-- dump date 20120504_133937 -- class Genbank::misc_feature -- table misc_feature_note -- id note 226900000001 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900000002 DNA binding residues [nucleotide binding] 226900000003 hypothetical protein; Region: PHA01548 226900000004 DNA polymerase; Provisional; Region: PHA02563 226900000005 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 226900000006 metal-binding site 226900000007 Helix-turn-helix domains; Region: HTH; cl00088 226900000008 HerA helicase [Replication, recombination, and repair]; Region: COG0433 226900000009 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 226900000010 Peptidase M15; Region: Peptidase_M15_3; cl01194 226900000011 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900000012 active site 226900000013 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900000014 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900000015 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 226900000016 hypothetical protein; Validated; Region: PRK06672 226900000017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000018 Walker A motif; other site 226900000019 ATP binding site [chemical binding]; other site 226900000020 Walker B motif; other site 226900000021 arginine finger; other site 226900000022 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 226900000023 DnaA box-binding interface [nucleotide binding]; other site 226900000024 DNA polymerase III subunit beta; Validated; Region: PRK05643 226900000025 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226900000026 putative DNA binding surface [nucleotide binding]; other site 226900000027 dimer interface [polypeptide binding]; other site 226900000028 beta-clamp/clamp loader binding surface; other site 226900000029 beta-clamp/translesion DNA polymerase binding surface; other site 226900000030 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 226900000031 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 226900000032 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 226900000033 Walker A/P-loop; other site 226900000034 ATP binding site [chemical binding]; other site 226900000035 Q-loop/lid; other site 226900000036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900000037 ABC transporter signature motif; other site 226900000038 Walker B; other site 226900000039 D-loop; other site 226900000040 H-loop/switch region; other site 226900000041 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226900000042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900000043 Mg2+ binding site [ion binding]; other site 226900000044 G-X-G motif; other site 226900000045 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226900000046 anchoring element; other site 226900000047 dimer interface [polypeptide binding]; other site 226900000048 ATP binding site [chemical binding]; other site 226900000049 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 226900000050 active site 226900000051 putative metal-binding site [ion binding]; other site 226900000052 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226900000053 DNA gyrase subunit A; Validated; Region: PRK05560 226900000054 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 226900000055 CAP-like domain; other site 226900000056 active site 226900000057 primary dimer interface [polypeptide binding]; other site 226900000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000064 YaaC-like Protein; Region: YaaC; pfam14175 226900000065 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 226900000066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 226900000067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 226900000068 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 226900000069 active site 226900000070 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900000071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900000072 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900000073 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 226900000074 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 226900000075 active site 226900000076 multimer interface [polypeptide binding]; other site 226900000077 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 226900000078 predicted active site [active] 226900000079 catalytic triad [active] 226900000080 seryl-tRNA synthetase; Provisional; Region: PRK05431 226900000081 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 226900000082 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 226900000083 dimer interface [polypeptide binding]; other site 226900000084 active site 226900000085 motif 1; other site 226900000086 motif 2; other site 226900000087 motif 3; other site 226900000088 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 226900000089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 226900000090 similar to Deoxyadenosine kinase; EC_number 2.7.1.76 226900000091 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 226900000092 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 226900000093 Substrate-binding site [chemical binding]; other site 226900000094 Substrate specificity [chemical binding]; other site 226900000095 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900000096 Isochorismatase family; Region: Isochorismatase; pfam00857 226900000097 catalytic triad [active] 226900000098 conserved cis-peptide bond; other site 226900000099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226900000100 nucleoside/Zn binding site; other site 226900000101 dimer interface [polypeptide binding]; other site 226900000102 catalytic motif [active] 226900000103 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 226900000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000105 Walker A motif; other site 226900000106 ATP binding site [chemical binding]; other site 226900000107 Walker B motif; other site 226900000108 arginine finger; other site 226900000109 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 226900000110 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 226900000111 recombination protein RecR; Reviewed; Region: recR; PRK00076 226900000112 RecR protein; Region: RecR; pfam02132 226900000113 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 226900000114 putative active site [active] 226900000115 putative metal-binding site [ion binding]; other site 226900000116 tetramer interface [polypeptide binding]; other site 226900000117 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 226900000118 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 226900000119 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 226900000120 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 226900000121 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 226900000122 homodimer interface [polypeptide binding]; other site 226900000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000124 catalytic residue [active] 226900000125 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 226900000126 thymidylate kinase; Validated; Region: tmk; PRK00698 226900000127 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 226900000128 TMP-binding site; other site 226900000129 ATP-binding site [chemical binding]; other site 226900000130 DNA polymerase III subunit delta'; Validated; Region: PRK08058 226900000131 PSP1 C-terminal conserved region; Region: PSP1; cl00770 226900000132 TSC-22/dip/bun family; Region: TSC22; cl01853 226900000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 226900000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000135 S-adenosylmethionine binding site [chemical binding]; other site 226900000136 Predicted methyltransferases [General function prediction only]; Region: COG0313 226900000137 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 226900000138 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900000139 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900000140 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 226900000141 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226900000142 active site 226900000143 HIGH motif; other site 226900000144 KMSKS motif; other site 226900000145 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226900000146 tRNA binding surface [nucleotide binding]; other site 226900000147 anticodon binding site; other site 226900000148 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 226900000149 dimer interface [polypeptide binding]; other site 226900000150 putative tRNA-binding site [nucleotide binding]; other site 226900000151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226900000152 active site 226900000153 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 226900000154 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 226900000155 putative active site [active] 226900000156 putative metal binding site [ion binding]; other site 226900000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900000158 YabG peptidase U57; Region: Peptidase_U57; cl05250 226900000159 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 226900000160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900000161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 226900000162 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 226900000163 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226900000164 pur operon repressor; Provisional; Region: PRK09213 226900000165 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 226900000166 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900000167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226900000168 homotrimer interaction site [polypeptide binding]; other site 226900000169 putative active site [active] 226900000170 SpoVG; Region: SpoVG; cl00915 226900000171 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 226900000172 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 226900000173 Substrate binding site; other site 226900000174 Mg++ binding site; other site 226900000175 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 226900000176 active site 226900000177 substrate binding site [chemical binding]; other site 226900000178 CoA binding site [chemical binding]; other site 226900000179 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 226900000180 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900000181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 226900000182 putative active site [active] 226900000183 catalytic residue [active] 226900000184 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 226900000185 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 226900000186 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 226900000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900000188 ATP binding site [chemical binding]; other site 226900000189 putative Mg++ binding site [ion binding]; other site 226900000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900000191 nucleotide binding region [chemical binding]; other site 226900000192 ATP-binding site [chemical binding]; other site 226900000193 TRCF domain; Region: TRCF; cl04088 226900000194 stage V sporulation protein T; Region: spore_V_T; TIGR02851 226900000195 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900000196 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900000197 MatE; Region: MatE; cl10513 226900000198 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 226900000199 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 226900000200 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900000201 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900000202 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900000203 RNA binding surface [nucleotide binding]; other site 226900000204 YabP family; Region: YabP; cl06766 226900000205 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 226900000206 Septum formation initiator; Region: DivIC; cl11433 226900000207 hypothetical protein; Provisional; Region: PRK08582 226900000208 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 226900000209 RNA binding site [nucleotide binding]; other site 226900000210 stage II sporulation protein E; Region: spore_II_E; TIGR02865 226900000211 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900000212 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 226900000213 Ligand Binding Site [chemical binding]; other site 226900000214 TilS substrate binding domain; Region: TilS; pfam09179 226900000215 B3/4 domain; Region: B3_4; cl11458 226900000216 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900000217 FtsH Extracellular; Region: FtsH_ext; pfam06480 226900000218 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 226900000219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000220 Walker A motif; other site 226900000221 ATP binding site [chemical binding]; other site 226900000222 Walker B motif; other site 226900000223 arginine finger; other site 226900000224 Peptidase family M41; Region: Peptidase_M41; pfam01434 226900000225 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 226900000226 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 226900000227 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 226900000228 dimerization interface [polypeptide binding]; other site 226900000229 domain crossover interface; other site 226900000230 redox-dependent activation switch; other site 226900000231 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 226900000232 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900000233 dimer interface [polypeptide binding]; other site 226900000234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000235 catalytic residue [active] 226900000236 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 226900000237 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 226900000238 chorismate binding enzyme; Region: Chorismate_bind; cl10555 226900000239 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 226900000240 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 226900000241 glutamine binding [chemical binding]; other site 226900000242 catalytic triad [active] 226900000243 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 226900000244 homodimer interface [polypeptide binding]; other site 226900000245 substrate-cofactor binding pocket; other site 226900000246 Aminotransferase class IV; Region: Aminotran_4; pfam01063 226900000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000248 catalytic residue [active] 226900000249 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 226900000250 dihydropteroate synthase; Region: DHPS; TIGR01496 226900000251 substrate binding pocket [chemical binding]; other site 226900000252 dimer interface [polypeptide binding]; other site 226900000253 inhibitor binding site; inhibition site 226900000254 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 226900000255 homooctamer interface [polypeptide binding]; other site 226900000256 active site 226900000257 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 226900000258 catalytic center binding site [active] 226900000259 ATP binding site [chemical binding]; other site 226900000260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900000261 non-specific DNA binding site [nucleotide binding]; other site 226900000262 salt bridge; other site 226900000263 sequence-specific DNA binding site [nucleotide binding]; other site 226900000264 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 226900000265 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226900000266 FMN binding site [chemical binding]; other site 226900000267 active site 226900000268 catalytic residues [active] 226900000269 substrate binding site [chemical binding]; other site 226900000270 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 226900000271 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 226900000272 dimer interface [polypeptide binding]; other site 226900000273 putative anticodon binding site; other site 226900000274 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 226900000275 motif 1; other site 226900000276 active site 226900000277 motif 2; other site 226900000278 motif 3; other site 226900000279 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 226900000280 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 226900000281 UvrB/uvrC motif; Region: UVR; pfam02151 226900000282 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 226900000283 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 226900000284 ADP binding site [chemical binding]; other site 226900000285 phosphagen binding site; other site 226900000286 substrate specificity loop; other site 226900000287 Clp protease ATP binding subunit; Region: clpC; CHL00095 226900000288 Clp amino terminal domain; Region: Clp_N; pfam02861 226900000289 Clp amino terminal domain; Region: Clp_N; pfam02861 226900000290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000291 Walker A motif; other site 226900000292 ATP binding site [chemical binding]; other site 226900000293 Walker B motif; other site 226900000294 arginine finger; other site 226900000295 UvrB/uvrC motif; Region: UVR; pfam02151 226900000296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000297 Walker A motif; other site 226900000298 ATP binding site [chemical binding]; other site 226900000299 Walker B motif; other site 226900000300 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 226900000301 DNA repair protein RadA; Provisional; Region: PRK11823 226900000302 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 226900000303 Walker A motif/ATP binding site; other site 226900000304 ATP binding site [chemical binding]; other site 226900000305 Walker B motif; other site 226900000306 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 226900000307 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900000308 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 226900000309 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 226900000310 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 226900000311 putative active site [active] 226900000312 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226900000313 substrate binding site; other site 226900000314 dimer interface; other site 226900000315 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 226900000316 homotrimer interaction site [polypeptide binding]; other site 226900000317 zinc binding site [ion binding]; other site 226900000318 CDP-binding sites; other site 226900000319 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 226900000320 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 226900000321 active site 226900000322 HIGH motif; other site 226900000323 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 226900000324 active site 226900000325 KMSKS motif; other site 226900000326 serine O-acetyltransferase; Region: cysE; TIGR01172 226900000327 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 226900000328 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226900000329 trimer interface [polypeptide binding]; other site 226900000330 active site 226900000331 substrate binding site [chemical binding]; other site 226900000332 CoA binding site [chemical binding]; other site 226900000333 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 226900000334 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 226900000335 active site 226900000336 HIGH motif; other site 226900000337 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 226900000338 KMSKS motif; other site 226900000339 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226900000340 tRNA binding surface [nucleotide binding]; other site 226900000341 anticodon binding site; other site 226900000342 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226900000343 active site 226900000344 metal binding site [ion binding]; metal-binding site 226900000345 dimerization interface [polypeptide binding]; other site 226900000346 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 226900000347 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 226900000348 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 226900000349 YacP-like NYN domain; Region: NYN_YacP; cl01491 226900000350 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 226900000351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900000352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 226900000353 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 226900000354 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 226900000355 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 226900000356 putative homodimer interface [polypeptide binding]; other site 226900000357 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900000358 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900000359 23S rRNA interface [nucleotide binding]; other site 226900000360 L7/L12 interface [polypeptide binding]; other site 226900000361 putative thiostrepton binding site; other site 226900000362 L25 interface [polypeptide binding]; other site 226900000363 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 226900000364 mRNA/rRNA interface [nucleotide binding]; other site 226900000365 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 226900000366 23S rRNA interface [nucleotide binding]; other site 226900000367 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 226900000368 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 226900000369 core dimer interface [polypeptide binding]; other site 226900000370 peripheral dimer interface [polypeptide binding]; other site 226900000371 L10 interface [polypeptide binding]; other site 226900000372 L11 interface [polypeptide binding]; other site 226900000373 putative EF-Tu interaction site [polypeptide binding]; other site 226900000374 putative EF-G interaction site [polypeptide binding]; other site 226900000375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000376 S-adenosylmethionine binding site [chemical binding]; other site 226900000377 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 226900000378 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 226900000379 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 226900000380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 226900000381 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 226900000382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 226900000383 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 226900000384 RPB10 interaction site [polypeptide binding]; other site 226900000385 RPB1 interaction site [polypeptide binding]; other site 226900000386 RPB11 interaction site [polypeptide binding]; other site 226900000387 RPB3 interaction site [polypeptide binding]; other site 226900000388 RPB12 interaction site [polypeptide binding]; other site 226900000389 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 226900000390 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 226900000391 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 226900000392 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 226900000393 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 226900000394 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 226900000395 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 226900000396 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 226900000397 G-loop; other site 226900000398 DNA binding site [nucleotide binding] 226900000399 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 226900000400 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 226900000401 S17 interaction site [polypeptide binding]; other site 226900000402 S8 interaction site; other site 226900000403 16S rRNA interaction site [nucleotide binding]; other site 226900000404 streptomycin interaction site [chemical binding]; other site 226900000405 23S rRNA interaction site [nucleotide binding]; other site 226900000406 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 226900000407 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 226900000408 similar to hypothetical protein 226900000409 elongation factor G; Reviewed; Region: PRK00007 226900000410 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 226900000411 G1 box; other site 226900000412 putative GEF interaction site [polypeptide binding]; other site 226900000413 GTP/Mg2+ binding site [chemical binding]; other site 226900000414 Switch I region; other site 226900000415 G2 box; other site 226900000416 G3 box; other site 226900000417 Switch II region; other site 226900000418 G4 box; other site 226900000419 G5 box; other site 226900000420 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 226900000421 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 226900000422 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 226900000423 elongation factor Tu; Reviewed; Region: PRK00049 226900000424 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 226900000425 G1 box; other site 226900000426 GEF interaction site [polypeptide binding]; other site 226900000427 GTP/Mg2+ binding site [chemical binding]; other site 226900000428 Switch I region; other site 226900000429 G2 box; other site 226900000430 G3 box; other site 226900000431 Switch II region; other site 226900000432 G4 box; other site 226900000433 G5 box; other site 226900000434 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 226900000435 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 226900000436 Antibiotic Binding Site [chemical binding]; other site 226900000437 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 226900000438 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 226900000439 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 226900000440 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 226900000441 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 226900000442 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 226900000443 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 226900000444 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 226900000445 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 226900000446 putative translocon binding site; other site 226900000447 protein-rRNA interface [nucleotide binding]; other site 226900000448 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 226900000449 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 226900000450 G-X-X-G motif; other site 226900000451 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 226900000452 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 226900000453 23S rRNA interface [nucleotide binding]; other site 226900000454 5S rRNA interface [nucleotide binding]; other site 226900000455 putative antibiotic binding site [chemical binding]; other site 226900000456 L25 interface [polypeptide binding]; other site 226900000457 L27 interface [polypeptide binding]; other site 226900000458 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 226900000459 putative translocon interaction site; other site 226900000460 signal recognition particle (SRP54) interaction site; other site 226900000461 L23 interface [polypeptide binding]; other site 226900000462 trigger factor interaction site; other site 226900000463 23S rRNA interface [nucleotide binding]; other site 226900000464 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 226900000465 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 226900000466 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 226900000467 KOW motif; Region: KOW; cl00354 226900000468 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 226900000469 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 226900000470 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 226900000471 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 226900000472 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 226900000473 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 226900000474 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226900000475 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226900000476 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 226900000477 5S rRNA interface [nucleotide binding]; other site 226900000478 L27 interface [polypeptide binding]; other site 226900000479 23S rRNA interface [nucleotide binding]; other site 226900000480 L5 interface [polypeptide binding]; other site 226900000481 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 226900000482 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 226900000483 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 226900000484 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 226900000485 23S rRNA binding site [nucleotide binding]; other site 226900000486 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 226900000487 similar to Protein translocase subunit SecY 226900000488 adenylate kinase; Reviewed; Region: adk; PRK00279 226900000489 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 226900000490 AMP-binding site [chemical binding]; other site 226900000491 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 226900000492 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900000493 active site 226900000494 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 226900000495 rRNA binding site [nucleotide binding]; other site 226900000496 predicted 30S ribosome binding site; other site 226900000497 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 226900000498 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 226900000499 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 226900000500 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 226900000501 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 226900000502 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 226900000503 alphaNTD - beta interaction site [polypeptide binding]; other site 226900000504 alphaNTD homodimer interface [polypeptide binding]; other site 226900000505 alphaNTD - beta' interaction site [polypeptide binding]; other site 226900000506 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 226900000507 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 226900000508 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 226900000509 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 226900000510 Walker A/P-loop; other site 226900000511 ATP binding site [chemical binding]; other site 226900000512 Q-loop/lid; other site 226900000513 ABC transporter signature motif; other site 226900000514 Walker B; other site 226900000515 D-loop; other site 226900000516 H-loop/switch region; other site 226900000517 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 226900000518 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 226900000519 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 226900000520 Walker A/P-loop; other site 226900000521 ATP binding site [chemical binding]; other site 226900000522 Q-loop/lid; other site 226900000523 ABC transporter signature motif; other site 226900000524 Walker B; other site 226900000525 D-loop; other site 226900000526 H-loop/switch region; other site 226900000527 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 226900000528 Cobalt transport protein; Region: CbiQ; cl00463 226900000529 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 226900000530 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 226900000531 dimerization interface 3.5A [polypeptide binding]; other site 226900000532 active site 226900000533 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 226900000534 23S rRNA interface [nucleotide binding]; other site 226900000535 L3 interface [polypeptide binding]; other site 226900000536 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 226900000537 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 226900000538 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900000539 active site 226900000540 metal binding site [ion binding]; metal-binding site 226900000541 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 226900000542 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 226900000543 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 226900000544 NodB motif; other site 226900000545 putative active site [active] 226900000546 putative catalytic site [active] 226900000547 Glycerate kinase family; Region: Gly_kinase; cl00841 226900000548 Arginase family; Region: Arginase; cl00306 226900000549 Uncharacterized conserved protein [Function unknown]; Region: COG1624 226900000550 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900000551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 226900000552 YbbR-like protein; Region: YbbR; pfam07949 226900000553 YbbR-like protein; Region: YbbR; pfam07949 226900000554 YbbR-like protein; Region: YbbR; pfam07949 226900000555 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 226900000556 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 226900000557 active site 226900000558 substrate binding site [chemical binding]; other site 226900000559 metal binding site [ion binding]; metal-binding site 226900000560 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 226900000561 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 226900000562 glutaminase active site [active] 226900000563 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226900000564 dimer interface [polypeptide binding]; other site 226900000565 active site 226900000566 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226900000567 dimer interface [polypeptide binding]; other site 226900000568 active site 226900000569 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 226900000570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 226900000571 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 226900000572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900000573 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 226900000574 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 226900000575 classical (c) SDRs; Region: SDR_c; cd05233 226900000576 NAD(P) binding site [chemical binding]; other site 226900000577 active site 226900000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000579 ABC-ATPase subunit interface; other site 226900000580 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 226900000581 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 226900000582 Walker A/P-loop; other site 226900000583 ATP binding site [chemical binding]; other site 226900000584 Q-loop/lid; other site 226900000585 ABC transporter signature motif; other site 226900000586 Walker B; other site 226900000587 D-loop; other site 226900000588 H-loop/switch region; other site 226900000589 NIL domain; Region: NIL; cl09633 226900000590 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900000591 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900000592 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 226900000593 putative NAD(P) binding site [chemical binding]; other site 226900000594 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 226900000595 FAD binding domain; Region: FAD_binding_4; pfam01565 226900000596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000597 putative substrate translocation pore; other site 226900000598 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 226900000599 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226900000600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000601 putative substrate translocation pore; other site 226900000602 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 226900000603 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 226900000604 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000606 dimer interface [polypeptide binding]; other site 226900000607 conserved gate region; other site 226900000608 putative PBP binding loops; other site 226900000609 ABC-ATPase subunit interface; other site 226900000610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900000611 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900000612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000613 dimer interface [polypeptide binding]; other site 226900000614 conserved gate region; other site 226900000615 putative PBP binding loops; other site 226900000616 ABC-ATPase subunit interface; other site 226900000617 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900000618 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900000619 Walker A/P-loop; other site 226900000620 ATP binding site [chemical binding]; other site 226900000621 Q-loop/lid; other site 226900000622 ABC transporter signature motif; other site 226900000623 Walker B; other site 226900000624 D-loop; other site 226900000625 H-loop/switch region; other site 226900000626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000627 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226900000628 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900000629 Walker A/P-loop; other site 226900000630 ATP binding site [chemical binding]; other site 226900000631 Q-loop/lid; other site 226900000632 ABC transporter signature motif; other site 226900000633 Walker B; other site 226900000634 D-loop; other site 226900000635 H-loop/switch region; other site 226900000636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000637 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000638 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000639 peptide binding site [polypeptide binding]; other site 226900000640 YusW-like protein; Region: YusW; pfam14039 226900000641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900000642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900000643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900000644 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000645 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000646 peptide binding site [polypeptide binding]; other site 226900000647 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000648 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000649 peptide binding site [polypeptide binding]; other site 226900000650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900000651 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900000652 active site 226900000653 catalytic tetrad [active] 226900000654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900000655 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 226900000656 Sugar transport protein; Region: Sugar_transport; pfam06800 226900000657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000658 dimer interface [polypeptide binding]; other site 226900000659 conserved gate region; other site 226900000660 putative PBP binding loops; other site 226900000661 ABC-ATPase subunit interface; other site 226900000662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900000663 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900000664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900000665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900000666 Helix-turn-helix domains; Region: HTH; cl00088 226900000667 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 226900000668 putative dimerization interface [polypeptide binding]; other site 226900000669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900000670 EamA-like transporter family; Region: EamA; cl01037 226900000671 YrzO-like protein; Region: YrzO; pfam14142 226900000672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226900000673 putative acyl-acceptor binding pocket; other site 226900000674 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900000675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900000676 DNA binding site [nucleotide binding] 226900000677 domain linker motif; other site 226900000678 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900000679 putative ligand binding site [chemical binding]; other site 226900000680 putative dimerization interface [polypeptide binding]; other site 226900000681 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900000682 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900000683 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900000684 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900000685 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900000686 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226900000687 active site 226900000688 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 226900000689 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 226900000690 NodB motif; other site 226900000691 putative active site [active] 226900000692 putative catalytic site [active] 226900000693 putative Zn binding site [ion binding]; other site 226900000694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 226900000695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226900000696 catalytic residue [active] 226900000697 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 226900000698 nucleotide binding site/active site [active] 226900000699 HIT family signature motif; other site 226900000700 catalytic residue [active] 226900000701 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900000702 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000703 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000704 ABC transporter; Region: ABC_tran_2; pfam12848 226900000705 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000706 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 226900000707 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 226900000708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900000709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000710 dimer interface [polypeptide binding]; other site 226900000711 conserved gate region; other site 226900000712 putative PBP binding loops; other site 226900000713 ABC-ATPase subunit interface; other site 226900000714 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900000715 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900000716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000717 dimer interface [polypeptide binding]; other site 226900000718 conserved gate region; other site 226900000719 putative PBP binding loops; other site 226900000720 ABC-ATPase subunit interface; other site 226900000721 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900000722 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900000723 Walker A/P-loop; other site 226900000724 ATP binding site [chemical binding]; other site 226900000725 Q-loop/lid; other site 226900000726 ABC transporter signature motif; other site 226900000727 Walker B; other site 226900000728 D-loop; other site 226900000729 H-loop/switch region; other site 226900000730 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000731 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 226900000732 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900000733 Walker A/P-loop; other site 226900000734 ATP binding site [chemical binding]; other site 226900000735 Q-loop/lid; other site 226900000736 ABC transporter signature motif; other site 226900000737 Walker B; other site 226900000738 D-loop; other site 226900000739 H-loop/switch region; other site 226900000740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900000742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900000743 active site 226900000744 motif I; other site 226900000745 motif II; other site 226900000746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900000747 motif II; other site 226900000748 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900000749 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000750 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000751 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000752 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000753 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000754 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 226900000755 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 226900000756 dimer interface [polypeptide binding]; other site 226900000757 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 226900000758 active site 226900000759 Fe binding site [ion binding]; other site 226900000760 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 226900000761 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 226900000762 Cupin domain; Region: Cupin_2; cl09118 226900000763 Amino acid permease; Region: AA_permease; cl00524 226900000764 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900000765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900000767 putative substrate translocation pore; other site 226900000768 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 226900000769 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226900000770 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900000771 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 226900000772 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900000773 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 226900000774 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900000775 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900000776 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900000777 ATP binding site [chemical binding]; other site 226900000778 Mg++ binding site [ion binding]; other site 226900000779 motif III; other site 226900000780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900000781 nucleotide binding region [chemical binding]; other site 226900000782 ATP-binding site [chemical binding]; other site 226900000783 UV-endonuclease UvdE; Region: UvdE; cl10036 226900000784 Rhomboid family; Region: Rhomboid; cl11446 226900000785 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 226900000786 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 226900000787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226900000788 alanine racemase; Reviewed; Region: alr; PRK00053 226900000789 active site 226900000790 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900000791 dimer interface [polypeptide binding]; other site 226900000792 substrate binding site [chemical binding]; other site 226900000793 catalytic residues [active] 226900000794 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 226900000795 PemK-like protein; Region: PemK; cl00995 226900000796 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 226900000797 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 226900000798 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 226900000799 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 226900000800 RNA binding site [nucleotide binding]; other site 226900000801 hypothetical protein; Provisional; Region: PRK04351 226900000802 SprT homologues; Region: SprT; cl01182 226900000803 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 226900000804 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 226900000805 Glycoprotease family; Region: Peptidase_M22; pfam00814 226900000806 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226900000807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900000808 Coenzyme A binding pocket [chemical binding]; other site 226900000809 UGMP family protein; Validated; Region: PRK09604 226900000810 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 226900000811 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900000812 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900000814 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000815 ABC transporter; Region: ABC_tran_2; pfam12848 226900000816 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900000817 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 226900000818 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 226900000819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900000820 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 226900000821 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900000822 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 226900000823 oligomerisation interface [polypeptide binding]; other site 226900000824 mobile loop; other site 226900000825 roof hairpin; other site 226900000826 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 226900000827 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 226900000828 ring oligomerisation interface [polypeptide binding]; other site 226900000829 ATP/Mg binding site [chemical binding]; other site 226900000830 stacking interactions; other site 226900000831 hinge regions; other site 226900000832 GMP synthase; Reviewed; Region: guaA; PRK00074 226900000833 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 226900000834 AMP/PPi binding site [chemical binding]; other site 226900000835 candidate oxyanion hole; other site 226900000836 catalytic triad [active] 226900000837 potential glutamine specificity residues [chemical binding]; other site 226900000838 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 226900000839 ATP Binding subdomain [chemical binding]; other site 226900000840 Ligand Binding sites [chemical binding]; other site 226900000841 Dimerization subdomain; other site 226900000842 Permease family; Region: Xan_ur_permease; cl00967 226900000843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900000845 active site 226900000846 phosphorylation site [posttranslational modification] 226900000847 intermolecular recognition site; other site 226900000848 dimerization interface [polypeptide binding]; other site 226900000849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900000850 DNA binding site [nucleotide binding] 226900000851 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226900000852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900000853 dimerization interface [polypeptide binding]; other site 226900000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900000855 dimer interface [polypeptide binding]; other site 226900000856 phosphorylation site [posttranslational modification] 226900000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900000858 ATP binding site [chemical binding]; other site 226900000859 Mg2+ binding site [ion binding]; other site 226900000860 G-X-G motif; other site 226900000861 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900000862 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900000863 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900000864 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 226900000865 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 226900000866 catalytic residues [active] 226900000867 Rhamnan synthesis protein F; Region: RgpF; cl01529 226900000868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000869 S-adenosylmethionine binding site [chemical binding]; other site 226900000870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000871 S-adenosylmethionine binding site [chemical binding]; other site 226900000872 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 226900000873 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900000874 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 226900000875 putative NAD(P) binding site [chemical binding]; other site 226900000876 active site 226900000877 putative substrate binding site [chemical binding]; other site 226900000878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000879 S-adenosylmethionine binding site [chemical binding]; other site 226900000880 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226900000881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900000882 active site 226900000883 EamA-like transporter family; Region: EamA; cl01037 226900000884 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900000885 EamA-like transporter family; Region: EamA; cl01037 226900000886 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 226900000887 AIR carboxylase; Region: AIRC; cl00310 226900000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900000889 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 226900000890 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900000891 adenylosuccinate lyase; Provisional; Region: PRK07492 226900000892 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 226900000893 tetramer interface [polypeptide binding]; other site 226900000894 active site 226900000895 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 226900000896 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 226900000897 ATP binding site [chemical binding]; other site 226900000898 active site 226900000899 substrate binding site [chemical binding]; other site 226900000900 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 226900000901 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 226900000902 putative active site [active] 226900000903 catalytic triad [active] 226900000904 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 226900000905 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 226900000906 dimerization interface [polypeptide binding]; other site 226900000907 ATP binding site [chemical binding]; other site 226900000908 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 226900000909 dimerization interface [polypeptide binding]; other site 226900000910 ATP binding site [chemical binding]; other site 226900000911 amidophosphoribosyltransferase; Provisional; Region: PRK06781 226900000912 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 226900000913 active site 226900000914 tetramer interface [polypeptide binding]; other site 226900000915 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900000916 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 226900000917 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 226900000918 dimerization interface [polypeptide binding]; other site 226900000919 putative ATP binding site [chemical binding]; other site 226900000920 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 226900000921 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 226900000922 active site 226900000923 substrate binding site [chemical binding]; other site 226900000924 cosubstrate binding site; other site 226900000925 catalytic site [active] 226900000926 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 226900000927 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 226900000928 purine monophosphate binding site [chemical binding]; other site 226900000929 dimer interface [polypeptide binding]; other site 226900000930 putative catalytic residues [active] 226900000931 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 226900000932 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 226900000933 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 226900000934 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 226900000935 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900000936 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 226900000937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 226900000938 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 226900000939 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 226900000940 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 226900000941 substrate binding site [chemical binding]; other site 226900000942 putative active site [active] 226900000943 dimer interface [polypeptide binding]; other site 226900000944 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 226900000945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900000946 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 226900000947 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 226900000948 nucleotide binding pocket [chemical binding]; other site 226900000949 K-X-D-G motif; other site 226900000950 catalytic site [active] 226900000951 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 226900000952 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 226900000953 Dimer interface [polypeptide binding]; other site 226900000954 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 226900000955 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900000956 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900000957 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 226900000958 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 226900000959 Glutamate binding site [chemical binding]; other site 226900000960 homodimer interface [polypeptide binding]; other site 226900000961 NAD binding site [chemical binding]; other site 226900000962 catalytic residues [active] 226900000963 Isochorismatase family; Region: Isochorismatase; pfam00857 226900000964 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900000965 catalytic triad [active] 226900000966 conserved cis-peptide bond; other site 226900000967 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 226900000968 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 226900000969 Walker A/P-loop; other site 226900000970 ATP binding site [chemical binding]; other site 226900000971 Q-loop/lid; other site 226900000972 ABC transporter signature motif; other site 226900000973 Walker B; other site 226900000974 D-loop; other site 226900000975 H-loop/switch region; other site 226900000976 NIL domain; Region: NIL; cl09633 226900000977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000978 dimer interface [polypeptide binding]; other site 226900000979 conserved gate region; other site 226900000980 ABC-ATPase subunit interface; other site 226900000981 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900000982 yiaA/B two helix domain; Region: YiaAB; cl01759 226900000983 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 226900000984 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 226900000985 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 226900000986 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 226900000987 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 226900000988 GatB domain; Region: GatB_Yqey; cl11497 226900000989 putative lipid kinase; Reviewed; Region: PRK13337 226900000990 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 226900000991 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900000992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900000993 motif II; other site 226900000994 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 226900000995 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900000996 inhibitor-cofactor binding pocket; inhibition site 226900000997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000998 catalytic residue [active] 226900000999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900001000 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 226900001001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001002 Walker A motif; other site 226900001003 ATP binding site [chemical binding]; other site 226900001004 Walker B motif; other site 226900001005 arginine finger; other site 226900001006 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900001007 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 226900001008 tetramerization interface [polypeptide binding]; other site 226900001009 NAD(P) binding site [chemical binding]; other site 226900001010 catalytic residues [active] 226900001011 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226900001012 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 226900001013 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900001014 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 226900001015 putative active site [active] 226900001016 putative metal binding site [ion binding]; other site 226900001017 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900001018 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900001019 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900001020 TRAM domain; Region: TRAM; cl01282 226900001021 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 226900001022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001023 S-adenosylmethionine binding site [chemical binding]; other site 226900001024 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 226900001025 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226900001026 FMN binding site [chemical binding]; other site 226900001027 active site 226900001028 catalytic residues [active] 226900001029 substrate binding site [chemical binding]; other site 226900001030 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 226900001031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 226900001032 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 226900001033 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 226900001034 Protein of unknown function DUF45; Region: DUF45; cl00636 226900001035 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 226900001036 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226900001037 active site 226900001038 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900001039 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 226900001040 amidohydrolase; Region: amidohydrolases; TIGR01891 226900001041 metal binding site [ion binding]; metal-binding site 226900001042 putative dimer interface [polypeptide binding]; other site 226900001043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001044 S-adenosylmethionine binding site [chemical binding]; other site 226900001045 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 226900001046 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 226900001047 catalytic residue [active] 226900001048 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 226900001049 catalytic residues [active] 226900001050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001051 peroxiredoxin; Region: AhpC; TIGR03137 226900001052 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 226900001053 dimer interface [polypeptide binding]; other site 226900001054 decamer (pentamer of dimers) interface [polypeptide binding]; other site 226900001055 catalytic triad [active] 226900001056 peroxidatic and resolving cysteines [active] 226900001057 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900001058 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 226900001059 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 226900001060 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 226900001061 intersubunit interface [polypeptide binding]; other site 226900001062 active site 226900001063 Zn2+ binding site [ion binding]; other site 226900001064 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001065 ABC-ATPase subunit interface; other site 226900001066 dimer interface [polypeptide binding]; other site 226900001067 putative PBP binding regions; other site 226900001068 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001069 ABC-ATPase subunit interface; other site 226900001070 dimer interface [polypeptide binding]; other site 226900001071 putative PBP binding regions; other site 226900001072 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900001073 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900001074 putative ligand binding residues [chemical binding]; other site 226900001075 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900001076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900001078 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 226900001079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900001080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001081 dimer interface [polypeptide binding]; other site 226900001082 phosphorylation site [posttranslational modification] 226900001083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001084 ATP binding site [chemical binding]; other site 226900001085 Mg2+ binding site [ion binding]; other site 226900001086 G-X-G motif; other site 226900001087 Putative cyclase; Region: Cyclase; cl00814 226900001088 hypothetical protein; Provisional; Region: PRK06851 226900001089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001090 Walker A motif; other site 226900001091 ATP binding site [chemical binding]; other site 226900001092 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 226900001093 benzoate transport; Region: 2A0115; TIGR00895 226900001094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001095 putative substrate translocation pore; other site 226900001096 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900001097 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 226900001098 [2Fe-2S] cluster binding site [ion binding]; other site 226900001099 Fatty acid desaturase; Region: FA_desaturase; pfam00487 226900001100 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 226900001101 putative di-iron ligands [ion binding]; other site 226900001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001103 dimer interface [polypeptide binding]; other site 226900001104 conserved gate region; other site 226900001105 putative PBP binding loops; other site 226900001106 ABC-ATPase subunit interface; other site 226900001107 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226900001108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900001109 substrate binding pocket [chemical binding]; other site 226900001110 membrane-bound complex binding site; other site 226900001111 hinge residues; other site 226900001112 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900001113 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 226900001114 Walker A/P-loop; other site 226900001115 ATP binding site [chemical binding]; other site 226900001116 Q-loop/lid; other site 226900001117 ABC transporter signature motif; other site 226900001118 Walker B; other site 226900001119 D-loop; other site 226900001120 H-loop/switch region; other site 226900001121 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226900001122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900001123 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900001124 Arginine repressor [Transcription]; Region: ArgR; COG1438 226900001125 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226900001126 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226900001127 Amidinotransferase; Region: Amidinotransf; cl12043 226900001128 ornithine carbamoyltransferase; Validated; Region: PRK02102 226900001129 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900001130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001131 Amino acid permease; Region: AA_permease; cl00524 226900001132 carbamate kinase; Reviewed; Region: PRK12686 226900001133 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226900001134 putative substrate binding site [chemical binding]; other site 226900001135 nucleotide binding site [chemical binding]; other site 226900001136 nucleotide binding site [chemical binding]; other site 226900001137 homodimer interface [polypeptide binding]; other site 226900001138 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226900001139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900001140 ligand binding site [chemical binding]; other site 226900001141 flexible hinge region; other site 226900001142 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 226900001143 putative switch regulator; other site 226900001144 non-specific DNA interactions [nucleotide binding]; other site 226900001145 DNA binding site [nucleotide binding] 226900001146 sequence specific DNA binding site [nucleotide binding]; other site 226900001147 putative cAMP binding site [chemical binding]; other site 226900001148 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 226900001149 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 226900001150 FAD binding domain; Region: FAD_binding_4; pfam01565 226900001151 Berberine and berberine like; Region: BBE; pfam08031 226900001152 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900001153 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900001154 Ca binding site [ion binding]; other site 226900001155 active site 226900001156 catalytic site [active] 226900001157 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900001158 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 226900001159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001160 active site turn [active] 226900001161 phosphorylation site [posttranslational modification] 226900001162 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 226900001163 putative catalytic site [active] 226900001164 putative metal binding site [ion binding]; other site 226900001165 putative phosphate binding site [ion binding]; other site 226900001166 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900001167 Predicted membrane protein [Function unknown]; Region: COG1511 226900001168 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900001169 DNA topoisomerase III; Provisional; Region: PRK07726 226900001170 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226900001171 active site 226900001172 putative interdomain interaction site [polypeptide binding]; other site 226900001173 putative metal-binding site [ion binding]; other site 226900001174 putative nucleotide binding site [chemical binding]; other site 226900001175 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900001176 domain I; other site 226900001177 DNA binding groove [nucleotide binding] 226900001178 phosphate binding site [ion binding]; other site 226900001179 domain II; other site 226900001180 domain III; other site 226900001181 nucleotide binding site [chemical binding]; other site 226900001182 catalytic site [active] 226900001183 domain IV; other site 226900001184 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 226900001185 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 226900001186 substrate binding site [chemical binding]; other site 226900001187 multimerization interface [polypeptide binding]; other site 226900001188 ATP binding site [chemical binding]; other site 226900001189 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226900001190 thiamine phosphate binding site [chemical binding]; other site 226900001191 active site 226900001192 pyrophosphate binding site [ion binding]; other site 226900001193 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 226900001194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900001195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001196 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900001197 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900001198 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900001199 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900001200 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 226900001201 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 226900001202 putative NAD(P) binding site [chemical binding]; other site 226900001203 active site 226900001204 putative substrate binding site [chemical binding]; other site 226900001205 Domain of unknown function DUF77; Region: DUF77; cl00307 226900001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001207 dimer interface [polypeptide binding]; other site 226900001208 conserved gate region; other site 226900001209 putative PBP binding loops; other site 226900001210 ABC-ATPase subunit interface; other site 226900001211 NMT1/THI5 like; Region: NMT1; pfam09084 226900001212 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 226900001213 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900001214 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 226900001215 Walker A/P-loop; other site 226900001216 ATP binding site [chemical binding]; other site 226900001217 Q-loop/lid; other site 226900001218 ABC transporter signature motif; other site 226900001219 Walker B; other site 226900001220 D-loop; other site 226900001221 H-loop/switch region; other site 226900001222 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900001223 H-loop/switch region; other site 226900001224 Glyco_18 domain; Region: Glyco_18; smart00636 226900001225 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 226900001226 active site 226900001227 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 226900001228 Cellulose binding domain; Region: CBM_2; cl02709 226900001229 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 226900001230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900001231 catalytic residues [active] 226900001232 Helix-turn-helix domains; Region: HTH; cl00088 226900001233 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 226900001234 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900001235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001236 putative substrate translocation pore; other site 226900001237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001238 non-specific DNA binding site [nucleotide binding]; other site 226900001239 salt bridge; other site 226900001240 sequence-specific DNA binding site [nucleotide binding]; other site 226900001241 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 226900001242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001243 putative substrate translocation pore; other site 226900001244 Sulfatase; Region: Sulfatase; cl10460 226900001245 YesK-like protein; Region: YesK; pfam14150 226900001246 prolyl-tRNA synthetase; Provisional; Region: PRK08661 226900001247 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 226900001248 dimer interface [polypeptide binding]; other site 226900001249 motif 1; other site 226900001250 active site 226900001251 motif 2; other site 226900001252 motif 3; other site 226900001253 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 226900001254 anticodon binding site; other site 226900001255 zinc-binding site [ion binding]; other site 226900001256 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226900001257 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 226900001258 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 226900001259 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001260 putative metal binding site [ion binding]; other site 226900001261 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 226900001262 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001263 putative metal binding site [ion binding]; other site 226900001264 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 226900001265 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001266 putative metal binding site [ion binding]; other site 226900001267 Integral membrane protein TerC family; Region: TerC; cl10468 226900001268 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 226900001269 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 226900001270 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 226900001271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226900001272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001273 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900001274 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226900001275 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 226900001276 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900001277 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 226900001278 active site 226900001279 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 226900001280 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 226900001281 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 226900001282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001283 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900001284 EamA-like transporter family; Region: EamA; cl01037 226900001285 EamA-like transporter family; Region: EamA; cl01037 226900001286 YhhN-like protein; Region: YhhN; cl01505 226900001287 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900001288 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900001289 Catalytic site [active] 226900001290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900001291 binding surface 226900001292 TPR motif; other site 226900001293 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900001294 EamA-like transporter family; Region: EamA; cl01037 226900001295 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 226900001296 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 226900001297 calcium/proton exchanger (cax); Region: cax; TIGR00378 226900001298 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 226900001299 YfkD-like protein; Region: YfkD; pfam14167 226900001300 Radical SAM superfamily; Region: Radical_SAM; pfam04055 226900001301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900001302 FeS/SAM binding site; other site 226900001303 YfkB-like domain; Region: YfkB; pfam08756 226900001304 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 226900001305 Fumarase C-terminus; Region: Fumerase_C; cl00795 226900001306 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 226900001307 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 226900001308 NodB motif; other site 226900001309 active site 226900001310 catalytic site [active] 226900001311 Cd binding site [ion binding]; other site 226900001312 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900001313 endonuclease III; Region: ENDO3c; smart00478 226900001314 minor groove reading motif; other site 226900001315 helix-hairpin-helix signature motif; other site 226900001316 substrate binding pocket [chemical binding]; other site 226900001317 active site 226900001318 similar to tRNA (Uracil-5)-methyltransferase; EC_number 2.1.1.35 226900001319 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 226900001320 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 226900001321 dimerization interface 3.5A [polypeptide binding]; other site 226900001322 active site 226900001323 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 226900001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001325 Walker A motif; other site 226900001326 ATP binding site [chemical binding]; other site 226900001327 Walker B motif; other site 226900001328 arginine finger; other site 226900001329 Helix-turn-helix domains; Region: HTH; cl00088 226900001330 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 226900001331 similar to Arginine permease 226900001332 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 226900001333 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 226900001334 metal binding site [ion binding]; metal-binding site 226900001335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001336 non-specific DNA binding site [nucleotide binding]; other site 226900001337 salt bridge; other site 226900001338 sequence-specific DNA binding site [nucleotide binding]; other site 226900001339 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 226900001340 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 226900001341 Domain of unknown function DUF; Region: DUF204; pfam02659 226900001342 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 226900001343 Glutaminase; Region: Glutaminase; cl00907 226900001344 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 226900001345 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900001346 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001347 active site turn [active] 226900001348 phosphorylation site [posttranslational modification] 226900001349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900001350 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226900001351 Ligand binding site; other site 226900001352 Putative Catalytic site; other site 226900001353 DXD motif; other site 226900001354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900001355 active site 226900001356 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 226900001357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001358 NAD(P) binding site [chemical binding]; other site 226900001359 active site 226900001360 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226900001361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001363 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900001364 NAD(P) binding site [chemical binding]; other site 226900001365 active site 226900001366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900001367 active site 226900001368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900001369 active site 226900001370 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 226900001371 Pyruvate formate lyase 1; Region: PFL1; cd01678 226900001372 coenzyme A binding site [chemical binding]; other site 226900001373 active site 226900001374 catalytic residues [active] 226900001375 glycine loop; other site 226900001376 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 226900001377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900001378 FeS/SAM binding site; other site 226900001379 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 226900001380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226900001381 YfhE-like protein; Region: YfhE; pfam14152 226900001382 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900001383 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 226900001384 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 226900001385 active site 226900001386 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 226900001387 TIGR01777 family protein; Region: yfcH 226900001388 putative NAD(P) binding site [chemical binding]; other site 226900001389 putative active site [active] 226900001390 RecX family; Region: RecX; cl00936 226900001391 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 226900001392 YpzG-like protein; Region: YpzG; pfam14139 226900001393 Small acid-soluble spore protein K family; Region: SspK; cl11509 226900001394 WVELL protein; Region: WVELL; pfam14043 226900001395 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 226900001396 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 226900001397 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900001398 minor groove reading motif; other site 226900001399 helix-hairpin-helix signature motif; other site 226900001400 substrate binding pocket [chemical binding]; other site 226900001401 active site 226900001402 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 226900001403 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 226900001404 DNA binding and oxoG recognition site [nucleotide binding] 226900001405 YgaB-like protein; Region: YgaB; pfam14182 226900001406 Protein of unknown function (DUF402); Region: DUF402; cl00979 226900001407 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900001408 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900001409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900001410 Walker A/P-loop; other site 226900001411 ATP binding site [chemical binding]; other site 226900001412 Q-loop/lid; other site 226900001413 ABC transporter signature motif; other site 226900001414 Walker B; other site 226900001415 D-loop; other site 226900001416 H-loop/switch region; other site 226900001417 Predicted membrane protein [Function unknown]; Region: COG4129 226900001418 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 226900001419 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 226900001420 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 226900001421 active site 226900001422 dimer interface [polypeptide binding]; other site 226900001423 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 226900001424 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 226900001425 active site 226900001426 FMN binding site [chemical binding]; other site 226900001427 substrate binding site [chemical binding]; other site 226900001428 3Fe-4S cluster binding site [ion binding]; other site 226900001429 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 226900001430 domain_subunit interface; other site 226900001431 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 226900001432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900001433 inhibitor-cofactor binding pocket; inhibition site 226900001434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001435 catalytic residue [active] 226900001436 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 226900001437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900001438 Walker A/P-loop; other site 226900001439 ATP binding site [chemical binding]; other site 226900001440 Q-loop/lid; other site 226900001441 ABC transporter signature motif; other site 226900001442 Walker B; other site 226900001443 D-loop; other site 226900001444 H-loop/switch region; other site 226900001445 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 226900001446 Protein of unknown function (DUF990); Region: DUF990; cl01496 226900001447 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 226900001448 Protein of unknown function (DUF990); Region: DUF990; cl01496 226900001449 Ion channel; Region: Ion_trans_2; cl11596 226900001450 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 226900001451 catalytic triad [active] 226900001452 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900001453 metal binding site 2 [ion binding]; metal-binding site 226900001454 putative DNA binding helix; other site 226900001455 metal binding site 1 [ion binding]; metal-binding site 226900001456 dimer interface [polypeptide binding]; other site 226900001457 structural Zn2+ binding site [ion binding]; other site 226900001458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001459 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900001460 Coenzyme A binding pocket [chemical binding]; other site 226900001461 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 226900001462 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 226900001463 Domain of unknown function DUF28; Region: DUF28; cl00361 226900001464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900001465 nudix motif; other site 226900001466 Transglycosylase; Region: Transgly; cl07896 226900001467 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226900001468 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 226900001469 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 226900001470 4Fe-4S binding domain; Region: Fer4; cl02805 226900001471 stage II sporulation protein E; Region: spore_II_E; TIGR02865 226900001472 NlpC/P60 family; Region: NLPC_P60; cl11438 226900001473 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 226900001474 PAS fold; Region: PAS_4; pfam08448 226900001475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900001476 putative active site [active] 226900001477 heme pocket [chemical binding]; other site 226900001478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900001479 metal binding site [ion binding]; metal-binding site 226900001480 active site 226900001481 I-site; other site 226900001482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900001483 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 226900001484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900001485 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 226900001486 Uncharacterized conserved protein [Function unknown]; Region: COG2718 226900001487 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226900001488 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001489 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 226900001490 Leucine-rich repeats; other site 226900001491 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001492 Substrate binding site [chemical binding]; other site 226900001493 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001494 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001495 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001496 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001497 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001498 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001499 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001500 similar to Acetyltransferase; EC_number 2.3.1.- 226900001501 BCCT family transporter; Region: BCCT; cl00569 226900001502 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900001503 Collagenase; Region: Peptidase_M9; pfam01752 226900001504 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900001505 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900001506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 226900001507 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 226900001508 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 226900001509 Cache domain; Region: Cache_1; pfam02743 226900001510 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 226900001511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001512 dimerization interface [polypeptide binding]; other site 226900001513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001514 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900001515 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 226900001516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001518 ATP binding site [chemical binding]; other site 226900001519 Mg2+ binding site [ion binding]; other site 226900001520 G-X-G motif; other site 226900001521 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226900001522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001523 active site 226900001524 phosphorylation site [posttranslational modification] 226900001525 intermolecular recognition site; other site 226900001526 dimerization interface [polypeptide binding]; other site 226900001527 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 226900001528 Citrate transporter; Region: CitMHS; pfam03600 226900001529 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 226900001530 NosL; Region: NosL; cl01769 226900001531 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900001532 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 226900001533 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900001534 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900001535 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 226900001536 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 226900001537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900001538 Walker A/P-loop; other site 226900001539 ATP binding site [chemical binding]; other site 226900001540 Q-loop/lid; other site 226900001541 ABC transporter signature motif; other site 226900001542 Walker B; other site 226900001543 D-loop; other site 226900001544 H-loop/switch region; other site 226900001545 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 226900001546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001547 dimer interface [polypeptide binding]; other site 226900001548 conserved gate region; other site 226900001549 putative PBP binding loops; other site 226900001550 ABC-ATPase subunit interface; other site 226900001551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226900001552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900001553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001554 dimer interface [polypeptide binding]; other site 226900001555 conserved gate region; other site 226900001556 putative PBP binding loops; other site 226900001557 ABC-ATPase subunit interface; other site 226900001558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226900001559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900001560 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900001561 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 226900001562 active site 226900001563 metal binding site [ion binding]; metal-binding site 226900001564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001566 active site 226900001567 phosphorylation site [posttranslational modification] 226900001568 intermolecular recognition site; other site 226900001569 dimerization interface [polypeptide binding]; other site 226900001570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001571 DNA binding site [nucleotide binding] 226900001572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001573 dimer interface [polypeptide binding]; other site 226900001574 phosphorylation site [posttranslational modification] 226900001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001576 ATP binding site [chemical binding]; other site 226900001577 Mg2+ binding site [ion binding]; other site 226900001578 G-X-G motif; other site 226900001579 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226900001580 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 226900001581 putative active site [active] 226900001582 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 226900001583 Cache domain; Region: Cache_1; pfam02743 226900001584 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 226900001585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001586 dimerization interface [polypeptide binding]; other site 226900001587 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001588 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900001589 sensory histidine kinase DcuS; Provisional; Region: PRK11086 226900001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001591 ATP binding site [chemical binding]; other site 226900001592 Mg2+ binding site [ion binding]; other site 226900001593 G-X-G motif; other site 226900001594 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 226900001595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001596 active site 226900001597 phosphorylation site [posttranslational modification] 226900001598 intermolecular recognition site; other site 226900001599 dimerization interface [polypeptide binding]; other site 226900001600 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 226900001601 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226900001602 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900001603 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226900001604 putative NAD(P) binding site [chemical binding]; other site 226900001605 EamA-like transporter family; Region: EamA; cl01037 226900001606 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900001607 EamA-like transporter family; Region: EamA; cl01037 226900001608 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900001609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900001610 DNA-binding site [nucleotide binding]; DNA binding site 226900001611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900001612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001613 homodimer interface [polypeptide binding]; other site 226900001614 catalytic residue [active] 226900001615 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 226900001616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001617 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900001618 Coenzyme A binding pocket [chemical binding]; other site 226900001619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900001620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001621 dimer interface [polypeptide binding]; other site 226900001622 phosphorylation site [posttranslational modification] 226900001623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001624 ATP binding site [chemical binding]; other site 226900001625 Mg2+ binding site [ion binding]; other site 226900001626 G-X-G motif; other site 226900001627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001629 active site 226900001630 phosphorylation site [posttranslational modification] 226900001631 intermolecular recognition site; other site 226900001632 dimerization interface [polypeptide binding]; other site 226900001633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001634 DNA binding site [nucleotide binding] 226900001635 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900001636 Arrestin_N terminal like; Region: LDB19; pfam13002 226900001637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001638 Coenzyme A binding pocket [chemical binding]; other site 226900001639 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 226900001640 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 226900001641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900001642 catalytic loop [active] 226900001643 iron binding site [ion binding]; other site 226900001644 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 226900001645 4Fe-4S binding domain; Region: Fer4; cl02805 226900001646 4Fe-4S binding domain; Region: Fer4; cl02805 226900001647 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 226900001648 [4Fe-4S] binding site [ion binding]; other site 226900001649 molybdopterin cofactor binding site; other site 226900001650 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 226900001651 molybdopterin cofactor binding site; other site 226900001652 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 226900001653 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 226900001654 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 226900001655 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 226900001656 putative active site [active] 226900001657 catalytic site [active] 226900001658 putative metal binding site [ion binding]; other site 226900001659 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 226900001660 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 226900001661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001662 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900001663 Amino acid permease; Region: AA_permease; cl00524 226900001664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900001665 dimerization interface [polypeptide binding]; other site 226900001666 putative DNA binding site [nucleotide binding]; other site 226900001667 putative Zn2+ binding site [ion binding]; other site 226900001668 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900001669 metal-binding site [ion binding] 226900001670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226900001671 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 226900001672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001673 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900001674 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 226900001675 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 226900001676 active site 226900001677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900001678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001679 non-specific DNA binding site [nucleotide binding]; other site 226900001680 salt bridge; other site 226900001681 sequence-specific DNA binding site [nucleotide binding]; other site 226900001682 Transposase IS200 like; Region: Y1_Tnp; cl00848 226900001683 Probable transposase; Region: OrfB_IS605; pfam01385 226900001684 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900001685 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900001686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900001687 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900001688 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900001689 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 226900001690 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900001691 active site 226900001692 Zn binding site [ion binding]; other site 226900001693 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900001694 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226900001695 VanW like protein; Region: VanW; pfam04294 226900001696 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900001697 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900001698 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900001699 Nucleoside recognition; Region: Gate; cl00486 226900001700 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900001701 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 226900001702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900001703 putative metal binding site [ion binding]; other site 226900001704 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900001705 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900001706 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900001707 Transporter associated domain; Region: CorC_HlyC; cl08393 226900001708 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 226900001709 Aspartase; Region: Aspartase; cd01357 226900001710 active sites [active] 226900001711 tetramer interface [polypeptide binding]; other site 226900001712 glycolate transporter; Provisional; Region: PRK09695 226900001713 L-lactate permease; Region: Lactate_perm; cl00701 226900001714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900001715 putative DNA binding site [nucleotide binding]; other site 226900001716 putative Zn2+ binding site [ion binding]; other site 226900001717 Small acid-soluble spore protein H family; Region: SspH; cl06949 226900001718 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226900001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001720 putative substrate translocation pore; other site 226900001721 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900001722 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900001723 siderophore binding site; other site 226900001724 similar to Iron(III) dicitrate transport system permease fecC 226900001725 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 226900001726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001727 ABC-ATPase subunit interface; other site 226900001728 dimer interface [polypeptide binding]; other site 226900001729 putative PBP binding regions; other site 226900001730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900001731 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900001732 Walker A/P-loop; other site 226900001733 ATP binding site [chemical binding]; other site 226900001734 Q-loop/lid; other site 226900001735 ABC transporter signature motif; other site 226900001736 Walker B; other site 226900001737 D-loop; other site 226900001738 H-loop/switch region; other site 226900001739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001740 S-adenosylmethionine binding site [chemical binding]; other site 226900001741 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 226900001742 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226900001743 substrate-cofactor binding pocket; other site 226900001744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001745 catalytic residue [active] 226900001746 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900001747 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 226900001748 NAD binding site [chemical binding]; other site 226900001749 homodimer interface [polypeptide binding]; other site 226900001750 active site 226900001751 putative substrate binding site [chemical binding]; other site 226900001752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900001753 nudix motif; other site 226900001754 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 226900001755 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 226900001756 metal ion-dependent adhesion site (MIDAS); other site 226900001757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001758 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 226900001759 Walker A motif; other site 226900001760 ATP binding site [chemical binding]; other site 226900001761 Walker B motif; other site 226900001762 arginine finger; other site 226900001763 cardiolipin synthetase; Reviewed; Region: PRK12452 226900001764 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900001765 putative active site [active] 226900001766 catalytic site [active] 226900001767 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900001768 putative active site [active] 226900001769 catalytic site [active] 226900001770 PAS domain S-box; Region: sensory_box; TIGR00229 226900001771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900001772 putative active site [active] 226900001773 heme pocket [chemical binding]; other site 226900001774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900001775 metal binding site [ion binding]; metal-binding site 226900001776 active site 226900001777 I-site; other site 226900001778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900001779 Amino acid permease; Region: AA_permease; cl00524 226900001780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900001781 DNA-binding site [nucleotide binding]; DNA binding site 226900001782 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 226900001783 UTRA domain; Region: UTRA; cl01230 226900001784 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 226900001785 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001786 active site turn [active] 226900001787 phosphorylation site [posttranslational modification] 226900001788 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900001789 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900001790 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900001791 Ca binding site [ion binding]; other site 226900001792 active site 226900001793 catalytic site [active] 226900001794 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900001795 Amino acid permease; Region: AA_permease; cl00524 226900001796 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900001797 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900001798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900001799 active site 226900001800 ATP binding site [chemical binding]; other site 226900001801 substrate binding site [chemical binding]; other site 226900001802 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900001803 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900001804 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 226900001805 Walker A/P-loop; other site 226900001806 ATP binding site [chemical binding]; other site 226900001807 Q-loop/lid; other site 226900001808 ABC transporter signature motif; other site 226900001809 Walker B; other site 226900001810 D-loop; other site 226900001811 H-loop/switch region; other site 226900001812 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 226900001813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900001814 substrate binding pocket [chemical binding]; other site 226900001815 membrane-bound complex binding site; other site 226900001816 hinge residues; other site 226900001817 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 226900001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001819 dimer interface [polypeptide binding]; other site 226900001820 conserved gate region; other site 226900001821 putative PBP binding loops; other site 226900001822 ABC-ATPase subunit interface; other site 226900001823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001824 dimer interface [polypeptide binding]; other site 226900001825 conserved gate region; other site 226900001826 putative PBP binding loops; other site 226900001827 ABC-ATPase subunit interface; other site 226900001828 Amino acid permease; Region: AA_permease; cl00524 226900001829 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900001830 OsmC-like protein; Region: OsmC; cl00767 226900001831 similar to Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical); EC_number 3.6.1.17 226900001832 RNA polymerase sigma factor; Provisional; Region: PRK12542 226900001833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900001834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900001835 DNA binding residues [nucleotide binding] 226900001836 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 226900001837 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900001838 Helix-turn-helix domains; Region: HTH; cl00088 226900001839 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 226900001840 folate binding site [chemical binding]; other site 226900001841 NADP+ binding site [chemical binding]; other site 226900001842 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 226900001843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001844 dimerization interface [polypeptide binding]; other site 226900001845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001846 dimer interface [polypeptide binding]; other site 226900001847 phosphorylation site [posttranslational modification] 226900001848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001849 ATP binding site [chemical binding]; other site 226900001850 Mg2+ binding site [ion binding]; other site 226900001851 G-X-G motif; other site 226900001852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001854 active site 226900001855 phosphorylation site [posttranslational modification] 226900001856 intermolecular recognition site; other site 226900001857 dimerization interface [polypeptide binding]; other site 226900001858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001859 DNA binding site [nucleotide binding] 226900001860 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 226900001861 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226900001862 Permease family; Region: Xan_ur_permease; cl00967 226900001863 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226900001864 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226900001865 Ligand Binding Site [chemical binding]; other site 226900001866 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 226900001867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001868 putative substrate translocation pore; other site 226900001869 Helix-turn-helix domains; Region: HTH; cl00088 226900001870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900001871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001872 putative substrate translocation pore; other site 226900001873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900001874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900001875 DNA binding site [nucleotide binding] 226900001876 domain linker motif; other site 226900001877 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 226900001878 dimerization interface [polypeptide binding]; other site 226900001879 ligand binding site [chemical binding]; other site 226900001880 sodium binding site [ion binding]; other site 226900001881 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 226900001882 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226900001883 substrate binding site [chemical binding]; other site 226900001884 dimer interface [polypeptide binding]; other site 226900001885 ATP binding site [chemical binding]; other site 226900001886 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 226900001887 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 226900001888 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 226900001889 Walker A/P-loop; other site 226900001890 ATP binding site [chemical binding]; other site 226900001891 Q-loop/lid; other site 226900001892 ABC transporter signature motif; other site 226900001893 Walker B; other site 226900001894 D-loop; other site 226900001895 H-loop/switch region; other site 226900001896 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 226900001897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900001898 TM-ABC transporter signature motif; other site 226900001899 similar to D-ribose-binding protein 226900001900 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226900001901 active site 226900001902 intersubunit interactions; other site 226900001903 catalytic residue [active] 226900001904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900001905 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 226900001906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900001908 putative substrate translocation pore; other site 226900001909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900001910 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 226900001911 putative NAD(P) binding site [chemical binding]; other site 226900001912 catalytic Zn binding site [ion binding]; other site 226900001913 Ion channel; Region: Ion_trans_2; cl11596 226900001914 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 226900001915 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 226900001916 putative catalytic site [active] 226900001917 metal binding site A [ion binding]; metal-binding site 226900001918 phosphate binding site [ion binding]; other site 226900001919 metal binding site C [ion binding]; metal-binding site 226900001920 metal binding site B [ion binding]; metal-binding site 226900001921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 226900001922 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 226900001923 dimer interface [polypeptide binding]; other site 226900001924 active site 226900001925 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900001926 substrate binding site [chemical binding]; other site 226900001927 catalytic residue [active] 226900001928 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 226900001929 FAD binding domain; Region: FAD_binding_4; pfam01565 226900001930 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 226900001931 VanZ like family; Region: VanZ; cl01971 226900001932 RDD family; Region: RDD; cl00746 226900001933 Bacitracin resistance protein BacA; Region: BacA; cl00858 226900001934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001935 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900001936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 226900001937 3D domain; Region: 3D; cl01439 226900001938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001939 non-specific DNA binding site [nucleotide binding]; other site 226900001940 salt bridge; other site 226900001941 sequence-specific DNA binding site [nucleotide binding]; other site 226900001942 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 226900001943 active site 226900001944 catalytic site [active] 226900001945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 226900001946 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226900001947 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900001948 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 226900001949 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 226900001950 Amino acid permease; Region: AA_permease; cl00524 226900001951 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900001952 Permease family; Region: Xan_ur_permease; cl00967 226900001953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001954 non-specific DNA binding site [nucleotide binding]; other site 226900001955 salt bridge; other site 226900001956 sequence-specific DNA binding site [nucleotide binding]; other site 226900001957 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900001958 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 226900001959 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 226900001960 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900001961 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900001962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001963 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900001964 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 226900001965 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 226900001966 Subunit I/III interface [polypeptide binding]; other site 226900001967 Subunit III/IV interface [polypeptide binding]; other site 226900001968 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 226900001969 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 226900001970 D-pathway; other site 226900001971 Putative ubiquinol binding site [chemical binding]; other site 226900001972 Low-spin heme (heme b) binding site [chemical binding]; other site 226900001973 Putative water exit pathway; other site 226900001974 Binuclear center (heme o3/CuB) [ion binding]; other site 226900001975 K-pathway; other site 226900001976 Putative proton exit pathway; other site 226900001977 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 226900001978 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 226900001979 Amino acid permease; Region: AA_permease; cl00524 226900001980 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900001981 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 226900001982 putative active site [active] 226900001983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900001984 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 226900001985 metal binding site [ion binding]; metal-binding site 226900001986 dimer interface [polypeptide binding]; other site 226900001987 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 226900001988 Sodium:solute symporter family; Region: SSF; cl00456 226900001989 similar to Spore germination protein KA 226900001990 Amino acid permease; Region: AA_permease; cl00524 226900001991 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900001992 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 226900001993 Nucleoside recognition; Region: Gate; cl00486 226900001994 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 226900001995 Nucleoside recognition; Region: Gate; cl00486 226900001996 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 226900001997 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 226900001998 G1 box; other site 226900001999 GTP/Mg2+ binding site [chemical binding]; other site 226900002000 Switch I region; other site 226900002001 G2 box; other site 226900002002 G3 box; other site 226900002003 Switch II region; other site 226900002004 G4 box; other site 226900002005 G5 box; other site 226900002006 FeoA domain; Region: FeoA; cl00838 226900002007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900002008 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 226900002009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002010 dimer interface [polypeptide binding]; other site 226900002011 conserved gate region; other site 226900002012 putative PBP binding loops; other site 226900002013 ABC-ATPase subunit interface; other site 226900002014 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226900002015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002016 dimer interface [polypeptide binding]; other site 226900002017 conserved gate region; other site 226900002018 putative PBP binding loops; other site 226900002019 ABC-ATPase subunit interface; other site 226900002020 Predicted kinase [General function prediction only]; Region: COG0645 226900002021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002022 active site 226900002023 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226900002024 Protein export membrane protein; Region: SecD_SecF; cl14618 226900002025 FOG: CBS domain [General function prediction only]; Region: COG0517 226900002026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 226900002027 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 226900002028 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 226900002029 Bacterial SH3 domain; Region: SH3_3; cl02551 226900002030 Bacterial SH3 domain; Region: SH3_3; cl02551 226900002031 Bacterial SH3 domain; Region: SH3_3; cl02551 226900002032 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900002033 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 226900002034 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900002035 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 226900002036 Walker A/P-loop; other site 226900002037 ATP binding site [chemical binding]; other site 226900002038 Q-loop/lid; other site 226900002039 ABC transporter signature motif; other site 226900002040 Walker B; other site 226900002041 D-loop; other site 226900002042 H-loop/switch region; other site 226900002043 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900002045 NMT1/THI5 like; Region: NMT1; pfam09084 226900002046 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900002047 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226900002048 thiamine phosphate binding site [chemical binding]; other site 226900002049 active site 226900002050 pyrophosphate binding site [ion binding]; other site 226900002051 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900002052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900002053 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 226900002054 thiS-thiF/thiG interaction site; other site 226900002055 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 226900002056 ThiS interaction site; other site 226900002057 putative active site [active] 226900002058 tetramer interface [polypeptide binding]; other site 226900002059 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 226900002060 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900002061 ATP binding site [chemical binding]; other site 226900002062 substrate interface [chemical binding]; other site 226900002063 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226900002064 dimer interface [polypeptide binding]; other site 226900002065 substrate binding site [chemical binding]; other site 226900002066 ATP binding site [chemical binding]; other site 226900002067 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 226900002068 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 226900002069 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900002070 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900002071 K+-transporting ATPase, c chain; Region: KdpC; cl00944 226900002072 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 226900002073 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 226900002074 Ligand Binding Site [chemical binding]; other site 226900002075 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226900002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002077 putative substrate translocation pore; other site 226900002078 Helix-turn-helix domains; Region: HTH; cl00088 226900002079 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 226900002080 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 226900002081 active site 226900002082 nucleophile elbow; other site 226900002083 FtsX-like permease family; Region: FtsX; pfam02687 226900002084 FtsX-like permease family; Region: FtsX; pfam02687 226900002085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900002086 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900002087 Walker A/P-loop; other site 226900002088 ATP binding site [chemical binding]; other site 226900002089 Q-loop/lid; other site 226900002090 ABC transporter signature motif; other site 226900002091 Walker B; other site 226900002092 D-loop; other site 226900002093 H-loop/switch region; other site 226900002094 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 226900002095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900002096 TM-ABC transporter signature motif; other site 226900002097 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 226900002098 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 226900002099 Walker A/P-loop; other site 226900002100 ATP binding site [chemical binding]; other site 226900002101 Q-loop/lid; other site 226900002102 ABC transporter signature motif; other site 226900002103 Walker B; other site 226900002104 D-loop; other site 226900002105 H-loop/switch region; other site 226900002106 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 226900002107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900002108 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 226900002109 putative ligand binding site [chemical binding]; other site 226900002110 Permease family; Region: Xan_ur_permease; cl00967 226900002111 short chain dehydrogenase; Provisional; Region: PRK06701 226900002112 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 226900002113 NAD binding site [chemical binding]; other site 226900002114 metal binding site [ion binding]; metal-binding site 226900002115 active site 226900002116 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 226900002117 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 226900002118 putative substrate binding site [chemical binding]; other site 226900002119 putative ATP binding site [chemical binding]; other site 226900002120 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 226900002121 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226900002122 substrate binding [chemical binding]; other site 226900002123 active site 226900002124 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226900002125 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 226900002126 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900002127 active site turn [active] 226900002128 phosphorylation site [posttranslational modification] 226900002129 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900002130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900002131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900002132 DNA binding site [nucleotide binding] 226900002133 domain linker motif; other site 226900002134 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 226900002135 dimerization interface [polypeptide binding]; other site 226900002136 ligand binding site [chemical binding]; other site 226900002137 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900002138 catalytic residues [active] 226900002139 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 226900002140 YhdB-like protein; Region: YhdB; pfam14148 226900002141 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 226900002142 Amino acid permease; Region: AA_permease; cl00524 226900002143 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900002144 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900002145 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 226900002146 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 226900002147 putative FMN binding site [chemical binding]; other site 226900002148 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 226900002149 SpoVR like protein; Region: SpoVR; pfam04293 226900002150 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 226900002151 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 226900002152 Protein of unknown function, DUF2606; Region: DUF2606; pfam10794 226900002153 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226900002154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900002155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 226900002156 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 226900002157 active site residue [active] 226900002158 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 226900002159 putative homotetramer interface [polypeptide binding]; other site 226900002160 putative homodimer interface [polypeptide binding]; other site 226900002161 putative metal binding site [ion binding]; other site 226900002162 putative homodimer-homodimer interface [polypeptide binding]; other site 226900002163 putative allosteric switch controlling residues; other site 226900002164 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 226900002165 CPxP motif; other site 226900002166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002167 active site residue [active] 226900002168 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 226900002169 active site residue [active] 226900002170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900002171 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 226900002172 CPxP motif; other site 226900002173 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002174 active site residue [active] 226900002175 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002176 active site residue [active] 226900002177 DsrE/DsrF-like family; Region: DrsE; cl00672 226900002178 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900002179 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900002180 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 226900002181 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 226900002182 NADP binding site [chemical binding]; other site 226900002183 dimer interface [polypeptide binding]; other site 226900002184 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 226900002185 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 226900002186 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 226900002187 PhoU domain; Region: PhoU; pfam01895 226900002188 PhoU domain; Region: PhoU; pfam01895 226900002189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002191 putative substrate translocation pore; other site 226900002192 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 226900002193 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 226900002194 Helix-turn-helix domains; Region: HTH; cl00088 226900002195 Helix-turn-helix domains; Region: HTH; cl00088 226900002196 PRD domain; Region: PRD; cl15445 226900002197 PRD domain; Region: PRD; cl15445 226900002198 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226900002199 P-loop; other site 226900002200 active site 226900002201 phosphorylation site [posttranslational modification] 226900002202 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226900002203 active site 226900002204 phosphorylation site [posttranslational modification] 226900002205 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900002206 active site 226900002207 methionine cluster; other site 226900002208 phosphorylation site [posttranslational modification] 226900002209 metal binding site [ion binding]; metal-binding site 226900002210 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900002211 active site 226900002212 P-loop; other site 226900002213 phosphorylation site [posttranslational modification] 226900002214 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900002215 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 226900002216 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 226900002217 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 226900002218 Bacterial SH3 domain; Region: SH3_3; cl02551 226900002219 Bacterial SH3 domain; Region: SH3_3; cl02551 226900002220 3D domain; Region: 3D; cl01439 226900002221 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900002222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226900002223 FtsX-like permease family; Region: FtsX; pfam02687 226900002224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900002225 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900002226 Walker A/P-loop; other site 226900002227 ATP binding site [chemical binding]; other site 226900002228 Q-loop/lid; other site 226900002229 ABC transporter signature motif; other site 226900002230 Walker B; other site 226900002231 D-loop; other site 226900002232 H-loop/switch region; other site 226900002233 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226900002234 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 226900002235 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 226900002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900002237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002238 dimer interface [polypeptide binding]; other site 226900002239 conserved gate region; other site 226900002240 ABC-ATPase subunit interface; other site 226900002241 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900002242 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 226900002243 dimanganese center [ion binding]; other site 226900002244 CotJB protein; Region: CotJB; pfam12652 226900002245 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 226900002246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900002247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900002248 active site 226900002249 metal binding site [ion binding]; metal-binding site 226900002250 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002251 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002252 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 226900002253 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 226900002254 putative DNA binding site [nucleotide binding]; other site 226900002255 putative homodimer interface [polypeptide binding]; other site 226900002256 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 226900002257 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900002258 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900002259 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 226900002260 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 226900002261 similar to phosphohydrolases, Icc family 226900002262 similar to Amino acid permease 226900002263 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900002264 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 226900002265 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226900002266 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226900002267 putative active site [active] 226900002268 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 226900002269 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 226900002270 putative active site [active] 226900002271 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 226900002272 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900002273 active site turn [active] 226900002274 phosphorylation site [posttranslational modification] 226900002275 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900002276 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 226900002277 DoxX; Region: DoxX; cl00976 226900002278 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002279 hypothetical protein; Provisional; Region: PRK06770 226900002280 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900002281 EamA-like transporter family; Region: EamA; cl01037 226900002282 EamA-like transporter family; Region: EamA; cl01037 226900002283 Helix-turn-helix domains; Region: HTH; cl00088 226900002284 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 226900002285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900002286 Coenzyme A binding pocket [chemical binding]; other site 226900002287 classical (c) SDRs; Region: SDR_c; cd05233 226900002288 NAD(P) binding site [chemical binding]; other site 226900002289 active site 226900002290 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900002291 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 226900002292 DNA binding residues [nucleotide binding] 226900002293 putative dimer interface [polypeptide binding]; other site 226900002294 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226900002295 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226900002296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002297 Helix-turn-helix domains; Region: HTH; cl00088 226900002298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002301 Helix-turn-helix domains; Region: HTH; cl00088 226900002302 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002303 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900002304 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 226900002305 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 226900002306 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 226900002307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002308 putative substrate translocation pore; other site 226900002309 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 226900002310 proposed catalytic triad [active] 226900002311 conserved cys residue [active] 226900002312 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900002313 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 226900002314 tetramer interface [polypeptide binding]; other site 226900002315 heme binding pocket [chemical binding]; other site 226900002316 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 226900002317 domain interactions; other site 226900002318 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 226900002319 Amino acid permease; Region: AA_permease; cl00524 226900002320 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900002321 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900002322 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 226900002323 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 226900002324 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900002325 tetrameric interface [polypeptide binding]; other site 226900002326 activator binding site; other site 226900002327 NADP binding site [chemical binding]; other site 226900002328 substrate binding site [chemical binding]; other site 226900002329 catalytic residues [active] 226900002330 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900002331 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 226900002332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002333 Walker A/P-loop; other site 226900002334 ATP binding site [chemical binding]; other site 226900002335 Q-loop/lid; other site 226900002336 ABC transporter signature motif; other site 226900002337 Walker B; other site 226900002338 D-loop; other site 226900002339 H-loop/switch region; other site 226900002340 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900002341 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 226900002342 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 226900002343 Walker A/P-loop; other site 226900002344 ATP binding site [chemical binding]; other site 226900002345 Q-loop/lid; other site 226900002346 ABC transporter signature motif; other site 226900002347 Walker B; other site 226900002348 D-loop; other site 226900002349 H-loop/switch region; other site 226900002350 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226900002351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900002352 substrate binding pocket [chemical binding]; other site 226900002353 membrane-bound complex binding site; other site 226900002354 hinge residues; other site 226900002355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002356 dimer interface [polypeptide binding]; other site 226900002357 conserved gate region; other site 226900002358 putative PBP binding loops; other site 226900002359 ABC-ATPase subunit interface; other site 226900002360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900002361 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 226900002362 Walker A/P-loop; other site 226900002363 ATP binding site [chemical binding]; other site 226900002364 Q-loop/lid; other site 226900002365 ABC transporter signature motif; other site 226900002366 Walker B; other site 226900002367 D-loop; other site 226900002368 H-loop/switch region; other site 226900002369 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900002370 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900002371 ATP-grasp domain; Region: ATP-grasp_4; cl03087 226900002372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 226900002373 Protein of unknown function (DUF964); Region: DUF964; cl01483 226900002374 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900002375 Histidine kinase; Region: HisKA_3; pfam07730 226900002376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226900002377 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900002378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002379 active site 226900002380 phosphorylation site [posttranslational modification] 226900002381 intermolecular recognition site; other site 226900002382 dimerization interface [polypeptide binding]; other site 226900002383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900002384 DNA binding residues [nucleotide binding] 226900002385 dimerization interface [polypeptide binding]; other site 226900002386 acetolactate synthase; Reviewed; Region: PRK08617 226900002387 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226900002388 PYR/PP interface [polypeptide binding]; other site 226900002389 dimer interface [polypeptide binding]; other site 226900002390 TPP binding site [chemical binding]; other site 226900002391 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 226900002392 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 226900002393 TPP-binding site [chemical binding]; other site 226900002394 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 226900002395 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 226900002396 active site 226900002397 DNA binding site [nucleotide binding] 226900002398 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900002399 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900002400 active site 226900002401 motif I; other site 226900002402 motif II; other site 226900002403 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900002404 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002405 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002406 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002407 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002408 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002409 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002410 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002411 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002412 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002413 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900002414 amidase catalytic site [active] 226900002415 Zn binding residues [ion binding]; other site 226900002416 substrate binding site [chemical binding]; other site 226900002417 S-layer homology domain; Region: SLH; pfam00395 226900002418 S-layer homology domain; Region: SLH; pfam00395 226900002419 S-layer homology domain; Region: SLH; pfam00395 226900002420 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 226900002421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900002422 FeS/SAM binding site; other site 226900002423 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 226900002424 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900002425 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226900002426 Permease family; Region: Xan_ur_permease; cl00967 226900002427 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226900002428 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900002429 MatE; Region: MatE; cl10513 226900002430 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 226900002431 S-layer homology domain; Region: SLH; pfam00395 226900002432 S-layer homology domain; Region: SLH; pfam00395 226900002433 S-layer homology domain; Region: SLH; pfam00395 226900002434 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 226900002435 O-Antigen ligase; Region: Wzy_C; cl04850 226900002436 enoyl-CoA hydratase; Provisional; Region: PRK07659 226900002437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900002438 substrate binding site [chemical binding]; other site 226900002439 oxyanion hole (OAH) forming residues; other site 226900002440 trimer interface [polypeptide binding]; other site 226900002441 Uncharacterized conserved protein [Function unknown]; Region: COG4997 226900002442 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 226900002443 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 226900002444 putative oligomer interface [polypeptide binding]; other site 226900002445 putative active site [active] 226900002446 metal binding site [ion binding]; metal-binding site 226900002447 S-layer homology domain; Region: SLH; pfam00395 226900002448 S-layer homology domain; Region: SLH; pfam00395 226900002449 S-layer homology domain; Region: SLH; pfam00395 226900002450 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900002451 active site 226900002452 metal binding site [ion binding]; metal-binding site 226900002453 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 226900002454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900002455 S-adenosylmethionine binding site [chemical binding]; other site 226900002456 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 226900002457 proline racemase; Provisional; Region: PRK13969 226900002458 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 226900002459 ornithine cyclodeaminase; Validated; Region: PRK08618 226900002460 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 226900002461 NAD(P) binding site [chemical binding]; other site 226900002462 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 226900002463 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 226900002464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900002465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002466 dimer interface [polypeptide binding]; other site 226900002467 conserved gate region; other site 226900002468 putative PBP binding loops; other site 226900002469 ABC-ATPase subunit interface; other site 226900002470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900002471 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900002472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002473 dimer interface [polypeptide binding]; other site 226900002474 conserved gate region; other site 226900002475 putative PBP binding loops; other site 226900002476 ABC-ATPase subunit interface; other site 226900002477 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900002478 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900002479 Walker A/P-loop; other site 226900002480 ATP binding site [chemical binding]; other site 226900002481 Q-loop/lid; other site 226900002482 ABC transporter signature motif; other site 226900002483 Walker B; other site 226900002484 D-loop; other site 226900002485 H-loop/switch region; other site 226900002486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900002487 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 226900002488 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900002489 Walker A/P-loop; other site 226900002490 ATP binding site [chemical binding]; other site 226900002491 Q-loop/lid; other site 226900002492 ABC transporter signature motif; other site 226900002493 Walker B; other site 226900002494 D-loop; other site 226900002495 H-loop/switch region; other site 226900002496 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900002497 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 226900002498 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 226900002499 catalytic residues [active] 226900002500 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900002501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900002502 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002503 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 226900002505 Proteins of 100 residues with WXG; Region: WXG100; cl02005 226900002506 Bacillus transposase protein; Region: Transposase_30; pfam04740 226900002507 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 226900002508 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900002509 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 226900002510 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 226900002511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002512 putative substrate translocation pore; other site 226900002513 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 226900002514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900002515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002516 ATP binding site [chemical binding]; other site 226900002517 Mg2+ binding site [ion binding]; other site 226900002518 G-X-G motif; other site 226900002519 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226900002520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002521 active site 226900002522 phosphorylation site [posttranslational modification] 226900002523 intermolecular recognition site; other site 226900002524 dimerization interface [polypeptide binding]; other site 226900002525 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900002526 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 226900002527 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 226900002528 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 226900002529 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 226900002530 cofactor binding site; other site 226900002531 DNA binding site [nucleotide binding] 226900002532 substrate interaction site [chemical binding]; other site 226900002533 Helix-turn-helix domains; Region: HTH; cl00088 226900002534 Protein of unknown function DUF262; Region: DUF262; cl14890 226900002535 Domain of unknown function (DUF1994); Region: DUF1994; cl09179 226900002536 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900002537 Phage integrase family; Region: Phage_integrase; pfam00589 226900002538 Int/Topo IB signature motif; other site 226900002539 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226900002540 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 226900002541 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 226900002542 Tic20-like protein; Region: Tic20; pfam09685 226900002543 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900002544 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900002545 DNA binding residues [nucleotide binding] 226900002546 dimer interface [polypeptide binding]; other site 226900002547 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226900002548 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900002549 replicative DNA helicase; Provisional; Region: PRK06749 226900002550 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 226900002551 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 226900002552 Walker A motif; other site 226900002553 ATP binding site [chemical binding]; other site 226900002554 Walker B motif; other site 226900002555 DNA binding loops [nucleotide binding] 226900002556 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 226900002557 Helix-turn-helix domains; Region: HTH; cl00088 226900002558 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900002559 C-terminal domain interface [polypeptide binding]; other site 226900002560 sugar binding site [chemical binding]; other site 226900002561 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900002562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900002563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002564 Helix-turn-helix domains; Region: HTH; cl00088 226900002565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002566 putative substrate translocation pore; other site 226900002567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002568 hypothetical protein; Provisional; Region: PRK06770 226900002569 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900002570 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900002571 Excalibur calcium-binding domain; Region: Excalibur; cl05460 226900002572 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 226900002573 active site 226900002574 catalytic site [active] 226900002575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900002576 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900002577 isoform II; Region: PAF-AH_p_II; pfam03403 226900002578 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226900002579 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 226900002580 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 226900002581 CGNR zinc finger; Region: zf-CGNR; pfam11706 226900002582 HPP family; Region: HPP; pfam04982 226900002583 YmzC-like protein; Region: YmzC; pfam14157 226900002584 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900002585 Helix-turn-helix domains; Region: HTH; cl00088 226900002586 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900002587 ATP synthase I chain; Region: ATP_synt_I; cl09170 226900002588 VanZ like family; Region: VanZ; cl01971 226900002589 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 226900002590 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 226900002591 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 226900002592 Helix-turn-helix domains; Region: HTH; cl00088 226900002593 dihydroxyacetone kinase; Provisional; Region: PRK14479 226900002594 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 226900002595 DAK2 domain; Region: Dak2; cl03685 226900002596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900002597 TPR motif; other site 226900002598 binding surface 226900002599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002600 non-specific DNA binding site [nucleotide binding]; other site 226900002601 salt bridge; other site 226900002602 sequence-specific DNA binding site [nucleotide binding]; other site 226900002603 S-layer homology domain; Region: SLH; pfam00395 226900002604 S-layer homology domain; Region: SLH; pfam00395 226900002605 S-layer homology domain; Region: SLH; pfam00395 226900002606 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 226900002607 Helix-turn-helix domains; Region: HTH; cl00088 226900002608 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 226900002609 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 226900002610 Heat induced stress protein YflT; Region: YflT; pfam11181 226900002611 CsbD-like; Region: CsbD; cl01888 226900002612 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 226900002613 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 226900002614 anti sigma factor interaction site; other site 226900002615 regulatory phosphorylation site [posttranslational modification]; other site 226900002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002617 ATP binding site [chemical binding]; other site 226900002618 Mg2+ binding site [ion binding]; other site 226900002619 G-X-G motif; other site 226900002620 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 226900002621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900002622 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900002623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900002624 DNA binding residues [nucleotide binding] 226900002625 Ferritin-like domain; Region: Ferritin; pfam00210 226900002626 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 226900002627 dinuclear metal binding motif [ion binding]; other site 226900002628 Response regulator receiver domain; Region: Response_reg; pfam00072 226900002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002630 active site 226900002631 phosphorylation site [posttranslational modification] 226900002632 intermolecular recognition site; other site 226900002633 dimerization interface [polypeptide binding]; other site 226900002634 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 226900002635 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900002636 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 226900002637 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 226900002638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900002639 CHASE3 domain; Region: CHASE3; cl05000 226900002640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900002641 dimer interface [polypeptide binding]; other site 226900002642 phosphorylation site [posttranslational modification] 226900002643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002644 ATP binding site [chemical binding]; other site 226900002645 Mg2+ binding site [ion binding]; other site 226900002646 G-X-G motif; other site 226900002647 Response regulator receiver domain; Region: Response_reg; pfam00072 226900002648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002649 active site 226900002650 phosphorylation site [posttranslational modification] 226900002651 intermolecular recognition site; other site 226900002652 dimerization interface [polypeptide binding]; other site 226900002653 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 226900002654 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 226900002655 Domain of unknown function (DUF74); Region: DUF74; cl00426 226900002656 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900002657 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 226900002658 NADP binding site [chemical binding]; other site 226900002659 dimer interface [polypeptide binding]; other site 226900002660 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 226900002661 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 226900002662 active site 226900002663 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 226900002664 YhzD-like protein; Region: YhzD; pfam14120 226900002665 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900002666 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900002667 active site 226900002668 metal binding site [ion binding]; metal-binding site 226900002669 DNA binding site [nucleotide binding] 226900002670 Uncharacterized conserved protein [Function unknown]; Region: COG4717 226900002671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002672 Q-loop/lid; other site 226900002673 ABC transporter signature motif; other site 226900002674 Walker B; other site 226900002675 D-loop; other site 226900002676 H-loop/switch region; other site 226900002677 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 226900002678 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 226900002679 generic binding surface II; other site 226900002680 generic binding surface I; other site 226900002681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900002682 Zn2+ binding site [ion binding]; other site 226900002683 Mg2+ binding site [ion binding]; other site 226900002684 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 226900002685 LysE type translocator; Region: LysE; cl00565 226900002686 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900002687 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900002688 Zn binding site [ion binding]; other site 226900002689 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900002690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900002691 Zn binding site [ion binding]; other site 226900002692 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900002693 Zn binding site [ion binding]; other site 226900002694 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900002695 Zn binding site [ion binding]; other site 226900002696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900002697 TPR motif; other site 226900002698 binding surface 226900002699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900002700 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 226900002701 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 226900002702 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002703 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002704 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 226900002705 Cupin domain; Region: Cupin_2; cl09118 226900002706 Cupin domain; Region: Cupin_2; cl09118 226900002707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002708 non-specific DNA binding site [nucleotide binding]; other site 226900002709 salt bridge; other site 226900002710 sequence-specific DNA binding site [nucleotide binding]; other site 226900002711 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 226900002712 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 226900002713 amphipathic channel; other site 226900002714 Asn-Pro-Ala signature motifs; other site 226900002715 glycerol kinase; Provisional; Region: glpK; PRK00047 226900002716 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 226900002717 N- and C-terminal domain interface [polypeptide binding]; other site 226900002718 active site 226900002719 MgATP binding site [chemical binding]; other site 226900002720 catalytic site [active] 226900002721 metal binding site [ion binding]; metal-binding site 226900002722 glycerol binding site [chemical binding]; other site 226900002723 homotetramer interface [polypeptide binding]; other site 226900002724 homodimer interface [polypeptide binding]; other site 226900002725 FBP binding site [chemical binding]; other site 226900002726 protein IIAGlc interface [polypeptide binding]; other site 226900002727 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 226900002728 Helix-turn-helix domains; Region: HTH; cl00088 226900002729 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 226900002730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002732 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 226900002733 PPIC-type PPIASE domain; Region: Rotamase; cl08278 226900002734 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 226900002735 transcriptional regulator Hpr; Provisional; Region: PRK13777 226900002736 Helix-turn-helix domains; Region: HTH; cl00088 226900002737 YtxH-like protein; Region: YtxH; cl02079 226900002738 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 226900002739 HIT family signature motif; other site 226900002740 catalytic residue [active] 226900002741 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900002742 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900002743 Walker A/P-loop; other site 226900002744 ATP binding site [chemical binding]; other site 226900002745 Q-loop/lid; other site 226900002746 ABC transporter signature motif; other site 226900002747 Walker B; other site 226900002748 D-loop; other site 226900002749 H-loop/switch region; other site 226900002750 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 226900002751 EcsC protein family; Region: EcsC; pfam12787 226900002752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002753 Helix-turn-helix domains; Region: HTH; cl00088 226900002754 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002755 Predicted membrane protein [Function unknown]; Region: COG3428 226900002756 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002757 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002758 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002759 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 226900002760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002761 Helix-turn-helix domains; Region: HTH; cl00088 226900002762 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002763 Collagen binding domain; Region: Collagen_bind; pfam05737 226900002764 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002765 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002766 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002767 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002768 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002769 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002770 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002771 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002772 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002773 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002774 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002775 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002776 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002777 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002778 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002779 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002780 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002781 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900002782 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 226900002783 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 226900002784 classical (c) SDRs; Region: SDR_c; cd05233 226900002785 NAD(P) binding site [chemical binding]; other site 226900002786 active site 226900002787 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900002788 EamA-like transporter family; Region: EamA; cl01037 226900002789 EamA-like transporter family; Region: EamA; cl01037 226900002790 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002791 Predicted membrane protein [Function unknown]; Region: COG3428 226900002792 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002793 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002794 Bacterial membrane flanked domain; Region: DUF304; cl01348 226900002795 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900002796 Transglycosylase; Region: Transgly; cl07896 226900002797 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900002798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900002799 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 226900002800 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 226900002801 substrate binding site [chemical binding]; other site 226900002802 active site 226900002803 ferrochelatase; Provisional; Region: PRK12435 226900002804 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 226900002805 C-terminal domain interface [polypeptide binding]; other site 226900002806 active site 226900002807 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 226900002808 active site 226900002809 N-terminal domain interface [polypeptide binding]; other site 226900002810 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 226900002811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900002812 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl01543 226900002813 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 226900002814 generic binding surface I; other site 226900002815 generic binding surface II; other site 226900002816 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 226900002817 putative active site [active] 226900002818 putative catalytic site [active] 226900002819 putative Mg binding site IVb [ion binding]; other site 226900002820 putative phosphate binding site [ion binding]; other site 226900002821 putative DNA binding site [nucleotide binding]; other site 226900002822 putative Mg binding site IVa [ion binding]; other site 226900002823 Helix-turn-helix domains; Region: HTH; cl00088 226900002824 Peptidase family M48; Region: Peptidase_M48; cl12018 226900002825 Helix-turn-helix domains; Region: HTH; cl00088 226900002826 Predicted membrane protein [Function unknown]; Region: COG1511 226900002827 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900002828 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 226900002829 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900002830 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900002831 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 226900002832 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900002834 Coenzyme A binding pocket [chemical binding]; other site 226900002835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900002836 DNA binding site [nucleotide binding] 226900002837 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 226900002838 domain linker motif; other site 226900002839 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900002840 putative dimerization interface [polypeptide binding]; other site 226900002841 putative ligand binding site [chemical binding]; other site 226900002842 YhfH-like protein; Region: YhfH; pfam14149 226900002843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900002844 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 226900002845 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 226900002846 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 226900002847 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900002848 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 226900002849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900002850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900002851 sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139 226900002852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002853 dimer interface [polypeptide binding]; other site 226900002854 conserved gate region; other site 226900002855 putative PBP binding loops; other site 226900002856 ABC-ATPase subunit interface; other site 226900002857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002858 dimer interface [polypeptide binding]; other site 226900002859 conserved gate region; other site 226900002860 putative PBP binding loops; other site 226900002861 ABC-ATPase subunit interface; other site 226900002862 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 226900002863 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 226900002864 Walker A/P-loop; other site 226900002865 ATP binding site [chemical binding]; other site 226900002866 Q-loop/lid; other site 226900002867 ABC transporter signature motif; other site 226900002868 Walker B; other site 226900002869 D-loop; other site 226900002870 H-loop/switch region; other site 226900002871 TOBE domain; Region: TOBE_2; cl01440 226900002872 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 226900002873 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 226900002874 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 226900002875 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900002876 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900002877 putative active site [active] 226900002878 putative metal binding site [ion binding]; other site 226900002879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900002880 hypothetical protein; Provisional; Region: PHA02725 226900002881 Putative zinc-finger; Region: zf-HC2; cl15806 226900002882 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 226900002883 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 226900002884 RNA polymerase sigma factor; Provisional; Region: PRK12541 226900002885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900002886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900002887 DNA binding residues [nucleotide binding] 226900002888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900002889 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900002890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900002891 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900002892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900002893 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900002894 active site 226900002895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900002896 dimer interface [polypeptide binding]; other site 226900002897 phosphorylation site [posttranslational modification] 226900002898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002899 ATP binding site [chemical binding]; other site 226900002900 Mg2+ binding site [ion binding]; other site 226900002901 G-X-G motif; other site 226900002902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900002903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002904 active site 226900002905 phosphorylation site [posttranslational modification] 226900002906 intermolecular recognition site; other site 226900002907 dimerization interface [polypeptide binding]; other site 226900002908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900002909 DNA binding site [nucleotide binding] 226900002910 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900002911 Peptidase family M48; Region: Peptidase_M48; cl12018 226900002912 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 226900002913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900002914 dimerization interface [polypeptide binding]; other site 226900002915 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900002916 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900002917 S-layer homology domain; Region: SLH; pfam00395 226900002918 S-layer homology domain; Region: SLH; pfam00395 226900002919 S-layer homology domain; Region: SLH; pfam00395 226900002920 S-layer homology domain; Region: SLH; pfam00395 226900002921 S-layer homology domain; Region: SLH; pfam00395 226900002922 S-layer homology domain; Region: SLH; pfam00395 226900002923 malate synthase A; Region: malate_syn_A; TIGR01344 226900002924 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 226900002925 active site 226900002926 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 226900002927 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 226900002928 tetramer interface [polypeptide binding]; other site 226900002929 active site 226900002930 Mg2+/Mn2+ binding site [ion binding]; other site 226900002931 Phosphotransferase enzyme family; Region: APH; pfam01636 226900002932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 226900002933 active site 226900002934 substrate binding site [chemical binding]; other site 226900002935 ATP binding site [chemical binding]; other site 226900002936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900002937 DNA-binding site [nucleotide binding]; DNA binding site 226900002938 RNA-binding motif; other site 226900002939 ComK protein; Region: ComK; cl11560 226900002940 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900002941 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900002942 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900002943 Catalytic site [active] 226900002944 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900002945 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 226900002946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002947 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 226900002948 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 226900002949 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 226900002950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900002952 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 226900002953 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 226900002954 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900002955 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 226900002956 Spore germination protein GerPC; Region: GerPC; pfam10737 226900002957 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 226900002958 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900002959 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900002960 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 226900002961 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 226900002962 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900002963 inhibitor-cofactor binding pocket; inhibition site 226900002964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900002965 catalytic residue [active] 226900002966 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 226900002967 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 226900002968 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226900002969 active site 226900002970 dimer interface [polypeptide binding]; other site 226900002971 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900002972 Ligand Binding Site [chemical binding]; other site 226900002973 Molecular Tunnel; other site 226900002974 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900002975 ferrochelatase; Provisional; Region: PRK12435 226900002976 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 226900002977 C-terminal domain interface [polypeptide binding]; other site 226900002978 active site 226900002979 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 226900002980 active site 226900002981 N-terminal domain interface [polypeptide binding]; other site 226900002982 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900002983 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 226900002984 tetramer interface [polypeptide binding]; other site 226900002985 heme binding pocket [chemical binding]; other site 226900002986 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 226900002987 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226900002988 active site 226900002989 catalytic site [active] 226900002990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002991 non-specific DNA binding site [nucleotide binding]; other site 226900002992 salt bridge; other site 226900002993 sequence-specific DNA binding site [nucleotide binding]; other site 226900002994 Protein of unknown function (DUF520); Region: DUF520; cl00723 226900002995 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 226900002996 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 226900002997 PPIC-type PPIASE domain; Region: Rotamase; cl08278 226900002998 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900002999 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900003000 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900003001 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 226900003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900003003 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900003004 active site 226900003005 motif I; other site 226900003006 motif II; other site 226900003007 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900003008 YjzC-like protein; Region: YjzC; pfam14168 226900003009 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 226900003010 Clp amino terminal domain; Region: Clp_N; pfam02861 226900003011 Clp amino terminal domain; Region: Clp_N; pfam02861 226900003012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900003013 Walker A motif; other site 226900003014 ATP binding site [chemical binding]; other site 226900003015 Walker B motif; other site 226900003016 arginine finger; other site 226900003017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900003018 Walker A motif; other site 226900003019 ATP binding site [chemical binding]; other site 226900003020 Walker B motif; other site 226900003021 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 226900003022 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 226900003023 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226900003024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900003025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003026 NAD(P) binding site [chemical binding]; other site 226900003027 active site 226900003028 ComZ; Region: ComZ; pfam10815 226900003029 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 226900003030 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226900003031 dimer interface [polypeptide binding]; other site 226900003032 active site 226900003033 CoA binding pocket [chemical binding]; other site 226900003034 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 226900003035 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 226900003036 dimer interface [polypeptide binding]; other site 226900003037 active site 226900003038 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 226900003039 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 226900003040 similar to Tryptophanyl-tRNA synthetase; EC_number 6.1.1.2 226900003041 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 226900003042 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900003043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900003044 peptide binding site [polypeptide binding]; other site 226900003045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900003046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003047 dimer interface [polypeptide binding]; other site 226900003048 conserved gate region; other site 226900003049 putative PBP binding loops; other site 226900003050 ABC-ATPase subunit interface; other site 226900003051 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900003052 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 226900003053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003054 dimer interface [polypeptide binding]; other site 226900003055 conserved gate region; other site 226900003056 putative PBP binding loops; other site 226900003057 ABC-ATPase subunit interface; other site 226900003058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900003059 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900003060 Walker A/P-loop; other site 226900003061 ATP binding site [chemical binding]; other site 226900003062 Q-loop/lid; other site 226900003063 ABC transporter signature motif; other site 226900003064 Walker B; other site 226900003065 D-loop; other site 226900003066 H-loop/switch region; other site 226900003067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900003068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226900003069 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 226900003070 Walker A/P-loop; other site 226900003071 ATP binding site [chemical binding]; other site 226900003072 Q-loop/lid; other site 226900003073 ABC transporter signature motif; other site 226900003074 Walker B; other site 226900003075 D-loop; other site 226900003076 H-loop/switch region; other site 226900003077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900003078 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226900003079 MatE; Region: MatE; cl10513 226900003080 MatE; Region: MatE; cl10513 226900003081 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900003082 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900003083 peptide binding site [polypeptide binding]; other site 226900003084 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 226900003085 ArsC family; Region: ArsC; pfam03960 226900003086 putative catalytic residues [active] 226900003087 thiol/disulfide switch; other site 226900003088 Integral membrane protein TerC family; Region: TerC; cl10468 226900003089 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 226900003090 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 226900003091 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900003092 putative active site [active] 226900003093 catalytic site [active] 226900003094 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900003095 putative active site [active] 226900003096 catalytic site [active] 226900003097 Competence protein CoiA-like family; Region: CoiA; cl11541 226900003098 oligoendopeptidase F; Region: pepF; TIGR00181 226900003099 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 226900003100 active site 226900003101 Zn binding site [ion binding]; other site 226900003102 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 226900003103 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 226900003104 catalytic residues [active] 226900003105 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 226900003106 apolar tunnel; other site 226900003107 heme binding site [chemical binding]; other site 226900003108 dimerization interface [polypeptide binding]; other site 226900003109 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 226900003110 putative active site [active] 226900003111 putative metal binding residues [ion binding]; other site 226900003112 signature motif; other site 226900003113 putative triphosphate binding site [ion binding]; other site 226900003114 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900003115 synthetase active site [active] 226900003116 NTP binding site [chemical binding]; other site 226900003117 metal binding site [ion binding]; metal-binding site 226900003118 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 226900003119 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226900003120 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 226900003121 active site 226900003122 similar to Cell surface protein 226900003123 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 226900003124 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 226900003125 active site 226900003126 metal binding site [ion binding]; metal-binding site 226900003127 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900003128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900003129 active site 226900003130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003131 S-adenosylmethionine binding site [chemical binding]; other site 226900003132 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 226900003133 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 226900003134 putative metal binding site; other site 226900003135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900003136 binding surface 226900003137 TPR motif; other site 226900003138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003139 S-adenosylmethionine binding site [chemical binding]; other site 226900003140 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 226900003141 catalytic residues [active] 226900003142 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 226900003143 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 226900003144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900003145 active site 226900003146 Cupin domain; Region: Cupin_2; cl09118 226900003147 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 226900003148 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 226900003149 NAD binding site [chemical binding]; other site 226900003150 substrate binding site [chemical binding]; other site 226900003151 homodimer interface [polypeptide binding]; other site 226900003152 active site 226900003153 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226900003154 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 226900003155 NADP binding site [chemical binding]; other site 226900003156 active site 226900003157 putative substrate binding site [chemical binding]; other site 226900003158 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 226900003159 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 226900003160 NAD binding site [chemical binding]; other site 226900003161 homotetramer interface [polypeptide binding]; other site 226900003162 homodimer interface [polypeptide binding]; other site 226900003163 substrate binding site [chemical binding]; other site 226900003164 active site 226900003165 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 226900003166 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 226900003167 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 226900003168 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 226900003169 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 226900003170 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 226900003171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900003174 Coenzyme A binding pocket [chemical binding]; other site 226900003175 hypothetical protein; Provisional; Region: PRK13679 226900003176 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 226900003177 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900003178 Putative esterase; Region: Esterase; pfam00756 226900003179 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900003180 EamA-like transporter family; Region: EamA; cl01037 226900003181 EamA-like transporter family; Region: EamA; cl01037 226900003182 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 226900003183 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226900003184 Pectate lyase; Region: Pectate_lyase; pfam03211 226900003185 Sodium:solute symporter family; Region: SSF; cl00456 226900003186 anthranilate synthase component I; Provisional; Region: PRK13570 226900003187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 226900003188 chorismate binding enzyme; Region: Chorismate_bind; cl10555 226900003189 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 226900003190 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 226900003191 glutamine binding [chemical binding]; other site 226900003192 catalytic triad [active] 226900003193 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 226900003194 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900003195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900003196 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 226900003197 active site 226900003198 ribulose/triose binding site [chemical binding]; other site 226900003199 phosphate binding site [ion binding]; other site 226900003200 substrate (anthranilate) binding pocket [chemical binding]; other site 226900003201 product (indole) binding pocket [chemical binding]; other site 226900003202 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 226900003203 active site 226900003204 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 226900003205 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 226900003206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003207 catalytic residue [active] 226900003208 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 226900003209 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 226900003210 substrate binding site [chemical binding]; other site 226900003211 active site 226900003212 catalytic residues [active] 226900003213 heterodimer interface [polypeptide binding]; other site 226900003214 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 226900003215 L-lactate permease; Region: Lactate_perm; cl00701 226900003216 glycolate transporter; Provisional; Region: PRK09695 226900003217 Uncharacterized conserved protein [Function unknown]; Region: COG5634 226900003218 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 226900003219 Double zinc ribbon; Region: DZR; pfam12773 226900003220 Predicted membrane protein [Function unknown]; Region: COG4640 226900003221 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226900003222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003223 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 226900003224 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 226900003225 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900003226 NADPH bind site [chemical binding]; other site 226900003227 putative FMN binding site [chemical binding]; other site 226900003228 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900003229 putative FMN binding site [chemical binding]; other site 226900003230 NADPH bind site [chemical binding]; other site 226900003231 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 226900003232 YcaO-like family; Region: YcaO; cl09146 226900003233 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 226900003234 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 226900003235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900003236 E3 interaction surface; other site 226900003237 lipoyl attachment site [posttranslational modification]; other site 226900003238 e3 binding domain; Region: E3_binding; pfam02817 226900003239 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 226900003240 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 226900003241 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 226900003242 TPP-binding site [chemical binding]; other site 226900003243 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 226900003244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900003245 salt bridge; other site 226900003246 non-specific DNA binding site [nucleotide binding]; other site 226900003247 sequence-specific DNA binding site [nucleotide binding]; other site 226900003248 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 226900003249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003250 Walker A/P-loop; other site 226900003251 ATP binding site [chemical binding]; other site 226900003252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003253 ABC transporter signature motif; other site 226900003254 Walker B; other site 226900003255 D-loop; other site 226900003256 H-loop/switch region; other site 226900003257 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 226900003258 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 226900003259 Protein of unknown function DUF91; Region: DUF91; cl00709 226900003260 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 226900003261 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900003262 Phage integrase family; Region: Phage_integrase; pfam00589 226900003263 Int/Topo IB signature motif; other site 226900003264 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 226900003265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003266 S-adenosylmethionine binding site [chemical binding]; other site 226900003267 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900003268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900003269 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900003270 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900003271 Catalytic site [active] 226900003272 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 226900003273 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 226900003274 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 226900003275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900003276 non-specific DNA binding site [nucleotide binding]; other site 226900003277 salt bridge; other site 226900003278 sequence-specific DNA binding site [nucleotide binding]; other site 226900003279 Anti-repressor SinI; Region: SinI; pfam08671 226900003280 Anti-repressor SinI; Region: SinI; pfam08671 226900003281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900003282 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 226900003283 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 226900003284 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 226900003285 NAD(P) binding site [chemical binding]; other site 226900003286 catalytic residues [active] 226900003287 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 226900003288 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 226900003289 Walker A/P-loop; other site 226900003290 ATP binding site [chemical binding]; other site 226900003291 Q-loop/lid; other site 226900003292 ABC transporter signature motif; other site 226900003293 Walker B; other site 226900003294 D-loop; other site 226900003295 H-loop/switch region; other site 226900003296 TOBE domain; Region: TOBE_2; cl01440 226900003297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003298 dimer interface [polypeptide binding]; other site 226900003299 conserved gate region; other site 226900003300 putative PBP binding loops; other site 226900003301 ABC-ATPase subunit interface; other site 226900003302 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226900003303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003304 dimer interface [polypeptide binding]; other site 226900003305 conserved gate region; other site 226900003306 putative PBP binding loops; other site 226900003307 ABC-ATPase subunit interface; other site 226900003308 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226900003309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900003310 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226900003311 active site 226900003312 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 226900003313 Protein export membrane protein; Region: SecD_SecF; cl14618 226900003314 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226900003315 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 226900003316 active site 226900003317 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 226900003318 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 226900003319 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 226900003320 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 226900003321 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 226900003322 Cysteine-rich domain; Region: CCG; pfam02754 226900003323 Cysteine-rich domain; Region: CCG; pfam02754 226900003324 FAD binding domain; Region: FAD_binding_4; pfam01565 226900003325 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 226900003326 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 226900003327 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 226900003328 Uncharacterized conserved protein [Function unknown]; Region: COG3391 226900003329 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226900003330 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226900003331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900003332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003333 active site 226900003334 phosphorylation site [posttranslational modification] 226900003335 intermolecular recognition site; other site 226900003336 dimerization interface [polypeptide binding]; other site 226900003337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900003338 DNA binding site [nucleotide binding] 226900003339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900003340 dimerization interface [polypeptide binding]; other site 226900003341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003342 dimer interface [polypeptide binding]; other site 226900003343 phosphorylation site [posttranslational modification] 226900003344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003345 ATP binding site [chemical binding]; other site 226900003346 Mg2+ binding site [ion binding]; other site 226900003347 G-X-G motif; other site 226900003348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900003349 DNA-binding site [nucleotide binding]; DNA binding site 226900003350 FCD domain; Region: FCD; cl11656 226900003351 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 226900003352 Cysteine-rich domain; Region: CCG; pfam02754 226900003353 Cysteine-rich domain; Region: CCG; pfam02754 226900003354 iron-sulfur cluster-binding protein; Region: TIGR00273 226900003355 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 226900003356 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 226900003357 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 226900003358 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 226900003359 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 226900003360 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 226900003361 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 226900003362 Integral membrane protein TerC family; Region: TerC; cl10468 226900003363 Cation transport protein; Region: TrkH; cl10514 226900003364 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226900003365 Cation transport protein; Region: TrkH; cl10514 226900003366 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900003367 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 226900003368 dimer interaction site [polypeptide binding]; other site 226900003369 substrate-binding tunnel; other site 226900003370 active site 226900003371 catalytic site [active] 226900003372 substrate binding site [chemical binding]; other site 226900003373 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 226900003374 Helix-turn-helix domains; Region: HTH; cl00088 226900003375 Helix-turn-helix domains; Region: HTH; cl00088 226900003376 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 226900003377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900003378 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226900003379 NAD(P) binding site [chemical binding]; other site 226900003380 homotetramer interface [polypeptide binding]; other site 226900003381 homodimer interface [polypeptide binding]; other site 226900003382 active site 226900003383 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 226900003384 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 226900003385 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 226900003386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900003387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003388 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226900003389 Cation transport protein; Region: TrkH; cl10514 226900003390 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 226900003391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900003392 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 226900003393 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 226900003394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003395 Walker A/P-loop; other site 226900003396 ATP binding site [chemical binding]; other site 226900003397 Q-loop/lid; other site 226900003398 ABC transporter signature motif; other site 226900003399 Walker B; other site 226900003400 D-loop; other site 226900003401 H-loop/switch region; other site 226900003402 TOBE domain; Region: TOBE_2; cl01440 226900003403 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 226900003404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003405 dimer interface [polypeptide binding]; other site 226900003406 conserved gate region; other site 226900003407 putative PBP binding loops; other site 226900003408 ABC-ATPase subunit interface; other site 226900003409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003410 dimer interface [polypeptide binding]; other site 226900003411 conserved gate region; other site 226900003412 putative PBP binding loops; other site 226900003413 ABC-ATPase subunit interface; other site 226900003414 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 226900003415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900003416 motif II; other site 226900003417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900003418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900003419 catalytic residue [active] 226900003420 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 226900003421 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900003422 Helix-turn-helix domains; Region: HTH; cl00088 226900003423 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900003424 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900003425 heme-binding site [chemical binding]; other site 226900003426 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003427 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 226900003428 Leucine-rich repeats; other site 226900003429 Substrate binding site [chemical binding]; other site 226900003430 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003431 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003432 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003433 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003434 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003435 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003436 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003437 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003438 LRR adjacent; Region: LRR_adjacent; pfam08191 226900003439 S-layer homology domain; Region: SLH; pfam00395 226900003440 S-layer homology domain; Region: SLH; pfam00395 226900003441 S-layer homology domain; Region: SLH; pfam00395 226900003442 similar to Methylthioribose salvage protein ( aldolase) 226900003443 FOG: CBS domain [General function prediction only]; Region: COG0517 226900003444 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226900003445 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 226900003446 NodB motif; other site 226900003447 putative active site [active] 226900003448 putative catalytic site [active] 226900003449 Zn binding site [ion binding]; other site 226900003450 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900003451 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 226900003452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003453 dimer interface [polypeptide binding]; other site 226900003454 phosphorylation site [posttranslational modification] 226900003455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003456 ATP binding site [chemical binding]; other site 226900003457 Mg2+ binding site [ion binding]; other site 226900003458 G-X-G motif; other site 226900003459 Helix-turn-helix domains; Region: HTH; cl00088 226900003460 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 226900003461 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 226900003462 active site 226900003463 Zn binding site [ion binding]; other site 226900003464 DinB superfamily; Region: DinB_2; cl00986 226900003465 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900003466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900003467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003468 dimer interface [polypeptide binding]; other site 226900003469 phosphorylation site [posttranslational modification] 226900003470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003471 ATP binding site [chemical binding]; other site 226900003472 Mg2+ binding site [ion binding]; other site 226900003473 G-X-G motif; other site 226900003474 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 226900003475 Ligand Binding Site [chemical binding]; other site 226900003476 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 226900003477 active site 226900003478 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 226900003479 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 226900003480 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 226900003481 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 226900003482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900003483 Coenzyme A binding pocket [chemical binding]; other site 226900003484 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900003485 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 226900003486 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 226900003487 Class I ribonucleotide reductase; Region: RNR_I; cd01679 226900003488 active site 226900003489 dimer interface [polypeptide binding]; other site 226900003490 catalytic residues [active] 226900003491 effector binding site; other site 226900003492 R2 peptide binding site; other site 226900003493 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 226900003494 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 226900003495 dimer interface [polypeptide binding]; other site 226900003496 putative radical transfer pathway; other site 226900003497 diiron center [ion binding]; other site 226900003498 tyrosyl radical; other site 226900003499 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900003500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900003501 DNA-binding site [nucleotide binding]; DNA binding site 226900003502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900003503 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900003504 Walker A/P-loop; other site 226900003505 ATP binding site [chemical binding]; other site 226900003506 Q-loop/lid; other site 226900003507 ABC transporter signature motif; other site 226900003508 Walker B; other site 226900003509 D-loop; other site 226900003510 H-loop/switch region; other site 226900003511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900003512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003513 Walker A/P-loop; other site 226900003514 ATP binding site [chemical binding]; other site 226900003515 Q-loop/lid; other site 226900003516 ABC transporter signature motif; other site 226900003517 Walker B; other site 226900003518 D-loop; other site 226900003519 H-loop/switch region; other site 226900003520 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900003521 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900003522 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900003523 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 226900003524 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900003525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900003526 putative DNA binding site [nucleotide binding]; other site 226900003527 putative Zn2+ binding site [ion binding]; other site 226900003528 Helix-turn-helix domains; Region: HTH; cl00088 226900003529 Uncharacterized conserved protein [Function unknown]; Region: COG2128 226900003530 Arabidopsis thaliana protein of unknown function (DUF821); Region: DUF821; pfam05686 226900003531 Isochorismatase family; Region: Isochorismatase; pfam00857 226900003532 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900003533 catalytic triad [active] 226900003534 conserved cis-peptide bond; other site 226900003535 SseB protein; Region: SseB; cl06279 226900003536 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 226900003537 dimer interface [polypeptide binding]; other site 226900003538 catalytic triad [active] 226900003539 Nitronate monooxygenase; Region: NMO; pfam03060 226900003540 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 226900003541 FMN binding site [chemical binding]; other site 226900003542 substrate binding site [chemical binding]; other site 226900003543 putative catalytic residue [active] 226900003544 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 226900003545 DltD N-terminal region; Region: DltD_N; pfam04915 226900003546 DltD central region; Region: DltD_M; pfam04918 226900003547 DltD C-terminal region; Region: DltD_C; pfam04914 226900003548 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900003549 MBOAT family; Region: MBOAT; cl00738 226900003550 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 226900003551 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900003552 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 226900003553 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900003554 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 226900003555 metal binding site [ion binding]; metal-binding site 226900003556 dimer interface [polypeptide binding]; other site 226900003557 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900003558 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900003559 Phosphotransferase enzyme family; Region: APH; pfam01636 226900003560 active site 226900003561 substrate binding site [chemical binding]; other site 226900003562 ATP binding site [chemical binding]; other site 226900003563 multidrug efflux protein; Reviewed; Region: PRK01766 226900003564 MatE; Region: MatE; cl10513 226900003565 MatE; Region: MatE; cl10513 226900003566 Bacitracin resistance protein BacA; Region: BacA; cl00858 226900003567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900003568 catalytic residues [active] 226900003569 Regulatory protein YrvL; Region: YrvL; pfam14184 226900003570 Helix-turn-helix domains; Region: HTH; cl00088 226900003571 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900003572 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226900003573 Cation transport protein; Region: TrkH; cl10514 226900003574 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900003575 Uncharacterised protein family (UPF0180); Region: UPF0180; cl04214 226900003576 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 226900003577 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900003578 homodimer interface [polypeptide binding]; other site 226900003579 substrate-cofactor binding pocket; other site 226900003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003581 Aminotransferase class IV; Region: Aminotran_4; pfam01063 226900003582 catalytic residue [active] 226900003583 similar to Acetolactate synthase large subunit; EC_number 4.1.3.18 226900003584 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 226900003585 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 226900003586 putative valine binding site [chemical binding]; other site 226900003587 dimer interface [polypeptide binding]; other site 226900003588 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 226900003589 ketol-acid reductoisomerase; Provisional; Region: PRK05479 226900003590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003591 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 226900003592 2-isopropylmalate synthase; Validated; Region: PRK00915 226900003593 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 226900003594 active site 226900003595 catalytic residues [active] 226900003596 metal binding site [ion binding]; metal-binding site 226900003597 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 226900003598 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 226900003599 tartrate dehydrogenase; Provisional; Region: PRK08194 226900003600 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 226900003601 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 226900003602 substrate binding site [chemical binding]; other site 226900003603 ligand binding site [chemical binding]; other site 226900003604 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 226900003605 substrate binding site [chemical binding]; other site 226900003606 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 226900003607 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 226900003608 dimer interface [polypeptide binding]; other site 226900003609 motif 1; other site 226900003610 active site 226900003611 motif 2; other site 226900003612 motif 3; other site 226900003613 ATP phosphoribosyltransferase; Region: HisG; cl15266 226900003614 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 226900003615 histidinol dehydrogenase; Region: hisD; TIGR00069 226900003616 NAD binding site [chemical binding]; other site 226900003617 dimerization interface [polypeptide binding]; other site 226900003618 product binding site; other site 226900003619 substrate binding site [chemical binding]; other site 226900003620 zinc binding site [ion binding]; other site 226900003621 catalytic residues [active] 226900003622 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 226900003623 putative active site pocket [active] 226900003624 4-fold oligomerization interface [polypeptide binding]; other site 226900003625 metal binding residues [ion binding]; metal-binding site 226900003626 3-fold/trimer interface [polypeptide binding]; other site 226900003627 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 226900003628 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 226900003629 putative active site [active] 226900003630 oxyanion strand; other site 226900003631 catalytic triad [active] 226900003632 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 226900003633 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 226900003634 catalytic residues [active] 226900003635 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 226900003636 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 226900003637 substrate binding site [chemical binding]; other site 226900003638 glutamase interaction surface [polypeptide binding]; other site 226900003639 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 226900003640 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900003641 histidinol-phosphatase; Validated; Region: PRK06740 226900003642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900003643 glyoxylate reductase; Reviewed; Region: PRK13243 226900003644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003645 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900003646 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900003647 Sulfatase; Region: Sulfatase; cl10460 226900003648 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 226900003649 diaminopimelate decarboxylase; Region: lysA; TIGR01048 226900003650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 226900003651 active site 226900003652 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900003653 substrate binding site [chemical binding]; other site 226900003654 catalytic residues [active] 226900003655 dimer interface [polypeptide binding]; other site 226900003656 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 226900003657 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226900003658 Active Sites [active] 226900003659 ATP-sulfurylase; Region: ATPS; cd00517 226900003660 active site 226900003661 HXXH motif; other site 226900003662 flexible loop; other site 226900003663 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 226900003664 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 226900003665 ligand-binding site [chemical binding]; other site 226900003666 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 226900003667 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900003668 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900003669 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 226900003670 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 226900003671 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 226900003672 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 226900003673 putative active site [active] 226900003674 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 226900003675 putative active site [active] 226900003676 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 226900003677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003678 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 226900003679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 226900003680 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900003681 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900003682 Protein of unknown function (DUF402); Region: DUF402; cl00979 226900003683 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 226900003684 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900003685 PspA/IM30 family; Region: PspA_IM30; pfam04012 226900003686 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 226900003687 Histidine kinase; Region: HisKA_3; pfam07730 226900003688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003689 ATP binding site [chemical binding]; other site 226900003690 Mg2+ binding site [ion binding]; other site 226900003691 G-X-G motif; other site 226900003692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003694 active site 226900003695 phosphorylation site [posttranslational modification] 226900003696 intermolecular recognition site; other site 226900003697 dimerization interface [polypeptide binding]; other site 226900003698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900003699 DNA binding residues [nucleotide binding] 226900003700 dimerization interface [polypeptide binding]; other site 226900003701 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900003702 E3 interaction surface; other site 226900003703 lipoyl attachment site [posttranslational modification]; other site 226900003704 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900003705 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900003706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003707 S-adenosylmethionine binding site [chemical binding]; other site 226900003708 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 226900003709 active site 226900003710 putative substrate binding region [chemical binding]; other site 226900003711 hypothetical protein; Provisional; Region: PRK06770 226900003712 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 226900003713 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 226900003714 heme-binding site [chemical binding]; other site 226900003715 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 226900003716 FAD binding pocket [chemical binding]; other site 226900003717 FAD binding motif [chemical binding]; other site 226900003718 phosphate binding motif [ion binding]; other site 226900003719 beta-alpha-beta structure motif; other site 226900003720 NAD binding pocket [chemical binding]; other site 226900003721 Heme binding pocket [chemical binding]; other site 226900003722 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900003723 ligand binding site [chemical binding]; other site 226900003724 flexible hinge region; other site 226900003725 Helix-turn-helix domains; Region: HTH; cl00088 226900003726 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900003727 Phosphate transporter family; Region: PHO4; cl00396 226900003728 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 226900003729 Transglycosylase; Region: Transgly; cl07896 226900003730 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900003731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900003732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900003733 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226900003734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003735 dimer interface [polypeptide binding]; other site 226900003736 phosphorylation site [posttranslational modification] 226900003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003738 ATP binding site [chemical binding]; other site 226900003739 Mg2+ binding site [ion binding]; other site 226900003740 G-X-G motif; other site 226900003741 Protein of unknown function DUF72; Region: DUF72; cl00777 226900003742 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 226900003743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900003744 Phage integrase family; Region: Phage_integrase; pfam00589 226900003745 DNA binding site [nucleotide binding] 226900003746 Int/Topo IB signature motif; other site 226900003747 active site 226900003748 similar to Two component system histidine kinase; EC_number 2.7.3.- 226900003749 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 226900003750 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 226900003751 Predicted integral membrane protein [Function unknown]; Region: COG0392 226900003752 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 226900003753 Uncharacterized conserved protein [Function unknown]; Region: COG2898 226900003754 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 226900003755 periplasmic chaperone; Provisional; Region: PRK10780 226900003756 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900003757 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900003758 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900003759 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900003760 Nucleoside recognition; Region: Gate; cl00486 226900003761 Nucleoside recognition; Region: Gate; cl00486 226900003762 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900003763 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900003764 RNA binding surface [nucleotide binding]; other site 226900003765 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 226900003766 active site 226900003767 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900003768 catalytic residues [active] 226900003769 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 226900003770 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 226900003771 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226900003772 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226900003773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900003774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003775 active site 226900003776 phosphorylation site [posttranslational modification] 226900003777 intermolecular recognition site; other site 226900003778 dimerization interface [polypeptide binding]; other site 226900003779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900003780 DNA binding site [nucleotide binding] 226900003781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900003782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900003783 dimerization interface [polypeptide binding]; other site 226900003784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900003785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003786 dimer interface [polypeptide binding]; other site 226900003787 phosphorylation site [posttranslational modification] 226900003788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003789 ATP binding site [chemical binding]; other site 226900003790 Mg2+ binding site [ion binding]; other site 226900003791 G-X-G motif; other site 226900003792 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 226900003793 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900003794 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900003795 putative peptidoglycan binding site; other site 226900003796 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900003797 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 226900003798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 226900003799 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900003800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900003801 ATP binding site [chemical binding]; other site 226900003802 putative Mg++ binding site [ion binding]; other site 226900003803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900003804 nucleotide binding region [chemical binding]; other site 226900003805 ATP-binding site [chemical binding]; other site 226900003806 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900003807 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900003808 putative peptidoglycan binding site; other site 226900003809 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900003810 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900003811 putative active site [active] 226900003812 putative metal binding site [ion binding]; other site 226900003813 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 226900003814 DNA binding residues [nucleotide binding] 226900003815 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 226900003816 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 226900003817 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 226900003818 NAD(P) binding site [chemical binding]; other site 226900003819 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 226900003820 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900003821 amidase catalytic site [active] 226900003822 Zn binding residues [ion binding]; other site 226900003823 substrate binding site [chemical binding]; other site 226900003824 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 226900003825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003827 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 226900003828 active site 226900003829 homotetramer interface [polypeptide binding]; other site 226900003830 homodimer interface [polypeptide binding]; other site 226900003831 cytidylate kinase; Provisional; Region: cmk; PRK00023 226900003832 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 226900003833 CMP-binding site; other site 226900003834 The sites determining sugar specificity; other site 226900003835 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 226900003836 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 226900003837 RNA binding site [nucleotide binding]; other site 226900003838 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 226900003839 RNA binding site [nucleotide binding]; other site 226900003840 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 226900003841 RNA binding site [nucleotide binding]; other site 226900003842 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 226900003843 RNA binding site [nucleotide binding]; other site 226900003844 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 226900003845 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 226900003846 homotetramer interface [polypeptide binding]; other site 226900003847 FMN binding site [chemical binding]; other site 226900003848 homodimer contacts [polypeptide binding]; other site 226900003849 putative active site [active] 226900003850 putative substrate binding site [chemical binding]; other site 226900003851 YpzI-like protein; Region: YpzI; pfam14140 226900003852 YIEGIA protein; Region: YIEGIA; pfam14045 226900003853 GTP-binding protein Der; Reviewed; Region: PRK00093 226900003854 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 226900003855 G1 box; other site 226900003856 GTP/Mg2+ binding site [chemical binding]; other site 226900003857 Switch I region; other site 226900003858 G2 box; other site 226900003859 Switch II region; other site 226900003860 G3 box; other site 226900003861 G4 box; other site 226900003862 G5 box; other site 226900003863 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 226900003864 G1 box; other site 226900003865 GTP/Mg2+ binding site [chemical binding]; other site 226900003866 Switch I region; other site 226900003867 G2 box; other site 226900003868 G3 box; other site 226900003869 Switch II region; other site 226900003870 G4 box; other site 226900003871 G5 box; other site 226900003872 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 226900003873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003874 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 226900003875 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 226900003876 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 226900003877 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 226900003878 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 226900003879 IHF dimer interface [polypeptide binding]; other site 226900003880 IHF - DNA interface [nucleotide binding]; other site 226900003881 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 226900003882 homodecamer interface [polypeptide binding]; other site 226900003883 GTP cyclohydrolase I; Provisional; Region: PLN03044 226900003884 active site 226900003885 putative catalytic site residues [active] 226900003886 zinc binding site [ion binding]; other site 226900003887 GTP-CH-I/GFRP interaction surface; other site 226900003888 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 226900003889 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 226900003890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003891 S-adenosylmethionine binding site [chemical binding]; other site 226900003892 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 226900003893 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226900003894 substrate binding pocket [chemical binding]; other site 226900003895 chain length determination region; other site 226900003896 substrate-Mg2+ binding site; other site 226900003897 catalytic residues [active] 226900003898 aspartate-rich region 1; other site 226900003899 active site lid residues [active] 226900003900 aspartate-rich region 2; other site 226900003901 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 226900003902 active site 226900003903 multimer interface [polypeptide binding]; other site 226900003904 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226900003905 Tetramer interface [polypeptide binding]; other site 226900003906 active site 226900003907 FMN-binding site [chemical binding]; other site 226900003908 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 226900003909 active site 226900003910 dimer interface [polypeptide binding]; other site 226900003911 metal binding site [ion binding]; metal-binding site 226900003912 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 226900003913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900003914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003915 homodimer interface [polypeptide binding]; other site 226900003916 catalytic residue [active] 226900003917 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 226900003918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 226900003919 binding surface 226900003920 TPR motif; other site 226900003921 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 226900003922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900003923 binding surface 226900003924 TPR motif; other site 226900003925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900003926 binding surface 226900003927 TPR motif; other site 226900003928 hypothetical protein; Provisional; Region: PRK03636 226900003929 UPF0302 domain; Region: UPF0302; pfam08864 226900003930 IDEAL domain; Region: IDEAL; cl07452 226900003931 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 226900003932 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 226900003933 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 226900003934 iron-sulfur cluster [ion binding]; other site 226900003935 [2Fe-2S] cluster binding site [ion binding]; other site 226900003936 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 226900003937 interchain domain interface [polypeptide binding]; other site 226900003938 intrachain domain interface; other site 226900003939 heme bH binding site [chemical binding]; other site 226900003940 Qi binding site; other site 226900003941 heme bL binding site [chemical binding]; other site 226900003942 Qo binding site; other site 226900003943 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 226900003944 Cytochrome c; Region: Cytochrom_C; cl11414 226900003945 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 226900003946 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 226900003947 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 226900003948 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 226900003949 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 226900003950 active site 226900003951 Fe-S cluster binding site [ion binding]; other site 226900003952 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900003953 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900003954 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900003955 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900003956 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900003957 dihydrodipicolinate reductase; Provisional; Region: PRK00048 226900003958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003959 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 226900003960 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 226900003961 active site 226900003962 dimer interfaces [polypeptide binding]; other site 226900003963 catalytic residues [active] 226900003964 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 226900003965 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 226900003966 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 226900003967 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 226900003968 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 226900003969 active site 226900003970 NTP binding site [chemical binding]; other site 226900003971 metal binding triad [ion binding]; metal-binding site 226900003972 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 226900003973 Helix-turn-helix domains; Region: HTH; cl00088 226900003974 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 226900003975 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 226900003976 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 226900003977 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 226900003978 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 226900003979 oligomerization interface [polypeptide binding]; other site 226900003980 active site 226900003981 metal binding site [ion binding]; metal-binding site 226900003982 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 226900003983 Pantoate-beta-alanine ligase; Region: PanC; cd00560 226900003984 active site 226900003985 ATP-binding site [chemical binding]; other site 226900003986 pantoate-binding site; other site 226900003987 HXXH motif; other site 226900003988 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 226900003989 tetramerization interface [polypeptide binding]; other site 226900003990 active site 226900003991 similar to ATP-dependent helicase, DinG family 226900003992 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 226900003993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 226900003994 aspartate aminotransferase; Provisional; Region: PRK05764 226900003995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900003996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003997 homodimer interface [polypeptide binding]; other site 226900003998 catalytic residue [active] 226900003999 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226900004000 Helix-turn-helix domains; Region: HTH; cl00088 226900004001 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900004002 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 226900004003 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900004004 minor groove reading motif; other site 226900004005 helix-hairpin-helix signature motif; other site 226900004006 substrate binding pocket [chemical binding]; other site 226900004007 active site 226900004008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900004009 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 226900004010 Transposase IS200 like; Region: Y1_Tnp; cl00848 226900004011 Probable transposase; Region: OrfB_IS605; pfam01385 226900004012 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900004013 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900004014 Transglycosylase; Region: Transgly; cl07896 226900004015 Recombination protein U; Region: RecU; cl01314 226900004016 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 226900004017 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 226900004018 YppF-like protein; Region: YppF; pfam14178 226900004019 YppG-like protein; Region: YppG; pfam14179 226900004020 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 226900004021 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 226900004022 cell division protein GpsB; Provisional; Region: PRK14127 226900004023 DivIVA domain; Region: DivI1A_domain; TIGR03544 226900004024 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 226900004025 THUMP domain; Region: THUMP; cl12076 226900004026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900004027 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 226900004028 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 226900004029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004031 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 226900004032 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 226900004033 active site 226900004034 Zn binding site [ion binding]; other site 226900004035 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900004036 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900004037 active site 226900004038 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900004039 Permease family; Region: Xan_ur_permease; cl00967 226900004040 Predicted membrane protein [Function unknown]; Region: COG2311 226900004041 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900004042 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900004043 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 226900004044 G1 box; other site 226900004045 GTP/Mg2+ binding site [chemical binding]; other site 226900004046 Switch I region; other site 226900004047 G2 box; other site 226900004048 Switch II region; other site 226900004049 G3 box; other site 226900004050 G4 box; other site 226900004051 GTPase [General function prediction only]; Region: Era; COG1159 226900004052 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 226900004053 G1 box; other site 226900004054 GTP/Mg2+ binding site [chemical binding]; other site 226900004055 Switch I region; other site 226900004056 G2 box; other site 226900004057 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 226900004058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004059 Coenzyme A binding pocket [chemical binding]; other site 226900004060 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 226900004061 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 226900004062 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 226900004063 active site residue [active] 226900004064 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 226900004065 active site residue [active] 226900004066 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 226900004067 Predicted membrane protein [Function unknown]; Region: COG3766 226900004068 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 226900004069 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 226900004070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900004071 5'-3' exonuclease; Region: 53EXOc; smart00475 226900004072 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226900004073 active site 226900004074 metal binding site 1 [ion binding]; metal-binding site 226900004075 putative 5' ssDNA interaction site; other site 226900004076 metal binding site 3; metal-binding site 226900004077 metal binding site 2 [ion binding]; metal-binding site 226900004078 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226900004079 putative DNA binding site [nucleotide binding]; other site 226900004080 putative metal binding site [ion binding]; other site 226900004081 OpgC protein; Region: OpgC_C; cl00792 226900004082 Chain length determinant protein; Region: Wzz; cl01623 226900004083 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900004084 Bacterial sugar transferase; Region: Bac_transf; cl00939 226900004085 MatE; Region: MatE; cl10513 226900004086 colanic acid exporter; Provisional; Region: PRK10459 226900004087 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226900004088 O-Antigen ligase; Region: Wzy_C; cl04850 226900004089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900004090 active site 226900004091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900004092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226900004093 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226900004094 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004095 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004096 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004097 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004098 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004099 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004100 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004101 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004102 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004103 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004104 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004105 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004106 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004107 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004108 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004109 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004110 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004111 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004112 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004113 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004114 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004115 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004116 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004117 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004118 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004119 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004120 Domain of unknown function DUF11; Region: DUF11; cl15273 226900004121 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900004122 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900004123 catalytic triad [active] 226900004124 conserved cis-peptide bond; other site 226900004125 EamA-like transporter family; Region: EamA; cl01037 226900004126 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900004127 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 226900004128 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900004129 active site 226900004130 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 226900004131 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 226900004132 active site 226900004133 catalytic residues [active] 226900004134 QueT transporter; Region: QueT; cl01932 226900004135 hypothetical protein; Validated; Region: PRK07708 226900004136 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 226900004137 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900004138 active site 226900004139 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 226900004140 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 226900004141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900004142 DNA-binding site [nucleotide binding]; DNA binding site 226900004143 RNA-binding motif; other site 226900004144 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 226900004145 LysE type translocator; Region: LysE; cl00565 226900004146 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 226900004147 Protein of unknown function, DUF485; Region: DUF485; cl01231 226900004148 Sodium:solute symporter family; Region: SSF; cl00456 226900004149 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 226900004150 aminotransferase; Validated; Region: PRK07678 226900004151 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900004152 inhibitor-cofactor binding pocket; inhibition site 226900004153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004154 catalytic residue [active] 226900004155 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 226900004156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900004157 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 226900004158 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900004159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900004160 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 226900004161 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900004162 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226900004163 DNA binding residues [nucleotide binding] 226900004164 drug binding residues [chemical binding]; other site 226900004165 dimer interface [polypeptide binding]; other site 226900004166 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900004167 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 226900004168 MatE; Region: MatE; cl10513 226900004169 MatE; Region: MatE; cl10513 226900004170 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900004171 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900004172 putative active site [active] 226900004173 Tic20-like protein; Region: Tic20; pfam09685 226900004174 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 226900004175 dimer interface [polypeptide binding]; other site 226900004176 FMN binding site [chemical binding]; other site 226900004177 NADPH bind site [chemical binding]; other site 226900004178 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900004179 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004181 putative substrate translocation pore; other site 226900004182 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900004183 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 226900004184 Sm1 motif; other site 226900004185 D3 - B interaction site; other site 226900004186 D1 - D2 interaction site; other site 226900004187 Hfq - Hfq interaction site; other site 226900004188 RNA binding pocket [nucleotide binding]; other site 226900004189 Sm2 motif; other site 226900004190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900004191 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 226900004192 flagellar motor protein MotS; Reviewed; Region: PRK06742 226900004193 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226900004194 ligand binding site [chemical binding]; other site 226900004195 Response regulator receiver domain; Region: Response_reg; pfam00072 226900004196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004197 active site 226900004198 phosphorylation site [posttranslational modification] 226900004199 intermolecular recognition site; other site 226900004200 dimerization interface [polypeptide binding]; other site 226900004201 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 226900004202 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 226900004203 putative binding surface; other site 226900004204 active site 226900004205 P2 response regulator binding domain; Region: P2; pfam07194 226900004206 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 226900004207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004208 ATP binding site [chemical binding]; other site 226900004209 Mg2+ binding site [ion binding]; other site 226900004210 G-X-G motif; other site 226900004211 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 226900004212 flagellar motor switch protein; Reviewed; Region: PRK06782 226900004213 CheC-like family; Region: CheC; pfam04509 226900004214 CheC-like family; Region: CheC; pfam04509 226900004215 CheC-like family; Region: CheC; pfam04509 226900004216 CheC-like family; Region: CheC; pfam04509 226900004217 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 226900004218 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 226900004219 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 226900004220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900004221 Protein of unknown function (DUF327); Region: DUF327; cl00753 226900004222 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 226900004223 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 226900004224 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 226900004225 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004226 flagellar capping protein; Validated; Region: fliD; PRK06798 226900004227 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 226900004228 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 226900004229 Flagellar protein FliS; Region: FliS; cl00654 226900004230 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 226900004231 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 226900004232 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 226900004233 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 226900004234 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 226900004235 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 226900004236 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 226900004237 FliG C-terminal domain; Region: FliG_C; pfam01706 226900004238 flagellar assembly protein H; Validated; Region: fliH; PRK06800 226900004239 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 226900004240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004241 Walker A motif; other site 226900004242 ATP binding site [chemical binding]; other site 226900004243 Walker B motif; other site 226900004244 similar to hypothetical protein 226900004245 Flagellar hook capping protein; Region: FlgD; cl04347 226900004246 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 226900004247 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 226900004248 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 226900004249 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 226900004250 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 226900004251 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 226900004252 putative CheA interaction surface; other site 226900004253 Response regulator receiver domain; Region: Response_reg; pfam00072 226900004254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004255 active site 226900004256 phosphorylation site [posttranslational modification] 226900004257 intermolecular recognition site; other site 226900004258 dimerization interface [polypeptide binding]; other site 226900004259 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 226900004260 flagellin; Provisional; Region: PRK12807 226900004261 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004262 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004263 flagellin; Provisional; Region: PRK12807 226900004264 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004265 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004266 flagellin; Provisional; Region: PRK12807 226900004267 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004268 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004269 flagellin; Provisional; Region: PRK12807 226900004270 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004271 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004272 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 226900004273 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 226900004274 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226900004275 catalytic residue [active] 226900004276 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 226900004277 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 226900004278 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 226900004279 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 226900004280 FliP family; Region: FliP; cl00593 226900004281 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 226900004282 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 226900004283 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 226900004284 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 226900004285 similar to Flagellar biosynthesis protein flhA 226900004286 similar to Flagellar biosynthesis protein flhF 226900004287 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 226900004288 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 226900004289 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 226900004290 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 226900004291 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 226900004292 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 226900004293 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900004294 Predicted transcriptional regulators [Transcription]; Region: COG1378 226900004295 Helix-turn-helix domains; Region: HTH; cl00088 226900004296 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900004297 C-terminal domain interface [polypeptide binding]; other site 226900004298 sugar binding site [chemical binding]; other site 226900004299 AzlC protein; Region: AzlC; cl00570 226900004300 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 226900004301 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226900004302 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900004303 Small acid-soluble spore protein H family; Region: SspH; cl06949 226900004304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004305 non-specific DNA binding site [nucleotide binding]; other site 226900004306 salt bridge; other site 226900004307 sequence-specific DNA binding site [nucleotide binding]; other site 226900004308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004309 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004310 putative substrate translocation pore; other site 226900004311 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 226900004312 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 226900004313 Helix-turn-helix domains; Region: HTH; cl00088 226900004314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900004315 dimerization interface [polypeptide binding]; other site 226900004316 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226900004317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004318 Walker A/P-loop; other site 226900004319 ATP binding site [chemical binding]; other site 226900004320 Q-loop/lid; other site 226900004321 ABC transporter signature motif; other site 226900004322 Walker B; other site 226900004323 D-loop; other site 226900004324 H-loop/switch region; other site 226900004325 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226900004326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900004327 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 226900004328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900004329 dimer interface [polypeptide binding]; other site 226900004330 conserved gate region; other site 226900004331 putative PBP binding loops; other site 226900004332 ABC-ATPase subunit interface; other site 226900004333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900004334 dimer interface [polypeptide binding]; other site 226900004335 conserved gate region; other site 226900004336 putative PBP binding loops; other site 226900004337 ABC-ATPase subunit interface; other site 226900004338 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 226900004339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900004340 Beta-Casp domain; Region: Beta-Casp; cl12567 226900004341 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 226900004342 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 226900004343 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 226900004344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900004345 catalytic core [active] 226900004346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900004347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900004348 hypothetical protein; Provisional; Region: PRK09272 226900004349 Helix-turn-helix domains; Region: HTH; cl00088 226900004350 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900004351 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226900004352 active site 226900004353 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 226900004354 dimer interface [polypeptide binding]; other site 226900004355 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900004356 Ligand Binding Site [chemical binding]; other site 226900004357 Molecular Tunnel; other site 226900004358 RNA polymerase factor sigma-70; Validated; Region: PRK06811 226900004359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900004360 DNA binding residues [nucleotide binding] 226900004361 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 226900004362 VPS10 domain; Region: VPS10; smart00602 226900004363 VPS10 domain; Region: VPS10; smart00602 226900004364 Cation efflux family; Region: Cation_efflux; cl00316 226900004365 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226900004366 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 226900004367 Transcriptional regulators [Transcription]; Region: GntR; COG1802 226900004368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900004369 DNA-binding site [nucleotide binding]; DNA binding site 226900004370 FCD domain; Region: FCD; cl11656 226900004371 EamA-like transporter family; Region: EamA; cl01037 226900004372 EamA-like transporter family; Region: EamA; cl01037 226900004373 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900004374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004376 G4 box; other site 226900004377 G5 box; other site 226900004378 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 226900004379 Predicted permease; Region: DUF318; cl00487 226900004380 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 226900004381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004382 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900004383 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900004384 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 226900004385 DNA binding residues [nucleotide binding] 226900004386 putative dimer interface [polypeptide binding]; other site 226900004387 short chain dehydrogenase; Provisional; Region: PRK06123 226900004388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004389 NAD(P) binding site [chemical binding]; other site 226900004390 active site 226900004391 fumarate hydratase; Reviewed; Region: fumC; PRK00485 226900004392 Class II fumarases; Region: Fumarase_classII; cd01362 226900004393 active site 226900004394 tetramer interface [polypeptide binding]; other site 226900004395 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 226900004396 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 226900004397 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226900004398 MatE; Region: MatE; cl10513 226900004399 MatE; Region: MatE; cl10513 226900004400 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 226900004401 active site pocket [active] 226900004402 oxyanion hole [active] 226900004403 catalytic triad [active] 226900004404 active site nucleophile [active] 226900004405 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 226900004406 Helix-turn-helix domains; Region: HTH; cl00088 226900004407 Peptidase family M48; Region: Peptidase_M48; cl12018 226900004408 LysE type translocator; Region: LysE; cl00565 226900004409 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900004410 catalytic residues [active] 226900004411 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 226900004412 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900004413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004414 non-specific DNA binding site [nucleotide binding]; other site 226900004415 salt bridge; other site 226900004416 sequence-specific DNA binding site [nucleotide binding]; other site 226900004417 Cupin domain; Region: Cupin_2; cl09118 226900004418 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 226900004419 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 226900004420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900004421 catalytic residue [active] 226900004422 Protein of unknown function (DUF445); Region: DUF445; pfam04286 226900004423 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 226900004424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900004425 DNA binding residues [nucleotide binding] 226900004426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900004427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004428 active site 226900004429 phosphorylation site [posttranslational modification] 226900004430 intermolecular recognition site; other site 226900004431 dimerization interface [polypeptide binding]; other site 226900004432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900004433 DNA binding residues [nucleotide binding] 226900004434 dimerization interface [polypeptide binding]; other site 226900004435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900004436 Histidine kinase; Region: HisKA_3; pfam07730 226900004437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004438 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 226900004439 Walker A/P-loop; other site 226900004440 ATP binding site [chemical binding]; other site 226900004441 Q-loop/lid; other site 226900004442 ABC transporter signature motif; other site 226900004443 Walker B; other site 226900004444 D-loop; other site 226900004445 H-loop/switch region; other site 226900004446 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900004447 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900004448 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900004449 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900004450 putative active site [active] 226900004451 catalytic site [active] 226900004452 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900004453 putative active site [active] 226900004454 catalytic site [active] 226900004455 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226900004456 putative nucleotide binding site [chemical binding]; other site 226900004457 uridine monophosphate binding site [chemical binding]; other site 226900004458 homohexameric interface [polypeptide binding]; other site 226900004459 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900004460 aspartate ammonia-lyase; Provisional; Region: PRK14515 226900004461 Aspartase; Region: Aspartase; cd01357 226900004462 active sites [active] 226900004463 tetramer interface [polypeptide binding]; other site 226900004464 malate dehydrogenase; Provisional; Region: PRK13529 226900004465 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900004466 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 226900004467 NAD(P) binding site [chemical binding]; other site 226900004468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900004469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004470 ATP binding site [chemical binding]; other site 226900004471 Mg2+ binding site [ion binding]; other site 226900004472 G-X-G motif; other site 226900004473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004474 Response regulator receiver domain; Region: Response_reg; pfam00072 226900004475 active site 226900004476 phosphorylation site [posttranslational modification] 226900004477 intermolecular recognition site; other site 226900004478 dimerization interface [polypeptide binding]; other site 226900004479 YcbB domain; Region: YcbB; pfam08664 226900004480 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 226900004481 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226900004482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900004483 ATP binding site [chemical binding]; other site 226900004484 putative Mg++ binding site [ion binding]; other site 226900004485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900004486 nucleotide binding region [chemical binding]; other site 226900004487 ATP-binding site [chemical binding]; other site 226900004488 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 226900004489 dimer interface [polypeptide binding]; other site 226900004490 active site 226900004491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 226900004492 putative dimer interface [polypeptide binding]; other site 226900004493 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900004494 aspartate kinase; Reviewed; Region: PRK06635 226900004495 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 226900004496 putative nucleotide binding site [chemical binding]; other site 226900004497 putative catalytic residues [active] 226900004498 putative Mg ion binding site [ion binding]; other site 226900004499 putative aspartate binding site [chemical binding]; other site 226900004500 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 226900004501 putative allosteric regulatory site; other site 226900004502 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 226900004503 putative allosteric regulatory residue; other site 226900004504 DoxX-like family; Region: DoxX_3; pfam13781 226900004505 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 226900004506 YndJ-like protein; Region: YndJ; pfam14158 226900004507 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900004508 putative active site [active] 226900004509 nucleotide binding site [chemical binding]; other site 226900004510 nudix motif; other site 226900004511 putative metal binding site [ion binding]; other site 226900004512 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004514 putative substrate translocation pore; other site 226900004515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004516 active site 226900004517 Helix-turn-helix domains; Region: HTH; cl00088 226900004518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900004520 putative substrate translocation pore; other site 226900004521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004522 putative substrate translocation pore; other site 226900004523 CDK-activating kinase assembly factor MAT1; Region: cdk7; TIGR00570 226900004524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004525 putative substrate translocation pore; other site 226900004526 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 226900004527 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226900004528 dimer interface [polypeptide binding]; other site 226900004529 active site 226900004530 CoA binding pocket [chemical binding]; other site 226900004531 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226900004532 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 226900004533 G1 box; other site 226900004534 GTP/Mg2+ binding site [chemical binding]; other site 226900004535 Switch I region; other site 226900004536 G2 box; other site 226900004537 G3 box; other site 226900004538 Switch II region; other site 226900004539 G4 box; other site 226900004540 G5 box; other site 226900004541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004542 putative substrate translocation pore; other site 226900004543 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 226900004544 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900004545 dimer interface [polypeptide binding]; other site 226900004546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004547 catalytic residue [active] 226900004548 Predicted acetyltransferase [General function prediction only]; Region: COG3981 226900004549 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 226900004550 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 226900004551 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 226900004552 NodB motif; other site 226900004553 putative active site [active] 226900004554 putative catalytic site [active] 226900004555 putative Zn binding site [ion binding]; other site 226900004556 Mor transcription activator family; Region: Mor; cl02360 226900004557 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900004558 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 226900004559 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 226900004560 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 226900004561 similar to Short chain type dehydrogenase/reductase; EC_number 1.-.-.- 226900004562 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900004563 homodimer interface [polypeptide binding]; other site 226900004564 substrate-cofactor binding pocket; other site 226900004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004566 Aminotransferase class IV; Region: Aminotran_4; pfam01063 226900004567 catalytic residue [active] 226900004568 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 226900004569 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226900004570 PYR/PP interface [polypeptide binding]; other site 226900004571 dimer interface [polypeptide binding]; other site 226900004572 TPP binding site [chemical binding]; other site 226900004573 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 226900004574 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 226900004575 TPP-binding site [chemical binding]; other site 226900004576 dimer interface [polypeptide binding]; other site 226900004577 similar to Acetolactate synthase large subunit; EC_number 4.1.3.18 226900004578 ketol-acid reductoisomerase; Provisional; Region: PRK05479 226900004579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004580 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 226900004581 Dehydratase family; Region: ILVD_EDD; cl00340 226900004582 threonine dehydratase; Validated; Region: PRK08639 226900004583 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 226900004584 tetramer interface [polypeptide binding]; other site 226900004585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004586 catalytic residue [active] 226900004587 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 226900004588 putative Ile/Val binding site [chemical binding]; other site 226900004589 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 226900004590 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226900004591 putative active site [active] 226900004592 putative metal binding site [ion binding]; other site 226900004593 Protein of unknown function (DUF554); Region: DUF554; cl00784 226900004594 Clp protease ATP binding subunit; Region: clpC; CHL00095 226900004595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004596 Coenzyme A binding pocket [chemical binding]; other site 226900004597 drug efflux system protein MdtG; Provisional; Region: PRK09874 226900004598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004599 putative substrate translocation pore; other site 226900004600 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 226900004601 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 226900004602 putative active site [active] 226900004603 metal binding site [ion binding]; metal-binding site 226900004604 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226900004605 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900004606 LytTr DNA-binding domain; Region: LytTR; cl04498 226900004607 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900004608 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 226900004609 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900004610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004611 Coenzyme A binding pocket [chemical binding]; other site 226900004612 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 226900004613 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 226900004614 active site 226900004615 putative substrate binding pocket [chemical binding]; other site 226900004616 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900004617 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900004618 peptide binding site [polypeptide binding]; other site 226900004619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900004620 S-adenosylmethionine binding site [chemical binding]; other site 226900004621 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 226900004622 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900004623 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900004624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004626 active site 226900004627 phosphorylation site [posttranslational modification] 226900004628 intermolecular recognition site; other site 226900004629 dimerization interface [polypeptide binding]; other site 226900004630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900004631 DNA binding site [nucleotide binding] 226900004632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900004633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900004634 dimerization interface [polypeptide binding]; other site 226900004635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900004636 dimer interface [polypeptide binding]; other site 226900004637 phosphorylation site [posttranslational modification] 226900004638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004639 ATP binding site [chemical binding]; other site 226900004640 Mg2+ binding site [ion binding]; other site 226900004641 G-X-G motif; other site 226900004642 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900004643 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 226900004644 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 226900004645 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 226900004646 active site residue [active] 226900004647 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 226900004648 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 226900004649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004650 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226900004651 Amino acid permease; Region: AA_permease; cl00524 226900004652 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004653 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004654 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004655 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900004656 isoform II; Region: PAF-AH_p_II; pfam03403 226900004657 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900004658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900004659 Helix-turn-helix domains; Region: HTH; cl00088 226900004660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004661 Coenzyme A binding pocket [chemical binding]; other site 226900004662 Domain of unknown function (DUF74); Region: DUF74; cl00426 226900004663 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900004664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900004665 Helix-turn-helix domains; Region: HTH; cl00088 226900004666 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900004667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 226900004668 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900004669 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 226900004670 intersubunit interface [polypeptide binding]; other site 226900004671 active site 226900004672 catalytic residue [active] 226900004673 nucleoside transporter; Region: nupC; TIGR00804 226900004674 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900004675 Nucleoside recognition; Region: Gate; cl00486 226900004676 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900004677 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 226900004678 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900004679 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900004680 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 226900004681 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226900004682 active site 226900004683 catalytic motif [active] 226900004684 Zn binding site [ion binding]; other site 226900004685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900004686 putative transposase OrfB; Reviewed; Region: PHA02517 226900004687 Integrase core domain; Region: rve; cl01316 226900004688 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 226900004689 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 226900004690 proline aminopeptidase P II; Provisional; Region: PRK10879 226900004691 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 226900004692 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 226900004693 active site 226900004694 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 226900004695 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 226900004696 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 226900004697 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 226900004698 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 226900004699 DNA topoisomerase III; Provisional; Region: PRK07726 226900004700 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226900004701 active site 226900004702 putative interdomain interaction site [polypeptide binding]; other site 226900004703 putative metal-binding site [ion binding]; other site 226900004704 putative nucleotide binding site [chemical binding]; other site 226900004705 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900004706 domain I; other site 226900004707 DNA binding groove [nucleotide binding] 226900004708 phosphate binding site [ion binding]; other site 226900004709 domain II; other site 226900004710 domain III; other site 226900004711 nucleotide binding site [chemical binding]; other site 226900004712 catalytic site [active] 226900004713 domain IV; other site 226900004714 DNA topoisomerase III; Validated; Region: PRK08173 226900004715 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900004716 Membrane transport protein; Region: Mem_trans; cl09117 226900004717 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900004718 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900004719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900004720 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 226900004721 dimer interface [polypeptide binding]; other site 226900004722 substrate binding site [chemical binding]; other site 226900004723 metal binding site [ion binding]; metal-binding site 226900004724 Copper resistance protein CopC; Region: CopC; cl01012 226900004725 Copper resistance protein D; Region: CopD; cl00563 226900004726 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 226900004727 EamA-like transporter family; Region: EamA; cl01037 226900004728 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900004729 EamA-like transporter family; Region: EamA; cl01037 226900004730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900004731 Helix-turn-helix domains; Region: HTH; cl00088 226900004732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900004733 dimerization interface [polypeptide binding]; other site 226900004734 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900004735 Helix-turn-helix domains; Region: HTH; cl00088 226900004736 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 226900004737 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 226900004738 catalytic residues [active] 226900004739 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900004740 dimer interface [polypeptide binding]; other site 226900004741 FMN binding site [chemical binding]; other site 226900004742 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 226900004743 Bacteriophage phBC6A51; identified by comparison with Bacillus anthracis; and Bacillus thuringiensis 226900004744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900004745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004746 non-specific DNA binding site [nucleotide binding]; other site 226900004747 salt bridge; other site 226900004748 sequence-specific DNA binding site [nucleotide binding]; other site 226900004749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004750 non-specific DNA binding site [nucleotide binding]; other site 226900004751 salt bridge; other site 226900004752 sequence-specific DNA binding site [nucleotide binding]; other site 226900004753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004754 non-specific DNA binding site [nucleotide binding]; other site 226900004755 salt bridge; other site 226900004756 sequence-specific DNA binding site [nucleotide binding]; other site 226900004757 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 226900004758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004759 Walker A/P-loop; other site 226900004760 ATP binding site [chemical binding]; other site 226900004761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004762 Walker B; other site 226900004763 D-loop; other site 226900004764 H-loop/switch region; other site 226900004765 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900004766 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900004767 active site 226900004768 metal binding site [ion binding]; metal-binding site 226900004769 DNA binding site [nucleotide binding] 226900004770 UvsW helicase; Provisional; Region: uvsW; PHA02558 226900004771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900004772 ATP binding site [chemical binding]; other site 226900004773 putative Mg++ binding site [ion binding]; other site 226900004774 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 226900004775 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 226900004776 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 226900004777 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 226900004778 active site 226900004779 substrate binding site [chemical binding]; other site 226900004780 catalytic site [active] 226900004781 DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication; Region: DNA_pol_A_plastid_like; cd08640 226900004782 active site 226900004783 DNA binding site [nucleotide binding] 226900004784 catalytic site [active] 226900004785 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 226900004786 YopX protein; Region: YopX; cl09859 226900004787 HNH endonuclease; Region: HNH_3; pfam13392 226900004788 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900004789 Protein of unknown function (DUF3205); Region: DUF3205; pfam11471 226900004790 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 226900004791 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 226900004792 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 226900004793 Head fiber protein; Region: Phage_head_fibr; pfam11133 226900004794 similar to Phage protein 226900004795 Phage major tail protein 2; Region: Phage_tail_2; cl11463 226900004796 Phage protein; Region: DUF3647; cl10335 226900004797 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 226900004798 Phage-related protein [Function unknown]; Region: COG5412 226900004799 similar to Phage protein 226900004800 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 226900004801 Haemolysin XhlA; Region: XhlA; pfam10779 226900004802 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900004803 amidase catalytic site [active] 226900004804 Zn binding residues [ion binding]; other site 226900004805 substrate binding site [chemical binding]; other site 226900004806 Bacterial SH3 domain; Region: SH3_3; cl02551 226900004807 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 226900004808 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 226900004809 Helix-turn-helix domains; Region: HTH; cl00088 226900004810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004811 non-specific DNA binding site [nucleotide binding]; other site 226900004812 salt bridge; other site 226900004813 sequence-specific DNA binding site [nucleotide binding]; other site 226900004814 similar to DNA segregation ATPase FtsK/SpoIIIE and related proteins 226900004815 Replication-relaxation; Region: Replic_Relax; pfam13814 226900004816 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 226900004817 catalytic residues [active] 226900004818 catalytic nucleophile [active] 226900004819 Recombinase; Region: Recombinase; pfam07508 226900004820 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 226900004821 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900004822 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900004823 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900004824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900004825 NAD binding site [chemical binding]; other site 226900004826 dimer interface [polypeptide binding]; other site 226900004827 substrate binding site [chemical binding]; other site 226900004828 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 226900004829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004830 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900004831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004832 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 226900004833 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 226900004834 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 226900004835 putative ligand binding site [chemical binding]; other site 226900004836 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 226900004837 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 226900004838 Walker A/P-loop; other site 226900004839 ATP binding site [chemical binding]; other site 226900004840 Q-loop/lid; other site 226900004841 ABC transporter signature motif; other site 226900004842 Walker B; other site 226900004843 D-loop; other site 226900004844 H-loop/switch region; other site 226900004845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 226900004846 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 226900004847 Walker A/P-loop; other site 226900004848 ATP binding site [chemical binding]; other site 226900004849 Q-loop/lid; other site 226900004850 ABC transporter signature motif; other site 226900004851 Walker B; other site 226900004852 D-loop; other site 226900004853 H-loop/switch region; other site 226900004854 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 226900004855 TM-ABC transporter signature motif; other site 226900004856 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 226900004857 TM-ABC transporter signature motif; other site 226900004858 Helix-turn-helix domains; Region: HTH; cl00088 226900004859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900004860 dimerization interface [polypeptide binding]; other site 226900004861 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 226900004862 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900004863 Helix-turn-helix domains; Region: HTH; cl00088 226900004864 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 226900004865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 226900004866 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 226900004867 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 226900004868 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 226900004869 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226900004870 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900004871 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 226900004872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004873 Walker A/P-loop; other site 226900004874 ATP binding site [chemical binding]; other site 226900004875 Q-loop/lid; other site 226900004876 ABC transporter signature motif; other site 226900004877 Walker B; other site 226900004878 D-loop; other site 226900004879 H-loop/switch region; other site 226900004880 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 226900004881 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900004882 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 226900004883 Walker A/P-loop; other site 226900004884 ATP binding site [chemical binding]; other site 226900004885 Q-loop/lid; other site 226900004886 ABC transporter signature motif; other site 226900004887 Walker B; other site 226900004888 D-loop; other site 226900004889 H-loop/switch region; other site 226900004890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900004891 active site 226900004892 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900004893 active site 226900004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900004895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900004896 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 226900004897 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226900004898 inhibitor-cofactor binding pocket; inhibition site 226900004899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004900 catalytic residue [active] 226900004901 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226900004902 trimer interface [polypeptide binding]; other site 226900004903 active site 226900004904 substrate binding site [chemical binding]; other site 226900004905 CoA binding site [chemical binding]; other site 226900004906 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900004907 putative dimer interface [polypeptide binding]; other site 226900004908 catalytic triad [active] 226900004909 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900004910 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900004911 dimer interface [polypeptide binding]; other site 226900004912 FMN binding site [chemical binding]; other site 226900004913 Bacterial SH3 domain; Region: SH3_3; cl02551 226900004914 Bacterial SH3 domain; Region: SH3_3; cl02551 226900004915 Bacterial SH3 domain; Region: SH3_3; cl02551 226900004916 NlpC/P60 family; Region: NLPC_P60; cl11438 226900004917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900004918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900004919 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900004920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900004921 Walker A/P-loop; other site 226900004922 ATP binding site [chemical binding]; other site 226900004923 Q-loop/lid; other site 226900004924 ABC transporter signature motif; other site 226900004925 Walker B; other site 226900004926 D-loop; other site 226900004927 H-loop/switch region; other site 226900004928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900004929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004930 active site 226900004931 phosphorylation site [posttranslational modification] 226900004932 intermolecular recognition site; other site 226900004933 dimerization interface [polypeptide binding]; other site 226900004934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900004935 DNA binding site [nucleotide binding] 226900004936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900004937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900004938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900004939 dimer interface [polypeptide binding]; other site 226900004940 phosphorylation site [posttranslational modification] 226900004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004942 ATP binding site [chemical binding]; other site 226900004943 Mg2+ binding site [ion binding]; other site 226900004944 G-X-G motif; other site 226900004945 classical (c) SDRs; Region: SDR_c; cd05233 226900004946 NAD(P) binding site [chemical binding]; other site 226900004947 active site 226900004948 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 226900004949 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 226900004950 NodB motif; other site 226900004951 active site 226900004952 catalytic site [active] 226900004953 metal binding site [ion binding]; metal-binding site 226900004954 SdpI/YhfL protein family; Region: SdpI; pfam13630 226900004955 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 226900004956 nudix motif; other site 226900004957 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 226900004958 homoserine dehydrogenase; Provisional; Region: PRK06349 226900004959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004960 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900004961 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 226900004962 threonine synthase; Reviewed; Region: PRK06721 226900004963 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 226900004964 homodimer interface [polypeptide binding]; other site 226900004965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004966 catalytic residue [active] 226900004967 homoserine kinase; Provisional; Region: PRK01212 226900004968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 226900004969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226900004970 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 226900004971 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900004972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004974 active site 226900004975 phosphorylation site [posttranslational modification] 226900004976 intermolecular recognition site; other site 226900004977 dimerization interface [polypeptide binding]; other site 226900004978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900004979 DNA binding site [nucleotide binding] 226900004980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900004981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900004982 dimer interface [polypeptide binding]; other site 226900004983 phosphorylation site [posttranslational modification] 226900004984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004985 ATP binding site [chemical binding]; other site 226900004986 Mg2+ binding site [ion binding]; other site 226900004987 G-X-G motif; other site 226900004988 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900004989 NodB motif; other site 226900004990 active site 226900004991 catalytic site [active] 226900004992 Zn binding site [ion binding]; other site 226900004993 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 226900004994 MgtC family; Region: MgtC; cl12207 226900004995 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900004996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004997 Coenzyme A binding pocket [chemical binding]; other site 226900004998 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 226900004999 IucA / IucC family; Region: IucA_IucC; pfam04183 226900005000 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 226900005001 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 226900005002 IucA / IucC family; Region: IucA_IucC; pfam04183 226900005003 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 226900005004 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900005005 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900005006 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 226900005007 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226900005008 AP (apurinic/apyrimidinic) site pocket; other site 226900005009 DNA interaction; other site 226900005010 Metal-binding active site; metal-binding site 226900005011 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900005012 similar to Tetracycline resistance protein 226900005013 LysE type translocator; Region: LysE; cl00565 226900005014 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900005015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900005016 DNA-binding site [nucleotide binding]; DNA binding site 226900005017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900005018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005019 homodimer interface [polypeptide binding]; other site 226900005020 catalytic residue [active] 226900005021 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 226900005022 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 226900005023 active site 226900005024 nucleophile elbow; other site 226900005025 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 226900005026 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 226900005027 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 226900005028 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 226900005029 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900005030 nudix motif; other site 226900005031 NAD+ synthetase; Region: nadE; TIGR00552 226900005032 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 226900005033 homodimer interface [polypeptide binding]; other site 226900005034 NAD binding pocket [chemical binding]; other site 226900005035 ATP binding pocket [chemical binding]; other site 226900005036 Mg binding site [ion binding]; other site 226900005037 active-site loop [active] 226900005038 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900005039 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900005040 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 226900005041 active site 226900005042 catalytic residues [active] 226900005043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900005044 dimerization interface [polypeptide binding]; other site 226900005045 putative DNA binding site [nucleotide binding]; other site 226900005046 putative Zn2+ binding site [ion binding]; other site 226900005047 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900005048 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900005049 active site 226900005050 catalytic tetrad [active] 226900005051 similar to Chloramphenicol resistance protein 226900005052 Protein of unknown function (DUF805); Region: DUF805; cl01224 226900005053 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 226900005054 DinB superfamily; Region: DinB_2; cl00986 226900005055 GTPase RsgA; Reviewed; Region: PRK01889 226900005056 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 226900005057 GTPase/OB domain interface [polypeptide binding]; other site 226900005058 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226900005059 GTP/Mg2+ binding site [chemical binding]; other site 226900005060 G4 box; other site 226900005061 G5 box; other site 226900005062 G1 box; other site 226900005063 Switch I region; other site 226900005064 G2 box; other site 226900005065 G3 box; other site 226900005066 Switch II region; other site 226900005067 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 226900005068 Cache domain; Region: Cache_1; pfam02743 226900005069 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 226900005070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900005071 dimerization interface [polypeptide binding]; other site 226900005072 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900005073 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900005074 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 226900005075 Uncharacterized membrane protein [Function unknown]; Region: COG3949 226900005076 Ferritin-like domain; Region: Ferritin; pfam00210 226900005077 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226900005078 dimerization interface [polypeptide binding]; other site 226900005079 DPS ferroxidase diiron center [ion binding]; other site 226900005080 ion pore; other site 226900005081 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 226900005082 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900005083 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 226900005084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 226900005085 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 226900005086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005087 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 226900005088 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900005089 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005090 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900005091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900005092 active site 226900005093 catalytic tetrad [active] 226900005094 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900005095 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 226900005096 P-loop, Walker A motif; other site 226900005097 Base recognition motif; other site 226900005098 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 226900005099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005100 Coenzyme A binding pocket [chemical binding]; other site 226900005101 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 226900005102 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 226900005103 metal binding site [ion binding]; metal-binding site 226900005104 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 226900005105 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900005106 NAD binding site [chemical binding]; other site 226900005107 active site 226900005108 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 226900005109 active site 226900005110 FMN binding site [chemical binding]; other site 226900005111 substrate binding site [chemical binding]; other site 226900005112 homotetramer interface [polypeptide binding]; other site 226900005113 catalytic residue [active] 226900005114 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 226900005115 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226900005116 DNA binding site [nucleotide binding] 226900005117 active site 226900005118 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 226900005119 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900005120 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900005121 peptide binding site [polypeptide binding]; other site 226900005122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900005123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900005124 active site 226900005125 metal binding site [ion binding]; metal-binding site 226900005126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900005128 catalytic core [active] 226900005129 CotH protein; Region: CotH; pfam08757 226900005130 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 226900005131 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 226900005132 nudix motif; other site 226900005133 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900005134 MatE; Region: MatE; cl10513 226900005135 MviN-like protein; Region: MVIN; pfam03023 226900005136 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 226900005137 Predicted permease; Region: DUF318; cl00487 226900005138 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 226900005139 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 226900005140 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900005141 putative active site [active] 226900005142 catalytic site [active] 226900005143 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900005144 putative active site [active] 226900005145 catalytic site [active] 226900005146 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 226900005147 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 226900005148 NAD binding site [chemical binding]; other site 226900005149 substrate binding site [chemical binding]; other site 226900005150 putative active site [active] 226900005151 Protein of unknown function (DUF456); Region: DUF456; cl01069 226900005152 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900005153 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900005154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900005155 Transporter associated domain; Region: CorC_HlyC; cl08393 226900005156 FOG: CBS domain [General function prediction only]; Region: COG0517 226900005157 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226900005158 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900005159 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 226900005160 dimer interface [polypeptide binding]; other site 226900005161 putative tRNA-binding site [nucleotide binding]; other site 226900005162 DinB superfamily; Region: DinB_2; cl00986 226900005163 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 226900005164 stage II sporulation protein P; Region: spore_II_P; TIGR02867 226900005165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005166 Coenzyme A binding pocket [chemical binding]; other site 226900005167 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005168 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 226900005169 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900005170 nudix motif; other site 226900005171 amidase; Provisional; Region: PRK06828 226900005172 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 226900005173 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900005174 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 226900005175 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 226900005176 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 226900005177 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 226900005178 stage II sporulation protein P; Region: spore_II_P; TIGR02867 226900005179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900005180 catalytic core [active] 226900005181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005182 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900005183 active site 226900005184 motif I; other site 226900005185 motif II; other site 226900005186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005187 multidrug resistance protein MdtH; Provisional; Region: PRK11646 226900005188 DinB superfamily; Region: DinB_2; cl00986 226900005189 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226900005190 alanine racemase; Reviewed; Region: alr; PRK00053 226900005191 active site 226900005192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900005193 dimer interface [polypeptide binding]; other site 226900005194 substrate binding site [chemical binding]; other site 226900005195 catalytic residues [active] 226900005196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005197 Coenzyme A binding pocket [chemical binding]; other site 226900005198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005199 Coenzyme A binding pocket [chemical binding]; other site 226900005200 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900005201 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 226900005202 glycosyltransferase, MGT family; Region: MGT; TIGR01426 226900005203 active site 226900005204 TDP-binding site; other site 226900005205 acceptor substrate-binding pocket; other site 226900005206 homodimer interface [polypeptide binding]; other site 226900005207 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900005208 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900005209 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900005210 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900005211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900005212 DNA-binding site [nucleotide binding]; DNA binding site 226900005213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900005214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005215 homodimer interface [polypeptide binding]; other site 226900005216 catalytic residue [active] 226900005217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005218 Coenzyme A binding pocket [chemical binding]; other site 226900005219 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900005220 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 226900005221 active site 226900005222 metal binding site [ion binding]; metal-binding site 226900005223 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 226900005224 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900005225 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005226 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005227 hypothetical protein; Provisional; Region: PRK13679 226900005228 putative acetyltransferase; Provisional; Region: PRK03624 226900005229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005230 Coenzyme A binding pocket [chemical binding]; other site 226900005231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005232 Coenzyme A binding pocket [chemical binding]; other site 226900005233 Proteins of 100 residues with WXG; Region: WXG100; cl02005 226900005234 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900005235 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 226900005236 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 226900005237 CD99 antigen like protein 2; Region: CD99L2; pfam12301 226900005238 Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266 226900005239 Predicted membrane protein essB; Region: essB; cl01868 226900005240 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 226900005241 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 226900005242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005244 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005245 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 226900005246 active site flap/lid [active] 226900005247 nucleophilic elbow; other site 226900005248 catalytic triad [active] 226900005249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 226900005250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 226900005251 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 226900005252 nucleophilic elbow; other site 226900005253 catalytic triad; other site 226900005254 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005255 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005256 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005257 Predicted acetyltransferase [General function prediction only]; Region: COG3393 226900005258 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005259 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900005260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900005261 S-adenosylmethionine binding site [chemical binding]; other site 226900005262 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 226900005263 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 226900005264 Potassium binding sites [ion binding]; other site 226900005265 Cesium cation binding sites [ion binding]; other site 226900005266 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900005267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900005268 ATP binding site [chemical binding]; other site 226900005269 Mg++ binding site [ion binding]; other site 226900005270 motif III; other site 226900005271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900005272 nucleotide binding region [chemical binding]; other site 226900005273 ATP-binding site [chemical binding]; other site 226900005274 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226900005275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900005276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 226900005277 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900005278 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 226900005279 NADP binding site [chemical binding]; other site 226900005280 dimer interface [polypeptide binding]; other site 226900005281 RNA polymerase sigma factor; Provisional; Region: PRK12543 226900005282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900005283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900005284 DNA binding residues [nucleotide binding] 226900005285 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 226900005286 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900005287 similar to Metal-dependent hydrolase; EC_number 3.-.-.- 226900005288 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 226900005289 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 226900005290 catalytic residues [active] 226900005291 dimer interface [polypeptide binding]; other site 226900005292 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 226900005293 similar to hypothetical Cytosolic Protein 226900005294 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900005295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900005296 Walker A motif; other site 226900005297 ATP binding site [chemical binding]; other site 226900005298 Walker B motif; other site 226900005299 arginine finger; other site 226900005300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005301 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 226900005302 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 226900005303 [4Fe-4S] binding site [ion binding]; other site 226900005304 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 226900005305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 226900005306 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 226900005307 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 226900005308 molybdopterin cofactor binding site; other site 226900005309 nitrate reductase, beta subunit; Region: narH; TIGR01660 226900005310 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 226900005311 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 226900005312 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226900005313 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900005314 ligand binding site [chemical binding]; other site 226900005315 flexible hinge region; other site 226900005316 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 226900005317 putative switch regulator; other site 226900005318 non-specific DNA interactions [nucleotide binding]; other site 226900005319 DNA binding site [nucleotide binding] 226900005320 sequence specific DNA binding site [nucleotide binding]; other site 226900005321 putative cAMP binding site [chemical binding]; other site 226900005322 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 226900005323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900005324 FeS/SAM binding site; other site 226900005325 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900005326 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 226900005327 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900005328 ATP binding site [chemical binding]; other site 226900005329 substrate interface [chemical binding]; other site 226900005330 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900005331 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900005332 dimer interface [polypeptide binding]; other site 226900005333 putative functional site; other site 226900005334 putative MPT binding site; other site 226900005335 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900005336 MoaE homodimer interface [polypeptide binding]; other site 226900005337 MoaD interaction [polypeptide binding]; other site 226900005338 active site residues [active] 226900005339 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900005340 MoaE interaction surface [polypeptide binding]; other site 226900005341 MoeB interaction surface [polypeptide binding]; other site 226900005342 thiocarboxylated glycine; other site 226900005343 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 226900005344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005345 putative substrate translocation pore; other site 226900005346 Membrane transport protein; Region: Mem_trans; cl09117 226900005347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005348 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 226900005349 putative active site [active] 226900005350 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 226900005351 putative active site [active] 226900005352 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 226900005353 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 226900005354 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 226900005355 [2Fe-2S] cluster binding site [ion binding]; other site 226900005356 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 226900005357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005358 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 226900005359 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 226900005360 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900005361 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 226900005362 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 226900005363 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 226900005364 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900005365 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 226900005366 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900005367 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 226900005368 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 226900005369 YolD-like protein; Region: YolD; pfam08863 226900005370 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 226900005371 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 226900005372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900005373 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900005374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005375 Walker A/P-loop; other site 226900005376 ATP binding site [chemical binding]; other site 226900005377 Q-loop/lid; other site 226900005378 ABC transporter signature motif; other site 226900005379 Walker B; other site 226900005380 D-loop; other site 226900005381 H-loop/switch region; other site 226900005382 ABC transporter; Region: ABC_tran_2; pfam12848 226900005383 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900005384 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 226900005385 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 226900005386 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226900005387 dimer interface [polypeptide binding]; other site 226900005388 ssDNA binding site [nucleotide binding]; other site 226900005389 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900005390 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 226900005391 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 226900005392 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 226900005393 Protein of unknown function, DUF393; Region: DUF393; cl01136 226900005394 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 226900005395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900005396 similar to Arginyl-tRNA synthetase; EC_number 6.1.1.19 226900005397 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 226900005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900005399 hypothetical protein; Provisional; Region: PRK08317 226900005400 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 226900005401 putative active site [active] 226900005402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005403 binding surface 226900005404 TPR motif; other site 226900005405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005406 binding surface 226900005407 TPR motif; other site 226900005408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005409 binding surface 226900005410 TPR motif; other site 226900005411 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 226900005412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005413 binding surface 226900005414 TPR motif; other site 226900005415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005416 binding surface 226900005417 TPR motif; other site 226900005418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005419 binding surface 226900005420 TPR motif; other site 226900005421 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 226900005422 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226900005423 HIGH motif; other site 226900005424 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226900005425 active site 226900005426 KMSKS motif; other site 226900005427 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 226900005428 tRNA binding surface [nucleotide binding]; other site 226900005429 anticodon binding site; other site 226900005430 Predicted membrane protein [Function unknown]; Region: COG2311 226900005431 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900005432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900005433 Helix-turn-helix domains; Region: HTH; cl00088 226900005434 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900005435 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900005436 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 226900005437 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 226900005438 Zn binding site [ion binding]; other site 226900005439 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 226900005440 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 226900005441 Dimer interface [polypeptide binding]; other site 226900005442 anticodon binding site; other site 226900005443 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226900005444 homodimer interface [polypeptide binding]; other site 226900005445 motif 1; other site 226900005446 motif 2; other site 226900005447 active site 226900005448 motif 3; other site 226900005449 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 226900005450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900005451 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 226900005452 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 226900005453 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900005454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005455 motif II; other site 226900005456 Citrate transporter; Region: CitMHS; pfam03600 226900005457 GntP family permease; Region: GntP_permease; cl15264 226900005458 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 226900005459 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 226900005460 putative active site [active] 226900005461 metal binding site [ion binding]; metal-binding site 226900005462 aspartate racemase; Region: asp_race; TIGR00035 226900005463 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900005464 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 226900005465 homodimer interaction site [polypeptide binding]; other site 226900005466 cofactor binding site; other site 226900005467 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005469 Coenzyme A binding pocket [chemical binding]; other site 226900005470 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 226900005471 Helix-turn-helix domains; Region: HTH; cl00088 226900005472 hypothetical protein; Validated; Region: PRK06769 226900005473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005474 active site 226900005475 motif I; other site 226900005476 motif II; other site 226900005477 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005479 Coenzyme A binding pocket [chemical binding]; other site 226900005480 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226900005481 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900005482 Walker A/P-loop; other site 226900005483 ATP binding site [chemical binding]; other site 226900005484 Q-loop/lid; other site 226900005485 ABC transporter signature motif; other site 226900005486 Walker B; other site 226900005487 D-loop; other site 226900005488 H-loop/switch region; other site 226900005489 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 226900005490 YpjP-like protein; Region: YpjP; pfam14005 226900005491 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900005492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005493 motif II; other site 226900005494 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900005495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900005496 active site 226900005497 metal binding site [ion binding]; metal-binding site 226900005498 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 226900005499 Phosphotransferase enzyme family; Region: APH; pfam01636 226900005500 active site 226900005501 substrate binding site [chemical binding]; other site 226900005502 ATP binding site [chemical binding]; other site 226900005503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900005504 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 226900005505 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 226900005506 dimerization interface [polypeptide binding]; other site 226900005507 active site 226900005508 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 226900005509 folate binding site [chemical binding]; other site 226900005510 NADP+ binding site [chemical binding]; other site 226900005511 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 226900005512 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900005513 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900005514 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900005515 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900005516 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226900005517 putative acyl-acceptor binding pocket; other site 226900005518 Haemolysin-III related; Region: HlyIII; cl03831 226900005519 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 226900005520 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 226900005521 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 226900005522 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 226900005523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900005524 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 226900005525 Cu(I) binding site [ion binding]; other site 226900005526 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 226900005527 putative dimer interface [polypeptide binding]; other site 226900005528 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 226900005529 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226900005530 active site 226900005531 dimer interface [polypeptide binding]; other site 226900005532 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900005533 Ligand Binding Site [chemical binding]; other site 226900005534 Molecular Tunnel; other site 226900005535 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005536 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900005537 active site 226900005538 metal binding site [ion binding]; metal-binding site 226900005539 Bacterial SH3 domain; Region: SH3_3; cl02551 226900005540 Bacterial SH3 domain; Region: SH3_3; cl02551 226900005541 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900005542 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900005543 siderophore binding site; other site 226900005544 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900005545 homodimer interface [polypeptide binding]; other site 226900005546 substrate-cofactor binding pocket; other site 226900005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005548 Aminotransferase class IV; Region: Aminotran_4; pfam01063 226900005549 catalytic residue [active] 226900005550 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 226900005551 FMN binding site [chemical binding]; other site 226900005552 dimer interface [polypeptide binding]; other site 226900005553 Isochorismatase family; Region: Isochorismatase; pfam00857 226900005554 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900005555 catalytic triad [active] 226900005556 conserved cis-peptide bond; other site 226900005557 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226900005558 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 226900005559 putative dimer interface [polypeptide binding]; other site 226900005560 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226900005561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 226900005562 GAF domain; Region: GAF; cl00853 226900005563 Histidine kinase; Region: HisKA_3; pfam07730 226900005564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900005565 ATP binding site [chemical binding]; other site 226900005566 Mg2+ binding site [ion binding]; other site 226900005567 G-X-G motif; other site 226900005568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900005569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900005570 active site 226900005571 phosphorylation site [posttranslational modification] 226900005572 intermolecular recognition site; other site 226900005573 dimerization interface [polypeptide binding]; other site 226900005574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900005575 DNA binding residues [nucleotide binding] 226900005576 dimerization interface [polypeptide binding]; other site 226900005577 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226900005578 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226900005579 putative active site [active] 226900005580 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 226900005581 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 226900005582 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 226900005583 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 226900005584 NAD binding site [chemical binding]; other site 226900005585 substrate binding site [chemical binding]; other site 226900005586 catalytic Zn binding site [ion binding]; other site 226900005587 tetramer interface [polypeptide binding]; other site 226900005588 structural Zn binding site [ion binding]; other site 226900005589 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900005590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900005591 dimer interface [polypeptide binding]; other site 226900005592 conserved gate region; other site 226900005593 ABC-ATPase subunit interface; other site 226900005594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900005595 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 226900005596 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 226900005597 N- and C-terminal domain interface [polypeptide binding]; other site 226900005598 putative active site [active] 226900005599 catalytic site [active] 226900005600 metal binding site [ion binding]; metal-binding site 226900005601 carbohydrate binding site [chemical binding]; other site 226900005602 ATP binding site [chemical binding]; other site 226900005603 gluconate transporter; Region: gntP; TIGR00791 226900005604 GntP family permease; Region: GntP_permease; cl15264 226900005605 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 226900005606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005607 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 226900005608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900005609 active site 226900005610 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900005611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005612 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900005613 putative substrate translocation pore; other site 226900005614 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900005615 putative active site [active] 226900005616 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 226900005617 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 226900005618 Walker A/P-loop; other site 226900005619 ATP binding site [chemical binding]; other site 226900005620 Q-loop/lid; other site 226900005621 ABC transporter signature motif; other site 226900005622 Walker B; other site 226900005623 D-loop; other site 226900005624 H-loop/switch region; other site 226900005625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900005626 dimer interface [polypeptide binding]; other site 226900005627 conserved gate region; other site 226900005628 ABC-ATPase subunit interface; other site 226900005629 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900005630 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 226900005631 Amino acid permease; Region: AA_permease; cl00524 226900005632 similar to 5-methylcytosine-specific restriction related enzyme 226900005633 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 226900005634 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900005635 Hemagglutinin; Region: Hemagglutinin; pfam00509 226900005636 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900005637 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900005638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900005639 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 226900005640 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900005641 NAD(P) binding site [chemical binding]; other site 226900005642 catalytic residues [active] 226900005643 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 226900005644 similar to Sporulation kinase; EC_number 2.7.3.- 226900005645 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 226900005646 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 226900005647 hypothetical protein; Provisional; Region: PRK06917 226900005648 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900005649 inhibitor-cofactor binding pocket; inhibition site 226900005650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005651 catalytic residue [active] 226900005652 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900005653 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900005654 acetylornithine deacetylase; Validated; Region: PRK06915 226900005655 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 226900005656 metal binding site [ion binding]; metal-binding site 226900005657 dimer interface [polypeptide binding]; other site 226900005658 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 226900005659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005660 Coenzyme A binding pocket [chemical binding]; other site 226900005661 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 226900005662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900005663 Walker A motif; other site 226900005664 ATP binding site [chemical binding]; other site 226900005665 Walker B motif; other site 226900005666 arginine finger; other site 226900005667 Helix-turn-helix domains; Region: HTH; cl00088 226900005668 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 226900005669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900005670 FeS/SAM binding site; other site 226900005671 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 226900005672 uncharacterized protein, YokU family; Region: YokU_near_AblA; TIGR03829 226900005673 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 226900005674 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 226900005675 YozD-like protein; Region: YozD; pfam14162 226900005676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226900005677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226900005678 active site 226900005679 ATP binding site [chemical binding]; other site 226900005680 substrate binding site [chemical binding]; other site 226900005681 activation loop (A-loop); other site 226900005682 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 226900005683 SpoOM protein; Region: Spo0M; pfam07070 226900005684 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226900005685 active site 226900005686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226900005687 Cation efflux family; Region: Cation_efflux; cl00316 226900005688 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900005689 catalytic residues [active] 226900005690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900005691 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005692 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 226900005693 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 226900005694 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900005695 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900005696 active site 226900005697 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 226900005698 PPIC-type PPIASE domain; Region: Rotamase; cl08278 226900005699 YolD-like protein; Region: YolD; pfam08863 226900005700 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900005701 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 226900005702 classical (c) SDRs; Region: SDR_c; cd05233 226900005703 NAD(P) binding site [chemical binding]; other site 226900005704 active site 226900005705 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 226900005706 Transglycosylase; Region: Transgly; cl07896 226900005707 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900005708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900005711 putative substrate translocation pore; other site 226900005712 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226900005713 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 226900005714 dimer interface [polypeptide binding]; other site 226900005715 Citrate synthase; Region: Citrate_synt; pfam00285 226900005716 active site 226900005717 coenzyme A binding site [chemical binding]; other site 226900005718 citrylCoA binding site [chemical binding]; other site 226900005719 oxalacetate/citrate binding site [chemical binding]; other site 226900005720 catalytic triad [active] 226900005721 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 226900005722 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 226900005723 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 226900005724 tetramer interface [polypeptide binding]; other site 226900005725 active site 226900005726 Mg2+/Mn2+ binding site [ion binding]; other site 226900005727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 226900005728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900005729 active site 226900005730 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 226900005731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005732 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 226900005733 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900005734 tetrameric interface [polypeptide binding]; other site 226900005735 NAD binding site [chemical binding]; other site 226900005736 catalytic residues [active] 226900005737 LysE type translocator; Region: LysE; cl00565 226900005738 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 226900005739 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900005740 substrate binding site [chemical binding]; other site 226900005741 oxyanion hole (OAH) forming residues; other site 226900005742 trimer interface [polypeptide binding]; other site 226900005743 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 226900005744 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 226900005745 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900005746 active site 226900005747 metal binding site [ion binding]; metal-binding site 226900005748 DNA binding site [nucleotide binding] 226900005749 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 226900005750 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 226900005751 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 226900005752 Walker A/P-loop; other site 226900005753 ATP binding site [chemical binding]; other site 226900005754 Q-loop/lid; other site 226900005755 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 226900005756 ABC transporter signature motif; other site 226900005757 Walker B; other site 226900005758 D-loop; other site 226900005759 H-loop/switch region; other site 226900005760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900005761 dimerization interface [polypeptide binding]; other site 226900005762 putative DNA binding site [nucleotide binding]; other site 226900005763 putative Zn2+ binding site [ion binding]; other site 226900005764 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 226900005765 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 226900005766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 226900005767 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900005768 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 226900005769 putative NAD(P) binding site [chemical binding]; other site 226900005770 active site 226900005771 isochorismate synthase DhbC; Validated; Region: PRK06923 226900005772 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226900005773 chorismate binding enzyme; Region: Chorismate_bind; cl10555 226900005774 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 226900005775 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900005776 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 226900005777 hydrophobic substrate binding pocket; other site 226900005778 Isochorismatase family; Region: Isochorismatase; pfam00857 226900005779 active site 226900005780 conserved cis-peptide bond; other site 226900005781 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900005782 peptide synthase; Provisional; Region: PRK12467 226900005783 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900005784 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900005785 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900005786 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900005787 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900005788 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 226900005789 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 226900005790 MbtH-like protein; Region: MbtH; cl01279 226900005791 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900005792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005793 putative substrate translocation pore; other site 226900005794 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 226900005795 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 226900005796 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 226900005797 IHF dimer interface [polypeptide binding]; other site 226900005798 IHF - DNA interface [nucleotide binding]; other site 226900005799 amidase; Validated; Region: PRK06565 226900005800 DinB superfamily; Region: DinB_2; cl00986 226900005801 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900005802 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 226900005803 active site 226900005804 catalytic triad [active] 226900005805 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900005806 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900005807 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900005808 RNA binding surface [nucleotide binding]; other site 226900005809 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 226900005810 probable active site [active] 226900005811 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 226900005812 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226900005813 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900005814 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226900005815 active site 226900005816 dimer interface [polypeptide binding]; other site 226900005817 motif 1; other site 226900005818 motif 2; other site 226900005819 motif 3; other site 226900005820 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226900005821 anticodon binding site; other site 226900005822 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900005823 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900005824 Walker A/P-loop; other site 226900005825 ATP binding site [chemical binding]; other site 226900005826 Q-loop/lid; other site 226900005827 ABC transporter signature motif; other site 226900005828 Walker B; other site 226900005829 D-loop; other site 226900005830 H-loop/switch region; other site 226900005831 FtsX-like permease family; Region: FtsX; pfam02687 226900005832 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900005833 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900005834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900005835 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900005836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900005837 pyruvate oxidase; Provisional; Region: PRK08611 226900005838 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 226900005839 PYR/PP interface [polypeptide binding]; other site 226900005840 tetramer interface [polypeptide binding]; other site 226900005841 dimer interface [polypeptide binding]; other site 226900005842 TPP binding site [chemical binding]; other site 226900005843 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 226900005844 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 226900005845 TPP-binding site [chemical binding]; other site 226900005846 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 226900005847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900005848 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 226900005849 active site 226900005850 dimerization interface [polypeptide binding]; other site 226900005851 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 226900005852 Protein of unknown function, DUF606; Region: DUF606; cl01273 226900005853 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900005854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900005855 ligand binding site [chemical binding]; other site 226900005856 flexible hinge region; other site 226900005857 Protein of unknown function, DUF606; Region: DUF606; cl01273 226900005858 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 226900005859 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900005861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900005862 Helix-turn-helix domains; Region: HTH; cl00088 226900005863 similar to Transporter, MMPL family 226900005864 putative transposase OrfB; Reviewed; Region: PHA02517 226900005865 Integrase core domain; Region: rve; cl01316 226900005866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900005867 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 226900005868 Transposase IS200 like; Region: Y1_Tnp; cl00848 226900005869 Probable transposase; Region: OrfB_IS605; pfam01385 226900005870 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900005871 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900005872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005873 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005874 Coenzyme A binding pocket [chemical binding]; other site 226900005875 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005877 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 226900005878 Coenzyme A binding pocket [chemical binding]; other site 226900005879 putative acetyltransferase YhhY; Provisional; Region: PRK10140 226900005880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005881 Coenzyme A binding pocket [chemical binding]; other site 226900005882 EamA-like transporter family; Region: EamA; cl01037 226900005883 EamA-like transporter family; Region: EamA; cl01037 226900005884 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900005885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005886 non-specific DNA binding site [nucleotide binding]; other site 226900005887 salt bridge; other site 226900005888 sequence-specific DNA binding site [nucleotide binding]; other site 226900005889 Cupin domain; Region: Cupin_2; cl09118 226900005890 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900005891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005892 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 226900005893 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900005894 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005895 Cold-inducible protein YdjO; Region: YdjO; pfam14169 226900005896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900005897 DNA-binding site [nucleotide binding]; DNA binding site 226900005898 RNA-binding motif; other site 226900005899 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900005900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005901 active site 226900005902 hypothetical protein; Provisional; Region: PRK06770 226900005903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900005904 Helix-turn-helix domains; Region: HTH; cl00088 226900005905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900005906 dimerization interface [polypeptide binding]; other site 226900005907 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 226900005908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005909 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 226900005910 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 226900005911 active site 226900005912 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 226900005913 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 226900005914 Helix-turn-helix domains; Region: HTH; cl00088 226900005915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900005916 dimerization interface [polypeptide binding]; other site 226900005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 226900005918 MOSC domain; Region: MOSC; pfam03473 226900005919 3-alpha domain; Region: 3-alpha; pfam03475 226900005920 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 226900005921 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900005922 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 226900005923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900005924 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900005925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900005926 Walker A/P-loop; other site 226900005927 ATP binding site [chemical binding]; other site 226900005928 Q-loop/lid; other site 226900005929 ABC transporter signature motif; other site 226900005930 Walker B; other site 226900005931 D-loop; other site 226900005932 H-loop/switch region; other site 226900005933 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900005934 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900005935 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 226900005936 Walker A/P-loop; other site 226900005937 ATP binding site [chemical binding]; other site 226900005938 Q-loop/lid; other site 226900005939 ABC transporter signature motif; other site 226900005940 Walker B; other site 226900005941 D-loop; other site 226900005942 H-loop/switch region; other site 226900005943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900005944 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 226900005945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900005946 LysE type translocator; Region: LysE; cl00565 226900005947 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900005948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005949 non-specific DNA binding site [nucleotide binding]; other site 226900005950 salt bridge; other site 226900005951 sequence-specific DNA binding site [nucleotide binding]; other site 226900005952 Cupin domain; Region: Cupin_2; cl09118 226900005953 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 226900005954 BclB C-terminal domain; Region: exospore_TM; TIGR03721 226900005955 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 226900005956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005958 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 226900005959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900005960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 226900005961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900005962 S-adenosylmethionine binding site [chemical binding]; other site 226900005963 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 226900005964 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 226900005965 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 226900005966 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900005967 active site 226900005968 P-loop; other site 226900005969 phosphorylation site [posttranslational modification] 226900005970 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900005971 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 226900005972 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 226900005973 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 226900005974 Domain of unknown function (DUF205); Region: DUF205; cl00410 226900005975 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 226900005976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900005977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900005978 catalytic residue [active] 226900005979 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 226900005980 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 226900005981 tetramer interface [polypeptide binding]; other site 226900005982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005983 catalytic residue [active] 226900005984 Helix-turn-helix domains; Region: HTH; cl00088 226900005985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900005987 putative substrate translocation pore; other site 226900005988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900005989 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 226900005990 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900005991 ATP binding site [chemical binding]; other site 226900005992 Mg++ binding site [ion binding]; other site 226900005993 motif III; other site 226900005994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900005995 nucleotide binding region [chemical binding]; other site 226900005996 ATP-binding site [chemical binding]; other site 226900005997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900005998 Helix-turn-helix domains; Region: HTH; cl00088 226900005999 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 226900006001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900006002 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226900006003 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 226900006004 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900006005 Phage integrase family; Region: Phage_integrase; pfam00589 226900006006 Int/Topo IB signature motif; other site 226900006007 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 226900006008 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 226900006009 sugar binding site [chemical binding]; other site 226900006010 Phage tail protein; Region: Sipho_tail; cl11462 226900006011 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 226900006012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006013 S-adenosylmethionine binding site [chemical binding]; other site 226900006014 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900006015 dimer interface [polypeptide binding]; other site 226900006016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900006017 cell division protein FtsZ; Region: ftsZ; TIGR00065 226900006018 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 226900006019 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 226900006020 dimer interface [polypeptide binding]; other site 226900006021 PYR/PP interface [polypeptide binding]; other site 226900006022 TPP binding site [chemical binding]; other site 226900006023 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 226900006024 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 226900006025 TPP-binding site [chemical binding]; other site 226900006026 dimer interface [polypeptide binding]; other site 226900006027 Helix-turn-helix domains; Region: HTH; cl00088 226900006028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900006029 catalytic core [active] 226900006030 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900006031 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 226900006032 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900006033 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 226900006034 metal binding site [ion binding]; metal-binding site 226900006035 dimer interface [polypeptide binding]; other site 226900006036 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 226900006037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900006038 DNA binding residues [nucleotide binding] 226900006039 dimerization interface [polypeptide binding]; other site 226900006040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006041 non-specific DNA binding site [nucleotide binding]; other site 226900006042 salt bridge; other site 226900006043 sequence-specific DNA binding site [nucleotide binding]; other site 226900006044 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 226900006045 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900006046 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900006047 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900006048 trimer interface [polypeptide binding]; other site 226900006049 active site 226900006050 substrate binding site [chemical binding]; other site 226900006051 CoA binding site [chemical binding]; other site 226900006052 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900006053 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900006054 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 226900006055 active site 226900006056 catalytic triad [active] 226900006057 oxyanion hole [active] 226900006058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006059 putative substrate translocation pore; other site 226900006060 Condensation domain; Region: Condensation; pfam00668 226900006061 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006062 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900006063 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006064 Condensation domain; Region: Condensation; pfam00668 226900006065 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 226900006066 peptide synthase; Provisional; Region: PRK12467 226900006067 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006068 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006069 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006070 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006071 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006072 peptide synthase; Validated; Region: PRK05691 226900006073 peptide synthase; Provisional; Region: PRK12467 226900006074 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006075 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006076 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900006077 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006078 peptide synthase; Provisional; Region: PRK12316 226900006079 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006080 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006081 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 226900006082 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006083 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900006084 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 226900006085 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 226900006086 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 226900006087 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 226900006088 Erythromycin esterase; Region: Erythro_esteras; pfam05139 226900006089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 226900006090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226900006091 catalytic residue [active] 226900006092 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006093 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006094 S-layer homology domain; Region: SLH; pfam00395 226900006095 S-layer homology domain; Region: SLH; pfam00395 226900006096 S-layer homology domain; Region: SLH; pfam00395 226900006097 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 226900006098 Collagenase; Region: Peptidase_M9; pfam01752 226900006099 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900006100 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900006101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006102 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 226900006103 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900006104 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900006105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006106 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226900006107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900006108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900006109 DNA binding residues [nucleotide binding] 226900006110 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900006111 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900006112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006113 similar to Penicillin-binding protein transpeptidase 226900006114 beta-lactamase TEM; Provisional; Region: PRK15442 226900006115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006117 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006118 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900006119 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900006120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900006121 putative active site [active] 226900006122 putative metal binding site [ion binding]; other site 226900006123 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900006124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006125 Walker A/P-loop; other site 226900006126 ATP binding site [chemical binding]; other site 226900006127 Q-loop/lid; other site 226900006128 ABC transporter signature motif; other site 226900006129 Walker B; other site 226900006130 D-loop; other site 226900006131 H-loop/switch region; other site 226900006132 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900006133 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900006134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900006135 Helix-turn-helix domains; Region: HTH; cl00088 226900006136 Protein of unknown function (DUF523); Region: DUF523; cl00733 226900006137 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 226900006138 similar to Acyl-CoA dehydrogenase, short-chain specific; EC_number 1.3.99.2 226900006139 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 226900006140 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900006141 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900006142 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 226900006143 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900006144 carboxyltransferase (CT) interaction site; other site 226900006145 biotinylation site [posttranslational modification]; other site 226900006146 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 226900006147 active site 226900006148 catalytic residues [active] 226900006149 metal binding site [ion binding]; metal-binding site 226900006150 enoyl-CoA hydratase; Provisional; Region: PRK07657 226900006151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900006152 substrate binding site [chemical binding]; other site 226900006153 oxyanion hole (OAH) forming residues; other site 226900006154 trimer interface [polypeptide binding]; other site 226900006155 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 226900006156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 226900006157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 226900006158 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 226900006159 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 226900006160 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900006161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900006162 putative transposase OrfB; Reviewed; Region: PHA02517 226900006163 Integrase core domain; Region: rve; cl01316 226900006164 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006165 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900006167 dimer interface [polypeptide binding]; other site 226900006168 phosphorylation site [posttranslational modification] 226900006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006170 ATP binding site [chemical binding]; other site 226900006171 Mg2+ binding site [ion binding]; other site 226900006172 G-X-G motif; other site 226900006173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900006174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900006175 active site 226900006176 phosphorylation site [posttranslational modification] 226900006177 intermolecular recognition site; other site 226900006178 dimerization interface [polypeptide binding]; other site 226900006179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900006180 DNA binding site [nucleotide binding] 226900006181 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 226900006182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900006183 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 226900006184 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 226900006185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006186 Coenzyme A binding pocket [chemical binding]; other site 226900006187 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006188 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900006189 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900006190 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900006191 active site 226900006192 Zn binding site [ion binding]; other site 226900006193 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226900006194 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226900006195 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226900006196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900006197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900006198 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006199 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006200 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006201 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 226900006202 active site 226900006203 catalytic site [active] 226900006204 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900006205 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006206 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006207 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006208 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900006209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900006210 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 226900006211 putative hydrophobic ligand binding site [chemical binding]; other site 226900006212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006213 Walker A/P-loop; other site 226900006214 ATP binding site [chemical binding]; other site 226900006215 The excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent...; Region: ABC_UvrA; cd03238 226900006216 The excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent...; Region: ABC_UvrA; cd03238 226900006217 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 226900006218 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 226900006219 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900006220 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226900006221 DNA binding residues [nucleotide binding] 226900006222 drug binding residues [chemical binding]; other site 226900006223 dimer interface [polypeptide binding]; other site 226900006224 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900006225 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006227 putative substrate translocation pore; other site 226900006228 classical (c) SDRs; Region: SDR_c; cd05233 226900006229 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226900006230 NAD(P) binding site [chemical binding]; other site 226900006231 active site 226900006232 Helix-turn-helix domains; Region: HTH; cl00088 226900006233 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900006235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900006236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900006237 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900006238 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900006239 metal binding site [ion binding]; metal-binding site 226900006240 Phosphotransferase enzyme family; Region: APH; pfam01636 226900006241 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 226900006242 active site 226900006243 substrate binding site [chemical binding]; other site 226900006244 ATP binding site [chemical binding]; other site 226900006245 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 226900006246 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 226900006247 active site 226900006248 Zn binding site [ion binding]; other site 226900006249 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 226900006250 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006252 DNA-binding site [nucleotide binding]; DNA binding site 226900006253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006255 homodimer interface [polypeptide binding]; other site 226900006256 catalytic residue [active] 226900006257 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900006258 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900006259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 226900006260 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 226900006261 putative NAD(P) binding site [chemical binding]; other site 226900006262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900006263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006264 NAD(P) binding site [chemical binding]; other site 226900006265 active site 226900006266 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900006267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006268 S-adenosylmethionine binding site [chemical binding]; other site 226900006269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006270 S-adenosylmethionine binding site [chemical binding]; other site 226900006271 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 226900006272 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 226900006273 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 226900006274 active site 226900006275 HIGH motif; other site 226900006276 KMSKS motif; other site 226900006277 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900006278 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 226900006279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900006280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900006281 active site 226900006282 phosphorylation site [posttranslational modification] 226900006283 intermolecular recognition site; other site 226900006284 dimerization interface [polypeptide binding]; other site 226900006285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900006286 DNA binding site [nucleotide binding] 226900006287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900006288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 226900006289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006290 ATP binding site [chemical binding]; other site 226900006291 Mg2+ binding site [ion binding]; other site 226900006292 G-X-G motif; other site 226900006293 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 226900006294 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900006295 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900006296 ABC transporter; Region: ABC_tran_2; pfam12848 226900006297 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900006298 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006299 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900006300 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900006301 Walker A/P-loop; other site 226900006302 ATP binding site [chemical binding]; other site 226900006303 Q-loop/lid; other site 226900006304 ABC transporter signature motif; other site 226900006305 Walker B; other site 226900006306 D-loop; other site 226900006307 H-loop/switch region; other site 226900006308 FtsX-like permease family; Region: FtsX; pfam02687 226900006309 hypothetical protein; Provisional; Region: PRK06760; cl11698 226900006310 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 226900006311 similar to Lipase; EC_number 3.1.1.3 226900006312 homoserine dehydrogenase; Validated; Region: PRK06813 226900006313 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900006314 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006316 DNA-binding site [nucleotide binding]; DNA binding site 226900006317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006319 homodimer interface [polypeptide binding]; other site 226900006320 catalytic residue [active] 226900006321 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 226900006322 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226900006323 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900006324 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 226900006325 Bacteriophage phBC6A52; identified by comparison with Bacillus anthracis 226900006326 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 226900006327 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 226900006328 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 226900006329 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900006330 Phage integrase family; Region: Phage_integrase; pfam00589 226900006331 Int/Topo IB signature motif; other site 226900006332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006333 non-specific DNA binding site [nucleotide binding]; other site 226900006334 salt bridge; other site 226900006335 sequence-specific DNA binding site [nucleotide binding]; other site 226900006336 Helix-turn-helix domains; Region: HTH; cl00088 226900006337 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900006338 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900006339 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 226900006340 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 226900006341 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226900006342 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900006343 Phage integrase family; Region: Phage_integrase; pfam00589 226900006344 Int/Topo IB signature motif; other site 226900006345 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 226900006346 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 226900006347 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 226900006348 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 226900006349 Phage Terminase; Region: Terminase_1; pfam03354 226900006350 Phage portal protein; Region: Phage_portal; pfam04860 226900006351 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 226900006352 Phage capsid family; Region: Phage_capsid; pfam05065 226900006353 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 226900006354 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 226900006355 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 226900006356 Phage-related minor tail protein [Function unknown]; Region: COG5280 226900006357 membrane protein P6; Region: PHA01399 226900006358 Phage-related protein [Function unknown]; Region: COG5412 226900006359 Phage tail protein; Region: Sipho_tail; cl11462 226900006360 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 226900006361 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 226900006362 Holin family; Region: Phage_holin_4; cl01989 226900006363 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900006364 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900006365 active site 226900006366 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900006367 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 226900006368 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 226900006369 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 226900006370 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 226900006371 Protein of unknown function; Region: DUF3658; pfam12395 226900006372 Cytochrome P450; Region: p450; cl12078 226900006373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006374 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006376 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900006377 trimer interface [polypeptide binding]; other site 226900006378 active site 226900006379 substrate binding site [chemical binding]; other site 226900006380 CoA binding site [chemical binding]; other site 226900006381 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 226900006382 Cytochrome P450; Region: p450; cl12078 226900006383 Transposase IS200 like; Region: Y1_Tnp; cl00848 226900006384 Probable transposase; Region: OrfB_IS605; pfam01385 226900006385 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900006386 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900006387 Cytochrome P450; Region: p450; cl12078 226900006388 Cupin domain; Region: Cupin_2; cl09118 226900006389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900006390 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900006391 active site 226900006392 motif I; other site 226900006393 motif II; other site 226900006394 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900006395 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900006396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900006397 dimer interface [polypeptide binding]; other site 226900006398 phosphorylation site [posttranslational modification] 226900006399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006400 ATP binding site [chemical binding]; other site 226900006401 Mg2+ binding site [ion binding]; other site 226900006402 G-X-G motif; other site 226900006403 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900006404 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900006405 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900006406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006407 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900006408 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900006409 Catalytic site [active] 226900006410 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 226900006411 homodimer interface [polypeptide binding]; other site 226900006412 active site 226900006413 TDP-binding site; other site 226900006414 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900006415 aspartate racemase; Region: asp_race; TIGR00035 226900006416 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900006417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900006418 Phage integrase family; Region: Phage_integrase; pfam00589 226900006419 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900006420 DNA binding site [nucleotide binding] 226900006421 Int/Topo IB signature motif; other site 226900006422 active site 226900006423 catalytic residues [active] 226900006424 Phage integrase family; Region: Phage_integrase; pfam00589 226900006425 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900006426 DNA binding site [nucleotide binding] 226900006427 Int/Topo IB signature motif; other site 226900006428 active site 226900006429 catalytic residues [active] 226900006430 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900006431 DNA binding site [nucleotide binding] 226900006432 Int/Topo IB signature motif; other site 226900006433 active site 226900006434 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 226900006435 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 226900006436 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 226900006437 substrate binding site [chemical binding]; other site 226900006438 active site 226900006439 cosubstrate binding site; other site 226900006440 catalytic site [active] 226900006441 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 226900006442 hypothetical protein; Validated; Region: PRK08223 226900006443 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 226900006444 ATP binding site [chemical binding]; other site 226900006445 substrate interface [chemical binding]; other site 226900006446 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900006447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900006448 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900006449 Cytochrome P450; Region: p450; cl12078 226900006450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006451 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900006452 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006453 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006454 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006455 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006456 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006457 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006458 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006459 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006460 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006461 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006462 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006463 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006464 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006465 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006466 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006467 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006468 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006469 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006470 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006471 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006472 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006473 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006474 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006475 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006476 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006477 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006478 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006479 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006480 Domain of unknown function DUF11; Region: DUF11; cl15273 226900006481 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 226900006482 catalytic triad [active] 226900006483 conserved cis-peptide bond; other site 226900006484 similar to Transposase 226900006485 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226900006486 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900006487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900006488 motif II; other site 226900006489 DinB superfamily; Region: DinB_2; cl00986 226900006490 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006491 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226900006492 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226900006493 putative active site [active] 226900006494 putative NTP binding site [chemical binding]; other site 226900006495 putative nucleic acid binding site [nucleotide binding]; other site 226900006496 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226900006497 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 226900006498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006499 non-specific DNA binding site [nucleotide binding]; other site 226900006500 salt bridge; other site 226900006501 sequence-specific DNA binding site [nucleotide binding]; other site 226900006502 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 226900006503 Endoplasmic Reticulum Oxidoreductin 1 (ERO1); Region: ERO1; pfam04137 226900006504 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900006505 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 226900006506 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 226900006507 Walker A/P-loop; other site 226900006508 ATP binding site [chemical binding]; other site 226900006509 Q-loop/lid; other site 226900006510 ABC transporter signature motif; other site 226900006511 Walker B; other site 226900006512 D-loop; other site 226900006513 H-loop/switch region; other site 226900006514 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 226900006515 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 226900006516 Walker A/P-loop; other site 226900006517 ATP binding site [chemical binding]; other site 226900006518 Q-loop/lid; other site 226900006519 ABC transporter signature motif; other site 226900006520 Walker B; other site 226900006521 D-loop; other site 226900006522 H-loop/switch region; other site 226900006523 Cobalt transport protein; Region: CbiQ; cl00463 226900006524 similar to Sporulation kinase; EC_number 2.7.3.- 226900006525 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 226900006526 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900006527 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 226900006528 NAD(P) binding site [chemical binding]; other site 226900006529 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 226900006530 active site 226900006531 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 226900006532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900006533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006534 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 226900006535 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226900006536 similar to Lysine-specific permease 226900006537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006538 VanZ like family; Region: VanZ; cl01971 226900006539 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 226900006540 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 226900006541 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226900006542 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900006543 Helix-turn-helix domains; Region: HTH; cl00088 226900006544 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 226900006545 conserved cys residue [active] 226900006546 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900006547 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 226900006548 DNA binding residues [nucleotide binding] 226900006549 putative dimer interface [polypeptide binding]; other site 226900006550 Trm112p-like protein; Region: Trm112p; cl01066 226900006551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900006552 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006555 Coenzyme A binding pocket [chemical binding]; other site 226900006556 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 226900006557 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 226900006558 active site 226900006559 catalytic site [active] 226900006560 metal binding site [ion binding]; metal-binding site 226900006561 Bacterial SH3 domain; Region: SH3_3; cl02551 226900006562 Bacterial SH3 domain; Region: SH3_3; cl02551 226900006563 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 226900006564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006566 DNA-binding site [nucleotide binding]; DNA binding site 226900006567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006569 homodimer interface [polypeptide binding]; other site 226900006570 catalytic residue [active] 226900006571 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900006572 EamA-like transporter family; Region: EamA; cl01037 226900006573 EamA-like transporter family; Region: EamA; cl01037 226900006574 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 226900006575 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900006576 active site 226900006577 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006578 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900006579 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 226900006580 nudix motif; other site 226900006581 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 226900006582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006583 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 226900006584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 226900006585 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 226900006586 Cadmium resistance transporter; Region: Cad; cl04177 226900006587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006588 Coenzyme A binding pocket [chemical binding]; other site 226900006589 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900006590 nudix motif; other site 226900006591 DNA polymerase III subunit beta; Validated; Region: PRK06673 226900006592 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226900006593 putative DNA binding surface [nucleotide binding]; other site 226900006594 dimer interface [polypeptide binding]; other site 226900006595 beta-clamp/clamp loader binding surface; other site 226900006596 beta-clamp/translesion DNA polymerase binding surface; other site 226900006597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900006598 translation initiation factor IF-2; Provisional; Region: PRK14845 226900006599 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226900006600 homotrimer interaction site [polypeptide binding]; other site 226900006601 putative active site [active] 226900006602 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 226900006603 similar to Esterase 226900006604 YxiJ-like protein; Region: YxiJ; pfam14176 226900006605 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 226900006606 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 226900006607 active site 226900006608 nucleophile elbow; other site 226900006609 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 226900006610 DinB superfamily; Region: DinB_2; cl00986 226900006611 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006612 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 226900006613 Bacitracin resistance protein BacA; Region: BacA; cl00858 226900006614 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 226900006615 GIY-YIG motif/motif A; other site 226900006616 active site 226900006617 catalytic site [active] 226900006618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006619 Coenzyme A binding pocket [chemical binding]; other site 226900006620 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 226900006621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900006622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006623 Walker A/P-loop; other site 226900006624 ATP binding site [chemical binding]; other site 226900006625 Q-loop/lid; other site 226900006626 ABC transporter signature motif; other site 226900006627 Walker B; other site 226900006628 D-loop; other site 226900006629 H-loop/switch region; other site 226900006630 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900006631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226900006632 active site 226900006633 ATP binding site [chemical binding]; other site 226900006634 substrate binding site [chemical binding]; other site 226900006635 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 226900006636 nudix motif; other site 226900006637 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900006638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006640 Protein of unknown function (DUF419); Region: DUF419; cl15265 226900006641 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900006642 MepB protein; Region: MepB; cl01985 226900006643 MepB protein; Region: MepB; cl01985 226900006644 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 226900006645 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900006647 motif II; other site 226900006648 DinB superfamily; Region: DinB_2; cl00986 226900006649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900006650 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 226900006651 carbohydrate binding site [chemical binding]; other site 226900006652 pullulanase, type I; Region: pulA_typeI; TIGR02104 226900006653 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 226900006654 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 226900006655 Ca binding site [ion binding]; other site 226900006656 active site 226900006657 catalytic site [active] 226900006658 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900006659 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900006660 active site 226900006661 Zn binding site [ion binding]; other site 226900006662 similar to CLV1 receptor kinase 226900006663 DinB superfamily; Region: DinB_2; cl00986 226900006664 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900006665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 226900006666 putative metal binding site [ion binding]; other site 226900006667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900006668 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 226900006669 SecY translocase; Region: SecY; pfam00344 226900006670 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 226900006671 EamA-like transporter family; Region: EamA; cl01037 226900006672 EamA-like transporter family; Region: EamA; cl01037 226900006673 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006675 DNA-binding site [nucleotide binding]; DNA binding site 226900006676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006678 homodimer interface [polypeptide binding]; other site 226900006679 catalytic residue [active] 226900006680 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900006681 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900006682 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 226900006683 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 226900006684 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006685 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 226900006686 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900006687 germination protein YpeB; Region: spore_YpeB; TIGR02889 226900006688 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 226900006689 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 226900006690 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 226900006691 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900006692 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 226900006693 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006694 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 226900006695 Putative cyclase; Region: Cyclase; cl00814 226900006696 kynureninase; Region: kynureninase; TIGR01814 226900006697 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900006698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900006699 catalytic residue [active] 226900006700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900006701 Helix-turn-helix domains; Region: HTH; cl00088 226900006702 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900006703 nudix motif; other site 226900006704 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900006705 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 226900006706 hydrophobic ligand binding site; other site 226900006707 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 226900006708 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 226900006709 GAF domain; Region: GAF; cl00853 226900006710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900006711 Walker A motif; other site 226900006712 ATP binding site [chemical binding]; other site 226900006713 Walker B motif; other site 226900006714 arginine finger; other site 226900006715 Helix-turn-helix domains; Region: HTH; cl00088 226900006716 NIPSNAP; Region: NIPSNAP; pfam07978 226900006717 putative acetyltransferase YhhY; Provisional; Region: PRK10140 226900006718 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006719 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900006720 Helix-turn-helix domains; Region: HTH; cl00088 226900006721 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006723 S-adenosylmethionine binding site [chemical binding]; other site 226900006724 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900006725 Helix-turn-helix domains; Region: HTH; cl00088 226900006726 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 226900006727 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 226900006728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 226900006731 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900006732 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900006733 E3 interaction surface; other site 226900006734 lipoyl attachment site [posttranslational modification]; other site 226900006735 e3 binding domain; Region: E3_binding; pfam02817 226900006736 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 226900006737 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900006738 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900006739 alpha subunit interface [polypeptide binding]; other site 226900006740 TPP binding site [chemical binding]; other site 226900006741 heterodimer interface [polypeptide binding]; other site 226900006742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900006743 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 226900006744 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900006745 tetramer interface [polypeptide binding]; other site 226900006746 TPP-binding site [chemical binding]; other site 226900006747 heterodimer interface [polypeptide binding]; other site 226900006748 phosphorylation loop region [posttranslational modification] 226900006749 DinB superfamily; Region: DinB_2; cl00986 226900006750 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 226900006751 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 226900006752 NADP binding site [chemical binding]; other site 226900006753 active site 226900006754 steroid binding site; other site 226900006755 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 226900006756 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 226900006757 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 226900006758 nudix motif; other site 226900006759 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 226900006760 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900006761 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 226900006762 nucleotide binding site/active site [active] 226900006763 HIT family signature motif; other site 226900006764 catalytic residue [active] 226900006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900006766 dimer interface [polypeptide binding]; other site 226900006767 conserved gate region; other site 226900006768 putative PBP binding loops; other site 226900006769 ABC-ATPase subunit interface; other site 226900006770 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 226900006771 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 226900006772 Walker A/P-loop; other site 226900006773 ATP binding site [chemical binding]; other site 226900006774 Q-loop/lid; other site 226900006775 ABC transporter signature motif; other site 226900006776 Walker B; other site 226900006777 D-loop; other site 226900006778 H-loop/switch region; other site 226900006779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 226900006780 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900006781 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 226900006782 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226900006783 oligomer interface [polypeptide binding]; other site 226900006784 active site residues [active] 226900006785 RNA polymerase factor sigma-70; Validated; Region: PRK06704 226900006786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900006787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 226900006788 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900006789 catalytic loop [active] 226900006790 iron binding site [ion binding]; other site 226900006791 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 226900006792 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900006793 active site 226900006794 dimer interface [polypeptide binding]; other site 226900006795 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006796 Chitin binding domain; Region: Chitin_bind_3; cl03871 226900006797 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900006798 Interdomain contacts; other site 226900006799 Cytokine receptor motif; other site 226900006800 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900006801 Interdomain contacts; other site 226900006802 Cytokine receptor motif; other site 226900006803 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 226900006804 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 226900006805 glycosyltransferase, MGT family; Region: MGT; TIGR01426 226900006806 active site 226900006807 TDP-binding site; other site 226900006808 acceptor substrate-binding pocket; other site 226900006809 homodimer interface [polypeptide binding]; other site 226900006810 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 226900006811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006812 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 226900006813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006814 S-adenosylmethionine binding site [chemical binding]; other site 226900006815 Protein of unknown function (DUF419); Region: DUF419; cl15265 226900006816 similar to Acetyltransferase; EC_number 2.3.1.- 226900006817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006818 Coenzyme A binding pocket [chemical binding]; other site 226900006819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900006820 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006822 Coenzyme A binding pocket [chemical binding]; other site 226900006823 Helix-turn-helix domains; Region: HTH; cl00088 226900006824 similar to ATP-dependent DNA helicase rep; EC_number 3.6.1.- 226900006825 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900006826 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 226900006827 putative active site pocket [active] 226900006828 dimerization interface [polypeptide binding]; other site 226900006829 putative catalytic residue [active] 226900006830 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 226900006831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900006832 ATP binding site [chemical binding]; other site 226900006833 putative Mg++ binding site [ion binding]; other site 226900006834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900006835 nucleotide binding region [chemical binding]; other site 226900006836 ATP-binding site [chemical binding]; other site 226900006837 RQC domain; Region: RQC; cl09632 226900006838 HRDC domain; Region: HRDC; cl02578 226900006839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900006840 Helix-turn-helix domains; Region: HTH; cl00088 226900006841 putative transposase OrfB; Reviewed; Region: PHA02517 226900006842 Integrase core domain; Region: rve; cl01316 226900006843 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900006844 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900006845 active site 226900006846 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900006847 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900006848 active site 226900006849 metal binding site [ion binding]; metal-binding site 226900006850 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900006851 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 226900006852 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 226900006853 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226900006854 DHHA2 domain; Region: DHHA2; pfam02833 226900006855 Chitin binding domain; Region: Chitin_bind_3; cl03871 226900006856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006857 Coenzyme A binding pocket [chemical binding]; other site 226900006858 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 226900006859 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 226900006860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900006861 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 226900006862 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900006863 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 226900006864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900006865 NAD(P) binding site [chemical binding]; other site 226900006866 catalytic residues [active] 226900006867 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 226900006868 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 226900006869 inhibitor site; inhibition site 226900006870 active site 226900006871 dimer interface [polypeptide binding]; other site 226900006872 catalytic residue [active] 226900006873 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 226900006874 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 226900006875 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 226900006876 Proline racemase; Region: Pro_racemase; pfam05544 226900006877 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900006878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006879 sensory histidine kinase AtoS; Provisional; Region: PRK11360 226900006880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900006881 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 226900006882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900006883 Walker A motif; other site 226900006884 ATP binding site [chemical binding]; other site 226900006885 Walker B motif; other site 226900006886 arginine finger; other site 226900006887 Helix-turn-helix domains; Region: HTH; cl00088 226900006888 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 226900006889 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900006890 catalytic loop [active] 226900006891 iron binding site [ion binding]; other site 226900006892 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900006893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006894 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 226900006895 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 226900006896 similar to Alkaline phosphatase like protein 226900006897 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 226900006898 DltD N-terminal region; Region: DltD_N; pfam04915 226900006899 DltD central region; Region: DltD_M; pfam04918 226900006900 DltD C-terminal region; Region: DltD_C; pfam04914 226900006901 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006902 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900006903 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900006904 peptide binding site [polypeptide binding]; other site 226900006905 NlpC/P60 family; Region: NLPC_P60; cl11438 226900006906 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226900006907 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 226900006908 active site 226900006909 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 226900006910 Septum formation initiator; Region: DivIC; cl11433 226900006911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900006912 active site 226900006913 catalytic tetrad [active] 226900006914 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 226900006915 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 226900006916 conserved cys residue [active] 226900006917 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900006918 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900006919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006920 AAA domain; Region: AAA_18; pfam13238 226900006921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006922 S-adenosylmethionine binding site [chemical binding]; other site 226900006923 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 226900006924 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 226900006925 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 226900006926 PPIC-type PPIASE domain; Region: Rotamase; cl08278 226900006927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900006928 dimerization interface [polypeptide binding]; other site 226900006929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900006930 dimer interface [polypeptide binding]; other site 226900006931 phosphorylation site [posttranslational modification] 226900006932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006933 ATP binding site [chemical binding]; other site 226900006934 Mg2+ binding site [ion binding]; other site 226900006935 G-X-G motif; other site 226900006936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900006937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900006938 active site 226900006939 phosphorylation site [posttranslational modification] 226900006940 intermolecular recognition site; other site 226900006941 dimerization interface [polypeptide binding]; other site 226900006942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900006943 DNA binding site [nucleotide binding] 226900006944 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900006945 similar to S-adenosylhomocysteine nucleotidase; EC_number 3.2.2.9 226900006946 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 226900006947 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900006948 Zn binding site [ion binding]; other site 226900006949 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 226900006950 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900006951 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900006952 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900006953 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006954 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900006955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006957 putative substrate translocation pore; other site 226900006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006959 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 226900006960 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 226900006961 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 226900006962 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 226900006963 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 226900006964 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 226900006965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006967 putative substrate translocation pore; other site 226900006968 large tegument protein UL36; Provisional; Region: PHA03246 226900006969 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900006970 active site 226900006971 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 226900006972 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900006973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006974 S-adenosylmethionine binding site [chemical binding]; other site 226900006975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006976 putative substrate translocation pore; other site 226900006977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006978 aspartate aminotransferase; Provisional; Region: PRK07681 226900006979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006981 homodimer interface [polypeptide binding]; other site 226900006982 catalytic residue [active] 226900006983 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226900006984 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 226900006985 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 226900006986 hypothetical protein; Provisional; Region: PRK13679 226900006987 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 226900006988 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 226900006989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900006990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900006991 Walker A/P-loop; other site 226900006992 ATP binding site [chemical binding]; other site 226900006993 Q-loop/lid; other site 226900006994 ABC transporter signature motif; other site 226900006995 Walker B; other site 226900006996 D-loop; other site 226900006997 H-loop/switch region; other site 226900006998 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900006999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900007000 DNA-binding site [nucleotide binding]; DNA binding site 226900007001 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900007002 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900007003 HNH endonuclease; Region: HNH_5; pfam14279 226900007004 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 226900007005 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 226900007006 active site 226900007007 dimer interface [polypeptide binding]; other site 226900007008 non-prolyl cis peptide bond; other site 226900007009 insertion regions; other site 226900007010 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900007011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900007012 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 226900007013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900007014 substrate binding pocket [chemical binding]; other site 226900007015 membrane-bound complex binding site; other site 226900007016 hinge residues; other site 226900007017 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900007018 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 226900007019 Walker A/P-loop; other site 226900007020 ATP binding site [chemical binding]; other site 226900007021 Q-loop/lid; other site 226900007022 ABC transporter signature motif; other site 226900007023 Walker B; other site 226900007024 D-loop; other site 226900007025 H-loop/switch region; other site 226900007026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007027 Helix-turn-helix domains; Region: HTH; cl00088 226900007028 Protein of unknown function (DUF402); Region: DUF402; cl00979 226900007029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 226900007030 binding surface 226900007031 TPR motif; other site 226900007032 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 226900007033 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 226900007034 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007035 EamA-like transporter family; Region: EamA; cl01037 226900007036 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007038 Coenzyme A binding pocket [chemical binding]; other site 226900007039 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007040 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007041 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226900007042 active site 226900007043 NTP binding site [chemical binding]; other site 226900007044 metal binding triad [ion binding]; metal-binding site 226900007045 antibiotic binding site [chemical binding]; other site 226900007046 A new structural DNA glycosylase; Region: AlkD_like; cd06561 226900007047 active site 226900007048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007049 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007050 active site 226900007051 metal binding site [ion binding]; metal-binding site 226900007052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900007053 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900007054 NodB motif; other site 226900007055 active site 226900007056 catalytic site [active] 226900007057 Zn binding site [ion binding]; other site 226900007058 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 226900007059 Integral membrane protein TerC family; Region: TerC; cl10468 226900007060 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900007061 Sulfatase; Region: Sulfatase; cl10460 226900007062 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 226900007063 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007064 Walker A/P-loop; other site 226900007065 ATP binding site [chemical binding]; other site 226900007066 Q-loop/lid; other site 226900007067 ABC transporter signature motif; other site 226900007068 Walker B; other site 226900007069 D-loop; other site 226900007070 H-loop/switch region; other site 226900007071 ABC transporter; Region: ABC_tran_2; pfam12848 226900007072 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900007073 hypothetical protein; Provisional; Region: PRK06761 226900007074 similar to Transporter, MMPL family 226900007075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007076 Helix-turn-helix domains; Region: HTH; cl00088 226900007077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007078 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 226900007079 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 226900007080 hinge; other site 226900007081 active site 226900007082 prephenate dehydrogenase; Validated; Region: PRK06545 226900007083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007084 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 226900007085 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 226900007086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007088 homodimer interface [polypeptide binding]; other site 226900007089 catalytic residue [active] 226900007090 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226900007091 Tetramer interface [polypeptide binding]; other site 226900007092 active site 226900007093 FMN-binding site [chemical binding]; other site 226900007094 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 226900007095 Chorismate mutase type II; Region: CM_2; cl00693 226900007096 NeuB family; Region: NeuB; cl00496 226900007097 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 226900007098 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 226900007099 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 226900007100 Isochorismatase family; Region: Isochorismatase; pfam00857 226900007101 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900007102 catalytic triad [active] 226900007103 conserved cis-peptide bond; other site 226900007104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007105 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007106 YfzA-like protein; Region: YfzA; pfam14118 226900007107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007108 Bacterial SH3 domain; Region: SH3_3; cl02551 226900007109 Bacterial SH3 domain; Region: SH3_3; cl02551 226900007110 3D domain; Region: 3D; cl01439 226900007111 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 226900007112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007113 putative metal binding site [ion binding]; other site 226900007114 Berberine and berberine like; Region: BBE; pfam08031 226900007115 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 226900007116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007117 Predicted dehydrogenase [General function prediction only]; Region: COG0579 226900007118 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 226900007119 ligand binding site [chemical binding]; other site 226900007120 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900007121 TM-ABC transporter signature motif; other site 226900007122 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900007123 TM-ABC transporter signature motif; other site 226900007124 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 226900007125 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 226900007126 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900007127 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900007128 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 226900007129 Autoinducer-2 kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 226900007130 putative N- and C-terminal domain interface [polypeptide binding]; other site 226900007131 putative active site [active] 226900007132 putative MgATP binding site [chemical binding]; other site 226900007133 catalytic site [active] 226900007134 metal binding site [ion binding]; metal-binding site 226900007135 putative carbohydrate binding site [chemical binding]; other site 226900007136 Cupin domain; Region: Cupin_2; cl09118 226900007137 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 226900007138 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 226900007139 putative active site; other site 226900007140 catalytic residue [active] 226900007141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007142 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007143 active site 226900007144 metal binding site [ion binding]; metal-binding site 226900007145 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007147 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900007148 putative substrate translocation pore; other site 226900007149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007150 putative DNA binding site [nucleotide binding]; other site 226900007151 putative Zn2+ binding site [ion binding]; other site 226900007152 DinB superfamily; Region: DinB_2; cl00986 226900007153 nucleoside transporter; Region: nupC; TIGR00804 226900007154 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900007155 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900007156 similar to Gamma-glutamyl phosphate reductase (GPR); EC_number 1.2.1.41 226900007157 gamma-glutamyl kinase; Provisional; Region: PRK05429 226900007158 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 226900007159 nucleotide binding site [chemical binding]; other site 226900007160 homotetrameric interface [polypeptide binding]; other site 226900007161 putative phosphate binding site [ion binding]; other site 226900007162 putative allosteric binding site; other site 226900007163 PUA domain; Region: PUA; cl00607 226900007164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007165 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 226900007166 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 226900007167 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 226900007168 putative metal binding site [ion binding]; other site 226900007169 putative dimer interface [polypeptide binding]; other site 226900007170 Helix-turn-helix domains; Region: HTH; cl00088 226900007171 Transcriptional regulator [Transcription]; Region: IclR; COG1414 226900007172 Bacterial transcriptional regulator; Region: IclR; pfam01614 226900007173 Amino acid permease; Region: AA_permease; cl00524 226900007174 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900007175 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 226900007176 putative metal binding site [ion binding]; other site 226900007177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007178 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 226900007179 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 226900007180 putative di-iron ligands [ion binding]; other site 226900007181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900007182 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 226900007183 VanW like protein; Region: VanW; pfam04294 226900007184 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 226900007185 dimer interface [polypeptide binding]; other site 226900007186 Alkaline phosphatase homologues; Region: alkPPc; smart00098 226900007187 active site 226900007188 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 226900007189 Helix-turn-helix domains; Region: HTH; cl00088 226900007190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900007191 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 226900007192 active site 226900007193 motif I; other site 226900007194 motif II; other site 226900007195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007196 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007197 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007199 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007200 active site 226900007201 metal binding site [ion binding]; metal-binding site 226900007202 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 226900007203 Helix-turn-helix domains; Region: HTH; cl00088 226900007204 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900007205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900007206 Walker A motif; other site 226900007207 ATP binding site [chemical binding]; other site 226900007208 Walker B motif; other site 226900007209 arginine finger; other site 226900007210 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226900007211 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226900007212 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 226900007213 proline/glycine betaine transporter; Provisional; Region: PRK10642 226900007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007215 putative substrate translocation pore; other site 226900007216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007218 active site 226900007219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007220 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226900007221 Ligand binding site; other site 226900007222 Putative Catalytic site; other site 226900007223 DXD motif; other site 226900007224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007226 active site 226900007227 acetylornithine aminotransferase; Provisional; Region: PRK02627 226900007228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900007229 inhibitor-cofactor binding pocket; inhibition site 226900007230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007231 catalytic residue [active] 226900007232 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 226900007233 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900007234 tetramer interface [polypeptide binding]; other site 226900007235 heme binding pocket [chemical binding]; other site 226900007236 Collagenase; Region: Peptidase_M9; pfam01752 226900007237 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900007238 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900007239 Collagenase; Region: Peptidase_M9; pfam01752 226900007240 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 226900007241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226900007242 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 226900007243 active site 226900007244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226900007245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007246 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 226900007247 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226900007248 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226900007249 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900007250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007251 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 226900007252 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 226900007253 Bacillus transposase protein; Region: Transposase_30; pfam04740 226900007254 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900007255 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900007256 dimer interface [polypeptide binding]; other site 226900007257 FMN binding site [chemical binding]; other site 226900007258 Helix-turn-helix domains; Region: HTH; cl00088 226900007259 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 226900007260 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 226900007261 G1 box; other site 226900007262 putative GEF interaction site [polypeptide binding]; other site 226900007263 GTP/Mg2+ binding site [chemical binding]; other site 226900007264 Switch I region; other site 226900007265 G2 box; other site 226900007266 G3 box; other site 226900007267 Switch II region; other site 226900007268 G4 box; other site 226900007269 G5 box; other site 226900007270 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 226900007271 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 226900007272 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 226900007273 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 226900007274 nudix motif; other site 226900007275 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 226900007276 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900007277 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 226900007278 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900007279 putative NAD(P) binding site [chemical binding]; other site 226900007280 active site 226900007281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900007284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007285 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900007286 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226900007287 nucleoside/Zn binding site; other site 226900007288 dimer interface [polypeptide binding]; other site 226900007289 catalytic motif [active] 226900007290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007291 Coenzyme A binding pocket [chemical binding]; other site 226900007292 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 226900007293 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 226900007294 nudix motif; other site 226900007295 EamA-like transporter family; Region: EamA; cl01037 226900007296 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900007297 EamA-like transporter family; Region: EamA; cl01037 226900007298 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900007299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900007300 DNA-binding site [nucleotide binding]; DNA binding site 226900007301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007303 homodimer interface [polypeptide binding]; other site 226900007304 catalytic residue [active] 226900007305 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 226900007306 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 226900007307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007308 phosphorylation site [posttranslational modification] 226900007309 dimer interface [polypeptide binding]; other site 226900007310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007311 ATP binding site [chemical binding]; other site 226900007312 Mg2+ binding site [ion binding]; other site 226900007313 G-X-G motif; other site 226900007314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900007315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007316 active site 226900007317 phosphorylation site [posttranslational modification] 226900007318 intermolecular recognition site; other site 226900007319 dimerization interface [polypeptide binding]; other site 226900007320 Helix-turn-helix domains; Region: HTH; cl00088 226900007321 DNA binding site [nucleotide binding] 226900007322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007323 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900007324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007325 active site 226900007326 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900007327 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226900007328 active site 226900007329 metal binding site [ion binding]; metal-binding site 226900007330 Phosphotransferase enzyme family; Region: APH; pfam01636 226900007331 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 226900007332 active site 226900007333 ATP binding site [chemical binding]; other site 226900007334 substrate binding site [chemical binding]; other site 226900007335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900007336 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900007337 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900007338 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007339 Amino acid permease; Region: AA_permease; cl00524 226900007340 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900007341 A new structural DNA glycosylase; Region: AlkD_like; cl11434 226900007342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900007343 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900007344 putative active site [active] 226900007345 nucleotide binding site [chemical binding]; other site 226900007346 nudix motif; other site 226900007347 putative metal binding site [ion binding]; other site 226900007348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900007349 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900007350 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900007351 Catalytic site [active] 226900007352 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900007353 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900007354 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900007355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007356 NAD-dependent deacetylase; Provisional; Region: PRK14138 226900007357 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 226900007358 NAD+ binding site [chemical binding]; other site 226900007359 substrate binding site [chemical binding]; other site 226900007360 Zn binding site [ion binding]; other site 226900007361 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 226900007362 putative substrate binding pocket [chemical binding]; other site 226900007363 AC domain interface; other site 226900007364 catalytic triad [active] 226900007365 AB domain interface; other site 226900007366 interchain disulfide; other site 226900007367 Protein of unknown function (DUF979); Region: DUF979; cl01572 226900007368 Protein of unknown function (DUF969); Region: DUF969; cl01573 226900007369 LamB/YcsF family; Region: LamB_YcsF; cl00664 226900007370 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 226900007371 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 226900007372 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 226900007373 Transcriptional regulator [Transcription]; Region: IclR; COG1414 226900007374 Helix-turn-helix domains; Region: HTH; cl00088 226900007375 Bacterial transcriptional regulator; Region: IclR; pfam01614 226900007376 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900007377 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900007378 Catalytic site [active] 226900007379 CutC family; Region: CutC; cl01218 226900007380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007381 dimerization interface [polypeptide binding]; other site 226900007382 putative DNA binding site [nucleotide binding]; other site 226900007383 putative Zn2+ binding site [ion binding]; other site 226900007384 DinB superfamily; Region: DinB_2; cl00986 226900007385 similar to Acyl-CoA dehydrogenase, short-chain specific; EC_number 1.3.99.2 226900007386 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900007387 putative active site [active] 226900007388 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007389 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 226900007391 Nucleoside recognition; Region: Gate; cl00486 226900007392 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 226900007393 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 226900007394 putative active site [active] 226900007395 putative substrate binding site [chemical binding]; other site 226900007396 ATP binding site [chemical binding]; other site 226900007397 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007399 Coenzyme A binding pocket [chemical binding]; other site 226900007400 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 226900007401 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 226900007402 dinuclear metal binding motif [ion binding]; other site 226900007403 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007404 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900007405 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900007406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007407 Helix-turn-helix domains; Region: HTH; cl00088 226900007408 similar to Immune inhibitor A precursor; EC_number 3.4.24.- 226900007409 phosphoenolpyruvate synthase; Validated; Region: PRK06241 226900007410 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 226900007411 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 226900007412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900007413 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 226900007414 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 226900007415 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900007416 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 226900007417 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900007418 NAD binding site [chemical binding]; other site 226900007419 catalytic Zn binding site [ion binding]; other site 226900007420 structural Zn binding site [ion binding]; other site 226900007421 aspartate ammonia-lyase; Provisional; Region: PRK14515 226900007422 Aspartase; Region: Aspartase; cd01357 226900007423 active sites [active] 226900007424 tetramer interface [polypeptide binding]; other site 226900007425 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 226900007426 active site 226900007427 homodimer interface [polypeptide binding]; other site 226900007428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900007429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900007430 non-specific DNA binding site [nucleotide binding]; other site 226900007431 salt bridge; other site 226900007432 sequence-specific DNA binding site [nucleotide binding]; other site 226900007433 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900007434 Amino acid permease; Region: AA_permease; cl00524 226900007435 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900007436 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900007437 PAS domain S-box; Region: sensory_box; TIGR00229 226900007438 PAS domain S-box; Region: sensory_box; TIGR00229 226900007439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900007440 putative active site [active] 226900007441 heme pocket [chemical binding]; other site 226900007442 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900007443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900007444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007445 dimer interface [polypeptide binding]; other site 226900007446 phosphorylation site [posttranslational modification] 226900007447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007448 ATP binding site [chemical binding]; other site 226900007449 Mg2+ binding site [ion binding]; other site 226900007450 G-X-G motif; other site 226900007451 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900007452 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900007453 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900007454 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900007455 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 226900007456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007458 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900007459 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226900007460 GIY-YIG motif/motif A; other site 226900007461 active site 226900007462 catalytic site [active] 226900007463 putative DNA binding site [nucleotide binding]; other site 226900007464 metal binding site [ion binding]; metal-binding site 226900007465 amino acid transporter; Region: 2A0306; TIGR00909 226900007466 Spore germination protein; Region: Spore_permease; cl15802 226900007467 Spore germination protein; Region: Spore_permease; cl15802 226900007468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007469 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 226900007470 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900007471 Amino acid permease; Region: AA_permease; cl00524 226900007472 similar to Spore germination protein BA 226900007473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007474 Response regulator receiver domain; Region: Response_reg; pfam00072 226900007475 active site 226900007476 phosphorylation site [posttranslational modification] 226900007477 intermolecular recognition site; other site 226900007478 dimerization interface [polypeptide binding]; other site 226900007479 YcbB domain; Region: YcbB; pfam08664 226900007480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900007481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007482 ATP binding site [chemical binding]; other site 226900007483 Mg2+ binding site [ion binding]; other site 226900007484 G-X-G motif; other site 226900007485 Glutaminase; Region: Glutaminase; cl00907 226900007486 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900007487 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 226900007488 transmembrane helices; other site 226900007489 Cytochrome P450; Region: p450; cl12078 226900007490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007491 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 226900007492 Erythromycin esterase; Region: Erythro_esteras; pfam05139 226900007493 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900007494 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 226900007495 putative active site [active] 226900007496 putative metal binding site [ion binding]; other site 226900007497 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900007498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900007500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900007501 Isochorismatase family; Region: Isochorismatase; pfam00857 226900007502 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 226900007503 catalytic triad [active] 226900007504 dimer interface [polypeptide binding]; other site 226900007505 conserved cis-peptide bond; other site 226900007506 Isochorismatase family; Region: Isochorismatase; pfam00857 226900007507 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 226900007508 catalytic triad [active] 226900007509 dimer interface [polypeptide binding]; other site 226900007510 conserved cis-peptide bond; other site 226900007511 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900007512 similar to Exoenzymes regulatory protein aepA precursor 226900007513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900007514 Helix-turn-helix domains; Region: HTH; cl00088 226900007515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900007516 dimerization interface [polypeptide binding]; other site 226900007517 Helix-turn-helix domains; Region: HTH; cl00088 226900007518 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226900007519 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 226900007520 plasmid segregation protein ParM; Provisional; Region: PRK13917 226900007521 Heat induced stress protein YflT; Region: YflT; pfam11181 226900007522 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226900007523 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900007524 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900007525 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 226900007526 TspO/MBR family; Region: TspO_MBR; cl01379 226900007527 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 226900007528 DNA photolyase; Region: DNA_photolyase; pfam00875 226900007529 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 226900007530 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 226900007531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007532 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900007533 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 226900007534 zinc binding site [ion binding]; other site 226900007535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 226900007536 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 226900007537 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 226900007538 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 226900007539 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 226900007540 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 226900007541 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900007542 NodB motif; other site 226900007543 active site 226900007544 catalytic site [active] 226900007545 Zn binding site [ion binding]; other site 226900007546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007547 Coenzyme A binding pocket [chemical binding]; other site 226900007548 UbiA prenyltransferase family; Region: UbiA; cl00337 226900007549 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 226900007550 conserved cys residue [active] 226900007551 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007552 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900007553 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 226900007554 active site 226900007555 Membrane transport protein; Region: Mem_trans; cl09117 226900007556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007557 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 226900007558 putative metal binding site [ion binding]; other site 226900007559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007560 dimerization interface [polypeptide binding]; other site 226900007561 putative DNA binding site [nucleotide binding]; other site 226900007562 putative Zn2+ binding site [ion binding]; other site 226900007563 DinB superfamily; Region: DinB_2; cl00986 226900007564 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 226900007565 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 226900007566 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900007567 putative NAD(P) binding site [chemical binding]; other site 226900007568 active site 226900007569 putative substrate binding site [chemical binding]; other site 226900007570 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007571 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900007572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007573 Helix-turn-helix domains; Region: HTH; cl00088 226900007574 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900007575 Collagenase; Region: Peptidase_M9; pfam01752 226900007576 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900007577 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900007578 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900007579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007580 putative substrate translocation pore; other site 226900007581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007582 Helix-turn-helix domains; Region: HTH; cl00088 226900007583 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 226900007584 Ligand binding site; other site 226900007585 metal-binding site 226900007586 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 226900007587 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 226900007588 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 226900007589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900007590 catalytic loop [active] 226900007591 iron binding site [ion binding]; other site 226900007592 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 226900007593 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 226900007594 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 226900007595 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 226900007596 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007597 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 226900007598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007599 S-adenosylmethionine binding site [chemical binding]; other site 226900007600 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 226900007601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900007602 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 226900007603 NADP binding site [chemical binding]; other site 226900007604 homodimer interface [polypeptide binding]; other site 226900007605 active site 226900007606 substrate binding site [chemical binding]; other site 226900007607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007608 putative DNA binding site [nucleotide binding]; other site 226900007609 putative Zn2+ binding site [ion binding]; other site 226900007610 Helix-turn-helix domains; Region: HTH; cl00088 226900007611 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 226900007612 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900007613 metal binding site [ion binding]; metal-binding site 226900007614 DNA helicase, putative; Region: TIGR00376 226900007615 Erp protein C-terminus; Region: Erp_C; pfam06780 226900007616 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 226900007617 putative active site [active] 226900007618 catalytic site [active] 226900007619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900007620 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007621 active site 226900007622 metal binding site [ion binding]; metal-binding site 226900007623 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 226900007624 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900007625 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900007626 putative active site [active] 226900007627 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900007628 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900007629 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900007630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007632 Amino acid permease; Region: AA_permease; cl00524 226900007633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900007634 Helix-turn-helix domains; Region: HTH; cl00088 226900007635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900007636 dimerization interface [polypeptide binding]; other site 226900007637 EamA-like transporter family; Region: EamA; cl01037 226900007638 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900007639 EamA-like transporter family; Region: EamA; cl01037 226900007640 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 226900007641 DoxX; Region: DoxX; cl00976 226900007642 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900007643 Helix-turn-helix domains; Region: HTH; cl00088 226900007644 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 226900007645 argininosuccinate lyase; Provisional; Region: PRK02186 226900007646 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007648 putative substrate translocation pore; other site 226900007649 Predicted membrane protein [Function unknown]; Region: COG3212 226900007650 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 226900007651 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 226900007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007653 active site 226900007654 phosphorylation site [posttranslational modification] 226900007655 intermolecular recognition site; other site 226900007656 dimerization interface [polypeptide binding]; other site 226900007657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900007658 DNA binding site [nucleotide binding] 226900007659 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226900007660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900007661 dimerization interface [polypeptide binding]; other site 226900007662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007663 dimer interface [polypeptide binding]; other site 226900007664 phosphorylation site [posttranslational modification] 226900007665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007666 ATP binding site [chemical binding]; other site 226900007667 G-X-G motif; other site 226900007668 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226900007669 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 226900007670 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900007671 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 226900007672 Erythromycin esterase; Region: Erythro_esteras; pfam05139 226900007673 Putative sensor; Region: Sensor; pfam13796 226900007674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900007675 Histidine kinase; Region: HisKA_3; pfam07730 226900007676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007677 ATP binding site [chemical binding]; other site 226900007678 Mg2+ binding site [ion binding]; other site 226900007679 G-X-G motif; other site 226900007680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900007681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007682 active site 226900007683 phosphorylation site [posttranslational modification] 226900007684 intermolecular recognition site; other site 226900007685 dimerization interface [polypeptide binding]; other site 226900007686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900007687 DNA binding residues [nucleotide binding] 226900007688 dimerization interface [polypeptide binding]; other site 226900007689 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900007690 putative metal binding site [ion binding]; other site 226900007691 cytochrome P450 83B1; Provisional; Region: PLN03234 226900007692 Cytochrome P450; Region: p450; cl12078 226900007693 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 226900007694 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900007695 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 226900007696 FAD binding pocket [chemical binding]; other site 226900007697 FAD binding motif [chemical binding]; other site 226900007698 catalytic residues [active] 226900007699 NAD binding pocket [chemical binding]; other site 226900007700 phosphate binding motif [ion binding]; other site 226900007701 beta-alpha-beta structure motif; other site 226900007702 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900007703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007704 putative substrate translocation pore; other site 226900007705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007706 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 226900007707 D-cysteine desulfhydrase; Validated; Region: PRK03910 226900007708 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 226900007709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900007710 catalytic residue [active] 226900007711 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900007712 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226900007713 active site 226900007714 metal binding site [ion binding]; metal-binding site 226900007715 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007716 Leucine carboxyl methyltransferase; Region: LCM; cl01306 226900007717 AAA domain; Region: AAA_33; pfam13671 226900007718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900007719 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226900007720 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 226900007721 Gram positive anchor; Region: Gram_pos_anchor; cl15427 226900007722 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900007723 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900007724 Walker A/P-loop; other site 226900007725 ATP binding site [chemical binding]; other site 226900007726 Q-loop/lid; other site 226900007727 ABC transporter signature motif; other site 226900007728 Walker B; other site 226900007729 D-loop; other site 226900007730 H-loop/switch region; other site 226900007731 FtsX-like permease family; Region: FtsX; pfam02687 226900007732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007733 dimerization interface [polypeptide binding]; other site 226900007734 putative DNA binding site [nucleotide binding]; other site 226900007735 Predicted transcriptional regulator [Transcription]; Region: COG2345 226900007736 putative Zn2+ binding site [ion binding]; other site 226900007737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007738 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900007739 putative substrate translocation pore; other site 226900007740 DinB superfamily; Region: DinB_2; cl00986 226900007741 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 226900007742 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900007743 dimerization interface [polypeptide binding]; other site 226900007744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007745 dimer interface [polypeptide binding]; other site 226900007746 phosphorylation site [posttranslational modification] 226900007747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007748 ATP binding site [chemical binding]; other site 226900007749 Mg2+ binding site [ion binding]; other site 226900007750 G-X-G motif; other site 226900007751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900007752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007753 active site 226900007754 phosphorylation site [posttranslational modification] 226900007755 intermolecular recognition site; other site 226900007756 dimerization interface [polypeptide binding]; other site 226900007757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900007758 DNA binding site [nucleotide binding] 226900007759 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900007760 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900007761 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900007762 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 226900007763 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900007764 putative dimer interface [polypeptide binding]; other site 226900007765 catalytic triad [active] 226900007766 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226900007767 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 226900007768 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 226900007769 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 226900007770 active site 226900007771 catalytic residues [active] 226900007772 Acylphosphatase; Region: Acylphosphatase; cl00551 226900007773 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 226900007774 HypF finger; Region: zf-HYPF; pfam07503 226900007775 HypF finger; Region: zf-HYPF; pfam07503 226900007776 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 226900007777 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 226900007778 dimerization interface [polypeptide binding]; other site 226900007779 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 226900007780 ATP binding site [chemical binding]; other site 226900007781 Isochorismatase family; Region: Isochorismatase; pfam00857 226900007782 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900007783 catalytic triad [active] 226900007784 conserved cis-peptide bond; other site 226900007785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900007786 Helix-turn-helix domains; Region: HTH; cl00088 226900007787 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900007788 Amino acid permease; Region: AA_permease; cl00524 226900007789 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 226900007790 similar to hypothetical Cytosolic Protein 226900007791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007792 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 226900007793 L-serine binding site [chemical binding]; other site 226900007794 ACT domain interface; other site 226900007795 Aminotransferase class-V; Region: Aminotran_5; pfam00266 226900007796 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 226900007797 homodimer interface [polypeptide binding]; other site 226900007798 substrate-cofactor binding pocket; other site 226900007799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007800 catalytic residue [active] 226900007801 Domain of unknown function (DUF378); Region: DUF378; cl00943 226900007802 Cupin domain; Region: Cupin_2; cl09118 226900007803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900007804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007805 Penicillin amidase; Region: Penicil_amidase; pfam01804 226900007806 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 226900007807 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 226900007808 active site 226900007809 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 226900007810 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900007811 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900007812 substrate binding site [chemical binding]; other site 226900007813 amidase catalytic site [active] 226900007814 Zn binding residues [ion binding]; other site 226900007815 Bacterial SH3 domain; Region: SH3_3; cl02551 226900007816 S-layer homology domain; Region: SLH; pfam00395 226900007817 S-layer homology domain; Region: SLH; pfam00395 226900007818 S-layer homology domain; Region: SLH; pfam00395 226900007819 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 226900007820 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900007821 Protein of unknown function, DUF600; Region: DUF600; cl04640 226900007822 A new structural DNA glycosylase; Region: AlkD_like; cd06561 226900007823 active site 226900007824 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900007825 Syd protein; Region: Syd; cl06405 226900007826 similar to hypothetical protein 226900007827 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 226900007828 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 226900007829 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900007830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 226900007831 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 226900007832 nucleophilic elbow; other site 226900007833 catalytic triad; other site 226900007834 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 226900007835 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 226900007836 Immunity protein Imm3; Region: Imm3; pfam14425 226900007837 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 226900007838 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900007839 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900007840 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900007841 Protein of unknown function, DUF600; Region: DUF600; cl04640 226900007842 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 226900007843 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 226900007844 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900007845 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 226900007846 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 226900007847 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 226900007848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 226900007849 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 226900007850 Virulence factor EsxB; Region: EsxB; pfam10663 226900007851 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900007852 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 226900007853 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 226900007854 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226900007855 putative active site [active] 226900007856 putative metal binding site [ion binding]; other site 226900007857 NETI protein; Region: NETI; pfam14044 226900007858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007860 putative substrate translocation pore; other site 226900007861 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900007862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007863 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900007864 Helix-turn-helix domains; Region: HTH; cl00088 226900007865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007867 putative substrate translocation pore; other site 226900007868 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900007869 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 226900007870 putative deacylase active site [active] 226900007871 histidyl-tRNA synthetase; Provisional; Region: PRK12420 226900007872 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 226900007873 dimer interface [polypeptide binding]; other site 226900007874 motif 1; other site 226900007875 active site 226900007876 motif 2; other site 226900007877 motif 3; other site 226900007878 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226900007879 anticodon binding site; other site 226900007880 Helix-turn-helix domains; Region: HTH; cl00088 226900007881 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 226900007882 dimer interface [polypeptide binding]; other site 226900007883 FMN binding site [chemical binding]; other site 226900007884 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 226900007885 active site 226900007886 domain interfaces; other site 226900007887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007888 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 226900007889 NAD(P) binding site [chemical binding]; other site 226900007890 active site 226900007891 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900007892 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900007893 Walker A/P-loop; other site 226900007894 ATP binding site [chemical binding]; other site 226900007895 Q-loop/lid; other site 226900007896 ABC transporter signature motif; other site 226900007897 Walker B; other site 226900007898 D-loop; other site 226900007899 H-loop/switch region; other site 226900007900 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 226900007901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900007902 non-specific DNA binding site [nucleotide binding]; other site 226900007903 salt bridge; other site 226900007904 sequence-specific DNA binding site [nucleotide binding]; other site 226900007905 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226900007906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900007907 motif II; other site 226900007908 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 226900007909 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 226900007910 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900007911 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900007912 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900007913 nudix motif; other site 226900007914 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 226900007915 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 226900007916 active site 226900007917 HIGH motif; other site 226900007918 dimer interface [polypeptide binding]; other site 226900007919 KMSKS motif; other site 226900007920 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 226900007921 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 226900007922 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 226900007923 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900007924 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900007925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007926 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007927 Coenzyme A binding pocket [chemical binding]; other site 226900007928 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900007929 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900007930 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900007931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007932 S-adenosylmethionine binding site [chemical binding]; other site 226900007933 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 226900007934 CGNR zinc finger; Region: zf-CGNR; pfam11706 226900007935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007937 putative substrate translocation pore; other site 226900007938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900007939 binding surface 226900007940 TPR motif; other site 226900007941 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 226900007942 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 226900007943 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900007944 hypothetical protein; Provisional; Region: PRK04164 226900007945 ATP synthase I chain; Region: ATP_synt_I; cl09170 226900007946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900007947 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900007948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900007949 Transporter associated domain; Region: CorC_HlyC; cl08393 226900007950 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 226900007951 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900007952 DNA binding residues [nucleotide binding] 226900007953 putative dimer interface [polypeptide binding]; other site 226900007954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007955 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 226900007956 substrate binding site; other site 226900007957 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 226900007958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007959 NAD(P) binding site [chemical binding]; other site 226900007960 active site 226900007961 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 226900007962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900007963 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 226900007964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007965 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900007966 NAD(P) binding site [chemical binding]; other site 226900007967 active site 226900007968 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 226900007969 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 226900007970 EamA-like transporter family; Region: EamA; cl01037 226900007971 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900007972 EamA-like transporter family; Region: EamA; cl01037 226900007973 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 226900007974 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 226900007975 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 226900007976 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 226900007977 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 226900007978 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 226900007979 N- and C-terminal domain interface [polypeptide binding]; other site 226900007980 putative active site [active] 226900007981 catalytic site [active] 226900007982 metal binding site [ion binding]; metal-binding site 226900007983 carbohydrate binding site [chemical binding]; other site 226900007984 ATP binding site [chemical binding]; other site 226900007985 GntP family permease; Region: GntP_permease; cl15264 226900007986 gluconate transporter; Region: gntP; TIGR00791 226900007987 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226900007988 active site 226900007989 intersubunit interactions; other site 226900007990 catalytic residue [active] 226900007991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900007992 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 226900007993 similar to Transketolase; EC_number 2.2.1.1 226900007994 similar to Glucose-6-phosphate 1-dehydrogenase; EC_number 1.1.1.49 226900007995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900007996 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226900007997 putative NAD(P) binding site [chemical binding]; other site 226900007998 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 226900007999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 226900008000 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 226900008001 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 226900008002 putative NAD(P) binding site [chemical binding]; other site 226900008003 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900008004 classical (c) SDRs; Region: SDR_c; cd05233 226900008005 NAD(P) binding site [chemical binding]; other site 226900008006 active site 226900008007 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900008008 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900008009 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900008010 active site 226900008011 Zn binding site [ion binding]; other site 226900008012 Viral enhancin protein; Region: Enhancin; pfam03272 226900008013 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 226900008014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008015 dimerization interface [polypeptide binding]; other site 226900008016 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900008017 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900008018 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 226900008019 catalytic motif [active] 226900008020 Zn binding site [ion binding]; other site 226900008021 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 226900008022 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 226900008023 dimerization interface [polypeptide binding]; other site 226900008024 active site 226900008025 Helix-turn-helix domains; Region: HTH; cl00088 226900008026 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900008027 dimer interface [polypeptide binding]; other site 226900008028 FMN binding site [chemical binding]; other site 226900008029 BNR repeat-like domain; Region: BNR_2; pfam13088 226900008030 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900008031 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900008032 active site 226900008033 catalytic tetrad [active] 226900008034 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900008035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008036 putative substrate translocation pore; other site 226900008037 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 226900008038 active site 1 [active] 226900008039 dimer interface [polypeptide binding]; other site 226900008040 hexamer interface [polypeptide binding]; other site 226900008041 active site 2 [active] 226900008042 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 226900008043 Domain of unknown function (DUF336); Region: DUF336; cl01249 226900008044 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 226900008045 Amino acid permease; Region: AA_permease; cl00524 226900008046 IDEAL domain; Region: IDEAL; cl07452 226900008047 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900008048 Helix-turn-helix domains; Region: HTH; cl00088 226900008049 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 226900008050 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 226900008051 ArsC family; Region: ArsC; pfam03960 226900008052 putative catalytic residues [active] 226900008053 thiol/disulfide switch; other site 226900008054 Helix-turn-helix domains; Region: HTH; cl00088 226900008055 UTRA domain; Region: UTRA; cl01230 226900008056 putative oxidoreductase; Provisional; Region: PRK10206 226900008057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008058 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 226900008059 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 226900008060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900008061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900008062 S-adenosylmethionine binding site [chemical binding]; other site 226900008063 Helix-turn-helix domains; Region: HTH; cl00088 226900008064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008065 dimerization interface [polypeptide binding]; other site 226900008066 putative DNA binding site [nucleotide binding]; other site 226900008067 putative Zn2+ binding site [ion binding]; other site 226900008068 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900008069 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900008070 active site 226900008071 catalytic tetrad [active] 226900008072 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 226900008073 putative hydrophobic ligand binding site [chemical binding]; other site 226900008074 protein interface [polypeptide binding]; other site 226900008075 gate; other site 226900008076 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 226900008077 putative active site [active] 226900008078 putative catalytic triad [active] 226900008079 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 226900008080 catalytic triad [active] 226900008081 oxyanion hole [active] 226900008082 active site 226900008083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900008084 Phosphotransferase enzyme family; Region: APH; pfam01636 226900008085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900008086 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900008087 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 226900008088 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 226900008089 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 226900008090 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900008091 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900008092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008093 dimerization interface [polypeptide binding]; other site 226900008094 putative DNA binding site [nucleotide binding]; other site 226900008095 putative Zn2+ binding site [ion binding]; other site 226900008096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008097 dimerization interface [polypeptide binding]; other site 226900008098 putative DNA binding site [nucleotide binding]; other site 226900008099 putative Zn2+ binding site [ion binding]; other site 226900008100 similar to Glycosyltransferase; EC_number 2.4.1.- 226900008101 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 226900008102 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 226900008103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900008104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900008105 active site 226900008106 LysE type translocator; Region: LysE; cl00565 226900008107 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 226900008108 VPS10 domain; Region: VPS10; smart00602 226900008109 LysE type translocator; Region: LysE; cl00565 226900008110 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 226900008111 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900008112 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900008113 Helix-turn-helix domains; Region: HTH; cl00088 226900008114 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900008115 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900008116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900008117 Walker A/P-loop; other site 226900008118 ATP binding site [chemical binding]; other site 226900008119 Q-loop/lid; other site 226900008120 ABC transporter signature motif; other site 226900008121 Walker B; other site 226900008122 D-loop; other site 226900008123 H-loop/switch region; other site 226900008124 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 226900008125 Helix-turn-helix domains; Region: HTH; cl00088 226900008126 hydroxylamine reductase; Provisional; Region: PRK12310 226900008127 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 226900008128 ACS interaction site; other site 226900008129 CODH interaction site; other site 226900008130 metal cluster binding site [ion binding]; other site 226900008131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900008132 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 226900008133 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900008134 active site 226900008135 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900008136 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 226900008137 hypothetical protein; Provisional; Region: PRK06771 226900008138 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 226900008139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008140 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 226900008141 dimer interface [polypeptide binding]; other site 226900008142 ligand binding site [chemical binding]; other site 226900008143 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900008144 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900008145 ligand binding site [chemical binding]; other site 226900008146 flexible hinge region; other site 226900008147 Protein of unknown function, DUF606; Region: DUF606; cl01273 226900008148 Protein of unknown function, DUF606; Region: DUF606; cl01273 226900008149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900008150 Amino acid permease; Region: AA_permease; cl00524 226900008151 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900008152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008154 putative substrate translocation pore; other site 226900008155 Haemolysin XhlA; Region: XhlA; pfam10779 226900008156 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226900008157 classical (c) SDRs; Region: SDR_c; cd05233 226900008158 NAD(P) binding site [chemical binding]; other site 226900008159 active site 226900008160 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 226900008161 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 226900008162 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 226900008163 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 226900008164 transmembrane helices; other site 226900008165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008166 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900008167 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900008168 putative ligand binding residues [chemical binding]; other site 226900008169 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 226900008170 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 226900008171 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008172 dimer interface [polypeptide binding]; other site 226900008173 ABC-ATPase subunit interface; other site 226900008174 putative PBP binding regions; other site 226900008175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008176 ABC-ATPase subunit interface; other site 226900008177 dimer interface [polypeptide binding]; other site 226900008178 putative PBP binding regions; other site 226900008179 Protein of unknown function (DUF817); Region: DUF817; cl01520 226900008180 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 226900008181 DinB superfamily; Region: DinB_2; cl00986 226900008182 DinB superfamily; Region: DinB_2; cl00986 226900008183 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008184 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900008185 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 226900008186 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 226900008187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008188 Helix-turn-helix domains; Region: HTH; cl00088 226900008189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900008190 dimerization interface [polypeptide binding]; other site 226900008191 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008192 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 226900008193 NADP binding site [chemical binding]; other site 226900008194 dimer interface [polypeptide binding]; other site 226900008195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900008196 catalytic core [active] 226900008197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008198 Coenzyme A binding pocket [chemical binding]; other site 226900008199 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 226900008200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900008201 Walker A/P-loop; other site 226900008202 ATP binding site [chemical binding]; other site 226900008203 Q-loop/lid; other site 226900008204 ABC transporter signature motif; other site 226900008205 Walker B; other site 226900008206 D-loop; other site 226900008207 H-loop/switch region; other site 226900008208 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 226900008209 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 226900008210 active site 226900008211 Na/Ca binding site [ion binding]; other site 226900008212 catalytic site [active] 226900008213 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 226900008214 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900008215 oligoendopeptidase F; Region: pepF; TIGR00181 226900008216 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 226900008217 active site 226900008218 Zn binding site [ion binding]; other site 226900008219 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 226900008220 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226900008221 DNA binding residues [nucleotide binding] 226900008222 drug binding residues [chemical binding]; other site 226900008223 dimer interface [polypeptide binding]; other site 226900008224 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900008225 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 226900008226 Phosphate-starvation-inducible E; Region: PsiE; cl01264 226900008227 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 226900008228 agmatine deiminase; Region: agmatine_aguA; TIGR03380 226900008229 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900008230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008232 putative substrate translocation pore; other site 226900008233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008235 Helix-turn-helix domains; Region: HTH; cl00088 226900008236 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 226900008237 putative dimerization interface [polypeptide binding]; other site 226900008238 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 226900008239 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 226900008240 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 226900008241 active site 226900008242 catalytic site [active] 226900008243 metal binding site [ion binding]; metal-binding site 226900008244 similar to Tetracenomycin polyketide synthesis hydroxylase tcmG; EC_number 1.14.13.- 226900008245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008246 dimerization interface [polypeptide binding]; other site 226900008247 putative DNA binding site [nucleotide binding]; other site 226900008248 putative Zn2+ binding site [ion binding]; other site 226900008249 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008250 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226900008251 putative NAD(P) binding site [chemical binding]; other site 226900008252 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 226900008253 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 226900008254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 226900008255 TPR motif; other site 226900008256 binding surface 226900008257 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 226900008258 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 226900008259 FAD binding domain; Region: FAD_binding_4; pfam01565 226900008260 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 226900008261 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008262 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900008263 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900008264 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900008265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900008266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 226900008267 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900008268 active site residue [active] 226900008269 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 226900008270 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 226900008271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900008272 active site 226900008273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900008274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008275 NAD(P) binding site [chemical binding]; other site 226900008276 active site 226900008277 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 226900008278 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 226900008279 NAD binding site [chemical binding]; other site 226900008280 homotetramer interface [polypeptide binding]; other site 226900008281 homodimer interface [polypeptide binding]; other site 226900008282 substrate binding site [chemical binding]; other site 226900008283 active site 226900008284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008285 TPR motif; other site 226900008286 binding surface 226900008287 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 226900008288 dimerization interface [polypeptide binding]; other site 226900008289 ligand (aspartate) binding pocket [chemical binding]; other site 226900008290 Cache domain; Region: Cache_1; pfam02743 226900008291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008292 dimerization interface [polypeptide binding]; other site 226900008293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900008294 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900008295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008296 Helix-turn-helix domains; Region: HTH; cl00088 226900008297 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 226900008298 S-layer homology domain; Region: SLH; pfam00395 226900008299 S-layer homology domain; Region: SLH; pfam00395 226900008300 S-layer homology domain; Region: SLH; pfam00395 226900008301 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900008302 active site 226900008303 metal binding site [ion binding]; metal-binding site 226900008304 TQXA domain; Region: TQXA_dom; TIGR03934 226900008305 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900008306 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900008307 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900008308 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900008309 Gram positive anchor; Region: Gram_pos_anchor; cl15427 226900008310 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900008311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008312 dimer interface [polypeptide binding]; other site 226900008313 phosphorylation site [posttranslational modification] 226900008314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008315 ATP binding site [chemical binding]; other site 226900008316 Mg2+ binding site [ion binding]; other site 226900008317 G-X-G motif; other site 226900008318 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900008319 Collagenase; Region: Peptidase_M9; pfam01752 226900008320 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900008321 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900008322 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 226900008323 MgtC family; Region: MgtC; cl12207 226900008324 Predicted acetyltransferase [General function prediction only]; Region: COG3981 226900008325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008326 Coenzyme A binding pocket [chemical binding]; other site 226900008327 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900008328 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 226900008329 putative metal binding site [ion binding]; other site 226900008330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900008331 active site 226900008332 metal binding site [ion binding]; metal-binding site 226900008333 VanW like protein; Region: VanW; pfam04294 226900008334 Sensor protein DegS; Region: DegS; pfam05384 226900008335 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 226900008336 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 226900008337 exonuclease; Provisional; Region: PRK06722 226900008338 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 226900008339 active site 226900008340 substrate binding site [chemical binding]; other site 226900008341 catalytic site [active] 226900008342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900008343 DNA-binding site [nucleotide binding]; DNA binding site 226900008344 RNA-binding motif; other site 226900008345 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900008346 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 226900008347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900008348 nudix motif; other site 226900008349 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 226900008350 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900008351 trimer interface [polypeptide binding]; other site 226900008352 active site 226900008353 substrate binding site [chemical binding]; other site 226900008354 CoA binding site [chemical binding]; other site 226900008355 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008356 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008357 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008358 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008359 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008360 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008361 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008362 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008363 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008364 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008365 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008366 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008367 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008368 Domain of unknown function DUF11; Region: DUF11; cl15273 226900008369 short chain dehydrogenase; Provisional; Region: PRK06924 226900008370 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 226900008371 NADP binding site [chemical binding]; other site 226900008372 homodimer interface [polypeptide binding]; other site 226900008373 active site 226900008374 Predicted acetyltransferase [General function prediction only]; Region: COG3393 226900008375 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900008376 argininosuccinate lyase; Provisional; Region: PRK06705 226900008377 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 226900008378 active sites [active] 226900008379 tetramer interface [polypeptide binding]; other site 226900008380 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 226900008381 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 226900008382 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900008383 active site 226900008384 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 226900008385 Sodium:solute symporter family; Region: SSF; cl00456 226900008386 Protein of unknown function (DUF997); Region: DUF997; cl01614 226900008387 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 226900008388 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 226900008389 NAD(P) binding site [chemical binding]; other site 226900008390 catalytic residues [active] 226900008391 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900008392 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226900008393 NAD(P) binding site [chemical binding]; other site 226900008394 homotetramer interface [polypeptide binding]; other site 226900008395 homodimer interface [polypeptide binding]; other site 226900008396 active site 226900008397 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 226900008398 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 226900008399 Divergent PAP2 family; Region: DUF212; cl00855 226900008400 Predicted permeases [General function prediction only]; Region: RarD; COG2962 226900008401 EamA-like transporter family; Region: EamA; cl01037 226900008402 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 226900008403 Domain of unknown function DUF59; Region: DUF59; cl00941 226900008404 antiporter inner membrane protein; Provisional; Region: PRK11670 226900008405 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 226900008406 Walker A motif; other site 226900008407 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900008408 MoaE interaction surface [polypeptide binding]; other site 226900008409 MoeB interaction surface [polypeptide binding]; other site 226900008410 thiocarboxylated glycine; other site 226900008411 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900008412 MoaE homodimer interface [polypeptide binding]; other site 226900008413 MoaD interaction [polypeptide binding]; other site 226900008414 active site residues [active] 226900008415 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900008416 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900008417 dimer interface [polypeptide binding]; other site 226900008418 putative functional site; other site 226900008419 putative MPT binding site; other site 226900008420 similar to Molybdopterin biosynthesis MoeB protein 226900008421 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 226900008422 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 226900008423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900008424 FeS/SAM binding site; other site 226900008425 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900008426 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 226900008427 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 226900008428 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 226900008429 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 226900008430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900008431 catalytic loop [active] 226900008432 iron binding site [ion binding]; other site 226900008433 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 226900008434 4Fe-4S binding domain; Region: Fer4; cl02805 226900008435 4Fe-4S binding domain; Region: Fer4; cl02805 226900008436 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 226900008437 [4Fe-4S] binding site [ion binding]; other site 226900008438 molybdopterin cofactor binding site; other site 226900008439 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 226900008440 molybdopterin cofactor binding site; other site 226900008441 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900008442 Amino acid permease; Region: AA_permease; cl00524 226900008443 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900008444 Amino acid permease; Region: AA_permease; cl00524 226900008445 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900008446 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 226900008447 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 226900008448 metal ion-dependent adhesion site (MIDAS); other site 226900008449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900008450 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900008451 active site 226900008452 metal binding site [ion binding]; metal-binding site 226900008453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900008454 S-adenosylmethionine binding site [chemical binding]; other site 226900008455 O-methyltransferase; Region: Methyltransf_2; pfam00891 226900008456 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900008457 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900008458 peptide binding site [polypeptide binding]; other site 226900008459 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900008460 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900008461 peptide binding site [polypeptide binding]; other site 226900008462 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900008463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900008464 peptide binding site [polypeptide binding]; other site 226900008465 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900008466 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 226900008467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900008468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900008469 DNA binding residues [nucleotide binding] 226900008470 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900008471 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900008472 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900008473 Walker A/P-loop; other site 226900008474 ATP binding site [chemical binding]; other site 226900008475 Q-loop/lid; other site 226900008476 ABC transporter signature motif; other site 226900008477 Walker B; other site 226900008478 D-loop; other site 226900008479 H-loop/switch region; other site 226900008480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008481 Helix-turn-helix domains; Region: HTH; cl00088 226900008482 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900008483 Helix-turn-helix domains; Region: HTH; cl00088 226900008484 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900008485 dimer interface [polypeptide binding]; other site 226900008486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900008487 putative oxidoreductase; Provisional; Region: PRK11579 226900008488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008489 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 226900008490 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 226900008491 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 226900008492 CAP-like domain; other site 226900008493 active site 226900008494 primary dimer interface [polypeptide binding]; other site 226900008495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900008496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900008497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900008498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900008499 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226900008500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008501 ATP binding site [chemical binding]; other site 226900008502 Mg2+ binding site [ion binding]; other site 226900008503 G-X-G motif; other site 226900008504 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226900008505 anchoring element; other site 226900008506 dimer interface [polypeptide binding]; other site 226900008507 ATP binding site [chemical binding]; other site 226900008508 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 226900008509 active site 226900008510 putative metal-binding site [ion binding]; other site 226900008511 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226900008512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008513 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 226900008514 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900008515 protein binding site [polypeptide binding]; other site 226900008516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900008517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900008518 active site 226900008519 phosphorylation site [posttranslational modification] 226900008520 intermolecular recognition site; other site 226900008521 dimerization interface [polypeptide binding]; other site 226900008522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900008523 DNA binding site [nucleotide binding] 226900008524 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 226900008525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900008526 FeS/SAM binding site; other site 226900008527 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 226900008528 Class III ribonucleotide reductase; Region: RNR_III; cd01675 226900008529 effector binding site; other site 226900008530 active site 226900008531 Zn binding site [ion binding]; other site 226900008532 glycine loop; other site 226900008533 Domain of unknown function (DUF205); Region: DUF205; cl00410 226900008534 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226900008535 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226900008536 active site 226900008537 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 226900008538 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900008539 putative peptidoglycan binding site; other site 226900008540 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900008541 putative peptidoglycan binding site; other site 226900008542 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 226900008543 active site 226900008544 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 226900008545 Small acid-soluble spore protein N family; Region: SspN; cl11659 226900008546 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 226900008547 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226900008548 active site 226900008549 substrate binding site [chemical binding]; other site 226900008550 catalytic site [active] 226900008551 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900008552 catalytic residues [active] 226900008553 similar to hypothetical protein 226900008554 similar to Multidrug resistance ABC transporter ATP-binding and permease 226900008555 aconitate hydratase; Validated; Region: PRK09277 226900008556 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 226900008557 substrate binding site [chemical binding]; other site 226900008558 ligand binding site [chemical binding]; other site 226900008559 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 226900008560 substrate binding site [chemical binding]; other site 226900008561 Small acid-soluble spore protein O family; Region: SspO; cl07943 226900008562 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 226900008563 NodB motif; other site 226900008564 active site 226900008565 catalytic site [active] 226900008566 metal binding site [ion binding]; metal-binding site 226900008567 Small acid-soluble spore protein P family; Region: SspP; cl12105 226900008568 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 226900008569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008571 putative substrate translocation pore; other site 226900008572 similar to Metal-dependent hydrolase related to alanyl-tRNA synthetase 226900008573 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900008574 nudix motif; other site 226900008575 SAP domain; Region: SAP; cl02640 226900008576 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 226900008577 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900008578 dimer interface [polypeptide binding]; other site 226900008579 active site 226900008580 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900008581 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 226900008582 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900008583 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900008584 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 226900008585 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900008586 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008587 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900008588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008589 Coenzyme A binding pocket [chemical binding]; other site 226900008590 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 226900008591 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900008592 amidase catalytic site [active] 226900008593 Zn binding residues [ion binding]; other site 226900008594 substrate binding site [chemical binding]; other site 226900008595 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900008596 active site 226900008597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900008598 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900008599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900008600 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 226900008601 dimer interface [polypeptide binding]; other site 226900008602 putative metal binding site [ion binding]; other site 226900008603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900008604 putative active site [active] 226900008605 heme pocket [chemical binding]; other site 226900008606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900008607 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226900008608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008609 dimer interface [polypeptide binding]; other site 226900008610 phosphorylation site [posttranslational modification] 226900008611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008612 ATP binding site [chemical binding]; other site 226900008613 Mg2+ binding site [ion binding]; other site 226900008614 G-X-G motif; other site 226900008615 Predicted esterase [General function prediction only]; Region: COG0400 226900008616 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900008617 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900008618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900008619 Zn binding site [ion binding]; other site 226900008620 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900008621 Zn binding site [ion binding]; other site 226900008622 Sodium:solute symporter family; Region: SSF; cl00456 226900008623 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 226900008624 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 226900008625 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 226900008626 active site 226900008627 FMN binding site [chemical binding]; other site 226900008628 substrate binding site [chemical binding]; other site 226900008629 3Fe-4S cluster binding site [ion binding]; other site 226900008630 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 226900008631 FMN binding site [chemical binding]; other site 226900008632 active site 226900008633 substrate binding site [chemical binding]; other site 226900008634 catalytic residue [active] 226900008635 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 226900008636 similar to Formiminoglutamase; EC_number 3.5.3.8 226900008637 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 226900008638 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 226900008639 active site 226900008640 urocanate hydratase; Provisional; Region: PRK05414 226900008641 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 226900008642 active sites [active] 226900008643 tetramer interface [polypeptide binding]; other site 226900008644 HutP; Region: HutP; cl07944 226900008645 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226900008646 conserved cys residue [active] 226900008647 AAA domain; Region: AAA_28; pfam13521 226900008648 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 226900008649 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 226900008650 LysE type translocator; Region: LysE; cl00565 226900008651 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900008652 EamA-like transporter family; Region: EamA; cl01037 226900008653 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900008654 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 226900008655 metal binding site [ion binding]; metal-binding site 226900008656 dimer interface [polypeptide binding]; other site 226900008657 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900008658 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900008659 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900008660 Walker A/P-loop; other site 226900008661 ATP binding site [chemical binding]; other site 226900008662 Q-loop/lid; other site 226900008663 ABC transporter signature motif; other site 226900008664 Walker B; other site 226900008665 D-loop; other site 226900008666 H-loop/switch region; other site 226900008667 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 226900008668 Helix-turn-helix domains; Region: HTH; cl00088 226900008669 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 226900008670 putative dimerization interface [polypeptide binding]; other site 226900008671 putative substrate binding pocket [chemical binding]; other site 226900008672 LrgA family; Region: LrgA; cl00608 226900008673 LrgB-like family; Region: LrgB; cl00596 226900008674 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900008675 nudix motif; other site 226900008676 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 226900008677 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 226900008678 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 226900008679 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900008680 active site 226900008681 Bacterial SH3 domain; Region: SH3_3; cl02551 226900008682 Bacterial SH3 domain; Region: SH3_3; cl02551 226900008683 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 226900008684 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900008685 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 226900008686 Walker A/P-loop; other site 226900008687 ATP binding site [chemical binding]; other site 226900008688 Q-loop/lid; other site 226900008689 ABC transporter signature motif; other site 226900008690 Walker B; other site 226900008691 D-loop; other site 226900008692 H-loop/switch region; other site 226900008693 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900008694 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 226900008695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900008696 Walker A/P-loop; other site 226900008697 ATP binding site [chemical binding]; other site 226900008698 Q-loop/lid; other site 226900008699 ABC transporter signature motif; other site 226900008700 Walker B; other site 226900008701 D-loop; other site 226900008702 H-loop/switch region; other site 226900008703 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 226900008704 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 226900008705 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 226900008706 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 226900008707 TPP-binding site [chemical binding]; other site 226900008708 dimer interface [polypeptide binding]; other site 226900008709 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226900008710 PYR/PP interface [polypeptide binding]; other site 226900008711 dimer interface [polypeptide binding]; other site 226900008712 TPP binding site [chemical binding]; other site 226900008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900008714 dimer interface [polypeptide binding]; other site 226900008715 conserved gate region; other site 226900008716 ABC-ATPase subunit interface; other site 226900008717 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 226900008718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900008719 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 226900008720 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 226900008721 Walker A/P-loop; other site 226900008722 ATP binding site [chemical binding]; other site 226900008723 Q-loop/lid; other site 226900008724 ABC transporter signature motif; other site 226900008725 Walker B; other site 226900008726 D-loop; other site 226900008727 H-loop/switch region; other site 226900008728 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 226900008729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900008730 membrane-bound complex binding site; other site 226900008731 hinge residues; other site 226900008732 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900008733 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 226900008734 active site 226900008735 metal binding site [ion binding]; metal-binding site 226900008736 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900008737 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 226900008738 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226900008739 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 226900008740 catalytic residues [active] 226900008741 catalytic nucleophile [active] 226900008742 Helix-turn-helix domains; Region: HTH; cl00088 226900008743 LexA repressor; Validated; Region: PRK00215 226900008744 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226900008745 Catalytic site [active] 226900008746 Uncharacterized conserved protein [Function unknown]; Region: COG3595 226900008747 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 226900008748 Helix-turn-helix domains; Region: HTH; cl00088 226900008749 Bacteriophage ph6A53; inactive remnant; detected in Bacillus thuringiensis var. israelensis 226900008750 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900008751 amidase catalytic site [active] 226900008752 Zn binding residues [ion binding]; other site 226900008753 substrate binding site [chemical binding]; other site 226900008754 Bacterial SH3 domain; Region: SH3_3; cl02551 226900008755 Haemolysin XhlA; Region: XhlA; pfam10779 226900008756 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900008757 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 226900008758 catalytic residue [active] 226900008759 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 226900008760 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226900008761 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900008762 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 226900008763 ORF6C domain; Region: ORF6C; pfam10552 226900008764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900008765 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 226900008766 non-specific DNA binding site [nucleotide binding]; other site 226900008767 salt bridge; other site 226900008768 sequence-specific DNA binding site [nucleotide binding]; other site 226900008769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226900008770 Catalytic site [active] 226900008771 similar to Glutamine synthetase; EC_number 6.3.1.2 226900008772 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 226900008773 DNA binding residues [nucleotide binding] 226900008774 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 226900008775 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900008776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900008777 catalytic residue [active] 226900008778 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226900008779 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 226900008780 G1 box; other site 226900008781 GTP/Mg2+ binding site [chemical binding]; other site 226900008782 Switch I region; other site 226900008783 G2 box; other site 226900008784 G3 box; other site 226900008785 Switch II region; other site 226900008786 G4 box; other site 226900008787 G5 box; other site 226900008788 Predicted membrane protein [Function unknown]; Region: COG2860 226900008789 UPF0126 domain; Region: UPF0126; pfam03458 226900008790 UPF0126 domain; Region: UPF0126; pfam03458 226900008791 similar to Stage V sporulation protein K 226900008792 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 226900008793 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900008794 DNA binding site [nucleotide binding] 226900008795 active site 226900008796 Int/Topo IB signature motif; other site 226900008797 catalytic residues [active] 226900008798 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 226900008799 Sm1 motif; other site 226900008800 intra - hexamer interaction site; other site 226900008801 inter - hexamer interaction site [polypeptide binding]; other site 226900008802 nucleotide binding pocket [chemical binding]; other site 226900008803 Sm2 motif; other site 226900008804 IPP transferase; Region: IPPT; cl00403 226900008805 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 226900008806 similar to enterotoxin / cell-wall binding protein 226900008807 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 226900008808 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226900008809 active site 226900008810 phosphorylation site [posttranslational modification] 226900008811 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 226900008812 P-loop; other site 226900008813 active site 226900008814 phosphorylation site [posttranslational modification] 226900008815 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900008816 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 226900008817 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 226900008818 putative substrate binding site [chemical binding]; other site 226900008819 putative ATP binding site [chemical binding]; other site 226900008820 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900008821 Helix-turn-helix domains; Region: HTH; cl00088 226900008822 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 226900008823 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 226900008824 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 226900008825 dimer interface [polypeptide binding]; other site 226900008826 active site 226900008827 metal binding site [ion binding]; metal-binding site 226900008828 Protein of unknown function (DUF420); Region: DUF420; cl00989 226900008829 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900008830 Amino acid permease; Region: AA_permease; cl00524 226900008831 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 226900008832 Glyco_18 domain; Region: Glyco_18; smart00636 226900008833 putative active site [active] 226900008834 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900008835 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900008836 putative active site [active] 226900008837 putative metal binding site [ion binding]; other site 226900008838 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 226900008839 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 226900008840 IHF dimer interface [polypeptide binding]; other site 226900008841 IHF - DNA interface [nucleotide binding]; other site 226900008842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008843 Coenzyme A binding pocket [chemical binding]; other site 226900008844 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900008845 metal-binding site [ion binding] 226900008846 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226900008847 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900008848 metal-binding site [ion binding] 226900008849 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900008850 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900008851 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900008852 metal-binding site [ion binding] 226900008853 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 226900008854 putative homotetramer interface [polypeptide binding]; other site 226900008855 putative homodimer interface [polypeptide binding]; other site 226900008856 allosteric switch controlling residues; other site 226900008857 putative metal binding site [ion binding]; other site 226900008858 putative homodimer-homodimer interface [polypeptide binding]; other site 226900008859 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900008860 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900008861 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900008862 Walker A/P-loop; other site 226900008863 ATP binding site [chemical binding]; other site 226900008864 Q-loop/lid; other site 226900008865 ABC transporter signature motif; other site 226900008866 Walker B; other site 226900008867 D-loop; other site 226900008868 H-loop/switch region; other site 226900008869 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008870 ABC-ATPase subunit interface; other site 226900008871 dimer interface [polypeptide binding]; other site 226900008872 putative PBP binding regions; other site 226900008873 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008874 ABC-ATPase subunit interface; other site 226900008875 dimer interface [polypeptide binding]; other site 226900008876 putative PBP binding regions; other site 226900008877 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900008878 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 226900008879 putative ligand binding residues [chemical binding]; other site 226900008880 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 226900008881 active site 226900008882 DNA binding site [nucleotide binding] 226900008883 putative phosphate binding site [ion binding]; other site 226900008884 putative catalytic site [active] 226900008885 metal binding site A [ion binding]; metal-binding site 226900008886 AP binding site [nucleotide binding]; other site 226900008887 metal binding site B [ion binding]; metal-binding site 226900008888 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 226900008889 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 226900008890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900008891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900008892 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 226900008893 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226900008894 DNA binding site [nucleotide binding] 226900008895 active site 226900008896 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 226900008897 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900008898 endonuclease III; Region: ENDO3c; smart00478 226900008899 minor groove reading motif; other site 226900008900 helix-hairpin-helix signature motif; other site 226900008901 substrate binding pocket [chemical binding]; other site 226900008902 active site 226900008903 peptidase T; Region: peptidase-T; TIGR01882 226900008904 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 226900008905 metal binding site [ion binding]; metal-binding site 226900008906 dimer interface [polypeptide binding]; other site 226900008907 hypothetical protein; Provisional; Region: PRK06764 226900008908 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900008909 catalytic core [active] 226900008910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900008911 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900008912 PAS domain S-box; Region: sensory_box; TIGR00229 226900008913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900008914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900008915 metal binding site [ion binding]; metal-binding site 226900008916 active site 226900008917 I-site; other site 226900008918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900008919 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 226900008920 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900008921 active site 226900008922 homodimer interface [polypeptide binding]; other site 226900008923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008924 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900008925 NAD(P) binding site [chemical binding]; other site 226900008926 active site 226900008927 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226900008928 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 226900008929 NAD(P) binding site [chemical binding]; other site 226900008930 homodimer interface [polypeptide binding]; other site 226900008931 substrate binding site [chemical binding]; other site 226900008932 active site 226900008933 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 226900008934 similar to hypothetical protein 226900008935 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 226900008936 LrgB-like family; Region: LrgB; cl00596 226900008937 LrgA family; Region: LrgA; cl00608 226900008938 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900008939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900008940 DNA-binding site [nucleotide binding]; DNA binding site 226900008941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900008942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900008943 homodimer interface [polypeptide binding]; other site 226900008944 catalytic residue [active] 226900008945 UTRA domain; Region: UTRA; cl01230 226900008946 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 226900008947 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 226900008948 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 226900008949 active site 226900008950 catalytic site [active] 226900008951 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 226900008952 putative active site [active] 226900008953 putative catalytic triad [active] 226900008954 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900008955 similar to cell wall hydrolase cwlJ 226900008956 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 226900008957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008958 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900008959 Sulfatase; Region: Sulfatase; cl10460 226900008960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008961 binding surface 226900008962 TPR motif; other site 226900008963 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 226900008964 G1 box; other site 226900008965 GTP/Mg2+ binding site [chemical binding]; other site 226900008966 Switch I region; other site 226900008967 G2 box; other site 226900008968 Switch II region; other site 226900008969 G3 box; other site 226900008970 G4 box; other site 226900008971 G5 box; other site 226900008972 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 226900008973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008974 ATP binding site [chemical binding]; other site 226900008975 Mg2+ binding site [ion binding]; other site 226900008976 G-X-G motif; other site 226900008977 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 226900008978 ATP binding site [chemical binding]; other site 226900008979 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 226900008980 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 226900008981 MutS domain I; Region: MutS_I; pfam01624 226900008982 MutS domain II; Region: MutS_II; pfam05188 226900008983 MutS family domain IV; Region: MutS_IV; pfam05190 226900008984 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 226900008985 Walker A/P-loop; other site 226900008986 ATP binding site [chemical binding]; other site 226900008987 Q-loop/lid; other site 226900008988 ABC transporter signature motif; other site 226900008989 Walker B; other site 226900008990 D-loop; other site 226900008991 H-loop/switch region; other site 226900008992 Outer spore coat protein E (CotE); Region: CotE; pfam10628 226900008993 Protein of unknown function (DUF964); Region: DUF964; cl01483 226900008994 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 226900008995 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226900008996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900008997 FeS/SAM binding site; other site 226900008998 TRAM domain; Region: TRAM; cl01282 226900008999 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 226900009000 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 226900009001 TPP-binding site [chemical binding]; other site 226900009002 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 226900009003 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 226900009004 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 226900009005 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226900009006 dimer interface [polypeptide binding]; other site 226900009007 PYR/PP interface [polypeptide binding]; other site 226900009008 TPP binding site [chemical binding]; other site 226900009009 substrate binding site [chemical binding]; other site 226900009010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900009011 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 226900009012 active site 226900009013 dimer interface [polypeptide binding]; other site 226900009014 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 226900009015 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900009016 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 226900009017 putative active site [active] 226900009018 metal binding site [ion binding]; metal-binding site 226900009019 homodimer binding site [polypeptide binding]; other site 226900009020 phosphodiesterase; Provisional; Region: PRK12704 226900009021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900009022 recombinase A; Provisional; Region: recA; PRK09354 226900009023 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 226900009024 hexamer interface [polypeptide binding]; other site 226900009025 Walker A motif; other site 226900009026 ATP binding site [chemical binding]; other site 226900009027 Walker B motif; other site 226900009028 competence damage-inducible protein A; Provisional; Region: PRK00549 226900009029 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 226900009030 putative MPT binding site; other site 226900009031 Competence-damaged protein; Region: CinA; cl00666 226900009032 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900009033 Helix-turn-helix domains; Region: HTH; cl00088 226900009034 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226900009035 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 226900009036 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 226900009037 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226900009038 classical (c) SDRs; Region: SDR_c; cd05233 226900009039 NAD(P) binding site [chemical binding]; other site 226900009040 active site 226900009041 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009042 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226900009043 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009044 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009045 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009046 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 226900009047 TM-ABC transporter signature motif; other site 226900009048 similar to nucleoside transport system permease 226900009049 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 226900009050 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 226900009051 Walker A/P-loop; other site 226900009052 ATP binding site [chemical binding]; other site 226900009053 Q-loop/lid; other site 226900009054 ABC transporter signature motif; other site 226900009055 Walker B; other site 226900009056 D-loop; other site 226900009057 H-loop/switch region; other site 226900009058 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 226900009059 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 226900009060 ligand binding site [chemical binding]; other site 226900009061 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900009062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900009063 DNA-binding site [nucleotide binding]; DNA binding site 226900009064 UTRA domain; Region: UTRA; cl01230 226900009065 Tetraspanin family; Region: Tetraspannin; pfam00335 226900009066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900009067 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 226900009068 YlzJ-like protein; Region: YlzJ; pfam14035 226900009069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 226900009070 active site 226900009071 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900009072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900009073 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 226900009074 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 226900009075 dihydrodipicolinate synthase; Region: dapA; TIGR00674 226900009076 dimer interface [polypeptide binding]; other site 226900009077 active site 226900009078 catalytic residue [active] 226900009079 aspartate kinase I; Reviewed; Region: PRK08210 226900009080 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 226900009081 nucleotide binding site [chemical binding]; other site 226900009082 substrate binding site [chemical binding]; other site 226900009083 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 226900009084 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226900009085 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 226900009086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009087 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 226900009088 Flavoprotein; Region: Flavoprotein; cl08021 226900009089 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 226900009090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009091 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 226900009092 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009093 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226900009094 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009095 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 226900009096 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 226900009097 NodB motif; other site 226900009098 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 226900009099 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 226900009100 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 226900009101 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 226900009102 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 226900009103 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 226900009104 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 226900009105 putative nucleic acid binding region [nucleotide binding]; other site 226900009106 G-X-X-G motif; other site 226900009107 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 226900009108 RNA binding site [nucleotide binding]; other site 226900009109 domain interface; other site 226900009110 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 226900009111 16S/18S rRNA binding site [nucleotide binding]; other site 226900009112 S13e-L30e interaction site [polypeptide binding]; other site 226900009113 25S rRNA binding site [nucleotide binding]; other site 226900009114 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 226900009115 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 226900009116 active site 226900009117 Riboflavin kinase; Region: Flavokinase; cl03312 226900009118 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 226900009119 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 226900009120 RNA binding site [nucleotide binding]; other site 226900009121 active site 226900009122 Ribosome-binding factor A; Region: RBFA; cl00542 226900009123 Protein of unknown function (DUF503); Region: DUF503; cl00669 226900009124 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226900009125 translation initiation factor IF-2; Region: IF-2; TIGR00487 226900009126 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226900009127 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 226900009128 G1 box; other site 226900009129 putative GEF interaction site [polypeptide binding]; other site 226900009130 GTP/Mg2+ binding site [chemical binding]; other site 226900009131 Switch I region; other site 226900009132 G2 box; other site 226900009133 G3 box; other site 226900009134 Switch II region; other site 226900009135 G4 box; other site 226900009136 G5 box; other site 226900009137 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 226900009138 Translation-initiation factor 2; Region: IF-2; pfam11987 226900009139 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 226900009140 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 226900009141 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 226900009142 putative RNA binding cleft [nucleotide binding]; other site 226900009143 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 226900009144 NusA N-terminal domain; Region: NusA_N; pfam08529 226900009145 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 226900009146 RNA binding site [nucleotide binding]; other site 226900009147 homodimer interface [polypeptide binding]; other site 226900009148 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226900009149 G-X-X-G motif; other site 226900009150 ribosome maturation protein RimP; Reviewed; Region: PRK00092 226900009151 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 226900009152 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 226900009153 Sm1 motif; other site 226900009154 predicted subunit interaction site [polypeptide binding]; other site 226900009155 RNA binding pocket [nucleotide binding]; other site 226900009156 Sm2 motif; other site 226900009157 DNA polymerase III PolC; Validated; Region: polC; PRK00448 226900009158 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 226900009159 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 226900009160 generic binding surface II; other site 226900009161 generic binding surface I; other site 226900009162 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 226900009163 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226900009164 active site 226900009165 substrate binding site [chemical binding]; other site 226900009166 catalytic site [active] 226900009167 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226900009168 prolyl-tRNA synthetase; Provisional; Region: PRK09194 226900009169 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 226900009170 dimer interface [polypeptide binding]; other site 226900009171 motif 1; other site 226900009172 active site 226900009173 motif 2; other site 226900009174 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 226900009175 putative deacylase active site [active] 226900009176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 226900009177 active site 226900009178 motif 3; other site 226900009179 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 226900009180 anticodon binding site; other site 226900009181 similar to membrane metalloprotease 226900009182 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 226900009183 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 226900009184 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 226900009185 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 226900009186 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 226900009187 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 226900009188 catalytic residue [active] 226900009189 putative FPP diphosphate binding site; other site 226900009190 putative FPP binding hydrophobic cleft; other site 226900009191 dimer interface [polypeptide binding]; other site 226900009192 putative IPP diphosphate binding site; other site 226900009193 ribosome recycling factor; Reviewed; Region: frr; PRK00083 226900009194 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 226900009195 hinge region; other site 226900009196 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226900009197 putative nucleotide binding site [chemical binding]; other site 226900009198 uridine monophosphate binding site [chemical binding]; other site 226900009199 homohexameric interface [polypeptide binding]; other site 226900009200 elongation factor Ts; Provisional; Region: tsf; PRK09377 226900009201 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 226900009202 Elongation factor TS; Region: EF_TS; pfam00889 226900009203 Elongation factor TS; Region: EF_TS; pfam00889 226900009204 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 226900009205 rRNA interaction site [nucleotide binding]; other site 226900009206 S8 interaction site; other site 226900009207 putative laminin-1 binding site; other site 226900009208 transcriptional repressor CodY; Validated; Region: PRK04158 226900009209 CodY GAF-like domain; Region: CodY; pfam06018 226900009210 Helix-turn-helix domains; Region: HTH; cl00088 226900009211 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 226900009212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900009213 Walker A motif; other site 226900009214 ATP binding site [chemical binding]; other site 226900009215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900009216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 226900009217 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 226900009218 active site 226900009219 HslU subunit interaction site [polypeptide binding]; other site 226900009220 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 226900009221 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226900009222 Int/Topo IB signature motif; other site 226900009223 active site 226900009224 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 226900009225 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 226900009226 DNA topoisomerase I; Validated; Region: PRK05582 226900009227 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 226900009228 active site 226900009229 metal binding site [ion binding]; metal-binding site 226900009230 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900009231 domain I; other site 226900009232 DNA binding groove [nucleotide binding] 226900009233 phosphate binding site [ion binding]; other site 226900009234 domain II; other site 226900009235 domain III; other site 226900009236 nucleotide binding site [chemical binding]; other site 226900009237 catalytic site [active] 226900009238 domain IV; other site 226900009239 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900009240 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900009241 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 226900009242 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 226900009243 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 226900009244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009245 CoA-ligase; Region: Ligase_CoA; pfam00549 226900009246 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 226900009247 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900009248 CoA-ligase; Region: Ligase_CoA; pfam00549 226900009249 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 226900009250 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900009251 active site 226900009252 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 226900009253 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 226900009254 GTP/Mg2+ binding site [chemical binding]; other site 226900009255 G4 box; other site 226900009256 G5 box; other site 226900009257 G1 box; other site 226900009258 Switch I region; other site 226900009259 G2 box; other site 226900009260 G3 box; other site 226900009261 Switch II region; other site 226900009262 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900009263 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900009264 Catalytic site [active] 226900009265 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 226900009266 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 226900009267 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 226900009268 RimM N-terminal domain; Region: RimM; pfam01782 226900009269 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 226900009270 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 226900009271 hypothetical protein; Provisional; Region: PRK00468; cl00794 226900009272 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 226900009273 signal recognition particle protein; Provisional; Region: PRK10867 226900009274 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 226900009275 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226900009276 P loop; other site 226900009277 GTP binding site [chemical binding]; other site 226900009278 Signal peptide binding domain; Region: SRP_SPB; pfam02978 226900009279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 226900009280 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 226900009281 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 226900009282 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 226900009283 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226900009284 P loop; other site 226900009285 GTP binding site [chemical binding]; other site 226900009286 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226900009287 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 226900009288 Walker A/P-loop; other site 226900009289 ATP binding site [chemical binding]; other site 226900009290 Q-loop/lid; other site 226900009291 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 226900009292 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 226900009293 ABC transporter signature motif; other site 226900009294 Walker B; other site 226900009295 D-loop; other site 226900009296 H-loop/switch region; other site 226900009297 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 226900009298 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226900009299 dimerization interface [polypeptide binding]; other site 226900009300 active site 226900009301 metal binding site [ion binding]; metal-binding site 226900009302 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 226900009303 dsRNA binding site [nucleotide binding]; other site 226900009304 Phosphopantetheine attachment site; Region: PP-binding; cl09936 226900009305 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900009306 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226900009307 NAD(P) binding site [chemical binding]; other site 226900009308 homotetramer interface [polypeptide binding]; other site 226900009309 homodimer interface [polypeptide binding]; other site 226900009310 active site 226900009311 Acyl transferase domain; Region: Acyl_transf_1; cl08282 226900009312 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 226900009313 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 226900009314 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 226900009315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226900009316 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 226900009317 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 226900009318 generic binding surface II; other site 226900009319 ssDNA binding site; other site 226900009320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900009321 ATP binding site [chemical binding]; other site 226900009322 putative Mg++ binding site [ion binding]; other site 226900009323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900009324 nucleotide binding region [chemical binding]; other site 226900009325 ATP-binding site [chemical binding]; other site 226900009326 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 226900009327 DAK2 domain; Region: Dak2; cl03685 226900009328 Protein of unknown function (DUF322); Region: DUF322; cl00574 226900009329 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 226900009330 Thiamine pyrophosphokinase; Region: TPK; cd07995 226900009331 active site 226900009332 dimerization interface [polypeptide binding]; other site 226900009333 thiamine binding site [chemical binding]; other site 226900009334 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 226900009335 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 226900009336 substrate binding site [chemical binding]; other site 226900009337 hexamer interface [polypeptide binding]; other site 226900009338 metal binding site [ion binding]; metal-binding site 226900009339 GTPase RsgA; Reviewed; Region: PRK00098 226900009340 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 226900009341 GTPase/OB domain interface [polypeptide binding]; other site 226900009342 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226900009343 GTP/Mg2+ binding site [chemical binding]; other site 226900009344 G4 box; other site 226900009345 G5 box; other site 226900009346 G1 box; other site 226900009347 Switch I region; other site 226900009348 G2 box; other site 226900009349 G3 box; other site 226900009350 Switch II region; other site 226900009351 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226900009352 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226900009353 active site 226900009354 ATP binding site [chemical binding]; other site 226900009355 substrate binding site [chemical binding]; other site 226900009356 activation loop (A-loop); other site 226900009357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 226900009358 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226900009359 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 226900009360 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226900009361 Protein phosphatase 2C; Region: PP2C; pfam00481 226900009362 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 226900009363 active site 226900009364 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 226900009365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900009366 FeS/SAM binding site; other site 226900009367 16S rRNA methyltransferase B; Provisional; Region: PRK14902 226900009368 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 226900009369 putative RNA binding site [nucleotide binding]; other site 226900009370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900009371 S-adenosylmethionine binding site [chemical binding]; other site 226900009372 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 226900009373 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 226900009374 putative active site [active] 226900009375 substrate binding site [chemical binding]; other site 226900009376 putative cosubstrate binding site; other site 226900009377 catalytic site [active] 226900009378 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 226900009379 substrate binding site [chemical binding]; other site 226900009380 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226900009381 active site 226900009382 catalytic residues [active] 226900009383 metal binding site [ion binding]; metal-binding site 226900009384 primosome assembly protein PriA; Validated; Region: PRK05580 226900009385 primosome assembly protein PriA; Validated; Region: PRK05580 226900009386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900009387 ATP binding site [chemical binding]; other site 226900009388 putative Mg++ binding site [ion binding]; other site 226900009389 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900009390 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 226900009391 Flavoprotein; Region: Flavoprotein; cl08021 226900009392 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 226900009393 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 226900009394 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 226900009395 catalytic site [active] 226900009396 G-X2-G-X-G-K; other site 226900009397 Domain of unknown function (DUF370); Region: DUF370; cl00898 226900009398 hypothetical protein; Provisional; Region: PRK11820 226900009399 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 226900009400 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 226900009401 similar to calcium-transporting ATPase; EC_number 3.6.3.8 226900009402 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 226900009403 Domain of unknown function (DUF814); Region: DUF814; pfam05670 226900009404 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 226900009405 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900009406 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900009407 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900009408 active site 226900009409 DinB superfamily; Region: DinB_2; cl00986 226900009410 YoqO-like protein; Region: YoqO; pfam14037 226900009411 YoqO-like protein; Region: YoqO; pfam14037 226900009412 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 226900009413 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 226900009414 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009415 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900009416 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 226900009417 active site 226900009418 dimer interface [polypeptide binding]; other site 226900009419 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 226900009420 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 226900009421 heterodimer interface [polypeptide binding]; other site 226900009422 active site 226900009423 FMN binding site [chemical binding]; other site 226900009424 homodimer interface [polypeptide binding]; other site 226900009425 substrate binding site [chemical binding]; other site 226900009426 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 226900009427 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 226900009428 FAD binding pocket [chemical binding]; other site 226900009429 FAD binding motif [chemical binding]; other site 226900009430 phosphate binding motif [ion binding]; other site 226900009431 beta-alpha-beta structure motif; other site 226900009432 NAD binding pocket [chemical binding]; other site 226900009433 Iron coordination center [ion binding]; other site 226900009434 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 226900009435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900009436 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900009437 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900009438 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900009439 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 226900009440 IMP binding site; other site 226900009441 dimer interface [polypeptide binding]; other site 226900009442 interdomain contacts; other site 226900009443 partial ornithine binding site; other site 226900009444 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 226900009445 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 226900009446 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 226900009447 catalytic site [active] 226900009448 subunit interface [polypeptide binding]; other site 226900009449 dihydroorotase; Validated; Region: pyrC; PRK09357 226900009450 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226900009451 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 226900009452 active site 226900009453 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 226900009454 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900009455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009456 Permease family; Region: Xan_ur_permease; cl00967 226900009457 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900009458 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 226900009459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900009460 RNA binding surface [nucleotide binding]; other site 226900009461 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 226900009462 active site 226900009463 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 226900009464 lipoprotein signal peptidase; Provisional; Region: PRK14787 226900009465 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 226900009466 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 226900009467 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226900009468 active site 226900009469 HIGH motif; other site 226900009470 nucleotide binding site [chemical binding]; other site 226900009471 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226900009472 active site 226900009473 KMSKS motif; other site 226900009474 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 226900009475 tRNA binding surface [nucleotide binding]; other site 226900009476 anticodon binding site; other site 226900009477 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226900009478 DivIVA protein; Region: DivIVA; pfam05103 226900009479 DivIVA domain; Region: DivI1A_domain; TIGR03544 226900009480 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 226900009481 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 226900009482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900009483 RNA binding surface [nucleotide binding]; other site 226900009484 YGGT family; Region: YGGT; cl00508 226900009485 Protein of unknown function (DUF552); Region: DUF552; cl00775 226900009486 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 226900009487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900009488 catalytic residue [active] 226900009489 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 226900009490 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 226900009491 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 226900009492 sporulation sigma factor SigG; Reviewed; Region: PRK08215 226900009493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900009494 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900009495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900009496 DNA binding residues [nucleotide binding] 226900009497 sporulation sigma factor SigE; Reviewed; Region: PRK08301 226900009498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900009499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900009500 DNA binding residues [nucleotide binding] 226900009501 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 226900009502 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 226900009503 cell division protein FtsZ; Validated; Region: PRK09330 226900009504 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 226900009505 nucleotide binding site [chemical binding]; other site 226900009506 SulA interaction site; other site 226900009507 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 226900009508 Cell division protein FtsA; Region: FtsA; cl11496 226900009509 Cell division protein FtsA; Region: FtsA; cl11496 226900009510 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 226900009511 Cell division protein FtsQ; Region: FtsQ; pfam03799 226900009512 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 226900009513 FAD binding domain; Region: FAD_binding_4; pfam01565 226900009514 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226900009515 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 226900009516 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900009517 active site 226900009518 homodimer interface [polypeptide binding]; other site 226900009519 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900009520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009521 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 226900009522 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 226900009523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900009524 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 226900009525 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 226900009526 Mg++ binding site [ion binding]; other site 226900009527 putative catalytic motif [active] 226900009528 putative substrate binding site [chemical binding]; other site 226900009529 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 226900009530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900009531 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 226900009532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900009533 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 226900009534 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900009535 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900009536 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 226900009537 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 226900009538 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900009539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900009540 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 226900009541 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226900009542 Septum formation initiator; Region: DivIC; cl11433 226900009543 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 226900009544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900009545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 226900009546 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 226900009547 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 226900009548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009549 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226900009550 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900009551 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 226900009552 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 226900009553 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 226900009554 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 226900009555 similar to hypothetical Cytosolic Protein 226900009556 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 226900009557 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 226900009558 protein binding site [polypeptide binding]; other site 226900009559 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900009560 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226900009561 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 226900009562 active site 226900009563 nucleophile elbow; other site 226900009564 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 226900009565 Nucleoside recognition; Region: Gate; cl00486 226900009566 Nucleoside recognition; Region: Gate; cl00486 226900009567 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 226900009568 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 226900009569 active site 226900009570 (T/H)XGH motif; other site 226900009571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900009572 S-adenosylmethionine binding site [chemical binding]; other site 226900009573 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 226900009574 Protein of unknown function (DUF964); Region: DUF964; cl01483 226900009575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900009576 catalytic core [active] 226900009577 YlbE-like protein; Region: YlbE; pfam14003 226900009578 Putative coat protein; Region: YlbD_coat; pfam14071 226900009579 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 226900009580 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 226900009581 YugN-like family; Region: YugN; pfam08868 226900009582 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 226900009583 multimer interface [polypeptide binding]; other site 226900009584 active site 226900009585 catalytic triad [active] 226900009586 dimer interface [polypeptide binding]; other site 226900009587 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 226900009588 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 226900009589 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 226900009590 Subunit I/III interface [polypeptide binding]; other site 226900009591 Subunit III/IV interface [polypeptide binding]; other site 226900009592 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 226900009593 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 226900009594 D-pathway; other site 226900009595 Putative ubiquinol binding site [chemical binding]; other site 226900009596 Low-spin heme (heme b) binding site [chemical binding]; other site 226900009597 Putative water exit pathway; other site 226900009598 Binuclear center (heme o3/CuB) [ion binding]; other site 226900009599 K-pathway; other site 226900009600 Putative proton exit pathway; other site 226900009601 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 226900009602 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 226900009603 Cytochrome c; Region: Cytochrom_C; cl11414 226900009604 UbiA prenyltransferase family; Region: UbiA; cl00337 226900009605 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 226900009606 pyruvate carboxylase; Reviewed; Region: PRK12999 226900009607 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900009608 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900009609 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 226900009610 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 226900009611 active site 226900009612 catalytic residues [active] 226900009613 metal binding site [ion binding]; metal-binding site 226900009614 homodimer binding site [polypeptide binding]; other site 226900009615 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226900009616 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900009617 carboxyltransferase (CT) interaction site; other site 226900009618 biotinylation site [posttranslational modification]; other site 226900009619 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900009620 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 226900009621 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 226900009622 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 226900009623 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 226900009624 putative active site [active] 226900009625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900009626 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 226900009627 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 226900009628 YlaH-like protein; Region: YlaH; pfam14036 226900009629 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 226900009630 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 226900009631 G1 box; other site 226900009632 putative GEF interaction site [polypeptide binding]; other site 226900009633 GTP/Mg2+ binding site [chemical binding]; other site 226900009634 Switch I region; other site 226900009635 G2 box; other site 226900009636 G3 box; other site 226900009637 Switch II region; other site 226900009638 G4 box; other site 226900009639 G5 box; other site 226900009640 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 226900009641 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 226900009642 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 226900009643 active site 226900009644 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 226900009645 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 226900009646 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 226900009647 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 226900009648 homodimer interface [polypeptide binding]; other site 226900009649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900009650 catalytic residue [active] 226900009651 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 226900009652 transglutaminase; Provisional; Region: tgl; PRK03187 226900009653 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 226900009654 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 226900009655 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 226900009656 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 226900009657 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 226900009658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 226900009660 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900009661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900009662 E3 interaction surface; other site 226900009663 lipoyl attachment site [posttranslational modification]; other site 226900009664 e3 binding domain; Region: E3_binding; pfam02817 226900009665 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 226900009666 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900009667 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900009668 alpha subunit interface [polypeptide binding]; other site 226900009669 TPP binding site [chemical binding]; other site 226900009670 heterodimer interface [polypeptide binding]; other site 226900009671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900009672 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 226900009673 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900009674 TPP-binding site [chemical binding]; other site 226900009675 heterodimer interface [polypeptide binding]; other site 226900009676 tetramer interface [polypeptide binding]; other site 226900009677 phosphorylation loop region [posttranslational modification] 226900009678 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226900009679 active site 226900009680 catalytic residues [active] 226900009681 metal binding site [ion binding]; metal-binding site 226900009682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900009683 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900009684 active site 226900009685 motif I; other site 226900009686 motif II; other site 226900009687 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009688 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 226900009689 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900009690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900009691 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 226900009692 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900009693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009694 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900009695 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900009696 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900009697 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 226900009698 metal binding site [ion binding]; metal-binding site 226900009699 putative dimer interface [polypeptide binding]; other site 226900009700 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 226900009701 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 226900009702 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 226900009703 trimer interface [polypeptide binding]; other site 226900009704 active site 226900009705 substrate binding site [chemical binding]; other site 226900009706 CoA binding site [chemical binding]; other site 226900009707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900009708 Helix-turn-helix domains; Region: HTH; cl00088 226900009709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900009710 dimerization interface [polypeptide binding]; other site 226900009711 FOG: CBS domain [General function prediction only]; Region: COG0517 226900009712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 226900009713 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 226900009714 Protein of unknown function (DUF458); Region: DUF458; cl00861 226900009715 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 226900009716 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 226900009717 catalytic residues [active] 226900009718 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 226900009719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900009720 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 226900009721 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 226900009722 short chain dehydrogenase; Provisional; Region: PRK07677 226900009723 NAD(P) binding site [chemical binding]; other site 226900009724 substrate binding site [chemical binding]; other site 226900009725 homotetramer interface [polypeptide binding]; other site 226900009726 active site 226900009727 homodimer interface [polypeptide binding]; other site 226900009728 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900009729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900009730 putative active site [active] 226900009731 putative metal binding site [ion binding]; other site 226900009732 Polyphosphate kinase; Region: PP_kinase; pfam02503 226900009733 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 226900009734 putative domain interface [polypeptide binding]; other site 226900009735 putative active site [active] 226900009736 catalytic site [active] 226900009737 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 226900009738 putative domain interface [polypeptide binding]; other site 226900009739 putative active site [active] 226900009740 catalytic site [active] 226900009741 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 226900009742 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 226900009743 YkyB-like protein; Region: YkyB; pfam14177 226900009744 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 226900009745 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900009746 Phage lysis protein, holin; Region: Phage_holin; cl04675 226900009747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900009748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900009749 putative substrate translocation pore; other site 226900009750 Helix-turn-helix domains; Region: HTH; cl00088 226900009751 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 226900009752 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 226900009753 THF binding site; other site 226900009754 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 226900009755 substrate binding site [chemical binding]; other site 226900009756 THF binding site; other site 226900009757 zinc-binding site [ion binding]; other site 226900009758 Competence protein J (ComJ); Region: ComJ; pfam11033 226900009759 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 226900009760 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 226900009761 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 226900009762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900009763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900009764 dimer interface [polypeptide binding]; other site 226900009765 phosphorylation site [posttranslational modification] 226900009766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900009767 ATP binding site [chemical binding]; other site 226900009768 Mg2+ binding site [ion binding]; other site 226900009769 G-X-G motif; other site 226900009770 aminotransferase A; Validated; Region: PRK07683 226900009771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900009772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900009773 homodimer interface [polypeptide binding]; other site 226900009774 catalytic residue [active] 226900009775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900009776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900009777 DNA binding site [nucleotide binding] 226900009778 domain linker motif; other site 226900009779 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 226900009780 putative dimerization interface [polypeptide binding]; other site 226900009781 putative ligand binding site [chemical binding]; other site 226900009782 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 226900009783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900009784 dimer interface [polypeptide binding]; other site 226900009785 conserved gate region; other site 226900009786 putative PBP binding loops; other site 226900009787 ABC-ATPase subunit interface; other site 226900009788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900009789 dimer interface [polypeptide binding]; other site 226900009790 conserved gate region; other site 226900009791 putative PBP binding loops; other site 226900009792 ABC-ATPase subunit interface; other site 226900009793 similar to Cyclodextrin-binding protein 226900009794 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 226900009795 homodimer interface [polypeptide binding]; other site 226900009796 maltodextrin glucosidase; Provisional; Region: PRK10785 226900009797 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 226900009798 active site 226900009799 homodimer interface [polypeptide binding]; other site 226900009800 catalytic site [active] 226900009801 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900009802 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900009803 Ca binding site [ion binding]; other site 226900009804 active site 226900009805 catalytic site [active] 226900009806 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 226900009807 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 226900009808 Walker A/P-loop; other site 226900009809 ATP binding site [chemical binding]; other site 226900009810 Q-loop/lid; other site 226900009811 ABC transporter signature motif; other site 226900009812 Walker B; other site 226900009813 D-loop; other site 226900009814 H-loop/switch region; other site 226900009815 TOBE domain; Region: TOBE_2; cl01440 226900009816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009817 NAD(P) binding site [chemical binding]; other site 226900009818 RDD family; Region: RDD; cl00746 226900009819 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 226900009820 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 226900009821 Predicted ATPase [General function prediction only]; Region: COG3910 226900009822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900009823 Walker A/P-loop; other site 226900009824 ATP binding site [chemical binding]; other site 226900009825 Q-loop/lid; other site 226900009826 ABC transporter signature motif; other site 226900009827 Walker B; other site 226900009828 D-loop; other site 226900009829 H-loop/switch region; other site 226900009830 putative acyltransferase; Provisional; Region: PRK05790 226900009831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900009832 dimer interface [polypeptide binding]; other site 226900009833 active site 226900009834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900009835 nudix motif; other site 226900009836 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 226900009837 hypothetical protein; Validated; Region: PRK07668 226900009838 hypothetical protein; Validated; Region: PRK07668 226900009839 Helix-turn-helix domains; Region: HTH; cl00088 226900009840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009841 NAD(P) binding site [chemical binding]; other site 226900009842 active site 226900009843 YvrJ protein family; Region: YvrJ; pfam12841 226900009844 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 226900009845 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 226900009846 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900009847 Predicted amidohydrolase [General function prediction only]; Region: COG0388 226900009848 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 226900009849 putative active site [active] 226900009850 catalytic triad [active] 226900009851 putative dimer interface [polypeptide binding]; other site 226900009852 transaminase; Reviewed; Region: PRK08068 226900009853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900009854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900009855 homodimer interface [polypeptide binding]; other site 226900009856 catalytic residue [active] 226900009857 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 226900009858 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 226900009859 dimer interface [polypeptide binding]; other site 226900009860 active site 226900009861 catalytic residue [active] 226900009862 metal binding site [ion binding]; metal-binding site 226900009863 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009864 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226900009865 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 226900009866 intersubunit interface [polypeptide binding]; other site 226900009867 active site 226900009868 Zn2+ binding site [ion binding]; other site 226900009869 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 226900009870 Cupin domain; Region: Cupin_2; cl09118 226900009871 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 226900009872 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 226900009873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009874 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900009875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900009876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900009877 metal binding site [ion binding]; metal-binding site 226900009878 active site 226900009879 I-site; other site 226900009880 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900009881 dimer interface [polypeptide binding]; other site 226900009882 FMN binding site [chemical binding]; other site 226900009883 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 226900009884 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 226900009885 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 226900009886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 226900009887 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 226900009888 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 226900009889 dimerization domain swap beta strand [polypeptide binding]; other site 226900009890 regulatory protein interface [polypeptide binding]; other site 226900009891 active site 226900009892 regulatory phosphorylation site [posttranslational modification]; other site 226900009893 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900009894 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 226900009895 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900009896 active site turn [active] 226900009897 phosphorylation site [posttranslational modification] 226900009898 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 226900009899 HPr interaction site; other site 226900009900 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226900009901 active site 226900009902 phosphorylation site [posttranslational modification] 226900009903 transcriptional antiterminator BglG; Provisional; Region: PRK09772 226900009904 CAT RNA binding domain; Region: CAT_RBD; cl03904 226900009905 PRD domain; Region: PRD; cl15445 226900009906 PRD domain; Region: PRD; cl15445 226900009907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900009908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900009909 active site 226900009910 motif I; other site 226900009911 motif II; other site 226900009912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900009913 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900009914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900009915 DNA-binding site [nucleotide binding]; DNA binding site 226900009916 UTRA domain; Region: UTRA; cl01230 226900009917 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226900009918 active site 226900009919 trimer interface [polypeptide binding]; other site 226900009920 allosteric site; other site 226900009921 active site lid [active] 226900009922 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226900009923 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226900009924 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 226900009925 active site 226900009926 dimer interface [polypeptide binding]; other site 226900009927 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900009928 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 226900009929 ScpA/B protein; Region: ScpA_ScpB; cl00598 226900009930 Domain of unknown function (DUF309); Region: DUF309; cl00667 226900009931 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900009932 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 226900009933 active site 226900009934 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 226900009935 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009936 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900009937 active site 226900009938 motif I; other site 226900009939 motif II; other site 226900009940 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009941 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900009942 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900009943 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 226900009944 SpoVA protein; Region: SpoVA; cl04298 226900009945 stage V sporulation protein AD; Validated; Region: PRK08304 226900009946 stage V sporulation protein AD; Provisional; Region: PRK12404 226900009947 SpoVA protein; Region: SpoVA; cl04298 226900009948 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 226900009949 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 226900009950 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 226900009951 sporulation sigma factor SigF; Validated; Region: PRK05572 226900009952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900009953 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900009954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900009955 DNA binding residues [nucleotide binding] 226900009956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900009957 ATP binding site [chemical binding]; other site 226900009958 Mg2+ binding site [ion binding]; other site 226900009959 G-X-G motif; other site 226900009960 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 226900009961 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900009962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900009963 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900009964 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900009965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900009966 DNA-binding site [nucleotide binding]; DNA binding site 226900009967 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900009968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900009969 Walker A/P-loop; other site 226900009970 ATP binding site [chemical binding]; other site 226900009971 Q-loop/lid; other site 226900009972 ABC transporter signature motif; other site 226900009973 Walker B; other site 226900009974 D-loop; other site 226900009975 H-loop/switch region; other site 226900009976 Helix-turn-helix domains; Region: HTH; cl00088 226900009977 Protein of unknown function (DUF541); Region: SIMPL; cl01077 226900009978 Permease family; Region: Xan_ur_permease; cl00967 226900009979 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 226900009980 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 226900009981 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 226900009982 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 226900009983 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900009984 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900009985 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 226900009986 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 226900009987 Sulfatase; Region: Sulfatase; cl10460 226900009988 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 226900009989 FixH; Region: FixH; cl01254 226900009990 FixH; Region: FixH; cl01254 226900009991 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226900009992 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226900009993 Int/Topo IB signature motif; other site 226900009994 active site 226900009995 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 226900009996 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900009997 metal binding site 2 [ion binding]; metal-binding site 226900009998 putative DNA binding helix; other site 226900009999 metal binding site 1 [ion binding]; metal-binding site 226900010000 dimer interface [polypeptide binding]; other site 226900010001 structural Zn2+ binding site [ion binding]; other site 226900010002 Integral membrane protein DUF95; Region: DUF95; cl00572 226900010003 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900010004 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900010005 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 226900010006 dimer interface [polypeptide binding]; other site 226900010007 ADP-ribose binding site [chemical binding]; other site 226900010008 active site 226900010009 nudix motif; other site 226900010010 metal binding site [ion binding]; metal-binding site 226900010011 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 226900010012 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900010013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900010014 active site 226900010015 catalytic tetrad [active] 226900010016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900010017 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900010018 active site 226900010019 catalytic tetrad [active] 226900010020 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 226900010021 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900010022 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 226900010023 putative active site [active] 226900010024 putative metal binding site [ion binding]; other site 226900010025 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900010026 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 226900010027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900010028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900010029 Predicted permease [General function prediction only]; Region: COG2056 226900010030 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 226900010031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900010032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900010033 DNA binding site [nucleotide binding] 226900010034 domain linker motif; other site 226900010035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226900010036 dimerization interface [polypeptide binding]; other site 226900010037 ligand binding site [chemical binding]; other site 226900010038 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900010039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900010040 Coenzyme A binding pocket [chemical binding]; other site 226900010041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900010042 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 226900010043 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 226900010044 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 226900010045 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 226900010046 catalytic motif [active] 226900010047 Zn binding site [ion binding]; other site 226900010048 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 226900010049 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 226900010050 Lumazine binding domain; Region: Lum_binding; pfam00677 226900010051 Lumazine binding domain; Region: Lum_binding; pfam00677 226900010052 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 226900010053 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 226900010054 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 226900010055 dimerization interface [polypeptide binding]; other site 226900010056 active site 226900010057 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 226900010058 homopentamer interface [polypeptide binding]; other site 226900010059 active site 226900010060 biotin synthase; Validated; Region: PRK06256 226900010061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010062 FeS/SAM binding site; other site 226900010063 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 226900010064 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 226900010065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010066 S-adenosylmethionine binding site [chemical binding]; other site 226900010067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900010068 Protein of unknown function (DUF452); Region: DUF452; cl01062 226900010069 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 226900010070 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226900010071 substrate-cofactor binding pocket; other site 226900010072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010073 catalytic residue [active] 226900010074 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226900010075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900010076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900010077 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 226900010078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900010079 inhibitor-cofactor binding pocket; inhibition site 226900010080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010081 catalytic residue [active] 226900010082 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900010083 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; EC_number 3.1.4.16 226900010084 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 226900010085 active site 226900010086 catalytic triad [active] 226900010087 oxyanion hole [active] 226900010088 Helix-turn-helix domains; Region: HTH; cl00088 226900010089 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 226900010090 ornithine carbamoyltransferase; Provisional; Region: PRK00779 226900010091 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900010092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010093 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 226900010094 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900010095 inhibitor-cofactor binding pocket; inhibition site 226900010096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010097 catalytic residue [active] 226900010098 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 226900010099 nucleotide binding site [chemical binding]; other site 226900010100 N-acetyl-L-glutamate binding site [chemical binding]; other site 226900010101 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 226900010102 heterotetramer interface [polypeptide binding]; other site 226900010103 active site pocket [active] 226900010104 cleavage site 226900010105 similar to N-acetyl-gamma-glutamyl-phosphate reductase; EC_number 1.2.1.38 226900010106 YqzH-like protein; Region: YqzH; pfam14164 226900010107 similar to Ketoacyl reductase hetN; EC_number 1.3.1.- 226900010108 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900010109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010110 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 226900010111 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 226900010112 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 226900010113 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 226900010114 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 226900010115 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 226900010116 putative L-serine binding site [chemical binding]; other site 226900010117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900010118 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 226900010119 magnesium-transporting ATPase; Provisional; Region: PRK15122 226900010120 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 226900010121 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900010122 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900010123 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226900010124 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226900010125 MgtC family; Region: MgtC; cl12207 226900010126 DNA polymerase IV; Validated; Region: PRK01810 226900010127 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 226900010128 active site 226900010129 DNA binding site [nucleotide binding] 226900010130 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 226900010131 peptidase T-like protein; Region: PepT-like; TIGR01883 226900010132 metal binding site [ion binding]; metal-binding site 226900010133 putative dimer interface [polypeptide binding]; other site 226900010134 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900010135 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900010136 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 226900010137 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 226900010138 Predicted membrane protein [Function unknown]; Region: COG4129 226900010139 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 226900010140 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 226900010141 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900010142 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 226900010143 Walker A/P-loop; other site 226900010144 ATP binding site [chemical binding]; other site 226900010145 Q-loop/lid; other site 226900010146 ABC transporter signature motif; other site 226900010147 Walker B; other site 226900010148 D-loop; other site 226900010149 H-loop/switch region; other site 226900010150 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 226900010151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010152 dimer interface [polypeptide binding]; other site 226900010153 conserved gate region; other site 226900010154 putative PBP binding loops; other site 226900010155 ABC-ATPase subunit interface; other site 226900010156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226900010157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900010158 substrate binding pocket [chemical binding]; other site 226900010159 membrane-bound complex binding site; other site 226900010160 hinge residues; other site 226900010161 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 226900010162 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 226900010163 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900010164 nudix motif; other site 226900010165 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900010166 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900010167 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900010168 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900010169 E3 interaction surface; other site 226900010170 lipoyl attachment site [posttranslational modification]; other site 226900010171 e3 binding domain; Region: E3_binding; pfam02817 226900010172 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 226900010173 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900010174 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900010175 alpha subunit interface [polypeptide binding]; other site 226900010176 TPP binding site [chemical binding]; other site 226900010177 heterodimer interface [polypeptide binding]; other site 226900010178 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900010179 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 226900010180 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900010181 tetramer interface [polypeptide binding]; other site 226900010182 TPP-binding site [chemical binding]; other site 226900010183 heterodimer interface [polypeptide binding]; other site 226900010184 phosphorylation loop region [posttranslational modification] 226900010185 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 226900010186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 226900010189 Acetokinase family; Region: Acetate_kinase; cl01029 226900010190 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 226900010191 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 226900010192 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 226900010193 NAD binding site [chemical binding]; other site 226900010194 Phe binding site; other site 226900010195 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 226900010196 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 226900010197 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 226900010198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900010199 putative active site [active] 226900010200 heme pocket [chemical binding]; other site 226900010201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900010202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900010203 Walker A motif; other site 226900010204 ATP binding site [chemical binding]; other site 226900010205 Walker B motif; other site 226900010206 arginine finger; other site 226900010207 Helix-turn-helix domains; Region: HTH; cl00088 226900010208 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 226900010209 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 226900010210 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 226900010211 active site 226900010212 catalytic site [active] 226900010213 metal binding site [ion binding]; metal-binding site 226900010214 dimer interface [polypeptide binding]; other site 226900010215 YycC-like protein; Region: YycC; pfam14174 226900010216 hypothetical protein; Provisional; Region: PRK06770 226900010217 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 226900010218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900010219 active site 226900010220 phosphorylation site [posttranslational modification] 226900010221 intermolecular recognition site; other site 226900010222 dimerization interface [polypeptide binding]; other site 226900010223 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 226900010224 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 226900010225 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 226900010226 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 226900010227 similar to DNA repair protein recN 226900010228 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226900010229 arginine repressor; Provisional; Region: PRK04280 226900010230 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226900010231 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 226900010232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900010233 RNA binding surface [nucleotide binding]; other site 226900010234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900010235 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 226900010236 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 226900010237 TPP-binding site; other site 226900010238 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226900010239 PYR/PP interface [polypeptide binding]; other site 226900010240 dimer interface [polypeptide binding]; other site 226900010241 TPP binding site [chemical binding]; other site 226900010242 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900010243 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226900010244 substrate binding pocket [chemical binding]; other site 226900010245 chain length determination region; other site 226900010246 substrate-Mg2+ binding site; other site 226900010247 catalytic residues [active] 226900010248 aspartate-rich region 1; other site 226900010249 active site lid residues [active] 226900010250 aspartate-rich region 2; other site 226900010251 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 226900010252 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 226900010253 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 226900010254 generic binding surface II; other site 226900010255 generic binding surface I; other site 226900010256 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 226900010257 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 226900010258 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 226900010259 homodimer interface [polypeptide binding]; other site 226900010260 NADP binding site [chemical binding]; other site 226900010261 substrate binding site [chemical binding]; other site 226900010262 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 226900010263 putative RNA binding site [nucleotide binding]; other site 226900010264 Protein of unknown function (DUF322); Region: DUF322; cl00574 226900010265 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 226900010266 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900010267 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900010268 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 226900010269 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 226900010270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900010271 carboxyltransferase (CT) interaction site; other site 226900010272 biotinylation site [posttranslational modification]; other site 226900010273 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 226900010274 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 226900010275 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 226900010276 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 226900010277 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 226900010278 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 226900010279 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 226900010280 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 226900010281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900010282 Walker A motif; other site 226900010283 ATP binding site [chemical binding]; other site 226900010284 Walker B motif; other site 226900010285 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 226900010286 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900010287 elongation factor P; Validated; Region: PRK00529 226900010288 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 226900010289 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 226900010290 RNA binding site [nucleotide binding]; other site 226900010291 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 226900010292 RNA binding site [nucleotide binding]; other site 226900010293 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900010294 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900010295 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900010296 active site 226900010297 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 226900010298 trimer interface [polypeptide binding]; other site 226900010299 active site 226900010300 dimer interface [polypeptide binding]; other site 226900010301 Conserved membrane protein YqhR; Region: YqhR; pfam11085 226900010302 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 226900010303 Carbon starvation protein CstA; Region: CstA; cl00856 226900010304 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226900010305 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900010306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010307 motif II; other site 226900010308 manganese transport transcriptional regulator; Provisional; Region: PRK03902 226900010309 Helix-turn-helix domains; Region: HTH; cl00088 226900010310 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 226900010311 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 226900010312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010313 FeS/SAM binding site; other site 226900010314 Helix-turn-helix domains; Region: HTH; cl00088 226900010315 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226900010316 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 226900010317 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900010318 active site residue [active] 226900010319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900010320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900010321 DNA binding site [nucleotide binding] 226900010322 domain linker motif; other site 226900010323 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900010324 putative dimerization interface [polypeptide binding]; other site 226900010325 putative ligand binding site [chemical binding]; other site 226900010326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900010327 Helix-turn-helix domains; Region: HTH; cl00088 226900010328 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226900010329 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 226900010330 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 226900010331 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900010332 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900010333 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900010334 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900010335 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900010336 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900010337 Walker A/P-loop; other site 226900010338 ATP binding site [chemical binding]; other site 226900010339 Q-loop/lid; other site 226900010340 ABC transporter signature motif; other site 226900010341 Walker B; other site 226900010342 D-loop; other site 226900010343 H-loop/switch region; other site 226900010344 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900010345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900010346 DNA-binding site [nucleotide binding]; DNA binding site 226900010347 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 226900010348 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 226900010349 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226900010350 tetramer interface [polypeptide binding]; other site 226900010351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010352 catalytic residue [active] 226900010353 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 226900010354 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226900010355 tetramer interface [polypeptide binding]; other site 226900010356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010357 catalytic residue [active] 226900010358 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 226900010359 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 226900010360 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 226900010361 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900010362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900010363 ATP binding site [chemical binding]; other site 226900010364 putative Mg++ binding site [ion binding]; other site 226900010365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900010366 nucleotide binding region [chemical binding]; other site 226900010367 ATP-binding site [chemical binding]; other site 226900010368 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 226900010369 YqzE-like protein; Region: YqzE; pfam14038 226900010370 Shikimate kinase; Region: SKI; pfam01202 226900010371 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 226900010372 ADP binding site [chemical binding]; other site 226900010373 magnesium binding site [ion binding]; other site 226900010374 putative shikimate binding site; other site 226900010375 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 226900010376 ComG operon protein 7; Region: ComGG; pfam14173 226900010377 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 226900010378 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 226900010379 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 226900010380 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 226900010381 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 226900010382 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 226900010383 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 226900010384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900010385 Walker A motif; other site 226900010386 ATP binding site [chemical binding]; other site 226900010387 Walker B motif; other site 226900010388 Predicted transcriptional regulator [Transcription]; Region: COG2345 226900010389 Helix-turn-helix domains; Region: HTH; cl00088 226900010390 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 226900010391 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900010392 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 226900010393 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 226900010394 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 226900010395 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 226900010396 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900010397 active site 226900010398 homodimer interface [polypeptide binding]; other site 226900010399 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 226900010400 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 226900010401 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 226900010402 substrate binding pocket [chemical binding]; other site 226900010403 dimer interface [polypeptide binding]; other site 226900010404 inhibitor binding site; inhibition site 226900010405 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 226900010406 B12 binding site [chemical binding]; other site 226900010407 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 226900010408 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 226900010409 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 226900010410 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 226900010411 FAD binding site [chemical binding]; other site 226900010412 cystathionine gamma-synthase; Reviewed; Region: PRK08247 226900010413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900010414 homodimer interface [polypeptide binding]; other site 226900010415 substrate-cofactor binding pocket; other site 226900010416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010417 catalytic residue [active] 226900010418 cystathionine beta-lyase; Provisional; Region: PRK08064 226900010419 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900010420 homodimer interface [polypeptide binding]; other site 226900010421 substrate-cofactor binding pocket; other site 226900010422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010423 catalytic residue [active] 226900010424 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900010425 catalytic triad [active] 226900010426 conserved cis-peptide bond; other site 226900010427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900010428 dimerization interface [polypeptide binding]; other site 226900010429 putative DNA binding site [nucleotide binding]; other site 226900010430 putative Zn2+ binding site [ion binding]; other site 226900010431 Uncharacterized conserved protein [Function unknown]; Region: COG1565 226900010432 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 226900010433 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900010434 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 226900010435 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 226900010436 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 226900010437 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 226900010438 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 226900010439 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 226900010440 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226900010441 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 226900010442 active site 226900010443 Substrate binding site; other site 226900010444 Mg++ binding site; other site 226900010445 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226900010446 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 226900010447 active site 226900010448 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 226900010449 metal binding site [ion binding]; metal-binding site 226900010450 substrate binding site [chemical binding]; other site 226900010451 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 226900010452 PhoU domain; Region: PhoU; pfam01895 226900010453 PhoU domain; Region: PhoU; pfam01895 226900010454 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 226900010455 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 226900010456 Walker A/P-loop; other site 226900010457 ATP binding site [chemical binding]; other site 226900010458 Q-loop/lid; other site 226900010459 ABC transporter signature motif; other site 226900010460 Walker B; other site 226900010461 D-loop; other site 226900010462 H-loop/switch region; other site 226900010463 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226900010464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010465 dimer interface [polypeptide binding]; other site 226900010466 conserved gate region; other site 226900010467 putative PBP binding loops; other site 226900010468 ABC-ATPase subunit interface; other site 226900010469 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 226900010470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010471 dimer interface [polypeptide binding]; other site 226900010472 conserved gate region; other site 226900010473 putative PBP binding loops; other site 226900010474 ABC-ATPase subunit interface; other site 226900010475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900010476 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900010477 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900010478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900010479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900010480 putative substrate translocation pore; other site 226900010481 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900010482 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900010483 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900010484 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 226900010485 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 226900010486 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 226900010487 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900010488 metal binding site 2 [ion binding]; metal-binding site 226900010489 putative DNA binding helix; other site 226900010490 metal binding site 1 [ion binding]; metal-binding site 226900010491 dimer interface [polypeptide binding]; other site 226900010492 structural Zn2+ binding site [ion binding]; other site 226900010493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900010494 ABC-ATPase subunit interface; other site 226900010495 dimer interface [polypeptide binding]; other site 226900010496 putative PBP binding regions; other site 226900010497 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226900010498 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 226900010499 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900010500 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900010501 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900010502 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 226900010503 endonuclease IV; Provisional; Region: PRK01060 226900010504 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 226900010505 AP (apurinic/apyrimidinic) site pocket; other site 226900010506 DNA interaction; other site 226900010507 Metal-binding active site; metal-binding site 226900010508 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900010509 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900010510 ATP binding site [chemical binding]; other site 226900010511 Mg++ binding site [ion binding]; other site 226900010512 motif III; other site 226900010513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900010514 nucleotide binding region [chemical binding]; other site 226900010515 ATP-binding site [chemical binding]; other site 226900010516 YqfQ-like protein; Region: YqfQ; pfam14181 226900010517 similar to LytB protein 226900010518 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900010519 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900010520 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900010521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900010522 Cytochrome c; Region: Cytochrom_C; cl11414 226900010523 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 226900010524 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 226900010525 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 226900010526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900010527 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900010528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900010529 DNA binding residues [nucleotide binding] 226900010530 DNA primase; Validated; Region: dnaG; PRK05667 226900010531 CHC2 zinc finger; Region: zf-CHC2; cl15369 226900010532 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 226900010533 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 226900010534 active site 226900010535 metal binding site [ion binding]; metal-binding site 226900010536 interdomain interaction site; other site 226900010537 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 226900010538 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 226900010539 Domain of unknown function (DUF299); Region: DUF299; cl00780 226900010540 Helix-turn-helix domains; Region: HTH; cl00088 226900010541 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 226900010542 FOG: CBS domain [General function prediction only]; Region: COG0517 226900010543 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 226900010544 Recombination protein O N terminal; Region: RecO_N; pfam11967 226900010545 Recombination protein O C terminal; Region: RecO_C; pfam02565 226900010546 YqzL-like protein; Region: YqzL; pfam14006 226900010547 GTPase Era; Reviewed; Region: era; PRK00089 226900010548 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 226900010549 G1 box; other site 226900010550 GTP/Mg2+ binding site [chemical binding]; other site 226900010551 Switch I region; other site 226900010552 G2 box; other site 226900010553 Switch II region; other site 226900010554 G3 box; other site 226900010555 G4 box; other site 226900010556 G5 box; other site 226900010557 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 226900010558 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226900010559 active site 226900010560 catalytic motif [active] 226900010561 Zn binding site [ion binding]; other site 226900010562 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 226900010563 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 226900010564 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 226900010565 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 226900010566 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900010567 Zn2+ binding site [ion binding]; other site 226900010568 Mg2+ binding site [ion binding]; other site 226900010569 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 226900010570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900010571 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 226900010572 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 226900010573 YabP family; Region: YabP; cl06766 226900010574 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 226900010575 GatB domain; Region: GatB_Yqey; cl11497 226900010576 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 226900010577 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 226900010578 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226900010579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010580 FeS/SAM binding site; other site 226900010581 TRAM domain; Region: TRAM; cl01282 226900010582 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 226900010583 RNA methyltransferase, RsmE family; Region: TIGR00046 226900010584 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 226900010585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010586 S-adenosylmethionine binding site [chemical binding]; other site 226900010587 chaperone protein DnaJ; Provisional; Region: PRK14280 226900010588 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226900010589 HSP70 interaction site [polypeptide binding]; other site 226900010590 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 226900010591 substrate binding site [polypeptide binding]; other site 226900010592 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 226900010593 Zn binding sites [ion binding]; other site 226900010594 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 226900010595 dimer interface [polypeptide binding]; other site 226900010596 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 226900010597 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 226900010598 dimer interface [polypeptide binding]; other site 226900010599 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 226900010600 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 226900010601 Helix-turn-helix domains; Region: HTH; cl00088 226900010602 HrcA protein C terminal domain; Region: HrcA; pfam01628 226900010603 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 226900010604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010605 FeS/SAM binding site; other site 226900010606 HemN C-terminal region; Region: HemN_C; pfam06969 226900010607 Helix-turn-helix domains; Region: HTH; cl00088 226900010608 GTP-binding protein LepA; Provisional; Region: PRK05433 226900010609 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 226900010610 G1 box; other site 226900010611 putative GEF interaction site [polypeptide binding]; other site 226900010612 GTP/Mg2+ binding site [chemical binding]; other site 226900010613 Switch I region; other site 226900010614 G2 box; other site 226900010615 G3 box; other site 226900010616 Switch II region; other site 226900010617 G4 box; other site 226900010618 G5 box; other site 226900010619 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 226900010620 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 226900010621 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 226900010622 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 226900010623 Germination protease; Region: Peptidase_A25; cl04057 226900010624 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 226900010625 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 226900010626 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 226900010627 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 226900010628 Competence protein; Region: Competence; cl00471 226900010629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900010630 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 226900010631 catalytic motif [active] 226900010632 Zn binding site [ion binding]; other site 226900010633 SLBB domain; Region: SLBB; pfam10531 226900010634 comEA protein; Region: comE; TIGR01259 226900010635 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 226900010636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010637 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 226900010638 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 226900010639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010640 S-adenosylmethionine binding site [chemical binding]; other site 226900010641 Domain of unknown function DUF143; Region: DUF143; cl00519 226900010642 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 226900010643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900010644 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 226900010645 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 226900010646 active site 226900010647 (T/H)XGH motif; other site 226900010648 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 226900010649 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 226900010650 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 226900010651 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 226900010652 shikimate binding site; other site 226900010653 NAD(P) binding site [chemical binding]; other site 226900010654 GTPase YqeH; Provisional; Region: PRK13796 226900010655 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 226900010656 GTP/Mg2+ binding site [chemical binding]; other site 226900010657 G4 box; other site 226900010658 G5 box; other site 226900010659 G1 box; other site 226900010660 Switch I region; other site 226900010661 G2 box; other site 226900010662 G3 box; other site 226900010663 Switch II region; other site 226900010664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010665 active site 226900010666 motif I; other site 226900010667 motif II; other site 226900010668 Sporulation inhibitor A; Region: Sda; pfam08970 226900010669 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 226900010670 sporulation sigma factor SigK; Reviewed; Region: PRK05803 226900010671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900010672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900010673 DNA binding residues [nucleotide binding] 226900010674 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900010675 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 226900010676 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900010677 dimer interface [polypeptide binding]; other site 226900010678 FMN binding site [chemical binding]; other site 226900010679 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900010680 synthetase active site [active] 226900010681 NTP binding site [chemical binding]; other site 226900010682 metal binding site [ion binding]; metal-binding site 226900010683 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 226900010684 dimer interface [polypeptide binding]; other site 226900010685 Alkaline phosphatase homologues; Region: alkPPc; smart00098 226900010686 active site 226900010687 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900010688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900010689 Coenzyme A binding pocket [chemical binding]; other site 226900010690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900010691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900010692 CHAT domain; Region: CHAT; cl02083 226900010693 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 226900010694 catalytic core [active] 226900010695 translocation protein TolB; Provisional; Region: tolB; PRK04792 226900010696 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900010697 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900010698 putative active site [active] 226900010699 catalytic triad [active] 226900010700 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 226900010701 putative integrin binding motif; other site 226900010702 PA/protease domain interface [polypeptide binding]; other site 226900010703 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900010704 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 226900010705 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 226900010706 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 226900010707 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 226900010708 cofactor binding site; other site 226900010709 metal binding site [ion binding]; metal-binding site 226900010710 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 226900010711 aromatic arch; other site 226900010712 DCoH dimer interaction site [polypeptide binding]; other site 226900010713 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 226900010714 DCoH tetramer interaction site [polypeptide binding]; other site 226900010715 substrate binding site [chemical binding]; other site 226900010716 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900010717 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 226900010718 putative metal binding site [ion binding]; other site 226900010719 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900010720 active site 226900010721 metal binding site [ion binding]; metal-binding site 226900010722 DoxX; Region: DoxX; cl00976 226900010723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900010724 non-specific DNA binding site [nucleotide binding]; other site 226900010725 salt bridge; other site 226900010726 sequence-specific DNA binding site [nucleotide binding]; other site 226900010727 Cupin domain; Region: Cupin_2; cl09118 226900010728 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226900010729 active site 2 [active] 226900010730 active site 1 [active] 226900010731 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900010732 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900010733 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900010734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 226900010735 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900010736 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900010737 Walker A/P-loop; other site 226900010738 ATP binding site [chemical binding]; other site 226900010739 Q-loop/lid; other site 226900010740 ABC transporter signature motif; other site 226900010741 Walker B; other site 226900010742 D-loop; other site 226900010743 H-loop/switch region; other site 226900010744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900010745 ABC-ATPase subunit interface; other site 226900010746 dimer interface [polypeptide binding]; other site 226900010747 putative PBP binding regions; other site 226900010748 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 226900010749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226900010750 intersubunit interface [polypeptide binding]; other site 226900010751 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 226900010752 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 226900010753 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 226900010754 putative catalytic cysteine [active] 226900010755 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 226900010756 putative active site [active] 226900010757 metal binding site [ion binding]; metal-binding site 226900010758 cystathionine beta-lyase; Provisional; Region: PRK07671 226900010759 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900010760 homodimer interface [polypeptide binding]; other site 226900010761 substrate-cofactor binding pocket; other site 226900010762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010763 catalytic residue [active] 226900010764 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 226900010765 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900010766 dimer interface [polypeptide binding]; other site 226900010767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010768 catalytic residue [active] 226900010769 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 226900010770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010771 S-adenosylmethionine binding site [chemical binding]; other site 226900010772 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 226900010773 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900010774 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900010775 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 226900010776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900010777 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 226900010778 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 226900010779 domain; Region: GreA_GreB_N; pfam03449 226900010780 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 226900010781 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 226900010782 ATP-binding site [chemical binding]; other site 226900010783 Sugar specificity; other site 226900010784 Pyrimidine base specificity; other site 226900010785 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226900010786 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 226900010787 Peptidase family U32; Region: Peptidase_U32; cl03113 226900010788 Protein of unknown function (DUF556); Region: DUF556; cl00822 226900010789 Peptidase family U32; Region: Peptidase_U32; cl03113 226900010790 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 226900010791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010792 S-adenosylmethionine binding site [chemical binding]; other site 226900010793 YceG-like family; Region: YceG; pfam02618 226900010794 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 226900010795 dimerization interface [polypeptide binding]; other site 226900010796 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 226900010797 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 226900010798 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 226900010799 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 226900010800 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 226900010801 motif 1; other site 226900010802 active site 226900010803 motif 2; other site 226900010804 motif 3; other site 226900010805 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900010806 DHHA1 domain; Region: DHHA1; pfam02272 226900010807 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900010808 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900010809 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 226900010810 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 226900010811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900010812 binding surface 226900010813 TPR motif; other site 226900010814 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 226900010815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900010816 binding surface 226900010817 TPR motif; other site 226900010818 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 226900010819 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226900010820 Ligand Binding Site [chemical binding]; other site 226900010821 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900010822 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 226900010823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900010824 catalytic residue [active] 226900010825 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900010826 Helix-turn-helix domains; Region: HTH; cl00088 226900010827 recombination factor protein RarA; Reviewed; Region: PRK13342 226900010828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900010829 Walker A motif; other site 226900010830 ATP binding site [chemical binding]; other site 226900010831 Walker B motif; other site 226900010832 arginine finger; other site 226900010833 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 226900010834 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 226900010835 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 226900010836 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 226900010837 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 226900010838 putative ATP binding site [chemical binding]; other site 226900010839 putative substrate interface [chemical binding]; other site 226900010840 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 226900010841 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 226900010842 dimer interface [polypeptide binding]; other site 226900010843 anticodon binding site; other site 226900010844 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 226900010845 homodimer interface [polypeptide binding]; other site 226900010846 motif 1; other site 226900010847 active site 226900010848 motif 2; other site 226900010849 GAD domain; Region: GAD; pfam02938 226900010850 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 226900010851 motif 3; other site 226900010852 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 226900010853 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 226900010854 dimer interface [polypeptide binding]; other site 226900010855 motif 1; other site 226900010856 active site 226900010857 motif 2; other site 226900010858 motif 3; other site 226900010859 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226900010860 anticodon binding site; other site 226900010861 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 226900010862 putative active site [active] 226900010863 dimerization interface [polypeptide binding]; other site 226900010864 putative tRNAtyr binding site [nucleotide binding]; other site 226900010865 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226900010866 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900010867 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900010868 synthetase active site [active] 226900010869 NTP binding site [chemical binding]; other site 226900010870 metal binding site [ion binding]; metal-binding site 226900010871 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 226900010872 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 226900010873 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900010874 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 226900010875 DHH family; Region: DHH; pfam01368 226900010876 DHHA1 domain; Region: DHHA1; pfam02272 226900010877 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 226900010878 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226900010879 Cation efflux family; Region: Cation_efflux; cl00316 226900010880 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 226900010881 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 226900010882 Protein export membrane protein; Region: SecD_SecF; cl14618 226900010883 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 226900010884 Protein export membrane protein; Region: SecD_SecF; cl14618 226900010885 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 226900010886 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900010887 MatE; Region: MatE; cl10513 226900010888 MatE; Region: MatE; cl10513 226900010889 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900010890 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 226900010891 Preprotein translocase subunit; Region: YajC; cl00806 226900010892 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 226900010893 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 226900010894 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 226900010895 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 226900010896 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 226900010897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900010898 Walker A motif; other site 226900010899 ATP binding site [chemical binding]; other site 226900010900 Walker B motif; other site 226900010901 arginine finger; other site 226900010902 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 226900010903 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 226900010904 RuvA N terminal domain; Region: RuvA_N; pfam01330 226900010905 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 226900010906 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900010907 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900010908 putative ligand binding residues [chemical binding]; other site 226900010909 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 226900010910 BofC C-terminal domain; Region: BofC_C; pfam08955 226900010911 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900010912 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900010913 putative peptidoglycan binding site; other site 226900010914 Quinolinate synthetase A protein; Region: NadA; cl00420 226900010915 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 226900010916 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 226900010917 dimerization interface [polypeptide binding]; other site 226900010918 active site 226900010919 L-aspartate oxidase; Provisional; Region: PRK08071 226900010920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010921 domain; Region: Succ_DH_flav_C; pfam02910 226900010922 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900010923 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 226900010924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900010925 catalytic residue [active] 226900010926 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 226900010927 Helix-turn-helix domains; Region: HTH; cl00088 226900010928 3H domain; Region: 3H; pfam02829 226900010929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 226900010930 MOSC domain; Region: MOSC; pfam03473 226900010931 3-alpha domain; Region: 3-alpha; pfam03475 226900010932 prephenate dehydratase; Provisional; Region: PRK11898 226900010933 Prephenate dehydratase; Region: PDT; pfam00800 226900010934 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 226900010935 putative L-Phe binding site [chemical binding]; other site 226900010936 FtsX-like permease family; Region: FtsX; pfam02687 226900010937 FtsX-like permease family; Region: FtsX; pfam02687 226900010938 FtsX-like permease family; Region: FtsX; pfam02687 226900010939 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900010940 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900010941 Walker A/P-loop; other site 226900010942 ATP binding site [chemical binding]; other site 226900010943 Q-loop/lid; other site 226900010944 ABC transporter signature motif; other site 226900010945 Walker B; other site 226900010946 D-loop; other site 226900010947 H-loop/switch region; other site 226900010948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 226900010949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900010950 ATP binding site [chemical binding]; other site 226900010951 Mg2+ binding site [ion binding]; other site 226900010952 G-X-G motif; other site 226900010953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900010954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900010955 active site 226900010956 phosphorylation site [posttranslational modification] 226900010957 intermolecular recognition site; other site 226900010958 dimerization interface [polypeptide binding]; other site 226900010959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900010960 DNA binding site [nucleotide binding] 226900010961 GTPase CgtA; Reviewed; Region: obgE; PRK12297 226900010962 GTP1/OBG; Region: GTP1_OBG; pfam01018 226900010963 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 226900010964 G1 box; other site 226900010965 GTP/Mg2+ binding site [chemical binding]; other site 226900010966 Switch I region; other site 226900010967 G2 box; other site 226900010968 G3 box; other site 226900010969 Switch II region; other site 226900010970 G4 box; other site 226900010971 G5 box; other site 226900010972 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 226900010973 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 226900010974 Protein of unknown function (DUF464); Region: DUF464; cl01080 226900010975 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 226900010976 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 226900010977 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 226900010978 homodimer interface [polypeptide binding]; other site 226900010979 oligonucleotide binding site [chemical binding]; other site 226900010980 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 226900010981 active site 226900010982 putative substrate binding region [chemical binding]; other site 226900010983 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900010984 septum site-determining protein MinD; Region: minD_bact; TIGR01968 226900010985 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 226900010986 Switch I; other site 226900010987 Switch II; other site 226900010988 septum formation inhibitor; Reviewed; Region: minC; PRK00513 226900010989 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 226900010990 rod shape-determining protein MreD; Region: MreD; cl01087 226900010991 rod shape-determining protein MreC; Provisional; Region: PRK13922 226900010992 rod shape-determining protein MreC; Region: MreC; pfam04085 226900010993 rod shape-determining protein MreB; Provisional; Region: PRK13927 226900010994 Cell division protein FtsA; Region: FtsA; cl11496 226900010995 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226900010996 MPN+ (JAMM) motif; other site 226900010997 Zinc-binding site [ion binding]; other site 226900010998 Flp recombinase, C-terminal catalytic domain. Yeast Flp-like recombinases mediate the amplification of the 2 micron circular plasmid copy number by catalyzing the intra-molecular recombination between two inverted repeats during replication. They...; Region: INT_Flp; cd00217 226900010999 tetramerization interface [polypeptide binding]; other site 226900011000 active site 226900011001 DNA binding site [nucleotide binding] 226900011002 Int/Topo IB signature motif; other site 226900011003 catalytic residues [active] 226900011004 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 226900011005 DNA polymerase III PolC; Validated; Region: polC; PRK00448 226900011006 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900011007 DNA binding site [nucleotide binding] 226900011008 Int/Topo IB signature motif; other site 226900011009 active site 226900011010 catalytic residues [active] 226900011011 TIR domain; Region: TIR; cl02060 226900011012 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 226900011013 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 226900011014 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 226900011015 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 226900011016 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 226900011017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900011018 ATP binding site [chemical binding]; other site 226900011019 putative Mg++ binding site [ion binding]; other site 226900011020 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226900011021 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011022 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011023 HsdM N-terminal domain; Region: HsdM_N; pfam12161 226900011024 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 226900011025 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011026 hypothetical protein; Reviewed; Region: PRK00024 226900011027 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226900011028 Maf-like protein; Region: Maf; pfam02545 226900011029 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 226900011030 active site 226900011031 dimer interface [polypeptide binding]; other site 226900011032 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 226900011033 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 226900011034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900011035 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 226900011036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226900011037 active site 226900011038 HIGH motif; other site 226900011039 nucleotide binding site [chemical binding]; other site 226900011040 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 226900011041 active site 226900011042 KMSKS motif; other site 226900011043 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 226900011044 tRNA binding surface [nucleotide binding]; other site 226900011045 anticodon binding site; other site 226900011046 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 226900011047 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900011048 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 226900011049 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 226900011050 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 226900011051 putative peptidoglycan binding site; other site 226900011052 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 226900011053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900011054 inhibitor-cofactor binding pocket; inhibition site 226900011055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011056 catalytic residue [active] 226900011057 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 226900011058 dimer interface [polypeptide binding]; other site 226900011059 active site 226900011060 Schiff base residues; other site 226900011061 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 226900011062 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 226900011063 active site 226900011064 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 226900011065 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 226900011066 domain interfaces; other site 226900011067 active site 226900011068 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226900011069 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 226900011070 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 226900011071 tRNA; other site 226900011072 putative tRNA binding site [nucleotide binding]; other site 226900011073 putative NADP binding site [chemical binding]; other site 226900011074 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 226900011075 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900011076 Helix-turn-helix domains; Region: HTH; cl00088 226900011077 OsmC-like protein; Region: OsmC; cl00767 226900011078 Predicted GTPase [General function prediction only]; Region: COG0218 226900011079 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 226900011080 G1 box; other site 226900011081 GTP/Mg2+ binding site [chemical binding]; other site 226900011082 Switch I region; other site 226900011083 G2 box; other site 226900011084 G3 box; other site 226900011085 Switch II region; other site 226900011086 G4 box; other site 226900011087 G5 box; other site 226900011088 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 226900011089 Found in ATP-dependent protease La (LON); Region: LON; smart00464 226900011090 Found in ATP-dependent protease La (LON); Region: LON; smart00464 226900011091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011092 Walker A motif; other site 226900011093 ATP binding site [chemical binding]; other site 226900011094 Walker B motif; other site 226900011095 arginine finger; other site 226900011096 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900011097 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 226900011098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011099 Walker A motif; other site 226900011100 ATP binding site [chemical binding]; other site 226900011101 Walker B motif; other site 226900011102 arginine finger; other site 226900011103 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900011104 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 226900011105 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 226900011106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011107 Walker A motif; other site 226900011108 ATP binding site [chemical binding]; other site 226900011109 Walker B motif; other site 226900011110 arginine finger; other site 226900011111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 226900011112 trigger factor; Provisional; Region: tig; PRK01490 226900011113 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 226900011114 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 226900011115 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 226900011116 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 226900011117 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 226900011118 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 226900011119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900011120 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 226900011121 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 226900011122 active site 226900011123 metal binding site [ion binding]; metal-binding site 226900011124 homotetramer interface [polypeptide binding]; other site 226900011125 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 226900011126 active site 226900011127 dimerization interface [polypeptide binding]; other site 226900011128 ribonuclease PH; Reviewed; Region: rph; PRK00173 226900011129 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 226900011130 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 226900011131 Sporulation and spore germination; Region: Germane; cl11253 226900011132 Spore germination protein [General function prediction only]; Region: COG5401 226900011133 Sporulation and spore germination; Region: Germane; cl11253 226900011134 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900011135 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900011136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011137 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 226900011138 potential catalytic triad [active] 226900011139 conserved cys residue [active] 226900011140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900011141 Helix-turn-helix domains; Region: HTH; cl00088 226900011142 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 226900011143 potential catalytic triad [active] 226900011144 conserved cys residue [active] 226900011145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900011146 DNA binding residues [nucleotide binding] 226900011147 dimerization interface [polypeptide binding]; other site 226900011148 Permease family; Region: Xan_ur_permease; cl00967 226900011149 cytosine deaminase; Provisional; Region: PRK05985 226900011150 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 226900011151 active site 226900011152 PspC domain; Region: PspC; cl00864 226900011153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900011154 non-specific DNA binding site [nucleotide binding]; other site 226900011155 salt bridge; other site 226900011156 sequence-specific DNA binding site [nucleotide binding]; other site 226900011157 Cupin domain; Region: Cupin_2; cl09118 226900011158 similar to hypothetical protein 226900011159 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 226900011160 amphipathic channel; other site 226900011161 Asn-Pro-Ala signature motifs; other site 226900011162 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900011163 Helix-turn-helix domains; Region: HTH; cl00088 226900011164 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 226900011165 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 226900011166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900011167 Walker A/P-loop; other site 226900011168 ATP binding site [chemical binding]; other site 226900011169 Q-loop/lid; other site 226900011170 ABC transporter signature motif; other site 226900011171 Walker B; other site 226900011172 D-loop; other site 226900011173 H-loop/switch region; other site 226900011174 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900011175 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 226900011176 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226900011177 ligand binding site [chemical binding]; other site 226900011178 flagellar motor protein MotA; Validated; Region: PRK08124 226900011179 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 226900011180 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 226900011181 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226900011182 active site 226900011183 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 226900011184 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 226900011185 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 226900011186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900011187 domain; Region: Succ_DH_flav_C; pfam02910 226900011188 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 226900011189 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 226900011190 putative Iron-sulfur protein interface [polypeptide binding]; other site 226900011191 proximal heme binding site [chemical binding]; other site 226900011192 distal heme binding site [chemical binding]; other site 226900011193 putative dimer interface [polypeptide binding]; other site 226900011194 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 226900011195 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 226900011196 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226900011197 GIY-YIG motif/motif A; other site 226900011198 active site 226900011199 catalytic site [active] 226900011200 putative DNA binding site [nucleotide binding]; other site 226900011201 metal binding site [ion binding]; metal-binding site 226900011202 UvrB/uvrC motif; Region: UVR; pfam02151 226900011203 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 226900011204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900011205 catalytic residues [active] 226900011206 similar to Electron transfer flavoprotein alpha-subunit 226900011207 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 226900011208 Ligand binding site [chemical binding]; other site 226900011209 Electron transfer flavoprotein domain; Region: ETF; pfam01012 226900011210 enoyl-CoA hydratase; Provisional; Region: PRK07658 226900011211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900011212 substrate binding site [chemical binding]; other site 226900011213 oxyanion hole (OAH) forming residues; other site 226900011214 trimer interface [polypeptide binding]; other site 226900011215 Helix-turn-helix domains; Region: HTH; cl00088 226900011216 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 226900011217 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 226900011218 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900011219 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 226900011220 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900011221 siderophore binding site; other site 226900011222 similar to Transporter 226900011223 DinB superfamily; Region: DinB_2; cl00986 226900011224 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 226900011225 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226900011226 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226900011227 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 226900011228 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 226900011229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900011230 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 226900011231 Walker A/P-loop; other site 226900011232 ATP binding site [chemical binding]; other site 226900011233 Q-loop/lid; other site 226900011234 ABC transporter signature motif; other site 226900011235 Walker B; other site 226900011236 D-loop; other site 226900011237 H-loop/switch region; other site 226900011238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900011239 dimer interface [polypeptide binding]; other site 226900011240 phosphorylation site [posttranslational modification] 226900011241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011242 ATP binding site [chemical binding]; other site 226900011243 Mg2+ binding site [ion binding]; other site 226900011244 G-X-G motif; other site 226900011245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011247 active site 226900011248 phosphorylation site [posttranslational modification] 226900011249 intermolecular recognition site; other site 226900011250 dimerization interface [polypeptide binding]; other site 226900011251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011252 DNA binding site [nucleotide binding] 226900011253 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 226900011254 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 226900011255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900011256 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900011257 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 226900011258 active site 226900011259 catalytic site [active] 226900011260 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900011261 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900011262 Walker A/P-loop; other site 226900011263 ATP binding site [chemical binding]; other site 226900011264 Q-loop/lid; other site 226900011265 ABC transporter signature motif; other site 226900011266 Walker B; other site 226900011267 D-loop; other site 226900011268 H-loop/switch region; other site 226900011269 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 226900011270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900011271 ABC-ATPase subunit interface; other site 226900011272 dimer interface [polypeptide binding]; other site 226900011273 putative PBP binding regions; other site 226900011274 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 226900011275 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226900011276 intersubunit interface [polypeptide binding]; other site 226900011277 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011278 heme-binding site [chemical binding]; other site 226900011279 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011280 heme-binding site [chemical binding]; other site 226900011281 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011282 heme-binding site [chemical binding]; other site 226900011283 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011284 heme-binding site [chemical binding]; other site 226900011285 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011286 heme-binding site [chemical binding]; other site 226900011287 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011288 heme-binding site [chemical binding]; other site 226900011289 heme uptake protein IsdC; Region: IsdC; TIGR03656 226900011290 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900011291 heme-binding site [chemical binding]; other site 226900011292 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 226900011293 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900011294 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900011295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900011296 RNA binding surface [nucleotide binding]; other site 226900011297 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 226900011298 probable active site [active] 226900011299 similar to DNA mismatch repair protein mutS 226900011300 hypothetical protein; Provisional; Region: PRK08609 226900011301 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 226900011302 active site 226900011303 primer binding site [nucleotide binding]; other site 226900011304 NTP binding site [chemical binding]; other site 226900011305 metal binding triad [ion binding]; metal-binding site 226900011306 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 226900011307 Colicin V production protein; Region: Colicin_V; cl00567 226900011308 Cell division protein ZapA; Region: ZapA; cl01146 226900011309 ribonuclease HIII; Provisional; Region: PRK00996 226900011310 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 226900011311 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 226900011312 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900011313 active site 226900011314 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 226900011315 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 226900011316 putative dimer interface [polypeptide binding]; other site 226900011317 putative anticodon binding site; other site 226900011318 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226900011319 homodimer interface [polypeptide binding]; other site 226900011320 motif 1; other site 226900011321 motif 2; other site 226900011322 active site 226900011323 motif 3; other site 226900011324 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 226900011325 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226900011326 putative tRNA-binding site [nucleotide binding]; other site 226900011327 B3/4 domain; Region: B3_4; cl11458 226900011328 tRNA synthetase B5 domain; Region: B5; cl08394 226900011329 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 226900011330 dimer interface [polypeptide binding]; other site 226900011331 motif 1; other site 226900011332 motif 3; other site 226900011333 motif 2; other site 226900011334 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 226900011335 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 226900011336 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 226900011337 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 226900011338 dimer interface [polypeptide binding]; other site 226900011339 motif 1; other site 226900011340 active site 226900011341 motif 2; other site 226900011342 motif 3; other site 226900011343 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226900011344 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 226900011345 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 226900011346 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 226900011347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 226900011348 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900011349 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900011350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011351 putative substrate translocation pore; other site 226900011352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011353 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 226900011354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900011355 Helix-turn-helix domains; Region: HTH; cl00088 226900011356 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 226900011357 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226900011358 oligomer interface [polypeptide binding]; other site 226900011359 active site 226900011360 metal binding site [ion binding]; metal-binding site 226900011361 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 226900011362 dUTPase; Region: dUTPase_2; pfam08761 226900011363 ribosomal protein L20; Region: rpl20; CHL00068 226900011364 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 226900011365 23S rRNA binding site [nucleotide binding]; other site 226900011366 L21 binding site [polypeptide binding]; other site 226900011367 L13 binding site [polypeptide binding]; other site 226900011368 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 226900011369 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 226900011370 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 226900011371 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 226900011372 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 226900011373 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226900011374 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900011375 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226900011376 active site 226900011377 dimer interface [polypeptide binding]; other site 226900011378 motif 1; other site 226900011379 motif 2; other site 226900011380 motif 3; other site 226900011381 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226900011382 anticodon binding site; other site 226900011383 YtxC-like family; Region: YtxC; cl08500 226900011384 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 226900011385 primosomal protein DnaI; Reviewed; Region: PRK08939 226900011386 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 226900011387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011388 Walker A motif; other site 226900011389 ATP binding site [chemical binding]; other site 226900011390 Walker B motif; other site 226900011391 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 226900011392 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900011393 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 226900011394 ATP cone domain; Region: ATP-cone; pfam03477 226900011395 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 226900011396 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 226900011397 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 226900011398 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226900011399 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 226900011400 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 226900011401 CoA-binding site [chemical binding]; other site 226900011402 ATP-binding [chemical binding]; other site 226900011403 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 226900011404 Domain of unknown function DUF; Region: DUF204; pfam02659 226900011405 Domain of unknown function DUF; Region: DUF204; pfam02659 226900011406 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 226900011407 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 226900011408 DNA binding site [nucleotide binding] 226900011409 catalytic residue [active] 226900011410 H2TH interface [polypeptide binding]; other site 226900011411 putative catalytic residues [active] 226900011412 turnover-facilitating residue; other site 226900011413 intercalation triad [nucleotide binding]; other site 226900011414 8OG recognition residue [nucleotide binding]; other site 226900011415 putative reading head residues; other site 226900011416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 226900011417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226900011418 DNA polymerase I; Provisional; Region: PRK05755 226900011419 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226900011420 active site 226900011421 metal binding site 1 [ion binding]; metal-binding site 226900011422 putative 5' ssDNA interaction site; other site 226900011423 metal binding site 3; metal-binding site 226900011424 metal binding site 2 [ion binding]; metal-binding site 226900011425 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226900011426 putative DNA binding site [nucleotide binding]; other site 226900011427 putative metal binding site [ion binding]; other site 226900011428 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 226900011429 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 226900011430 active site 226900011431 DNA binding site [nucleotide binding] 226900011432 catalytic site [active] 226900011433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900011434 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900011435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900011436 putative active site [active] 226900011437 heme pocket [chemical binding]; other site 226900011438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900011439 dimer interface [polypeptide binding]; other site 226900011440 phosphorylation site [posttranslational modification] 226900011441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011442 ATP binding site [chemical binding]; other site 226900011443 Mg2+ binding site [ion binding]; other site 226900011444 G-X-G motif; other site 226900011445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011447 active site 226900011448 phosphorylation site [posttranslational modification] 226900011449 intermolecular recognition site; other site 226900011450 dimerization interface [polypeptide binding]; other site 226900011451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011452 DNA binding site [nucleotide binding] 226900011453 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 226900011454 dimer interaction site [polypeptide binding]; other site 226900011455 substrate-binding tunnel; other site 226900011456 active site 226900011457 catalytic site [active] 226900011458 substrate binding site [chemical binding]; other site 226900011459 malate dehydrogenase; Reviewed; Region: PRK06223 226900011460 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 226900011461 NAD(P) binding site [chemical binding]; other site 226900011462 dimer interface [polypeptide binding]; other site 226900011463 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900011464 substrate binding site [chemical binding]; other site 226900011465 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 226900011466 isocitrate dehydrogenase; Validated; Region: PRK07362 226900011467 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 226900011468 dimer interface [polypeptide binding]; other site 226900011469 Citrate synthase; Region: Citrate_synt; pfam00285 226900011470 active site 226900011471 citrylCoA binding site [chemical binding]; other site 226900011472 oxalacetate/citrate binding site [chemical binding]; other site 226900011473 coenzyme A binding site [chemical binding]; other site 226900011474 catalytic triad [active] 226900011475 Protein of unknown function (DUF441); Region: DUF441; cl01041 226900011476 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900011477 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 226900011478 pyruvate kinase; Provisional; Region: PRK06354 226900011479 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 226900011480 domain interfaces; other site 226900011481 active site 226900011482 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 226900011483 6-phosphofructokinase; Provisional; Region: PRK03202 226900011484 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 226900011485 active site 226900011486 ADP/pyrophosphate binding site [chemical binding]; other site 226900011487 dimerization interface [polypeptide binding]; other site 226900011488 allosteric effector site; other site 226900011489 fructose-1,6-bisphosphate binding site; other site 226900011490 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 226900011491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 226900011492 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 226900011493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 226900011494 Transcriptional regulators [Transcription]; Region: FadR; COG2186 226900011495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900011496 DNA-binding site [nucleotide binding]; DNA binding site 226900011497 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226900011498 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900011499 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226900011500 putative NAD(P) binding site [chemical binding]; other site 226900011501 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 226900011502 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 226900011503 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226900011504 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 226900011505 generic binding surface II; other site 226900011506 generic binding surface I; other site 226900011507 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 226900011508 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 226900011509 DHH family; Region: DHH; pfam01368 226900011510 DHHA1 domain; Region: DHHA1; pfam02272 226900011511 YtpI-like protein; Region: YtpI; pfam14007 226900011512 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 226900011513 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 226900011514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900011515 DNA-binding site [nucleotide binding]; DNA binding site 226900011516 DRTGG domain; Region: DRTGG; cl12147 226900011517 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 226900011518 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226900011519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900011520 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900011521 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900011522 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900011523 active site 226900011524 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 226900011525 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900011526 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900011527 Cupin domain; Region: Cupin_2; cl09118 226900011528 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 226900011529 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 226900011530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900011531 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900011532 classical (c) SDRs; Region: SDR_c; cd05233 226900011533 NAD(P) binding site [chemical binding]; other site 226900011534 active site 226900011535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226900011536 Ligand Binding Site [chemical binding]; other site 226900011537 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 226900011538 argininosuccinate lyase; Provisional; Region: PRK00855 226900011539 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 226900011540 active sites [active] 226900011541 tetramer interface [polypeptide binding]; other site 226900011542 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 226900011543 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 226900011544 ANP binding site [chemical binding]; other site 226900011545 Substrate Binding Site II [chemical binding]; other site 226900011546 Substrate Binding Site I [chemical binding]; other site 226900011547 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900011548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900011549 EcsC protein family; Region: EcsC; pfam12787 226900011550 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 226900011551 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 226900011552 nudix motif; other site 226900011553 Acetokinase family; Region: Acetate_kinase; cl01029 226900011554 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 226900011555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011556 S-adenosylmethionine binding site [chemical binding]; other site 226900011557 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 226900011558 dimer interface [polypeptide binding]; other site 226900011559 catalytic triad [active] 226900011560 peroxidatic and resolving cysteines [active] 226900011561 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900011562 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 226900011563 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 226900011564 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 226900011565 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 226900011566 active site 226900011567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900011568 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900011569 dimer interface [polypeptide binding]; other site 226900011570 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 226900011571 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900011572 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900011573 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 226900011574 THUMP domain; Region: THUMP; cl12076 226900011575 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 226900011576 Ligand Binding Site [chemical binding]; other site 226900011577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900011578 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 226900011579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900011580 catalytic residue [active] 226900011581 septation ring formation regulator EzrA; Provisional; Region: PRK04778 226900011582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900011583 Helix-turn-helix domains; Region: HTH; cl00088 226900011584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900011585 dimerization interface [polypeptide binding]; other site 226900011586 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900011587 EamA-like transporter family; Region: EamA; cl01037 226900011588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900011589 Helix-turn-helix domains; Region: HTH; cl00088 226900011590 GAF domain; Region: GAF; cl00853 226900011591 methionine gamma-lyase; Provisional; Region: PRK06767 226900011592 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900011593 homodimer interface [polypeptide binding]; other site 226900011594 substrate-cofactor binding pocket; other site 226900011595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011596 catalytic residue [active] 226900011597 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 226900011598 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 226900011599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900011600 RNA binding surface [nucleotide binding]; other site 226900011601 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 226900011602 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 226900011603 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 226900011604 active site 226900011605 HIGH motif; other site 226900011606 dimer interface [polypeptide binding]; other site 226900011607 KMSKS motif; other site 226900011608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900011609 RNA binding surface [nucleotide binding]; other site 226900011610 maltose O-acetyltransferase; Provisional; Region: PRK10092 226900011611 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226900011612 active site 226900011613 substrate binding site [chemical binding]; other site 226900011614 trimer interface [polypeptide binding]; other site 226900011615 CoA binding site [chemical binding]; other site 226900011616 acetyl-CoA synthetase; Provisional; Region: PRK04319 226900011617 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 226900011618 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900011619 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900011620 FOG: CBS domain [General function prediction only]; Region: COG0517 226900011621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 226900011622 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 226900011623 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 226900011624 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 226900011625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900011626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011628 active site 226900011629 phosphorylation site [posttranslational modification] 226900011630 intermolecular recognition site; other site 226900011631 dimerization interface [polypeptide binding]; other site 226900011632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011633 DNA binding site [nucleotide binding] 226900011634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900011635 dimerization interface [polypeptide binding]; other site 226900011636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900011637 dimer interface [polypeptide binding]; other site 226900011638 phosphorylation site [posttranslational modification] 226900011639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011640 ATP binding site [chemical binding]; other site 226900011641 Mg2+ binding site [ion binding]; other site 226900011642 G-X-G motif; other site 226900011643 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900011644 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900011645 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900011646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226900011647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900011648 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 226900011649 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 226900011650 catabolite control protein A; Region: ccpA; TIGR01481 226900011651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900011652 DNA binding site [nucleotide binding] 226900011653 domain linker motif; other site 226900011654 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 226900011655 dimerization interface [polypeptide binding]; other site 226900011656 effector binding site; other site 226900011657 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 226900011658 Chorismate mutase type II; Region: CM_2; cl00693 226900011659 NeuB family; Region: NeuB; cl00496 226900011660 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 226900011661 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226900011662 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 226900011663 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900011664 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 226900011665 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900011666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900011667 Coenzyme A binding pocket [chemical binding]; other site 226900011668 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900011669 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 226900011670 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900011671 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 226900011672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900011673 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 226900011674 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 226900011675 active site 226900011676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900011677 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 226900011678 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900011679 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900011680 active site 226900011681 metal binding site [ion binding]; metal-binding site 226900011682 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226900011683 putative tRNA-binding site [nucleotide binding]; other site 226900011684 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 226900011685 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900011686 catalytic residues [active] 226900011687 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 226900011688 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 226900011689 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226900011690 oligomer interface [polypeptide binding]; other site 226900011691 active site 226900011692 metal binding site [ion binding]; metal-binding site 226900011693 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 226900011694 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900011695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011696 S-adenosylmethionine binding site [chemical binding]; other site 226900011697 YtzH-like protein; Region: YtzH; pfam14165 226900011698 Phosphotransferase enzyme family; Region: APH; pfam01636 226900011699 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900011700 active site 226900011701 substrate binding site [chemical binding]; other site 226900011702 ATP binding site [chemical binding]; other site 226900011703 similar to Pullulanase; EC_number 3.2.1.41 226900011704 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 226900011705 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 226900011706 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 226900011707 dipeptidase PepV; Reviewed; Region: PRK07318 226900011708 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 226900011709 active site 226900011710 metal binding site [ion binding]; metal-binding site 226900011711 Helix-turn-helix domains; Region: HTH; cl00088 226900011712 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900011713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900011714 RNA binding surface [nucleotide binding]; other site 226900011715 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 226900011716 active site 226900011717 uracil binding [chemical binding]; other site 226900011718 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900011719 MatE; Region: MatE; cl10513 226900011720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900011721 flavoprotein, HI0933 family; Region: TIGR00275 226900011722 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011724 putative substrate translocation pore; other site 226900011725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900011727 dimerization interface [polypeptide binding]; other site 226900011728 putative DNA binding site [nucleotide binding]; other site 226900011729 putative Zn2+ binding site [ion binding]; other site 226900011730 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 226900011731 putative hydrophobic ligand binding site [chemical binding]; other site 226900011732 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 226900011733 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 226900011734 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 226900011735 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 226900011736 glucose-1-dehydrogenase; Provisional; Region: PRK08936 226900011737 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 226900011738 NAD binding site [chemical binding]; other site 226900011739 homodimer interface [polypeptide binding]; other site 226900011740 active site 226900011741 Sugar transport protein; Region: Sugar_transport; pfam06800 226900011742 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 226900011743 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900011744 MoaE interaction surface [polypeptide binding]; other site 226900011745 MoeB interaction surface [polypeptide binding]; other site 226900011746 thiocarboxylated glycine; other site 226900011747 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900011748 MoaE homodimer interface [polypeptide binding]; other site 226900011749 MoaD interaction [polypeptide binding]; other site 226900011750 active site residues [active] 226900011751 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 226900011752 Walker A motif; other site 226900011753 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900011754 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900011755 dimer interface [polypeptide binding]; other site 226900011756 putative functional site; other site 226900011757 putative MPT binding site; other site 226900011758 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 226900011759 trimer interface [polypeptide binding]; other site 226900011760 dimer interface [polypeptide binding]; other site 226900011761 putative active site [active] 226900011762 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 226900011763 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900011764 ATP binding site [chemical binding]; other site 226900011765 substrate interface [chemical binding]; other site 226900011766 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 226900011767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900011768 FeS/SAM binding site; other site 226900011769 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900011770 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900011771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900011772 active site residue [active] 226900011773 homoserine O-acetyltransferase; Provisional; Region: PRK06765 226900011774 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 226900011775 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900011776 Amino acid permease; Region: AA_permease; cl00524 226900011777 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 226900011778 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900011779 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 226900011780 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 226900011781 HIGH motif; other site 226900011782 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 226900011783 active site 226900011784 KMSKS motif; other site 226900011785 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 226900011786 tRNA binding surface [nucleotide binding]; other site 226900011787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900011789 putative substrate translocation pore; other site 226900011790 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 226900011791 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900011792 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 226900011793 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900011794 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900011795 Phage integrase family; Region: Phage_integrase; pfam00589 226900011796 Int/Topo IB signature motif; other site 226900011797 FtsX-like permease family; Region: FtsX; pfam02687 226900011798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900011799 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900011800 Walker A/P-loop; other site 226900011801 ATP binding site [chemical binding]; other site 226900011802 Q-loop/lid; other site 226900011803 ABC transporter signature motif; other site 226900011804 Walker B; other site 226900011805 D-loop; other site 226900011806 H-loop/switch region; other site 226900011807 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900011808 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900011809 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 226900011810 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 226900011811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900011812 FeS/SAM binding site; other site 226900011813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900011814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900011815 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 226900011816 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900011817 Walker A/P-loop; other site 226900011818 ATP binding site [chemical binding]; other site 226900011819 Q-loop/lid; other site 226900011820 ABC transporter signature motif; other site 226900011821 Walker B; other site 226900011822 D-loop; other site 226900011823 H-loop/switch region; other site 226900011824 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900011825 aspartate racemase; Region: asp_race; TIGR00035 226900011826 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 226900011827 PepSY-associated TM helix; Region: PepSY_TM; pfam03929 226900011828 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 226900011829 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226900011830 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900011831 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 226900011832 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 226900011833 trimer interface [polypeptide binding]; other site 226900011834 putative metal binding site [ion binding]; other site 226900011835 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 226900011836 active site 226900011837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900011838 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 226900011839 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 226900011840 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 226900011841 GTP binding site; other site 226900011842 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 226900011843 MPT binding site; other site 226900011844 trimer interface [polypeptide binding]; other site 226900011845 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900011846 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900011847 S-adenosylmethionine synthetase; Validated; Region: PRK05250 226900011848 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 226900011849 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 226900011850 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 226900011851 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 226900011852 active site 226900011853 substrate-binding site [chemical binding]; other site 226900011854 metal-binding site [ion binding] 226900011855 ATP binding site [chemical binding]; other site 226900011856 ATP synthase I chain; Region: ATP_synt_I; cl09170 226900011857 EamA-like transporter family; Region: EamA; cl01037 226900011858 EamA-like transporter family; Region: EamA; cl01037 226900011859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 226900011860 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 226900011861 sensor protein ZraS; Provisional; Region: PRK10364 226900011862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011863 ATP binding site [chemical binding]; other site 226900011864 Mg2+ binding site [ion binding]; other site 226900011865 G-X-G motif; other site 226900011866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900011867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900011868 dimer interface [polypeptide binding]; other site 226900011869 phosphorylation site [posttranslational modification] 226900011870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011871 ATP binding site [chemical binding]; other site 226900011872 Mg2+ binding site [ion binding]; other site 226900011873 G-X-G motif; other site 226900011874 similar to Catalase; EC_number 1.11.1.6 226900011875 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900011876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900011877 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 226900011878 Sulfatase; Region: Sulfatase; cl10460 226900011879 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 226900011880 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 226900011881 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900011882 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 226900011883 Walker A/P-loop; other site 226900011884 ATP binding site [chemical binding]; other site 226900011885 Q-loop/lid; other site 226900011886 ABC transporter signature motif; other site 226900011887 Walker B; other site 226900011888 D-loop; other site 226900011889 H-loop/switch region; other site 226900011890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900011891 dimer interface [polypeptide binding]; other site 226900011892 conserved gate region; other site 226900011893 putative PBP binding loops; other site 226900011894 ABC-ATPase subunit interface; other site 226900011895 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900011896 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226900011897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900011898 motif II; other site 226900011899 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 226900011900 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 226900011901 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 226900011902 nudix motif; other site 226900011903 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 226900011904 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 226900011905 Domain of unknown function DUF37; Region: DUF37; cl00506 226900011906 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 226900011907 active site clefts [active] 226900011908 zinc binding site [ion binding]; other site 226900011909 dimer interface [polypeptide binding]; other site 226900011910 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 226900011911 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 226900011912 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226900011913 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900011914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900011915 putative active site [active] 226900011916 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900011917 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900011918 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900011919 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900011920 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 226900011921 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 226900011922 Predicted membrane protein [Function unknown]; Region: COG3766 226900011923 PspA/IM30 family; Region: PspA_IM30; pfam04012 226900011924 hypothetical protein; Provisional; Region: PRK06760; cl11698 226900011925 Integrase core domain; Region: rve; cl01316 226900011926 similar to Ferrous iron transport protein B 226900011927 FeoA domain; Region: FeoA; cl00838 226900011928 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900011929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900011930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900011931 dimerization interface [polypeptide binding]; other site 226900011932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900011933 dimer interface [polypeptide binding]; other site 226900011934 phosphorylation site [posttranslational modification] 226900011935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011936 ATP binding site [chemical binding]; other site 226900011937 Mg2+ binding site [ion binding]; other site 226900011938 G-X-G motif; other site 226900011939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011941 active site 226900011942 phosphorylation site [posttranslational modification] 226900011943 intermolecular recognition site; other site 226900011944 dimerization interface [polypeptide binding]; other site 226900011945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011946 DNA binding site [nucleotide binding] 226900011947 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 226900011948 active site 226900011949 catalytic site [active] 226900011950 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900011951 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 226900011952 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 226900011953 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 226900011954 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 226900011955 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 226900011956 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 226900011957 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 226900011958 FtsX-like permease family; Region: FtsX; pfam02687 226900011959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900011960 ABC transporter signature motif; other site 226900011961 Walker B; other site 226900011962 D-loop; other site 226900011963 H-loop/switch region; other site 226900011964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900011965 Walker A/P-loop; other site 226900011966 ATP binding site [chemical binding]; other site 226900011967 Q-loop/lid; other site 226900011968 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900011969 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900011970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011971 S-adenosylmethionine binding site [chemical binding]; other site 226900011972 FtsX-like permease family; Region: FtsX; pfam02687 226900011973 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900011974 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900011975 Walker A/P-loop; other site 226900011976 ATP binding site [chemical binding]; other site 226900011977 Q-loop/lid; other site 226900011978 ABC transporter signature motif; other site 226900011979 Walker B; other site 226900011980 D-loop; other site 226900011981 H-loop/switch region; other site 226900011982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900011983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900011984 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900011985 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 226900011986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900011987 dimerization interface [polypeptide binding]; other site 226900011988 putative DNA binding site [nucleotide binding]; other site 226900011989 putative Zn2+ binding site [ion binding]; other site 226900011990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011992 active site 226900011993 phosphorylation site [posttranslational modification] 226900011994 intermolecular recognition site; other site 226900011995 dimerization interface [polypeptide binding]; other site 226900011996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011997 DNA binding site [nucleotide binding] 226900011998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900011999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 226900012000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012001 ATP binding site [chemical binding]; other site 226900012002 Mg2+ binding site [ion binding]; other site 226900012003 G-X-G motif; other site 226900012004 FtsX-like permease family; Region: FtsX; pfam02687 226900012005 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 226900012006 FtsX-like permease family; Region: FtsX; pfam02687 226900012007 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012008 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900012009 Walker A/P-loop; other site 226900012010 ATP binding site [chemical binding]; other site 226900012011 Q-loop/lid; other site 226900012012 ABC transporter signature motif; other site 226900012013 Walker B; other site 226900012014 D-loop; other site 226900012015 H-loop/switch region; other site 226900012016 GntP family permease; Region: GntP_permease; cl15264 226900012017 gluconate transporter; Region: gntP; TIGR00791 226900012018 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900012019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900012020 DNA-binding site [nucleotide binding]; DNA binding site 226900012021 UTRA domain; Region: UTRA; cl01230 226900012022 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 226900012023 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226900012024 substrate binding site [chemical binding]; other site 226900012025 ATP binding site [chemical binding]; other site 226900012026 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 226900012027 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 226900012028 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 226900012029 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 226900012030 active site 226900012031 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900012032 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 226900012033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 226900012034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012035 dimer interface [polypeptide binding]; other site 226900012036 phosphorylation site [posttranslational modification] 226900012037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012038 ATP binding site [chemical binding]; other site 226900012039 Mg2+ binding site [ion binding]; other site 226900012040 G-X-G motif; other site 226900012041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012043 active site 226900012044 phosphorylation site [posttranslational modification] 226900012045 intermolecular recognition site; other site 226900012046 dimerization interface [polypeptide binding]; other site 226900012047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012048 DNA binding site [nucleotide binding] 226900012049 similar to O-succinylbenzoate-CoA synthase 226900012050 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 226900012051 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 226900012052 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 226900012053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900012054 substrate binding site [chemical binding]; other site 226900012055 oxyanion hole (OAH) forming residues; other site 226900012056 trimer interface [polypeptide binding]; other site 226900012057 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 226900012058 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 226900012059 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 226900012060 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 226900012061 dimer interface [polypeptide binding]; other site 226900012062 tetramer interface [polypeptide binding]; other site 226900012063 PYR/PP interface [polypeptide binding]; other site 226900012064 TPP binding site [chemical binding]; other site 226900012065 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 226900012066 TPP-binding site; other site 226900012067 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 226900012068 chorismate binding enzyme; Region: Chorismate_bind; cl10555 226900012069 UbiA prenyltransferase family; Region: UbiA; cl00337 226900012070 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 226900012071 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900012072 DNA-binding site [nucleotide binding]; DNA binding site 226900012073 RNA-binding motif; other site 226900012074 Protein of unknown function DUF124; Region: DUF124; cl00884 226900012075 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 226900012076 active site flap/lid [active] 226900012077 nucleophilic elbow; other site 226900012078 catalytic triad [active] 226900012079 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 226900012080 homodimer interface [polypeptide binding]; other site 226900012081 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 226900012082 active site pocket [active] 226900012083 glycogen synthase; Provisional; Region: glgA; PRK00654 226900012084 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 226900012085 ADP-binding pocket [chemical binding]; other site 226900012086 homodimer interface [polypeptide binding]; other site 226900012087 similar to Glucose-1-phosphate adenylyltransferase; EC_number 2.7.7.27 226900012088 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 226900012089 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 226900012090 ligand binding site; other site 226900012091 oligomer interface; other site 226900012092 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 226900012093 dimer interface [polypeptide binding]; other site 226900012094 N-terminal domain interface [polypeptide binding]; other site 226900012095 sulfate 1 binding site; other site 226900012096 glycogen branching enzyme; Provisional; Region: PRK12313 226900012097 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 226900012098 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 226900012099 active site 226900012100 catalytic site [active] 226900012101 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 226900012102 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 226900012103 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900012104 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900012105 putative active site [active] 226900012106 catalytic triad [active] 226900012107 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 226900012108 PA/protease domain interface [polypeptide binding]; other site 226900012109 putative integrin binding motif; other site 226900012110 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900012111 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 226900012112 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900012113 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900012114 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900012115 NAD binding site [chemical binding]; other site 226900012116 dimer interface [polypeptide binding]; other site 226900012117 substrate binding site [chemical binding]; other site 226900012118 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226900012119 MgtC family; Region: MgtC; cl12207 226900012120 similar to Potassium channel protein 226900012121 YugN-like family; Region: YugN; pfam08868 226900012122 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 226900012123 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 226900012124 active site 226900012125 dimer interface [polypeptide binding]; other site 226900012126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 226900012127 dimer interface [polypeptide binding]; other site 226900012128 active site 226900012129 Domain of unknown function (DUF378); Region: DUF378; cl00943 226900012130 general stress protein 13; Validated; Region: PRK08059 226900012131 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900012132 RNA binding site [nucleotide binding]; other site 226900012133 hypothetical protein; Validated; Region: PRK07682 226900012134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900012135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900012136 homodimer interface [polypeptide binding]; other site 226900012137 catalytic residue [active] 226900012138 Helix-turn-helix domains; Region: HTH; cl00088 226900012139 Helix-turn-helix domains; Region: HTH; cl00088 226900012140 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 226900012141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900012143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900012144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 226900012145 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 226900012146 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 226900012147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900012148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900012149 homodimer interface [polypeptide binding]; other site 226900012150 catalytic residue [active] 226900012151 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 226900012152 E-class dimer interface [polypeptide binding]; other site 226900012153 P-class dimer interface [polypeptide binding]; other site 226900012154 active site 226900012155 Cu2+ binding site [ion binding]; other site 226900012156 Zn2+ binding site [ion binding]; other site 226900012157 Kinase associated protein B; Region: KapB; pfam08810 226900012158 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 226900012159 active site 226900012160 substrate binding site [chemical binding]; other site 226900012161 catalytic site [active] 226900012162 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 226900012163 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 226900012164 transmembrane helices; other site 226900012165 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 226900012166 active site 226900012167 similar to Glycyl-tRNA synthetase; EC_number 6.1.1.14 226900012168 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 226900012169 CoenzymeA binding site [chemical binding]; other site 226900012170 subunit interaction site [polypeptide binding]; other site 226900012171 PHB binding site; other site 226900012172 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 226900012173 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900012174 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 226900012175 active site 226900012176 tetramer interface; other site 226900012177 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 226900012178 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 226900012179 active site 226900012180 substrate binding site [chemical binding]; other site 226900012181 metal binding site [ion binding]; metal-binding site 226900012182 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 226900012183 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900012184 multifunctional aminopeptidase A; Provisional; Region: PRK00913 226900012185 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 226900012186 interface (dimer of trimers) [polypeptide binding]; other site 226900012187 Substrate-binding/catalytic site; other site 226900012188 Zn-binding sites [ion binding]; other site 226900012189 3D domain; Region: 3D; cl01439 226900012190 Putative membrane protein; Region: YuiB; pfam14068 226900012191 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900012192 nudix motif; other site 226900012193 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900012194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012195 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900012196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012198 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012199 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012200 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012201 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012202 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012203 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012204 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012205 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012206 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012207 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012208 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012209 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012210 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012211 Domain of unknown function DUF11; Region: DUF11; cl15273 226900012212 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 226900012213 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900012214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012215 putative substrate translocation pore; other site 226900012216 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900012217 Protein of unknown function (DUF523); Region: DUF523; cl00733 226900012218 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900012219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900012220 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 226900012221 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226900012222 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 226900012223 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 226900012224 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 226900012225 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 226900012226 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900012227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012228 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900012229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900012231 Walker A/P-loop; other site 226900012232 ATP binding site [chemical binding]; other site 226900012233 Q-loop/lid; other site 226900012234 ABC transporter signature motif; other site 226900012235 Walker B; other site 226900012236 D-loop; other site 226900012237 H-loop/switch region; other site 226900012238 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 226900012239 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 226900012240 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 226900012241 PhnA protein; Region: PhnA; pfam03831 226900012242 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 226900012243 similar to hypothetical protein 226900012244 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 226900012245 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 226900012246 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226900012247 active site 226900012248 NTP binding site [chemical binding]; other site 226900012249 metal binding triad [ion binding]; metal-binding site 226900012250 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 226900012251 NifU-like domain; Region: NifU; cl00484 226900012252 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 226900012253 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 226900012254 tetramer interfaces [polypeptide binding]; other site 226900012255 binuclear metal-binding site [ion binding]; other site 226900012256 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226900012257 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900012258 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900012259 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 226900012260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900012261 active site 226900012262 motif I; other site 226900012263 motif II; other site 226900012264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900012265 Predicted transcriptional regulator [Transcription]; Region: COG2345 226900012266 Helix-turn-helix domains; Region: HTH; cl00088 226900012267 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 226900012268 Protein of unknown function DUF86; Region: DUF86; cl01031 226900012269 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 226900012270 putative active site [active] 226900012271 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 226900012272 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 226900012273 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012274 RNA binding surface [nucleotide binding]; other site 226900012275 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 226900012276 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900012277 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900012278 DNA binding residues [nucleotide binding] 226900012279 dimer interface [polypeptide binding]; other site 226900012280 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226900012281 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 226900012282 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900012283 catalytic core [active] 226900012284 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 226900012285 putative deacylase active site [active] 226900012286 lipoyl synthase; Provisional; Region: PRK05481 226900012287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900012288 FeS/SAM binding site; other site 226900012289 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900012290 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 226900012291 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 226900012292 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 226900012293 active site 226900012294 metal binding site [ion binding]; metal-binding site 226900012295 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900012296 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 226900012297 FeS assembly protein SufB; Region: sufB; TIGR01980 226900012298 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 226900012299 trimerization site [polypeptide binding]; other site 226900012300 active site 226900012301 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 226900012302 Aminotransferase class-V; Region: Aminotran_5; pfam00266 226900012303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900012304 catalytic residue [active] 226900012305 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 226900012306 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 226900012307 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 226900012308 FeS assembly ATPase SufC; Region: sufC; TIGR01978 226900012309 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 226900012310 Walker A/P-loop; other site 226900012311 ATP binding site [chemical binding]; other site 226900012312 Q-loop/lid; other site 226900012313 ABC transporter signature motif; other site 226900012314 Walker B; other site 226900012315 D-loop; other site 226900012316 H-loop/switch region; other site 226900012317 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900012318 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 226900012319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900012320 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 226900012321 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 226900012322 Walker A/P-loop; other site 226900012323 ATP binding site [chemical binding]; other site 226900012324 Q-loop/lid; other site 226900012325 ABC transporter signature motif; other site 226900012326 Walker B; other site 226900012327 D-loop; other site 226900012328 H-loop/switch region; other site 226900012329 NIL domain; Region: NIL; cl09633 226900012330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900012331 catalytic residues [active] 226900012332 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 226900012333 putative active site [active] 226900012334 putative metal binding site [ion binding]; other site 226900012335 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 226900012336 lipoyl attachment site [posttranslational modification]; other site 226900012337 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 226900012338 ArsC family; Region: ArsC; pfam03960 226900012339 putative ArsC-like catalytic residues; other site 226900012340 putative TRX-like catalytic residues [active] 226900012341 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 226900012342 active site 226900012343 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900012344 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900012345 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900012346 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900012347 NAD binding site [chemical binding]; other site 226900012348 dimer interface [polypeptide binding]; other site 226900012349 substrate binding site [chemical binding]; other site 226900012350 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 226900012351 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 226900012352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900012353 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900012354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226900012355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 226900012356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900012357 active site 226900012358 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 226900012359 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900012360 dimer interface [polypeptide binding]; other site 226900012361 active site 226900012362 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 226900012363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900012364 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900012365 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 226900012366 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900012367 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900012368 substrate binding site [chemical binding]; other site 226900012369 oxyanion hole (OAH) forming residues; other site 226900012370 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900012371 Proline dehydrogenase; Region: Pro_dh; cl03282 226900012372 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 226900012373 Domain of unknown function DUF77; Region: DUF77; cl00307 226900012374 Cache domain; Region: Cache_1; pfam02743 226900012375 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 226900012376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012377 dimerization interface [polypeptide binding]; other site 226900012378 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 226900012379 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900012380 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900012381 Helix-turn-helix domains; Region: HTH; cl00088 226900012382 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900012383 C-terminal domain interface [polypeptide binding]; other site 226900012384 sugar binding site [chemical binding]; other site 226900012385 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900012386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012387 putative substrate translocation pore; other site 226900012388 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900012389 Amino acid permease; Region: AA_permease; cl00524 226900012390 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 226900012391 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900012392 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900012393 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 226900012394 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900012395 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900012396 hypothetical protein; Provisional; Region: PRK06758 226900012397 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 226900012398 active site 226900012399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900012400 salt bridge; other site 226900012401 non-specific DNA binding site [nucleotide binding]; other site 226900012402 sequence-specific DNA binding site [nucleotide binding]; other site 226900012403 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900012404 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 226900012405 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 226900012406 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012408 active site 226900012409 phosphorylation site [posttranslational modification] 226900012410 intermolecular recognition site; other site 226900012411 dimerization interface [polypeptide binding]; other site 226900012412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012413 DNA binding site [nucleotide binding] 226900012414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900012415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012416 dimer interface [polypeptide binding]; other site 226900012417 phosphorylation site [posttranslational modification] 226900012418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012419 ATP binding site [chemical binding]; other site 226900012420 Mg2+ binding site [ion binding]; other site 226900012421 G-X-G motif; other site 226900012422 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900012423 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 226900012424 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226900012425 active site 226900012426 HIGH motif; other site 226900012427 KMSKS motif; other site 226900012428 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226900012429 tRNA binding surface [nucleotide binding]; other site 226900012430 anticodon binding site; other site 226900012431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012432 S-adenosylmethionine binding site [chemical binding]; other site 226900012433 similar to Methyl-accepting chemotaxis protein 226900012434 CHASE3 domain; Region: CHASE3; cl05000 226900012435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012436 dimerization interface [polypeptide binding]; other site 226900012437 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900012438 Domain of unknown function DUF59; Region: DUF59; cl00941 226900012439 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900012440 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 226900012441 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900012442 active site 226900012443 Zn binding site [ion binding]; other site 226900012444 Pirin-related protein [General function prediction only]; Region: COG1741 226900012445 Cupin domain; Region: Cupin_2; cl09118 226900012446 Helix-turn-helix domains; Region: HTH; cl00088 226900012447 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 226900012448 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900012449 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226900012450 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 226900012451 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900012452 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 226900012453 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900012454 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900012455 Ferritin-like domain; Region: Ferritin; pfam00210 226900012456 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226900012457 dimerization interface [polypeptide binding]; other site 226900012458 DPS ferroxidase diiron center [ion binding]; other site 226900012459 ion pore; other site 226900012460 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 226900012461 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 226900012462 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 226900012463 Ferritin-like domain; Region: Ferritin; pfam00210 226900012464 ferroxidase diiron center [ion binding]; other site 226900012465 Predicted membrane protein [Function unknown]; Region: COG2311 226900012466 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900012467 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900012468 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900012469 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900012470 Nucleoside recognition; Region: Gate; cl00486 226900012471 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900012472 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 226900012473 similar to Sodium/proton-dependent alanine carrier protein 226900012474 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 226900012475 NAD binding site [chemical binding]; other site 226900012476 substrate binding site [chemical binding]; other site 226900012477 putative active site [active] 226900012478 Viral enhancin protein; Region: Enhancin; pfam03272 226900012479 Viral enhancin protein; Region: Enhancin; pfam03272 226900012480 TQXA domain; Region: TQXA_dom; TIGR03934 226900012481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900012482 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 226900012483 active site 226900012484 catalytic tetrad [active] 226900012485 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900012486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012487 putative substrate translocation pore; other site 226900012488 Helix-turn-helix domains; Region: HTH; cl00088 226900012489 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 226900012490 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900012491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012492 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 226900012493 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 226900012494 active site 226900012495 HIGH motif; other site 226900012496 dimer interface [polypeptide binding]; other site 226900012497 KMSKS motif; other site 226900012498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012499 RNA binding surface [nucleotide binding]; other site 226900012500 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 226900012501 FAD binding domain; Region: FAD_binding_4; pfam01565 226900012502 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226900012503 SET domain; Region: SET; cl02566 226900012504 Aluminium activated malate transporter; Region: ALMT; pfam11744 226900012505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900012506 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900012507 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226900012508 putative phosphate binding site [ion binding]; other site 226900012509 CrcB-like protein; Region: CRCB; cl09114 226900012510 CrcB-like protein; Region: CRCB; cl09114 226900012511 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 226900012512 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 226900012513 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900012514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 226900012515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012516 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900012517 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900012518 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900012519 ABC transporter; Region: ABC_tran_2; pfam12848 226900012520 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900012521 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 226900012522 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900012523 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 226900012524 DNA binding residues [nucleotide binding] 226900012525 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900012526 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900012527 23S rRNA interface [nucleotide binding]; other site 226900012528 L7/L12 interface [polypeptide binding]; other site 226900012529 putative thiostrepton binding site; other site 226900012530 L25 interface [polypeptide binding]; other site 226900012531 short chain dehydrogenase; Provisional; Region: PRK06924 226900012532 classical (c) SDRs; Region: SDR_c; cd05233 226900012533 NAD(P) binding site [chemical binding]; other site 226900012534 active site 226900012535 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900012536 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900012537 23S rRNA interface [nucleotide binding]; other site 226900012538 L7/L12 interface [polypeptide binding]; other site 226900012539 putative thiostrepton binding site; other site 226900012540 L25 interface [polypeptide binding]; other site 226900012541 short chain dehydrogenase; Provisional; Region: PRK06841 226900012542 classical (c) SDRs; Region: SDR_c; cd05233 226900012543 NAD(P) binding site [chemical binding]; other site 226900012544 active site 226900012545 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 226900012546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012547 S-adenosylmethionine binding site [chemical binding]; other site 226900012548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900012549 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900012550 NADPH bind site [chemical binding]; other site 226900012551 putative FMN binding site [chemical binding]; other site 226900012552 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900012553 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 226900012554 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 226900012555 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 226900012556 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 226900012557 YcaO-like family; Region: YcaO; cl09146 226900012558 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 226900012559 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900012560 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900012561 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900012562 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 226900012563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900012564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900012565 active site 226900012566 metal binding site [ion binding]; metal-binding site 226900012567 Permease family; Region: Xan_ur_permease; cl00967 226900012568 HTH-like domain; Region: HTH_21; pfam13276 226900012569 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900012570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900012571 putative DNA binding site [nucleotide binding]; other site 226900012572 putative Zn2+ binding site [ion binding]; other site 226900012573 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900012574 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 226900012575 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 226900012576 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900012577 Walker A/P-loop; other site 226900012578 ATP binding site [chemical binding]; other site 226900012579 Q-loop/lid; other site 226900012580 ABC transporter signature motif; other site 226900012581 Walker B; other site 226900012582 D-loop; other site 226900012583 H-loop/switch region; other site 226900012584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900012585 ABC-ATPase subunit interface; other site 226900012586 dimer interface [polypeptide binding]; other site 226900012587 putative PBP binding regions; other site 226900012588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900012589 ABC-ATPase subunit interface; other site 226900012590 dimer interface [polypeptide binding]; other site 226900012591 putative PBP binding regions; other site 226900012592 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 226900012593 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 226900012594 putative ligand binding residues [chemical binding]; other site 226900012595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012597 active site 226900012598 phosphorylation site [posttranslational modification] 226900012599 intermolecular recognition site; other site 226900012600 dimerization interface [polypeptide binding]; other site 226900012601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012602 DNA binding site [nucleotide binding] 226900012603 TniQ; Region: TniQ; pfam06527 226900012604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900012605 Archaeal ATPase; Region: Arch_ATPase; pfam01637 226900012606 Walker A motif; other site 226900012607 ATP binding site [chemical binding]; other site 226900012608 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 226900012609 Integrase core domain; Region: rve; cl01316 226900012610 Helix-turn-helix domains; Region: HTH; cl00088 226900012611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226900012612 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 226900012613 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900012614 Walker A/P-loop; other site 226900012615 ATP binding site [chemical binding]; other site 226900012616 Q-loop/lid; other site 226900012617 ABC transporter signature motif; other site 226900012618 Walker B; other site 226900012619 D-loop; other site 226900012620 H-loop/switch region; other site 226900012621 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 226900012622 FMN binding site [chemical binding]; other site 226900012623 dimer interface [polypeptide binding]; other site 226900012624 YcaO-like family; Region: YcaO; cl09146 226900012625 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 226900012626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226900012627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226900012628 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 226900012629 SmpB-tmRNA interface; other site 226900012630 ribonuclease R; Region: RNase_R; TIGR02063 226900012631 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900012632 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900012633 RNB domain; Region: RNB; pfam00773 226900012634 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 226900012635 RNA binding site [nucleotide binding]; other site 226900012636 Esterase/lipase [General function prediction only]; Region: COG1647 226900012637 Preprotein translocase SecG subunit; Region: SecG; cl09123 226900012638 LrgB-like family; Region: LrgB; cl00596 226900012639 LrgA family; Region: LrgA; cl00608 226900012640 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900012641 active site 226900012642 enolase; Provisional; Region: eno; PRK00077 226900012643 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 226900012644 dimer interface [polypeptide binding]; other site 226900012645 metal binding site [ion binding]; metal-binding site 226900012646 substrate binding pocket [chemical binding]; other site 226900012647 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 226900012648 Sulfatase; Region: Sulfatase; cl10460 226900012649 similar to Triosephosphate isomerase; EC_number 5.3.1.1 226900012650 similar to Phosphoglycerate kinase; EC_number 2.7.2.3 226900012651 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 226900012652 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 226900012653 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226900012654 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900012655 Predicted transcriptional regulator [Transcription]; Region: COG3388 226900012656 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900012657 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226900012658 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 226900012659 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 226900012660 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 226900012661 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 226900012662 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900012663 SpoVA protein; Region: SpoVA; cl04298 226900012664 stage V sporulation protein AD; Provisional; Region: PRK12404 226900012665 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 226900012666 SpoVA protein; Region: SpoVA; cl04298 226900012667 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900012668 Protein of unknown function (DUF421); Region: DUF421; cl00990 226900012669 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900012670 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226900012671 oligomer interface [polypeptide binding]; other site 226900012672 active site residues [active] 226900012673 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 226900012674 dimerization domain swap beta strand [polypeptide binding]; other site 226900012675 regulatory protein interface [polypeptide binding]; other site 226900012676 active site 226900012677 regulatory phosphorylation site [posttranslational modification]; other site 226900012678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 226900012679 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 226900012680 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 226900012681 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 226900012682 phosphate binding site [ion binding]; other site 226900012683 putative substrate binding pocket [chemical binding]; other site 226900012684 dimer interface [polypeptide binding]; other site 226900012685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900012686 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 226900012687 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900012688 putative active site [active] 226900012689 nucleotide binding site [chemical binding]; other site 226900012690 nudix motif; other site 226900012691 putative metal binding site [ion binding]; other site 226900012692 Domain of unknown function (DUF368); Region: DUF368; cl00893 226900012693 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 226900012694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900012697 binding surface 226900012698 TPR motif; other site 226900012699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900012700 binding surface 226900012701 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 226900012702 TPR motif; other site 226900012703 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226900012704 trimer interface [polypeptide binding]; other site 226900012705 active site 226900012706 substrate binding site [chemical binding]; other site 226900012707 CoA binding site [chemical binding]; other site 226900012708 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900012709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900012710 active site 226900012711 motif I; other site 226900012712 motif II; other site 226900012713 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 226900012714 HPr kinase/phosphorylase; Provisional; Region: PRK05428 226900012715 DRTGG domain; Region: DRTGG; cl12147 226900012716 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 226900012717 Hpr binding site; other site 226900012718 active site 226900012719 homohexamer subunit interaction site [polypeptide binding]; other site 226900012720 Membrane protein of unknown function; Region: DUF360; cl00850 226900012721 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 226900012722 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 226900012723 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 226900012724 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 226900012725 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 226900012726 excinuclease ABC subunit B; Provisional; Region: PRK05298 226900012727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900012728 ATP binding site [chemical binding]; other site 226900012729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900012730 nucleotide binding region [chemical binding]; other site 226900012731 ATP-binding site [chemical binding]; other site 226900012732 Ultra-violet resistance protein B; Region: UvrB; pfam12344 226900012733 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 226900012734 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900012735 DNA binding residues [nucleotide binding] 226900012736 dimer interface [polypeptide binding]; other site 226900012737 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226900012738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900012739 non-specific DNA binding site [nucleotide binding]; other site 226900012740 salt bridge; other site 226900012741 sequence-specific DNA binding site [nucleotide binding]; other site 226900012742 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 226900012743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900012744 Helix-turn-helix domains; Region: HTH; cl00088 226900012745 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 226900012746 putative dimerization interface [polypeptide binding]; other site 226900012747 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900012748 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 226900012749 DNA binding residues [nucleotide binding] 226900012750 putative dimer interface [polypeptide binding]; other site 226900012751 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900012752 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900012753 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900012754 ABC transporter; Region: ABC_tran_2; pfam12848 226900012755 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900012756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900012757 putative transposase OrfB; Reviewed; Region: PHA02517 226900012758 Integrase core domain; Region: rve; cl01316 226900012759 Domain of unknown function (DUF74); Region: DUF74; cl00426 226900012760 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900012761 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 226900012762 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 226900012763 Walker A/P-loop; other site 226900012764 ATP binding site [chemical binding]; other site 226900012765 Q-loop/lid; other site 226900012766 ABC transporter signature motif; other site 226900012767 Walker B; other site 226900012768 D-loop; other site 226900012769 H-loop/switch region; other site 226900012770 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900012771 protein binding site [polypeptide binding]; other site 226900012772 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 226900012773 C-terminal peptidase (prc); Region: prc; TIGR00225 226900012774 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226900012775 protein binding site [polypeptide binding]; other site 226900012776 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226900012777 Catalytic dyad [active] 226900012778 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 226900012779 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 226900012780 FtsX-like permease family; Region: FtsX; pfam02687 226900012781 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 226900012782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900012783 Walker A/P-loop; other site 226900012784 ATP binding site [chemical binding]; other site 226900012785 Q-loop/lid; other site 226900012786 ABC transporter signature motif; other site 226900012787 Walker B; other site 226900012788 D-loop; other site 226900012789 H-loop/switch region; other site 226900012790 Cytochrome c; Region: Cytochrom_C; cl11414 226900012791 peptide chain release factor 2; Provisional; Region: PRK06746 226900012792 RF-1 domain; Region: RF-1; cl02875 226900012793 RF-1 domain; Region: RF-1; cl02875 226900012794 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 226900012795 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900012796 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 226900012797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900012798 nucleotide binding region [chemical binding]; other site 226900012799 ATP-binding site [chemical binding]; other site 226900012800 SEC-C motif; Region: SEC-C; pfam02810 226900012801 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 226900012802 30S subunit binding site; other site 226900012803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 226900012804 DNA-binding site [nucleotide binding]; DNA binding site 226900012805 RNA-binding motif; other site 226900012806 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 226900012807 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900012808 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 226900012809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900012810 ATP binding site [chemical binding]; other site 226900012811 putative Mg++ binding site [ion binding]; other site 226900012812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900012813 nucleotide binding region [chemical binding]; other site 226900012814 ATP-binding site [chemical binding]; other site 226900012815 Probable transposase; Region: OrfB_IS605; pfam01385 226900012816 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900012817 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900012818 Transposase IS200 like; Region: Y1_Tnp; cl00848 226900012819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 226900012820 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 226900012821 NlpC/P60 family; Region: NLPC_P60; cl11438 226900012822 Helix-turn-helix domains; Region: HTH; cl00088 226900012823 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 226900012824 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 226900012825 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 226900012826 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 226900012827 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900012828 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 226900012829 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226900012830 active site 226900012831 homodimer interface [polypeptide binding]; other site 226900012832 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 226900012833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012834 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226900012835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900012836 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 226900012837 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 226900012838 Mg++ binding site [ion binding]; other site 226900012839 putative catalytic motif [active] 226900012840 substrate binding site [chemical binding]; other site 226900012841 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900012842 NodB motif; other site 226900012843 active site 226900012844 catalytic site [active] 226900012845 Zn binding site [ion binding]; other site 226900012846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900012847 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226900012848 Walker A motif; other site 226900012849 ATP binding site [chemical binding]; other site 226900012850 Walker B motif; other site 226900012851 arginine finger; other site 226900012852 Transcriptional antiterminator [Transcription]; Region: COG3933 226900012853 PRD domain; Region: PRD; cl15445 226900012854 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226900012855 active pocket/dimerization site; other site 226900012856 active site 226900012857 phosphorylation site [posttranslational modification] 226900012858 PRD domain; Region: PRD; cl15445 226900012859 CHRD domain; Region: CHRD; cl06473 226900012860 Chromate transporter; Region: Chromate_transp; pfam02417 226900012861 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 226900012862 Chromate transporter; Region: Chromate_transp; pfam02417 226900012863 YdjC-like protein; Region: YdjC; cl01344 226900012864 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 226900012865 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 226900012866 NAD binding site [chemical binding]; other site 226900012867 sugar binding site [chemical binding]; other site 226900012868 divalent metal binding site [ion binding]; other site 226900012869 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900012870 dimer interface [polypeptide binding]; other site 226900012871 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900012872 active site 226900012873 methionine cluster; other site 226900012874 phosphorylation site [posttranslational modification] 226900012875 metal binding site [ion binding]; metal-binding site 226900012876 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900012877 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 226900012878 similar to PTS system, lichenan oligosaccharide-specific IIB component; EC_number 2.7.1.69 226900012879 spermidine synthase; Provisional; Region: PRK03612 226900012880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012881 S-adenosylmethionine binding site [chemical binding]; other site 226900012882 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 226900012883 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900012884 methionine cluster; other site 226900012885 active site 226900012886 phosphorylation site [posttranslational modification] 226900012887 metal binding site [ion binding]; metal-binding site 226900012888 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900012889 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900012890 active site 226900012891 P-loop; other site 226900012892 phosphorylation site [posttranslational modification] 226900012893 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900012894 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226900012895 OpgC protein; Region: OpgC_C; cl00792 226900012896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 226900012897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 226900012898 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900012899 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 226900012900 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 226900012901 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900012902 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 226900012903 Helix-turn-helix domains; Region: HTH; cl00088 226900012904 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 226900012905 putative dimerization interface [polypeptide binding]; other site 226900012906 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 226900012907 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900012908 arsenical pump membrane protein; Provisional; Region: PRK15445 226900012909 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 226900012910 transmembrane helices; other site 226900012911 ThiC family; Region: ThiC; cl08031 226900012912 L-lactate permease; Region: Lactate_perm; cl00701 226900012913 glycolate transporter; Provisional; Region: PRK09695 226900012914 Tic20-like protein; Region: Tic20; pfam09685 226900012915 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 226900012916 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 226900012917 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900012918 Sulfatase; Region: Sulfatase; cl10460 226900012919 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900012920 homodimer interface [polypeptide binding]; other site 226900012921 substrate-cofactor binding pocket; other site 226900012922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900012923 Aminotransferase class IV; Region: Aminotran_4; pfam01063 226900012924 catalytic residue [active] 226900012925 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012926 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012927 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012928 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012929 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012930 NlpC/P60 family; Region: NLPC_P60; cl11438 226900012931 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900012932 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900012933 Nucleoside recognition; Region: Gate; cl00486 226900012934 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900012935 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900012936 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226900012937 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 226900012938 DXD motif; other site 226900012939 BCCT family transporter; Region: BCCT; cl00569 226900012940 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012941 Bacterial SH3 domain; Region: SH3_3; cl02551 226900012942 3D domain; Region: 3D; cl01439 226900012943 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 226900012944 Predicted membrane protein [Function unknown]; Region: COG4640 226900012945 Double zinc ribbon; Region: DZR; pfam12773 226900012946 Double zinc ribbon; Region: DZR; pfam12773 226900012947 SNF2 Helicase protein; Region: DUF3670; pfam12419 226900012948 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226900012949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900012950 ATP binding site [chemical binding]; other site 226900012951 putative Mg++ binding site [ion binding]; other site 226900012952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900012953 nucleotide binding region [chemical binding]; other site 226900012954 ATP-binding site [chemical binding]; other site 226900012955 VanZ like family; Region: VanZ; cl01971 226900012956 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 226900012957 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 226900012958 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 226900012959 ComK protein; Region: ComK; cl11560 226900012960 RNA polymerase factor sigma-70; Validated; Region: PRK06759 226900012961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900012962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900012963 DNA binding residues [nucleotide binding] 226900012964 Yip1 domain; Region: Yip1; cl12048 226900012965 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900012966 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226900012967 FtsX-like permease family; Region: FtsX; pfam02687 226900012968 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012969 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 226900012970 Walker A/P-loop; other site 226900012971 ATP binding site [chemical binding]; other site 226900012972 Q-loop/lid; other site 226900012973 ABC transporter signature motif; other site 226900012974 Walker B; other site 226900012975 D-loop; other site 226900012976 H-loop/switch region; other site 226900012977 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226900012978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900012979 non-specific DNA binding site [nucleotide binding]; other site 226900012980 salt bridge; other site 226900012981 sequence-specific DNA binding site [nucleotide binding]; other site 226900012982 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 226900012983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012984 putative substrate translocation pore; other site 226900012985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900012986 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 226900012987 sensory histidine kinase CreC; Provisional; Region: PRK11100 226900012988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012989 dimerization interface [polypeptide binding]; other site 226900012990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012991 dimer interface [polypeptide binding]; other site 226900012992 phosphorylation site [posttranslational modification] 226900012993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012994 ATP binding site [chemical binding]; other site 226900012995 Mg2+ binding site [ion binding]; other site 226900012996 G-X-G motif; other site 226900012997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012999 active site 226900013000 phosphorylation site [posttranslational modification] 226900013001 intermolecular recognition site; other site 226900013002 dimerization interface [polypeptide binding]; other site 226900013003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900013004 DNA binding site [nucleotide binding] 226900013005 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 226900013006 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226900013007 NAD binding site [chemical binding]; other site 226900013008 homodimer interface [polypeptide binding]; other site 226900013009 active site 226900013010 substrate binding site [chemical binding]; other site 226900013011 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226900013012 active site 226900013013 catalytic triad [active] 226900013014 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900013015 putative diguanylate cyclase; Provisional; Region: PRK09776 226900013016 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900013017 active site 226900013018 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 226900013019 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 226900013020 Bacterial sugar transferase; Region: Bac_transf; cl00939 226900013021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900013022 extended (e) SDRs; Region: SDR_e; cd08946 226900013023 NAD(P) binding site [chemical binding]; other site 226900013024 active site 226900013025 substrate binding site [chemical binding]; other site 226900013026 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 226900013027 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 226900013028 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 226900013029 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226900013030 inhibitor-cofactor binding pocket; inhibition site 226900013031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900013032 catalytic residue [active] 226900013033 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 226900013034 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226900013035 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226900013036 NAD(P) binding site [chemical binding]; other site 226900013037 homodimer interface [polypeptide binding]; other site 226900013038 substrate binding site [chemical binding]; other site 226900013039 active site 226900013040 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 226900013041 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 226900013042 active site 226900013043 tetramer interface; other site 226900013044 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 226900013045 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900013046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900013047 Chain length determinant protein; Region: Wzz; cl01623 226900013048 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900013049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900013050 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226900013051 rod shape-determining protein Mbl; Provisional; Region: PRK13928 226900013052 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 226900013053 ATP binding site [chemical binding]; other site 226900013054 profilin binding site; other site 226900013055 Helix-turn-helix domains; Region: HTH; cl00088 226900013056 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900013057 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900013058 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900013059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900013060 Walker A/P-loop; other site 226900013061 ATP binding site [chemical binding]; other site 226900013062 Q-loop/lid; other site 226900013063 ABC transporter signature motif; other site 226900013064 Walker B; other site 226900013065 D-loop; other site 226900013066 H-loop/switch region; other site 226900013067 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226900013068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 226900013069 Walker A/P-loop; other site 226900013070 ATP binding site [chemical binding]; other site 226900013071 Q-loop/lid; other site 226900013072 ABC transporter signature motif; other site 226900013073 Walker B; other site 226900013074 D-loop; other site 226900013075 H-loop/switch region; other site 226900013076 LytTr DNA-binding domain; Region: LytTR; cl04498 226900013077 stage II sporulation protein D; Region: spore_II_D; TIGR02870 226900013078 Stage II sporulation protein; Region: SpoIID; pfam08486 226900013079 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226900013080 hinge; other site 226900013081 active site 226900013082 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 226900013083 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 226900013084 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 226900013085 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 226900013086 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 226900013087 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 226900013088 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 226900013089 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 226900013090 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 226900013091 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 226900013092 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 226900013093 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 226900013094 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 226900013095 4Fe-4S binding domain; Region: Fer4; cl02805 226900013096 4Fe-4S binding domain; Region: Fer4; cl02805 226900013097 NADH dehydrogenase; Region: NADHdh; cl00469 226900013098 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 226900013099 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 226900013100 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 226900013101 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 226900013102 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 226900013103 PAS domain S-box; Region: sensory_box; TIGR00229 226900013104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900013105 putative active site [active] 226900013106 heme pocket [chemical binding]; other site 226900013107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900013108 metal binding site [ion binding]; metal-binding site 226900013109 active site 226900013110 I-site; other site 226900013111 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900013112 Protein of unknown function (DUF975); Region: DUF975; cl10504 226900013113 similar to Integral membrane protein 226900013114 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 226900013115 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 226900013116 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 226900013117 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 226900013118 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 226900013119 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 226900013120 alpha subunit interaction interface [polypeptide binding]; other site 226900013121 Walker A motif; other site 226900013122 ATP binding site [chemical binding]; other site 226900013123 Walker B motif; other site 226900013124 inhibitor binding site; inhibition site 226900013125 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226900013126 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 226900013127 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 226900013128 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 226900013129 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 226900013130 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 226900013131 beta subunit interaction interface [polypeptide binding]; other site 226900013132 Walker A motif; other site 226900013133 ATP binding site [chemical binding]; other site 226900013134 Walker B motif; other site 226900013135 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226900013136 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 226900013137 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 226900013138 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 226900013139 ATP synthase subunit C; Region: ATP-synt_C; cl00466 226900013140 ATP synthase A chain; Region: ATP-synt_A; cl00413 226900013141 ATP synthase I chain; Region: ATP_synt_I; cl09170 226900013142 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 226900013143 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 226900013144 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 226900013145 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 226900013146 dimer interface [polypeptide binding]; other site 226900013147 glycine-pyridoxal phosphate binding site [chemical binding]; other site 226900013148 active site 226900013149 folate binding site [chemical binding]; other site 226900013150 Protein of unknown function (DUF436); Region: DUF436; cl01860 226900013151 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 226900013152 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900013153 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 226900013154 active site 226900013155 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 226900013156 HPr interaction site; other site 226900013157 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226900013158 active site 226900013159 phosphorylation site [posttranslational modification] 226900013160 DoxX; Region: DoxX; cl00976 226900013161 Flavin Reductases; Region: FlaRed; cl00801 226900013162 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 226900013163 Domain of unknown function DUF; Region: DUF204; pfam02659 226900013164 Domain of unknown function DUF; Region: DUF204; pfam02659 226900013165 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 226900013166 SUA5 domain; Region: SUA5; pfam03481 226900013167 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 226900013168 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 226900013169 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 226900013170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013171 S-adenosylmethionine binding site [chemical binding]; other site 226900013172 peptide chain release factor 1; Validated; Region: prfA; PRK00591 226900013173 RF-1 domain; Region: RF-1; cl02875 226900013174 RF-1 domain; Region: RF-1; cl02875 226900013175 Thymidine kinase; Region: TK; cl00631 226900013176 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 226900013177 transcription termination factor Rho; Provisional; Region: rho; PRK09376 226900013178 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 226900013179 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 226900013180 RNA binding site [nucleotide binding]; other site 226900013181 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 226900013182 multimer interface [polypeptide binding]; other site 226900013183 Walker A motif; other site 226900013184 ATP binding site [chemical binding]; other site 226900013185 Walker B motif; other site 226900013186 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 226900013187 putative active site [active] 226900013188 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226900013189 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 226900013190 hinge; other site 226900013191 active site 226900013192 hypothetical protein; Provisional; Region: PRK08185 226900013193 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 226900013194 intersubunit interface [polypeptide binding]; other site 226900013195 active site 226900013196 zinc binding site [ion binding]; other site 226900013197 Na+ binding site [ion binding]; other site 226900013198 Response regulator receiver domain; Region: Response_reg; pfam00072 226900013199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013200 active site 226900013201 phosphorylation site [posttranslational modification] 226900013202 intermolecular recognition site; other site 226900013203 dimerization interface [polypeptide binding]; other site 226900013204 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 226900013205 CTP synthetase; Validated; Region: pyrG; PRK05380 226900013206 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 226900013207 Catalytic site [active] 226900013208 active site 226900013209 UTP binding site [chemical binding]; other site 226900013210 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 226900013211 active site 226900013212 putative oxyanion hole; other site 226900013213 catalytic triad [active] 226900013214 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 226900013215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900013216 Helix-turn-helix domains; Region: HTH; cl00088 226900013217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900013218 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 226900013219 FAD binding site [chemical binding]; other site 226900013220 homotetramer interface [polypeptide binding]; other site 226900013221 substrate binding pocket [chemical binding]; other site 226900013222 catalytic base [active] 226900013223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900013224 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 226900013225 FAD binding site [chemical binding]; other site 226900013226 homotetramer interface [polypeptide binding]; other site 226900013227 substrate binding pocket [chemical binding]; other site 226900013228 catalytic base [active] 226900013229 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 226900013230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 226900013231 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900013232 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 226900013233 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900013234 dimer interface [polypeptide binding]; other site 226900013235 active site 226900013236 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 226900013237 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 226900013238 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 226900013239 Cysteine-rich domain; Region: CCG; pfam02754 226900013240 Cysteine-rich domain; Region: CCG; pfam02754 226900013241 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900013242 putative active site [active] 226900013243 catalytic site [active] 226900013244 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900013245 putative active site [active] 226900013246 catalytic site [active] 226900013247 UV-endonuclease UvdE; Region: UvdE; cl10036 226900013248 similar to Sensory box/GGDEF family protein 226900013249 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 226900013250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900013251 non-specific DNA binding site [nucleotide binding]; other site 226900013252 salt bridge; other site 226900013253 sequence-specific DNA binding site [nucleotide binding]; other site 226900013254 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900013255 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900013256 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900013257 active site 226900013258 Zn binding site [ion binding]; other site 226900013259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013260 active site 226900013261 phosphorylation site [posttranslational modification] 226900013262 intermolecular recognition site; other site 226900013263 dimerization interface [polypeptide binding]; other site 226900013264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900013265 DNA binding residues [nucleotide binding] 226900013266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900013267 Histidine kinase; Region: HisKA_3; pfam07730 226900013268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226900013269 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900013270 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900013271 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 226900013272 Walker A/P-loop; other site 226900013273 ATP binding site [chemical binding]; other site 226900013274 Q-loop/lid; other site 226900013275 ABC transporter signature motif; other site 226900013276 Walker B; other site 226900013277 D-loop; other site 226900013278 H-loop/switch region; other site 226900013279 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900013280 active site 226900013281 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 226900013282 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013283 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013284 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013285 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013286 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013287 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013288 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013289 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013290 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013291 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013292 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013293 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013294 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013295 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013296 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013297 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013298 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013299 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013300 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013301 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 226900013302 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 226900013303 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 226900013304 PA/protease or protease-like domain interface [polypeptide binding]; other site 226900013305 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 226900013306 metal binding site [ion binding]; metal-binding site 226900013307 RNA polymerase sigma factor; Provisional; Region: PRK12522 226900013308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900013309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900013310 DNA binding residues [nucleotide binding] 226900013311 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 226900013312 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 226900013313 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 226900013314 active site 226900013315 HIGH motif; other site 226900013316 KMSK motif region; other site 226900013317 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226900013318 tRNA binding surface [nucleotide binding]; other site 226900013319 anticodon binding site; other site 226900013320 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 226900013321 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900013322 putative dimer interface [polypeptide binding]; other site 226900013323 catalytic triad [active] 226900013324 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900013325 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 226900013326 Arginase family; Region: Arginase; cl00306 226900013327 spermidine synthase; Provisional; Region: PRK00811 226900013328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013329 S-adenosylmethionine binding site [chemical binding]; other site 226900013330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900013332 putative substrate translocation pore; other site 226900013333 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900013334 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 226900013335 DNA binding residues [nucleotide binding] 226900013336 putative dimer interface [polypeptide binding]; other site 226900013337 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 226900013338 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 226900013339 active site 226900013340 catalytic site [active] 226900013341 metal binding site [ion binding]; metal-binding site 226900013342 dimer interface [polypeptide binding]; other site 226900013343 Transglycosylase; Region: Transgly; cl07896 226900013344 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900013345 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900013346 YwhD family; Region: YwhD; pfam08741 226900013347 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 226900013348 active site 226900013349 putative substrate binding region [chemical binding]; other site 226900013350 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 226900013351 active site 1 [active] 226900013352 dimer interface [polypeptide binding]; other site 226900013353 hexamer interface [polypeptide binding]; other site 226900013354 active site 2 [active] 226900013355 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 226900013356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900013357 Zn2+ binding site [ion binding]; other site 226900013358 Mg2+ binding site [ion binding]; other site 226900013359 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226900013360 intersubunit interface [polypeptide binding]; other site 226900013361 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900013362 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900013363 Walker A/P-loop; other site 226900013364 ATP binding site [chemical binding]; other site 226900013365 Q-loop/lid; other site 226900013366 ABC transporter signature motif; other site 226900013367 Walker B; other site 226900013368 D-loop; other site 226900013369 H-loop/switch region; other site 226900013370 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 226900013371 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900013372 ABC-ATPase subunit interface; other site 226900013373 dimer interface [polypeptide binding]; other site 226900013374 putative PBP binding regions; other site 226900013375 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 226900013376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900013377 ABC-ATPase subunit interface; other site 226900013378 dimer interface [polypeptide binding]; other site 226900013379 putative PBP binding regions; other site 226900013380 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 226900013381 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 226900013382 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 226900013383 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226900013384 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 226900013385 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 226900013386 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 226900013387 Chlorite dismutase; Region: Chlor_dismutase; cl01280 226900013388 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900013389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 226900013390 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900013391 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900013392 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 226900013393 Protein of unknown function (DUF423); Region: DUF423; cl01008 226900013394 Ion channel; Region: Ion_trans_2; cl11596 226900013395 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900013396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900013397 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 226900013398 Permease family; Region: Xan_ur_permease; cl00967 226900013399 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900013400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900013401 motif II; other site 226900013402 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 226900013403 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 226900013404 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 226900013405 ligand binding site [chemical binding]; other site 226900013406 active site 226900013407 UGI interface [polypeptide binding]; other site 226900013408 catalytic site [active] 226900013409 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 226900013410 ABC-2 type transporter; Region: ABC2_membrane; cl11417 226900013411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900013412 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 226900013413 Walker A/P-loop; other site 226900013414 ATP binding site [chemical binding]; other site 226900013415 Q-loop/lid; other site 226900013416 ABC transporter signature motif; other site 226900013417 Walker B; other site 226900013418 D-loop; other site 226900013419 H-loop/switch region; other site 226900013420 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 226900013421 active site 226900013422 catalytic triad [active] 226900013423 oxyanion hole [active] 226900013424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900013425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900013426 DNA binding site [nucleotide binding] 226900013427 domain linker motif; other site 226900013428 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900013429 putative dimerization interface [polypeptide binding]; other site 226900013430 putative ligand binding site [chemical binding]; other site 226900013431 Predicted membrane protein [Function unknown]; Region: COG2364 226900013432 homoserine dehydrogenase; Provisional; Region: PRK06349 226900013433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900013434 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900013435 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 226900013436 Homoserine O-succinyltransferase; Region: HTS; pfam04204 226900013437 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 226900013438 proposed active site lysine [active] 226900013439 conserved cys residue [active] 226900013440 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 226900013441 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900013442 homodimer interface [polypeptide binding]; other site 226900013443 substrate-cofactor binding pocket; other site 226900013444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900013445 catalytic residue [active] 226900013446 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 226900013447 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 226900013448 Cl- selectivity filter; other site 226900013449 Cl- binding residues [ion binding]; other site 226900013450 pore gating glutamate residue; other site 226900013451 dimer interface [polypeptide binding]; other site 226900013452 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226900013453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900013454 motif I; other site 226900013455 motif II; other site 226900013456 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900013457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900013458 ligand binding site [chemical binding]; other site 226900013459 flexible hinge region; other site 226900013460 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226900013461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900013462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013463 active site 226900013464 phosphorylation site [posttranslational modification] 226900013465 intermolecular recognition site; other site 226900013466 dimerization interface [polypeptide binding]; other site 226900013467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900013468 DNA binding residues [nucleotide binding] 226900013469 dimerization interface [polypeptide binding]; other site 226900013470 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 226900013471 GAF domain; Region: GAF; cl00853 226900013472 GAF domain; Region: GAF; cl00853 226900013473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 226900013474 Histidine kinase; Region: HisKA_3; pfam07730 226900013475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226900013476 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226900013477 dimer interface [polypeptide binding]; other site 226900013478 substrate binding site [chemical binding]; other site 226900013479 ATP binding site [chemical binding]; other site 226900013480 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900013481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900013482 metal binding site [ion binding]; metal-binding site 226900013483 active site 226900013484 I-site; other site 226900013485 Protein of unknown function (DUF466); Region: DUF466; cl01082 226900013486 Carbon starvation protein CstA; Region: CstA; cl00856 226900013487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013488 active site 226900013489 phosphorylation site [posttranslational modification] 226900013490 intermolecular recognition site; other site 226900013491 dimerization interface [polypeptide binding]; other site 226900013492 LytTr DNA-binding domain; Region: LytTR; cl04498 226900013493 benzoate transport; Region: 2A0115; TIGR00895 226900013494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013495 putative substrate translocation pore; other site 226900013496 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 226900013497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900013498 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226900013499 Predicted membrane protein [Function unknown]; Region: COG2860 226900013500 UPF0126 domain; Region: UPF0126; pfam03458 226900013501 UPF0126 domain; Region: UPF0126; pfam03458 226900013502 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 226900013503 heme-binding site [chemical binding]; other site 226900013504 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 226900013505 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 226900013506 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 226900013507 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226900013508 Ligand binding site; other site 226900013509 Putative Catalytic site; other site 226900013510 DXD motif; other site 226900013511 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 226900013512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900013513 active site 226900013514 MatE; Region: MatE; cl10513 226900013515 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 226900013516 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 226900013517 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 226900013518 Ligand binding site; other site 226900013519 Putative Catalytic site; other site 226900013520 DXD motif; other site 226900013521 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900013522 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900013523 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900013524 ABC transporter; Region: ABC_tran_2; pfam12848 226900013525 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 226900013526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900013527 Helix-turn-helix domains; Region: HTH; cl00088 226900013528 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226900013529 Protein export membrane protein; Region: SecD_SecF; cl14618 226900013530 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 226900013531 SelR domain; Region: SelR; cl00369 226900013532 Domain of unknown function DUF20; Region: UPF0118; cl00465 226900013533 LrgB-like family; Region: LrgB; cl00596 226900013534 LrgA family; Region: LrgA; cl00608 226900013535 two-component response regulator; Provisional; Region: PRK14084 226900013536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013537 active site 226900013538 phosphorylation site [posttranslational modification] 226900013539 intermolecular recognition site; other site 226900013540 dimerization interface [polypeptide binding]; other site 226900013541 LytTr DNA-binding domain; Region: LytTR; cl04498 226900013542 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 226900013543 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 226900013544 GAF domain; Region: GAF; cl00853 226900013545 Histidine kinase; Region: His_kinase; pfam06580 226900013546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900013547 ATP binding site [chemical binding]; other site 226900013548 Mg2+ binding site [ion binding]; other site 226900013549 G-X-G motif; other site 226900013550 benzoate transport; Region: 2A0115; TIGR00895 226900013551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013552 putative substrate translocation pore; other site 226900013553 BCCT family transporter; Region: BCCT; cl00569 226900013554 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 226900013555 active site 226900013556 dimer interface [polypeptide binding]; other site 226900013557 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900013558 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900013559 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900013560 similar to Isoflavone reductase 226900013561 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 226900013562 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226900013563 UDP-glucose 4-epimerase; Region: PLN02240 226900013564 NAD binding site [chemical binding]; other site 226900013565 homodimer interface [polypeptide binding]; other site 226900013566 active site 226900013567 substrate binding site [chemical binding]; other site 226900013568 Haemolysin-III related; Region: HlyIII; cl03831 226900013569 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 226900013570 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 226900013571 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900013572 ATP binding site [chemical binding]; other site 226900013573 Mg++ binding site [ion binding]; other site 226900013574 motif III; other site 226900013575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900013576 nucleotide binding region [chemical binding]; other site 226900013577 ATP-binding site [chemical binding]; other site 226900013578 DbpA RNA binding domain; Region: DbpA; pfam03880 226900013579 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 226900013580 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 226900013581 active site 226900013582 oligoendopeptidase F; Region: pepF; TIGR00181 226900013583 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 226900013584 active site 226900013585 Zn binding site [ion binding]; other site 226900013586 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 226900013587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900013588 FeS/SAM binding site; other site 226900013589 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900013590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900013591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900013592 dimer interface [polypeptide binding]; other site 226900013593 phosphorylation site [posttranslational modification] 226900013594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900013595 ATP binding site [chemical binding]; other site 226900013596 Mg2+ binding site [ion binding]; other site 226900013597 G-X-G motif; other site 226900013598 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 226900013599 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 226900013600 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 226900013601 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 226900013602 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900013603 protein binding site [polypeptide binding]; other site 226900013604 similar to Zn-dependent hydrolase (beta-lactamase superfamily) 226900013605 YycH protein; Region: YycI; cl02015 226900013606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 226900013607 YycH protein; Region: YycH; pfam07435 226900013608 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226900013609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900013610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900013611 dimerization interface [polypeptide binding]; other site 226900013612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 226900013613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900013614 dimer interface [polypeptide binding]; other site 226900013615 phosphorylation site [posttranslational modification] 226900013616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900013617 ATP binding site [chemical binding]; other site 226900013618 Mg2+ binding site [ion binding]; other site 226900013619 G-X-G motif; other site 226900013620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900013621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013622 active site 226900013623 phosphorylation site [posttranslational modification] 226900013624 intermolecular recognition site; other site 226900013625 dimerization interface [polypeptide binding]; other site 226900013626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900013627 DNA binding site [nucleotide binding] 226900013628 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 226900013629 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 226900013630 GDP-binding site [chemical binding]; other site 226900013631 ACT binding site; other site 226900013632 IMP binding site; other site 226900013633 similar to Replicative DNA helicase; EC_number 3.6.1.- 226900013634 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 226900013635 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 226900013636 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 226900013637 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 226900013638 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900013639 DHH family; Region: DHH; pfam01368 226900013640 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 226900013641 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 226900013642 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226900013643 dimer interface [polypeptide binding]; other site 226900013644 ssDNA binding site [nucleotide binding]; other site 226900013645 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900013646 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 226900013647 GTP-binding protein YchF; Reviewed; Region: PRK09601 226900013648 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 226900013649 G1 box; other site 226900013650 GTP/Mg2+ binding site [chemical binding]; other site 226900013651 Switch I region; other site 226900013652 G2 box; other site 226900013653 Switch II region; other site 226900013654 G3 box; other site 226900013655 G4 box; other site 226900013656 G5 box; other site 226900013657 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 226900013658 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 226900013659 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226900013660 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 226900013661 ParB-like partition proteins; Region: parB_part; TIGR00180 226900013662 ParB-like nuclease domain; Region: ParBc; cl02129 226900013663 KorB domain; Region: KorB; pfam08535 226900013664 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226900013665 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226900013666 P-loop; other site 226900013667 Magnesium ion binding site [ion binding]; other site 226900013668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226900013669 Magnesium ion binding site [ion binding]; other site 226900013670 ParB-like partition proteins; Region: parB_part; TIGR00180 226900013671 ParB-like nuclease domain; Region: ParBc; cl02129 226900013672 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 226900013673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013674 S-adenosylmethionine binding site [chemical binding]; other site 226900013675 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 226900013676 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 226900013677 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 226900013678 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 226900013679 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 226900013680 G1 box; other site 226900013681 GTP/Mg2+ binding site [chemical binding]; other site 226900013682 Switch I region; other site 226900013683 G2 box; other site 226900013684 Switch II region; other site 226900013685 G3 box; other site 226900013686 G4 box; other site 226900013687 G5 box; other site 226900013688 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 226900013689 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 226900013690 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 226900013691 G-X-X-G motif; other site 226900013692 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 226900013693 RxxxH motif; other site 226900013694 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 226900013695 Ribonuclease P; Region: Ribonuclease_P; cl00457 226900013696 Ribosomal protein L34; Region: Ribosomal_L34; cl00370