001324 nucleotide binding region [chemical binding]; other site 1034836001325 ATP-binding site [chemical binding]; other site 1034836001326 Bacterial PH domain; Region: DUF304; cl01348 1034836001327 Predicted membrane protein [Function unknown]; Region: COG3428 1034836001328 Bacterial PH domain; Region: DUF304; cl01348 1034836001329 Bacterial PH domain; Region: DUF304; cl01348 1034836001330 Bacterial PH domain; Region: DUF304; cl01348 1034836001331 Rhomboid family; Region: Rhomboid; cl11446 1034836001332 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1034836001333 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1034836001334 alanine racemase; Region: alr; TIGR00492 1034836001335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1034836001336 active site 1034836001337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034836001338 dimer interface [polypeptide binding]; other site 1034836001339 substrate binding site [chemical binding]; other site 1034836001340 catalytic residues [active] 1034836001341 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1034836001342 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1034836001343 PemK-like protein; Region: PemK; cl00995 1034836001344 Rsbr N terminal; Region: Rsbr_N; pfam08678 1034836001345 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836001346 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836001347 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1034836001348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001349 ATP binding site [chemical binding]; other site 1034836001350 Mg2+ binding site [ion binding]; other site 1034836001351 G-X-G motif; other site 1034836001352 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1034836001353 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1034836001354 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1034836001355 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1034836001356 anti sigma factor interaction site; other site 1034836001357 regulatory phosphorylation site [posttranslational modification]; other site 1034836001358 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1034836001359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001360 ATP binding site [chemical binding]; other site 1034836001361 Mg2+ binding site [ion binding]; other site 1034836001362 G-X-G motif; other site 1034836001363 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1034836001364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836001365 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034836001366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836001367 DNA binding residues [nucleotide binding] 1034836001368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1034836001369 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1034836001370 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1034836001371 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1034836001372 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1034836001373 RNA binding site [nucleotide binding]; other site 1034836001374 SprT homologues; Region: SprT; cl01182 1034836001375 hypothetical protein; Provisional; Region: PRK04351 1034836001376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836001377 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1034836001378 substrate binding pocket [chemical binding]; other site 1034836001379 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836001380 OsmC-like protein; Region: OsmC; cl00767 1034836001381 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1034836001382 Helix-turn-helix domains; Region: HTH; cl00088 1034836001383 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1034836001384 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836001385 Helix-turn-helix domains; Region: HTH; cl00088 1034836001386 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001388 Coenzyme A binding pocket [chemical binding]; other site 1034836001389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836001391 putative substrate translocation pore; other site 1034836001392 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1034836001393 Replication initiation factor; Region: Rep_trans; pfam02486 1034836001394 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836001395 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1034836001396 DNA-binding site [nucleotide binding]; DNA binding site 1034836001397 RNA-binding motif; other site 1034836001398 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1034836001399 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1034836001400 Helix-turn-helix domains; Region: HTH; cl00088 1034836001401 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836001402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001403 DNA-binding site [nucleotide binding]; DNA binding site 1034836001404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836001405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836001406 homodimer interface [polypeptide binding]; other site 1034836001407 catalytic residue [active] 1034836001408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001409 putative substrate translocation pore; other site 1034836001410 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1034836001411 active site 1034836001412 nucleophile elbow; other site 1034836001413 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1034836001414 FAD binding domain; Region: FAD_binding_4; pfam01565 1034836001415 Berberine and berberine like; Region: BBE; pfam08031 1034836001416 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1034836001417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836001418 Cation efflux family; Region: Cation_efflux; cl00316 1034836001419 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034836001420 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836001421 Cupin domain; Region: Cupin_2; cl09118 1034836001422 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836001423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001424 Coenzyme A binding pocket [chemical binding]; other site 1034836001425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034836001426 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1034836001427 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1034836001428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836001429 FeS/SAM binding site; other site 1034836001430 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1034836001431 Membrane transport protein; Region: Mem_trans; cl09117 1034836001432 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1034836001433 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1034836001434 putative NAD(P) binding site [chemical binding]; other site 1034836001435 putative substrate binding site [chemical binding]; other site 1034836001436 catalytic Zn binding site [ion binding]; other site 1034836001437 structural Zn binding site [ion binding]; other site 1034836001438 dimer interface [polypeptide binding]; other site 1034836001439 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1034836001440 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1034836001441 DNA binding residues [nucleotide binding] 1034836001442 putative dimer interface [polypeptide binding]; other site 1034836001443 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1034836001444 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836001445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001446 DNA-binding site [nucleotide binding]; DNA binding site 1034836001447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836001448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836001449 homodimer interface [polypeptide binding]; other site 1034836001450 catalytic residue [active] 1034836001451 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1034836001452 benzoate transport; Region: 2A0115; TIGR00895 1034836001453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836001454 Helix-turn-helix domains; Region: HTH; cl00088 1034836001455 EamA-like transporter family; Region: EamA; cl01037 1034836001456 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1034836001457 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836001458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001459 DNA-binding site [nucleotide binding]; DNA binding site 1034836001460 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836001462 homodimer interface [polypeptide binding]; other site 1034836001463 catalytic residue [active] 1034836001464 Coat F domain; Region: Coat_F; cl15836 1034836001465 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1034836001466 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034836001467 NAD binding site [chemical binding]; other site 1034836001468 catalytic Zn binding site [ion binding]; other site 1034836001469 structural Zn binding site [ion binding]; other site 1034836001470 Coat F domain; Region: Coat_F; cl15836 1034836001471 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1034836001472 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1034836001473 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1034836001474 catalytic triad [active] 1034836001475 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034836001476 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001477 ABC transporter; Region: ABC_tran_2; pfam12848 1034836001478 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034836001480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001481 Coenzyme A binding pocket [chemical binding]; other site 1034836001482 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836001483 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836001484 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836001485 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836001486 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1034836001487 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1034836001488 dimer interface [polypeptide binding]; other site 1034836001489 active site 1034836001490 metal binding site [ion binding]; metal-binding site 1034836001491 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1034836001492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001493 putative substrate translocation pore; other site 1034836001494 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1034836001495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1034836001496 dimer interface [polypeptide binding]; other site 1034836001497 active site 1034836001498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836001499 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1034836001500 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836001501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001502 Coenzyme A binding pocket [chemical binding]; other site 1034836001503 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1034836001504 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034836001505 DNA binding residues [nucleotide binding] 1034836001506 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1034836001507 EamA-like transporter family; Region: EamA; cl01037 1034836001508 EamA-like transporter family; Region: EamA; cl01037 1034836001509 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1034836001510 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1034836001511 nudix motif; other site 1034836001512 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1034836001513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1034836001514 tartrate dehydrogenase; Provisional; Region: PRK08194 1034836001515 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1034836001516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1034836001517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001518 DNA-binding site [nucleotide binding]; DNA binding site 1034836001519 FCD domain; Region: FCD; cl11656 1034836001520 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1034836001521 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1034836001522 active site 1034836001523 TDP-binding site; other site 1034836001524 acceptor substrate-binding pocket; other site 1034836001525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836001526 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1034836001527 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1034836001528 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1034836001529 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001531 putative substrate translocation pore; other site 1034836001532 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034836001533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001534 DNA-binding site [nucleotide binding]; DNA binding site 1034836001535 UTRA domain; Region: UTRA; cl01230 1034836001536 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1034836001537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836001538 DNA-binding site [nucleotide binding]; DNA binding site 1034836001539 FCD domain; Region: FCD; cl11656 1034836001540 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1034836001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001542 putative substrate translocation pore; other site 1034836001543 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836001544 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836001545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836001546 Helix-turn-helix domains; Region: HTH; cl00088 1034836001547 amino acid transporter; Region: 2A0306; TIGR00909 1034836001548 Spore germination protein; Region: Spore_permease; cl15802 1034836001549 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1034836001550 dimanganese center [ion binding]; other site 1034836001551 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1034836001552 putative hydrophobic ligand binding site [chemical binding]; other site 1034836001553 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1034836001554 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1034836001555 putative NADP binding site [chemical binding]; other site 1034836001556 putative dimer interface [polypeptide binding]; other site 1034836001557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001558 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1034836001559 putative substrate translocation pore; other site 1034836001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001561 thiamine monophosphate kinase; Provisional; Region: PRK05731 1034836001562 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1034836001563 ATP binding site [chemical binding]; other site 1034836001564 dimerization interface [polypeptide binding]; other site 1034836001565 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1034836001566 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1034836001567 Glycoprotease family; Region: Peptidase_M22; pfam00814 1034836001568 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1034836001569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836001570 Coenzyme A binding pocket [chemical binding]; other site 1034836001571 UGMP family protein; Validated; Region: PRK09604 1034836001572 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1034836001573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034836001574 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001575 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001576 ABC transporter; Region: ABC_tran_2; pfam12848 1034836001577 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001578 ABC transporter; Region: ABC_tran_2; pfam12848 1034836001579 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1034836001580 trimer interface [polypeptide binding]; other site 1034836001581 dimer interface [polypeptide binding]; other site 1034836001582 putative active site [active] 1034836001583 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1034836001584 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1034836001585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836001586 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1034836001587 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1034836001588 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1034836001589 CAAX protease self-immunity; Region: Abi; cl00558 1034836001590 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1034836001591 oligomerisation interface [polypeptide binding]; other site 1034836001592 mobile loop; other site 1034836001593 roof hairpin; other site 1034836001594 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1034836001595 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1034836001596 ring oligomerisation interface [polypeptide binding]; other site 1034836001597 ATP/Mg binding site [chemical binding]; other site 1034836001598 stacking interactions; other site 1034836001599 hinge regions; other site 1034836001600 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836001601 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1034836001602 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836001603 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1034836001604 active site 1034836001605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836001606 Walker A motif; other site 1034836001607 ATP binding site [chemical binding]; other site 1034836001608 Walker B motif; other site 1034836001609 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1034836001610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836001611 binding surface 1034836001612 TPR motif; other site 1034836001613 TPR repeat; Region: TPR_11; pfam13414 1034836001614 L-idonate 5-dehydrogenase; Region: PLN02702 1034836001615 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1034836001616 inhibitor binding site; inhibition site 1034836001617 catalytic Zn binding site [ion binding]; other site 1034836001618 structural Zn binding site [ion binding]; other site 1034836001619 NADP binding site [chemical binding]; other site 1034836001620 tetramer interface [polypeptide binding]; other site 1034836001621 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1034836001622 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1034836001623 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034836001624 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1034836001625 putative substrate binding site [chemical binding]; other site 1034836001626 putative ATP binding site [chemical binding]; other site 1034836001627 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1034836001628 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1034836001629 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1034836001630 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1034836001631 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1034836001632 Repair protein; Region: Repair_PSII; cl01535 1034836001633 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1034836001634 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1034836001635 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1034836001636 OpgC protein; Region: OpgC_C; cl00792 1034836001637 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1034836001638 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1034836001639 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1034836001640 catalytic triad [active] 1034836001641 catalytic triad [active] 1034836001642 oxyanion hole [active] 1034836001643 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1034836001644 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1034836001645 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1034836001646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836001647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836001648 DNA binding residues [nucleotide binding] 1034836001649 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034836001650 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1034836001651 putative NAD(P) binding site [chemical binding]; other site 1034836001652 catalytic Zn binding site [ion binding]; other site 1034836001653 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1034836001654 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1034836001655 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1034836001656 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1034836001657 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1034836001658 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1034836001659 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1034836001660 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1034836001661 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034836001662 Cation efflux family; Region: Cation_efflux; cl00316 1034836001663 MoxR-like ATPases [General function prediction only]; Region: COG0714 1034836001664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836001665 Walker A motif; other site 1034836001666 ATP binding site [chemical binding]; other site 1034836001667 Walker B motif; other site 1034836001668 arginine finger; other site 1034836001669 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1034836001670 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1034836001671 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1034836001672 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1034836001673 GMP synthase; Reviewed; Region: guaA; PRK00074 1034836001674 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1034836001675 AMP/PPi binding site [chemical binding]; other site 1034836001676 candidate oxyanion hole; other site 1034836001677 catalytic triad [active] 1034836001678 potential glutamine specificity residues [chemical binding]; other site 1034836001679 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1034836001680 ATP Binding subdomain [chemical binding]; other site 1034836001681 Ligand Binding sites [chemical binding]; other site 1034836001682 Dimerization subdomain; other site 1034836001683 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1034836001684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836001685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836001686 DNA binding residues [nucleotide binding] 1034836001687 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1034836001688 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1034836001689 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1034836001690 hypothetical protein; Provisional; Region: PRK04164 1034836001691 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836001692 NETI protein; Region: NETI; pfam14044 1034836001693 AIR carboxylase; Region: AIRC; cl00310 1034836001694 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1034836001695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836001696 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836001697 adenylosuccinate lyase; Provisional; Region: PRK07492 1034836001698 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1034836001699 tetramer interface [polypeptide binding]; other site 1034836001700 active site 1034836001701 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1034836001702 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1034836001703 ATP binding site [chemical binding]; other site 1034836001704 active site 1034836001705 substrate binding site [chemical binding]; other site 1034836001706 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1034836001707 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1034836001708 putative active site [active] 1034836001709 catalytic triad [active] 1034836001710 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1034836001711 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1034836001712 dimerization interface [polypeptide binding]; other site 1034836001713 ATP binding site [chemical binding]; other site 1034836001714 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1034836001715 dimerization interface [polypeptide binding]; other site 1034836001716 ATP binding site [chemical binding]; other site 1034836001717 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1034836001718 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1034836001719 active site 1034836001720 tetramer interface [polypeptide binding]; other site 1034836001721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836001722 active site 1034836001723 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1034836001724 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1034836001725 dimerization interface [polypeptide binding]; other site 1034836001726 putative ATP binding site [chemical binding]; other site 1034836001727 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1034836001728 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1034836001729 active site 1034836001730 substrate binding site [chemical binding]; other site 1034836001731 cosubstrate binding site; other site 1034836001732 catalytic site [active] 1034836001733 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1034836001734 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1034836001735 purine monophosphate binding site [chemical binding]; other site 1034836001736 dimer interface [polypeptide binding]; other site 1034836001737 putative catalytic residues [active] 1034836001738 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1034836001739 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1034836001740 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1034836001741 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1034836001742 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836001743 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1034836001744 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1034836001745 Helix-turn-helix domains; Region: HTH; cl00088 1034836001746 AsnC family; Region: AsnC_trans_reg; pfam01037 1034836001747 putative transporter; Provisional; Region: PRK11021 1034836001748 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1034836001749 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1034836001750 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034836001751 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1034836001752 active site 1034836001753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034836001754 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1034836001755 Helix-turn-helix domains; Region: HTH; cl00088 1034836001756 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1034836001757 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1034836001758 active site 1034836001759 FMN binding site [chemical binding]; other site 1034836001760 substrate binding site [chemical binding]; other site 1034836001761 3Fe-4S cluster binding site [ion binding]; other site 1034836001762 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1034836001763 substrate binding site [chemical binding]; other site 1034836001764 putative active site [active] 1034836001765 dimer interface [polypeptide binding]; other site 1034836001766 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1034836001767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836001768 Family description; Region: UvrD_C_2; cl15862 1034836001769 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1034836001770 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1034836001771 nucleotide binding pocket [chemical binding]; other site 1034836001772 K-X-D-G motif; other site 1034836001773 catalytic site [active] 1034836001774 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1034836001775 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1034836001776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1034836001777 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1034836001778 Dimer interface [polypeptide binding]; other site 1034836001779 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 1034836001780 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836001781 active site 1034836001782 ATP binding site [chemical binding]; other site 1034836001783 substrate binding site [chemical binding]; other site 1034836001784 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1034836001785 MgtC family; Region: MgtC; pfam02308 1034836001786 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1034836001787 Na binding site [ion binding]; other site 1034836001788 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1034836001789 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1034836001790 Amidase; Region: Amidase; cl11426 1034836001791 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1034836001792 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1034836001793 GatB domain; Region: GatB_Yqey; cl11497 1034836001794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836001795 Helix-turn-helix domains; Region: HTH; cl00088 1034836001796 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1034836001797 Protein export membrane protein; Region: SecD_SecF; cl14618 1034836001798 putative lipid kinase; Reviewed; Region: PRK13337 1034836001799 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1034836001800 TRAM domain; Region: TRAM; cl01282 1034836001801 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1034836001802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836001803 S-adenosylmethionine binding site [chemical binding]; other site 1034836001804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836001805 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1034836001806 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1034836001807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034836001808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836001809 Walker A/P-loop; other site 1034836001810 ATP binding site [chemical binding]; other site 1034836001811 Q-loop/lid; other site 1034836001812 ABC transporter signature motif; other site 1034836001813 Walker B; other site 1034836001814 D-loop; other site 1034836001815 H-loop/switch region; other site 1034836001816 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1034836001817 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1034836001818 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034836001819 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034836001820 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034836001821 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836001822 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836001823 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1034836001824 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836001825 Transcriptional regulator; Region: Transcrip_reg; cl00361 1034836001826 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1034836001827 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1034836001828 CotJB protein; Region: CotJB; pfam12652 1034836001829 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1034836001830 dimanganese center [ion binding]; other site 1034836001831 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836001832 YesK-like protein; Region: YesK; pfam14150 1034836001833 Protein of unknown function (DUF421); Region: DUF421; cl00990 1034836001834 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836001835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836001836 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1034836001837 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836001838 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1034836001839 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1034836001840 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836001841 Helix-turn-helix domains; Region: HTH; cl00088 1034836001842 hypothetical protein; Provisional; Region: PRK06847 1034836001843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836001844 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1034836001845 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1034836001846 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836001847 Cytochrome P450; Region: p450; pfam00067 1034836001848 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1034836001849 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836001850 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1034836001851 FAD binding pocket [chemical binding]; other site 1034836001852 FAD binding motif [chemical binding]; other site 1034836001853 catalytic residues [active] 1034836001854 NAD binding pocket [chemical binding]; other site 1034836001855 phosphate binding motif [ion binding]; other site 1034836001856 beta-alpha-beta structure motif; other site 1034836001857 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1034836001858 Sulfatase; Region: Sulfatase; cl10460 1034836001859 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1034836001860 substrate binding site; other site 1034836001861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034836001862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836001863 NAD(P) binding site [chemical binding]; other site 1034836001864 active site 1034836001865 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 1034836001866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836001867 active site 1034836001868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1034836001869 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 1034836001870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836001872 putative substrate translocation pore; other site 1034836001873 Spore germination protein; Region: Spore_permease; cl15802 1034836001874 amino acid transporter; Region: 2A0306; TIGR00909 1034836001875 Spore germination protein; Region: Spore_permease; cl15802 1034836001876 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1034836001877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836001878 NAD(P) binding site [chemical binding]; other site 1034836001879 catalytic residues [active] 1034836001880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836001881 dimer interface [polypeptide binding]; other site 1034836001882 putative CheW interface [polypeptide binding]; other site 1034836001883 oxidoreductase; Provisional; Region: PRK07985 1034836001884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836001885 NAD(P) binding site [chemical binding]; other site 1034836001886 active site 1034836001887 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1034836001888 putative metal binding site; other site 1034836001889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836001890 binding surface 1034836001891 TPR motif; other site 1034836001892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836001893 binding surface 1034836001894 TPR motif; other site 1034836001895 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034836001896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836001897 Walker A/P-loop; other site 1034836001898 ATP binding site [chemical binding]; other site 1034836001899 Q-loop/lid; other site 1034836001900 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001901 ABC transporter; Region: ABC_tran_2; pfam12848 1034836001902 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001903 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1034836001904 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836001905 DNA binding residues [nucleotide binding] 1034836001906 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836001908 putative substrate translocation pore; other site 1034836001909 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034836001910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836001911 Walker A/P-loop; other site 1034836001912 ATP binding site [chemical binding]; other site 1034836001913 Q-loop/lid; other site 1034836001914 ABC transporter signature motif; other site 1034836001915 Walker B; other site 1034836001916 D-loop; other site 1034836001917 H-loop/switch region; other site 1034836001918 ABC transporter; Region: ABC_tran_2; pfam12848 1034836001919 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836001920 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034836001921 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1034836001922 ATP binding site [chemical binding]; other site 1034836001923 Mg++ binding site [ion binding]; other site 1034836001924 motif III; other site 1034836001925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836001926 nucleotide binding region [chemical binding]; other site 1034836001927 ATP-binding site [chemical binding]; other site 1034836001928 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1034836001929 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1034836001930 NAD(P) binding site [chemical binding]; other site 1034836001931 substrate binding site [chemical binding]; other site 1034836001932 dimer interface [polypeptide binding]; other site 1034836001933 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1034836001934 Heat induced stress protein YflT; Region: YflT; pfam11181 1034836001935 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1034836001936 Pectate lyase; Region: Pec_lyase_C; cl01593 1034836001937 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1034836001938 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1034836001939 transmembrane helices; other site 1034836001940 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1034836001941 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1034836001942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034836001943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836001944 dimer interface [polypeptide binding]; other site 1034836001945 phosphorylation site [posttranslational modification] 1034836001946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001947 ATP binding site [chemical binding]; other site 1034836001948 Mg2+ binding site [ion binding]; other site 1034836001949 G-X-G motif; other site 1034836001950 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836001951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836001952 active site 1034836001953 phosphorylation site [posttranslational modification] 1034836001954 intermolecular recognition site; other site 1034836001955 dimerization interface [polypeptide binding]; other site 1034836001956 Histidine kinase; Region: His_kinase; pfam06580 1034836001957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001958 ATP binding site [chemical binding]; other site 1034836001959 Mg2+ binding site [ion binding]; other site 1034836001960 G-X-G motif; other site 1034836001961 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1034836001962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836001963 active site 1034836001964 phosphorylation site [posttranslational modification] 1034836001965 intermolecular recognition site; other site 1034836001966 dimerization interface [polypeptide binding]; other site 1034836001967 Helix-turn-helix domains; Region: HTH; cl00088 1034836001968 Collagen binding domain; Region: Collagen_bind; pfam05737 1034836001969 Collagen binding domain; Region: Collagen_bind; pfam05737 1034836001970 Collagen binding domain; Region: Collagen_bind; pfam05737 1034836001971 Collagen binding domain; Region: Collagen_bind; pfam05737 1034836001972 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001973 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001974 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001975 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001976 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001977 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001978 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001979 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001980 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836001981 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1034836001982 active site 1034836001983 catalytic site [active] 1034836001984 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1034836001985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836001987 ATP binding site [chemical binding]; other site 1034836001988 Mg2+ binding site [ion binding]; other site 1034836001989 G-X-G motif; other site 1034836001990 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1034836001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836001992 active site 1034836001993 phosphorylation site [posttranslational modification] 1034836001994 intermolecular recognition site; other site 1034836001995 dimerization interface [polypeptide binding]; other site 1034836001996 Transcriptional regulator; Region: CitT; pfam12431 1034836001997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1034836001998 NMT1-like family; Region: NMT1_2; cl15260 1034836001999 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1034836002000 Citrate transporter; Region: CitMHS; pfam03600 1034836002001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836002002 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1034836002003 active site 1034836002004 dimer interface [polypeptide binding]; other site 1034836002005 Acylphosphatase; Region: Acylphosphatase; cl00551 1034836002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1034836002007 MOSC domain; Region: MOSC; pfam03473 1034836002008 3-alpha domain; Region: 3-alpha; pfam03475 1034836002009 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1034836002010 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1034836002011 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1034836002012 active site 1034836002013 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1034836002014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836002015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836002016 active site turn [active] 1034836002017 phosphorylation site [posttranslational modification] 1034836002018 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1034836002019 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1034836002020 Sulfatase; Region: Sulfatase; cl10460 1034836002021 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1034836002022 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1034836002023 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1034836002024 putative dimer interface [polypeptide binding]; other site 1034836002025 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836002026 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836002027 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1034836002028 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836002029 active site turn [active] 1034836002030 phosphorylation site [posttranslational modification] 1034836002031 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836002032 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1034836002033 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1034836002034 Ca binding site [ion binding]; other site 1034836002035 active site 1034836002036 catalytic site [active] 1034836002037 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1034836002038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836002039 DNA-binding site [nucleotide binding]; DNA binding site 1034836002040 UTRA domain; Region: UTRA; cl01230 1034836002041 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1034836002042 dimer interface [polypeptide binding]; other site 1034836002043 FMN binding site [chemical binding]; other site 1034836002044 YibE/F-like protein; Region: YibE_F; cl02259 1034836002045 YibE/F-like protein; Region: YibE_F; cl02259 1034836002046 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1034836002047 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1034836002048 active site 1034836002049 metal binding site [ion binding]; metal-binding site 1034836002050 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034836002051 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1034836002052 active site 1034836002053 metal binding site [ion binding]; metal-binding site 1034836002054 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034836002055 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 1034836002056 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1034836002057 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1034836002058 proposed catalytic triad [active] 1034836002059 conserved cys residue [active] 1034836002060 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836002061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836002062 DNA binding site [nucleotide binding] 1034836002063 domain linker motif; other site 1034836002064 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1034836002065 putative dimerization interface [polypeptide binding]; other site 1034836002066 putative ligand binding site [chemical binding]; other site 1034836002067 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1034836002068 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1034836002069 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1034836002070 shikimate binding site; other site 1034836002071 NAD(P) binding site [chemical binding]; other site 1034836002072 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1034836002073 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 1034836002074 active site 1034836002075 catalytic residue [active] 1034836002076 dimer interface [polypeptide binding]; other site 1034836002077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836002079 putative substrate translocation pore; other site 1034836002080 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1034836002081 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1034836002082 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1034836002083 active site 1034836002084 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1034836002085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836002087 putative substrate translocation pore; other site 1034836002088 calcium/proton exchanger (cax); Region: cax; TIGR00378 1034836002089 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1034836002090 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1034836002091 YfkD-like protein; Region: YfkD; pfam14167 1034836002092 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1034836002093 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1034836002094 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1034836002095 YfkB-like domain; Region: YfkB; pfam08756 1034836002096 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1034836002097 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1034836002098 NodB motif; other site 1034836002099 active site 1034836002100 catalytic site [active] 1034836002101 Cd binding site [ion binding]; other site 1034836002102 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1034836002103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002104 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1034836002105 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1034836002106 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1034836002107 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1034836002108 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034836002109 minor groove reading motif; other site 1034836002110 helix-hairpin-helix signature motif; other site 1034836002111 substrate binding pocket [chemical binding]; other site 1034836002112 active site 1034836002113 TRAM domain; Region: TRAM; cl01282 1034836002114 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1034836002115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836002116 S-adenosylmethionine binding site [chemical binding]; other site 1034836002117 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1034836002118 active site 1034836002119 catalytic residues [active] 1034836002120 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836002121 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836002123 Walker A/P-loop; other site 1034836002124 ATP binding site [chemical binding]; other site 1034836002125 Q-loop/lid; other site 1034836002126 ABC transporter signature motif; other site 1034836002127 Walker B; other site 1034836002128 D-loop; other site 1034836002129 H-loop/switch region; other site 1034836002130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836002131 active site 1034836002132 ATP binding site [chemical binding]; other site 1034836002133 substrate binding site [chemical binding]; other site 1034836002134 activation loop (A-loop); other site 1034836002135 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1034836002136 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1034836002137 active site 1034836002138 zinc binding site [ion binding]; other site 1034836002139 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1034836002140 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1034836002141 FMN binding site [chemical binding]; other site 1034836002142 active site 1034836002143 catalytic residues [active] 1034836002144 substrate binding site [chemical binding]; other site 1034836002145 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1034836002146 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034836002147 tetramer interface [polypeptide binding]; other site 1034836002148 TPP-binding site [chemical binding]; other site 1034836002149 heterodimer interface [polypeptide binding]; other site 1034836002150 phosphorylation loop region [posttranslational modification] 1034836002151 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034836002152 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034836002153 alpha subunit interface [polypeptide binding]; other site 1034836002154 TPP binding site [chemical binding]; other site 1034836002155 heterodimer interface [polypeptide binding]; other site 1034836002156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034836002157 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034836002158 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034836002159 E3 interaction surface; other site 1034836002160 lipoyl attachment site [posttranslational modification]; other site 1034836002161 e3 binding domain; Region: E3_binding; pfam02817 1034836002162 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1034836002163 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1034836002164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836002165 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034836002166 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1034836002167 GAF domain; Region: GAF; cl15785 1034836002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836002169 Walker A motif; other site 1034836002170 ATP binding site [chemical binding]; other site 1034836002171 Walker B motif; other site 1034836002172 arginine finger; other site 1034836002173 Helix-turn-helix domains; Region: HTH; cl00088 1034836002174 Small acid-soluble spore protein H family; Region: SspH; cl06949 1034836002175 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1034836002176 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1034836002177 NAD binding site [chemical binding]; other site 1034836002178 sugar binding site [chemical binding]; other site 1034836002179 divalent metal binding site [ion binding]; other site 1034836002180 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836002181 dimer interface [polypeptide binding]; other site 1034836002182 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034836002183 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034836002184 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034836002185 putative active site [active] 1034836002186 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1034836002187 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836002188 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836002189 active site turn [active] 1034836002190 phosphorylation site [posttranslational modification] 1034836002191 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836002192 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1034836002193 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1034836002194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836002195 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836002197 Walker A/P-loop; other site 1034836002198 ATP binding site [chemical binding]; other site 1034836002199 Q-loop/lid; other site 1034836002200 ABC transporter signature motif; other site 1034836002201 Walker B; other site 1034836002202 D-loop; other site 1034836002203 H-loop/switch region; other site 1034836002204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836002205 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002206 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1034836002207 Walker A/P-loop; other site 1034836002208 ATP binding site [chemical binding]; other site 1034836002209 Q-loop/lid; other site 1034836002210 ABC transporter signature motif; other site 1034836002211 Walker B; other site 1034836002212 D-loop; other site 1034836002213 H-loop/switch region; other site 1034836002214 DoxX; Region: DoxX; cl00976 1034836002215 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1034836002216 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1034836002217 putative metal binding site [ion binding]; other site 1034836002218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034836002219 active site 1034836002220 metal binding site [ion binding]; metal-binding site 1034836002221 potential frameshift: common BLAST hit: gi|154685298|ref|YP_001420459.1| CtaO 1034836002222 Helix-turn-helix domains; Region: HTH; cl00088 1034836002223 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1034836002224 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836002225 OpgC protein; Region: OpgC_C; cl00792 1034836002226 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1034836002227 RNAase interaction site [polypeptide binding]; other site 1034836002228 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836002229 DinB superfamily; Region: DinB_2; pfam12867 1034836002230 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836002231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002232 putative substrate translocation pore; other site 1034836002233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002234 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836002235 Helix-turn-helix domains; Region: HTH; cl00088 1034836002236 Predicted integral membrane protein [Function unknown]; Region: COG0392 1034836002237 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1034836002238 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1034836002239 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1034836002240 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1034836002241 putative FMN binding site [chemical binding]; other site 1034836002242 YfhD-like protein; Region: YfhD; pfam14151 1034836002243 YfhE-like protein; Region: YfhE; pfam14152 1034836002244 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1034836002245 TIGR01777 family protein; Region: yfcH 1034836002246 putative NAD(P) binding site [chemical binding]; other site 1034836002247 putative active site [active] 1034836002248 RecX family; Region: RecX; cl00936 1034836002249 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1034836002250 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836002251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002252 putative substrate translocation pore; other site 1034836002253 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1034836002254 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1034836002255 Small acid-soluble spore protein K family; Region: SspK; cl11509 1034836002256 WVELL protein; Region: WVELL; pfam14043 1034836002257 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836002258 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836002259 SdpI/YhfL protein family; Region: SdpI; pfam13630 1034836002260 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836002261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1034836002262 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1034836002263 Ligand binding site; other site 1034836002264 Putative Catalytic site; other site 1034836002265 DXD motif; other site 1034836002266 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1034836002267 Caenorhabditis protein of unknown function, DUF267; Region: DUF267; pfam03268 1034836002268 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1034836002269 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1034836002270 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034836002271 minor groove reading motif; other site 1034836002272 helix-hairpin-helix signature motif; other site 1034836002273 substrate binding pocket [chemical binding]; other site 1034836002274 active site 1034836002275 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1034836002276 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1034836002277 DNA binding and oxoG recognition site [nucleotide binding] 1034836002278 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1034836002279 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1034836002280 putative NAD(P) binding site [chemical binding]; other site 1034836002281 active site 1034836002282 YgaB-like protein; Region: YgaB; pfam14182 1034836002283 Protein of unknown function (DUF402); Region: DUF402; cl00979 1034836002284 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836002285 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002286 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1034836002287 Walker A/P-loop; other site 1034836002288 ATP binding site [chemical binding]; other site 1034836002289 Q-loop/lid; other site 1034836002290 ABC transporter signature motif; other site 1034836002291 Walker B; other site 1034836002292 D-loop; other site 1034836002293 H-loop/switch region; other site 1034836002294 Predicted membrane protein [Function unknown]; Region: COG4129 1034836002295 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1034836002296 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1034836002297 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836002298 inhibitor-cofactor binding pocket; inhibition site 1034836002299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002300 catalytic residue [active] 1034836002301 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1034836002302 catalytic triad [active] 1034836002303 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034836002304 metal binding site 2 [ion binding]; metal-binding site 1034836002305 putative DNA binding helix; other site 1034836002306 metal binding site 1 [ion binding]; metal-binding site 1034836002307 dimer interface [polypeptide binding]; other site 1034836002308 structural Zn2+ binding site [ion binding]; other site 1034836002309 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1034836002310 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1034836002311 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1034836002312 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1034836002313 active site pocket [active] 1034836002314 oxyanion hole [active] 1034836002315 catalytic triad [active] 1034836002316 active site nucleophile [active] 1034836002317 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1034836002318 ThiC-associated domain; Region: ThiC-associated; pfam13667 1034836002319 ThiC family; Region: ThiC; cl08031 1034836002320 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1034836002321 FAD binding domain; Region: FAD_binding_4; pfam01565 1034836002322 Berberine and berberine like; Region: BBE; pfam08031 1034836002323 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1034836002324 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1034836002325 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1034836002326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034836002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836002328 dimer interface [polypeptide binding]; other site 1034836002329 conserved gate region; other site 1034836002330 putative PBP binding loops; other site 1034836002331 ABC-ATPase subunit interface; other site 1034836002332 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1034836002333 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1034836002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836002335 dimer interface [polypeptide binding]; other site 1034836002336 conserved gate region; other site 1034836002337 putative PBP binding loops; other site 1034836002338 ABC-ATPase subunit interface; other site 1034836002339 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034836002340 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836002341 Walker A/P-loop; other site 1034836002342 ATP binding site [chemical binding]; other site 1034836002343 Q-loop/lid; other site 1034836002344 ABC transporter signature motif; other site 1034836002345 Walker B; other site 1034836002346 D-loop; other site 1034836002347 H-loop/switch region; other site 1034836002348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836002349 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1034836002350 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836002351 Walker A/P-loop; other site 1034836002352 ATP binding site [chemical binding]; other site 1034836002353 Q-loop/lid; other site 1034836002354 ABC transporter signature motif; other site 1034836002355 Walker B; other site 1034836002356 D-loop; other site 1034836002357 H-loop/switch region; other site 1034836002358 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836002359 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1034836002360 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1034836002361 tetramer interface [polypeptide binding]; other site 1034836002362 heme binding pocket [chemical binding]; other site 1034836002363 NADPH binding site [chemical binding]; other site 1034836002364 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1034836002365 active site 1034836002366 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1034836002367 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1034836002368 Walker A/P-loop; other site 1034836002369 ATP binding site [chemical binding]; other site 1034836002370 Q-loop/lid; other site 1034836002371 ABC transporter signature motif; other site 1034836002372 Walker B; other site 1034836002373 D-loop; other site 1034836002374 H-loop/switch region; other site 1034836002375 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1034836002376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836002377 substrate binding pocket [chemical binding]; other site 1034836002378 membrane-bound complex binding site; other site 1034836002379 hinge residues; other site 1034836002380 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1034836002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836002382 dimer interface [polypeptide binding]; other site 1034836002383 conserved gate region; other site 1034836002384 putative PBP binding loops; other site 1034836002385 ABC-ATPase subunit interface; other site 1034836002386 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1034836002387 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1034836002388 active site 1034836002389 dimer interface [polypeptide binding]; other site 1034836002390 non-prolyl cis peptide bond; other site 1034836002391 insertion regions; other site 1034836002392 potential frameshift: common BLAST hit: gi|308172874|ref|YP_003919579.1| sulfur oxidoreductase 1034836002393 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1034836002394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836002395 non-specific DNA binding site [nucleotide binding]; other site 1034836002396 salt bridge; other site 1034836002397 sequence-specific DNA binding site [nucleotide binding]; other site 1034836002398 B3/4 domain; Region: B3_4; cl11458 1034836002399 iron-sulfur cluster binding protein, putative; Region: TIGR00276 1034836002400 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1034836002401 HEAT repeats; Region: HEAT_2; pfam13646 1034836002402 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1034836002403 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836002404 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1034836002405 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1034836002406 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1034836002407 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1034836002408 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1034836002409 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1034836002410 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1034836002411 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1034836002412 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836002413 Helix-turn-helix domains; Region: HTH; cl00088 1034836002414 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034836002415 carboxyltransferase (CT) interaction site; other site 1034836002416 biotinylation site [posttranslational modification]; other site 1034836002417 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1034836002418 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1034836002419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002420 putative substrate translocation pore; other site 1034836002421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002422 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836002423 Predicted transcriptional regulators [Transcription]; Region: COG1725 1034836002424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836002425 DNA-binding site [nucleotide binding]; DNA binding site 1034836002426 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034836002427 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1034836002428 Walker A/P-loop; other site 1034836002429 ATP binding site [chemical binding]; other site 1034836002430 Q-loop/lid; other site 1034836002431 ABC transporter signature motif; other site 1034836002432 Walker B; other site 1034836002433 D-loop; other site 1034836002434 H-loop/switch region; other site 1034836002435 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034836002436 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1034836002437 Walker A/P-loop; other site 1034836002438 ATP binding site [chemical binding]; other site 1034836002439 Q-loop/lid; other site 1034836002440 ABC transporter signature motif; other site 1034836002441 Walker B; other site 1034836002442 D-loop; other site 1034836002443 H-loop/switch region; other site 1034836002444 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836002445 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1034836002446 DNA-binding site [nucleotide binding]; DNA binding site 1034836002447 RNA-binding motif; other site 1034836002448 NMT1-like family; Region: NMT1_2; cl15260 1034836002449 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836002450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1034836002451 metal binding site [ion binding]; metal-binding site 1034836002452 active site 1034836002453 I-site; other site 1034836002454 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1034836002455 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1034836002456 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034836002457 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1034836002458 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1034836002459 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1034836002460 Coat F domain; Region: Coat_F; cl15836 1034836002461 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1034836002462 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1034836002463 putative active site [active] 1034836002464 putative metal binding site [ion binding]; other site 1034836002465 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034836002466 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 1034836002467 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1034836002468 active site 1034836002469 catalytic site [active] 1034836002470 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1034836002471 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034836002472 active site 1034836002473 FOG: CBS domain [General function prediction only]; Region: COG0517 1034836002474 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1034836002475 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1034836002476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836002477 motif II; other site 1034836002478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836002479 Coenzyme A binding pocket [chemical binding]; other site 1034836002480 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1034836002481 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1034836002482 putative active site [active] 1034836002483 catalytic triad [active] 1034836002484 putative dimer interface [polypeptide binding]; other site 1034836002485 aminotransferase; Validated; Region: PRK07678 1034836002486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836002487 inhibitor-cofactor binding pocket; inhibition site 1034836002488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002489 catalytic residue [active] 1034836002490 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1034836002491 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1034836002492 amphipathic channel; other site 1034836002493 Asn-Pro-Ala signature motifs; other site 1034836002494 glycerol kinase; Provisional; Region: glpK; PRK00047 1034836002495 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1034836002496 N- and C-terminal domain interface [polypeptide binding]; other site 1034836002497 active site 1034836002498 MgATP binding site [chemical binding]; other site 1034836002499 catalytic site [active] 1034836002500 metal binding site [ion binding]; metal-binding site 1034836002501 glycerol binding site [chemical binding]; other site 1034836002502 homotetramer interface [polypeptide binding]; other site 1034836002503 homodimer interface [polypeptide binding]; other site 1034836002504 FBP binding site [chemical binding]; other site 1034836002505 protein IIAGlc interface [polypeptide binding]; other site 1034836002506 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1034836002507 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1034836002508 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1034836002509 active site 1034836002510 substrate binding site [chemical binding]; other site 1034836002511 metal binding site [ion binding]; metal-binding site 1034836002512 GAF domain; Region: GAF_2; pfam13185 1034836002513 GAF domain; Region: GAF; cl15785 1034836002514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1034836002515 Histidine kinase; Region: HisKA_3; pfam07730 1034836002516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836002517 ATP binding site [chemical binding]; other site 1034836002518 Mg2+ binding site [ion binding]; other site 1034836002519 G-X-G motif; other site 1034836002520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836002521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836002522 active site 1034836002523 phosphorylation site [posttranslational modification] 1034836002524 intermolecular recognition site; other site 1034836002525 dimerization interface [polypeptide binding]; other site 1034836002526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836002527 DNA binding residues [nucleotide binding] 1034836002528 dimerization interface [polypeptide binding]; other site 1034836002529 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836002530 YhdB-like protein; Region: YhdB; pfam14148 1034836002531 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1034836002532 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002535 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002536 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1034836002537 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002538 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836002539 Helix-turn-helix domains; Region: HTH; cl00088 1034836002540 Rrf2 family protein; Region: rrf2_super; TIGR00738 1034836002541 Conserved TM helix; Region: TM_helix; pfam05552 1034836002542 Conserved TM helix; Region: TM_helix; pfam05552 1034836002543 Conserved TM helix; Region: TM_helix; pfam05552 1034836002544 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1034836002545 SpoVR like protein; Region: SpoVR; pfam04293 1034836002546 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1034836002547 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1034836002548 dimer interface [polypeptide binding]; other site 1034836002549 active site 1034836002550 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836002552 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836002553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836002554 Helix-turn-helix domains; Region: HTH; cl00088 1034836002555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836002556 dimerization interface [polypeptide binding]; other site 1034836002557 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1034836002558 dimer interface [polypeptide binding]; other site 1034836002559 Citrate synthase; Region: Citrate_synt; pfam00285 1034836002560 active site 1034836002561 citrylCoA binding site [chemical binding]; other site 1034836002562 oxalacetate/citrate binding site [chemical binding]; other site 1034836002563 coenzyme A binding site [chemical binding]; other site 1034836002564 catalytic triad [active] 1034836002565 short chain dehydrogenase; Provisional; Region: PRK06701 1034836002566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002567 NAD(P) binding site [chemical binding]; other site 1034836002568 active site 1034836002569 Spore germination protein; Region: Spore_permease; cl15802 1034836002570 amino acid transporter; Region: 2A0306; TIGR00909 1034836002571 Spore germination protein; Region: Spore_permease; cl15802 1034836002572 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1034836002573 putative substrate binding site 2 [chemical binding]; other site 1034836002574 putative substrate binding site 1 [chemical binding]; other site 1034836002575 Na binding site 1 [ion binding]; other site 1034836002576 Na2 binding site [ion binding]; other site 1034836002577 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1034836002578 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1034836002579 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1034836002580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836002581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836002582 DNA binding residues [nucleotide binding] 1034836002583 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1034836002584 putative acyl-acceptor binding pocket; other site 1034836002585 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1034836002586 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034836002587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034836002588 Transporter associated domain; Region: CorC_HlyC; cl08393 1034836002589 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836002590 aspartate aminotransferase; Provisional; Region: PRK06836 1034836002591 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836002592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002593 homodimer interface [polypeptide binding]; other site 1034836002594 catalytic residue [active] 1034836002595 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1034836002596 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1034836002597 dimer interface [polypeptide binding]; other site 1034836002598 active site 1034836002599 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1034836002600 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034836002601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034836002602 Transporter associated domain; Region: CorC_HlyC; cl08393 1034836002603 CrcB-like protein; Region: CRCB; cl09114 1034836002604 CrcB-like protein; Region: CRCB; cl09114 1034836002605 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1034836002606 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1034836002607 active site 1034836002608 catalytic site [active] 1034836002609 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1034836002610 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1034836002611 NAD-dependent deacetylase; Provisional; Region: PRK00481 1034836002612 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1034836002613 NAD+ binding site [chemical binding]; other site 1034836002614 substrate binding site [chemical binding]; other site 1034836002615 Zn binding site [ion binding]; other site 1034836002616 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1034836002617 NodB motif; other site 1034836002618 active site 1034836002619 catalytic site [active] 1034836002620 Zn binding site [ion binding]; other site 1034836002621 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1034836002622 homodimer interface [polypeptide binding]; other site 1034836002623 substrate-cofactor binding pocket; other site 1034836002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002625 catalytic residue [active] 1034836002626 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1034836002627 Helix-turn-helix domains; Region: HTH; cl00088 1034836002628 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1034836002629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1034836002630 Ligand Binding Site [chemical binding]; other site 1034836002631 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002632 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1034836002633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836002634 Walker A/P-loop; other site 1034836002635 ATP binding site [chemical binding]; other site 1034836002636 Q-loop/lid; other site 1034836002637 ABC transporter signature motif; other site 1034836002638 Walker B; other site 1034836002639 D-loop; other site 1034836002640 H-loop/switch region; other site 1034836002641 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836002642 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836002643 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1034836002644 Walker A/P-loop; other site 1034836002645 ATP binding site [chemical binding]; other site 1034836002646 Q-loop/lid; other site 1034836002647 ABC transporter signature motif; other site 1034836002648 Walker B; other site 1034836002649 D-loop; other site 1034836002650 H-loop/switch region; other site 1034836002651 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1034836002652 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034836002653 NAD binding site [chemical binding]; other site 1034836002654 substrate binding site [chemical binding]; other site 1034836002655 putative active site [active] 1034836002656 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1034836002657 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836002658 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836002659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1034836002660 Protein of unknown function (DUF964); Region: DUF964; cl01483 1034836002661 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836002662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836002663 active site 1034836002664 motif I; other site 1034836002665 motif II; other site 1034836002666 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836002667 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1034836002668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836002669 FeS/SAM binding site; other site 1034836002670 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1034836002671 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1034836002672 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1034836002673 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1034836002674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836002675 enoyl-CoA hydratase; Provisional; Region: PRK07659 1034836002676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836002677 substrate binding site [chemical binding]; other site 1034836002678 oxyanion hole (OAH) forming residues; other site 1034836002679 trimer interface [polypeptide binding]; other site 1034836002680 YhzD-like protein; Region: YhzD; pfam14120 1034836002681 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1034836002682 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 1034836002683 Walker A/P-loop; other site 1034836002684 ATP binding site [chemical binding]; other site 1034836002685 Q-loop/lid; other site 1034836002686 ABC transporter signature motif; other site 1034836002687 Walker B; other site 1034836002688 D-loop; other site 1034836002689 H-loop/switch region; other site 1034836002690 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1034836002691 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1034836002692 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1034836002693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034836002694 active site 1034836002695 metal binding site [ion binding]; metal-binding site 1034836002696 DNA binding site [nucleotide binding] 1034836002697 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1034836002698 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1034836002699 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 1034836002700 generic binding surface II; other site 1034836002701 generic binding surface I; other site 1034836002702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034836002703 Zn2+ binding site [ion binding]; other site 1034836002704 Mg2+ binding site [ion binding]; other site 1034836002705 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1034836002706 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1034836002707 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1034836002708 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1034836002709 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1034836002710 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1034836002711 transcriptional regulator Hpr; Provisional; Region: PRK13777 1034836002712 Helix-turn-helix domains; Region: HTH; cl00088 1034836002713 YtxH-like protein; Region: YtxH; cl02079 1034836002714 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1034836002715 homodimer interface [polypeptide binding]; other site 1034836002716 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1034836002717 substrate-cofactor binding pocket; other site 1034836002718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002719 catalytic residue [active] 1034836002720 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1034836002721 HIT family signature motif; other site 1034836002722 catalytic residue [active] 1034836002723 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034836002724 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1034836002725 Walker A/P-loop; other site 1034836002726 ATP binding site [chemical binding]; other site 1034836002727 Q-loop/lid; other site 1034836002728 ABC transporter signature motif; other site 1034836002729 Walker B; other site 1034836002730 D-loop; other site 1034836002731 H-loop/switch region; other site 1034836002732 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1034836002733 EcsC protein family; Region: EcsC; pfam12787 1034836002734 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034836002735 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1034836002736 metal binding site [ion binding]; metal-binding site 1034836002737 dimer interface [polypeptide binding]; other site 1034836002738 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836002739 Transglycosylase; Region: Transgly; cl07896 1034836002740 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1034836002741 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836002742 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1034836002743 substrate binding site [chemical binding]; other site 1034836002744 active site 1034836002745 ferrochelatase; Provisional; Region: PRK12435 1034836002746 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1034836002747 C-terminal domain interface [polypeptide binding]; other site 1034836002748 active site 1034836002749 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1034836002750 active site 1034836002751 N-terminal domain interface [polypeptide binding]; other site 1034836002752 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1034836002753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836002755 Helix-turn-helix domains; Region: HTH; cl00088 1034836002756 Predicted membrane protein [Function unknown]; Region: COG1511 1034836002757 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1034836002758 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836002759 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1034836002760 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1034836002761 dimer interface [polypeptide binding]; other site 1034836002762 active site 1034836002763 CoA binding pocket [chemical binding]; other site 1034836002764 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1034836002765 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1034836002766 putative oligomer interface [polypeptide binding]; other site 1034836002767 putative active site [active] 1034836002768 metal binding site [ion binding]; metal-binding site 1034836002769 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1034836002770 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1034836002771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836002772 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1034836002773 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1034836002774 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1034836002775 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1034836002776 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034836002777 NAD(P) binding site [chemical binding]; other site 1034836002778 putative active site [active] 1034836002779 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1034836002780 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836002781 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836002782 Peptidase family M48; Region: Peptidase_M48; cl12018 1034836002783 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1034836002784 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1034836002785 active site 1034836002786 catalytic residues [active] 1034836002787 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1034836002788 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1034836002789 siderophore binding site; other site 1034836002790 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034836002791 catalytic core [active] 1034836002792 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1034836002793 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1034836002794 dimer interface [polypeptide binding]; other site 1034836002795 active site 1034836002796 acyl-CoA synthetase; Validated; Region: PRK07638 1034836002797 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836002798 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836002799 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1034836002800 heme-binding site [chemical binding]; other site 1034836002801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836002802 dimer interface [polypeptide binding]; other site 1034836002803 putative CheW interface [polypeptide binding]; other site 1034836002804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002805 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1034836002806 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1034836002807 [2Fe-2S] cluster binding site [ion binding]; other site 1034836002808 short chain dehydrogenase; Provisional; Region: PRK06701 1034836002809 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1034836002810 NAD binding site [chemical binding]; other site 1034836002811 metal binding site [ion binding]; metal-binding site 1034836002812 active site 1034836002813 IDEAL domain; Region: IDEAL; cl07452 1034836002814 ComK protein; Region: ComK; cl11560 1034836002815 Protein of unknown function (DUF419); Region: DUF419; cl15265 1034836002816 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836002817 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1034836002818 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1034836002819 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1034836002820 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1034836002821 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1034836002822 Na binding site [ion binding]; other site 1034836002823 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1034836002824 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836002825 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1034836002826 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1034836002827 Catalytic site [active] 1034836002828 hypothetical protein; Provisional; Region: PRK08244 1034836002829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836002831 Helix-turn-helix domains; Region: HTH; cl00088 1034836002832 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1034836002833 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1034836002834 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1034836002835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836002836 putative substrate translocation pore; other site 1034836002837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836002838 Helix-turn-helix domains; Region: HTH; cl00088 1034836002839 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1034836002840 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1034836002841 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1034836002842 dinuclear metal binding motif [ion binding]; other site 1034836002843 Protein of unknown function (DUF421); Region: DUF421; cl00990 1034836002844 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1034836002845 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1034836002846 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1034836002847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836002848 Family description; Region: UvrD_C_2; cl15862 1034836002849 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1034836002850 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1034836002851 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1034836002852 active site 1034836002853 metal binding site [ion binding]; metal-binding site 1034836002854 DNA binding site [nucleotide binding] 1034836002855 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1034836002856 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1034836002857 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1034836002858 Walker A/P-loop; other site 1034836002859 ATP binding site [chemical binding]; other site 1034836002860 Q-loop/lid; other site 1034836002861 ABC transporter signature motif; other site 1034836002862 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1034836002863 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1034836002864 ABC transporter signature motif; other site 1034836002865 Walker B; other site 1034836002866 D-loop; other site 1034836002867 H-loop/switch region; other site 1034836002868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1034836002869 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836002870 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1034836002871 Spore germination protein GerPC; Region: GerPC; pfam10737 1034836002872 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1034836002873 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836002874 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1034836002875 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1034836002876 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1034836002877 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 1034836002878 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1034836002879 active site 1034836002880 catalytic triad [active] 1034836002881 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1034836002882 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1034836002883 active site 1034836002884 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1034836002885 dimer interface [polypeptide binding]; other site 1034836002886 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1034836002887 Ligand Binding Site [chemical binding]; other site 1034836002888 Molecular Tunnel; other site 1034836002889 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1034836002890 substrate binding pocket [chemical binding]; other site 1034836002891 substrate-Mg2+ binding site; other site 1034836002892 aspartate-rich region 1; other site 1034836002893 aspartate-rich region 2; other site 1034836002894 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1034836002895 MatE; Region: MatE; cl10513 1034836002896 MatE; Region: MatE; cl10513 1034836002897 Cupin domain; Region: Cupin_2; cl09118 1034836002898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836002899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034836002900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836002901 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836002902 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836002903 DNA binding site [nucleotide binding] 1034836002904 domain linker motif; other site 1034836002905 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1034836002906 dimerization interface [polypeptide binding]; other site 1034836002907 ligand binding site [chemical binding]; other site 1034836002908 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1034836002909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836002910 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1034836002911 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836002912 LysE type translocator; Region: LysE; cl00565 1034836002913 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836002914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836002915 DNA-binding site [nucleotide binding]; DNA binding site 1034836002916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836002917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836002918 homodimer interface [polypeptide binding]; other site 1034836002919 catalytic residue [active] 1034836002920 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1034836002921 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836002922 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1034836002923 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1034836002924 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1034836002925 FAD binding site [chemical binding]; other site 1034836002926 Protein of unknown function (DUF520); Region: DUF520; cl00723 1034836002927 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1034836002928 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1034836002929 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1034836002930 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1034836002931 ligand binding site [chemical binding]; other site 1034836002932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836002933 dimerization interface [polypeptide binding]; other site 1034836002934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1034836002935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836002936 dimer interface [polypeptide binding]; other site 1034836002937 putative CheW interface [polypeptide binding]; other site 1034836002938 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836002939 Cytochrome P450; Region: p450; pfam00067 1034836002940 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1034836002941 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836002942 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836002943 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836002944 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836002945 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1034836002946 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1034836002947 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836002948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836002949 motif II; other site 1034836002950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836002951 esterase; Provisional; Region: PRK10566 1034836002952 Domain of unknown function DUF59; Region: DUF59; cl00941 1034836002953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836002954 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034836002955 active site 1034836002956 metal binding site [ion binding]; metal-binding site 1034836002957 FAD binding domain; Region: FAD_binding_4; pfam01565 1034836002958 Sulfatase; Region: Sulfatase; cl10460 1034836002959 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1034836002960 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1034836002961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836002962 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1034836002963 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1034836002964 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1034836002965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836002966 ATP binding site [chemical binding]; other site 1034836002967 Mg2+ binding site [ion binding]; other site 1034836002968 G-X-G motif; other site 1034836002969 sporulation sigma factor SigF; Validated; Region: PRK05572 1034836002970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836002971 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034836002972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836002973 DNA binding residues [nucleotide binding] 1034836002974 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1034836002975 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1034836002976 SpoVA protein; Region: SpoVA; cl04298 1034836002977 stage V sporulation protein AD; Validated; Region: PRK08304 1034836002978 stage V sporulation protein AD; Provisional; Region: PRK12404 1034836002979 SpoVA protein; Region: SpoVA; cl04298 1034836002980 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1034836002981 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1034836002982 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1034836002983 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1034836002984 active site 1034836002985 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034836002986 substrate binding site [chemical binding]; other site 1034836002987 catalytic residues [active] 1034836002988 dimer interface [polypeptide binding]; other site 1034836002989 Predicted secreted protein [Function unknown]; Region: COG4086 1034836002990 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1034836002991 active site 1034836002992 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1034836002993 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1034836002994 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1034836002995 Catalytic site [active] 1034836002996 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1034836002997 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1034836002998 catalytic motif [active] 1034836002999 Zn binding site [ion binding]; other site 1034836003000 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1034836003001 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1034836003002 Lumazine binding domain; Region: Lum_binding; pfam00677 1034836003003 Lumazine binding domain; Region: Lum_binding; pfam00677 1034836003004 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1034836003005 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1034836003006 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1034836003007 dimerization interface [polypeptide binding]; other site 1034836003008 active site 1034836003009 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1034836003010 homopentamer interface [polypeptide binding]; other site 1034836003011 active site 1034836003012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836003013 Coenzyme A binding pocket [chemical binding]; other site 1034836003014 Domain of unknown function (DUF309); Region: DUF309; cl00667 1034836003015 ScpA/B protein; Region: ScpA_ScpB; cl00598 1034836003016 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1034836003017 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1034836003018 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1034836003019 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836003020 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1034836003021 Nucleoside recognition; Region: Gate; cl00486 1034836003022 Nucleoside recognition; Region: Gate; cl00486 1034836003023 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1034836003024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836003025 RNA binding surface [nucleotide binding]; other site 1034836003026 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1034836003027 active site 1034836003028 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1034836003029 catalytic residues [active] 1034836003030 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1034836003031 ResB-like family; Region: ResB; pfam05140 1034836003032 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1034836003033 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1034836003034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836003035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836003036 active site 1034836003037 phosphorylation site [posttranslational modification] 1034836003038 intermolecular recognition site; other site 1034836003039 dimerization interface [polypeptide binding]; other site 1034836003040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836003041 DNA binding site [nucleotide binding] 1034836003042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1034836003043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836003044 dimerization interface [polypeptide binding]; other site 1034836003045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836003046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836003047 dimer interface [polypeptide binding]; other site 1034836003048 phosphorylation site [posttranslational modification] 1034836003049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836003050 ATP binding site [chemical binding]; other site 1034836003051 Mg2+ binding site [ion binding]; other site 1034836003052 G-X-G motif; other site 1034836003053 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1034836003054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836003055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836003056 DNA binding residues [nucleotide binding] 1034836003057 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1034836003058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003059 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1034836003060 putative L-serine binding site [chemical binding]; other site 1034836003061 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836003062 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1034836003063 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1034836003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1034836003065 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1034836003066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836003067 ATP binding site [chemical binding]; other site 1034836003068 putative Mg++ binding site [ion binding]; other site 1034836003069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836003070 nucleotide binding region [chemical binding]; other site 1034836003071 ATP-binding site [chemical binding]; other site 1034836003072 CAAX protease self-immunity; Region: Abi; cl00558 1034836003073 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003074 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1034836003075 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1034836003076 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1034836003077 putative active site [active] 1034836003078 putative metal binding site [ion binding]; other site 1034836003079 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1034836003080 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1034836003081 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1034836003082 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1034836003083 NAD(P) binding site [chemical binding]; other site 1034836003084 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1034836003085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836003087 Protease prsW family; Region: PrsW-protease; cl15823 1034836003088 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1034836003089 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836003090 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1034836003091 germination protein YpeB; Region: spore_YpeB; TIGR02889 1034836003092 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1034836003093 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1034836003094 PilZ domain; Region: PilZ; cl01260 1034836003095 cytidylate kinase; Provisional; Region: cmk; PRK00023 1034836003096 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1034836003097 CMP-binding site; other site 1034836003098 The sites determining sugar specificity; other site 1034836003099 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1034836003100 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1034836003101 RNA binding site [nucleotide binding]; other site 1034836003102 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1034836003103 RNA binding site [nucleotide binding]; other site 1034836003104 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 1034836003105 RNA binding site [nucleotide binding]; other site 1034836003106 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1034836003107 RNA binding site [nucleotide binding]; other site 1034836003108 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1034836003109 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1034836003110 homotetramer interface [polypeptide binding]; other site 1034836003111 FMN binding site [chemical binding]; other site 1034836003112 homodimer contacts [polypeptide binding]; other site 1034836003113 putative active site [active] 1034836003114 putative substrate binding site [chemical binding]; other site 1034836003115 YpzI-like protein; Region: YpzI; pfam14140 1034836003116 GTP-binding protein Der; Reviewed; Region: PRK00093 1034836003117 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1034836003118 G1 box; other site 1034836003119 GTP/Mg2+ binding site [chemical binding]; other site 1034836003120 Switch I region; other site 1034836003121 G2 box; other site 1034836003122 Switch II region; other site 1034836003123 G3 box; other site 1034836003124 G4 box; other site 1034836003125 G5 box; other site 1034836003126 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1034836003127 G1 box; other site 1034836003128 GTP/Mg2+ binding site [chemical binding]; other site 1034836003129 Switch I region; other site 1034836003130 G2 box; other site 1034836003131 G3 box; other site 1034836003132 Switch II region; other site 1034836003133 G4 box; other site 1034836003134 G5 box; other site 1034836003135 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1034836003136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003137 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1034836003138 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1034836003139 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 1034836003140 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1034836003141 IHF dimer interface [polypeptide binding]; other site 1034836003142 IHF - DNA interface [nucleotide binding]; other site 1034836003143 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1034836003144 homodecamer interface [polypeptide binding]; other site 1034836003145 GTP cyclohydrolase I; Provisional; Region: PLN03044 1034836003146 active site 1034836003147 putative catalytic site residues [active] 1034836003148 zinc binding site [ion binding]; other site 1034836003149 GTP-CH-I/GFRP interaction surface; other site 1034836003150 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 1034836003151 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1034836003152 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1034836003153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836003154 S-adenosylmethionine binding site [chemical binding]; other site 1034836003155 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1034836003156 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1034836003157 substrate binding pocket [chemical binding]; other site 1034836003158 chain length determination region; other site 1034836003159 substrate-Mg2+ binding site; other site 1034836003160 catalytic residues [active] 1034836003161 aspartate-rich region 1; other site 1034836003162 active site lid residues [active] 1034836003163 aspartate-rich region 2; other site 1034836003164 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1034836003165 active site 1034836003166 multimer interface [polypeptide binding]; other site 1034836003167 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1034836003168 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1034836003169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836003170 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1034836003171 Tetramer interface [polypeptide binding]; other site 1034836003172 active site 1034836003173 FMN-binding site [chemical binding]; other site 1034836003174 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1034836003175 active site 1034836003176 dimer interface [polypeptide binding]; other site 1034836003177 metal binding site [ion binding]; metal-binding site 1034836003178 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1034836003179 homotrimer interaction site [polypeptide binding]; other site 1034836003180 active site 1034836003181 anthranilate synthase component I; Provisional; Region: PRK13569 1034836003182 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1034836003183 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1034836003184 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1034836003185 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1034836003186 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1034836003187 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1034836003188 active site 1034836003189 ribulose/triose binding site [chemical binding]; other site 1034836003190 phosphate binding site [ion binding]; other site 1034836003191 substrate (anthranilate) binding pocket [chemical binding]; other site 1034836003192 product (indole) binding pocket [chemical binding]; other site 1034836003193 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1034836003194 active site 1034836003195 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1034836003196 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1034836003197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003198 catalytic residue [active] 1034836003199 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1034836003200 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1034836003201 substrate binding site [chemical binding]; other site 1034836003202 active site 1034836003203 catalytic residues [active] 1034836003204 heterodimer interface [polypeptide binding]; other site 1034836003205 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1034836003206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836003207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003208 homodimer interface [polypeptide binding]; other site 1034836003209 catalytic residue [active] 1034836003210 prephenate dehydrogenase; Validated; Region: PRK06545 1034836003211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003212 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1034836003213 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1034836003214 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1034836003215 hinge; other site 1034836003216 active site 1034836003217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836003218 TPR motif; other site 1034836003219 binding surface 1034836003220 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1034836003221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836003222 binding surface 1034836003223 TPR motif; other site 1034836003224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836003225 binding surface 1034836003226 TPR motif; other site 1034836003227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836003228 binding surface 1034836003229 TPR motif; other site 1034836003230 hypothetical protein; Provisional; Region: PRK03636 1034836003231 UPF0302 domain; Region: UPF0302; pfam08864 1034836003232 IDEAL domain; Region: IDEAL; cl07452 1034836003233 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1034836003234 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1034836003235 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1034836003236 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1034836003237 iron-sulfur cluster [ion binding]; other site 1034836003238 [2Fe-2S] cluster binding site [ion binding]; other site 1034836003239 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1034836003240 interchain domain interface [polypeptide binding]; other site 1034836003241 intrachain domain interface; other site 1034836003242 heme bH binding site [chemical binding]; other site 1034836003243 Qi binding site; other site 1034836003244 heme bL binding site [chemical binding]; other site 1034836003245 Qo binding site; other site 1034836003246 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1034836003247 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1034836003248 Cytochrome c; Region: Cytochrom_C; cl11414 1034836003249 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1034836003250 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1034836003251 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1034836003252 Cupin domain; Region: Cupin_2; cl09118 1034836003253 Cupin domain; Region: Cupin_2; cl09118 1034836003254 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836003255 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836003256 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836003257 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836003258 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1034836003259 homodimer interface [polypeptide binding]; other site 1034836003260 metal binding site [ion binding]; metal-binding site 1034836003261 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1034836003262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003263 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1034836003264 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1034836003265 active site 1034836003266 dimer interfaces [polypeptide binding]; other site 1034836003267 catalytic residues [active] 1034836003268 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1034836003269 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1034836003270 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1034836003271 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1034836003272 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1034836003273 active site 1034836003274 NTP binding site [chemical binding]; other site 1034836003275 metal binding triad [ion binding]; metal-binding site 1034836003276 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1034836003277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1034836003278 Helix-turn-helix domains; Region: HTH; cl00088 1034836003279 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1034836003280 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1034836003281 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1034836003282 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1034836003283 oligomerization interface [polypeptide binding]; other site 1034836003284 active site 1034836003285 metal binding site [ion binding]; metal-binding site 1034836003286 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1034836003287 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1034836003288 active site 1034836003289 ATP-binding site [chemical binding]; other site 1034836003290 pantoate-binding site; other site 1034836003291 HXXH motif; other site 1034836003292 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1034836003293 tetramerization interface [polypeptide binding]; other site 1034836003294 active site 1034836003295 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1034836003296 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1034836003297 active site 1034836003298 catalytic site [active] 1034836003299 substrate binding site [chemical binding]; other site 1034836003300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003301 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1034836003302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1034836003303 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836003304 aspartate aminotransferase; Provisional; Region: PRK05764 1034836003305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836003306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003307 homodimer interface [polypeptide binding]; other site 1034836003308 catalytic residue [active] 1034836003309 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1034836003310 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1034836003311 putative dimer interface [polypeptide binding]; other site 1034836003312 putative anticodon binding site; other site 1034836003313 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1034836003314 homodimer interface [polypeptide binding]; other site 1034836003315 motif 1; other site 1034836003316 motif 2; other site 1034836003317 active site 1034836003318 motif 3; other site 1034836003319 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1034836003320 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1034836003321 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1034836003322 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034836003323 minor groove reading motif; other site 1034836003324 helix-hairpin-helix signature motif; other site 1034836003325 substrate binding pocket [chemical binding]; other site 1034836003326 active site 1034836003327 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1034836003328 Transglycosylase; Region: Transgly; cl07896 1034836003329 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1034836003330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836003331 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1034836003332 Recombination protein U; Region: RecU; cl01314 1034836003333 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1034836003334 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1034836003335 YppF-like protein; Region: YppF; pfam14178 1034836003336 YppG-like protein; Region: YppG; pfam14179 1034836003337 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1034836003338 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1034836003339 HPr interaction site; other site 1034836003340 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034836003341 active site 1034836003342 phosphorylation site [posttranslational modification] 1034836003343 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1034836003344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836003345 ATP binding site [chemical binding]; other site 1034836003346 putative Mg++ binding site [ion binding]; other site 1034836003347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836003348 nucleotide binding region [chemical binding]; other site 1034836003349 ATP-binding site [chemical binding]; other site 1034836003350 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1034836003351 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1034836003352 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1034836003353 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1034836003354 cell division protein GpsB; Provisional; Region: PRK14127 1034836003355 DivIVA domain; Region: DivI1A_domain; TIGR03544 1034836003356 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1034836003357 THUMP domain; Region: THUMP; cl12076 1034836003358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836003359 YpzG-like protein; Region: YpzG; pfam14139 1034836003360 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1034836003361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003363 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1034836003364 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1034836003365 active site 1034836003366 Zn binding site [ion binding]; other site 1034836003367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836003368 active site 1034836003369 xanthine permease; Region: pbuX; TIGR03173 1034836003370 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1034836003371 catalytic residues [active] 1034836003372 catalytic nucleophile [active] 1034836003373 Recombinase; Region: Recombinase; pfam07508 1034836003374 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1034836003375 Staphylococcal nuclease homologues; Region: SNc; smart00318 1034836003376 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1034836003377 Catalytic site; other site 1034836003378 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1034836003379 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836003380 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836003381 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1034836003382 active site 1034836003383 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836003384 potential frameshift: common BLAST hit: gi|154687346|ref|YP_001422507.1| YunB 1034836003385 YolD-like protein; Region: YolD; pfam08863 1034836003386 DNA polymerase IV; Reviewed; Region: PRK03103 1034836003387 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1034836003388 active site 1034836003389 DNA binding site [nucleotide binding] 1034836003390 potential frameshift: common BLAST hit: gi|323651054|ref|YP_004243697.1| response regulator aspartate phosphatase 1034836003391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836003392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836003393 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836003394 amidase catalytic site [active] 1034836003395 Zn binding residues [ion binding]; other site 1034836003396 substrate binding site [chemical binding]; other site 1034836003397 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836003398 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1034836003399 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836003400 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1034836003401 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1034836003402 Phage-related protein [Function unknown]; Region: COG4722; cl15832 1034836003403 Phage tail protein; Region: Sipho_tail; pfam05709 1034836003404 potential frameshift: common BLAST hit: gi|221310044|ref|ZP_03591891.1| hypothetical protein Bsubs1_11756 1034836003405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1034836003406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1034836003407 active site 1034836003408 ATP binding site [chemical binding]; other site 1034836003409 substrate binding site [chemical binding]; other site 1034836003410 activation loop (A-loop); other site 1034836003411 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1034836003412 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1034836003413 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1034836003414 active site 1034836003415 catalytic residues [active] 1034836003416 DNA binding site [nucleotide binding] 1034836003417 Int/Topo IB signature motif; other site 1034836003418 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1034836003419 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1034836003420 active site 1034836003421 catalytic site [active] 1034836003422 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1034836003423 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1034836003424 ACT domain-containing protein [General function prediction only]; Region: COG1707 1034836003425 replicative DNA helicase; Validated; Region: PRK07773 1034836003426 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1034836003427 protein-splicing catalytic site; other site 1034836003428 thioester formation/cholesterol transfer; other site 1034836003429 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 1034836003430 Terminase-like family; Region: Terminase_6; pfam03237 1034836003431 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1034836003432 IHF - DNA interface [nucleotide binding]; other site 1034836003433 IHF dimer interface [polypeptide binding]; other site 1034836003434 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1034836003435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836003436 non-specific DNA binding site [nucleotide binding]; other site 1034836003437 salt bridge; other site 1034836003438 sequence-specific DNA binding site [nucleotide binding]; other site 1034836003439 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1034836003440 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1034836003441 nucleotide binding site [chemical binding]; other site 1034836003442 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1034836003443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003444 Family description; Region: UvrD_C_2; cl15862 1034836003445 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1034836003446 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1034836003447 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1034836003448 OpgC protein; Region: OpgC_C; cl00792 1034836003449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836003450 HIRAN domain; Region: HIRAN; cl07418 1034836003451 UPF0489 domain; Region: UPF0489; pfam12640 1034836003452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836003453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034836003454 active site 1034836003455 DNA binding site [nucleotide binding] 1034836003456 Int/Topo IB signature motif; other site 1034836003457 DNA-sulfur modification-associated; Region: DndB; cl14002 1034836003458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836003459 Hypothetical protein Yopt; Region: Yopt; pfam09467 1034836003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836003461 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1034836003462 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1034836003463 active site 1034836003464 DNA binding site [nucleotide binding] 1034836003465 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1034836003466 YopX protein; Region: YopX; cl09859 1034836003467 Protein of unknown function (DUF867); Region: DUF867; cl01713 1034836003468 Right handed beta helix region; Region: Beta_helix; pfam13229 1034836003469 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1034836003470 Right handed beta helix region; Region: Beta_helix; pfam13229 1034836003471 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1034836003472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034836003473 active site 1034836003474 metal binding site [ion binding]; metal-binding site 1034836003475 AAA domain; Region: AAA_24; pfam13479 1034836003476 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1034836003477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003478 Walker A motif; other site 1034836003479 ATP binding site [chemical binding]; other site 1034836003480 Phage terminase large subunit; Region: Terminase_3; cl12054 1034836003481 hypothetical protein; Provisional; Region: PRK08624 1034836003482 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1034836003483 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1034836003484 active site 1034836003485 metal binding site [ion binding]; metal-binding site 1034836003486 interdomain interaction site; other site 1034836003487 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1034836003488 DHH family; Region: DHH; pfam01368 1034836003489 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1034836003490 active site 1034836003491 substrate binding site [chemical binding]; other site 1034836003492 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1034836003493 active site 1034836003494 DNA binding site [nucleotide binding] 1034836003495 catalytic site [active] 1034836003496 3D domain; Region: 3D; cl01439 1034836003497 YorP protein; Region: YorP; pfam09629 1034836003498 ribulose-bisphosphate carboxylase small chain; Region: PLN02289 1034836003499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003500 AAA domain; Region: AAA_18; pfam13238 1034836003501 active site 1034836003502 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836003503 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1034836003504 cofactor binding site; other site 1034836003505 DNA binding site [nucleotide binding] 1034836003506 substrate interaction site [chemical binding]; other site 1034836003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836003508 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 1034836003509 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1034836003510 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1034836003511 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1034836003512 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1034836003513 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1034836003514 dimer interface [polypeptide binding]; other site 1034836003515 putative radical transfer pathway; other site 1034836003516 diiron center [ion binding]; other site 1034836003517 tyrosyl radical; other site 1034836003518 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 1034836003519 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1034836003520 dimer interface [polypeptide binding]; other site 1034836003521 putative active site [active] 1034836003522 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1034836003523 trimer interface [polypeptide binding]; other site 1034836003524 active site 1034836003525 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1034836003526 dimerization interface [polypeptide binding]; other site 1034836003527 active site 1034836003528 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1034836003529 folate binding site [chemical binding]; other site 1034836003530 NADP+ binding site [chemical binding]; other site 1034836003531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836003532 Recombination protein U; Region: RecU; cl01314 1034836003533 xanthine permease; Region: pbuX; TIGR03173 1034836003534 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1034836003535 DNA binding site [nucleotide binding] 1034836003536 active site 1034836003537 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1034836003538 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1034836003539 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1034836003540 malonyl-CoA binding site [chemical binding]; other site 1034836003541 dimer interface [polypeptide binding]; other site 1034836003542 active site 1034836003543 product binding site; other site 1034836003544 Phospholipid methyltransferase; Region: PEMT; cl00763 1034836003545 GTP-binding protein Der; Reviewed; Region: PRK00093 1034836003546 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1034836003547 Dynamin family; Region: Dynamin_N; pfam00350 1034836003548 G1 box; other site 1034836003549 GTP/Mg2+ binding site [chemical binding]; other site 1034836003550 G2 box; other site 1034836003551 Switch I region; other site 1034836003552 G3 box; other site 1034836003553 Switch II region; other site 1034836003554 G4 box; other site 1034836003555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003556 G1 box; other site 1034836003557 GTP/Mg2+ binding site [chemical binding]; other site 1034836003558 Dynamin family; Region: Dynamin_N; pfam00350 1034836003559 G2 box; other site 1034836003560 Switch I region; other site 1034836003561 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1034836003562 G3 box; other site 1034836003563 Switch II region; other site 1034836003564 GTP/Mg2+ binding site [chemical binding]; other site 1034836003565 G4 box; other site 1034836003566 G5 box; other site 1034836003567 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1034836003568 5'-3' exonuclease; Region: 53EXOc; smart00475 1034836003569 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1034836003570 active site 1034836003571 metal binding site 1 [ion binding]; metal-binding site 1034836003572 putative 5' ssDNA interaction site; other site 1034836003573 metal binding site 3; metal-binding site 1034836003574 metal binding site 2 [ion binding]; metal-binding site 1034836003575 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1034836003576 putative DNA binding site [nucleotide binding]; other site 1034836003577 putative metal binding site [ion binding]; other site 1034836003578 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1034836003579 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1034836003580 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034836003581 active site 1034836003582 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1034836003583 hypothetical protein; Validated; Region: PRK07708 1034836003584 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1034836003585 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034836003586 active site 1034836003587 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1034836003588 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1034836003589 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1034836003590 DNA-binding site [nucleotide binding]; DNA binding site 1034836003591 RNA-binding motif; other site 1034836003592 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1034836003593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034836003594 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1034836003595 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1034836003596 proposed active site lysine [active] 1034836003597 conserved cys residue [active] 1034836003598 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1034836003599 catalytic residues [active] 1034836003600 dimer interface [polypeptide binding]; other site 1034836003601 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1034836003602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1034836003603 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1034836003604 Virulence factor; Region: Virulence_fact; pfam13769 1034836003605 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1034836003606 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1034836003607 Dehydratase family; Region: ILVD_EDD; cl00340 1034836003608 Disulphide isomerase; Region: Disulph_isomer; cl05813 1034836003609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836003610 YpjP-like protein; Region: YpjP; pfam14005 1034836003611 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1034836003612 dimerization interface [polypeptide binding]; other site 1034836003613 active site 1034836003614 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1034836003615 folate binding site [chemical binding]; other site 1034836003616 NADP+ binding site [chemical binding]; other site 1034836003617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1034836003618 putative acyl-acceptor binding pocket; other site 1034836003619 Haemolysin-III related; Region: HlyIII; cl03831 1034836003620 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1034836003621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836003622 Walker A motif; other site 1034836003623 ATP binding site [chemical binding]; other site 1034836003624 Walker B motif; other site 1034836003625 arginine finger; other site 1034836003626 threonine dehydratase; Validated; Region: PRK08639 1034836003627 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1034836003628 tetramer interface [polypeptide binding]; other site 1034836003629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003630 catalytic residue [active] 1034836003631 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1034836003632 putative Ile/Val binding site [chemical binding]; other site 1034836003633 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1034836003634 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1034836003635 Cu(I) binding site [ion binding]; other site 1034836003636 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1034836003637 active site 1034836003638 catalytic triad [active] 1034836003639 oxyanion hole [active] 1034836003640 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1034836003641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836003642 Helix-turn-helix domains; Region: HTH; cl00088 1034836003643 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1034836003644 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1034836003645 SelR domain; Region: SelR; pfam01641 1034836003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003647 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1034836003648 catalytic residues [active] 1034836003649 catalytic nucleophile [active] 1034836003650 Recombinase; Region: Recombinase; pfam07508 1034836003651 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1034836003652 Regulatory protein YrvL; Region: YrvL; pfam14184 1034836003653 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1034836003654 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1034836003655 putative active site [active] 1034836003656 putative substrate binding site [chemical binding]; other site 1034836003657 putative FMN binding site [chemical binding]; other site 1034836003658 putative catalytic residues [active] 1034836003659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003660 NAD(P) binding site [chemical binding]; other site 1034836003661 active site 1034836003662 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1034836003663 Phytase; Region: Phytase; pfam02333 1034836003664 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1034836003665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034836003666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836003667 active site 1034836003668 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1034836003669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836003670 Coenzyme A binding pocket [chemical binding]; other site 1034836003671 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1034836003672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836003673 hypothetical protein; Provisional; Region: PRK06917 1034836003674 inhibitor-cofactor binding pocket; inhibition site 1034836003675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003676 catalytic residue [active] 1034836003677 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836003678 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836003679 acetylornithine deacetylase; Validated; Region: PRK06915 1034836003680 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1034836003681 metal binding site [ion binding]; metal-binding site 1034836003682 dimer interface [polypeptide binding]; other site 1034836003683 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1034836003684 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836003685 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1034836003686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836003687 FeS/SAM binding site; other site 1034836003688 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1034836003689 YokU-like protein; Region: YokU; cl15819 1034836003690 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1034836003691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836003692 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1034836003693 YozD-like protein; Region: YozD; pfam14162 1034836003694 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1034836003695 active site 1034836003696 YodL-like; Region: YodL; pfam14191 1034836003697 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1034836003698 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1034836003699 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1034836003700 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034836003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836003702 S-adenosylmethionine binding site [chemical binding]; other site 1034836003703 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1034836003704 C-terminal peptidase (prc); Region: prc; TIGR00225 1034836003705 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1034836003706 protein binding site [polypeptide binding]; other site 1034836003707 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1034836003708 Catalytic dyad [active] 1034836003709 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836003710 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034836003711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836003712 DNA-binding site [nucleotide binding]; DNA binding site 1034836003713 UTRA domain; Region: UTRA; cl01230 1034836003714 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034836003715 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1034836003716 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1034836003717 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1034836003718 Na binding site [ion binding]; other site 1034836003719 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1034836003720 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1034836003721 Zn binding site [ion binding]; other site 1034836003722 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1034836003723 Zn binding site [ion binding]; other site 1034836003724 Predicted esterase [General function prediction only]; Region: COG0400 1034836003725 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1034836003726 dimer interface [polypeptide binding]; other site 1034836003727 FMN binding site [chemical binding]; other site 1034836003728 Helix-turn-helix domains; Region: HTH; cl00088 1034836003729 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1034836003730 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1034836003731 rarD protein; Region: rarD; TIGR00688 1034836003732 EamA-like transporter family; Region: EamA; cl01037 1034836003733 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1034836003734 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1034836003735 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836003736 multidrug efflux protein; Reviewed; Region: PRK01766 1034836003737 MatE; Region: MatE; cl10513 1034836003738 MatE; Region: MatE; cl10513 1034836003739 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1034836003740 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1034836003741 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1034836003742 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1034836003743 active site 1034836003744 TDP-binding site; other site 1034836003745 acceptor substrate-binding pocket; other site 1034836003746 homodimer interface [polypeptide binding]; other site 1034836003747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003748 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034836003749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003750 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034836003751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003752 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003753 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836003754 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1034836003755 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1034836003756 E-class dimer interface [polypeptide binding]; other site 1034836003757 P-class dimer interface [polypeptide binding]; other site 1034836003758 active site 1034836003759 Cu2+ binding site [ion binding]; other site 1034836003760 Zn2+ binding site [ion binding]; other site 1034836003761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836003762 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1034836003763 Walker A motif; other site 1034836003764 ATP binding site [chemical binding]; other site 1034836003765 Walker B motif; other site 1034836003766 arginine finger; other site 1034836003767 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1034836003768 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1034836003769 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1034836003770 metal ion-dependent adhesion site (MIDAS); other site 1034836003771 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1034836003772 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1034836003773 TPP-binding site [chemical binding]; other site 1034836003774 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1034836003775 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1034836003776 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034836003777 E3 interaction surface; other site 1034836003778 lipoyl attachment site [posttranslational modification]; other site 1034836003779 e3 binding domain; Region: E3_binding; pfam02817 1034836003780 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1034836003781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836003782 bile acid transporter; Region: bass; TIGR00841 1034836003783 Membrane transport protein; Region: Mem_trans; cl09117 1034836003784 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1034836003785 Na2 binding site [ion binding]; other site 1034836003786 putative substrate binding site 1 [chemical binding]; other site 1034836003787 Na binding site 1 [ion binding]; other site 1034836003788 putative substrate binding site 2 [chemical binding]; other site 1034836003789 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1034836003790 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1034836003791 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1034836003792 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1034836003793 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1034836003794 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1034836003795 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1034836003796 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836003797 NAD(P) binding site [chemical binding]; other site 1034836003798 catalytic residues [active] 1034836003799 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1034836003800 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1034836003801 putative dimer interface [polypeptide binding]; other site 1034836003802 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1034836003803 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836003804 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1034836003805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836003806 ATP binding site [chemical binding]; other site 1034836003807 putative Mg++ binding site [ion binding]; other site 1034836003808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836003809 nucleotide binding region [chemical binding]; other site 1034836003810 ATP-binding site [chemical binding]; other site 1034836003811 RQC domain; Region: RQC; cl09632 1034836003812 HRDC domain; Region: HRDC; cl02578 1034836003813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836003815 3D domain; Region: 3D; cl01439 1034836003816 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1034836003817 putative dimer interface [polypeptide binding]; other site 1034836003818 catalytic triad [active] 1034836003819 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836003820 Protein of unknown function (DUF420); Region: DUF420; cl00989 1034836003821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1034836003822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034836003823 catalytic residue [active] 1034836003824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836003825 dimerization interface [polypeptide binding]; other site 1034836003826 putative DNA binding site [nucleotide binding]; other site 1034836003827 putative Zn2+ binding site [ion binding]; other site 1034836003828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836003829 Helix-turn-helix domains; Region: HTH; cl00088 1034836003830 WHG domain; Region: WHG; pfam13305 1034836003831 Cupin domain; Region: Cupin_2; cl09118 1034836003832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836003833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034836003834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836003835 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1034836003836 dimer interface [polypeptide binding]; other site 1034836003837 putative tRNA-binding site [nucleotide binding]; other site 1034836003838 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1034836003839 Helix-turn-helix domains; Region: HTH; cl00088 1034836003840 Helix-turn-helix domains; Region: HTH; cl00088 1034836003841 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1034836003842 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1034836003843 putative [4Fe-4S] binding site [ion binding]; other site 1034836003844 putative molybdopterin cofactor binding site [chemical binding]; other site 1034836003845 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1034836003846 putative molybdopterin cofactor binding site; other site 1034836003847 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1034836003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003849 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1034836003850 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1034836003851 putative N- and C-terminal domain interface [polypeptide binding]; other site 1034836003852 putative active site [active] 1034836003853 putative MgATP binding site [chemical binding]; other site 1034836003854 catalytic site [active] 1034836003855 metal binding site [ion binding]; metal-binding site 1034836003856 carbohydrate binding site [chemical binding]; other site 1034836003857 polyol permease family; Region: 2A0118; TIGR00897 1034836003858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836003859 putative substrate translocation pore; other site 1034836003860 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1034836003861 classical (c) SDRs; Region: SDR_c; cd05233 1034836003862 NAD(P) binding site [chemical binding]; other site 1034836003863 active site 1034836003864 Replication terminator protein; Region: RTP; pfam02334 1034836003865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003866 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1034836003867 gamma-glutamyl kinase; Provisional; Region: PRK13402 1034836003868 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1034836003869 nucleotide binding site [chemical binding]; other site 1034836003870 homotetrameric interface [polypeptide binding]; other site 1034836003871 putative phosphate binding site [ion binding]; other site 1034836003872 putative allosteric binding site; other site 1034836003873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836003874 Helix-turn-helix domains; Region: HTH; cl00088 1034836003875 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1034836003876 putative dimerization interface [polypeptide binding]; other site 1034836003877 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1034836003878 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1034836003879 active site 1034836003880 dimer interface [polypeptide binding]; other site 1034836003881 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1034836003882 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1034836003883 active site 1034836003884 FMN binding site [chemical binding]; other site 1034836003885 substrate binding site [chemical binding]; other site 1034836003886 3Fe-4S cluster binding site [ion binding]; other site 1034836003887 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1034836003888 domain interface; other site 1034836003889 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1034836003890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836003891 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1034836003892 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1034836003893 NAD(P) binding site [chemical binding]; other site 1034836003894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836003895 Helix-turn-helix domains; Region: HTH; cl00088 1034836003896 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1034836003897 putative dimerization interface [polypeptide binding]; other site 1034836003898 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1034836003899 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1034836003900 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1034836003901 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1034836003902 active site 1034836003903 dimer interface [polypeptide binding]; other site 1034836003904 motif 1; other site 1034836003905 motif 2; other site 1034836003906 motif 3; other site 1034836003907 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1034836003908 anticodon binding site; other site 1034836003909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836003910 dimerization interface [polypeptide binding]; other site 1034836003911 putative DNA binding site [nucleotide binding]; other site 1034836003912 putative Zn2+ binding site [ion binding]; other site 1034836003913 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836003914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836003915 putative substrate translocation pore; other site 1034836003916 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1034836003917 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1034836003918 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836003919 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1034836003920 Int/Topo IB signature motif; other site 1034836003921 MatE; Region: MatE; cl10513 1034836003922 MatE; Region: MatE; cl10513 1034836003923 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1034836003924 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1034836003925 active site 1034836003926 catalytic residues [active] 1034836003927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836003928 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1034836003929 peptide synthase; Provisional; Region: PRK12467 1034836003930 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836003931 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003932 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003933 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836003934 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034836003935 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836003936 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003937 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003938 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836003939 Condensation domain; Region: Condensation; pfam00668 1034836003940 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836003941 peptide synthase; Provisional; Region: PRK12467 1034836003942 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003943 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836003945 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1034836003946 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1034836003947 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1034836003948 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1034836003949 FAD binding site [chemical binding]; other site 1034836003950 homotetramer interface [polypeptide binding]; other site 1034836003951 substrate binding pocket [chemical binding]; other site 1034836003952 catalytic base [active] 1034836003953 AMP-binding domain protein; Validated; Region: PRK08315 1034836003954 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836003955 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836003956 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1034836003957 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836003958 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836003959 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1034836003960 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034836003961 carboxyltransferase (CT) interaction site; other site 1034836003962 biotinylation site [posttranslational modification]; other site 1034836003963 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1034836003964 active site 1034836003965 catalytic residues [active] 1034836003966 metal binding site [ion binding]; metal-binding site 1034836003967 enoyl-CoA hydratase; Provisional; Region: PRK07657 1034836003968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836003969 substrate binding site [chemical binding]; other site 1034836003970 oxyanion hole (OAH) forming residues; other site 1034836003971 trimer interface [polypeptide binding]; other site 1034836003972 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1034836003973 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836003974 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836003975 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1034836003976 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836003977 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1034836003978 active site 1034836003979 tetramer interface; other site 1034836003980 GtrA-like protein; Region: GtrA; cl00971 1034836003981 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1034836003982 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1034836003983 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1034836003984 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836003985 inhibitor-cofactor binding pocket; inhibition site 1034836003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003987 catalytic residue [active] 1034836003988 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1034836003989 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1034836003990 substrate-cofactor binding pocket; other site 1034836003991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836003992 catalytic residue [active] 1034836003993 AAA domain; Region: AAA_26; pfam13500 1034836003994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836003996 biotin synthase; Validated; Region: PRK06256 1034836003997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836003998 FeS/SAM binding site; other site 1034836003999 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1034836004000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836004001 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836004002 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836004003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004004 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1034836004005 NAD(P) binding site [chemical binding]; other site 1034836004006 active site 1034836004007 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1034836004008 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1034836004009 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1034836004010 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004011 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004012 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004013 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004014 active site 1034836004015 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004016 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004017 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1034836004018 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836004019 inhibitor-cofactor binding pocket; inhibition site 1034836004020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836004021 catalytic residue [active] 1034836004022 Condensation domain; Region: Condensation; pfam00668 1034836004023 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034836004024 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004025 peptide synthase; Provisional; Region: PRK12467 1034836004026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004027 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004028 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004029 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004030 peptide synthase; Provisional; Region: PRK12467 1034836004031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004032 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004033 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836004035 peptide synthase; Provisional; Region: PRK12316 1034836004036 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004037 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004038 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836004039 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004040 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004041 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004042 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004043 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004044 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004045 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034836004046 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004047 peptide synthase; Provisional; Region: PRK12467 1034836004048 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004049 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004050 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034836004051 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004052 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004053 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1034836004054 substrate binding site [chemical binding]; other site 1034836004055 active site 1034836004056 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1034836004057 metal binding site [ion binding]; metal-binding site 1034836004058 ligand binding site [chemical binding]; other site 1034836004059 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1034836004060 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1034836004061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836004062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836004063 active site 1034836004064 phosphorylation site [posttranslational modification] 1034836004065 intermolecular recognition site; other site 1034836004066 dimerization interface [polypeptide binding]; other site 1034836004067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836004068 DNA binding site [nucleotide binding] 1034836004069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1034836004070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836004071 dimer interface [polypeptide binding]; other site 1034836004072 phosphorylation site [posttranslational modification] 1034836004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836004074 ATP binding site [chemical binding]; other site 1034836004075 Mg2+ binding site [ion binding]; other site 1034836004076 G-X-G motif; other site 1034836004077 YndJ-like protein; Region: YndJ; pfam14158 1034836004078 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1034836004079 potential frameshift: common BLAST hit: gi|308173794|ref|YP_003920499.1| YndG 1034836004080 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1034836004081 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1034836004082 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1034836004083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1034836004084 CAP-like domain; other site 1034836004085 active site 1034836004086 primary dimer interface [polypeptide binding]; other site 1034836004087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836004088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836004089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836004090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034836004091 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1034836004092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836004093 ATP binding site [chemical binding]; other site 1034836004094 Mg2+ binding site [ion binding]; other site 1034836004095 G-X-G motif; other site 1034836004096 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1034836004097 anchoring element; other site 1034836004098 dimer interface [polypeptide binding]; other site 1034836004099 ATP binding site [chemical binding]; other site 1034836004100 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1034836004101 active site 1034836004102 putative metal-binding site [ion binding]; other site 1034836004103 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1034836004104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004105 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1034836004106 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1034836004107 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1034836004108 active site 1034836004109 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 1034836004110 Small acid-soluble spore protein N family; Region: SspN; cl11659 1034836004111 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1034836004112 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1034836004113 catalytic residues [active] 1034836004114 aconitate hydratase; Validated; Region: PRK09277 1034836004115 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1034836004116 substrate binding site [chemical binding]; other site 1034836004117 ligand binding site [chemical binding]; other site 1034836004118 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1034836004119 substrate binding site [chemical binding]; other site 1034836004120 Small acid-soluble spore protein O family; Region: SspO; cl07943 1034836004121 Small acid-soluble spore protein P family; Region: SspP; cl12105 1034836004122 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1034836004123 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1034836004124 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1034836004125 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836004127 active site 1034836004128 phosphorylation site [posttranslational modification] 1034836004129 intermolecular recognition site; other site 1034836004130 dimerization interface [polypeptide binding]; other site 1034836004131 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1034836004132 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1034836004133 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1034836004134 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1034836004135 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 1034836004136 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1034836004137 TPP-binding site [chemical binding]; other site 1034836004138 dimer interface [polypeptide binding]; other site 1034836004139 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1034836004140 PYR/PP interface [polypeptide binding]; other site 1034836004141 dimer interface [polypeptide binding]; other site 1034836004142 TPP binding site [chemical binding]; other site 1034836004143 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034836004144 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1034836004145 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1034836004146 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1034836004147 catalytic residues [active] 1034836004148 catalytic nucleophile [active] 1034836004149 cell division suppressor protein YneA; Provisional; Region: PRK14125 1034836004150 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1034836004151 LexA repressor; Validated; Region: PRK00215 1034836004152 Helix-turn-helix domains; Region: HTH; cl00088 1034836004153 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1034836004154 Catalytic site [active] 1034836004155 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1034836004156 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1034836004157 Protein of unknown function (DUF867); Region: DUF867; cl01713 1034836004158 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1034836004159 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1034836004160 trimer interface [polypeptide binding]; other site 1034836004161 active site 1034836004162 TM2 domain; Region: TM2; cl00984 1034836004163 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836004164 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1034836004165 Chitin binding domain; Region: Chitin_bind_3; cl03871 1034836004166 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1034836004167 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034836004168 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1034836004169 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1034836004170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034836004171 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836004172 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836004173 YoaP-like; Region: YoaP; pfam14268 1034836004174 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1034836004175 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1034836004176 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1034836004177 NAD binding site [chemical binding]; other site 1034836004178 substrate binding site [chemical binding]; other site 1034836004179 catalytic Zn binding site [ion binding]; other site 1034836004180 tetramer interface [polypeptide binding]; other site 1034836004181 structural Zn binding site [ion binding]; other site 1034836004182 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836004183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836004184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034836004185 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1034836004186 putative NAD(P) binding site [chemical binding]; other site 1034836004187 catalytic Zn binding site [ion binding]; other site 1034836004188 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034836004189 Helix-turn-helix domains; Region: HTH; cl00088 1034836004190 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1034836004191 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1034836004192 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1034836004193 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1034836004194 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1034836004195 N- and C-terminal domain interface [polypeptide binding]; other site 1034836004196 D-xylulose kinase; Region: XylB; TIGR01312 1034836004197 active site 1034836004198 catalytic site [active] 1034836004199 metal binding site [ion binding]; metal-binding site 1034836004200 xylulose binding site [chemical binding]; other site 1034836004201 putative ATP binding site [chemical binding]; other site 1034836004202 homodimer interface [polypeptide binding]; other site 1034836004203 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1034836004204 Helix-turn-helix domains; Region: HTH; cl00088 1034836004205 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1034836004206 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1034836004207 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1034836004208 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1034836004209 inhibitor binding site; inhibition site 1034836004210 active site 1034836004211 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1034836004212 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836004213 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836004214 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1034836004215 glutamine synthetase, type I; Region: GlnA; TIGR00653 1034836004216 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1034836004217 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1034836004218 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1034836004219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034836004220 DNA binding residues [nucleotide binding] 1034836004221 putative dimer interface [polypeptide binding]; other site 1034836004222 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1034836004223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836004224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836004225 catalytic residue [active] 1034836004226 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1034836004227 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1034836004228 HflX GTPase family; Region: HflX; cd01878 1034836004229 G1 box; other site 1034836004230 GTP/Mg2+ binding site [chemical binding]; other site 1034836004231 Switch I region; other site 1034836004232 G2 box; other site 1034836004233 G3 box; other site 1034836004234 Switch II region; other site 1034836004235 G4 box; other site 1034836004236 G5 box; other site 1034836004237 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1034836004238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836004239 Walker A motif; other site 1034836004240 ATP binding site [chemical binding]; other site 1034836004241 Walker B motif; other site 1034836004242 arginine finger; other site 1034836004243 potential frameshift: common BLAST hit: gi|154686154|ref|YP_001421315.1| CwlC 1034836004244 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1034836004245 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1034836004246 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1034836004247 dimer interface [polypeptide binding]; other site 1034836004248 putative radical transfer pathway; other site 1034836004249 diiron center [ion binding]; other site 1034836004250 tyrosyl radical; other site 1034836004251 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1034836004252 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1034836004253 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1034836004254 active site 1034836004255 dimer interface [polypeptide binding]; other site 1034836004256 catalytic residues [active] 1034836004257 effector binding site; other site 1034836004258 R2 peptide binding site; other site 1034836004259 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836004260 YmzC-like protein; Region: YmzC; pfam14157 1034836004261 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 1034836004262 Sm1 motif; other site 1034836004263 intra - hexamer interaction site; other site 1034836004264 inter - hexamer interaction site [polypeptide binding]; other site 1034836004265 nucleotide binding pocket [chemical binding]; other site 1034836004266 Sm2 motif; other site 1034836004267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836004268 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1034836004269 YmaF family; Region: YmaF; pfam12788 1034836004270 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836004271 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836004272 OsmC-like protein; Region: OsmC; cl00767 1034836004273 Protein of unknown function (DUF867); Region: DUF867; cl01713 1034836004274 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1034836004275 active site 1034836004276 catalytic triad [active] 1034836004277 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1034836004278 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1034836004279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836004280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836004281 S-adenosylmethionine binding site [chemical binding]; other site 1034836004282 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004284 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004285 active site 1034836004286 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004287 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1034836004288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004289 active site 1034836004290 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004291 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004292 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1034836004293 Condensation domain; Region: Condensation; pfam00668 1034836004294 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034836004295 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004296 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004297 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004298 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004299 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004300 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004301 active site 1034836004302 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004303 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004304 putative NADP binding site [chemical binding]; other site 1034836004305 active site 1034836004306 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004307 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004308 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004309 active site 1034836004310 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004311 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004312 putative NADP binding site [chemical binding]; other site 1034836004313 active site 1034836004314 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004315 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004317 active site 1034836004318 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004319 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004320 putative NADP binding site [chemical binding]; other site 1034836004321 active site 1034836004322 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004323 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004324 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004325 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004326 active site 1034836004327 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004328 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004329 putative NADP binding site [chemical binding]; other site 1034836004330 active site 1034836004331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836004332 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004333 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004334 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004335 active site 1034836004336 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004337 putative NADP binding site [chemical binding]; other site 1034836004338 active site 1034836004339 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004340 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004343 active site 1034836004344 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004345 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004346 putative NADP binding site [chemical binding]; other site 1034836004347 active site 1034836004348 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004349 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004350 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004351 active site 1034836004352 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004353 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004354 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004355 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004356 active site 1034836004357 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004358 putative NADP binding site [chemical binding]; other site 1034836004359 active site 1034836004360 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004361 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004362 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004363 active site 1034836004364 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1034836004365 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004367 Condensation domain; Region: Condensation; pfam00668 1034836004368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034836004369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836004370 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836004371 acyl-CoA synthetase; Validated; Region: PRK08308 1034836004372 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004373 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004374 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004375 active site 1034836004376 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1034836004377 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004378 putative NADP binding site [chemical binding]; other site 1034836004379 active site 1034836004380 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004382 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1034836004383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004384 active site 1034836004385 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1034836004386 putative NADP binding site [chemical binding]; other site 1034836004387 active site 1034836004388 peptide synthase; Provisional; Region: PRK12316 1034836004389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004390 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1034836004391 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1034836004392 active site 1034836004393 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1034836004394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836004395 substrate binding site [chemical binding]; other site 1034836004396 oxyanion hole (OAH) forming residues; other site 1034836004397 trimer interface [polypeptide binding]; other site 1034836004398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836004399 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1034836004400 substrate binding site [chemical binding]; other site 1034836004401 oxyanion hole (OAH) forming residues; other site 1034836004402 trimer interface [polypeptide binding]; other site 1034836004403 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1034836004404 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1034836004405 dimer interface [polypeptide binding]; other site 1034836004406 active site 1034836004407 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004408 potential frameshift: common BLAST hit: gi|154686126|ref|YP_001421287.1| BaeE 1034836004409 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1034836004410 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1034836004411 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1034836004412 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1034836004413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836004414 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1034836004415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836004416 ATP binding site [chemical binding]; other site 1034836004417 Mg2+ binding site [ion binding]; other site 1034836004418 G-X-G motif; other site 1034836004419 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1034836004420 ATP binding site [chemical binding]; other site 1034836004421 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1034836004422 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1034836004423 MutS domain I; Region: MutS_I; pfam01624 1034836004424 MutS domain II; Region: MutS_II; pfam05188 1034836004425 MutS family domain IV; Region: MutS_IV; pfam05190 1034836004426 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1034836004427 Walker A/P-loop; other site 1034836004428 ATP binding site [chemical binding]; other site 1034836004429 Q-loop/lid; other site 1034836004430 ABC transporter signature motif; other site 1034836004431 Walker B; other site 1034836004432 D-loop; other site 1034836004433 H-loop/switch region; other site 1034836004434 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1034836004435 Protein of unknown function (DUF964); Region: DUF964; cl01483 1034836004436 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1034836004437 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1034836004438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836004439 FeS/SAM binding site; other site 1034836004440 TRAM domain; Region: TRAM; cl01282 1034836004441 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1034836004442 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1034836004443 substrate-cofactor binding pocket; other site 1034836004444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836004445 catalytic residue [active] 1034836004446 Threonine dehydrogenase; Region: TDH; cd05281 1034836004447 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1034836004448 structural Zn binding site [ion binding]; other site 1034836004449 catalytic Zn binding site [ion binding]; other site 1034836004450 tetramer interface [polypeptide binding]; other site 1034836004451 NADP binding site [chemical binding]; other site 1034836004452 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1034836004453 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1034836004454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034836004455 putative active site [active] 1034836004456 metal binding site [ion binding]; metal-binding site 1034836004457 homodimer binding site [polypeptide binding]; other site 1034836004458 phosphodiesterase; Provisional; Region: PRK12704 1034836004459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1034836004460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836004461 recombinase A; Provisional; Region: recA; PRK09354 1034836004462 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1034836004463 hexamer interface [polypeptide binding]; other site 1034836004464 Walker A motif; other site 1034836004465 ATP binding site [chemical binding]; other site 1034836004466 Walker B motif; other site 1034836004467 competence damage-inducible protein A; Provisional; Region: PRK00549 1034836004468 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1034836004469 putative MPT binding site; other site 1034836004470 Competence-damaged protein; Region: CinA; cl00666 1034836004471 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1034836004472 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1034836004473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836004474 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1034836004475 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1034836004476 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1034836004477 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1034836004478 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1034836004479 classical (c) SDRs; Region: SDR_c; cd05233 1034836004480 NAD(P) binding site [chemical binding]; other site 1034836004481 active site 1034836004482 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1034836004483 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1034836004484 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1034836004485 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1034836004486 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1034836004487 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1034836004488 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1034836004489 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1034836004490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836004491 Helix-turn-helix domains; Region: HTH; cl00088 1034836004492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836004493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836004494 putative substrate translocation pore; other site 1034836004495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034836004496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836004497 DNA-binding site [nucleotide binding]; DNA binding site 1034836004498 UTRA domain; Region: UTRA; cl01230 1034836004499 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1034836004500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836004501 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1034836004502 YlzJ-like protein; Region: YlzJ; pfam14035 1034836004503 Clp protease; Region: CLP_protease; pfam00574 1034836004504 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1034836004505 active site 1034836004506 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1034836004507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836004508 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1034836004509 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1034836004510 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1034836004511 dimer interface [polypeptide binding]; other site 1034836004512 active site 1034836004513 catalytic residue [active] 1034836004514 aspartate kinase I; Reviewed; Region: PRK08210 1034836004515 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1034836004516 putative catalytic residues [active] 1034836004517 putative nucleotide binding site [chemical binding]; other site 1034836004518 putative aspartate binding site [chemical binding]; other site 1034836004519 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1034836004520 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1034836004521 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1034836004522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1034836004524 Flavoprotein; Region: Flavoprotein; cl08021 1034836004525 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1034836004526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004527 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1034836004528 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1034836004529 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1034836004530 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1034836004531 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1034836004532 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1034836004533 NodB motif; other site 1034836004534 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1034836004535 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1034836004536 RNase E interface [polypeptide binding]; other site 1034836004537 trimer interface [polypeptide binding]; other site 1034836004538 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1034836004539 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1034836004540 RNase E interface [polypeptide binding]; other site 1034836004541 trimer interface [polypeptide binding]; other site 1034836004542 active site 1034836004543 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1034836004544 putative nucleic acid binding region [nucleotide binding]; other site 1034836004545 G-X-X-G motif; other site 1034836004546 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1034836004547 RNA binding site [nucleotide binding]; other site 1034836004548 domain interface; other site 1034836004549 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1034836004550 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1034836004551 active site 1034836004552 Riboflavin kinase; Region: Flavokinase; cl03312 1034836004553 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1034836004554 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1034836004555 RNA binding site [nucleotide binding]; other site 1034836004556 active site 1034836004557 Ribosome-binding factor A; Region: RBFA; cl00542 1034836004558 Protein of unknown function (DUF503); Region: DUF503; cl00669 1034836004559 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1034836004560 translation initiation factor IF-2; Region: IF-2; TIGR00487 1034836004561 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1034836004562 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1034836004563 G1 box; other site 1034836004564 putative GEF interaction site [polypeptide binding]; other site 1034836004565 GTP/Mg2+ binding site [chemical binding]; other site 1034836004566 Switch I region; other site 1034836004567 G2 box; other site 1034836004568 G3 box; other site 1034836004569 Switch II region; other site 1034836004570 G4 box; other site 1034836004571 G5 box; other site 1034836004572 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1034836004573 Translation-initiation factor 2; Region: IF-2; pfam11987 1034836004574 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1034836004575 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1034836004576 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1034836004577 putative RNA binding cleft [nucleotide binding]; other site 1034836004578 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1034836004579 NusA N-terminal domain; Region: NusA_N; pfam08529 1034836004580 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1034836004581 RNA binding site [nucleotide binding]; other site 1034836004582 homodimer interface [polypeptide binding]; other site 1034836004583 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1034836004584 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1034836004585 G-X-X-G motif; other site 1034836004586 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1034836004587 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1034836004588 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 1034836004589 Sm1 motif; other site 1034836004590 predicted subunit interaction site [polypeptide binding]; other site 1034836004591 RNA binding pocket [nucleotide binding]; other site 1034836004592 Sm2 motif; other site 1034836004593 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1034836004594 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1034836004595 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1034836004596 generic binding surface II; other site 1034836004597 generic binding surface I; other site 1034836004598 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1034836004599 active site 1034836004600 catalytic site [active] 1034836004601 substrate binding site [chemical binding]; other site 1034836004602 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1034836004603 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1034836004604 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1034836004605 dimer interface [polypeptide binding]; other site 1034836004606 motif 1; other site 1034836004607 active site 1034836004608 motif 2; other site 1034836004609 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1034836004610 putative deacylase active site [active] 1034836004611 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1034836004612 active site 1034836004613 motif 3; other site 1034836004614 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1034836004615 anticodon binding site; other site 1034836004616 RIP metalloprotease RseP; Region: TIGR00054 1034836004617 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1034836004618 active site 1034836004619 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1034836004620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1034836004621 protein binding site [polypeptide binding]; other site 1034836004622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1034836004623 putative substrate binding region [chemical binding]; other site 1034836004624 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1034836004625 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1034836004626 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1034836004627 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1034836004628 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1034836004629 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1034836004630 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1034836004631 catalytic residue [active] 1034836004632 putative FPP diphosphate binding site; other site 1034836004633 putative FPP binding hydrophobic cleft; other site 1034836004634 dimer interface [polypeptide binding]; other site 1034836004635 putative IPP diphosphate binding site; other site 1034836004636 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1034836004637 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1034836004638 hinge region; other site 1034836004639 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1034836004640 putative nucleotide binding site [chemical binding]; other site 1034836004641 uridine monophosphate binding site [chemical binding]; other site 1034836004642 homohexameric interface [polypeptide binding]; other site 1034836004643 elongation factor Ts; Provisional; Region: tsf; PRK09377 1034836004644 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1034836004645 Elongation factor TS; Region: EF_TS; pfam00889 1034836004646 Elongation factor TS; Region: EF_TS; pfam00889 1034836004647 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1034836004648 rRNA interaction site [nucleotide binding]; other site 1034836004649 S8 interaction site; other site 1034836004650 putative laminin-1 binding site; other site 1034836004651 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1034836004652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836004653 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034836004654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836004655 DNA binding residues [nucleotide binding] 1034836004656 CheD chemotactic sensory transduction; Region: CheD; cl00810 1034836004657 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1034836004658 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1034836004659 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1034836004660 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1034836004661 putative CheA interaction surface; other site 1034836004662 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1034836004663 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1034836004664 putative binding surface; other site 1034836004665 active site 1034836004666 P2 response regulator binding domain; Region: P2; pfam07194 1034836004667 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1034836004668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836004669 ATP binding site [chemical binding]; other site 1034836004670 Mg2+ binding site [ion binding]; other site 1034836004671 G-X-G motif; other site 1034836004672 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1034836004673 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1034836004674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836004675 active site 1034836004676 phosphorylation site [posttranslational modification] 1034836004677 intermolecular recognition site; other site 1034836004678 dimerization interface [polypeptide binding]; other site 1034836004679 CheB methylesterase; Region: CheB_methylest; pfam01339 1034836004680 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1034836004681 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1034836004682 P-loop; other site 1034836004683 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1034836004684 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1034836004685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836004686 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1034836004687 FHIPEP family; Region: FHIPEP; pfam00771 1034836004688 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1034836004689 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1034836004690 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1034836004691 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1034836004692 FliP family; Region: FliP; cl00593 1034836004693 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1034836004694 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836004695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836004696 active site 1034836004697 phosphorylation site [posttranslational modification] 1034836004698 intermolecular recognition site; other site 1034836004699 dimerization interface [polypeptide binding]; other site 1034836004700 flagellar motor switch protein; Validated; Region: PRK08119 1034836004701 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1034836004702 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1034836004703 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1034836004704 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1034836004705 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1034836004706 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1034836004707 Flagellar protein (FlbD); Region: FlbD; cl00683 1034836004708 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1034836004709 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1034836004710 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1034836004711 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1034836004712 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1034836004713 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1034836004714 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1034836004715 MgtE intracellular N domain; Region: MgtE_N; cl15244 1034836004716 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1034836004717 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1034836004718 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1034836004719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1034836004720 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1034836004721 Walker A motif/ATP binding site; other site 1034836004722 Walker B motif; other site 1034836004723 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1034836004724 Flagellar assembly protein FliH; Region: FliH; pfam02108 1034836004725 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1034836004726 MgtE intracellular N domain; Region: MgtE_N; cl15244 1034836004727 FliG C-terminal domain; Region: FliG_C; pfam01706 1034836004728 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1034836004729 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1034836004730 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1034836004731 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1034836004732 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1034836004733 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1034836004734 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1034836004735 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1034836004736 transcriptional repressor CodY; Validated; Region: PRK04158 1034836004737 CodY GAF-like domain; Region: CodY; pfam06018 1034836004738 Helix-turn-helix domains; Region: HTH; cl00088 1034836004739 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1034836004740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836004741 Walker A motif; other site 1034836004742 ATP binding site [chemical binding]; other site 1034836004743 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836004744 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1034836004745 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1034836004746 active site 1034836004747 HslU subunit interaction site [polypeptide binding]; other site 1034836004748 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1034836004749 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1034836004750 active site 1034836004751 Int/Topo IB signature motif; other site 1034836004752 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1034836004753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004754 DNA topoisomerase I; Validated; Region: PRK05582 1034836004755 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1034836004756 active site 1034836004757 interdomain interaction site; other site 1034836004758 putative metal-binding site [ion binding]; other site 1034836004759 nucleotide binding site [chemical binding]; other site 1034836004760 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1034836004761 domain I; other site 1034836004762 DNA binding groove [nucleotide binding] 1034836004763 phosphate binding site [ion binding]; other site 1034836004764 domain II; other site 1034836004765 domain III; other site 1034836004766 nucleotide binding site [chemical binding]; other site 1034836004767 catalytic site [active] 1034836004768 domain IV; other site 1034836004769 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1034836004770 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1034836004771 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1034836004772 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1034836004773 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1034836004774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004775 CoA-ligase; Region: Ligase_CoA; cl02894 1034836004776 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1034836004777 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836004778 CoA-ligase; Region: Ligase_CoA; cl02894 1034836004779 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1034836004780 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1034836004781 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034836004782 active site 1034836004783 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1034836004784 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1034836004785 GTP/Mg2+ binding site [chemical binding]; other site 1034836004786 G4 box; other site 1034836004787 G5 box; other site 1034836004788 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1034836004789 G1 box; other site 1034836004790 G1 box; other site 1034836004791 GTP/Mg2+ binding site [chemical binding]; other site 1034836004792 Switch I region; other site 1034836004793 G2 box; other site 1034836004794 G2 box; other site 1034836004795 G3 box; other site 1034836004796 G3 box; other site 1034836004797 Switch II region; other site 1034836004798 Switch II region; other site 1034836004799 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1034836004800 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1034836004801 RimM N-terminal domain; Region: RimM; pfam01782 1034836004802 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1034836004803 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1034836004804 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1034836004805 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1034836004806 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1034836004807 signal recognition particle protein; Provisional; Region: PRK10867 1034836004808 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1034836004809 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1034836004810 P loop; other site 1034836004811 GTP binding site [chemical binding]; other site 1034836004812 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1034836004813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836004814 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1034836004815 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1034836004816 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1034836004817 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1034836004818 GTP binding site [chemical binding]; other site 1034836004819 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1034836004820 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1034836004821 Walker A/P-loop; other site 1034836004822 ATP binding site [chemical binding]; other site 1034836004823 Q-loop/lid; other site 1034836004824 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1034836004825 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1034836004826 Q-loop/lid; other site 1034836004827 ABC transporter signature motif; other site 1034836004828 Walker B; other site 1034836004829 D-loop; other site 1034836004830 H-loop/switch region; other site 1034836004831 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1034836004832 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1034836004833 dimerization interface [polypeptide binding]; other site 1034836004834 active site 1034836004835 metal binding site [ion binding]; metal-binding site 1034836004836 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1034836004837 dsRNA binding site [nucleotide binding]; other site 1034836004838 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836004839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1034836004840 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1034836004841 NAD(P) binding site [chemical binding]; other site 1034836004842 homotetramer interface [polypeptide binding]; other site 1034836004843 homodimer interface [polypeptide binding]; other site 1034836004844 active site 1034836004845 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1034836004846 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1034836004847 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1034836004848 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1034836004849 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1034836004850 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1034836004851 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1034836004852 generic binding surface II; other site 1034836004853 ssDNA binding site; other site 1034836004854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836004855 ATP binding site [chemical binding]; other site 1034836004856 putative Mg++ binding site [ion binding]; other site 1034836004857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836004858 nucleotide binding region [chemical binding]; other site 1034836004859 ATP-binding site [chemical binding]; other site 1034836004860 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1034836004861 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1034836004862 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1034836004863 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1034836004864 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1034836004865 putative L-serine binding site [chemical binding]; other site 1034836004866 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1034836004867 DAK2 domain; Region: Dak2; cl03685 1034836004868 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1034836004869 Asp23 family; Region: Asp23; cl00574 1034836004870 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1034836004871 Stage V sporulation protein family; Region: SpoV; cl15455 1034836004872 Thiamine pyrophosphokinase; Region: TPK; cd07995 1034836004873 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1034836004874 active site 1034836004875 dimerization interface [polypeptide binding]; other site 1034836004876 thiamine binding site [chemical binding]; other site 1034836004877 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1034836004878 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1034836004879 substrate binding site [chemical binding]; other site 1034836004880 hexamer interface [polypeptide binding]; other site 1034836004881 metal binding site [ion binding]; metal-binding site 1034836004882 GTPase RsgA; Reviewed; Region: PRK00098 1034836004883 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1034836004884 RNA binding site [nucleotide binding]; other site 1034836004885 homodimer interface [polypeptide binding]; other site 1034836004886 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1034836004887 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1034836004888 GTP/Mg2+ binding site [chemical binding]; other site 1034836004889 G4 box; other site 1034836004890 G5 box; other site 1034836004891 G1 box; other site 1034836004892 Switch I region; other site 1034836004893 G2 box; other site 1034836004894 G3 box; other site 1034836004895 Switch II region; other site 1034836004896 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1034836004897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1034836004898 active site 1034836004899 ATP binding site [chemical binding]; other site 1034836004900 substrate binding site [chemical binding]; other site 1034836004901 activation loop (A-loop); other site 1034836004902 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836004903 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1034836004904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1034836004905 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034836004906 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034836004907 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034836004908 Protein phosphatase 2C; Region: PP2C; pfam00481 1034836004909 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1034836004910 active site 1034836004911 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1034836004912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836004913 FeS/SAM binding site; other site 1034836004914 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1034836004915 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1034836004916 putative RNA binding site [nucleotide binding]; other site 1034836004917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836004918 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1034836004919 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1034836004920 putative active site [active] 1034836004921 substrate binding site [chemical binding]; other site 1034836004922 putative cosubstrate binding site; other site 1034836004923 catalytic site [active] 1034836004924 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1034836004925 substrate binding site [chemical binding]; other site 1034836004926 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1034836004927 active site 1034836004928 catalytic residues [active] 1034836004929 metal binding site [ion binding]; metal-binding site 1034836004930 primosome assembly protein PriA; Validated; Region: PRK05580 1034836004931 primosome assembly protein PriA; Validated; Region: PRK05580 1034836004932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836004933 ATP binding site [chemical binding]; other site 1034836004934 putative Mg++ binding site [ion binding]; other site 1034836004935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836004936 nucleotide binding region [chemical binding]; other site 1034836004937 ATP-binding site [chemical binding]; other site 1034836004938 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1034836004939 Flavoprotein; Region: Flavoprotein; cl08021 1034836004940 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1034836004941 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1034836004942 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1034836004943 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1034836004944 catalytic site [active] 1034836004945 G-X2-G-X-G-K; other site 1034836004946 Domain of unknown function (DUF370); Region: DUF370; cl00898 1034836004947 TIGR00255 family protein; Region: TIGR00255 1034836004948 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1034836004949 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1034836004950 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1034836004951 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1034836004952 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034836004953 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1034836004954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836004955 motif II; other site 1034836004956 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1034836004957 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1034836004958 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1034836004959 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1034836004960 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1034836004961 active site 1034836004962 Na/Ca binding site [ion binding]; other site 1034836004963 catalytic site [active] 1034836004964 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1034836004965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836004966 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1034836004967 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1034836004968 putative active site [active] 1034836004969 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1034836004970 putative active site [active] 1034836004971 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1034836004972 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1034836004973 AAA domain; Region: AAA_33; pfam13671 1034836004974 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1034836004975 ligand-binding site [chemical binding]; other site 1034836004976 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1034836004977 ATP-sulfurylase; Region: ATPS; cd00517 1034836004978 active site 1034836004979 HXXH motif; other site 1034836004980 flexible loop; other site 1034836004981 Phosphate transporter family; Region: PHO4; cl00396 1034836004982 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1034836004983 Active Sites [active] 1034836004984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836004985 active site 1034836004986 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1034836004987 active site 1034836004988 dimer interface [polypeptide binding]; other site 1034836004989 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1034836004990 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1034836004991 heterodimer interface [polypeptide binding]; other site 1034836004992 active site 1034836004993 FMN binding site [chemical binding]; other site 1034836004994 homodimer interface [polypeptide binding]; other site 1034836004995 substrate binding site [chemical binding]; other site 1034836004996 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1034836004997 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1034836004998 FAD binding pocket [chemical binding]; other site 1034836004999 FAD binding motif [chemical binding]; other site 1034836005000 phosphate binding motif [ion binding]; other site 1034836005001 beta-alpha-beta structure motif; other site 1034836005002 NAD binding pocket [chemical binding]; other site 1034836005003 Iron coordination center [ion binding]; other site 1034836005004 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1034836005005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836005006 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836005007 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1034836005008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836005009 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836005010 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1034836005011 IMP binding site; other site 1034836005012 dimer interface [polypeptide binding]; other site 1034836005013 interdomain contacts; other site 1034836005014 partial ornithine binding site; other site 1034836005015 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1034836005016 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1034836005017 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1034836005018 catalytic site [active] 1034836005019 subunit interface [polypeptide binding]; other site 1034836005020 dihydroorotase; Validated; Region: pyrC; PRK09357 1034836005021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034836005022 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1034836005023 active site 1034836005024 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1034836005025 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1034836005026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005027 uracil transporter; Provisional; Region: PRK10720 1034836005028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836005029 active site 1034836005030 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1034836005031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836005032 RNA binding surface [nucleotide binding]; other site 1034836005033 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034836005034 active site 1034836005035 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1034836005036 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1034836005037 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1034836005038 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1034836005039 HIGH motif; other site 1034836005040 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034836005041 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1034836005042 active site 1034836005043 KMSKS motif; other site 1034836005044 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1034836005045 tRNA binding surface [nucleotide binding]; other site 1034836005046 anticodon binding site; other site 1034836005047 DivIVA protein; Region: DivIVA; pfam05103 1034836005048 DivIVA domain; Region: DivI1A_domain; TIGR03544 1034836005049 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1034836005050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836005051 RNA binding surface [nucleotide binding]; other site 1034836005052 YGGT family; Region: YGGT; cl00508 1034836005053 Protein of unknown function (DUF552); Region: DUF552; cl00775 1034836005054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1034836005055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034836005056 catalytic residue [active] 1034836005057 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1034836005058 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1034836005059 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1034836005060 acetylornithine deacetylase; Validated; Region: PRK08596 1034836005061 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034836005062 metal binding site [ion binding]; metal-binding site 1034836005063 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034836005064 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1034836005065 Walker A/P-loop; other site 1034836005066 ATP binding site [chemical binding]; other site 1034836005067 Q-loop/lid; other site 1034836005068 ABC transporter signature motif; other site 1034836005069 Walker B; other site 1034836005070 D-loop; other site 1034836005071 H-loop/switch region; other site 1034836005072 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1034836005073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836005074 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034836005075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836005076 DNA binding residues [nucleotide binding] 1034836005077 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1034836005078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836005079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836005080 DNA binding residues [nucleotide binding] 1034836005081 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1034836005082 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1034836005083 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1034836005084 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1034836005085 active site 1034836005086 catalytic triad [active] 1034836005087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1034836005088 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1034836005089 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836005090 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1034836005091 cell division protein FtsZ; Validated; Region: PRK09330 1034836005092 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1034836005093 nucleotide binding site [chemical binding]; other site 1034836005094 SulA interaction site; other site 1034836005095 cell division protein FtsA; Region: ftsA; TIGR01174 1034836005096 Cell division protein FtsA; Region: FtsA; cl11496 1034836005097 Cell division protein FtsA; Region: FtsA; cl11496 1034836005098 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1034836005099 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1034836005100 Cell division protein FtsQ; Region: FtsQ; pfam03799 1034836005101 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1034836005102 FAD binding domain; Region: FAD_binding_4; pfam01565 1034836005103 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1034836005104 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1034836005105 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1034836005106 active site 1034836005107 homodimer interface [polypeptide binding]; other site 1034836005108 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1034836005109 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1034836005110 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836005111 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034836005112 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1034836005113 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1034836005114 Mg++ binding site [ion binding]; other site 1034836005115 putative catalytic motif [active] 1034836005116 putative substrate binding site [chemical binding]; other site 1034836005117 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1034836005118 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034836005119 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836005120 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034836005121 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1034836005122 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836005123 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836005124 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1034836005125 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034836005126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836005127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836005128 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1034836005129 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1034836005130 Septum formation initiator; Region: DivIC; cl11433 1034836005131 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1034836005132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836005133 mraZ protein; Region: TIGR00242 1034836005134 MraZ protein; Region: MraZ; pfam02381 1034836005135 MraZ protein; Region: MraZ; pfam02381 1034836005136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1034836005137 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1034836005138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005139 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1034836005140 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836005141 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1034836005142 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1034836005143 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1034836005144 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1034836005145 hypothetical protein; Provisional; Region: PRK13670 1034836005146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1034836005147 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1034836005148 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1034836005149 protein binding site [polypeptide binding]; other site 1034836005150 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1034836005151 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1034836005152 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1034836005153 active site 1034836005154 nucleophile elbow; other site 1034836005155 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1034836005156 Nucleoside recognition; Region: Gate; cl00486 1034836005157 Nucleoside recognition; Region: Gate; cl00486 1034836005158 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1034836005159 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1034836005160 active site 1034836005161 (T/H)XGH motif; other site 1034836005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836005163 S-adenosylmethionine binding site [chemical binding]; other site 1034836005164 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1034836005165 Protein of unknown function (DUF964); Region: DUF964; cl01483 1034836005166 YlbE-like protein; Region: YlbE; pfam14003 1034836005167 Putative coat protein; Region: YlbD_coat; pfam14071 1034836005168 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1034836005169 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1034836005170 FOG: CBS domain [General function prediction only]; Region: COG0517 1034836005171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1034836005172 YugN-like family; Region: YugN; pfam08868 1034836005173 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1034836005174 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1034836005175 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1034836005176 Subunit I/III interface [polypeptide binding]; other site 1034836005177 Subunit III/IV interface [polypeptide binding]; other site 1034836005178 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1034836005179 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1034836005180 D-pathway; other site 1034836005181 Putative ubiquinol binding site [chemical binding]; other site 1034836005182 Low-spin heme (heme b) binding site [chemical binding]; other site 1034836005183 Putative water exit pathway; other site 1034836005184 Binuclear center (heme o3/CuB) [ion binding]; other site 1034836005185 K-pathway; other site 1034836005186 Putative proton exit pathway; other site 1034836005187 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1034836005188 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1034836005189 Cytochrome c; Region: Cytochrom_C; cl11414 1034836005190 UbiA prenyltransferase family; Region: UbiA; cl00337 1034836005191 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1034836005192 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1034836005193 pyruvate carboxylase; Reviewed; Region: PRK12999 1034836005194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836005195 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836005196 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1034836005197 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1034836005198 active site 1034836005199 catalytic residues [active] 1034836005200 metal binding site [ion binding]; metal-binding site 1034836005201 homodimer binding site [polypeptide binding]; other site 1034836005202 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034836005203 carboxyltransferase (CT) interaction site; other site 1034836005204 biotinylation site [posttranslational modification]; other site 1034836005205 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1034836005206 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1034836005207 Glutaminase; Region: Glutaminase; cl00907 1034836005208 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1034836005209 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1034836005210 putative active site [active] 1034836005211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836005212 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1034836005213 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1034836005214 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 1034836005215 YlaH-like protein; Region: YlaH; pfam14036 1034836005216 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1034836005217 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1034836005218 G1 box; other site 1034836005219 putative GEF interaction site [polypeptide binding]; other site 1034836005220 GTP/Mg2+ binding site [chemical binding]; other site 1034836005221 Switch I region; other site 1034836005222 G2 box; other site 1034836005223 G3 box; other site 1034836005224 Switch II region; other site 1034836005225 G4 box; other site 1034836005226 G5 box; other site 1034836005227 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1034836005228 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1034836005229 Predicted integral membrane protein [Function unknown]; Region: COG5660 1034836005230 Putative zinc-finger; Region: zf-HC2; cl15806 1034836005231 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1034836005232 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1034836005233 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836005234 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1034836005235 active site 1034836005236 Zn binding site [ion binding]; other site 1034836005237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836005238 Coenzyme A binding pocket [chemical binding]; other site 1034836005239 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1034836005240 active site 1034836005241 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 1034836005242 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1034836005243 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1034836005244 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1034836005245 homodimer interface [polypeptide binding]; other site 1034836005246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836005247 catalytic residue [active] 1034836005248 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1034836005249 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1034836005250 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1034836005251 NodB motif; other site 1034836005252 active site 1034836005253 catalytic site [active] 1034836005254 metal binding site [ion binding]; metal-binding site 1034836005255 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1034836005256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836005258 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034836005259 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034836005260 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034836005261 E3 interaction surface; other site 1034836005262 lipoyl attachment site [posttranslational modification]; other site 1034836005263 e3 binding domain; Region: E3_binding; pfam02817 1034836005264 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1034836005265 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034836005266 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034836005267 alpha subunit interface [polypeptide binding]; other site 1034836005268 TPP binding site [chemical binding]; other site 1034836005269 heterodimer interface [polypeptide binding]; other site 1034836005270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034836005271 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1034836005272 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034836005273 TPP-binding site [chemical binding]; other site 1034836005274 tetramer interface [polypeptide binding]; other site 1034836005275 heterodimer interface [polypeptide binding]; other site 1034836005276 phosphorylation loop region [posttranslational modification] 1034836005277 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1034836005278 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1034836005279 active site 1034836005280 catalytic residues [active] 1034836005281 metal binding site [ion binding]; metal-binding site 1034836005282 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836005283 motif II; other site 1034836005284 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836005285 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Region: PLN02475 1034836005286 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 1034836005287 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1034836005288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836005289 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1034836005290 adenine deaminase; Region: ade; TIGR01178 1034836005291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034836005292 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1034836005293 active site 1034836005294 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034836005295 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1034836005296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005297 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836005298 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1034836005299 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1034836005300 putative active site pocket [active] 1034836005301 dimerization interface [polypeptide binding]; other site 1034836005302 putative catalytic residue [active] 1034836005303 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1034836005304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034836005305 putative active site [active] 1034836005306 heme pocket [chemical binding]; other site 1034836005307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1034836005308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836005309 ATP binding site [chemical binding]; other site 1034836005310 Mg2+ binding site [ion binding]; other site 1034836005311 G-X-G motif; other site 1034836005312 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1034836005313 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1034836005314 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1034836005315 rod-share determining protein MreBH; Provisional; Region: PRK13929 1034836005316 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1034836005317 ATP binding site [chemical binding]; other site 1034836005318 profilin binding site; other site 1034836005319 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1034836005320 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1034836005321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005322 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1034836005323 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1034836005324 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836005325 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836005326 ABC transporter; Region: ABC_tran_2; pfam12848 1034836005327 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1034836005328 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1034836005329 Catalytic site [active] 1034836005330 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1034836005331 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034836005332 active site 1034836005333 phosphorylation site [posttranslational modification] 1034836005334 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1034836005335 active site 1034836005336 P-loop; other site 1034836005337 phosphorylation site [posttranslational modification] 1034836005338 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836005339 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1034836005340 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1034836005341 putative substrate binding site [chemical binding]; other site 1034836005342 putative ATP binding site [chemical binding]; other site 1034836005343 Helix-turn-helix domains; Region: HTH; cl00088 1034836005344 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836005345 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1034836005346 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1034836005347 FtsX-like permease family; Region: FtsX; cl15850 1034836005348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034836005349 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1034836005350 Walker A/P-loop; other site 1034836005351 ATP binding site [chemical binding]; other site 1034836005352 Q-loop/lid; other site 1034836005353 ABC transporter signature motif; other site 1034836005354 Walker B; other site 1034836005355 D-loop; other site 1034836005356 H-loop/switch region; other site 1034836005357 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1034836005358 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1034836005359 Yip1 domain; Region: Yip1; cl12048 1034836005360 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1034836005361 MoaE interaction surface [polypeptide binding]; other site 1034836005362 MoeB interaction surface [polypeptide binding]; other site 1034836005363 thiocarboxylated glycine; other site 1034836005364 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1034836005365 MoaE homodimer interface [polypeptide binding]; other site 1034836005366 MoaD interaction [polypeptide binding]; other site 1034836005367 active site residues [active] 1034836005368 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1034836005369 Walker A motif; other site 1034836005370 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1034836005371 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1034836005372 dimer interface [polypeptide binding]; other site 1034836005373 putative functional site; other site 1034836005374 putative MPT binding site; other site 1034836005375 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1034836005376 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1034836005377 ATP binding site [chemical binding]; other site 1034836005378 substrate interface [chemical binding]; other site 1034836005379 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1034836005380 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1034836005381 GTP binding site; other site 1034836005382 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1034836005383 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1034836005384 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1034836005385 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1034836005386 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 1034836005387 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034836005388 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1034836005389 metal binding site [ion binding]; metal-binding site 1034836005390 putative dimer interface [polypeptide binding]; other site 1034836005391 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1034836005392 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1034836005393 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1034836005394 active site 1034836005395 trimer interface [polypeptide binding]; other site 1034836005396 substrate binding site [chemical binding]; other site 1034836005397 CoA binding site [chemical binding]; other site 1034836005398 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836005399 BNR repeat-like domain; Region: BNR_2; pfam13088 1034836005400 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836005401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836005402 Helix-turn-helix domains; Region: HTH; cl00088 1034836005403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836005404 dimerization interface [polypeptide binding]; other site 1034836005405 FOG: CBS domain [General function prediction only]; Region: COG0517 1034836005406 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1034836005407 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1034836005408 Protein of unknown function (DUF458); Region: DUF458; cl00861 1034836005409 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1034836005410 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1034836005411 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1034836005412 short chain dehydrogenase; Provisional; Region: PRK07677 1034836005413 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1034836005414 NAD(P) binding site [chemical binding]; other site 1034836005415 substrate binding site [chemical binding]; other site 1034836005416 homotetramer interface [polypeptide binding]; other site 1034836005417 active site 1034836005418 homodimer interface [polypeptide binding]; other site 1034836005419 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1034836005420 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1034836005421 putative active site [active] 1034836005422 putative metal binding site [ion binding]; other site 1034836005423 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005424 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1034836005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836005426 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034836005427 putative substrate translocation pore; other site 1034836005428 YkyB-like protein; Region: YkyB; pfam14177 1034836005429 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1034836005430 putative CheA interaction surface; other site 1034836005431 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836005432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836005433 active site 1034836005434 phosphorylation site [posttranslational modification] 1034836005435 intermolecular recognition site; other site 1034836005436 dimerization interface [polypeptide binding]; other site 1034836005437 aminotransferase A; Validated; Region: PRK07683 1034836005438 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836005439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836005440 homodimer interface [polypeptide binding]; other site 1034836005441 catalytic residue [active] 1034836005442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034836005443 putative active site [active] 1034836005444 heme pocket [chemical binding]; other site 1034836005445 PAS fold; Region: PAS; pfam00989 1034836005446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034836005447 putative active site [active] 1034836005448 heme pocket [chemical binding]; other site 1034836005449 PAS fold; Region: PAS; pfam00989 1034836005450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836005451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1034836005452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836005453 dimer interface [polypeptide binding]; other site 1034836005454 phosphorylation site [posttranslational modification] 1034836005455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836005456 ATP binding site [chemical binding]; other site 1034836005457 Mg2+ binding site [ion binding]; other site 1034836005458 G-X-G motif; other site 1034836005459 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034836005460 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836005461 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836005462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836005463 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1034836005464 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1034836005465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005466 Cache domain; Region: Cache_1; pfam02743 1034836005467 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1034836005468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836005469 dimerization interface [polypeptide binding]; other site 1034836005470 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1034836005471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836005472 dimer interface [polypeptide binding]; other site 1034836005473 putative CheW interface [polypeptide binding]; other site 1034836005474 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1034836005475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836005476 FeS/SAM binding site; other site 1034836005477 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1034836005478 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1034836005479 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1034836005480 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1034836005481 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1034836005482 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1034836005483 dimerization domain swap beta strand [polypeptide binding]; other site 1034836005484 regulatory protein interface [polypeptide binding]; other site 1034836005485 active site 1034836005486 regulatory phosphorylation site [posttranslational modification]; other site 1034836005487 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1034836005488 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836005489 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836005490 active site turn [active] 1034836005491 phosphorylation site [posttranslational modification] 1034836005492 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1034836005493 HPr interaction site; other site 1034836005494 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034836005495 active site 1034836005496 phosphorylation site [posttranslational modification] 1034836005497 CAT RNA binding domain; Region: CAT_RBD; cl03904 1034836005498 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1034836005499 PRD domain; Region: PRD; cl15445 1034836005500 PRD domain; Region: PRD; cl15445 1034836005501 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836005502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836005503 DNA binding site [nucleotide binding] 1034836005504 domain linker motif; other site 1034836005505 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1034836005506 putative dimerization interface [polypeptide binding]; other site 1034836005507 putative ligand binding site [chemical binding]; other site 1034836005508 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1034836005509 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1034836005510 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1034836005511 active site 1034836005512 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1034836005513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034836005514 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836005515 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1034836005516 catalytic residues [active] 1034836005517 MatE; Region: MatE; cl10513 1034836005518 MatE; Region: MatE; cl10513 1034836005519 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1034836005520 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1034836005521 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1034836005522 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1034836005523 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1034836005524 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1034836005525 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1034836005526 active site 1034836005527 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1034836005528 Ligand Binding Site [chemical binding]; other site 1034836005529 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1034836005530 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1034836005531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836005532 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1034836005533 Walker A motif; other site 1034836005534 ATP binding site [chemical binding]; other site 1034836005535 Walker B motif; other site 1034836005536 arginine finger; other site 1034836005537 UvrB/uvrC motif; Region: UVR; pfam02151 1034836005538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836005539 Walker A motif; other site 1034836005540 ATP binding site [chemical binding]; other site 1034836005541 Walker B motif; other site 1034836005542 arginine finger; other site 1034836005543 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1034836005544 flagellar motor protein MotA; Validated; Region: PRK08124 1034836005545 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1034836005546 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1034836005547 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1034836005548 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1034836005549 ligand binding site [chemical binding]; other site 1034836005550 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836005551 Helix-turn-helix domains; Region: HTH; cl00088 1034836005552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1034836005553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836005554 dimer interface [polypeptide binding]; other site 1034836005555 phosphorylation site [posttranslational modification] 1034836005556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836005557 ATP binding site [chemical binding]; other site 1034836005558 Mg2+ binding site [ion binding]; other site 1034836005559 G-X-G motif; other site 1034836005560 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1034836005561 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1034836005562 Cupin domain; Region: Cupin_2; cl09118 1034836005563 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1034836005564 intersubunit interface [polypeptide binding]; other site 1034836005565 active site 1034836005566 Zn2+ binding site [ion binding]; other site 1034836005567 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1034836005568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836005569 motif II; other site 1034836005570 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1034836005571 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1034836005572 dimer interface [polypeptide binding]; other site 1034836005573 active site 1034836005574 catalytic residue [active] 1034836005575 metal binding site [ion binding]; metal-binding site 1034836005576 transaminase; Reviewed; Region: PRK08068 1034836005577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836005578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836005579 homodimer interface [polypeptide binding]; other site 1034836005580 catalytic residue [active] 1034836005581 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1034836005582 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1034836005583 putative active site [active] 1034836005584 catalytic triad [active] 1034836005585 putative dimer interface [polypeptide binding]; other site 1034836005586 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836005587 Phosphotransferase enzyme family; Region: APH; pfam01636 1034836005588 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1034836005589 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1034836005590 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1034836005591 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1034836005592 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1034836005593 DNA binding site [nucleotide binding] 1034836005594 active site 1034836005595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836005596 PAS domain; Region: PAS_9; pfam13426 1034836005597 PAS domain; Region: PAS_9; pfam13426 1034836005598 PAS domain S-box; Region: sensory_box; TIGR00229 1034836005599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836005600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836005601 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1034836005602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836005603 dimer interface [polypeptide binding]; other site 1034836005604 phosphorylation site [posttranslational modification] 1034836005605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836005606 ATP binding site [chemical binding]; other site 1034836005607 Mg2+ binding site [ion binding]; other site 1034836005608 G-X-G motif; other site 1034836005609 OpgC protein; Region: OpgC_C; cl00792 1034836005610 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1034836005611 Protein of unknown function (DUF421); Region: DUF421; cl00990 1034836005612 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1034836005613 Cation transport protein; Region: TrkH; cl10514 1034836005614 Peptidase family M48; Region: Peptidase_M48; cl12018 1034836005615 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1034836005616 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1034836005617 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1034836005618 transcription termination factor Rho; Provisional; Region: PRK12678 1034836005619 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1034836005620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836005621 Integral membrane protein TerC family; Region: TerC; cl10468 1034836005622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1034836005623 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836005624 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1034836005625 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1034836005626 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1034836005627 PAS domain; Region: PAS_9; pfam13426 1034836005628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1034836005629 metal binding site [ion binding]; metal-binding site 1034836005630 active site 1034836005631 I-site; other site 1034836005632 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1034836005633 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1034836005634 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1034836005635 putative DNA binding site [nucleotide binding]; other site 1034836005636 putative homodimer interface [polypeptide binding]; other site 1034836005637 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1034836005638 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1034836005639 active site 1034836005640 DNA binding site [nucleotide binding] 1034836005641 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1034836005642 nucleotide binding site [chemical binding]; other site 1034836005643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836005644 Helix-turn-helix domains; Region: HTH; cl00088 1034836005645 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1034836005646 DNA binding residues [nucleotide binding] 1034836005647 putative dimer interface [polypeptide binding]; other site 1034836005648 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1034836005649 MgtE intracellular N domain; Region: MgtE_N; cl15244 1034836005650 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1034836005651 Divalent cation transporter; Region: MgtE; cl00786 1034836005652 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1034836005653 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1034836005654 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005655 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005656 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1034836005657 active site 1034836005658 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1034836005659 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1034836005660 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1034836005661 Walker A/P-loop; other site 1034836005662 ATP binding site [chemical binding]; other site 1034836005663 Q-loop/lid; other site 1034836005664 ABC transporter signature motif; other site 1034836005665 Walker B; other site 1034836005666 D-loop; other site 1034836005667 H-loop/switch region; other site 1034836005668 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1034836005669 Walker A/P-loop; other site 1034836005670 ATP binding site [chemical binding]; other site 1034836005671 Q-loop/lid; other site 1034836005672 ABC transporter signature motif; other site 1034836005673 Walker B; other site 1034836005674 D-loop; other site 1034836005675 H-loop/switch region; other site 1034836005676 Cobalt transport protein; Region: CbiQ; cl00463 1034836005677 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836005678 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1034836005679 active site 1034836005680 catalytic residues [active] 1034836005681 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1034836005682 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1034836005683 THF binding site; other site 1034836005684 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1034836005685 substrate binding site [chemical binding]; other site 1034836005686 THF binding site; other site 1034836005687 zinc-binding site [ion binding]; other site 1034836005688 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1034836005689 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1034836005690 ligand binding site [chemical binding]; other site 1034836005691 flexible hinge region; other site 1034836005692 Helix-turn-helix domains; Region: HTH; cl00088 1034836005693 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1034836005694 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 1034836005695 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034836005696 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1034836005697 putative metal binding site; other site 1034836005698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836005699 binding surface 1034836005700 TPR motif; other site 1034836005701 TPR repeat; Region: TPR_11; pfam13414 1034836005702 OsmC-like protein; Region: OsmC; cl00767 1034836005703 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836005704 Helix-turn-helix domains; Region: HTH; cl00088 1034836005705 OsmC-like protein; Region: OsmC; cl00767 1034836005706 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1034836005707 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1034836005708 putative catalytic cysteine [active] 1034836005709 gamma-glutamyl kinase; Provisional; Region: PRK05429 1034836005710 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1034836005711 nucleotide binding site [chemical binding]; other site 1034836005712 homotetrameric interface [polypeptide binding]; other site 1034836005713 putative phosphate binding site [ion binding]; other site 1034836005714 putative allosteric binding site; other site 1034836005715 PUA domain; Region: PUA; cl00607 1034836005716 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1034836005717 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1034836005718 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1034836005719 putative active site [active] 1034836005720 putative substrate binding site [chemical binding]; other site 1034836005721 putative cosubstrate binding site; other site 1034836005722 catalytic site [active] 1034836005723 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836005724 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034836005725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034836005726 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836005727 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1034836005728 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1034836005729 Amidinotransferase; Region: Amidinotransf; cl12043 1034836005730 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1034836005731 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1034836005732 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836005733 Walker A/P-loop; other site 1034836005734 ATP binding site [chemical binding]; other site 1034836005735 Q-loop/lid; other site 1034836005736 ABC transporter signature motif; other site 1034836005737 Walker B; other site 1034836005738 D-loop; other site 1034836005739 H-loop/switch region; other site 1034836005740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836005741 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836005742 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1034836005743 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1034836005744 active site 1034836005745 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1034836005746 dimer interface [polypeptide binding]; other site 1034836005747 catalytic triad [active] 1034836005748 potential frameshift: common BLAST hit: gi|154685714|ref|YP_001420875.1| DppE 1034836005749 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034836005750 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836005751 Walker A/P-loop; other site 1034836005752 ATP binding site [chemical binding]; other site 1034836005753 Q-loop/lid; other site 1034836005754 ABC transporter signature motif; other site 1034836005755 Walker B; other site 1034836005756 D-loop; other site 1034836005757 H-loop/switch region; other site 1034836005758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836005759 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1034836005760 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1034836005761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836005762 dimer interface [polypeptide binding]; other site 1034836005763 conserved gate region; other site 1034836005764 putative PBP binding loops; other site 1034836005765 ABC-ATPase subunit interface; other site 1034836005766 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034836005767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836005768 dimer interface [polypeptide binding]; other site 1034836005769 conserved gate region; other site 1034836005770 putative PBP binding loops; other site 1034836005771 ABC-ATPase subunit interface; other site 1034836005772 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1034836005773 SxDxEG motif; other site 1034836005774 active site 1034836005775 metal binding site [ion binding]; metal-binding site 1034836005776 homopentamer interface [polypeptide binding]; other site 1034836005777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836005778 putative substrate translocation pore; other site 1034836005779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836005780 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1034836005781 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034836005782 protein binding site [polypeptide binding]; other site 1034836005783 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1034836005784 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1034836005785 Ligand binding site; other site 1034836005786 Putative Catalytic site; other site 1034836005787 DXD motif; other site 1034836005788 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1034836005789 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1034836005790 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1034836005791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836005792 Zn binding site [ion binding]; other site 1034836005793 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1034836005794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836005795 Zn binding site [ion binding]; other site 1034836005796 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1034836005797 Spore germination protein; Region: Spore_permease; cl15802 1034836005798 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1034836005799 Phosphate transporter family; Region: PHO4; cl00396 1034836005800 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1034836005801 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1034836005802 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836005803 amidase catalytic site [active] 1034836005804 Zn binding residues [ion binding]; other site 1034836005805 substrate binding site [chemical binding]; other site 1034836005806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005807 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836005808 Phage lysis protein, holin; Region: Phage_holin; cl04675 1034836005809 Haemolysin XhlA; Region: XhlA; pfam10779 1034836005810 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1034836005811 XkdW protein; Region: XkdW; pfam09636 1034836005812 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1034836005813 Baseplate J-like protein; Region: Baseplate_J; cl01294 1034836005814 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1034836005815 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1034836005816 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1034836005817 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005818 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1034836005819 AAA ATPase domain; Region: AAA_15; pfam13175 1034836005820 membrane protein P6; Region: PHA01399 1034836005821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1034836005822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034836005823 catalytic residue [active] 1034836005824 Phage XkdN-like protein; Region: XkdN; pfam08890 1034836005825 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1034836005826 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1034836005827 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1034836005828 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1034836005829 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1034836005830 Phage capsid family; Region: Phage_capsid; pfam05065 1034836005831 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1034836005832 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1034836005833 Phage terminase large subunit; Region: Terminase_3; cl12054 1034836005834 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1034836005835 Terminase small subunit; Region: Terminase_2; cl01513 1034836005836 positive control sigma-like factor; Validated; Region: PRK06930 1034836005837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836005838 DNA binding residues [nucleotide binding] 1034836005839 putative replication protein; Provisional; Region: PRK12377 1034836005840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836005841 Walker A motif; other site 1034836005842 ATP binding site [chemical binding]; other site 1034836005843 Walker B motif; other site 1034836005844 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034836005845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836005846 non-specific DNA binding site [nucleotide binding]; other site 1034836005847 salt bridge; other site 1034836005848 sequence-specific DNA binding site [nucleotide binding]; other site 1034836005849 Domain of unknown function (DUF955); Region: DUF955; cl01076 1034836005850 Protein of unknown function (DUF867); Region: DUF867; cl01713 1034836005851 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1034836005852 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836005853 amidase catalytic site [active] 1034836005854 Zn binding residues [ion binding]; other site 1034836005855 substrate binding site [chemical binding]; other site 1034836005856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005857 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836005858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836005859 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1034836005860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836005861 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836005862 DinB superfamily; Region: DinB_2; pfam12867 1034836005863 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1034836005864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034836005865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1034836005866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836005867 dimer interface [polypeptide binding]; other site 1034836005868 phosphorylation site [posttranslational modification] 1034836005869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836005870 ATP binding site [chemical binding]; other site 1034836005871 Mg2+ binding site [ion binding]; other site 1034836005872 G-X-G motif; other site 1034836005873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836005874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836005875 active site 1034836005876 phosphorylation site [posttranslational modification] 1034836005877 intermolecular recognition site; other site 1034836005878 dimerization interface [polypeptide binding]; other site 1034836005879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836005880 DNA binding site [nucleotide binding] 1034836005881 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1034836005882 altronate oxidoreductase; Provisional; Region: PRK03643 1034836005883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836005884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836005885 DNA binding site [nucleotide binding] 1034836005886 domain linker motif; other site 1034836005887 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1034836005888 dimerization interface [polypeptide binding]; other site 1034836005889 ligand binding site [chemical binding]; other site 1034836005890 Glucuronate isomerase; Region: UxaC; cl00829 1034836005891 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1034836005892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836005893 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1034836005894 Cupin domain; Region: Cupin_2; cl09118 1034836005895 EamA-like transporter family; Region: EamA; cl01037 1034836005896 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 1034836005897 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1034836005898 Walker A/P-loop; other site 1034836005899 ATP binding site [chemical binding]; other site 1034836005900 Q-loop/lid; other site 1034836005901 ABC transporter signature motif; other site 1034836005902 Walker B; other site 1034836005903 D-loop; other site 1034836005904 H-loop/switch region; other site 1034836005905 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1034836005906 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1034836005907 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1034836005908 active site 1034836005909 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1034836005910 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1034836005911 active site 1034836005912 TDP-binding site; other site 1034836005913 acceptor substrate-binding pocket; other site 1034836005914 homodimer interface [polypeptide binding]; other site 1034836005915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836005916 Cytochrome P450; Region: p450; pfam00067 1034836005917 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1034836005918 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1034836005919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1034836005920 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1034836005921 4Fe-4S binding domain; Region: Fer4; cl02805 1034836005922 4Fe-4S binding domain; Region: Fer4; cl02805 1034836005923 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1034836005924 [4Fe-4S] binding site [ion binding]; other site 1034836005925 molybdopterin cofactor binding site; other site 1034836005926 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1034836005927 molybdopterin cofactor binding site; other site 1034836005928 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1034836005929 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1034836005930 Putative motility protein; Region: YjfB_motility; pfam14070 1034836005931 MgtC family; Region: MgtC; pfam02308 1034836005932 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836005933 Helix-turn-helix domains; Region: HTH; cl00088 1034836005934 hypothetical protein; Provisional; Region: PRK09272 1034836005935 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1034836005936 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836005937 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034836005938 Helix-turn-helix domains; Region: HTH; cl00088 1034836005939 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836005940 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034836005941 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1034836005942 methionine cluster; other site 1034836005943 active site 1034836005944 phosphorylation site [posttranslational modification] 1034836005945 metal binding site [ion binding]; metal-binding site 1034836005946 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836005947 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1034836005948 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1034836005949 active site 1034836005950 P-loop; other site 1034836005951 phosphorylation site [posttranslational modification] 1034836005952 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1034836005953 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1034836005954 Helix-turn-helix domains; Region: HTH; cl00088 1034836005955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836005957 putative substrate translocation pore; other site 1034836005958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836005959 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034836005960 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1034836005961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836005962 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1034836005963 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1034836005964 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1034836005965 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1034836005966 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1034836005967 YolD-like protein; Region: YolD; pfam08863 1034836005968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836005969 Coenzyme A binding pocket [chemical binding]; other site 1034836005970 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836005971 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1034836005972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836005973 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836005974 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034836005975 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1034836005976 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836005977 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1034836005978 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836005979 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836005980 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1034836005981 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836005982 amidase catalytic site [active] 1034836005983 Zn binding residues [ion binding]; other site 1034836005984 substrate binding site [chemical binding]; other site 1034836005985 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836005986 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836005987 Phage lysis protein, holin; Region: Phage_holin; cl04675 1034836005988 Haemolysin XhlA; Region: XhlA; pfam10779 1034836005989 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1034836005990 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1034836005991 Baseplate J-like protein; Region: Baseplate_J; cl01294 1034836005992 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1034836005993 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836005994 Phage-related protein [Function unknown]; Region: COG5412 1034836005995 Phage-related protein [Function unknown]; Region: COG5412 1034836005996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1034836005997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034836005998 catalytic residue [active] 1034836005999 cell division protein FtsE; Provisional; Region: PRK10908 1034836006000 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1034836006001 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1034836006002 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1034836006003 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302 1034836006004 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1034836006005 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1034836006006 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1034836006007 Phage terminase large subunit; Region: Terminase_3; cl12054 1034836006008 Terminase-like family; Region: Terminase_6; pfam03237 1034836006009 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1034836006010 Helix-turn-helix domains; Region: HTH; cl00088 1034836006011 Helix-turn-helix domains; Region: HTH; cl00088 1034836006012 homoserine O-acetyltransferase; Provisional; Region: PRK08775 1034836006013 cyclase homology domain; Region: CHD; cd07302 1034836006014 nucleotidyl binding site; other site 1034836006015 metal binding site [ion binding]; metal-binding site 1034836006016 dimer interface [polypeptide binding]; other site 1034836006017 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1034836006018 Ligand Binding Site [chemical binding]; other site 1034836006019 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1034836006020 cell division protein ZipA; Provisional; Region: PRK01741 1034836006021 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1034836006022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836006023 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1034836006024 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1034836006025 Hypothetical protein Yqai; Region: Yqai; pfam09466 1034836006026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836006027 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836006028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836006029 non-specific DNA binding site [nucleotide binding]; other site 1034836006030 salt bridge; other site 1034836006031 sequence-specific DNA binding site [nucleotide binding]; other site 1034836006032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836006033 non-specific DNA binding site [nucleotide binding]; other site 1034836006034 salt bridge; other site 1034836006035 sequence-specific DNA binding site [nucleotide binding]; other site 1034836006036 Staphylococcal nuclease homologues; Region: SNc; smart00318 1034836006037 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1034836006038 Catalytic site; other site 1034836006039 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1034836006040 Domain of unknown function (DUF955); Region: DUF955; cl01076 1034836006041 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1034836006042 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1034836006043 Int/Topo IB signature motif; other site 1034836006044 cystathionine beta-lyase; Provisional; Region: PRK08064 1034836006045 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034836006046 homodimer interface [polypeptide binding]; other site 1034836006047 substrate-cofactor binding pocket; other site 1034836006048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836006049 catalytic residue [active] 1034836006050 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1034836006051 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034836006052 homodimer interface [polypeptide binding]; other site 1034836006053 substrate-cofactor binding pocket; other site 1034836006054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836006055 catalytic residue [active] 1034836006056 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836006057 Putative esterase; Region: Esterase; pfam00756 1034836006058 hypothetical protein; Provisional; Region: PRK13679 1034836006059 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1034836006060 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836006061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836006062 Coenzyme A binding pocket [chemical binding]; other site 1034836006063 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1034836006064 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034836006065 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 1034836006066 Walker A/P-loop; other site 1034836006067 ATP binding site [chemical binding]; other site 1034836006068 Q-loop/lid; other site 1034836006069 ABC transporter signature motif; other site 1034836006070 Walker B; other site 1034836006071 D-loop; other site 1034836006072 H-loop/switch region; other site 1034836006073 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836006074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836006075 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1034836006076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836006077 Family description; Region: UvrD_C_2; cl15862 1034836006078 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1034836006079 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1034836006080 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1034836006081 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1034836006082 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1034836006083 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1034836006084 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1034836006085 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1034836006086 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1034836006087 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1034836006088 NAD binding site [chemical binding]; other site 1034836006089 homotetramer interface [polypeptide binding]; other site 1034836006090 homodimer interface [polypeptide binding]; other site 1034836006091 substrate binding site [chemical binding]; other site 1034836006092 active site 1034836006093 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1034836006094 dimer interface [polypeptide binding]; other site 1034836006095 substrate binding site [chemical binding]; other site 1034836006096 ATP binding site [chemical binding]; other site 1034836006097 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1034836006098 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1034836006099 ATP binding site [chemical binding]; other site 1034836006100 substrate interface [chemical binding]; other site 1034836006101 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1034836006102 ThiS interaction site; other site 1034836006103 putative active site [active] 1034836006104 tetramer interface [polypeptide binding]; other site 1034836006105 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1034836006106 thiS-thiF/thiG interaction site; other site 1034836006107 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1034836006108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006109 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1034836006110 thiamine phosphate binding site [chemical binding]; other site 1034836006111 active site 1034836006112 pyrophosphate binding site [ion binding]; other site 1034836006113 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1034836006114 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1034836006115 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1034836006116 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1034836006117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006118 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836006119 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1034836006120 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1034836006121 active site 1034836006122 metal binding site [ion binding]; metal-binding site 1034836006123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1034836006124 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034836006125 active site 1034836006126 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1034836006127 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034836006128 synthetase active site [active] 1034836006129 NTP binding site [chemical binding]; other site 1034836006130 metal binding site [ion binding]; metal-binding site 1034836006131 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1034836006132 putative active site [active] 1034836006133 putative metal binding residues [ion binding]; other site 1034836006134 signature motif; other site 1034836006135 putative triphosphate binding site [ion binding]; other site 1034836006136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1034836006137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034836006138 catalytic residue [active] 1034836006139 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1034836006140 apolar tunnel; other site 1034836006141 heme binding site [chemical binding]; other site 1034836006142 dimerization interface [polypeptide binding]; other site 1034836006143 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1034836006144 Thioredoxin; Region: Thioredoxin_5; pfam13743 1034836006145 catalytic residues [active] 1034836006146 oligoendopeptidase F; Region: pepF; TIGR00181 1034836006147 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1034836006148 active site 1034836006149 Zn binding site [ion binding]; other site 1034836006150 Competence protein CoiA-like family; Region: CoiA; cl11541 1034836006151 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1034836006152 Integral membrane protein TerC family; Region: TerC; cl10468 1034836006153 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1034836006154 ArsC family; Region: ArsC; pfam03960 1034836006155 putative catalytic residues [active] 1034836006156 thiol/disulfide switch; other site 1034836006157 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836006158 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1034836006159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034836006160 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836006161 Walker A/P-loop; other site 1034836006162 ATP binding site [chemical binding]; other site 1034836006163 Q-loop/lid; other site 1034836006164 ABC transporter signature motif; other site 1034836006165 Walker B; other site 1034836006166 D-loop; other site 1034836006167 H-loop/switch region; other site 1034836006168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836006169 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034836006170 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836006171 Walker A/P-loop; other site 1034836006172 ATP binding site [chemical binding]; other site 1034836006173 Q-loop/lid; other site 1034836006174 ABC transporter signature motif; other site 1034836006175 Walker B; other site 1034836006176 D-loop; other site 1034836006177 H-loop/switch region; other site 1034836006178 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836006179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1034836006180 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1034836006181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006182 dimer interface [polypeptide binding]; other site 1034836006183 conserved gate region; other site 1034836006184 putative PBP binding loops; other site 1034836006185 ABC-ATPase subunit interface; other site 1034836006186 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1034836006187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006188 dimer interface [polypeptide binding]; other site 1034836006189 conserved gate region; other site 1034836006190 putative PBP binding loops; other site 1034836006191 ABC-ATPase subunit interface; other site 1034836006192 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1034836006193 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1034836006194 peptide binding site [polypeptide binding]; other site 1034836006195 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1034836006196 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1034836006197 active site 1034836006198 HIGH motif; other site 1034836006199 dimer interface [polypeptide binding]; other site 1034836006200 KMSKS motif; other site 1034836006201 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1034836006202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1034836006203 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1034836006204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006205 dimer interface [polypeptide binding]; other site 1034836006206 conserved gate region; other site 1034836006207 putative PBP binding loops; other site 1034836006208 ABC-ATPase subunit interface; other site 1034836006209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034836006210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006211 dimer interface [polypeptide binding]; other site 1034836006212 conserved gate region; other site 1034836006213 putative PBP binding loops; other site 1034836006214 ABC-ATPase subunit interface; other site 1034836006215 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1034836006216 peptide binding site [polypeptide binding]; other site 1034836006217 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1034836006218 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1034836006219 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836006220 Walker A/P-loop; other site 1034836006221 ATP binding site [chemical binding]; other site 1034836006222 Q-loop/lid; other site 1034836006223 ABC transporter signature motif; other site 1034836006224 Walker B; other site 1034836006225 D-loop; other site 1034836006226 H-loop/switch region; other site 1034836006227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836006228 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034836006229 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1034836006230 Walker A/P-loop; other site 1034836006231 ATP binding site [chemical binding]; other site 1034836006232 Q-loop/lid; other site 1034836006233 ABC transporter signature motif; other site 1034836006234 Walker B; other site 1034836006235 D-loop; other site 1034836006236 H-loop/switch region; other site 1034836006237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034836006238 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1034836006239 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1034836006240 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1034836006241 dimer interface [polypeptide binding]; other site 1034836006242 active site 1034836006243 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1034836006244 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1034836006245 dimer interface [polypeptide binding]; other site 1034836006246 active site 1034836006247 CoA binding pocket [chemical binding]; other site 1034836006248 ComZ; Region: ComZ; pfam10815 1034836006249 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1034836006250 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1034836006251 putative ligand binding site [chemical binding]; other site 1034836006252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006253 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1034836006254 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1034836006255 YjzC-like protein; Region: YjzC; pfam14168 1034836006256 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1034836006257 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1034836006258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006259 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1034836006260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836006261 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836006262 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1034836006263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836006264 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836006265 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1034836006266 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1034836006267 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1034836006268 catalytic site [active] 1034836006269 subunit interface [polypeptide binding]; other site 1034836006270 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1034836006271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836006272 inhibitor-cofactor binding pocket; inhibition site 1034836006273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836006274 catalytic residue [active] 1034836006275 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1034836006276 nucleotide binding site [chemical binding]; other site 1034836006277 N-acetyl-L-glutamate binding site [chemical binding]; other site 1034836006278 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1034836006279 heterotetramer interface [polypeptide binding]; other site 1034836006280 active site pocket [active] 1034836006281 cleavage site 1034836006282 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1034836006283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006284 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1034836006285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836006286 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1034836006287 Sulfatase; Region: Sulfatase; cl10460 1034836006288 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1034836006289 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1034836006290 active site 1034836006291 Int/Topo IB signature motif; other site 1034836006292 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1034836006293 ferric uptake regulator; Provisional; Region: fur; PRK09462 1034836006294 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034836006295 metal binding site 2 [ion binding]; metal-binding site 1034836006296 putative DNA binding helix; other site 1034836006297 metal binding site 1 [ion binding]; metal-binding site 1034836006298 dimer interface [polypeptide binding]; other site 1034836006299 structural Zn2+ binding site [ion binding]; other site 1034836006300 Integral membrane protein DUF95; Region: DUF95; cl00572 1034836006301 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1034836006302 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1034836006303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006304 NAD(P) binding pocket [chemical binding]; other site 1034836006305 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1034836006306 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1034836006307 Aspartase; Region: Aspartase; cd01357 1034836006308 active sites [active] 1034836006309 tetramer interface [polypeptide binding]; other site 1034836006310 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1034836006311 active site 1034836006312 homodimer interface [polypeptide binding]; other site 1034836006313 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034836006314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836006315 non-specific DNA binding site [nucleotide binding]; other site 1034836006316 salt bridge; other site 1034836006317 sequence-specific DNA binding site [nucleotide binding]; other site 1034836006318 TIGR00375 family protein; Region: TIGR00375 1034836006319 PHP-associated; Region: PHP_C; pfam13263 1034836006320 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1034836006321 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1034836006322 dimer interface [polypeptide binding]; other site 1034836006323 ADP-ribose binding site [chemical binding]; other site 1034836006324 active site 1034836006325 nudix motif; other site 1034836006326 metal binding site [ion binding]; metal-binding site 1034836006327 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1034836006328 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1034836006329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836006330 active site 1034836006331 catalytic tetrad [active] 1034836006332 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1034836006333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836006334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836006335 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1034836006336 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1034836006337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1034836006338 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836006339 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1034836006340 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1034836006341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836006342 Coenzyme A binding pocket [chemical binding]; other site 1034836006343 DNA polymerase IV; Reviewed; Region: PRK03103 1034836006344 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1034836006345 active site 1034836006346 DNA binding site [nucleotide binding] 1034836006347 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1034836006348 YolD-like protein; Region: YolD; pfam08863 1034836006349 YqzH-like protein; Region: YqzH; pfam14164 1034836006350 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034836006351 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836006352 pantothenate kinase; Provisional; Region: PRK05439 1034836006353 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1034836006354 ATP-binding site [chemical binding]; other site 1034836006355 CoA-binding site [chemical binding]; other site 1034836006356 Mg2+-binding site [ion binding]; other site 1034836006357 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1034836006358 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1034836006359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836006360 catalytic residue [active] 1034836006361 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1034836006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006363 NAD(P) binding site [chemical binding]; other site 1034836006364 active site 1034836006365 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836006366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006367 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1034836006368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836006369 Helix-turn-helix domains; Region: HTH; cl00088 1034836006370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836006371 dimerization interface [polypeptide binding]; other site 1034836006372 GlpM protein; Region: GlpM; cl01212 1034836006373 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1034836006374 active site 1034836006375 FMN binding site [chemical binding]; other site 1034836006376 substrate binding site [chemical binding]; other site 1034836006377 homotetramer interface [polypeptide binding]; other site 1034836006378 catalytic residue [active] 1034836006379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1034836006380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836006381 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1034836006382 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1034836006383 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1034836006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006385 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1034836006386 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1034836006387 DNA polymerase IV; Validated; Region: PRK01810 1034836006388 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1034836006389 active site 1034836006390 DNA binding site [nucleotide binding] 1034836006391 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1034836006392 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1034836006393 potential frameshift: common BLAST hit: gi|154686652|ref|YP_001421813.1| YqjE 1034836006394 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1034836006395 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836006396 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836006397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836006398 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1034836006399 dimer interface [polypeptide binding]; other site 1034836006400 substrate binding site [chemical binding]; other site 1034836006401 metal binding site [ion binding]; metal-binding site 1034836006402 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1034836006403 Predicted membrane protein [Function unknown]; Region: COG4129 1034836006404 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1034836006405 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1034836006406 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034836006407 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1034836006408 Walker A/P-loop; other site 1034836006409 ATP binding site [chemical binding]; other site 1034836006410 Q-loop/lid; other site 1034836006411 ABC transporter signature motif; other site 1034836006412 Walker B; other site 1034836006413 D-loop; other site 1034836006414 H-loop/switch region; other site 1034836006415 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034836006416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006417 dimer interface [polypeptide binding]; other site 1034836006418 conserved gate region; other site 1034836006419 putative PBP binding loops; other site 1034836006420 ABC-ATPase subunit interface; other site 1034836006421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836006422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034836006423 substrate binding pocket [chemical binding]; other site 1034836006424 membrane-bound complex binding site; other site 1034836006425 hinge residues; other site 1034836006426 Disulphide isomerase; Region: Disulph_isomer; cl05813 1034836006427 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1034836006428 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1034836006429 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034836006430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034836006431 E3 interaction surface; other site 1034836006432 lipoyl attachment site [posttranslational modification]; other site 1034836006433 e3 binding domain; Region: E3_binding; pfam02817 1034836006434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1034836006435 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034836006436 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034836006437 alpha subunit interface [polypeptide binding]; other site 1034836006438 TPP binding site [chemical binding]; other site 1034836006439 heterodimer interface [polypeptide binding]; other site 1034836006440 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034836006441 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1034836006442 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034836006443 tetramer interface [polypeptide binding]; other site 1034836006444 TPP-binding site [chemical binding]; other site 1034836006445 heterodimer interface [polypeptide binding]; other site 1034836006446 phosphorylation loop region [posttranslational modification] 1034836006447 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1034836006448 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 1034836006449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836006450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034836006451 Acetokinase family; Region: Acetate_kinase; cl01029 1034836006452 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1034836006453 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1034836006454 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1034836006455 NAD binding site [chemical binding]; other site 1034836006456 Phe binding site; other site 1034836006457 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1034836006458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006459 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1034836006460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034836006461 putative active site [active] 1034836006462 heme pocket [chemical binding]; other site 1034836006463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836006464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836006465 Walker A motif; other site 1034836006466 ATP binding site [chemical binding]; other site 1034836006467 Walker B motif; other site 1034836006468 arginine finger; other site 1034836006469 Helix-turn-helix domains; Region: HTH; cl00088 1034836006470 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1034836006471 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1034836006472 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1034836006473 tetramer interface [polypeptide binding]; other site 1034836006474 active site 1034836006475 Mg2+/Mn2+ binding site [ion binding]; other site 1034836006476 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1034836006477 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1034836006478 dimer interface [polypeptide binding]; other site 1034836006479 Citrate synthase; Region: Citrate_synt; pfam00285 1034836006480 active site 1034836006481 coenzyme A binding site [chemical binding]; other site 1034836006482 citrylCoA binding site [chemical binding]; other site 1034836006483 oxalacetate/citrate binding site [chemical binding]; other site 1034836006484 catalytic triad [active] 1034836006485 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1034836006486 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1034836006487 FAD binding site [chemical binding]; other site 1034836006488 homotetramer interface [polypeptide binding]; other site 1034836006489 substrate binding pocket [chemical binding]; other site 1034836006490 catalytic base [active] 1034836006491 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1034836006492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006493 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1034836006494 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1034836006495 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1034836006496 dimer interface [polypeptide binding]; other site 1034836006497 active site 1034836006498 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1034836006499 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1034836006500 active site 1034836006501 catalytic site [active] 1034836006502 metal binding site [ion binding]; metal-binding site 1034836006503 dimer interface [polypeptide binding]; other site 1034836006504 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034836006505 active site 1034836006506 metal binding site [ion binding]; metal-binding site 1034836006507 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1034836006508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836006509 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1034836006510 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1034836006511 putative active site [active] 1034836006512 putative FMN binding site [chemical binding]; other site 1034836006513 putative substrate binding site [chemical binding]; other site 1034836006514 putative catalytic residue [active] 1034836006515 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836006516 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836006517 alanine racemase; Region: alr; TIGR00492 1034836006518 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1034836006519 active site 1034836006520 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034836006521 dimer interface [polypeptide binding]; other site 1034836006522 substrate binding site [chemical binding]; other site 1034836006523 catalytic residues [active] 1034836006524 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1034836006525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836006526 active site 1034836006527 phosphorylation site [posttranslational modification] 1034836006528 intermolecular recognition site; other site 1034836006529 dimerization interface [polypeptide binding]; other site 1034836006530 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1034836006531 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1034836006532 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1034836006533 protein binding site [polypeptide binding]; other site 1034836006534 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1034836006535 DNA repair protein RecN; Region: recN; TIGR00634 1034836006536 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1034836006537 Walker A/P-loop; other site 1034836006538 ATP binding site [chemical binding]; other site 1034836006539 Q-loop/lid; other site 1034836006540 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1034836006541 ABC transporter signature motif; other site 1034836006542 Walker B; other site 1034836006543 D-loop; other site 1034836006544 H-loop/switch region; other site 1034836006545 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1034836006546 arginine repressor; Provisional; Region: PRK04280 1034836006547 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1034836006548 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1034836006549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836006550 RNA binding surface [nucleotide binding]; other site 1034836006551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836006552 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1034836006553 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1034836006554 TPP-binding site; other site 1034836006555 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1034836006556 PYR/PP interface [polypeptide binding]; other site 1034836006557 dimer interface [polypeptide binding]; other site 1034836006558 TPP binding site [chemical binding]; other site 1034836006559 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034836006560 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1034836006561 substrate binding pocket [chemical binding]; other site 1034836006562 chain length determination region; other site 1034836006563 substrate-Mg2+ binding site; other site 1034836006564 catalytic residues [active] 1034836006565 aspartate-rich region 1; other site 1034836006566 active site lid residues [active] 1034836006567 aspartate-rich region 2; other site 1034836006568 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1034836006569 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1034836006570 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1034836006571 generic binding surface II; other site 1034836006572 generic binding surface I; other site 1034836006573 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1034836006574 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1034836006575 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1034836006576 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1034836006577 homodimer interface [polypeptide binding]; other site 1034836006578 NADP binding site [chemical binding]; other site 1034836006579 substrate binding site [chemical binding]; other site 1034836006580 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1034836006581 putative RNA binding site [nucleotide binding]; other site 1034836006582 Asp23 family; Region: Asp23; cl00574 1034836006583 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1034836006584 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034836006585 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1034836006586 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1034836006587 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034836006588 carboxyltransferase (CT) interaction site; other site 1034836006589 biotinylation site [posttranslational modification]; other site 1034836006590 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1034836006591 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1034836006592 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 1034836006593 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1034836006594 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1034836006595 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1034836006596 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1034836006597 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1034836006598 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1034836006599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836006600 Walker A motif; other site 1034836006601 ATP binding site [chemical binding]; other site 1034836006602 Walker B motif; other site 1034836006603 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1034836006604 elongation factor P; Validated; Region: PRK00529 1034836006605 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1034836006606 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1034836006607 RNA binding site [nucleotide binding]; other site 1034836006608 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1034836006609 RNA binding site [nucleotide binding]; other site 1034836006610 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1034836006611 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1034836006612 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1034836006613 active site 1034836006614 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1034836006615 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1034836006616 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1034836006617 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1034836006618 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1034836006619 active site 1034836006620 nucleophile elbow; other site 1034836006621 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1034836006622 Helix-turn-helix domains; Region: HTH; cl00088 1034836006623 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1034836006624 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034836006625 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1034836006626 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1034836006627 active site residue [active] 1034836006628 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1034836006629 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1034836006630 tetramer interface [polypeptide binding]; other site 1034836006631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836006632 catalytic residue [active] 1034836006633 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1034836006634 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1034836006635 tetramer interface [polypeptide binding]; other site 1034836006636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836006637 catalytic residue [active] 1034836006638 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1034836006639 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1034836006640 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1034836006641 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1034836006642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836006643 ATP binding site [chemical binding]; other site 1034836006644 putative Mg++ binding site [ion binding]; other site 1034836006645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836006646 nucleotide binding region [chemical binding]; other site 1034836006647 ATP-binding site [chemical binding]; other site 1034836006648 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1034836006649 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1034836006650 Anti-repressor SinI; Region: SinI; pfam08671 1034836006651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836006652 non-specific DNA binding site [nucleotide binding]; other site 1034836006653 salt bridge; other site 1034836006654 sequence-specific DNA binding site [nucleotide binding]; other site 1034836006655 Anti-repressor SinI; Region: SinI; pfam08671 1034836006656 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1034836006657 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1034836006658 Catalytic site [active] 1034836006659 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1034836006660 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1034836006661 YqzE-like protein; Region: YqzE; pfam14038 1034836006662 ComG operon protein 7; Region: ComGG; pfam14173 1034836006663 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1034836006664 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1034836006665 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1034836006666 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1034836006667 Type II/IV secretion system protein; Region: T2SE; pfam00437 1034836006668 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1034836006669 Walker A motif; other site 1034836006670 ATP binding site [chemical binding]; other site 1034836006671 Walker B motif; other site 1034836006672 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1034836006673 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1034836006674 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1034836006675 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034836006676 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034836006677 Transporter associated domain; Region: CorC_HlyC; cl08393 1034836006678 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836006679 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1034836006680 ArsC family; Region: ArsC; pfam03960 1034836006681 putative catalytic residues [active] 1034836006682 thiol/disulfide switch; other site 1034836006683 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1034836006684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836006685 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1034836006686 Domain of unknown function DUF77; Region: DUF77; cl00307 1034836006687 potential frameshift: common BLAST hit: gi|154686745|ref|YP_001421906.1| YqgU 1034836006688 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1034836006689 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1034836006690 putative active site [active] 1034836006691 Zn binding site [ion binding]; other site 1034836006692 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1034836006693 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1034836006694 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 1034836006695 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1034836006696 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1034836006697 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1034836006698 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1034836006699 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1034836006700 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1034836006701 Walker A/P-loop; other site 1034836006702 ATP binding site [chemical binding]; other site 1034836006703 Q-loop/lid; other site 1034836006704 ABC transporter signature motif; other site 1034836006705 Walker B; other site 1034836006706 D-loop; other site 1034836006707 H-loop/switch region; other site 1034836006708 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1034836006709 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1034836006710 Walker A/P-loop; other site 1034836006711 ATP binding site [chemical binding]; other site 1034836006712 Q-loop/lid; other site 1034836006713 ABC transporter signature motif; other site 1034836006714 Walker B; other site 1034836006715 D-loop; other site 1034836006716 H-loop/switch region; other site 1034836006717 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1034836006718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006719 dimer interface [polypeptide binding]; other site 1034836006720 conserved gate region; other site 1034836006721 ABC-ATPase subunit interface; other site 1034836006722 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1034836006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836006724 dimer interface [polypeptide binding]; other site 1034836006725 conserved gate region; other site 1034836006726 putative PBP binding loops; other site 1034836006727 ABC-ATPase subunit interface; other site 1034836006728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836006729 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1034836006730 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034836006731 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836006732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836006733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836006734 putative substrate translocation pore; other site 1034836006735 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1034836006736 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1034836006737 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1034836006738 Protein of unknown function (DUF456); Region: DUF456; cl01069 1034836006739 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1034836006740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1034836006741 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1034836006742 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1034836006743 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1034836006744 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836006745 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034836006746 metal binding site 2 [ion binding]; metal-binding site 1034836006747 putative DNA binding helix; other site 1034836006748 metal binding site 1 [ion binding]; metal-binding site 1034836006749 dimer interface [polypeptide binding]; other site 1034836006750 structural Zn2+ binding site [ion binding]; other site 1034836006751 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836006752 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836006753 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836006754 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836006755 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1034836006756 endonuclease IV; Provisional; Region: PRK01060 1034836006757 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1034836006758 AP (apurinic/apyrimidinic) site pocket; other site 1034836006759 DNA interaction; other site 1034836006760 Metal-binding active site; metal-binding site 1034836006761 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034836006762 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1034836006763 ATP binding site [chemical binding]; other site 1034836006764 Mg++ binding site [ion binding]; other site 1034836006765 motif III; other site 1034836006766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836006767 nucleotide binding region [chemical binding]; other site 1034836006768 ATP-binding site [chemical binding]; other site 1034836006769 YqfQ-like protein; Region: YqfQ; pfam14181 1034836006770 LytB protein; Region: LYTB; cl00507 1034836006771 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1034836006772 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1034836006773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1034836006774 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1034836006775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836006776 Cytochrome c; Region: Cytochrom_C; cl11414 1034836006777 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1034836006778 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1034836006779 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1034836006780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836006781 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034836006782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836006783 DNA binding residues [nucleotide binding] 1034836006784 DNA primase; Validated; Region: dnaG; PRK05667 1034836006785 CHC2 zinc finger; Region: zf-CHC2; cl15369 1034836006786 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1034836006787 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1034836006788 active site 1034836006789 metal binding site [ion binding]; metal-binding site 1034836006790 interdomain interaction site; other site 1034836006791 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1034836006792 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1034836006793 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1034836006794 Helix-turn-helix domains; Region: HTH; cl00088 1034836006795 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1034836006796 FOG: CBS domain [General function prediction only]; Region: COG0517 1034836006797 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1034836006798 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1034836006799 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1034836006800 dimer interface [polypeptide binding]; other site 1034836006801 motif 1; other site 1034836006802 active site 1034836006803 motif 2; other site 1034836006804 motif 3; other site 1034836006805 Recombination protein O N terminal; Region: RecO_N; cl15812 1034836006806 DNA repair protein RecO; Region: reco; TIGR00613 1034836006807 Recombination protein O C terminal; Region: RecO_C; pfam02565 1034836006808 YqzL-like protein; Region: YqzL; pfam14006 1034836006809 GTPase Era; Reviewed; Region: era; PRK00089 1034836006810 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1034836006811 G1 box; other site 1034836006812 GTP/Mg2+ binding site [chemical binding]; other site 1034836006813 Switch I region; other site 1034836006814 G2 box; other site 1034836006815 Switch II region; other site 1034836006816 G3 box; other site 1034836006817 G4 box; other site 1034836006818 G5 box; other site 1034836006819 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1034836006820 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1034836006821 active site 1034836006822 catalytic motif [active] 1034836006823 Zn binding site [ion binding]; other site 1034836006824 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1034836006825 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1034836006826 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1034836006827 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1034836006828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034836006829 Zn2+ binding site [ion binding]; other site 1034836006830 Mg2+ binding site [ion binding]; other site 1034836006831 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1034836006832 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836006833 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1034836006834 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1034836006835 YabP family; Region: YabP; cl06766 1034836006836 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1034836006837 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1034836006838 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1034836006839 dimer interface [polypeptide binding]; other site 1034836006840 active site residues [active] 1034836006841 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1034836006842 GatB domain; Region: GatB_Yqey; cl11497 1034836006843 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1034836006844 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1034836006845 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1034836006846 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1034836006847 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 1034836006848 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1034836006849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836006850 FeS/SAM binding site; other site 1034836006851 TRAM domain; Region: TRAM; cl01282 1034836006852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1034836006853 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1034836006854 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1034836006855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836006856 S-adenosylmethionine binding site [chemical binding]; other site 1034836006857 chaperone protein DnaJ; Provisional; Region: PRK14280 1034836006858 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1034836006859 HSP70 interaction site [polypeptide binding]; other site 1034836006860 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1034836006861 substrate binding site [polypeptide binding]; other site 1034836006862 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1034836006863 Zn binding sites [ion binding]; other site 1034836006864 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1034836006865 dimer interface [polypeptide binding]; other site 1034836006866 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1034836006867 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1034836006868 dimer interface [polypeptide binding]; other site 1034836006869 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1034836006870 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1034836006871 Helix-turn-helix domains; Region: HTH; cl00088 1034836006872 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1034836006873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836006874 FeS/SAM binding site; other site 1034836006875 HemN C-terminal domain; Region: HemN_C; pfam06969 1034836006876 GTP-binding protein LepA; Provisional; Region: PRK05433 1034836006877 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1034836006878 G1 box; other site 1034836006879 putative GEF interaction site [polypeptide binding]; other site 1034836006880 GTP/Mg2+ binding site [chemical binding]; other site 1034836006881 Switch I region; other site 1034836006882 G2 box; other site 1034836006883 G3 box; other site 1034836006884 Switch II region; other site 1034836006885 G4 box; other site 1034836006886 G5 box; other site 1034836006887 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1034836006888 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1034836006889 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1034836006890 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1034836006891 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1034836006892 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1034836006893 Germination protease; Region: Peptidase_A25; cl04057 1034836006894 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1034836006895 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1034836006896 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1034836006897 YqzM-like protein; Region: YqzM; pfam14141 1034836006898 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1034836006899 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1034836006900 Competence protein; Region: Competence; cl00471 1034836006901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836006902 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1034836006903 catalytic motif [active] 1034836006904 Zn binding site [ion binding]; other site 1034836006905 SLBB domain; Region: SLBB; pfam10531 1034836006906 comEA protein; Region: comE; TIGR01259 1034836006907 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1034836006908 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1034836006909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836006910 NAD(P) binding pocket [chemical binding]; other site 1034836006911 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1034836006912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836006913 S-adenosylmethionine binding site [chemical binding]; other site 1034836006914 Oligomerisation domain; Region: Oligomerisation; cl00519 1034836006915 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1034836006916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034836006917 Zn2+ binding site [ion binding]; other site 1034836006918 Mg2+ binding site [ion binding]; other site 1034836006919 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1034836006920 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1034836006921 active site 1034836006922 (T/H)XGH motif; other site 1034836006923 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1034836006924 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1034836006925 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1034836006926 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1034836006927 shikimate binding site; other site 1034836006928 NAD(P) binding site [chemical binding]; other site 1034836006929 GTPase YqeH; Provisional; Region: PRK13796 1034836006930 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1034836006931 GTP/Mg2+ binding site [chemical binding]; other site 1034836006932 G4 box; other site 1034836006933 G5 box; other site 1034836006934 G1 box; other site 1034836006935 Switch I region; other site 1034836006936 G2 box; other site 1034836006937 G3 box; other site 1034836006938 Switch II region; other site 1034836006939 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1034836006940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836006941 active site 1034836006942 motif I; other site 1034836006943 motif II; other site 1034836006944 Sporulation inhibitor A; Region: Sda; pfam08970 1034836006945 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1034836006946 active site 1034836006947 catalytic triad [active] 1034836006948 oxyanion hole [active] 1034836006949 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1034836006950 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1034836006951 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836006952 amidase catalytic site [active] 1034836006953 Zn binding residues [ion binding]; other site 1034836006954 substrate binding site [chemical binding]; other site 1034836006955 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836006956 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836006957 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836006959 putative substrate translocation pore; other site 1034836006960 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1034836006961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034836006962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836006963 DNA binding residues [nucleotide binding] 1034836006964 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1034836006965 Helix-turn-helix domains; Region: HTH; cl00088 1034836006966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836006967 DNA binding residues [nucleotide binding] 1034836006968 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836006969 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1034836006970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836006971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836006972 putative substrate translocation pore; other site 1034836006973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836006974 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836006975 DinB superfamily; Region: DinB_2; pfam12867 1034836006976 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836006977 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836006978 active site 1034836006979 motif I; other site 1034836006980 motif II; other site 1034836006981 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836006982 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836006983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836006984 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836006985 active site 1034836006986 motif I; other site 1034836006987 motif II; other site 1034836006988 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836006989 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034836006990 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034836006991 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034836006992 putative active site [active] 1034836006993 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1034836006994 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1034836006995 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1034836006996 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1034836006997 active site 1034836006998 P-loop; other site 1034836006999 phosphorylation site [posttranslational modification] 1034836007000 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836007001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034836007002 active site 1034836007003 phosphorylation site [posttranslational modification] 1034836007004 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034836007005 Helix-turn-helix domains; Region: HTH; cl00088 1034836007006 Helix-turn-helix domains; Region: HTH; cl00088 1034836007007 PRD domain; Region: PRD; cl15445 1034836007008 PRD domain; Region: PRD; cl15445 1034836007009 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034836007010 active site 1034836007011 P-loop; other site 1034836007012 phosphorylation site [posttranslational modification] 1034836007013 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034836007014 active site 1034836007015 phosphorylation site [posttranslational modification] 1034836007016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836007017 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1034836007018 putative deacylase active site [active] 1034836007019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836007020 Helix-turn-helix domains; Region: HTH; cl00088 1034836007021 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1034836007022 putative dimerization interface [polypeptide binding]; other site 1034836007023 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836007024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836007025 putative substrate translocation pore; other site 1034836007026 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1034836007027 Cytochrome P450; Region: p450; pfam00067 1034836007028 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1034836007029 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836007030 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1034836007031 FAD binding pocket [chemical binding]; other site 1034836007032 FAD binding motif [chemical binding]; other site 1034836007033 catalytic residues [active] 1034836007034 NAD binding pocket [chemical binding]; other site 1034836007035 phosphate binding motif [ion binding]; other site 1034836007036 beta-alpha-beta structure motif; other site 1034836007037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836007038 Helix-turn-helix domains; Region: HTH; cl00088 1034836007039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836007040 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1034836007041 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1034836007042 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1034836007043 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1034836007044 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1034836007045 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1034836007046 4Fe-4S binding domain; Region: Fer4; cl02805 1034836007047 4Fe-4S binding domain; Region: Fer4; cl02805 1034836007048 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1034836007049 [4Fe-4S] binding site [ion binding]; other site 1034836007050 molybdopterin cofactor binding site; other site 1034836007051 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1034836007052 molybdopterin cofactor binding site; other site 1034836007053 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1034836007054 YrhC-like protein; Region: YrhC; pfam14143 1034836007055 cystathionine beta-lyase; Provisional; Region: PRK07671 1034836007056 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034836007057 homodimer interface [polypeptide binding]; other site 1034836007058 substrate-cofactor binding pocket; other site 1034836007059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836007060 catalytic residue [active] 1034836007061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1034836007062 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1034836007063 dimer interface [polypeptide binding]; other site 1034836007064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836007065 catalytic residue [active] 1034836007066 5'-methylthioadenosine nucleosidase; Region: PLN02584 1034836007067 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1034836007068 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1034836007069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836007070 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1034836007071 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1034836007072 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034836007073 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034836007074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836007075 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1034836007076 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1034836007077 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1034836007078 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1034836007079 Sugar specificity; other site 1034836007080 Pyrimidine base specificity; other site 1034836007081 ATP-binding site [chemical binding]; other site 1034836007082 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1034836007083 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1034836007084 Peptidase family U32; Region: Peptidase_U32; cl03113 1034836007085 Peptidase family U32; Region: Peptidase_U32; cl03113 1034836007086 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1034836007087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836007088 S-adenosylmethionine binding site [chemical binding]; other site 1034836007089 YceG-like family; Region: YceG; pfam02618 1034836007090 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1034836007091 dimerization interface [polypeptide binding]; other site 1034836007092 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1034836007093 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1034836007094 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 1034836007095 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1034836007096 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1034836007097 motif 1; other site 1034836007098 active site 1034836007099 motif 2; other site 1034836007100 motif 3; other site 1034836007101 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1034836007102 DHHA1 domain; Region: DHHA1; pfam02272 1034836007103 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836007104 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034836007105 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034836007106 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1034836007107 Walker A/P-loop; other site 1034836007108 ATP binding site [chemical binding]; other site 1034836007109 Q-loop/lid; other site 1034836007110 ABC transporter signature motif; other site 1034836007111 Walker B; other site 1034836007112 D-loop; other site 1034836007113 H-loop/switch region; other site 1034836007114 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034836007115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836007116 substrate binding pocket [chemical binding]; other site 1034836007117 membrane-bound complex binding site; other site 1034836007118 hinge residues; other site 1034836007119 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034836007120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007121 dimer interface [polypeptide binding]; other site 1034836007122 conserved gate region; other site 1034836007123 putative PBP binding loops; other site 1034836007124 ABC-ATPase subunit interface; other site 1034836007125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1034836007126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007127 dimer interface [polypeptide binding]; other site 1034836007128 ABC-ATPase subunit interface; other site 1034836007129 putative PBP binding loops; other site 1034836007130 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1034836007131 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1034836007132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836007133 Family description; Region: UvrD_C_2; cl15862 1034836007134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836007135 binding surface 1034836007136 TPR motif; other site 1034836007137 TPR repeat; Region: TPR_11; pfam13414 1034836007138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836007139 binding surface 1034836007140 TPR motif; other site 1034836007141 TPR repeat; Region: TPR_11; pfam13414 1034836007142 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1034836007143 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1034836007144 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836007145 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1034836007146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836007147 catalytic residue [active] 1034836007148 Predicted transcriptional regulator [Transcription]; Region: COG1959 1034836007149 Helix-turn-helix domains; Region: HTH; cl00088 1034836007150 recombination factor protein RarA; Reviewed; Region: PRK13342 1034836007151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007152 Walker A motif; other site 1034836007153 ATP binding site [chemical binding]; other site 1034836007154 Walker B motif; other site 1034836007155 arginine finger; other site 1034836007156 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1034836007157 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1034836007158 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1034836007159 putative ATP binding site [chemical binding]; other site 1034836007160 putative substrate interface [chemical binding]; other site 1034836007161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1034836007162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1034836007163 dimer interface [polypeptide binding]; other site 1034836007164 anticodon binding site; other site 1034836007165 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1034836007166 homodimer interface [polypeptide binding]; other site 1034836007167 motif 1; other site 1034836007168 active site 1034836007169 motif 2; other site 1034836007170 GAD domain; Region: GAD; pfam02938 1034836007171 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1034836007172 active site 1034836007173 motif 3; other site 1034836007174 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1034836007175 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1034836007176 dimer interface [polypeptide binding]; other site 1034836007177 motif 1; other site 1034836007178 active site 1034836007179 motif 2; other site 1034836007180 motif 3; other site 1034836007181 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1034836007182 anticodon binding site; other site 1034836007183 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1034836007184 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836007185 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836007186 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836007187 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836007188 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034836007189 active site 1034836007190 metal binding site [ion binding]; metal-binding site 1034836007191 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1034836007192 putative active site [active] 1034836007193 dimerization interface [polypeptide binding]; other site 1034836007194 putative tRNAtyr binding site [nucleotide binding]; other site 1034836007195 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1034836007196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1034836007197 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034836007198 synthetase active site [active] 1034836007199 NTP binding site [chemical binding]; other site 1034836007200 metal binding site [ion binding]; metal-binding site 1034836007201 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1034836007202 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1034836007203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836007204 active site 1034836007205 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1034836007206 DHH family; Region: DHH; pfam01368 1034836007207 DHHA1 domain; Region: DHHA1; pfam02272 1034836007208 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1034836007209 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1034836007210 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1034836007211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836007212 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1034836007213 Protein export membrane protein; Region: SecD_SecF; cl14618 1034836007214 Protein export membrane protein; Region: SecD_SecF; cl14618 1034836007215 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1034836007216 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1034836007217 MatE; Region: MatE; cl10513 1034836007218 Protein of unknown function (DUF421); Region: DUF421; cl00990 1034836007219 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1034836007220 Preprotein translocase subunit; Region: YajC; cl00806 1034836007221 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1034836007222 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 1034836007223 potential frameshift: common BLAST hit: gi|154686913|ref|YP_001422074.1| S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1034836007224 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1034836007225 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1034836007226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007227 Walker A motif; other site 1034836007228 ATP binding site [chemical binding]; other site 1034836007229 Walker B motif; other site 1034836007230 arginine finger; other site 1034836007231 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1034836007232 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1034836007233 RuvA N terminal domain; Region: RuvA_N; pfam01330 1034836007234 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1034836007235 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1034836007236 BofC C-terminal domain; Region: BofC_C; pfam08955 1034836007237 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1034836007238 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836007239 Quinolinate synthetase A protein; Region: NadA; cl00420 1034836007240 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1034836007241 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1034836007242 dimerization interface [polypeptide binding]; other site 1034836007243 active site 1034836007244 L-aspartate oxidase; Provisional; Region: PRK08071 1034836007245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007246 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1034836007247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836007248 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1034836007249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836007250 catalytic residue [active] 1034836007251 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1034836007252 Helix-turn-helix domains; Region: HTH; cl00088 1034836007253 3H domain; Region: 3H; pfam02829 1034836007254 prephenate dehydratase; Provisional; Region: PRK11898 1034836007255 Prephenate dehydratase; Region: PDT; pfam00800 1034836007256 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1034836007257 putative L-Phe binding site [chemical binding]; other site 1034836007258 hypothetical protein; Provisional; Region: PRK04435 1034836007259 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1034836007260 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1034836007261 GTP1/OBG; Region: GTP1_OBG; pfam01018 1034836007262 Obg GTPase; Region: Obg; cd01898 1034836007263 G1 box; other site 1034836007264 GTP/Mg2+ binding site [chemical binding]; other site 1034836007265 Switch I region; other site 1034836007266 G2 box; other site 1034836007267 G3 box; other site 1034836007268 Switch II region; other site 1034836007269 G4 box; other site 1034836007270 G5 box; other site 1034836007271 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1034836007272 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1034836007273 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1034836007274 Protein of unknown function (DUF464); Region: DUF464; cl01080 1034836007275 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1034836007276 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1034836007277 active site 1034836007278 putative substrate binding region [chemical binding]; other site 1034836007279 Peptidase family M23; Region: Peptidase_M23; pfam01551 1034836007280 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1034836007281 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1034836007282 Switch I; other site 1034836007283 Switch II; other site 1034836007284 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1034836007285 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1034836007286 rod shape-determining protein MreD; Region: MreD; cl01087 1034836007287 rod shape-determining protein MreC; Region: mreC; TIGR00219 1034836007288 rod shape-determining protein MreC; Region: MreC; pfam04085 1034836007289 rod shape-determining protein MreB; Provisional; Region: PRK13927 1034836007290 Cell division protein FtsA; Region: FtsA; cl11496 1034836007291 hypothetical protein; Reviewed; Region: PRK00024 1034836007292 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1034836007293 MPN+ (JAMM) motif; other site 1034836007294 Zinc-binding site [ion binding]; other site 1034836007295 Maf-like protein; Region: Maf; pfam02545 1034836007296 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1034836007297 active site 1034836007298 dimer interface [polypeptide binding]; other site 1034836007299 Sporulation related domain; Region: SPOR; cl10051 1034836007300 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1034836007301 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1034836007302 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1034836007303 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1034836007304 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836007305 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034836007306 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1034836007307 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1034836007308 active site 1034836007309 HIGH motif; other site 1034836007310 nucleotide binding site [chemical binding]; other site 1034836007311 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034836007312 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1034836007313 active site 1034836007314 KMSKS motif; other site 1034836007315 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1034836007316 tRNA binding surface [nucleotide binding]; other site 1034836007317 anticodon binding site; other site 1034836007318 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1034836007319 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836007320 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1034836007321 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1034836007322 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1034836007323 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836007324 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1034836007325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836007326 inhibitor-cofactor binding pocket; inhibition site 1034836007327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836007328 catalytic residue [active] 1034836007329 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1034836007330 dimer interface [polypeptide binding]; other site 1034836007331 active site 1034836007332 Schiff base residues; other site 1034836007333 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1034836007334 active site 1034836007335 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 1034836007336 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1034836007337 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1034836007338 domain interfaces; other site 1034836007339 active site 1034836007340 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1034836007341 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1034836007342 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1034836007343 tRNA; other site 1034836007344 putative tRNA binding site [nucleotide binding]; other site 1034836007345 putative NADP binding site [chemical binding]; other site 1034836007346 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1034836007347 Predicted GTPase [General function prediction only]; Region: COG0218 1034836007348 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1034836007349 G1 box; other site 1034836007350 GTP/Mg2+ binding site [chemical binding]; other site 1034836007351 Switch I region; other site 1034836007352 G2 box; other site 1034836007353 G3 box; other site 1034836007354 Switch II region; other site 1034836007355 G4 box; other site 1034836007356 G5 box; other site 1034836007357 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1034836007358 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1034836007359 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1034836007360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007361 Walker A motif; other site 1034836007362 ATP binding site [chemical binding]; other site 1034836007363 Walker B motif; other site 1034836007364 arginine finger; other site 1034836007365 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1034836007366 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1034836007367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007368 Walker A motif; other site 1034836007369 ATP binding site [chemical binding]; other site 1034836007370 Walker B motif; other site 1034836007371 arginine finger; other site 1034836007372 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1034836007373 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1034836007374 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1034836007375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007376 Walker A motif; other site 1034836007377 ATP binding site [chemical binding]; other site 1034836007378 Walker B motif; other site 1034836007379 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1034836007380 trigger factor; Provisional; Region: tig; PRK01490 1034836007381 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1034836007382 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1034836007383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836007384 binding surface 1034836007385 TPR motif; other site 1034836007386 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1034836007387 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1034836007388 substrate binding site [chemical binding]; other site 1034836007389 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1034836007390 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1034836007391 substrate binding site [chemical binding]; other site 1034836007392 ligand binding site [chemical binding]; other site 1034836007393 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1034836007394 tartrate dehydrogenase; Provisional; Region: PRK08194 1034836007395 2-isopropylmalate synthase; Validated; Region: PRK00915 1034836007396 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1034836007397 active site 1034836007398 catalytic residues [active] 1034836007399 metal binding site [ion binding]; metal-binding site 1034836007400 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1034836007401 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1034836007402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007403 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1034836007404 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1034836007405 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1034836007406 putative valine binding site [chemical binding]; other site 1034836007407 dimer interface [polypeptide binding]; other site 1034836007408 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1034836007409 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1034836007410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1034836007411 PYR/PP interface [polypeptide binding]; other site 1034836007412 dimer interface [polypeptide binding]; other site 1034836007413 TPP binding site [chemical binding]; other site 1034836007414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1034836007415 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1034836007416 TPP-binding site [chemical binding]; other site 1034836007417 dimer interface [polypeptide binding]; other site 1034836007418 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1034836007419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034836007420 active site 1034836007421 metal binding site [ion binding]; metal-binding site 1034836007422 homotetramer interface [polypeptide binding]; other site 1034836007423 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1034836007424 active site 1034836007425 dimerization interface [polypeptide binding]; other site 1034836007426 ribonuclease PH; Reviewed; Region: rph; PRK00173 1034836007427 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1034836007428 hexamer interface [polypeptide binding]; other site 1034836007429 active site 1034836007430 Sporulation and spore germination; Region: Germane; cl11253 1034836007431 Spore germination protein [General function prediction only]; Region: COG5401 1034836007432 Sporulation and spore germination; Region: Germane; cl11253 1034836007433 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1034836007434 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836007435 Helix-turn-helix domains; Region: HTH; cl00088 1034836007436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836007437 DNA binding residues [nucleotide binding] 1034836007438 dimerization interface [polypeptide binding]; other site 1034836007439 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1034836007440 active site 1034836007441 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1034836007442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1034836007443 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1034836007444 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1034836007445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007446 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1034836007447 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1034836007448 putative Iron-sulfur protein interface [polypeptide binding]; other site 1034836007449 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1034836007450 proximal heme binding site [chemical binding]; other site 1034836007451 distal heme binding site [chemical binding]; other site 1034836007452 putative dimer interface [polypeptide binding]; other site 1034836007453 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1034836007454 aspartate kinase; Reviewed; Region: PRK06635 1034836007455 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1034836007456 putative nucleotide binding site [chemical binding]; other site 1034836007457 putative catalytic residues [active] 1034836007458 putative Mg ion binding site [ion binding]; other site 1034836007459 putative aspartate binding site [chemical binding]; other site 1034836007460 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1034836007461 putative allosteric regulatory site; other site 1034836007462 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1034836007463 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1034836007464 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1034836007465 GIY-YIG motif/motif A; other site 1034836007466 active site 1034836007467 catalytic site [active] 1034836007468 putative DNA binding site [nucleotide binding]; other site 1034836007469 metal binding site [ion binding]; metal-binding site 1034836007470 UvrB/uvrC motif; Region: UVR; pfam02151 1034836007471 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1034836007472 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034836007473 catalytic residues [active] 1034836007474 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1034836007475 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1034836007476 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1034836007477 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1034836007478 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1034836007479 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1034836007480 Ligand binding site [chemical binding]; other site 1034836007481 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1034836007482 enoyl-CoA hydratase; Provisional; Region: PRK07658 1034836007483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836007484 substrate binding site [chemical binding]; other site 1034836007485 oxyanion hole (OAH) forming residues; other site 1034836007486 trimer interface [polypeptide binding]; other site 1034836007487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836007488 Helix-turn-helix domains; Region: HTH; cl00088 1034836007489 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1034836007490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1034836007491 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836007492 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836007493 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1034836007494 Predicted membrane protein [Function unknown]; Region: COG3766 1034836007495 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1034836007496 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1034836007497 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1034836007498 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 1034836007499 Walker A/P-loop; other site 1034836007500 ATP binding site [chemical binding]; other site 1034836007501 Q-loop/lid; other site 1034836007502 ABC transporter signature motif; other site 1034836007503 Walker B; other site 1034836007504 D-loop; other site 1034836007505 H-loop/switch region; other site 1034836007506 Smr domain; Region: Smr; cl02619 1034836007507 hypothetical protein; Provisional; Region: PRK08609 1034836007508 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1034836007509 active site 1034836007510 primer binding site [nucleotide binding]; other site 1034836007511 NTP binding site [chemical binding]; other site 1034836007512 metal binding triad [ion binding]; metal-binding site 1034836007513 Colicin V production protein; Region: Colicin_V; cl00567 1034836007514 Cell division protein ZapA; Region: ZapA; cl01146 1034836007515 ribonuclease HIII; Provisional; Region: PRK00996 1034836007516 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1034836007517 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1034836007518 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034836007519 active site 1034836007520 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1034836007521 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1034836007522 putative tRNA-binding site [nucleotide binding]; other site 1034836007523 B3/4 domain; Region: B3_4; cl11458 1034836007524 tRNA synthetase B5 domain; Region: B5; cl08394 1034836007525 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1034836007526 dimer interface [polypeptide binding]; other site 1034836007527 motif 1; other site 1034836007528 motif 3; other site 1034836007529 motif 2; other site 1034836007530 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1034836007531 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1034836007532 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1034836007533 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1034836007534 dimer interface [polypeptide binding]; other site 1034836007535 motif 1; other site 1034836007536 active site 1034836007537 motif 2; other site 1034836007538 motif 3; other site 1034836007539 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1034836007540 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1034836007541 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1034836007542 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1034836007543 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1034836007544 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1034836007545 Helix-turn-helix domains; Region: HTH; cl00088 1034836007546 FAD binding domain; Region: FAD_binding_4; pfam01565 1034836007547 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1034836007548 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1034836007549 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1034836007550 Cysteine-rich domain; Region: CCG; pfam02754 1034836007551 Cysteine-rich domain; Region: CCG; pfam02754 1034836007552 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1034836007553 Carbon starvation protein CstA; Region: CstA; pfam02554 1034836007554 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1034836007555 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1034836007556 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1034836007557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007558 dimer interface [polypeptide binding]; other site 1034836007559 conserved gate region; other site 1034836007560 putative PBP binding loops; other site 1034836007561 ABC-ATPase subunit interface; other site 1034836007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007563 dimer interface [polypeptide binding]; other site 1034836007564 conserved gate region; other site 1034836007565 putative PBP binding loops; other site 1034836007566 ABC-ATPase subunit interface; other site 1034836007567 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1034836007568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836007569 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1034836007570 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1034836007571 active site 1034836007572 metal binding site [ion binding]; metal-binding site 1034836007573 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1034836007574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836007575 active site 1034836007576 motif I; other site 1034836007577 motif II; other site 1034836007578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836007579 motif II; other site 1034836007580 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1034836007581 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1034836007582 intersubunit interface [polypeptide binding]; other site 1034836007583 active site 1034836007584 Zn2+ binding site [ion binding]; other site 1034836007585 ribulokinase; Provisional; Region: PRK04123 1034836007586 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1034836007587 putative N- and C-terminal domain interface [polypeptide binding]; other site 1034836007588 putative active site [active] 1034836007589 putative MgATP binding site [chemical binding]; other site 1034836007590 catalytic site [active] 1034836007591 metal binding site [ion binding]; metal-binding site 1034836007592 carbohydrate binding site [chemical binding]; other site 1034836007593 homodimer interface [polypeptide binding]; other site 1034836007594 L-arabinose isomerase; Provisional; Region: PRK02929 1034836007595 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1034836007596 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1034836007597 trimer interface [polypeptide binding]; other site 1034836007598 putative substrate binding site [chemical binding]; other site 1034836007599 putative metal binding site [ion binding]; other site 1034836007600 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1034836007601 substrate binding site [chemical binding]; other site 1034836007602 active site 1034836007603 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1034836007604 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1034836007605 oligomer interface [polypeptide binding]; other site 1034836007606 active site 1034836007607 metal binding site [ion binding]; metal-binding site 1034836007608 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1034836007609 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1034836007610 23S rRNA binding site [nucleotide binding]; other site 1034836007611 L21 binding site [polypeptide binding]; other site 1034836007612 L13 binding site [polypeptide binding]; other site 1034836007613 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1034836007614 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1034836007615 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1034836007616 LrgB-like family; Region: LrgB; cl00596 1034836007617 LrgA family; Region: LrgA; cl00608 1034836007618 two-component response regulator; Provisional; Region: PRK14084 1034836007619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836007620 active site 1034836007621 phosphorylation site [posttranslational modification] 1034836007622 intermolecular recognition site; other site 1034836007623 dimerization interface [polypeptide binding]; other site 1034836007624 LytTr DNA-binding domain; Region: LytTR; cl04498 1034836007625 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1034836007626 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836007627 GAF domain; Region: GAF; cl15785 1034836007628 Histidine kinase; Region: His_kinase; pfam06580 1034836007629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836007630 ATP binding site [chemical binding]; other site 1034836007631 Mg2+ binding site [ion binding]; other site 1034836007632 G-X-G motif; other site 1034836007633 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1034836007634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836007635 motif II; other site 1034836007636 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1034836007637 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1034836007638 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1034836007639 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1034836007640 active site 1034836007641 dimer interface [polypeptide binding]; other site 1034836007642 motif 1; other site 1034836007643 motif 2; other site 1034836007644 motif 3; other site 1034836007645 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1034836007646 anticodon binding site; other site 1034836007647 YtxC-like family; Region: YtxC; cl08500 1034836007648 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1034836007649 primosomal protein DnaI; Reviewed; Region: PRK08939 1034836007650 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1034836007651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836007652 Walker A motif; other site 1034836007653 ATP binding site [chemical binding]; other site 1034836007654 Walker B motif; other site 1034836007655 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1034836007656 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1034836007657 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1034836007658 ATP cone domain; Region: ATP-cone; pfam03477 1034836007659 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1034836007660 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1034836007661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007662 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1034836007663 Helix-turn-helix domains; Region: HTH; cl00088 1034836007664 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836007665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836007666 putative substrate translocation pore; other site 1034836007667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836007668 active site 1034836007669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034836007670 catalytic tetrad [active] 1034836007671 dephospho-CoA kinase; Region: TIGR00152 1034836007672 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1034836007673 CoA-binding site [chemical binding]; other site 1034836007674 ATP-binding [chemical binding]; other site 1034836007675 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1034836007676 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1034836007677 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1034836007678 DNA binding site [nucleotide binding] 1034836007679 catalytic residue [active] 1034836007680 H2TH interface [polypeptide binding]; other site 1034836007681 putative catalytic residues [active] 1034836007682 turnover-facilitating residue; other site 1034836007683 intercalation triad [nucleotide binding]; other site 1034836007684 8OG recognition residue [nucleotide binding]; other site 1034836007685 putative reading head residues; other site 1034836007686 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1034836007687 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1034836007688 DNA polymerase I; Provisional; Region: PRK05755 1034836007689 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1034836007690 active site 1034836007691 metal binding site 1 [ion binding]; metal-binding site 1034836007692 putative 5' ssDNA interaction site; other site 1034836007693 metal binding site 3; metal-binding site 1034836007694 metal binding site 2 [ion binding]; metal-binding site 1034836007695 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1034836007696 putative DNA binding site [nucleotide binding]; other site 1034836007697 putative metal binding site [ion binding]; other site 1034836007698 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1034836007699 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1034836007700 active site 1034836007701 DNA binding site [nucleotide binding] 1034836007702 catalytic site [active] 1034836007703 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1034836007704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836007705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836007706 dimer interface [polypeptide binding]; other site 1034836007707 phosphorylation site [posttranslational modification] 1034836007708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836007709 ATP binding site [chemical binding]; other site 1034836007710 Mg2+ binding site [ion binding]; other site 1034836007711 G-X-G motif; other site 1034836007712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836007713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836007714 active site 1034836007715 phosphorylation site [posttranslational modification] 1034836007716 intermolecular recognition site; other site 1034836007717 dimerization interface [polypeptide binding]; other site 1034836007718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836007719 DNA binding site [nucleotide binding] 1034836007720 malate dehydrogenase; Reviewed; Region: PRK06223 1034836007721 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1034836007722 NAD(P) binding site [chemical binding]; other site 1034836007723 dimer interface [polypeptide binding]; other site 1034836007724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836007725 substrate binding site [chemical binding]; other site 1034836007726 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1034836007727 isocitrate dehydrogenase; Validated; Region: PRK07362 1034836007728 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1034836007729 dimer interface [polypeptide binding]; other site 1034836007730 Citrate synthase; Region: Citrate_synt; pfam00285 1034836007731 active site 1034836007732 citrylCoA binding site [chemical binding]; other site 1034836007733 oxalacetate/citrate binding site [chemical binding]; other site 1034836007734 coenzyme A binding site [chemical binding]; other site 1034836007735 catalytic triad [active] 1034836007736 Protein of unknown function (DUF441); Region: DUF441; cl01041 1034836007737 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836007738 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034836007739 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1034836007740 pyruvate kinase; Provisional; Region: PRK06354 1034836007741 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1034836007742 domain interfaces; other site 1034836007743 active site 1034836007744 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1034836007745 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1034836007746 active site 1034836007747 ADP/pyrophosphate binding site [chemical binding]; other site 1034836007748 dimerization interface [polypeptide binding]; other site 1034836007749 allosteric effector site; other site 1034836007750 fructose-1,6-bisphosphate binding site; other site 1034836007751 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836007752 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1034836007753 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1034836007754 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1034836007755 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1034836007756 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1034836007757 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1034836007758 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1034836007759 putative NAD(P) binding site [chemical binding]; other site 1034836007760 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1034836007761 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1034836007762 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1034836007763 generic binding surface I; other site 1034836007764 generic binding surface II; other site 1034836007765 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1034836007766 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1034836007767 DHH family; Region: DHH; pfam01368 1034836007768 DHHA1 domain; Region: DHHA1; pfam02272 1034836007769 YtpI-like protein; Region: YtpI; pfam14007 1034836007770 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1034836007771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836007772 DNA-binding site [nucleotide binding]; DNA binding site 1034836007773 DRTGG domain; Region: DRTGG; cl12147 1034836007774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1034836007775 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1034836007776 active site 2 [active] 1034836007777 active site 1 [active] 1034836007778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836007779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1034836007780 classical (c) SDRs; Region: SDR_c; cd05233 1034836007781 NAD(P) binding site [chemical binding]; other site 1034836007782 active site 1034836007783 argininosuccinate lyase; Provisional; Region: PRK00855 1034836007784 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1034836007785 active sites [active] 1034836007786 tetramer interface [polypeptide binding]; other site 1034836007787 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1034836007788 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1034836007789 ANP binding site [chemical binding]; other site 1034836007790 Substrate Binding Site II [chemical binding]; other site 1034836007791 Substrate Binding Site I [chemical binding]; other site 1034836007792 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1034836007793 MPT binding site; other site 1034836007794 trimer interface [polypeptide binding]; other site 1034836007795 acetate kinase; Region: ackA; TIGR00016 1034836007796 Acetokinase family; Region: Acetate_kinase; cl01029 1034836007797 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1034836007798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836007799 S-adenosylmethionine binding site [chemical binding]; other site 1034836007800 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1034836007801 dimer interface [polypeptide binding]; other site 1034836007802 catalytic triad [active] 1034836007803 peroxidatic and resolving cysteines [active] 1034836007804 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1034836007805 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1034836007806 RDD family; Region: RDD; cl00746 1034836007807 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1034836007808 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1034836007809 tandem repeat interface [polypeptide binding]; other site 1034836007810 oligomer interface [polypeptide binding]; other site 1034836007811 active site residues [active] 1034836007812 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1034836007813 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1034836007814 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1034836007815 active site 1034836007816 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1034836007817 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836007818 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836007819 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1034836007820 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1034836007821 THUMP domain; Region: THUMP; cl12076 1034836007822 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1034836007823 Ligand Binding Site [chemical binding]; other site 1034836007824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836007825 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1034836007826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836007827 catalytic residue [active] 1034836007828 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1034836007829 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1034836007830 TMPIT-like protein; Region: TMPIT; pfam07851 1034836007831 histidinol-phosphatase; Reviewed; Region: PRK08123 1034836007832 PHP-associated; Region: PHP_C; pfam13263 1034836007833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836007834 Helix-turn-helix domains; Region: HTH; cl00088 1034836007835 GAF domain; Region: GAF; cl15785 1034836007836 GAF domain; Region: GAF_2; pfam13185 1034836007837 GAF domain; Region: GAF; cl15785 1034836007838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1034836007839 metal binding site [ion binding]; metal-binding site 1034836007840 active site 1034836007841 I-site; other site 1034836007842 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1034836007843 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1034836007844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836007845 RNA binding surface [nucleotide binding]; other site 1034836007846 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1034836007847 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1034836007848 heme-binding site [chemical binding]; other site 1034836007849 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1034836007850 FAD binding pocket [chemical binding]; other site 1034836007851 FAD binding motif [chemical binding]; other site 1034836007852 phosphate binding motif [ion binding]; other site 1034836007853 beta-alpha-beta structure motif; other site 1034836007854 NAD binding pocket [chemical binding]; other site 1034836007855 Heme binding pocket [chemical binding]; other site 1034836007856 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1034836007857 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1034836007858 active site 1034836007859 catalytic triad [active] 1034836007860 oxyanion hole [active] 1034836007861 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034836007862 Cation efflux family; Region: Cation_efflux; cl00316 1034836007863 Predicted transcriptional regulators [Transcription]; Region: COG1378 1034836007864 Helix-turn-helix domains; Region: HTH; cl00088 1034836007865 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1034836007866 C-terminal domain interface [polypeptide binding]; other site 1034836007867 sugar binding site [chemical binding]; other site 1034836007868 AzlC protein; Region: AzlC; cl00570 1034836007869 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1034836007870 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1034836007871 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1034836007872 active site 1034836007873 HIGH motif; other site 1034836007874 dimer interface [polypeptide binding]; other site 1034836007875 KMSKS motif; other site 1034836007876 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836007877 RNA binding surface [nucleotide binding]; other site 1034836007878 acetyl-CoA synthetase; Provisional; Region: PRK04319 1034836007879 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1034836007880 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836007881 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836007882 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836007883 FOG: CBS domain [General function prediction only]; Region: COG0517 1034836007884 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1034836007885 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1034836007886 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1034836007887 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1034836007888 flagellar motor protein MotS; Reviewed; Region: PRK06925 1034836007889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1034836007890 ligand binding site [chemical binding]; other site 1034836007891 flagellar motor protein MotP; Reviewed; Region: PRK06926 1034836007892 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1034836007893 catabolite control protein A; Region: ccpA; TIGR01481 1034836007894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836007895 DNA binding site [nucleotide binding] 1034836007896 domain linker motif; other site 1034836007897 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1034836007898 dimerization interface [polypeptide binding]; other site 1034836007899 effector binding site; other site 1034836007900 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1034836007901 Chorismate mutase type II; Region: CM_2; cl00693 1034836007902 NeuB family; Region: NeuB; cl00496 1034836007903 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1034836007904 YtxH-like protein; Region: YtxH; cl02079 1034836007905 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1034836007906 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1034836007907 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034836007908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836007909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034836007910 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1034836007911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836007912 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1034836007913 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1034836007914 putative tRNA-binding site [nucleotide binding]; other site 1034836007915 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1034836007916 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034836007917 catalytic residues [active] 1034836007918 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 1034836007919 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1034836007920 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1034836007921 oligomer interface [polypeptide binding]; other site 1034836007922 active site 1034836007923 metal binding site [ion binding]; metal-binding site 1034836007924 Predicted small secreted protein [Function unknown]; Region: COG5584 1034836007925 malate dehydrogenase; Provisional; Region: PRK13529 1034836007926 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1034836007927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1034836007928 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1034836007929 NAD(P) binding site [chemical binding]; other site 1034836007930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836007931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836007932 S-adenosylmethionine binding site [chemical binding]; other site 1034836007933 YtzH-like protein; Region: YtzH; pfam14165 1034836007934 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1034836007935 active site 1034836007936 substrate binding site [chemical binding]; other site 1034836007937 ATP binding site [chemical binding]; other site 1034836007938 Phosphotransferase enzyme family; Region: APH; pfam01636 1034836007939 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1034836007940 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1034836007941 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1034836007942 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1034836007943 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1034836007944 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1034836007945 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1034836007946 dimer interface [polypeptide binding]; other site 1034836007947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836007948 catalytic residue [active] 1034836007949 dipeptidase PepV; Reviewed; Region: PRK07318 1034836007950 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1034836007951 active site 1034836007952 metal binding site [ion binding]; metal-binding site 1034836007953 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1034836007954 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1034836007955 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034836007956 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1034836007957 Walker A/P-loop; other site 1034836007958 ATP binding site [chemical binding]; other site 1034836007959 Q-loop/lid; other site 1034836007960 ABC transporter signature motif; other site 1034836007961 Walker B; other site 1034836007962 D-loop; other site 1034836007963 H-loop/switch region; other site 1034836007964 Helix-turn-helix domains; Region: HTH; cl00088 1034836007965 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1034836007966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034836007967 RNA binding surface [nucleotide binding]; other site 1034836007968 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1034836007969 active site 1034836007970 uracil binding [chemical binding]; other site 1034836007971 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1034836007972 MatE; Region: MatE; cl10513 1034836007973 MatE; Region: MatE; cl10513 1034836007974 HI0933-like protein; Region: HI0933_like; pfam03486 1034836007975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836007977 BCCT family transporter; Region: BCCT; cl00569 1034836007978 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1034836007979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836007980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836007981 DNA binding site [nucleotide binding] 1034836007982 domain linker motif; other site 1034836007983 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1034836007984 putative ligand binding site [chemical binding]; other site 1034836007985 putative dimerization interface [polypeptide binding]; other site 1034836007986 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1034836007987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836007988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836007989 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1034836007990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007991 dimer interface [polypeptide binding]; other site 1034836007992 conserved gate region; other site 1034836007993 putative PBP binding loops; other site 1034836007994 ABC-ATPase subunit interface; other site 1034836007995 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1034836007996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836007997 dimer interface [polypeptide binding]; other site 1034836007998 conserved gate region; other site 1034836007999 putative PBP binding loops; other site 1034836008000 ABC-ATPase subunit interface; other site 1034836008001 alpha-galactosidase; Provisional; Region: PRK15076 1034836008002 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1034836008003 NAD binding site [chemical binding]; other site 1034836008004 sugar binding site [chemical binding]; other site 1034836008005 divalent metal binding site [ion binding]; other site 1034836008006 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836008007 dimer interface [polypeptide binding]; other site 1034836008008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1034836008009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836008010 Coenzyme A binding pocket [chemical binding]; other site 1034836008011 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1034836008012 active site residue [active] 1034836008013 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1034836008014 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1034836008015 HIGH motif; other site 1034836008016 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034836008017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1034836008018 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1034836008019 active site 1034836008020 KMSKS motif; other site 1034836008021 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1034836008022 tRNA binding surface [nucleotide binding]; other site 1034836008023 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1034836008024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034836008025 PAS domain; Region: PAS_9; pfam13426 1034836008026 putative active site [active] 1034836008027 heme pocket [chemical binding]; other site 1034836008028 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1034836008029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836008030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836008031 putative substrate translocation pore; other site 1034836008032 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1034836008033 FtsX-like permease family; Region: FtsX; cl15850 1034836008034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034836008035 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1034836008036 Walker A/P-loop; other site 1034836008037 ATP binding site [chemical binding]; other site 1034836008038 Q-loop/lid; other site 1034836008039 ABC transporter signature motif; other site 1034836008040 Walker B; other site 1034836008041 D-loop; other site 1034836008042 H-loop/switch region; other site 1034836008043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1034836008044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008045 ATP binding site [chemical binding]; other site 1034836008046 Mg2+ binding site [ion binding]; other site 1034836008047 G-X-G motif; other site 1034836008048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836008049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008050 active site 1034836008051 phosphorylation site [posttranslational modification] 1034836008052 intermolecular recognition site; other site 1034836008053 dimerization interface [polypeptide binding]; other site 1034836008054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836008055 DNA binding site [nucleotide binding] 1034836008056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1034836008057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1034836008058 FtsX-like permease family; Region: FtsX; cl15850 1034836008059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034836008060 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1034836008061 Walker A/P-loop; other site 1034836008062 ATP binding site [chemical binding]; other site 1034836008063 Q-loop/lid; other site 1034836008064 ABC transporter signature motif; other site 1034836008065 Walker B; other site 1034836008066 D-loop; other site 1034836008067 H-loop/switch region; other site 1034836008068 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836008069 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836008070 potential frameshift: common BLAST hit: gi|154687224|ref|YP_001422385.1| hypothetical protein RBAM_028220 1034836008071 Predicted transcriptional regulators [Transcription]; Region: COG1725 1034836008072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836008073 DNA-binding site [nucleotide binding]; DNA binding site 1034836008074 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1034836008075 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1034836008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836008077 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1034836008078 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1034836008079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008080 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008081 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1034836008082 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1034836008083 trimer interface [polypeptide binding]; other site 1034836008084 putative metal binding site [ion binding]; other site 1034836008085 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034836008086 Spore germination protein; Region: Spore_permease; cl15802 1034836008087 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1034836008088 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1034836008089 active site 1034836008090 dimer interface [polypeptide binding]; other site 1034836008091 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1034836008092 Ligand Binding Site [chemical binding]; other site 1034836008093 Molecular Tunnel; other site 1034836008094 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1034836008095 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1034836008096 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1034836008097 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1034836008098 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1034836008099 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1034836008100 active site 1034836008101 substrate-binding site [chemical binding]; other site 1034836008102 metal-binding site [ion binding] 1034836008103 ATP binding site [chemical binding]; other site 1034836008104 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1034836008105 Dienelactone hydrolase family; Region: DLH; pfam01738 1034836008106 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008107 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1034836008108 NMT1-like family; Region: NMT1_2; cl15260 1034836008109 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1034836008110 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1034836008111 Walker A/P-loop; other site 1034836008112 ATP binding site [chemical binding]; other site 1034836008113 Q-loop/lid; other site 1034836008114 ABC transporter signature motif; other site 1034836008115 Walker B; other site 1034836008116 D-loop; other site 1034836008117 H-loop/switch region; other site 1034836008118 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1034836008119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836008120 dimer interface [polypeptide binding]; other site 1034836008121 conserved gate region; other site 1034836008122 putative PBP binding loops; other site 1034836008123 ABC-ATPase subunit interface; other site 1034836008124 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1034836008125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1034836008126 nudix motif; other site 1034836008127 Holin family; Region: Phage_holin_4; cl01989 1034836008128 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1034836008129 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1034836008130 dimerization interface [polypeptide binding]; other site 1034836008131 DPS ferroxidase diiron center [ion binding]; other site 1034836008132 ion pore; other site 1034836008133 FixH; Region: FixH; cl01254 1034836008134 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1034836008135 Haemolytic domain; Region: Haemolytic; cl00506 1034836008136 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1034836008137 active site clefts [active] 1034836008138 zinc binding site [ion binding]; other site 1034836008139 dimer interface [polypeptide binding]; other site 1034836008140 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1034836008141 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1034836008142 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1034836008143 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1034836008144 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1034836008145 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1034836008146 active site 1034836008147 octamer interface [polypeptide binding]; other site 1034836008148 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1034836008149 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836008151 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1034836008152 substrate binding site [chemical binding]; other site 1034836008153 oxyanion hole (OAH) forming residues; other site 1034836008154 trimer interface [polypeptide binding]; other site 1034836008155 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008156 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1034836008157 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1034836008158 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1034836008159 dimer interface [polypeptide binding]; other site 1034836008160 tetramer interface [polypeptide binding]; other site 1034836008161 PYR/PP interface [polypeptide binding]; other site 1034836008162 TPP binding site [chemical binding]; other site 1034836008163 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1034836008164 TPP-binding site; other site 1034836008165 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1034836008166 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1034836008167 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1034836008168 TspO/MBR family; Region: TspO_MBR; cl01379 1034836008169 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836008170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1034836008171 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1034836008172 DinB superfamily; Region: DinB_2; pfam12867 1034836008173 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836008174 MOSC domain; Region: MOSC; pfam03473 1034836008175 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1034836008176 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1034836008177 active site 1034836008178 NAD binding site [chemical binding]; other site 1034836008179 metal binding site [ion binding]; metal-binding site 1034836008180 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1034836008181 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836008182 tetramerization interface [polypeptide binding]; other site 1034836008183 NAD(P) binding site [chemical binding]; other site 1034836008184 catalytic residues [active] 1034836008185 Predicted transcriptional regulators [Transcription]; Region: COG1510 1034836008186 Helix-turn-helix domains; Region: HTH; cl00088 1034836008187 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1034836008188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008189 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836008190 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1034836008191 SH3-like domain; Region: SH3_8; pfam13457 1034836008192 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1034836008193 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1034836008194 heme-binding site [chemical binding]; other site 1034836008195 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1034836008196 FAD binding pocket [chemical binding]; other site 1034836008197 FAD binding motif [chemical binding]; other site 1034836008198 phosphate binding motif [ion binding]; other site 1034836008199 beta-alpha-beta structure motif; other site 1034836008200 NAD binding pocket [chemical binding]; other site 1034836008201 Heme binding pocket [chemical binding]; other site 1034836008202 Cupin domain; Region: Cupin_2; cl09118 1034836008203 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836008204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836008205 binding surface 1034836008206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836008207 TPR motif; other site 1034836008208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836008209 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034836008210 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1034836008211 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1034836008212 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1034836008213 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1034836008214 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836008215 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1034836008216 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1034836008217 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1034836008218 Phage tail protein; Region: Sipho_tail; pfam05709 1034836008219 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 1034836008220 Phage-related minor tail protein [Function unknown]; Region: COG5280 1034836008221 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1034836008222 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034836008223 catalytic residue [active] 1034836008224 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1034836008225 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1034836008226 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1034836008227 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1034836008228 Phage capsid family; Region: Phage_capsid; pfam05065 1034836008229 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1034836008230 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1034836008231 Phage portal protein; Region: Phage_portal; pfam04860 1034836008232 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1034836008233 Phage Terminase; Region: Terminase_1; pfam03354 1034836008234 Phage terminase, small subunit; Region: Terminase_4; cl01525 1034836008235 BRO family, N-terminal domain; Region: Bro-N; cl10591 1034836008236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836008237 non-specific DNA binding site [nucleotide binding]; other site 1034836008238 salt bridge; other site 1034836008239 sequence-specific DNA binding site [nucleotide binding]; other site 1034836008240 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1034836008241 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1034836008242 Int/Topo IB signature motif; other site 1034836008243 Bacitracin resistance protein BacA; Region: BacA; cl00858 1034836008244 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034836008245 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836008246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1034836008247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008248 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1034836008249 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1034836008250 proposed catalytic triad [active] 1034836008251 conserved cys residue [active] 1034836008252 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1034836008253 Cache domain; Region: Cache_1; pfam02743 1034836008254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008255 dimerization interface [polypeptide binding]; other site 1034836008256 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1034836008257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836008258 dimer interface [polypeptide binding]; other site 1034836008259 putative CheW interface [polypeptide binding]; other site 1034836008260 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1034836008261 Cache domain; Region: Cache_1; pfam02743 1034836008262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008263 dimerization interface [polypeptide binding]; other site 1034836008264 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1034836008265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836008266 dimer interface [polypeptide binding]; other site 1034836008267 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1034836008268 putative CheW interface [polypeptide binding]; other site 1034836008269 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1034836008270 Cache domain; Region: Cache_1; pfam02743 1034836008271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008272 dimerization interface [polypeptide binding]; other site 1034836008273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1034836008274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836008275 dimer interface [polypeptide binding]; other site 1034836008276 putative CheW interface [polypeptide binding]; other site 1034836008277 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1034836008278 Cache domain; Region: Cache_1; pfam02743 1034836008279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008280 dimerization interface [polypeptide binding]; other site 1034836008281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1034836008282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1034836008283 dimer interface [polypeptide binding]; other site 1034836008284 putative CheW interface [polypeptide binding]; other site 1034836008285 transglutaminase; Provisional; Region: tgl; PRK03187 1034836008286 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1034836008287 Nitronate monooxygenase; Region: NMO; pfam03060 1034836008288 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1034836008289 FMN binding site [chemical binding]; other site 1034836008290 substrate binding site [chemical binding]; other site 1034836008291 putative catalytic residue [active] 1034836008292 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1034836008293 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1034836008294 Ca binding site [ion binding]; other site 1034836008295 active site 1034836008296 catalytic site [active] 1034836008297 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1034836008298 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034836008299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034836008300 Transporter associated domain; Region: CorC_HlyC; cl08393 1034836008301 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1034836008302 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1034836008303 Ion channel; Region: Ion_trans_2; cl11596 1034836008304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008305 YugN-like family; Region: YugN; pfam08868 1034836008306 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1034836008307 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1034836008308 active site 1034836008309 dimer interface [polypeptide binding]; other site 1034836008310 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1034836008311 dimer interface [polypeptide binding]; other site 1034836008312 active site 1034836008313 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1034836008314 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1034836008315 dimer interface [polypeptide binding]; other site 1034836008316 active site 1034836008317 metal binding site [ion binding]; metal-binding site 1034836008318 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1034836008319 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1034836008320 dimer interface [polypeptide binding]; other site 1034836008321 active site 1034836008322 metal binding site [ion binding]; metal-binding site 1034836008323 Domain of unknown function (DUF378); Region: DUF378; cl00943 1034836008324 general stress protein 13; Validated; Region: PRK08059 1034836008325 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1034836008326 RNA binding site [nucleotide binding]; other site 1034836008327 hypothetical protein; Validated; Region: PRK07682 1034836008328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836008329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836008330 homodimer interface [polypeptide binding]; other site 1034836008331 catalytic residue [active] 1034836008332 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1034836008333 AsnC family; Region: AsnC_trans_reg; pfam01037 1034836008334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1034836008335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008336 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1034836008337 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1034836008338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836008339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836008340 homodimer interface [polypeptide binding]; other site 1034836008341 catalytic residue [active] 1034836008342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836008343 dimer interface [polypeptide binding]; other site 1034836008344 phosphorylation site [posttranslational modification] 1034836008345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008346 ATP binding site [chemical binding]; other site 1034836008347 Mg2+ binding site [ion binding]; other site 1034836008348 G-X-G motif; other site 1034836008349 Kinase associated protein B; Region: KapB; pfam08810 1034836008350 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1034836008351 active site 1034836008352 catalytic site [active] 1034836008353 substrate binding site [chemical binding]; other site 1034836008354 sugar efflux transporter; Region: 2A0120; TIGR00899 1034836008355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836008356 putative substrate translocation pore; other site 1034836008357 Transglycosylase; Region: Transgly; cl07896 1034836008358 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1034836008359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836008360 Protein of unknown function, DUF393; Region: DUF393; cl01136 1034836008361 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1034836008362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836008363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008364 ATP binding site [chemical binding]; other site 1034836008365 Mg2+ binding site [ion binding]; other site 1034836008366 G-X-G motif; other site 1034836008367 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1034836008368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008369 active site 1034836008370 phosphorylation site [posttranslational modification] 1034836008371 intermolecular recognition site; other site 1034836008372 dimerization interface [polypeptide binding]; other site 1034836008373 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1034836008374 ligand binding site [chemical binding]; other site 1034836008375 potential frameshift: common BLAST hit: gi|154687266|ref|YP_001422427.1| YufO 1034836008376 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1034836008377 TM-ABC transporter signature motif; other site 1034836008378 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1034836008379 TM-ABC transporter signature motif; other site 1034836008380 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1034836008381 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1034836008382 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1034836008383 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1034836008384 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1034836008385 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1034836008386 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1034836008387 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1034836008388 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1034836008389 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1034836008390 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1034836008391 CoenzymeA binding site [chemical binding]; other site 1034836008392 subunit interaction site [polypeptide binding]; other site 1034836008393 PHB binding site; other site 1034836008394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008396 active site 1034836008397 phosphorylation site [posttranslational modification] 1034836008398 intermolecular recognition site; other site 1034836008399 dimerization interface [polypeptide binding]; other site 1034836008400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836008401 DNA binding residues [nucleotide binding] 1034836008402 dimerization interface [polypeptide binding]; other site 1034836008403 potential frameshift: common BLAST hit: gi|154687278|ref|YP_001422439.1| ComP 1034836008404 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1034836008405 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1034836008406 aspartate-rich region 2; other site 1034836008407 DegQ (SacQ) family; Region: DegQ; pfam08181 1034836008408 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1034836008409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1034836008410 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1034836008411 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1034836008412 active site 1034836008413 Isochorismatase family; Region: Isochorismatase; pfam00857 1034836008414 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1034836008415 catalytic triad [active] 1034836008416 conserved cis-peptide bond; other site 1034836008417 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1034836008418 YueH-like protein; Region: YueH; pfam14166 1034836008419 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1034836008420 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034836008421 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1034836008422 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1034836008423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1034836008424 short chain dehydrogenase; Provisional; Region: PRK06924 1034836008425 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1034836008426 NADP binding site [chemical binding]; other site 1034836008427 homodimer interface [polypeptide binding]; other site 1034836008428 active site 1034836008429 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1034836008430 Predicted membrane protein [Function unknown]; Region: COG1511 1034836008431 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1034836008432 Predicted membrane protein [Function unknown]; Region: COG1511 1034836008433 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 1034836008434 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1034836008435 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1034836008436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836008437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836008438 Domain of unknown function DUF87; Region: DUF87; pfam01935 1034836008439 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1034836008440 Ubiquitin-like proteins; Region: UBQ; cl00155 1034836008441 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1034836008442 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1034836008443 CodY GAF-like domain; Region: CodY; pfam06018 1034836008444 Helix-turn-helix domains; Region: HTH; cl00088 1034836008445 alanine dehydrogenase; Region: alaDH; TIGR00518 1034836008446 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1034836008447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008448 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1034836008449 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1034836008450 MbtH-like protein; Region: MbtH; cl01279 1034836008451 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1034836008452 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008453 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836008454 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1034836008455 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034836008456 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008457 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008458 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836008459 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1034836008460 hydrophobic substrate binding pocket; other site 1034836008461 Isochorismatase family; Region: Isochorismatase; pfam00857 1034836008462 active site 1034836008463 conserved cis-peptide bond; other site 1034836008464 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836008465 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1034836008466 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008467 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836008468 isochorismate synthase DhbC; Validated; Region: PRK06923 1034836008469 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1034836008470 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1034836008471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008472 NAD(P) binding site [chemical binding]; other site 1034836008473 active site 1034836008474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008475 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1034836008476 Moco binding site; other site 1034836008477 metal coordination site [ion binding]; other site 1034836008478 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1034836008479 Predicted permease [General function prediction only]; Region: COG2056 1034836008480 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1034836008481 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1034836008482 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1034836008483 interface (dimer of trimers) [polypeptide binding]; other site 1034836008484 Substrate-binding/catalytic site; other site 1034836008485 Zn-binding sites [ion binding]; other site 1034836008486 Divergent PAP2 family; Region: DUF212; cl00855 1034836008487 3D domain; Region: 3D; cl01439 1034836008488 Putative membrane protein; Region: YuiB; pfam14068 1034836008489 chaperone protein DnaJ; Provisional; Region: PRK14290 1034836008490 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1034836008491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836008492 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1034836008493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836008494 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1034836008495 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1034836008496 active site 1034836008497 Integral membrane protein DUF95; Region: DUF95; cl00572 1034836008498 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034836008499 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1034836008500 Walker A/P-loop; other site 1034836008501 ATP binding site [chemical binding]; other site 1034836008502 Q-loop/lid; other site 1034836008503 ABC transporter signature motif; other site 1034836008504 Walker B; other site 1034836008505 D-loop; other site 1034836008506 H-loop/switch region; other site 1034836008507 potential frameshift: common BLAST hit: gi|154687326|ref|YP_001422487.1| YjcK 1034836008508 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1034836008509 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1034836008510 putative NAD(P) binding site [chemical binding]; other site 1034836008511 active site 1034836008512 Phage holin; Region: Phage_holin_5; pfam06946 1034836008513 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034836008514 amidase catalytic site [active] 1034836008515 Zn binding residues [ion binding]; other site 1034836008516 substrate binding site [chemical binding]; other site 1034836008517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034836008518 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1034836008519 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1034836008520 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034836008521 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1034836008522 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1034836008523 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1034836008524 Phage tail protein; Region: Sipho_tail; pfam05709 1034836008525 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1034836008526 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1034836008527 Phosphoinositide-specific phospholipase C, efhand-like; Region: efhand_like; pfam09279 1034836008528 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1034836008529 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 1034836008530 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1034836008531 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 1034836008532 Helix-turn-helix domains; Region: HTH; cl00088 1034836008533 DNA-binding interface [nucleotide binding]; DNA binding site 1034836008534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1034836008535 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1034836008536 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1034836008537 Int/Topo IB signature motif; other site 1034836008538 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1034836008539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836008540 Helix-turn-helix domains; Region: HTH; cl00088 1034836008541 Predicted transcriptional regulator [Transcription]; Region: COG3355 1034836008542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034836008543 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1034836008544 active site 1034836008545 DNA binding site [nucleotide binding] 1034836008546 Int/Topo IB signature motif; other site 1034836008547 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1034836008548 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1034836008549 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1034836008550 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1034836008551 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1034836008552 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034836008553 Nucleoside recognition; Region: Gate; cl00486 1034836008554 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034836008555 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1034836008556 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1034836008557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836008558 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 1034836008559 NifU-like domain; Region: NifU; cl00484 1034836008560 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1034836008561 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1034836008562 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1034836008563 structural tetrad; other site 1034836008564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836008565 homoserine kinase; Provisional; Region: PRK01212 1034836008566 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034836008567 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034836008568 threonine synthase; Reviewed; Region: PRK06721 1034836008569 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1034836008570 homodimer interface [polypeptide binding]; other site 1034836008571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836008572 catalytic residue [active] 1034836008573 homoserine dehydrogenase; Provisional; Region: PRK06349 1034836008574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008575 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1034836008576 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1034836008577 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836008578 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1034836008579 tetramer interfaces [polypeptide binding]; other site 1034836008580 binuclear metal-binding site [ion binding]; other site 1034836008581 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1034836008582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836008583 active site 1034836008584 motif I; other site 1034836008585 motif II; other site 1034836008586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836008587 Protein of unknown function DUF86; Region: DUF86; cl01031 1034836008588 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1034836008589 lipoyl synthase; Provisional; Region: PRK05481 1034836008590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836008591 FeS/SAM binding site; other site 1034836008592 Peptidase family M23; Region: Peptidase_M23; pfam01551 1034836008593 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1034836008594 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1034836008595 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1034836008596 active site 1034836008597 metal binding site [ion binding]; metal-binding site 1034836008598 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034836008599 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1034836008600 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1034836008601 Protein of unknown function DUF72; Region: DUF72; cl00777 1034836008602 allantoinase; Provisional; Region: PRK06189 1034836008603 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1034836008604 active site 1034836008605 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1034836008606 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1034836008607 Helix-turn-helix domains; Region: HTH; cl00088 1034836008608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836008609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836008610 putative substrate translocation pore; other site 1034836008611 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1034836008612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836008613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836008614 catalytic residue [active] 1034836008615 allantoate amidohydrolase; Reviewed; Region: PRK09290 1034836008616 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1034836008617 active site 1034836008618 metal binding site [ion binding]; metal-binding site 1034836008619 dimer interface [polypeptide binding]; other site 1034836008620 Endonuclease I; Region: Endonuclease_1; cl01003 1034836008621 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1034836008622 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1034836008623 Walker A/P-loop; other site 1034836008624 ATP binding site [chemical binding]; other site 1034836008625 Q-loop/lid; other site 1034836008626 ABC transporter signature motif; other site 1034836008627 Walker B; other site 1034836008628 D-loop; other site 1034836008629 H-loop/switch region; other site 1034836008630 TOBE domain; Region: TOBE_2; cl01440 1034836008631 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1034836008632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836008633 DNA-binding site [nucleotide binding]; DNA binding site 1034836008634 UTRA domain; Region: UTRA; cl01230 1034836008635 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1034836008636 substrate binding site [chemical binding]; other site 1034836008637 ATP binding site [chemical binding]; other site 1034836008638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1034836008639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836008640 dimer interface [polypeptide binding]; other site 1034836008641 conserved gate region; other site 1034836008642 putative PBP binding loops; other site 1034836008643 ABC-ATPase subunit interface; other site 1034836008644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836008645 dimer interface [polypeptide binding]; other site 1034836008646 conserved gate region; other site 1034836008647 putative PBP binding loops; other site 1034836008648 ABC-ATPase subunit interface; other site 1034836008649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1034836008650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836008651 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1034836008652 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1034836008653 putative active site [active] 1034836008654 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1034836008655 dimer interface [polypeptide binding]; other site 1034836008656 active site 1034836008657 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1034836008658 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1034836008659 DNA binding residues [nucleotide binding] 1034836008660 dimer interface [polypeptide binding]; other site 1034836008661 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1034836008662 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1034836008663 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1034836008664 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1034836008665 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1034836008666 GIY-YIG motif/motif A; other site 1034836008667 active site 1034836008668 catalytic site [active] 1034836008669 putative DNA binding site [nucleotide binding]; other site 1034836008670 metal binding site [ion binding]; metal-binding site 1034836008671 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1034836008672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836008674 S-adenosylmethionine binding site [chemical binding]; other site 1034836008675 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1034836008676 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1034836008677 chitosan binding site [chemical binding]; other site 1034836008678 catalytic residues [active] 1034836008679 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1034836008680 FeS assembly protein SufB; Region: sufB; TIGR01980 1034836008681 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1034836008682 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1034836008683 trimerization site [polypeptide binding]; other site 1034836008684 active site 1034836008685 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1034836008686 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1034836008687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836008688 catalytic residue [active] 1034836008689 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1034836008690 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1034836008691 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1034836008692 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1034836008693 Walker A/P-loop; other site 1034836008694 ATP binding site [chemical binding]; other site 1034836008695 Q-loop/lid; other site 1034836008696 ABC transporter signature motif; other site 1034836008697 Walker B; other site 1034836008698 D-loop; other site 1034836008699 H-loop/switch region; other site 1034836008700 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1034836008701 NMT1-like family; Region: NMT1_2; cl15260 1034836008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836008703 dimer interface [polypeptide binding]; other site 1034836008704 conserved gate region; other site 1034836008705 ABC-ATPase subunit interface; other site 1034836008706 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1034836008707 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1034836008708 Walker A/P-loop; other site 1034836008709 ATP binding site [chemical binding]; other site 1034836008710 Q-loop/lid; other site 1034836008711 ABC transporter signature motif; other site 1034836008712 Walker B; other site 1034836008713 D-loop; other site 1034836008714 H-loop/switch region; other site 1034836008715 NIL domain; Region: NIL; cl09633 1034836008716 SCP-2 sterol transfer family; Region: SCP2; cl01225 1034836008717 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034836008718 catalytic residues [active] 1034836008719 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1034836008720 putative active site [active] 1034836008721 putative metal binding site [ion binding]; other site 1034836008722 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1034836008723 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1034836008724 lipoyl attachment site [posttranslational modification]; other site 1034836008725 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1034836008726 ArsC family; Region: ArsC; pfam03960 1034836008727 putative ArsC-like catalytic residues; other site 1034836008728 putative TRX-like catalytic residues [active] 1034836008729 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1034836008730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1034836008731 active site 1034836008732 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1034836008733 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1034836008734 dimer interface [polypeptide binding]; other site 1034836008735 active site 1034836008736 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1034836008737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008738 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1034836008739 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1034836008740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034836008741 substrate binding site [chemical binding]; other site 1034836008742 oxyanion hole (OAH) forming residues; other site 1034836008743 trimer interface [polypeptide binding]; other site 1034836008744 YuzL-like protein; Region: YuzL; pfam14115 1034836008745 Proline dehydrogenase; Region: Pro_dh; cl03282 1034836008746 Pyruvate formate lyase; Region: PFL; pfam02901 1034836008747 Coat F domain; Region: Coat_F; cl15836 1034836008748 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836008749 Helix-turn-helix domains; Region: HTH; cl00088 1034836008750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836008751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836008752 putative substrate translocation pore; other site 1034836008753 Restriction endonuclease BamHI; Region: BamHI; pfam02923 1034836008754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836008755 non-specific DNA binding site [nucleotide binding]; other site 1034836008756 salt bridge; other site 1034836008757 sequence-specific DNA binding site [nucleotide binding]; other site 1034836008758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836008759 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1034836008760 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034836008761 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034836008762 Walker A/P-loop; other site 1034836008763 ATP binding site [chemical binding]; other site 1034836008764 Q-loop/lid; other site 1034836008765 ABC transporter signature motif; other site 1034836008766 Walker B; other site 1034836008767 D-loop; other site 1034836008768 H-loop/switch region; other site 1034836008769 YusW-like protein; Region: YusW; pfam14039 1034836008770 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1034836008771 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1034836008772 active site 1034836008773 Zn binding site [ion binding]; other site 1034836008774 short chain dehydrogenase; Provisional; Region: PRK06914 1034836008775 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1034836008776 NADP binding site [chemical binding]; other site 1034836008777 active site 1034836008778 steroid binding site; other site 1034836008779 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1034836008780 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1034836008781 dimerization interface [polypeptide binding]; other site 1034836008782 DPS ferroxidase diiron center [ion binding]; other site 1034836008783 ion pore; other site 1034836008784 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1034836008785 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034836008786 protein binding site [polypeptide binding]; other site 1034836008787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836008788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008789 active site 1034836008790 phosphorylation site [posttranslational modification] 1034836008791 intermolecular recognition site; other site 1034836008792 dimerization interface [polypeptide binding]; other site 1034836008793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836008794 DNA binding site [nucleotide binding] 1034836008795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034836008796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008797 dimerization interface [polypeptide binding]; other site 1034836008798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836008799 dimer interface [polypeptide binding]; other site 1034836008800 phosphorylation site [posttranslational modification] 1034836008801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008802 ATP binding site [chemical binding]; other site 1034836008803 Mg2+ binding site [ion binding]; other site 1034836008804 G-X-G motif; other site 1034836008805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836008806 Helix-turn-helix domains; Region: HTH; cl00088 1034836008807 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1034836008808 Class II fumarases; Region: Fumarase_classII; cd01362 1034836008809 active site 1034836008810 tetramer interface [polypeptide binding]; other site 1034836008811 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1034836008812 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1034836008813 Spore germination protein; Region: Spore_permease; cl15802 1034836008814 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1034836008815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836008816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008817 active site 1034836008818 phosphorylation site [posttranslational modification] 1034836008819 intermolecular recognition site; other site 1034836008820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836008821 DNA binding residues [nucleotide binding] 1034836008822 dimerization interface [polypeptide binding]; other site 1034836008823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034836008824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836008825 dimerization interface [polypeptide binding]; other site 1034836008826 Histidine kinase; Region: HisKA_3; pfam07730 1034836008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008828 ATP binding site [chemical binding]; other site 1034836008829 Mg2+ binding site [ion binding]; other site 1034836008830 G-X-G motif; other site 1034836008831 Predicted membrane protein [Function unknown]; Region: COG4758 1034836008832 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1034836008833 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1034836008834 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1034836008835 PspA/IM30 family; Region: PspA_IM30; pfam04012 1034836008836 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1034836008837 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1034836008838 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1034836008839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836008840 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034836008841 putative substrate translocation pore; other site 1034836008842 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1034836008843 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034836008844 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034836008845 Walker A/P-loop; other site 1034836008846 ATP binding site [chemical binding]; other site 1034836008847 Q-loop/lid; other site 1034836008848 ABC transporter signature motif; other site 1034836008849 Walker B; other site 1034836008850 D-loop; other site 1034836008851 H-loop/switch region; other site 1034836008852 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1034836008853 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034836008854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836008855 ABC-ATPase subunit interface; other site 1034836008856 dimer interface [polypeptide binding]; other site 1034836008857 putative PBP binding regions; other site 1034836008858 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034836008859 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1034836008860 putative binding site residues; other site 1034836008861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1034836008862 classical (c) SDRs; Region: SDR_c; cd05233 1034836008863 NAD(P) binding site [chemical binding]; other site 1034836008864 active site 1034836008865 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1034836008866 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1034836008867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836008868 dimer interface [polypeptide binding]; other site 1034836008869 phosphorylation site [posttranslational modification] 1034836008870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836008871 ATP binding site [chemical binding]; other site 1034836008872 Mg2+ binding site [ion binding]; other site 1034836008873 G-X-G motif; other site 1034836008874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836008875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008876 active site 1034836008877 phosphorylation site [posttranslational modification] 1034836008878 intermolecular recognition site; other site 1034836008879 dimerization interface [polypeptide binding]; other site 1034836008880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836008881 DNA binding site [nucleotide binding] 1034836008882 hypothetical protein; Provisional; Region: PRK14082 1034836008883 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1034836008884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034836008885 DNA binding residues [nucleotide binding] 1034836008886 YvrJ protein family; Region: YvrJ; pfam12841 1034836008887 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1034836008888 Cupin domain; Region: Cupin_2; cl09118 1034836008889 Cupin domain; Region: Cupin_2; cl09118 1034836008890 Regulatory protein YrvL; Region: YrvL; pfam14184 1034836008891 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034836008892 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034836008893 Walker A/P-loop; other site 1034836008894 ATP binding site [chemical binding]; other site 1034836008895 Q-loop/lid; other site 1034836008896 ABC transporter signature motif; other site 1034836008897 Walker B; other site 1034836008898 D-loop; other site 1034836008899 H-loop/switch region; other site 1034836008900 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034836008901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836008902 ABC-ATPase subunit interface; other site 1034836008903 dimer interface [polypeptide binding]; other site 1034836008904 putative PBP binding regions; other site 1034836008905 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034836008906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836008907 ABC-ATPase subunit interface; other site 1034836008908 dimer interface [polypeptide binding]; other site 1034836008909 putative PBP binding regions; other site 1034836008910 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034836008911 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1034836008912 putative ligand binding residues [chemical binding]; other site 1034836008913 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1034836008914 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1034836008915 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1034836008916 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1034836008917 Sulfatase; Region: Sulfatase; cl10460 1034836008918 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034836008919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836008920 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1034836008921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034836008922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836008923 dimer interface [polypeptide binding]; other site 1034836008924 conserved gate region; other site 1034836008925 putative PBP binding loops; other site 1034836008926 ABC-ATPase subunit interface; other site 1034836008927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836008928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836008929 active site 1034836008930 phosphorylation site [posttranslational modification] 1034836008931 intermolecular recognition site; other site 1034836008932 dimerization interface [polypeptide binding]; other site 1034836008933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836008934 DNA binding residues [nucleotide binding] 1034836008935 dimerization interface [polypeptide binding]; other site 1034836008936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034836008937 Histidine kinase; Region: HisKA_3; pfam07730 1034836008938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1034836008939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034836008940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836008941 Walker A/P-loop; other site 1034836008942 ATP binding site [chemical binding]; other site 1034836008943 Q-loop/lid; other site 1034836008944 ABC transporter signature motif; other site 1034836008945 Walker B; other site 1034836008946 D-loop; other site 1034836008947 H-loop/switch region; other site 1034836008948 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1034836008949 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836008950 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1034836008951 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836008952 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836008953 active site 1034836008954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034836008955 catalytic tetrad [active] 1034836008956 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1034836008957 sulfite reductase subunit beta; Provisional; Region: PRK13504 1034836008958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034836008959 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034836008960 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1034836008961 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836008962 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1034836008963 FAD binding pocket [chemical binding]; other site 1034836008964 FAD binding motif [chemical binding]; other site 1034836008965 catalytic residues [active] 1034836008966 NAD binding pocket [chemical binding]; other site 1034836008967 phosphate binding motif [ion binding]; other site 1034836008968 beta-alpha-beta structure motif; other site 1034836008969 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1034836008970 Family description; Region: UvrD_C_2; cl15862 1034836008971 Predicted membrane protein [Function unknown]; Region: COG2860 1034836008972 UPF0126 domain; Region: UPF0126; pfam03458 1034836008973 UPF0126 domain; Region: UPF0126; pfam03458 1034836008974 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1034836008975 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1034836008976 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1034836008977 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1034836008978 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034836008979 metal-binding site [ion binding] 1034836008980 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034836008981 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836008982 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034836008983 metal-binding site [ion binding] 1034836008984 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1034836008985 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034836008986 metal-binding site [ion binding] 1034836008987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034836008988 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836008989 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034836008990 metal-binding site [ion binding] 1034836008991 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1034836008992 putative homodimer interface [polypeptide binding]; other site 1034836008993 putative homotetramer interface [polypeptide binding]; other site 1034836008994 putative allosteric switch controlling residues; other site 1034836008995 putative metal binding site [ion binding]; other site 1034836008996 putative homodimer-homodimer interface [polypeptide binding]; other site 1034836008997 putative oxidoreductase; Provisional; Region: PRK11579 1034836008998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836008999 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1034836009000 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836009001 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1034836009002 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1034836009003 active site 1034836009004 non-prolyl cis peptide bond; other site 1034836009005 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1034836009006 catalytic residues [active] 1034836009007 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1034836009008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034836009009 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034836009010 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1034836009011 Walker A/P-loop; other site 1034836009012 ATP binding site [chemical binding]; other site 1034836009013 Q-loop/lid; other site 1034836009014 ABC transporter signature motif; other site 1034836009015 Walker B; other site 1034836009016 D-loop; other site 1034836009017 H-loop/switch region; other site 1034836009018 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034836009019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009020 dimer interface [polypeptide binding]; other site 1034836009021 conserved gate region; other site 1034836009022 putative PBP binding loops; other site 1034836009023 ABC-ATPase subunit interface; other site 1034836009024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1034836009025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009026 dimer interface [polypeptide binding]; other site 1034836009027 conserved gate region; other site 1034836009028 putative PBP binding loops; other site 1034836009029 ABC-ATPase subunit interface; other site 1034836009030 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034836009031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836009032 substrate binding pocket [chemical binding]; other site 1034836009033 membrane-bound complex binding site; other site 1034836009034 hinge residues; other site 1034836009035 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1034836009036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034836009037 substrate binding pocket [chemical binding]; other site 1034836009038 membrane-bound complex binding site; other site 1034836009039 hinge residues; other site 1034836009040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836009041 Coenzyme A binding pocket [chemical binding]; other site 1034836009042 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836009043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836009044 Helix-turn-helix domains; Region: HTH; cl00088 1034836009045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836009046 dimerization interface [polypeptide binding]; other site 1034836009047 potential frameshift: common BLAST hit: gi|375363802|ref|YP_005131841.1| 3-oxoacyl-ACP reductase 1034836009048 short chain dehydrogenase; Provisional; Region: PRK06523 1034836009049 classical (c) SDRs; Region: SDR_c; cd05233 1034836009050 NAD(P) binding site [chemical binding]; other site 1034836009051 active site 1034836009052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009053 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1034836009054 RNAase interaction site [polypeptide binding]; other site 1034836009055 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1034836009056 SmpB-tmRNA interface; other site 1034836009057 ribonuclease R; Region: RNase_R; TIGR02063 1034836009058 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1034836009059 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1034836009060 RNB domain; Region: RNB; pfam00773 1034836009061 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1034836009062 RNA binding site [nucleotide binding]; other site 1034836009063 Esterase/lipase [General function prediction only]; Region: COG1647 1034836009064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836009065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1034836009066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836009067 salt bridge; other site 1034836009068 non-specific DNA binding site [nucleotide binding]; other site 1034836009069 sequence-specific DNA binding site [nucleotide binding]; other site 1034836009070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034836009071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836009072 non-specific DNA binding site [nucleotide binding]; other site 1034836009073 salt bridge; other site 1034836009074 sequence-specific DNA binding site [nucleotide binding]; other site 1034836009075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836009076 non-specific DNA binding site [nucleotide binding]; other site 1034836009077 salt bridge; other site 1034836009078 sequence-specific DNA binding site [nucleotide binding]; other site 1034836009079 Helix-turn-helix domains; Region: HTH; cl00088 1034836009080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836009081 dimer interface [polypeptide binding]; other site 1034836009082 phosphorylation site [posttranslational modification] 1034836009083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836009084 ATP binding site [chemical binding]; other site 1034836009085 Mg2+ binding site [ion binding]; other site 1034836009086 G-X-G motif; other site 1034836009087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836009088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836009089 active site 1034836009090 phosphorylation site [posttranslational modification] 1034836009091 intermolecular recognition site; other site 1034836009092 dimerization interface [polypeptide binding]; other site 1034836009093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836009094 DNA binding site [nucleotide binding] 1034836009095 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836009096 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836009097 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1034836009098 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1034836009099 Walker A/P-loop; other site 1034836009100 ATP binding site [chemical binding]; other site 1034836009101 Q-loop/lid; other site 1034836009102 ABC transporter signature motif; other site 1034836009103 Walker B; other site 1034836009104 D-loop; other site 1034836009105 H-loop/switch region; other site 1034836009106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009107 dimer interface [polypeptide binding]; other site 1034836009108 conserved gate region; other site 1034836009109 putative PBP binding loops; other site 1034836009110 ABC-ATPase subunit interface; other site 1034836009111 NMT1-like family; Region: NMT1_2; cl15260 1034836009112 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1034836009113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009114 dimer interface [polypeptide binding]; other site 1034836009115 conserved gate region; other site 1034836009116 putative PBP binding loops; other site 1034836009117 ABC-ATPase subunit interface; other site 1034836009118 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1034836009119 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1034836009120 Walker A/P-loop; other site 1034836009121 ATP binding site [chemical binding]; other site 1034836009122 Q-loop/lid; other site 1034836009123 ABC transporter signature motif; other site 1034836009124 Walker B; other site 1034836009125 D-loop; other site 1034836009126 H-loop/switch region; other site 1034836009127 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1034836009128 Predicted transcriptional regulators [Transcription]; Region: COG1510 1034836009129 Helix-turn-helix domains; Region: HTH; cl00088 1034836009130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009131 dimer interface [polypeptide binding]; other site 1034836009132 conserved gate region; other site 1034836009133 putative PBP binding loops; other site 1034836009134 ABC-ATPase subunit interface; other site 1034836009135 NMT1-like family; Region: NMT1_2; cl15260 1034836009136 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1034836009137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034836009138 dimer interface [polypeptide binding]; other site 1034836009139 conserved gate region; other site 1034836009140 putative PBP binding loops; other site 1034836009141 ABC-ATPase subunit interface; other site 1034836009142 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1034836009143 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1034836009144 Walker A/P-loop; other site 1034836009145 ATP binding site [chemical binding]; other site 1034836009146 Q-loop/lid; other site 1034836009147 ABC transporter signature motif; other site 1034836009148 Walker B; other site 1034836009149 D-loop; other site 1034836009150 H-loop/switch region; other site 1034836009151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1034836009152 Predicted transcriptional regulators [Transcription]; Region: COG1510 1034836009153 Helix-turn-helix domains; Region: HTH; cl00088 1034836009154 MarC family integral membrane protein; Region: MarC; cl00919 1034836009155 potential frameshift: common BLAST hit: gi|154687515|ref|YP_001422676.1| YvbJ 1034836009156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836009157 Coenzyme A binding pocket [chemical binding]; other site 1034836009158 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034836009159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009160 putative substrate translocation pore; other site 1034836009161 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1034836009162 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1034836009163 WbqC-like protein family; Region: WbqC; pfam08889 1034836009164 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836009165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034836009166 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1034836009167 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034836009168 catalytic residue [active] 1034836009169 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1034836009170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009171 NAD(P) binding site [chemical binding]; other site 1034836009172 active site 1034836009173 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1034836009174 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1034836009175 inhibitor-cofactor binding pocket; inhibition site 1034836009176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836009177 catalytic residue [active] 1034836009178 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1034836009179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009180 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1034836009181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009182 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1034836009183 PA/protease domain interface [polypeptide binding]; other site 1034836009184 putative integrin binding motif; other site 1034836009185 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1034836009186 metal binding site [ion binding]; metal-binding site 1034836009187 enolase; Provisional; Region: eno; PRK00077 1034836009188 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1034836009189 dimer interface [polypeptide binding]; other site 1034836009190 metal binding site [ion binding]; metal-binding site 1034836009191 substrate binding pocket [chemical binding]; other site 1034836009192 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1034836009193 Sulfatase; Region: Sulfatase; cl10460 1034836009194 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1034836009195 substrate binding site [chemical binding]; other site 1034836009196 dimer interface [polypeptide binding]; other site 1034836009197 catalytic triad [active] 1034836009198 Phosphoglycerate kinase; Region: PGK; pfam00162 1034836009199 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1034836009200 substrate binding site [chemical binding]; other site 1034836009201 hinge regions; other site 1034836009202 ADP binding site [chemical binding]; other site 1034836009203 catalytic site [active] 1034836009204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009205 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1034836009206 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1034836009207 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1034836009208 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1034836009209 cation transport protein; Region: 2A0119; TIGR00898 1034836009210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836009212 DNA-binding site [nucleotide binding]; DNA binding site 1034836009213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836009214 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1034836009215 putative dimerization interface [polypeptide binding]; other site 1034836009216 putative ligand binding site [chemical binding]; other site 1034836009217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034836009218 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1034836009219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836009220 Helix-turn-helix domains; Region: HTH; cl00088 1034836009221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836009222 dimerization interface [polypeptide binding]; other site 1034836009223 EamA-like transporter family; Region: EamA; cl01037 1034836009224 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1034836009225 EamA-like transporter family; Region: EamA; cl01037 1034836009226 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034836009227 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034836009228 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034836009229 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034836009230 putative active site [active] 1034836009231 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1034836009232 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1034836009233 N- and C-terminal domain interface [polypeptide binding]; other site 1034836009234 putative active site [active] 1034836009235 catalytic site [active] 1034836009236 metal binding site [ion binding]; metal-binding site 1034836009237 carbohydrate binding site [chemical binding]; other site 1034836009238 ATP binding site [chemical binding]; other site 1034836009239 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1034836009240 GntP family permease; Region: GntP_permease; pfam02447 1034836009241 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1034836009242 iron-sulfur cluster-binding protein; Region: TIGR00273 1034836009243 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1034836009244 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1034836009245 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1034836009246 Cysteine-rich domain; Region: CCG; pfam02754 1034836009247 Cysteine-rich domain; Region: CCG; pfam02754 1034836009248 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1034836009249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836009250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836009251 homodimer interface [polypeptide binding]; other site 1034836009252 catalytic residue [active] 1034836009253 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1034836009254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836009255 DNA-binding site [nucleotide binding]; DNA binding site 1034836009256 FCD domain; Region: FCD; cl11656 1034836009257 glycolate transporter; Provisional; Region: PRK09695 1034836009258 L-lactate permease; Region: Lactate_perm; cl00701 1034836009259 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1034836009260 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1034836009261 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1034836009262 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1034836009263 YvfG protein; Region: YvfG; pfam09628 1034836009264 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1034836009265 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1034836009266 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1034836009267 inhibitor-cofactor binding pocket; inhibition site 1034836009268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836009269 catalytic residue [active] 1034836009270 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1034836009271 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1034836009272 putative trimer interface [polypeptide binding]; other site 1034836009273 putative CoA binding site [chemical binding]; other site 1034836009274 Bacterial sugar transferase; Region: Bac_transf; cl00939 1034836009275 MatE; Region: MatE; cl10513 1034836009276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836009277 active site 1034836009278 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1034836009279 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034836009280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836009281 active site 1034836009282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034836009283 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1034836009284 putative ADP-binding pocket [chemical binding]; other site 1034836009285 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034836009286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1034836009287 active site 1034836009288 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1034836009289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034836009290 putative ADP-binding pocket [chemical binding]; other site 1034836009291 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1034836009292 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1034836009293 NAD(P) binding site [chemical binding]; other site 1034836009294 homodimer interface [polypeptide binding]; other site 1034836009295 substrate binding site [chemical binding]; other site 1034836009296 active site 1034836009297 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1034836009298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009299 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1034836009300 Chain length determinant protein; Region: Wzz; cl15801 1034836009301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034836009302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034836009303 non-specific DNA binding site [nucleotide binding]; other site 1034836009304 salt bridge; other site 1034836009305 sequence-specific DNA binding site [nucleotide binding]; other site 1034836009306 Anti-repressor SinI; Region: SinI; pfam08671 1034836009307 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1034836009308 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1034836009309 substrate binding pocket [chemical binding]; other site 1034836009310 catalytic triad [active] 1034836009311 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1034836009312 folate binding site [chemical binding]; other site 1034836009313 NADP+ binding site [chemical binding]; other site 1034836009314 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1034836009315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836009318 Predicted membrane protein [Function unknown]; Region: COG2364 1034836009319 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836009320 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836009321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836009322 Coenzyme A binding pocket [chemical binding]; other site 1034836009323 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1034836009324 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1034836009325 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034836009326 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034836009327 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034836009328 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1034836009329 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1034836009330 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1034836009331 substrate binding [chemical binding]; other site 1034836009332 active site 1034836009333 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1034836009334 galactoside permease; Reviewed; Region: lacY; PRK09528 1034836009335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009336 putative substrate translocation pore; other site 1034836009337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836009338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836009339 DNA binding site [nucleotide binding] 1034836009340 domain linker motif; other site 1034836009341 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1034836009342 dimerization interface [polypeptide binding]; other site 1034836009343 ligand binding site [chemical binding]; other site 1034836009344 sodium binding site [ion binding]; other site 1034836009345 Clp protease; Region: CLP_protease; pfam00574 1034836009346 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1034836009347 oligomer interface [polypeptide binding]; other site 1034836009348 active site residues [active] 1034836009349 Helix-turn-helix domains; Region: HTH; cl00088 1034836009350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034836009351 dimerization interface [polypeptide binding]; other site 1034836009352 PrpF protein; Region: PrpF; pfam04303 1034836009353 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1034836009354 benzoate transport; Region: 2A0115; TIGR00895 1034836009355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009356 putative substrate translocation pore; other site 1034836009357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009358 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1034836009359 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1034836009360 metal binding site [ion binding]; metal-binding site 1034836009361 putative transporter; Provisional; Region: PRK11660 1034836009362 Sulfate transporter family; Region: Sulfate_transp; cl15842 1034836009363 Sulfate transporter family; Region: Sulfate_transp; cl15842 1034836009364 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1034836009365 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1034836009366 active site clefts [active] 1034836009367 zinc binding site [ion binding]; other site 1034836009368 dimer interface [polypeptide binding]; other site 1034836009369 glyoxylate reductase; Reviewed; Region: PRK13243 1034836009370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009371 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1034836009372 active site 1034836009373 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1034836009374 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1034836009375 dimerization domain swap beta strand [polypeptide binding]; other site 1034836009376 regulatory protein interface [polypeptide binding]; other site 1034836009377 active site 1034836009378 regulatory phosphorylation site [posttranslational modification]; other site 1034836009379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1034836009380 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1034836009381 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1034836009382 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1034836009383 phosphate binding site [ion binding]; other site 1034836009384 putative substrate binding pocket [chemical binding]; other site 1034836009385 dimer interface [polypeptide binding]; other site 1034836009386 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1034836009387 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1034836009388 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1034836009389 putative active site [active] 1034836009390 nucleotide binding site [chemical binding]; other site 1034836009391 nudix motif; other site 1034836009392 putative metal binding site [ion binding]; other site 1034836009393 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1034836009394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836009396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1034836009397 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 1034836009398 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836009399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836009400 binding surface 1034836009401 TPR motif; other site 1034836009402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836009403 TPR motif; other site 1034836009404 binding surface 1034836009405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836009406 dimer interface [polypeptide binding]; other site 1034836009407 phosphorylation site [posttranslational modification] 1034836009408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836009409 ATP binding site [chemical binding]; other site 1034836009410 Mg2+ binding site [ion binding]; other site 1034836009411 G-X-G motif; other site 1034836009412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836009413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836009414 active site 1034836009415 phosphorylation site [posttranslational modification] 1034836009416 intermolecular recognition site; other site 1034836009417 dimerization interface [polypeptide binding]; other site 1034836009418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836009419 DNA binding site [nucleotide binding] 1034836009420 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836009421 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836009422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009423 Walker A/P-loop; other site 1034836009424 ATP binding site [chemical binding]; other site 1034836009425 Q-loop/lid; other site 1034836009426 ABC transporter signature motif; other site 1034836009427 Walker B; other site 1034836009428 D-loop; other site 1034836009429 H-loop/switch region; other site 1034836009430 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1034836009431 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1034836009432 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1034836009433 metal binding site [ion binding]; metal-binding site 1034836009434 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1034836009435 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1034836009436 substrate binding site [chemical binding]; other site 1034836009437 glutamase interaction surface [polypeptide binding]; other site 1034836009438 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1034836009439 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1034836009440 catalytic residues [active] 1034836009441 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1034836009442 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1034836009443 putative active site [active] 1034836009444 oxyanion strand; other site 1034836009445 catalytic triad [active] 1034836009446 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1034836009447 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1034836009448 putative active site pocket [active] 1034836009449 4-fold oligomerization interface [polypeptide binding]; other site 1034836009450 metal binding residues [ion binding]; metal-binding site 1034836009451 3-fold/trimer interface [polypeptide binding]; other site 1034836009452 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1034836009453 histidinol dehydrogenase; Region: hisD; TIGR00069 1034836009454 NAD binding site [chemical binding]; other site 1034836009455 dimerization interface [polypeptide binding]; other site 1034836009456 product binding site; other site 1034836009457 substrate binding site [chemical binding]; other site 1034836009458 zinc binding site [ion binding]; other site 1034836009459 catalytic residues [active] 1034836009460 ATP phosphoribosyltransferase; Region: HisG; cl15266 1034836009461 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1034836009462 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1034836009463 dimer interface [polypeptide binding]; other site 1034836009464 motif 1; other site 1034836009465 active site 1034836009466 motif 2; other site 1034836009467 motif 3; other site 1034836009468 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1034836009469 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 1034836009470 putative active site [active] 1034836009471 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1034836009472 trimer interface [polypeptide binding]; other site 1034836009473 active site 1034836009474 substrate binding site [chemical binding]; other site 1034836009475 CoA binding site [chemical binding]; other site 1034836009476 pyrophosphatase PpaX; Provisional; Region: PRK13288 1034836009477 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836009478 motif I; other site 1034836009479 active site 1034836009480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836009481 motif II; other site 1034836009482 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1034836009483 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1034836009484 DRTGG domain; Region: DRTGG; cl12147 1034836009485 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1034836009486 Hpr binding site; other site 1034836009487 active site 1034836009488 homohexamer subunit interaction site [polypeptide binding]; other site 1034836009489 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1034836009490 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1034836009491 active site 1034836009492 dimer interface [polypeptide binding]; other site 1034836009493 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1034836009494 active site 1034836009495 trimer interface [polypeptide binding]; other site 1034836009496 allosteric site; other site 1034836009497 active site lid [active] 1034836009498 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1034836009499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034836009500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836009501 DNA-binding site [nucleotide binding]; DNA binding site 1034836009502 UTRA domain; Region: UTRA; cl01230 1034836009503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836009504 Helix-turn-helix domains; Region: HTH; cl00088 1034836009505 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1034836009506 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1034836009507 putative active site [active] 1034836009508 putative metal binding site [ion binding]; other site 1034836009509 Membrane protein of unknown function; Region: DUF360; cl00850 1034836009510 PspC domain; Region: PspC; cl00864 1034836009511 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1034836009512 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1034836009513 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1034836009514 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1034836009515 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1034836009516 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1034836009517 excinuclease ABC subunit B; Provisional; Region: PRK05298 1034836009518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836009519 ATP binding site [chemical binding]; other site 1034836009520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836009521 nucleotide binding region [chemical binding]; other site 1034836009522 ATP-binding site [chemical binding]; other site 1034836009523 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1034836009524 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1034836009525 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1034836009526 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1034836009527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1034836009528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836009529 Helix-turn-helix domains; Region: HTH; cl00088 1034836009530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009531 putative substrate translocation pore; other site 1034836009532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034836009533 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1034836009534 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1034836009535 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1034836009536 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1034836009537 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1034836009538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034836009539 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1034836009540 C-terminal peptidase (prc); Region: prc; TIGR00225 1034836009541 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1034836009542 protein binding site [polypeptide binding]; other site 1034836009543 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1034836009544 Catalytic dyad [active] 1034836009545 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1034836009546 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1034836009547 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1034836009548 FtsX-like permease family; Region: FtsX; cl15850 1034836009549 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1034836009550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009551 Walker A/P-loop; other site 1034836009552 ATP binding site [chemical binding]; other site 1034836009553 Q-loop/lid; other site 1034836009554 ABC transporter signature motif; other site 1034836009555 Walker B; other site 1034836009556 D-loop; other site 1034836009557 H-loop/switch region; other site 1034836009558 Cytochrome c; Region: Cytochrom_C; cl11414 1034836009559 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836009560 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836009561 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836009562 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836009563 peptide chain release factor 2; Provisional; Region: PRK06746 1034836009564 RF-1 domain; Region: RF-1; cl02875 1034836009565 RF-1 domain; Region: RF-1; cl02875 1034836009566 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1034836009567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009568 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1034836009569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009570 SEC-C motif; Region: SEC-C; pfam02810 1034836009571 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1034836009572 30S subunit binding site; other site 1034836009573 Flagellar protein FliT; Region: FliT; cl05125 1034836009574 Flagellar protein FliS; Region: FliS; cl00654 1034836009575 flagellar capping protein; Validated; Region: fliD; PRK07737 1034836009576 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1034836009577 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1034836009578 flagellin; Provisional; Region: PRK12804 1034836009579 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1034836009580 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1034836009581 Global regulator protein family; Region: CsrA; cl00670 1034836009582 FliW protein; Region: FliW; cl00740 1034836009583 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1034836009584 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1034836009585 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1034836009586 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1034836009587 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1034836009588 FlgN protein; Region: FlgN; cl09176 1034836009589 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1034836009590 flagellar operon protein TIGR03826; Region: YvyF 1034836009591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836009592 active site 1034836009593 Late competence development protein ComFB; Region: ComFB; pfam10719 1034836009594 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1034836009595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836009596 ATP binding site [chemical binding]; other site 1034836009597 putative Mg++ binding site [ion binding]; other site 1034836009598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836009599 nucleotide binding region [chemical binding]; other site 1034836009600 ATP-binding site [chemical binding]; other site 1034836009601 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1034836009602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836009603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836009604 active site 1034836009605 phosphorylation site [posttranslational modification] 1034836009606 intermolecular recognition site; other site 1034836009607 dimerization interface [polypeptide binding]; other site 1034836009608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836009609 DNA binding residues [nucleotide binding] 1034836009610 dimerization interface [polypeptide binding]; other site 1034836009611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034836009612 Histidine kinase; Region: HisKA_3; pfam07730 1034836009613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836009614 ATP binding site [chemical binding]; other site 1034836009615 Mg2+ binding site [ion binding]; other site 1034836009616 G-X-G motif; other site 1034836009617 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1034836009618 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1034836009619 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1034836009620 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1034836009621 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1034836009622 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1034836009623 Mg++ binding site [ion binding]; other site 1034836009624 putative catalytic motif [active] 1034836009625 substrate binding site [chemical binding]; other site 1034836009626 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1034836009627 putative homodimer interface [polypeptide binding]; other site 1034836009628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836009629 active site 1034836009630 Chain length determinant protein; Region: Wzz; cl15801 1034836009631 O-Antigen ligase; Region: Wzy_C; cl04850 1034836009632 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1034836009633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009634 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1034836009635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009636 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1034836009637 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 1034836009638 colanic acid exporter; Provisional; Region: PRK10459 1034836009639 MatE; Region: MatE; cl10513 1034836009640 Bacterial sugar transferase; Region: Bac_transf; cl00939 1034836009641 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1034836009642 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009643 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009644 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009645 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034836009646 active site 1034836009647 metal binding site [ion binding]; metal-binding site 1034836009648 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009649 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1034836009650 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009651 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1034836009652 Stage II sporulation protein; Region: SpoIID; pfam08486 1034836009653 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1034836009654 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1034836009655 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1034836009656 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1034836009657 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1034836009658 active site 1034836009659 homodimer interface [polypeptide binding]; other site 1034836009660 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1034836009661 active site 1034836009662 tetramer interface; other site 1034836009663 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1034836009664 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1034836009665 Walker A/P-loop; other site 1034836009666 ATP binding site [chemical binding]; other site 1034836009667 Q-loop/lid; other site 1034836009668 ABC transporter signature motif; other site 1034836009669 Walker B; other site 1034836009670 D-loop; other site 1034836009671 H-loop/switch region; other site 1034836009672 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836009673 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034836009674 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1034836009675 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1034836009676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034836009677 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1034836009678 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1034836009679 active site 1034836009680 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1034836009681 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034836009682 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1034836009683 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836009684 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1034836009685 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1034836009686 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1034836009687 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1034836009688 Spore germination protein; Region: Spore_permease; cl15802 1034836009689 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1034836009690 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1034836009691 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1034836009692 Probable Catalytic site; other site 1034836009693 metal-binding site 1034836009694 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1034836009695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836009696 S-adenosylmethionine binding site [chemical binding]; other site 1034836009697 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1034836009698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009699 putative substrate translocation pore; other site 1034836009700 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1034836009701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836009702 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836009703 active site 1034836009704 motif I; other site 1034836009705 motif II; other site 1034836009706 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1034836009707 Protein of unknown function (DUF904); Region: DUF904; cl11531 1034836009708 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836009709 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836009710 NlpC/P60 family; Region: NLPC_P60; cl11438 1034836009711 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1034836009712 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1034836009713 putative active site [active] 1034836009714 putative metal binding site [ion binding]; other site 1034836009715 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1034836009716 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1034836009717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034836009718 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1034836009719 Spore germination protein; Region: Spore_permease; cl15802 1034836009720 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1034836009721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836009722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836009723 DNA binding site [nucleotide binding] 1034836009724 domain linker motif; other site 1034836009725 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1034836009726 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034836009727 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1034836009728 substrate binding site [chemical binding]; other site 1034836009729 dimer interface [polypeptide binding]; other site 1034836009730 ATP binding site [chemical binding]; other site 1034836009731 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1034836009732 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1034836009733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836009734 Walker A/P-loop; other site 1034836009735 ATP binding site [chemical binding]; other site 1034836009736 Q-loop/lid; other site 1034836009737 ABC transporter signature motif; other site 1034836009738 Walker B; other site 1034836009739 D-loop; other site 1034836009740 H-loop/switch region; other site 1034836009741 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1034836009742 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1034836009743 TM-ABC transporter signature motif; other site 1034836009744 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1034836009745 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1034836009746 ligand binding site [chemical binding]; other site 1034836009747 dimerization interface [polypeptide binding]; other site 1034836009748 Bacterial SH3 domain; Region: SH3_3; cl02551 1034836009749 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1034836009750 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1034836009751 acetolactate synthase; Reviewed; Region: PRK08617 1034836009752 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1034836009753 PYR/PP interface [polypeptide binding]; other site 1034836009754 dimer interface [polypeptide binding]; other site 1034836009755 TPP binding site [chemical binding]; other site 1034836009756 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1034836009757 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1034836009758 TPP-binding site [chemical binding]; other site 1034836009759 dimer interface [polypeptide binding]; other site 1034836009760 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1034836009761 Helix-turn-helix domains; Region: HTH; cl00088 1034836009762 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1034836009763 putative dimerization interface [polypeptide binding]; other site 1034836009764 putative substrate binding pocket [chemical binding]; other site 1034836009765 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1034836009766 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1034836009767 transmembrane helices; other site 1034836009768 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1034836009769 Flavin Reductases; Region: FlaRed; cl00801 1034836009770 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1034836009771 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1034836009772 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1034836009773 Helix-turn-helix domains; Region: HTH; cl00088 1034836009774 AsnC family; Region: AsnC_trans_reg; pfam01037 1034836009775 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1034836009776 Chromate transporter; Region: Chromate_transp; pfam02417 1034836009777 Chromate transporter; Region: Chromate_transp; pfam02417 1034836009778 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1034836009779 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1034836009780 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1034836009781 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1034836009782 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1034836009783 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1034836009784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009785 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1034836009786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836009787 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1034836009788 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1034836009789 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1034836009790 Nucleotide binding site [chemical binding]; other site 1034836009791 Chain length determinant protein; Region: Wzz; cl15801 1034836009792 SWIM zinc finger; Region: SWIM; cl15408 1034836009793 SNF2 Helicase protein; Region: DUF3670; pfam12419 1034836009794 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1034836009795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034836009796 ATP binding site [chemical binding]; other site 1034836009797 putative Mg++ binding site [ion binding]; other site 1034836009798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836009799 nucleotide binding region [chemical binding]; other site 1034836009800 ATP-binding site [chemical binding]; other site 1034836009801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836009802 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034836009803 active site 1034836009804 motif I; other site 1034836009805 motif II; other site 1034836009806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836009807 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034836009808 Helix-turn-helix domains; Region: HTH; cl00088 1034836009809 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836009810 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1034836009811 dimer interface [polypeptide binding]; other site 1034836009812 ssDNA binding site [nucleotide binding]; other site 1034836009813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836009814 YwpF-like protein; Region: YwpF; pfam14183 1034836009815 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1034836009816 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1034836009817 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1034836009818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836009819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836009820 binding surface 1034836009821 TPR motif; other site 1034836009822 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1034836009823 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1034836009824 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1034836009825 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1034836009826 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1034836009827 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1034836009828 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1034836009829 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1034836009830 ATP binding site [chemical binding]; other site 1034836009831 profilin binding site; other site 1034836009832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1034836009833 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836009834 Helix-turn-helix domains; Region: HTH; cl00088 1034836009835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836009836 putative substrate translocation pore; other site 1034836009837 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1034836009838 Na binding site [ion binding]; other site 1034836009839 putative substrate binding site [chemical binding]; other site 1034836009840 potential frameshift: common BLAST hit: gi|154687765|ref|YP_001422926.1| YwoD 1034836009841 Isochorismatase family; Region: Isochorismatase; pfam00857 1034836009842 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1034836009843 catalytic triad [active] 1034836009844 conserved cis-peptide bond; other site 1034836009845 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1034836009846 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1034836009847 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1034836009848 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1034836009849 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1034836009850 active site 1034836009851 VanZ like family; Region: VanZ; cl01971 1034836009852 Peptidase family M23; Region: Peptidase_M23; pfam01551 1034836009853 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1034836009854 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1034836009855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836009856 Coenzyme A binding pocket [chemical binding]; other site 1034836009857 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1034836009858 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1034836009859 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1034836009860 putative active site [active] 1034836009861 catalytic site [active] 1034836009862 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1034836009863 putative active site [active] 1034836009864 catalytic site [active] 1034836009865 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1034836009866 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034836009867 NAD binding site [chemical binding]; other site 1034836009868 substrate binding site [chemical binding]; other site 1034836009869 putative active site [active] 1034836009870 Predicted transcriptional regulator [Transcription]; Region: COG1959 1034836009871 Helix-turn-helix domains; Region: HTH; cl00088 1034836009872 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1034836009873 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1034836009874 subunit interactions [polypeptide binding]; other site 1034836009875 active site 1034836009876 flap region; other site 1034836009877 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1034836009878 gamma-beta subunit interface [polypeptide binding]; other site 1034836009879 alpha-beta subunit interface [polypeptide binding]; other site 1034836009880 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1034836009881 alpha-gamma subunit interface [polypeptide binding]; other site 1034836009882 beta-gamma subunit interface [polypeptide binding]; other site 1034836009883 CsbD-like; Region: CsbD; cl15799 1034836009884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836009885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034836009886 TPR repeat; Region: TPR_11; pfam13414 1034836009887 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1034836009888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034836009889 FeS/SAM binding site; other site 1034836009890 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1034836009891 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1034836009892 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1034836009893 metal ion-dependent adhesion site (MIDAS); other site 1034836009894 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1034836009895 metal ion-dependent adhesion site (MIDAS); other site 1034836009896 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1034836009897 Stage II sporulation protein; Region: SpoIID; pfam08486 1034836009898 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1034836009899 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1034836009900 hinge; other site 1034836009901 active site 1034836009902 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1034836009903 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1034836009904 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1034836009905 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1034836009906 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 1034836009907 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1034836009908 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1034836009909 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1034836009910 alpha subunit interaction interface [polypeptide binding]; other site 1034836009911 Walker A motif; other site 1034836009912 ATP binding site [chemical binding]; other site 1034836009913 Walker B motif; other site 1034836009914 inhibitor binding site; inhibition site 1034836009915 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1034836009916 ATP synthase; Region: ATP-synt; cl00365 1034836009917 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1034836009918 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1034836009919 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1034836009920 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1034836009921 beta subunit interaction interface [polypeptide binding]; other site 1034836009922 Walker A motif; other site 1034836009923 ATP binding site [chemical binding]; other site 1034836009924 Walker B motif; other site 1034836009925 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1034836009926 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1034836009927 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1034836009928 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1034836009929 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1034836009930 ATP synthase A chain; Region: ATP-synt_A; cl00413 1034836009931 ATP synthase I chain; Region: ATP_synt_I; cl09170 1034836009932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034836009933 active site 1034836009934 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1034836009935 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1034836009936 dimer interface [polypeptide binding]; other site 1034836009937 active site 1034836009938 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1034836009939 folate binding site [chemical binding]; other site 1034836009940 Protein of unknown function (DUF436); Region: DUF436; cl01860 1034836009941 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1034836009942 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1034836009943 Domain of unknown function DUF; Region: DUF204; pfam02659 1034836009944 Domain of unknown function DUF; Region: DUF204; pfam02659 1034836009945 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1034836009946 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1034836009947 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836009948 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 1034836009949 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1034836009950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836009951 S-adenosylmethionine binding site [chemical binding]; other site 1034836009952 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1034836009953 RF-1 domain; Region: RF-1; cl02875 1034836009954 RF-1 domain; Region: RF-1; cl02875 1034836009955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1034836009956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836009957 putative metal binding site [ion binding]; other site 1034836009958 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1034836009959 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1034836009960 DNA binding residues [nucleotide binding] 1034836009961 Trypanosomal VSG domain; Region: VSG_B; cl11958 1034836009962 Membrane transport protein; Region: Mem_trans; cl09117 1034836009963 malate dehydrogenase; Provisional; Region: PRK13529 1034836009964 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1034836009965 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1034836009966 NAD(P) binding site [chemical binding]; other site 1034836009967 thymidine kinase; Provisional; Region: PRK04296 1034836009968 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1034836009969 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1034836009970 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1034836009971 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1034836009972 RNA binding site [nucleotide binding]; other site 1034836009973 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1034836009974 multimer interface [polypeptide binding]; other site 1034836009975 Walker A motif; other site 1034836009976 ATP binding site [chemical binding]; other site 1034836009977 Walker B motif; other site 1034836009978 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1034836009979 putative active site [active] 1034836009980 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1034836009981 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1034836009982 hinge; other site 1034836009983 active site 1034836009984 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1034836009985 active site 1034836009986 intersubunit interactions; other site 1034836009987 catalytic residue [active] 1034836009988 hypothetical protein; Provisional; Region: PRK08185 1034836009989 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1034836009990 intersubunit interface [polypeptide binding]; other site 1034836009991 active site 1034836009992 zinc binding site [ion binding]; other site 1034836009993 Na+ binding site [ion binding]; other site 1034836009994 Response regulator receiver domain; Region: Response_reg; pfam00072 1034836009995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836009996 active site 1034836009997 phosphorylation site [posttranslational modification] 1034836009998 intermolecular recognition site; other site 1034836009999 dimerization interface [polypeptide binding]; other site 1034836010000 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1034836010001 CTP synthetase; Validated; Region: pyrG; PRK05380 1034836010002 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1034836010003 Catalytic site [active] 1034836010004 active site 1034836010005 UTP binding site [chemical binding]; other site 1034836010006 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1034836010007 active site 1034836010008 putative oxyanion hole; other site 1034836010009 catalytic triad [active] 1034836010010 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 1034836010011 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1034836010012 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1034836010013 Cysteine-rich domain; Region: CCG; pfam02754 1034836010014 Cysteine-rich domain; Region: CCG; pfam02754 1034836010015 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1034836010016 putative active site [active] 1034836010017 catalytic site [active] 1034836010018 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1034836010019 PLD-like domain; Region: PLDc_2; pfam13091 1034836010020 putative active site [active] 1034836010021 catalytic site [active] 1034836010022 UV-endonuclease UvdE; Region: UvdE; cl10036 1034836010023 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034836010024 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836010025 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1034836010026 Walker A/P-loop; other site 1034836010027 ATP binding site [chemical binding]; other site 1034836010028 Q-loop/lid; other site 1034836010029 ABC transporter signature motif; other site 1034836010030 Walker B; other site 1034836010031 D-loop; other site 1034836010032 H-loop/switch region; other site 1034836010033 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1034836010034 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1034836010035 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1034836010036 putative active site [active] 1034836010037 catalytic site [active] 1034836010038 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1034836010039 putative active site [active] 1034836010040 catalytic site [active] 1034836010041 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1034836010042 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1034836010043 nitrate reductase, beta subunit; Region: narH; TIGR01660 1034836010044 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1034836010045 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1034836010046 [4Fe-4S] binding site [ion binding]; other site 1034836010047 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034836010048 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034836010049 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034836010050 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1034836010051 molybdopterin cofactor binding site; other site 1034836010052 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1034836010053 ligand binding site [chemical binding]; other site 1034836010054 flexible hinge region; other site 1034836010055 YwiC-like protein; Region: YwiC; pfam14256 1034836010056 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1034836010057 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1034836010058 ligand binding site [chemical binding]; other site 1034836010059 flexible hinge region; other site 1034836010060 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1034836010061 putative switch regulator; other site 1034836010062 non-specific DNA interactions [nucleotide binding]; other site 1034836010063 DNA binding site [nucleotide binding] 1034836010064 sequence specific DNA binding site [nucleotide binding]; other site 1034836010065 putative cAMP binding site [chemical binding]; other site 1034836010066 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1034836010067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010068 putative substrate translocation pore; other site 1034836010069 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1034836010070 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1034836010071 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1034836010072 active site 1034836010073 HIGH motif; other site 1034836010074 KMSK motif region; other site 1034836010075 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1034836010076 tRNA binding surface [nucleotide binding]; other site 1034836010077 anticodon binding site; other site 1034836010078 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1034836010079 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1034836010080 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1034836010081 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1034836010082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034836010083 binding surface 1034836010084 TPR motif; other site 1034836010085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836010086 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1034836010087 Arginase family; Region: Arginase; cl00306 1034836010088 spermidine synthase; Provisional; Region: PRK00811 1034836010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836010090 Transglycosylase; Region: Transgly; cl07896 1034836010091 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1034836010092 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1034836010093 YwhD family; Region: YwhD; pfam08741 1034836010094 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1034836010095 active site 1034836010096 putative substrate binding region [chemical binding]; other site 1034836010097 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1034836010098 active site 1 [active] 1034836010099 dimer interface [polypeptide binding]; other site 1034836010100 hexamer interface [polypeptide binding]; other site 1034836010101 active site 2 [active] 1034836010102 Helix-turn-helix domains; Region: HTH; cl00088 1034836010103 Helix-turn-helix domains; Region: HTH; cl00088 1034836010104 amino acid transporter; Region: 2A0306; TIGR00909 1034836010105 Spore germination protein; Region: Spore_permease; cl15802 1034836010106 Spore germination protein; Region: Spore_permease; cl15802 1034836010107 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1034836010108 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1034836010109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034836010110 Zn2+ binding site [ion binding]; other site 1034836010111 Mg2+ binding site [ion binding]; other site 1034836010112 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1034836010113 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1034836010114 Helix-turn-helix domains; Region: HTH; cl00088 1034836010115 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 1034836010116 potential frameshift: common BLAST hit: gi|154687875|ref|YP_001423036.1| putative ABC transporter ATP-binding protein 1034836010117 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1034836010118 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034836010119 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1034836010120 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1034836010121 Helix-turn-helix domains; Region: HTH; cl00088 1034836010122 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1034836010123 putative dimerization interface [polypeptide binding]; other site 1034836010124 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1034836010125 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1034836010126 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1034836010127 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1034836010128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1034836010129 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1034836010130 putative NAD(P) binding site [chemical binding]; other site 1034836010131 putative active site [active] 1034836010132 transaminase; Reviewed; Region: PRK08068 1034836010133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836010134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836010135 homodimer interface [polypeptide binding]; other site 1034836010136 catalytic residue [active] 1034836010137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010138 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034836010139 putative substrate translocation pore; other site 1034836010140 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1034836010141 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836010142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1034836010143 classical (c) SDRs; Region: SDR_c; cd05233 1034836010144 NAD(P) binding site [chemical binding]; other site 1034836010145 active site 1034836010146 Cupin domain; Region: Cupin_2; cl09118 1034836010147 Cupin domain; Region: Cupin_2; cl09118 1034836010148 Prephenate dehydratase; Region: PDT; pfam00800 1034836010149 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836010150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010151 putative substrate translocation pore; other site 1034836010152 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1034836010153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010154 putative substrate translocation pore; other site 1034836010155 S-methylmethionine transporter; Provisional; Region: PRK11387 1034836010156 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1034836010157 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1034836010158 putative metal binding site [ion binding]; other site 1034836010159 putative dimer interface [polypeptide binding]; other site 1034836010160 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1034836010161 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1034836010162 Glutamate binding site [chemical binding]; other site 1034836010163 homodimer interface [polypeptide binding]; other site 1034836010164 NAD binding site [chemical binding]; other site 1034836010165 catalytic residues [active] 1034836010166 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1034836010167 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1034836010168 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1034836010169 NAD(P) binding site [chemical binding]; other site 1034836010170 Cupin domain; Region: Cupin_2; cl09118 1034836010171 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1034836010172 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1034836010173 NADP binding site [chemical binding]; other site 1034836010174 active site 1034836010175 putative substrate binding site [chemical binding]; other site 1034836010176 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1034836010177 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1034836010178 NAD binding site [chemical binding]; other site 1034836010179 substrate binding site [chemical binding]; other site 1034836010180 homodimer interface [polypeptide binding]; other site 1034836010181 active site 1034836010182 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1034836010183 substrate binding site; other site 1034836010184 tetramer interface; other site 1034836010185 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1034836010186 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034836010187 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1034836010188 ligand binding site; other site 1034836010189 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1034836010190 NeuB family; Region: NeuB; cl00496 1034836010191 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1034836010192 NeuB binding interface [polypeptide binding]; other site 1034836010193 putative substrate binding site [chemical binding]; other site 1034836010194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034836010195 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1034836010196 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1034836010197 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1034836010198 inhibitor-cofactor binding pocket; inhibition site 1034836010199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836010200 catalytic residue [active] 1034836010201 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1034836010202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034836010203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836010204 active site 1034836010205 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1034836010206 Protein of unknown function (DUF423); Region: DUF423; cl01008 1034836010207 Permease family; Region: Xan_ur_permease; pfam00860 1034836010208 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1034836010209 ligand binding site [chemical binding]; other site 1034836010210 active site 1034836010211 UGI interface [polypeptide binding]; other site 1034836010212 catalytic site [active] 1034836010213 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034836010214 active site 1034836010215 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1034836010216 dimer interface [polypeptide binding]; other site 1034836010217 substrate binding site [chemical binding]; other site 1034836010218 ATP binding site [chemical binding]; other site 1034836010219 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1034836010220 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1034836010221 substrate binding [chemical binding]; other site 1034836010222 active site 1034836010223 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1034836010224 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1034836010225 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836010226 active site turn [active] 1034836010227 phosphorylation site [posttranslational modification] 1034836010228 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836010229 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1034836010230 CAT RNA binding domain; Region: CAT_RBD; cl03904 1034836010231 PRD domain; Region: PRD; cl15445 1034836010232 PRD domain; Region: PRD; cl15445 1034836010233 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1034836010234 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1034836010235 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1034836010236 putative active site [active] 1034836010237 catalytic triad [active] 1034836010238 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1034836010239 PA/protease domain interface [polypeptide binding]; other site 1034836010240 putative integrin binding motif; other site 1034836010241 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1034836010242 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1034836010243 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1034836010244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034836010245 Predicted transcriptional regulator [Transcription]; Region: COG2378 1034836010246 Helix-turn-helix domains; Region: HTH; cl00088 1034836010247 WYL domain; Region: WYL; cl14852 1034836010248 short chain dehydrogenase; Provisional; Region: PRK06523 1034836010249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836010250 NAD(P) binding site [chemical binding]; other site 1034836010251 active site 1034836010252 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1034836010253 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1034836010254 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1034836010255 dimer interface [polypeptide binding]; other site 1034836010256 FMN binding site [chemical binding]; other site 1034836010257 NADPH bind site [chemical binding]; other site 1034836010258 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1034836010259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1034836010260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836010261 Coenzyme A binding pocket [chemical binding]; other site 1034836010262 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1034836010263 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1034836010264 Subunit I/III interface [polypeptide binding]; other site 1034836010265 Subunit III/IV interface [polypeptide binding]; other site 1034836010266 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1034836010267 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1034836010268 D-pathway; other site 1034836010269 Putative ubiquinol binding site [chemical binding]; other site 1034836010270 Low-spin heme (heme b) binding site [chemical binding]; other site 1034836010271 Putative water exit pathway; other site 1034836010272 Binuclear center (heme o3/CuB) [ion binding]; other site 1034836010273 K-pathway; other site 1034836010274 Putative proton exit pathway; other site 1034836010275 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1034836010276 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1034836010277 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1034836010278 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1034836010279 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1034836010280 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1034836010281 galactokinase; Provisional; Region: PRK05322 1034836010282 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1034836010283 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034836010284 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034836010285 GtrA-like protein; Region: GtrA; cl00971 1034836010286 Helix-turn-helix domains; Region: HTH; cl00088 1034836010287 Uso1 / p115 like vesicle tethering protein, head region; Region: Uso1_p115_head; pfam04869 1034836010288 Anti-repressor SinI; Region: SinI; pfam08671 1034836010289 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1034836010290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836010291 S-adenosylmethionine binding site [chemical binding]; other site 1034836010292 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1034836010293 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1034836010294 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1034836010295 catalytic residues [active] 1034836010296 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1034836010297 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1034836010298 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1034836010299 Imelysin; Region: Peptidase_M75; cl09159 1034836010300 Iron permease FTR1 family; Region: FTR1; cl00475 1034836010301 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1034836010302 thiamine phosphate binding site [chemical binding]; other site 1034836010303 active site 1034836010304 pyrophosphate binding site [ion binding]; other site 1034836010305 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1034836010306 substrate binding site [chemical binding]; other site 1034836010307 multimerization interface [polypeptide binding]; other site 1034836010308 ATP binding site [chemical binding]; other site 1034836010309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034836010310 Helix-turn-helix domains; Region: HTH; cl00088 1034836010311 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1034836010312 putative dimerization interface [polypeptide binding]; other site 1034836010313 LrgA family; Region: LrgA; cl00608 1034836010314 LrgB-like family; Region: LrgB; cl00596 1034836010315 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1034836010316 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1034836010317 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034836010318 DNA binding residues [nucleotide binding] 1034836010319 dimer interface [polypeptide binding]; other site 1034836010320 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1034836010321 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1034836010322 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1034836010323 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1034836010324 putative RNA binding site [nucleotide binding]; other site 1034836010325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836010326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836010327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034836010328 active site 1034836010329 metal binding site [ion binding]; metal-binding site 1034836010330 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1034836010331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836010332 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1034836010333 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1034836010334 active site 1034836010335 catalytic residues [active] 1034836010336 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1034836010337 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1034836010338 Ligand binding site; other site 1034836010339 metal-binding site 1034836010340 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034836010341 synthetase active site [active] 1034836010342 NTP binding site [chemical binding]; other site 1034836010343 metal binding site [ion binding]; metal-binding site 1034836010344 UbiA prenyltransferase family; Region: UbiA; cl00337 1034836010345 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1034836010346 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1034836010347 AMP-binding enzyme; Region: AMP-binding; cl15778 1034836010348 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1034836010349 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034836010350 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1034836010351 DltD N-terminal region; Region: DltD_N; pfam04915 1034836010352 DltD central region; Region: DltD_M; pfam04918 1034836010353 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1034836010354 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1034836010355 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1034836010356 homodimer interface [polypeptide binding]; other site 1034836010357 substrate-cofactor binding pocket; other site 1034836010358 catalytic residue [active] 1034836010359 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1034836010360 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1034836010361 NAD binding site [chemical binding]; other site 1034836010362 sugar binding site [chemical binding]; other site 1034836010363 divalent metal binding site [ion binding]; other site 1034836010364 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836010365 dimer interface [polypeptide binding]; other site 1034836010366 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1034836010367 methionine cluster; other site 1034836010368 active site 1034836010369 phosphorylation site [posttranslational modification] 1034836010370 metal binding site [ion binding]; metal-binding site 1034836010371 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1034836010372 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836010373 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1034836010374 active site 1034836010375 P-loop; other site 1034836010376 phosphorylation site [posttranslational modification] 1034836010377 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034836010378 Helix-turn-helix domains; Region: HTH; cl00088 1034836010379 Helix-turn-helix domains; Region: HTH; cl00088 1034836010380 PRD domain; Region: PRD; cl15445 1034836010381 PRD domain; Region: PRD; cl15445 1034836010382 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034836010383 active site 1034836010384 P-loop; other site 1034836010385 phosphorylation site [posttranslational modification] 1034836010386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034836010387 active site 1034836010388 phosphorylation site [posttranslational modification] 1034836010389 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1034836010390 active site 1034836010391 DNA binding site [nucleotide binding] 1034836010392 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034836010393 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836010394 ABC-ATPase subunit interface; other site 1034836010395 dimer interface [polypeptide binding]; other site 1034836010396 putative PBP binding regions; other site 1034836010397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034836010398 ABC-ATPase subunit interface; other site 1034836010399 dimer interface [polypeptide binding]; other site 1034836010400 putative PBP binding regions; other site 1034836010401 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034836010402 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034836010403 intersubunit interface [polypeptide binding]; other site 1034836010404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836010405 dimerization interface [polypeptide binding]; other site 1034836010406 putative DNA binding site [nucleotide binding]; other site 1034836010407 putative Zn2+ binding site [ion binding]; other site 1034836010408 arsenical pump membrane protein; Provisional; Region: PRK15445 1034836010409 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1034836010410 transmembrane helices; other site 1034836010411 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1034836010412 active site 1034836010413 P-loop; other site 1034836010414 phosphorylation site [posttranslational modification] 1034836010415 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1034836010416 active site 1034836010417 methionine cluster; other site 1034836010418 phosphorylation site [posttranslational modification] 1034836010419 metal binding site [ion binding]; metal-binding site 1034836010420 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1034836010421 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836010422 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034836010423 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1034836010424 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1034836010425 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1034836010426 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1034836010427 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1034836010428 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1034836010429 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1034836010430 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1034836010431 tetramer interface [polypeptide binding]; other site 1034836010432 heme binding pocket [chemical binding]; other site 1034836010433 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1034836010434 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1034836010435 active site 1034836010436 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1034836010437 Na binding site [ion binding]; other site 1034836010438 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1034836010439 putative substrate binding site [chemical binding]; other site 1034836010440 putative ATP binding site [chemical binding]; other site 1034836010441 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1034836010442 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836010443 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 1034836010444 Walker A/P-loop; other site 1034836010445 ATP binding site [chemical binding]; other site 1034836010446 Q-loop/lid; other site 1034836010447 ABC transporter signature motif; other site 1034836010448 Walker B; other site 1034836010449 D-loop; other site 1034836010450 H-loop/switch region; other site 1034836010451 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1034836010452 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1034836010453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836010454 ATP binding site [chemical binding]; other site 1034836010455 Q-loop/lid; other site 1034836010456 ABC transporter signature motif; other site 1034836010457 Walker B; other site 1034836010458 D-loop; other site 1034836010459 H-loop/switch region; other site 1034836010460 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1034836010461 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1034836010462 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1034836010463 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1034836010464 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1034836010465 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1034836010466 putative active site [active] 1034836010467 putative metal binding site [ion binding]; other site 1034836010468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1034836010469 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1034836010470 Walker A/P-loop; other site 1034836010471 ATP binding site [chemical binding]; other site 1034836010472 Q-loop/lid; other site 1034836010473 ABC transporter signature motif; other site 1034836010474 Walker B; other site 1034836010475 D-loop; other site 1034836010476 H-loop/switch region; other site 1034836010477 TOBE domain; Region: TOBE_2; cl01440 1034836010478 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1034836010479 Helix-turn-helix domains; Region: HTH; cl00088 1034836010480 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836010481 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836010482 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836010483 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1034836010484 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1034836010485 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1034836010486 UDP-glucose 4-epimerase; Region: PLN02240 1034836010487 NAD binding site [chemical binding]; other site 1034836010488 homodimer interface [polypeptide binding]; other site 1034836010489 active site 1034836010490 substrate binding site [chemical binding]; other site 1034836010491 peptidase T; Region: peptidase-T; TIGR01882 1034836010492 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1034836010493 metal binding site [ion binding]; metal-binding site 1034836010494 dimer interface [polypeptide binding]; other site 1034836010495 Scramblase; Region: Scramblase; cl02043 1034836010496 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1034836010497 substrate binding site [chemical binding]; other site 1034836010498 THF binding site; other site 1034836010499 zinc-binding site [ion binding]; other site 1034836010500 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1034836010501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836010502 S-adenosylmethionine binding site [chemical binding]; other site 1034836010503 nucleoside transporter; Region: nupC; TIGR00804 1034836010504 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034836010505 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034836010506 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1034836010507 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1034836010508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836010509 Q-loop/lid; other site 1034836010510 ABC transporter signature motif; other site 1034836010511 Walker B; other site 1034836010512 H-loop/switch region; other site 1034836010513 hydroperoxidase II; Provisional; Region: katE; PRK11249 1034836010514 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1034836010515 tetramer interface [polypeptide binding]; other site 1034836010516 heme binding pocket [chemical binding]; other site 1034836010517 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1034836010518 domain interactions; other site 1034836010519 Citrate transporter; Region: CitMHS; pfam03600 1034836010520 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1034836010521 transmembrane helices; other site 1034836010522 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1034836010523 active site 1034836010524 active site 1034836010525 catalytic residues [active] 1034836010526 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1034836010527 CAT RNA binding domain; Region: CAT_RBD; cl03904 1034836010528 PRD domain; Region: PRD; cl15445 1034836010529 PRD domain; Region: PRD; cl15445 1034836010530 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1034836010531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010532 putative substrate translocation pore; other site 1034836010533 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1034836010534 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034836010535 ATP binding site [chemical binding]; other site 1034836010536 Mg++ binding site [ion binding]; other site 1034836010537 motif III; other site 1034836010538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034836010539 nucleotide binding region [chemical binding]; other site 1034836010540 DbpA RNA binding domain; Region: DbpA; pfam03880 1034836010541 YxiJ-like protein; Region: YxiJ; pfam14176 1034836010542 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1034836010543 Pectate lyase; Region: Pec_lyase_C; cl01593 1034836010544 EamA-like transporter family; Region: EamA; cl01037 1034836010545 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1034836010546 EamA-like transporter family; Region: EamA; cl01037 1034836010547 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1034836010548 Ligand Binding Site [chemical binding]; other site 1034836010549 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034836010550 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1034836010551 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034836010552 active site turn [active] 1034836010553 phosphorylation site [posttranslational modification] 1034836010554 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1034836010555 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1034836010556 HPr interaction site; other site 1034836010557 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034836010558 active site 1034836010559 phosphorylation site [posttranslational modification] 1034836010560 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1034836010561 putative active site [active] 1034836010562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836010563 cofactor binding site; other site 1034836010564 DNA binding site [nucleotide binding] 1034836010565 substrate interaction site [chemical binding]; other site 1034836010566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836010567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1034836010568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1034836010569 Z1 domain; Region: Z1; pfam10593 1034836010570 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1034836010571 potential frameshift: common BLAST hit: gi|308175646|ref|YP_003922351.1| AIPR protein 1034836010572 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1034836010573 substrate binding site [chemical binding]; other site 1034836010574 active site 1034836010575 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944 1034836010576 RNA binding site [nucleotide binding]; other site 1034836010577 hexamer interface [polypeptide binding]; other site 1034836010578 Histidine-zinc binding site [chemical binding]; other site 1034836010579 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1034836010580 active sites [active] 1034836010581 tetramer interface [polypeptide binding]; other site 1034836010582 urocanate hydratase; Provisional; Region: PRK05414 1034836010583 imidazolonepropionase; Validated; Region: PRK09356 1034836010584 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1034836010585 active site 1034836010586 Arginase family; Region: Arginase; cl00306 1034836010587 S-methylmethionine transporter; Provisional; Region: PRK11387 1034836010588 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1034836010589 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1034836010590 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1034836010591 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1034836010592 nucleoside transporter; Region: nupC; TIGR00804 1034836010593 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034836010594 Nucleoside recognition; Region: Gate; cl00486 1034836010595 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034836010596 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1034836010597 intersubunit interface [polypeptide binding]; other site 1034836010598 active site 1034836010599 catalytic residue [active] 1034836010600 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1034836010601 Helix-turn-helix domains; Region: HTH; cl00088 1034836010602 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1034836010603 sugar phosphate phosphatase; Provisional; Region: PRK10513 1034836010604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836010605 active site 1034836010606 motif I; other site 1034836010607 motif II; other site 1034836010608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034836010609 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1034836010610 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034836010611 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1034836010612 putative ligand binding residues [chemical binding]; other site 1034836010613 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1034836010614 FtsX-like permease family; Region: FtsX; cl15850 1034836010615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034836010616 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1034836010617 Walker A/P-loop; other site 1034836010618 ATP binding site [chemical binding]; other site 1034836010619 Q-loop/lid; other site 1034836010620 ABC transporter signature motif; other site 1034836010621 Walker B; other site 1034836010622 D-loop; other site 1034836010623 H-loop/switch region; other site 1034836010624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1034836010625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836010626 ATP binding site [chemical binding]; other site 1034836010627 Mg2+ binding site [ion binding]; other site 1034836010628 G-X-G motif; other site 1034836010629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836010630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836010631 active site 1034836010632 phosphorylation site [posttranslational modification] 1034836010633 intermolecular recognition site; other site 1034836010634 dimerization interface [polypeptide binding]; other site 1034836010635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836010636 DNA binding site [nucleotide binding] 1034836010637 hypothetical protein; Provisional; Region: PRK08185 1034836010638 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1034836010639 intersubunit interface [polypeptide binding]; other site 1034836010640 active site 1034836010641 zinc binding site [ion binding]; other site 1034836010642 Na+ binding site [ion binding]; other site 1034836010643 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1034836010644 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1034836010645 Metal-binding active site; metal-binding site 1034836010646 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1034836010647 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1034836010648 DNA interaction; other site 1034836010649 Metal-binding active site; metal-binding site 1034836010650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1034836010651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836010652 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1034836010653 Glucuronate isomerase; Region: UxaC; cl00829 1034836010654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010656 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1034836010657 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1034836010658 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1034836010659 PYR/PP interface [polypeptide binding]; other site 1034836010660 dimer interface [polypeptide binding]; other site 1034836010661 TPP binding site [chemical binding]; other site 1034836010662 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1034836010663 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1034836010664 TPP-binding site; other site 1034836010665 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034836010666 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1034836010667 substrate binding site [chemical binding]; other site 1034836010668 ATP binding site [chemical binding]; other site 1034836010669 KduI/IolB family; Region: KduI; cl01508 1034836010670 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1034836010671 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836010672 tetrameric interface [polypeptide binding]; other site 1034836010673 NAD binding site [chemical binding]; other site 1034836010674 catalytic residues [active] 1034836010675 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034836010676 Helix-turn-helix domains; Region: HTH; cl00088 1034836010677 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034836010678 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1034836010679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836010680 active site 1034836010681 catalytic tetrad [active] 1034836010682 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1034836010683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010684 putative substrate translocation pore; other site 1034836010685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010686 heat shock protein 90; Provisional; Region: PRK05218 1034836010687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836010688 ATP binding site [chemical binding]; other site 1034836010689 Mg2+ binding site [ion binding]; other site 1034836010690 G-X-G motif; other site 1034836010691 short chain dehydrogenase; Validated; Region: PRK08589 1034836010692 classical (c) SDRs; Region: SDR_c; cd05233 1034836010693 NAD(P) binding site [chemical binding]; other site 1034836010694 active site 1034836010695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034836010696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836010697 active site 1034836010698 phosphorylation site [posttranslational modification] 1034836010699 intermolecular recognition site; other site 1034836010700 dimerization interface [polypeptide binding]; other site 1034836010701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034836010702 DNA binding residues [nucleotide binding] 1034836010703 dimerization interface [polypeptide binding]; other site 1034836010704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034836010705 Histidine kinase; Region: HisKA_3; pfam07730 1034836010706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1034836010707 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1034836010708 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1034836010709 putative di-iron ligands [ion binding]; other site 1034836010710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836010711 Helix-turn-helix domains; Region: HTH; cl00088 1034836010712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034836010713 Helix-turn-helix domains; Region: HTH; cl00088 1034836010714 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034836010715 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1034836010716 NAD(P) binding site [chemical binding]; other site 1034836010717 catalytic residues [active] 1034836010718 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1034836010719 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1034836010720 Trp docking motif [polypeptide binding]; other site 1034836010721 active site 1034836010722 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1034836010723 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836010724 putative DNA binding site [nucleotide binding]; other site 1034836010725 dimerization interface [polypeptide binding]; other site 1034836010726 putative Zn2+ binding site [ion binding]; other site 1034836010727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034836010728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010729 putative substrate translocation pore; other site 1034836010730 RDD family; Region: RDD; cl00746 1034836010731 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836010732 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034836010733 active site 1034836010734 metal binding site [ion binding]; metal-binding site 1034836010735 peroxiredoxin; Region: AhpC; TIGR03137 1034836010736 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1034836010737 dimer interface [polypeptide binding]; other site 1034836010738 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1034836010739 catalytic triad [active] 1034836010740 peroxidatic and resolving cysteines [active] 1034836010741 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1034836010742 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1034836010743 catalytic residue [active] 1034836010744 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1034836010745 catalytic residues [active] 1034836010746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034836010747 Major royal jelly protein; Region: MRJP; pfam03022 1034836010748 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1034836010749 Helix-turn-helix domains; Region: HTH; cl00088 1034836010750 WYL domain; Region: WYL; cl14852 1034836010751 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1034836010752 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1034836010753 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1034836010754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1034836010755 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1034836010756 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1034836010757 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1034836010758 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1034836010759 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1034836010760 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1034836010761 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1034836010762 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1034836010763 Ligand binding site; other site 1034836010764 metal-binding site 1034836010765 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1034836010766 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1034836010767 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1034836010768 Predicted membrane protein [Function unknown]; Region: COG4129 1034836010769 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1034836010770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836010771 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1034836010772 AAA ATPase domain; Region: AAA_15; pfam13175 1034836010773 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1034836010774 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1034836010775 putative active site [active] 1034836010776 putative metal-binding site [ion binding]; other site 1034836010777 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1034836010778 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1034836010779 YyzF-like protein; Region: YyzF; cl15733 1034836010780 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1034836010781 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1034836010782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034836010783 active site 1034836010784 catalytic tetrad [active] 1034836010785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034836010786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836010787 Coenzyme A binding pocket [chemical binding]; other site 1034836010788 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836010789 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1034836010790 Arginase family; Region: Arginase; cl00306 1034836010791 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1034836010792 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1034836010793 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034836010794 inhibitor-cofactor binding pocket; inhibition site 1034836010795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836010796 catalytic residue [active] 1034836010797 Predicted integral membrane protein [Function unknown]; Region: COG5658 1034836010798 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1034836010799 SdpI/YhfL protein family; Region: SdpI; pfam13630 1034836010800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034836010801 dimerization interface [polypeptide binding]; other site 1034836010802 putative DNA binding site [nucleotide binding]; other site 1034836010803 putative Zn2+ binding site [ion binding]; other site 1034836010804 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1034836010805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034836010806 Walker A motif; other site 1034836010807 ATP binding site [chemical binding]; other site 1034836010808 Walker B motif; other site 1034836010809 arginine finger; other site 1034836010810 Helix-turn-helix domains; Region: HTH; cl00088 1034836010811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010812 putative substrate translocation pore; other site 1034836010813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034836010814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836010815 dimerization interface [polypeptide binding]; other site 1034836010816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836010817 dimer interface [polypeptide binding]; other site 1034836010818 phosphorylation site [posttranslational modification] 1034836010819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836010820 ATP binding site [chemical binding]; other site 1034836010821 Mg2+ binding site [ion binding]; other site 1034836010822 G-X-G motif; other site 1034836010823 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836010824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836010825 active site 1034836010826 phosphorylation site [posttranslational modification] 1034836010827 intermolecular recognition site; other site 1034836010828 dimerization interface [polypeptide binding]; other site 1034836010829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836010830 DNA binding site [nucleotide binding] 1034836010831 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836010832 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836010833 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836010834 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1034836010835 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1034836010836 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1034836010837 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034836010838 protein binding site [polypeptide binding]; other site 1034836010839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1034836010840 YycH protein; Region: YycI; cl02015 1034836010841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1034836010842 YycH protein; Region: YycH; pfam07435 1034836010843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1034836010844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034836010845 dimerization interface [polypeptide binding]; other site 1034836010846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1034836010847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034836010848 dimer interface [polypeptide binding]; other site 1034836010849 phosphorylation site [posttranslational modification] 1034836010850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034836010851 ATP binding site [chemical binding]; other site 1034836010852 Mg2+ binding site [ion binding]; other site 1034836010853 G-X-G motif; other site 1034836010854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034836010855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034836010856 active site 1034836010857 phosphorylation site [posttranslational modification] 1034836010858 intermolecular recognition site; other site 1034836010859 dimerization interface [polypeptide binding]; other site 1034836010860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034836010861 DNA binding site [nucleotide binding] 1034836010862 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1034836010863 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034836010864 active site 1034836010865 replicative DNA helicase; Provisional; Region: PRK05748 1034836010866 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1034836010867 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1034836010868 Walker A motif; other site 1034836010869 ATP binding site [chemical binding]; other site 1034836010870 Walker B motif; other site 1034836010871 DNA binding loops [nucleotide binding] 1034836010872 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1034836010873 YycC-like protein; Region: YycC; pfam14174 1034836010874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034836010875 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1034836010876 Phosphotransferase enzyme family; Region: APH; pfam01636 1034836010877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034836010878 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1034836010879 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1034836010880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034836010881 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1034836010882 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1034836010883 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1034836010884 active site 1034836010885 substrate binding site [chemical binding]; other site 1034836010886 ATP binding site [chemical binding]; other site 1034836010887 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1034836010888 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1034836010889 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1034836010890 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1034836010891 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1034836010892 DHH family; Region: DHH; pfam01368 1034836010893 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1034836010894 Coat F domain; Region: Coat_F; cl15836 1034836010895 Helix-turn-helix domains; Region: HTH; cl00088 1034836010896 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1034836010897 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1034836010898 DHHA2 domain; Region: DHHA2; pfam02833 1034836010899 EamA-like transporter family; Region: EamA; cl01037 1034836010900 EamA-like transporter family; Region: EamA; cl01037 1034836010901 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1034836010902 active site 1034836010903 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1034836010904 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1034836010905 substrate binding [chemical binding]; other site 1034836010906 active site 1034836010907 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1034836010908 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1034836010909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836010910 DNA-binding site [nucleotide binding]; DNA binding site 1034836010911 FCD domain; Region: FCD; cl11656 1034836010912 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836010913 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034836010914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1034836010915 putative substrate translocation pore; other site 1034836010916 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1034836010917 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1034836010918 dimer interface [polypeptide binding]; other site 1034836010919 FMN binding site [chemical binding]; other site 1034836010920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836010921 Helix-turn-helix domains; Region: HTH; cl00088 1034836010922 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034836010923 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034836010924 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1034836010925 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034836010926 Helix-turn-helix domains; Region: HTH; cl00088 1034836010927 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1034836010928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836010929 Coenzyme A binding pocket [chemical binding]; other site 1034836010930 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1034836010931 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034836010932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034836010933 DNA-binding site [nucleotide binding]; DNA binding site 1034836010934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034836010935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034836010936 homodimer interface [polypeptide binding]; other site 1034836010937 catalytic residue [active] 1034836010938 EamA-like transporter family; Region: EamA; cl01037 1034836010939 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1034836010940 EamA-like transporter family; Region: EamA; cl01037 1034836010941 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1034836010942 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1034836010943 putative active site [active] 1034836010944 putative NTP binding site [chemical binding]; other site 1034836010945 putative nucleic acid binding site [nucleotide binding]; other site 1034836010946 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1034836010947 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1034836010948 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1034836010949 catalytic residues [active] 1034836010950 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1034836010951 CAAX protease self-immunity; Region: Abi; cl00558 1034836010952 benzoate transport; Region: 2A0115; TIGR00895 1034836010953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010954 putative substrate translocation pore; other site 1034836010955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034836010956 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1034836010957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034836010958 putative metal binding site [ion binding]; other site 1034836010959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034836010960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034836010961 DNA binding site [nucleotide binding] 1034836010962 domain linker motif; other site 1034836010963 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1034836010964 putative dimerization interface [polypeptide binding]; other site 1034836010965 putative ligand binding site [chemical binding]; other site 1034836010966 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1034836010967 active site 1034836010968 putative catalytic site [active] 1034836010969 DNA binding site [nucleotide binding] 1034836010970 putative phosphate binding site [ion binding]; other site 1034836010971 metal binding site A [ion binding]; metal-binding site 1034836010972 AP binding site [nucleotide binding]; other site 1034836010973 metal binding site B [ion binding]; metal-binding site 1034836010974 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1034836010975 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1034836010976 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1034836010977 DNA binding site [nucleotide binding] 1034836010978 active site 1034836010979 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1034836010980 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1034836010981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836010982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034836010983 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1034836010984 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1034836010985 dimer interface [polypeptide binding]; other site 1034836010986 ssDNA binding site [nucleotide binding]; other site 1034836010987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034836010988 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1034836010989 GTP-binding protein YchF; Reviewed; Region: PRK09601 1034836010990 YchF GTPase; Region: YchF; cd01900 1034836010991 G1 box; other site 1034836010992 GTP/Mg2+ binding site [chemical binding]; other site 1034836010993 Switch I region; other site 1034836010994 G2 box; other site 1034836010995 Switch II region; other site 1034836010996 G3 box; other site 1034836010997 G4 box; other site 1034836010998 G5 box; other site 1034836010999 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1034836011000 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1034836011001 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1034836011002 putative [4Fe-4S] binding site [ion binding]; other site 1034836011003 putative molybdopterin cofactor binding site [chemical binding]; other site 1034836011004 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1034836011005 molybdopterin cofactor binding site; other site 1034836011006 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 1034836011007 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1034836011008 Spore germination protein; Region: Spore_permease; cl15802 1034836011009 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1034836011010 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034836011011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034836011012 Coenzyme A binding pocket [chemical binding]; other site 1034836011013 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1034836011014 ParB-like partition proteins; Region: parB_part; TIGR00180 1034836011015 ParB-like nuclease domain; Region: ParBc; cl02129 1034836011016 KorB domain; Region: KorB; pfam08535 1034836011017 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1034836011018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1034836011019 ParB-like partition proteins; Region: parB_part; TIGR00180 1034836011020 ParB-like nuclease domain; Region: ParBc; cl02129 1034836011021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034836011022 S-adenosylmethionine binding site [chemical binding]; other site 1034836011023 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1034836011024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836011025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034836011026 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1034836011027 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1034836011028 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1034836011029 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1034836011030 G1 box; other site 1034836011031 GTP/Mg2+ binding site [chemical binding]; other site 1034836011032 Switch I region; other site 1034836011033 G2 box; other site 1034836011034 Switch II region; other site 1034836011035 G3 box; other site 1034836011036 G4 box; other site 1034836011037 G5 box; other site 1034836011038 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1034836011039 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1034836011040 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1034836011041 G-X-X-G motif; other site 1034836011042 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1034836011043 RxxxH motif; other site 1034836011044 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1034836011045 Ribonuclease P; Region: Ribonuclease_P; cl00457