-- dump date 20120504_134012 -- class Genbank::misc_feature -- table misc_feature_note -- id note 288681000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 288681000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000004 Walker A motif; other site 288681000005 ATP binding site [chemical binding]; other site 288681000006 Walker B motif; other site 288681000007 arginine finger; other site 288681000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 288681000009 DnaA box-binding interface [nucleotide binding]; other site 288681000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 288681000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 288681000012 putative DNA binding surface [nucleotide binding]; other site 288681000013 dimer interface [polypeptide binding]; other site 288681000014 beta-clamp/clamp loader binding surface; other site 288681000015 beta-clamp/translesion DNA polymerase binding surface; other site 288681000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 288681000017 recombination protein F; Reviewed; Region: recF; PRK00064 288681000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 288681000019 Walker A/P-loop; other site 288681000020 ATP binding site [chemical binding]; other site 288681000021 Q-loop/lid; other site 288681000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681000023 ABC transporter signature motif; other site 288681000024 Walker B; other site 288681000025 D-loop; other site 288681000026 H-loop/switch region; other site 288681000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 288681000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000029 Mg2+ binding site [ion binding]; other site 288681000030 G-X-G motif; other site 288681000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288681000032 anchoring element; other site 288681000033 dimer interface [polypeptide binding]; other site 288681000034 ATP binding site [chemical binding]; other site 288681000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 288681000036 active site 288681000037 putative metal-binding site [ion binding]; other site 288681000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288681000039 DNA gyrase subunit A; Validated; Region: PRK05560 288681000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 288681000041 CAP-like domain; other site 288681000042 active site 288681000043 primary dimer interface [polypeptide binding]; other site 288681000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000050 YaaC-like Protein; Region: YaaC; pfam14175 288681000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 288681000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 288681000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 288681000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 288681000055 active site 288681000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681000057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 288681000059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 288681000060 active site 288681000061 multimer interface [polypeptide binding]; other site 288681000062 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 288681000063 predicted active site [active] 288681000064 catalytic triad [active] 288681000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 288681000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 288681000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 288681000068 dimer interface [polypeptide binding]; other site 288681000069 active site 288681000070 motif 1; other site 288681000071 motif 2; other site 288681000072 motif 3; other site 288681000073 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 288681000074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 288681000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 288681000077 Substrate-binding site [chemical binding]; other site 288681000078 Substrate specificity [chemical binding]; other site 288681000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 288681000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 288681000081 Substrate-binding site [chemical binding]; other site 288681000082 Substrate specificity [chemical binding]; other site 288681000083 Isochorismatase family; Region: Isochorismatase; pfam00857 288681000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 288681000085 catalytic triad [active] 288681000086 conserved cis-peptide bond; other site 288681000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 288681000088 nucleoside/Zn binding site; other site 288681000089 dimer interface [polypeptide binding]; other site 288681000090 catalytic motif [active] 288681000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 288681000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000093 Walker A motif; other site 288681000094 ATP binding site [chemical binding]; other site 288681000095 Walker B motif; other site 288681000096 arginine finger; other site 288681000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 288681000098 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 288681000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 288681000100 RecR protein; Region: RecR; pfam02132 288681000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 288681000102 putative active site [active] 288681000103 putative metal-binding site [ion binding]; other site 288681000104 tetramer interface [polypeptide binding]; other site 288681000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 288681000106 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 288681000107 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 288681000108 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 288681000109 homodimer interface [polypeptide binding]; other site 288681000110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000111 catalytic residue [active] 288681000112 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 288681000113 thymidylate kinase; Validated; Region: tmk; PRK00698 288681000114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 288681000115 TMP-binding site; other site 288681000116 ATP-binding site [chemical binding]; other site 288681000117 DNA polymerase III subunit delta'; Validated; Region: PRK08058 288681000118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681000119 PSP1 C-terminal conserved region; Region: PSP1; cl00770 288681000120 TSC-22/dip/bun family; Region: TSC22; cl01853 288681000121 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 288681000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681000123 S-adenosylmethionine binding site [chemical binding]; other site 288681000124 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 288681000125 GIY-YIG motif/motif A; other site 288681000126 putative active site [active] 288681000127 putative metal binding site [ion binding]; other site 288681000128 Predicted methyltransferases [General function prediction only]; Region: COG0313 288681000129 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 288681000130 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681000131 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681000132 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 288681000133 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 288681000134 active site 288681000135 HIGH motif; other site 288681000136 KMSKS motif; other site 288681000137 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 288681000138 tRNA binding surface [nucleotide binding]; other site 288681000139 anticodon binding site; other site 288681000140 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 288681000141 dimer interface [polypeptide binding]; other site 288681000142 putative tRNA-binding site [nucleotide binding]; other site 288681000143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 288681000144 active site 288681000145 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 288681000146 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 288681000147 putative active site [active] 288681000148 putative metal binding site [ion binding]; other site 288681000149 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 288681000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681000151 YabG peptidase U57; Region: Peptidase_U57; cl05250 288681000152 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 288681000153 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 288681000154 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681000155 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681000156 pur operon repressor; Provisional; Region: PRK09213 288681000157 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 288681000158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000159 active site 288681000160 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288681000161 homotrimer interaction site [polypeptide binding]; other site 288681000162 putative active site [active] 288681000163 SpoVG; Region: SpoVG; cl00915 288681000164 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 288681000165 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 288681000166 Substrate binding site; other site 288681000167 Mg++ binding site; other site 288681000168 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 288681000169 active site 288681000170 substrate binding site [chemical binding]; other site 288681000171 CoA binding site [chemical binding]; other site 288681000172 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 288681000173 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 288681000174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000175 active site 288681000176 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 288681000177 putative active site [active] 288681000178 catalytic residue [active] 288681000179 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 288681000180 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 288681000181 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 288681000182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681000183 ATP binding site [chemical binding]; other site 288681000184 putative Mg++ binding site [ion binding]; other site 288681000185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681000186 nucleotide binding region [chemical binding]; other site 288681000187 ATP-binding site [chemical binding]; other site 288681000188 TRCF domain; Region: TRCF; cl04088 288681000189 stage V sporulation protein T; Region: spore_V_T; TIGR02851 288681000190 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681000191 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681000192 MatE; Region: MatE; cl10513 288681000193 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 288681000194 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 288681000195 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 288681000196 homodimer interface [polypeptide binding]; other site 288681000197 metal binding site [ion binding]; metal-binding site 288681000198 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 288681000199 homodimer interface [polypeptide binding]; other site 288681000200 active site 288681000201 putative chemical substrate binding site [chemical binding]; other site 288681000202 metal binding site [ion binding]; metal-binding site 288681000203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681000204 RNA binding surface [nucleotide binding]; other site 288681000205 YabP family; Region: YabP; cl06766 288681000206 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 288681000207 Septum formation initiator; Region: DivIC; cl11433 288681000208 hypothetical protein; Provisional; Region: PRK08582 288681000209 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 288681000210 RNA binding site [nucleotide binding]; other site 288681000211 stage II sporulation protein E; Region: spore_II_E; TIGR02865 288681000212 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681000213 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 288681000214 Ligand Binding Site [chemical binding]; other site 288681000215 TilS substrate binding domain; Region: TilS; pfam09179 288681000216 B3/4 domain; Region: B3_4; cl11458 288681000217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000218 active site 288681000219 FtsH Extracellular; Region: FtsH_ext; pfam06480 288681000220 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 288681000221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000222 Walker A motif; other site 288681000223 ATP binding site [chemical binding]; other site 288681000224 Walker B motif; other site 288681000225 arginine finger; other site 288681000226 Peptidase family M41; Region: Peptidase_M41; pfam01434 288681000227 Type III pantothenate kinase; Region: Pan_kinase; cl09130 288681000228 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 288681000229 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 288681000230 dimerization interface [polypeptide binding]; other site 288681000231 domain crossover interface; other site 288681000232 redox-dependent activation switch; other site 288681000233 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288681000234 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681000235 dimer interface [polypeptide binding]; other site 288681000236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000237 catalytic residue [active] 288681000238 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 288681000239 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288681000240 chorismate binding enzyme; Region: Chorismate_bind; cl10555 288681000241 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 288681000242 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 288681000243 glutamine binding [chemical binding]; other site 288681000244 catalytic triad [active] 288681000245 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 288681000246 homodimer interface [polypeptide binding]; other site 288681000247 substrate-cofactor binding pocket; other site 288681000248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000249 catalytic residue [active] 288681000250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 288681000251 dihydropteroate synthase; Region: DHPS; TIGR01496 288681000252 substrate binding pocket [chemical binding]; other site 288681000253 dimer interface [polypeptide binding]; other site 288681000254 inhibitor binding site; inhibition site 288681000255 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 288681000256 homooctamer interface [polypeptide binding]; other site 288681000257 active site 288681000258 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 288681000259 catalytic center binding site [active] 288681000260 ATP binding site [chemical binding]; other site 288681000261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681000262 non-specific DNA binding site [nucleotide binding]; other site 288681000263 salt bridge; other site 288681000264 sequence-specific DNA binding site [nucleotide binding]; other site 288681000265 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 288681000266 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 288681000267 FMN binding site [chemical binding]; other site 288681000268 active site 288681000269 catalytic residues [active] 288681000270 substrate binding site [chemical binding]; other site 288681000271 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 288681000272 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 288681000273 dimer interface [polypeptide binding]; other site 288681000274 putative anticodon binding site; other site 288681000275 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 288681000276 motif 1; other site 288681000277 active site 288681000278 motif 2; other site 288681000279 motif 3; other site 288681000280 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 288681000281 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 288681000282 UvrB/uvrC motif; Region: UVR; pfam02151 288681000283 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 288681000284 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 288681000285 ADP binding site [chemical binding]; other site 288681000286 phosphagen binding site; other site 288681000287 substrate specificity loop; other site 288681000288 Clp protease ATP binding subunit; Region: clpC; CHL00095 288681000289 Clp amino terminal domain; Region: Clp_N; pfam02861 288681000290 Clp amino terminal domain; Region: Clp_N; pfam02861 288681000291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000292 Walker A motif; other site 288681000293 ATP binding site [chemical binding]; other site 288681000294 Walker B motif; other site 288681000295 arginine finger; other site 288681000296 UvrB/uvrC motif; Region: UVR; pfam02151 288681000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000298 Walker A motif; other site 288681000299 ATP binding site [chemical binding]; other site 288681000300 Walker B motif; other site 288681000301 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 288681000302 DNA repair protein RadA; Provisional; Region: PRK11823 288681000303 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 288681000304 Walker A motif/ATP binding site; other site 288681000305 ATP binding site [chemical binding]; other site 288681000306 Walker B motif; other site 288681000307 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 288681000308 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 288681000309 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681000310 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 288681000311 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 288681000312 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 288681000313 putative active site [active] 288681000314 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 288681000315 substrate binding site; other site 288681000316 dimer interface; other site 288681000317 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 288681000318 homotrimer interaction site [polypeptide binding]; other site 288681000319 zinc binding site [ion binding]; other site 288681000320 CDP-binding sites; other site 288681000321 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 288681000322 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 288681000323 active site 288681000324 HIGH motif; other site 288681000325 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 288681000326 active site 288681000327 KMSKS motif; other site 288681000328 serine O-acetyltransferase; Region: cysE; TIGR01172 288681000329 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 288681000330 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 288681000331 trimer interface [polypeptide binding]; other site 288681000332 active site 288681000333 substrate binding site [chemical binding]; other site 288681000334 CoA binding site [chemical binding]; other site 288681000335 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 288681000336 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 288681000337 active site 288681000338 HIGH motif; other site 288681000339 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 288681000340 KMSKS motif; other site 288681000341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 288681000342 tRNA binding surface [nucleotide binding]; other site 288681000343 anticodon binding site; other site 288681000344 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 288681000345 active site 288681000346 metal binding site [ion binding]; metal-binding site 288681000347 dimerization interface [polypeptide binding]; other site 288681000348 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 288681000349 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 288681000350 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 288681000351 YacP-like NYN domain; Region: NYN_YacP; cl01491 288681000352 RNA polymerase factor sigma-70; Validated; Region: PRK08295 288681000353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681000354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681000355 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 288681000356 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 288681000357 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 288681000358 putative homodimer interface [polypeptide binding]; other site 288681000359 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 288681000360 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 288681000361 23S rRNA interface [nucleotide binding]; other site 288681000362 L7/L12 interface [polypeptide binding]; other site 288681000363 putative thiostrepton binding site; other site 288681000364 L25 interface [polypeptide binding]; other site 288681000365 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 288681000366 mRNA/rRNA interface [nucleotide binding]; other site 288681000367 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 288681000368 23S rRNA interface [nucleotide binding]; other site 288681000369 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 288681000370 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 288681000371 core dimer interface [polypeptide binding]; other site 288681000372 peripheral dimer interface [polypeptide binding]; other site 288681000373 L10 interface [polypeptide binding]; other site 288681000374 L11 interface [polypeptide binding]; other site 288681000375 putative EF-Tu interaction site [polypeptide binding]; other site 288681000376 putative EF-G interaction site [polypeptide binding]; other site 288681000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681000378 S-adenosylmethionine binding site [chemical binding]; other site 288681000379 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 288681000380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 288681000381 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 288681000382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 288681000383 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 288681000384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 288681000385 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 288681000386 RPB10 interaction site [polypeptide binding]; other site 288681000387 RPB1 interaction site [polypeptide binding]; other site 288681000388 RPB11 interaction site [polypeptide binding]; other site 288681000389 RPB3 interaction site [polypeptide binding]; other site 288681000390 RPB12 interaction site [polypeptide binding]; other site 288681000391 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 288681000392 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 288681000393 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 288681000394 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 288681000395 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 288681000396 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 288681000397 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 288681000398 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 288681000399 G-loop; other site 288681000400 DNA binding site [nucleotide binding] 288681000401 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 288681000402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 288681000403 S17 interaction site [polypeptide binding]; other site 288681000404 S8 interaction site; other site 288681000405 16S rRNA interaction site [nucleotide binding]; other site 288681000406 streptomycin interaction site [chemical binding]; other site 288681000407 23S rRNA interaction site [nucleotide binding]; other site 288681000408 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 288681000409 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 288681000410 elongation factor G; Reviewed; Region: PRK00007 288681000411 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 288681000412 G1 box; other site 288681000413 putative GEF interaction site [polypeptide binding]; other site 288681000414 GTP/Mg2+ binding site [chemical binding]; other site 288681000415 Switch I region; other site 288681000416 G2 box; other site 288681000417 G3 box; other site 288681000418 Switch II region; other site 288681000419 G4 box; other site 288681000420 G5 box; other site 288681000421 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 288681000422 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 288681000423 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 288681000424 elongation factor Tu; Reviewed; Region: PRK00049 288681000425 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 288681000426 G1 box; other site 288681000427 GEF interaction site [polypeptide binding]; other site 288681000428 GTP/Mg2+ binding site [chemical binding]; other site 288681000429 Switch I region; other site 288681000430 G2 box; other site 288681000431 G3 box; other site 288681000432 Switch II region; other site 288681000433 G4 box; other site 288681000434 G5 box; other site 288681000435 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 288681000436 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 288681000437 Antibiotic Binding Site [chemical binding]; other site 288681000438 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 288681000439 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 288681000440 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 288681000441 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 288681000442 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 288681000443 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 288681000444 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 288681000445 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 288681000446 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 288681000447 putative translocon binding site; other site 288681000448 protein-rRNA interface [nucleotide binding]; other site 288681000449 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 288681000450 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 288681000451 G-X-X-G motif; other site 288681000452 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 288681000453 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 288681000454 23S rRNA interface [nucleotide binding]; other site 288681000455 5S rRNA interface [nucleotide binding]; other site 288681000456 putative antibiotic binding site [chemical binding]; other site 288681000457 L25 interface [polypeptide binding]; other site 288681000458 L27 interface [polypeptide binding]; other site 288681000459 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 288681000460 23S rRNA interface [nucleotide binding]; other site 288681000461 putative translocon interaction site; other site 288681000462 signal recognition particle (SRP54) interaction site; other site 288681000463 L23 interface [polypeptide binding]; other site 288681000464 trigger factor interaction site; other site 288681000465 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 288681000466 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 288681000467 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 288681000468 KOW motif; Region: KOW; cl00354 288681000469 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 288681000470 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 288681000471 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 288681000472 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 288681000473 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 288681000474 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 288681000475 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288681000476 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288681000477 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 288681000478 5S rRNA interface [nucleotide binding]; other site 288681000479 L27 interface [polypeptide binding]; other site 288681000480 23S rRNA interface [nucleotide binding]; other site 288681000481 L5 interface [polypeptide binding]; other site 288681000482 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 288681000483 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 288681000484 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 288681000485 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 288681000486 23S rRNA binding site [nucleotide binding]; other site 288681000487 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 288681000488 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 288681000489 SecY translocase; Region: SecY; pfam00344 288681000490 adenylate kinase; Reviewed; Region: adk; PRK00279 288681000491 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 288681000492 AMP-binding site [chemical binding]; other site 288681000493 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 288681000494 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681000495 active site 288681000496 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 288681000497 rRNA binding site [nucleotide binding]; other site 288681000498 predicted 30S ribosome binding site; other site 288681000499 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 288681000500 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 288681000501 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 288681000502 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 288681000503 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 288681000504 alphaNTD - beta interaction site [polypeptide binding]; other site 288681000505 alphaNTD homodimer interface [polypeptide binding]; other site 288681000506 alphaNTD - beta' interaction site [polypeptide binding]; other site 288681000507 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 288681000508 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 288681000509 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 288681000510 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 288681000511 Walker A/P-loop; other site 288681000512 ATP binding site [chemical binding]; other site 288681000513 Q-loop/lid; other site 288681000514 ABC transporter signature motif; other site 288681000515 Walker B; other site 288681000516 D-loop; other site 288681000517 H-loop/switch region; other site 288681000518 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 288681000519 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 288681000520 Walker A/P-loop; other site 288681000521 ATP binding site [chemical binding]; other site 288681000522 Q-loop/lid; other site 288681000523 ABC transporter signature motif; other site 288681000524 Walker B; other site 288681000525 D-loop; other site 288681000526 H-loop/switch region; other site 288681000527 Cobalt transport protein; Region: CbiQ; cl00463 288681000528 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 288681000529 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 288681000530 dimerization interface 3.5A [polypeptide binding]; other site 288681000531 active site 288681000532 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 288681000533 23S rRNA interface [nucleotide binding]; other site 288681000534 L3 interface [polypeptide binding]; other site 288681000535 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 288681000536 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 288681000537 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681000538 active site 288681000539 metal binding site [ion binding]; metal-binding site 288681000540 Domain of unknown function DUF59; Region: DUF59; cl00941 288681000541 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 288681000542 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 288681000543 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 288681000544 NodB motif; other site 288681000545 putative active site [active] 288681000546 putative catalytic site [active] 288681000547 Glycerate kinase family; Region: Gly_kinase; cl00841 288681000548 Arginase family; Region: Arginase; cl00306 288681000549 Uncharacterized conserved protein [Function unknown]; Region: COG1624 288681000550 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681000551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 288681000552 YbbR-like protein; Region: YbbR; pfam07949 288681000553 YbbR-like protein; Region: YbbR; pfam07949 288681000554 YbbR-like protein; Region: YbbR; pfam07949 288681000555 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 288681000556 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 288681000557 active site 288681000558 substrate binding site [chemical binding]; other site 288681000559 metal binding site [ion binding]; metal-binding site 288681000560 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 288681000561 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 288681000562 glutaminase active site [active] 288681000563 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288681000564 dimer interface [polypeptide binding]; other site 288681000565 active site 288681000566 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 288681000567 dimer interface [polypeptide binding]; other site 288681000568 active site 288681000569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681000570 Transcriptional regulators [Transcription]; Region: GntR; COG1802 288681000571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681000572 DNA-binding site [nucleotide binding]; DNA binding site 288681000573 FCD domain; Region: FCD; cl11656 288681000574 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 288681000575 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 288681000576 N- and C-terminal domain interface [polypeptide binding]; other site 288681000577 putative active site [active] 288681000578 catalytic site [active] 288681000579 metal binding site [ion binding]; metal-binding site 288681000580 carbohydrate binding site [chemical binding]; other site 288681000581 ATP binding site [chemical binding]; other site 288681000582 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 288681000583 gluconate transporter; Region: gntP; TIGR00791 288681000584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000585 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 288681000586 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 288681000587 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 288681000588 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 288681000589 structural tetrad; other site 288681000590 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681000591 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 288681000592 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681000593 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681000594 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 288681000595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681000596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681000597 DNA binding residues [nucleotide binding] 288681000598 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 288681000599 classical (c) SDRs; Region: SDR_c; cd05233 288681000600 NAD(P) binding site [chemical binding]; other site 288681000601 active site 288681000602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000603 ABC-ATPase subunit interface; other site 288681000604 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288681000605 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 288681000606 Walker A/P-loop; other site 288681000607 ATP binding site [chemical binding]; other site 288681000608 Q-loop/lid; other site 288681000609 ABC transporter signature motif; other site 288681000610 Walker B; other site 288681000611 D-loop; other site 288681000612 H-loop/switch region; other site 288681000613 NIL domain; Region: NIL; cl09633 288681000614 NMT1-like family; Region: NMT1_2; cl15260 288681000615 alcohol dehydrogenase; Provisional; Region: PTZ00354 288681000616 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 288681000617 putative NAD(P) binding site [chemical binding]; other site 288681000618 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 288681000619 FAD binding domain; Region: FAD_binding_4; pfam01565 288681000620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000621 putative substrate translocation pore; other site 288681000622 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 288681000623 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 288681000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000625 putative substrate translocation pore; other site 288681000626 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 288681000627 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 288681000628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681000629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000630 dimer interface [polypeptide binding]; other site 288681000631 conserved gate region; other site 288681000632 putative PBP binding loops; other site 288681000633 ABC-ATPase subunit interface; other site 288681000634 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681000635 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000637 putative PBP binding loops; other site 288681000638 dimer interface [polypeptide binding]; other site 288681000639 ABC-ATPase subunit interface; other site 288681000640 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681000641 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681000642 Walker A/P-loop; other site 288681000643 ATP binding site [chemical binding]; other site 288681000644 Q-loop/lid; other site 288681000645 ABC transporter signature motif; other site 288681000646 Walker B; other site 288681000647 D-loop; other site 288681000648 H-loop/switch region; other site 288681000649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681000650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288681000651 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681000652 Walker A/P-loop; other site 288681000653 ATP binding site [chemical binding]; other site 288681000654 Q-loop/lid; other site 288681000655 ABC transporter signature motif; other site 288681000656 Walker B; other site 288681000657 D-loop; other site 288681000658 H-loop/switch region; other site 288681000659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681000660 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000661 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000662 peptide binding site [polypeptide binding]; other site 288681000663 YusW-like protein; Region: YusW; pfam14039 288681000664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681000665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681000666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681000667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681000668 Helix-turn-helix domains; Region: HTH; cl00088 288681000669 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681000670 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681000671 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681000672 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000674 peptide binding site [polypeptide binding]; other site 288681000675 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000676 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000677 peptide binding site [polypeptide binding]; other site 288681000678 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681000679 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681000680 active site 288681000681 catalytic tetrad [active] 288681000682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000683 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 288681000684 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 288681000685 Sugar transport protein; Region: Sugar_transport; pfam06800 288681000686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000687 dimer interface [polypeptide binding]; other site 288681000688 conserved gate region; other site 288681000689 putative PBP binding loops; other site 288681000690 ABC-ATPase subunit interface; other site 288681000691 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 288681000692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681000693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681000694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681000695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681000696 Helix-turn-helix domains; Region: HTH; cl00088 288681000697 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 288681000698 putative dimerization interface [polypeptide binding]; other site 288681000699 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681000700 EamA-like transporter family; Region: EamA; cl01037 288681000701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288681000702 putative acyl-acceptor binding pocket; other site 288681000703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681000704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681000705 DNA binding site [nucleotide binding] 288681000706 domain linker motif; other site 288681000707 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681000708 putative ligand binding site [chemical binding]; other site 288681000709 putative dimerization interface [polypeptide binding]; other site 288681000710 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681000711 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681000712 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681000713 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681000714 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681000715 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 288681000716 active site 288681000717 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 288681000718 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 288681000719 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 288681000720 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288681000721 catalytic residue [active] 288681000722 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 288681000723 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681000724 nucleotide binding site/active site [active] 288681000725 HIT family signature motif; other site 288681000726 catalytic residue [active] 288681000727 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681000728 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000729 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000730 ABC transporter; Region: ABC_tran_2; pfam12848 288681000731 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000732 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288681000733 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288681000734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681000735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000736 dimer interface [polypeptide binding]; other site 288681000737 conserved gate region; other site 288681000738 putative PBP binding loops; other site 288681000739 ABC-ATPase subunit interface; other site 288681000740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681000741 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681000742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000743 dimer interface [polypeptide binding]; other site 288681000744 conserved gate region; other site 288681000745 putative PBP binding loops; other site 288681000746 ABC-ATPase subunit interface; other site 288681000747 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681000748 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681000749 Walker A/P-loop; other site 288681000750 ATP binding site [chemical binding]; other site 288681000751 Q-loop/lid; other site 288681000752 ABC transporter signature motif; other site 288681000753 Walker B; other site 288681000754 D-loop; other site 288681000755 H-loop/switch region; other site 288681000756 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681000757 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 288681000758 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681000759 Walker A/P-loop; other site 288681000760 ATP binding site [chemical binding]; other site 288681000761 Q-loop/lid; other site 288681000762 ABC transporter signature motif; other site 288681000763 Walker B; other site 288681000764 D-loop; other site 288681000765 H-loop/switch region; other site 288681000766 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681000767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681000768 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681000769 active site 288681000770 motif I; other site 288681000771 motif II; other site 288681000772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681000773 motif II; other site 288681000774 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 288681000775 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 288681000776 dimer interface [polypeptide binding]; other site 288681000777 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 288681000778 active site 288681000779 Fe binding site [ion binding]; other site 288681000780 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 288681000781 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 288681000782 Cupin domain; Region: Cupin_2; cl09118 288681000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681000785 putative substrate translocation pore; other site 288681000786 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 288681000787 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 288681000788 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681000789 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 288681000790 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681000791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681000792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681000793 helicase 45; Provisional; Region: PTZ00424 288681000794 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681000795 ATP binding site [chemical binding]; other site 288681000796 Mg++ binding site [ion binding]; other site 288681000797 motif III; other site 288681000798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681000799 nucleotide binding region [chemical binding]; other site 288681000800 ATP-binding site [chemical binding]; other site 288681000801 UV-endonuclease UvdE; Region: UvdE; cl10036 288681000802 Rhomboid family; Region: Rhomboid; cl11446 288681000803 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 288681000804 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 288681000805 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 288681000806 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288681000807 alanine racemase; Reviewed; Region: alr; PRK00053 288681000808 active site 288681000809 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681000810 dimer interface [polypeptide binding]; other site 288681000811 substrate binding site [chemical binding]; other site 288681000812 catalytic residues [active] 288681000813 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 288681000814 PemK-like protein; Region: PemK; cl00995 288681000815 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 288681000816 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 288681000817 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 288681000818 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 288681000819 RNA binding site [nucleotide binding]; other site 288681000820 hypothetical protein; Provisional; Region: PRK04351 288681000821 SprT homologues; Region: SprT; cl01182 288681000822 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 288681000823 Glycoprotease family; Region: Peptidase_M22; pfam00814 288681000824 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 288681000825 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 288681000826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681000827 Coenzyme A binding pocket [chemical binding]; other site 288681000828 UGMP family protein; Validated; Region: PRK09604 288681000829 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 288681000830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681000831 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000832 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000833 ABC transporter; Region: ABC_tran_2; pfam12848 288681000834 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681000835 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 288681000836 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 288681000837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000838 CAAX protease self-immunity; Region: Abi; cl00558 288681000839 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 288681000840 oligomerisation interface [polypeptide binding]; other site 288681000841 mobile loop; other site 288681000842 roof hairpin; other site 288681000843 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 288681000844 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 288681000845 ring oligomerisation interface [polypeptide binding]; other site 288681000846 ATP/Mg binding site [chemical binding]; other site 288681000847 stacking interactions; other site 288681000848 hinge regions; other site 288681000849 Uncharacterized conserved protein [Function unknown]; Region: COG5444 288681000850 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681000851 GMP synthase; Reviewed; Region: guaA; PRK00074 288681000852 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 288681000853 AMP/PPi binding site [chemical binding]; other site 288681000854 candidate oxyanion hole; other site 288681000855 catalytic triad [active] 288681000856 potential glutamine specificity residues [chemical binding]; other site 288681000857 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 288681000858 ATP Binding subdomain [chemical binding]; other site 288681000859 Ligand Binding sites [chemical binding]; other site 288681000860 Dimerization subdomain; other site 288681000861 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681000862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681000863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681000864 active site 288681000865 phosphorylation site [posttranslational modification] 288681000866 intermolecular recognition site; other site 288681000867 dimerization interface [polypeptide binding]; other site 288681000868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681000869 DNA binding site [nucleotide binding] 288681000870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681000871 dimerization interface [polypeptide binding]; other site 288681000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681000873 dimer interface [polypeptide binding]; other site 288681000874 phosphorylation site [posttranslational modification] 288681000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000876 ATP binding site [chemical binding]; other site 288681000877 Mg2+ binding site [ion binding]; other site 288681000878 G-X-G motif; other site 288681000879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681000880 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681000881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681000882 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 288681000883 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 288681000884 catalytic residues [active] 288681000885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000886 NAD(P) binding site [chemical binding]; other site 288681000887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000888 Bacitracin resistance protein BacA; Region: BacA; cl00858 288681000889 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681000890 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681000891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681000892 Walker A/P-loop; other site 288681000893 ATP binding site [chemical binding]; other site 288681000894 Q-loop/lid; other site 288681000895 ABC transporter signature motif; other site 288681000896 Walker B; other site 288681000897 D-loop; other site 288681000898 H-loop/switch region; other site 288681000899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681000900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681000901 dimer interface [polypeptide binding]; other site 288681000902 phosphorylation site [posttranslational modification] 288681000903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000904 ATP binding site [chemical binding]; other site 288681000905 Mg2+ binding site [ion binding]; other site 288681000906 G-X-G motif; other site 288681000907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681000908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681000909 active site 288681000910 phosphorylation site [posttranslational modification] 288681000911 intermolecular recognition site; other site 288681000912 dimerization interface [polypeptide binding]; other site 288681000913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681000914 DNA binding site [nucleotide binding] 288681000915 EamA-like transporter family; Region: EamA; cl01037 288681000916 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681000917 EamA-like transporter family; Region: EamA; cl01037 288681000918 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 288681000919 AIR carboxylase; Region: AIRC; cl00310 288681000920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000921 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 288681000922 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681000923 adenylosuccinate lyase; Provisional; Region: PRK07492 288681000924 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 288681000925 tetramer interface [polypeptide binding]; other site 288681000926 active site 288681000927 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 288681000928 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 288681000929 ATP binding site [chemical binding]; other site 288681000930 active site 288681000931 substrate binding site [chemical binding]; other site 288681000932 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 288681000933 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 288681000934 putative active site [active] 288681000935 catalytic triad [active] 288681000936 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 288681000937 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 288681000938 dimerization interface [polypeptide binding]; other site 288681000939 ATP binding site [chemical binding]; other site 288681000940 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 288681000941 dimerization interface [polypeptide binding]; other site 288681000942 ATP binding site [chemical binding]; other site 288681000943 amidophosphoribosyltransferase; Provisional; Region: PRK06781 288681000944 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 288681000945 active site 288681000946 tetramer interface [polypeptide binding]; other site 288681000947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000948 active site 288681000949 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 288681000950 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 288681000951 dimerization interface [polypeptide binding]; other site 288681000952 putative ATP binding site [chemical binding]; other site 288681000953 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 288681000954 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 288681000955 active site 288681000956 substrate binding site [chemical binding]; other site 288681000957 cosubstrate binding site; other site 288681000958 catalytic site [active] 288681000959 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 288681000960 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 288681000961 purine monophosphate binding site [chemical binding]; other site 288681000962 dimer interface [polypeptide binding]; other site 288681000963 putative catalytic residues [active] 288681000964 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 288681000965 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 288681000966 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 288681000967 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 288681000968 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681000969 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 288681000970 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 288681000971 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 288681000972 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 288681000973 substrate binding site [chemical binding]; other site 288681000974 putative active site [active] 288681000975 dimer interface [polypeptide binding]; other site 288681000976 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 288681000977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681000978 Family description; Region: UvrD_C_2; cl15862 288681000979 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 288681000980 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 288681000981 nucleotide binding pocket [chemical binding]; other site 288681000982 K-X-D-G motif; other site 288681000983 catalytic site [active] 288681000984 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 288681000985 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 288681000986 Dimer interface [polypeptide binding]; other site 288681000987 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 288681000988 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681000989 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681000990 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 288681000991 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 288681000992 Glutamate binding site [chemical binding]; other site 288681000993 homodimer interface [polypeptide binding]; other site 288681000994 NAD binding site [chemical binding]; other site 288681000995 catalytic residues [active] 288681000996 Isochorismatase family; Region: Isochorismatase; pfam00857 288681000997 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681000998 catalytic triad [active] 288681000999 conserved cis-peptide bond; other site 288681001000 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288681001001 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 288681001002 Walker A/P-loop; other site 288681001003 ATP binding site [chemical binding]; other site 288681001004 Q-loop/lid; other site 288681001005 ABC transporter signature motif; other site 288681001006 Walker B; other site 288681001007 D-loop; other site 288681001008 H-loop/switch region; other site 288681001009 NIL domain; Region: NIL; cl09633 288681001010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681001011 NMT1-like family; Region: NMT1_2; cl15260 288681001012 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 288681001013 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 288681001014 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 288681001015 P loop; other site 288681001016 Nucleotide binding site [chemical binding]; other site 288681001017 DTAP/Switch II; other site 288681001018 Switch I; other site 288681001019 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681001020 putative dimer interface [polypeptide binding]; other site 288681001021 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681001022 Helix-turn-helix domains; Region: HTH; cl00088 288681001023 Helix-turn-helix domains; Region: HTH; cl00088 288681001024 yiaA/B two helix domain; Region: YiaAB; cl01759 288681001025 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 288681001026 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 288681001027 Amidase; Region: Amidase; cl11426 288681001028 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 288681001029 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 288681001030 GatB domain; Region: GatB_Yqey; cl11497 288681001031 putative lipid kinase; Reviewed; Region: PRK13337 288681001032 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 288681001033 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 288681001034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681001035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001036 S-adenosylmethionine binding site [chemical binding]; other site 288681001037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681001038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681001039 motif II; other site 288681001040 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 288681001041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681001042 inhibitor-cofactor binding pocket; inhibition site 288681001043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001044 catalytic residue [active] 288681001045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681001046 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001048 Walker A motif; other site 288681001049 ATP binding site [chemical binding]; other site 288681001050 Walker B motif; other site 288681001051 arginine finger; other site 288681001052 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681001053 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 288681001054 tetramerization interface [polypeptide binding]; other site 288681001055 NAD(P) binding site [chemical binding]; other site 288681001056 catalytic residues [active] 288681001057 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288681001058 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 288681001059 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 288681001060 putative active site [active] 288681001061 putative metal binding site [ion binding]; other site 288681001062 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 288681001063 putative active site [active] 288681001064 putative metal binding site [ion binding]; other site 288681001065 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681001066 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681001067 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681001068 TRAM domain; Region: TRAM; cl01282 288681001069 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 288681001070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001071 S-adenosylmethionine binding site [chemical binding]; other site 288681001072 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 288681001073 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 288681001074 FMN binding site [chemical binding]; other site 288681001075 active site 288681001076 catalytic residues [active] 288681001077 substrate binding site [chemical binding]; other site 288681001078 GAF domain; Region: GAF_2; pfam13185 288681001079 GAF domain; Region: GAF; cl15785 288681001080 GAF domain; Region: GAF; cl15785 288681001081 sensory histidine kinase AtoS; Provisional; Region: PRK11360 288681001082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001083 dimer interface [polypeptide binding]; other site 288681001084 phosphorylation site [posttranslational modification] 288681001085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001086 ATP binding site [chemical binding]; other site 288681001087 Mg2+ binding site [ion binding]; other site 288681001088 G-X-G motif; other site 288681001089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 288681001090 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 288681001091 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 288681001092 Protein of unknown function DUF45; Region: DUF45; cl00636 288681001093 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 288681001094 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 288681001095 active site 288681001096 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681001097 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 288681001098 amidohydrolase; Region: amidohydrolases; TIGR01891 288681001099 metal binding site [ion binding]; metal-binding site 288681001100 putative dimer interface [polypeptide binding]; other site 288681001101 phosphoethanolamine N-methyltransferase; Region: PLN02336 288681001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681001103 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 288681001104 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 288681001105 catalytic residue [active] 288681001106 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 288681001107 catalytic residues [active] 288681001108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681001109 peroxiredoxin; Region: AhpC; TIGR03137 288681001110 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 288681001111 dimer interface [polypeptide binding]; other site 288681001112 decamer (pentamer of dimers) interface [polypeptide binding]; other site 288681001113 catalytic triad [active] 288681001114 peroxidatic and resolving cysteines [active] 288681001115 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681001116 Phosphotransferase enzyme family; Region: APH; pfam01636 288681001117 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 288681001118 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 288681001119 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 288681001120 intersubunit interface [polypeptide binding]; other site 288681001121 active site 288681001122 Zn2+ binding site [ion binding]; other site 288681001123 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001124 ABC-ATPase subunit interface; other site 288681001125 dimer interface [polypeptide binding]; other site 288681001126 putative PBP binding regions; other site 288681001127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001128 ABC-ATPase subunit interface; other site 288681001129 dimer interface [polypeptide binding]; other site 288681001130 putative PBP binding regions; other site 288681001131 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681001132 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681001133 putative ligand binding residues [chemical binding]; other site 288681001134 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 288681001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001136 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681001137 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 288681001138 Putative cyclase; Region: Cyclase; cl00814 288681001139 hypothetical protein; Provisional; Region: PRK06851 288681001140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001141 Walker A motif; other site 288681001142 ATP binding site [chemical binding]; other site 288681001143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681001144 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 288681001145 benzoate transport; Region: 2A0115; TIGR00895 288681001146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001147 putative substrate translocation pore; other site 288681001148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001149 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681001150 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 288681001151 [2Fe-2S] cluster binding site [ion binding]; other site 288681001152 Fatty acid desaturase; Region: FA_desaturase; pfam00487 288681001153 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 288681001154 putative di-iron ligands [ion binding]; other site 288681001155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001156 dimer interface [polypeptide binding]; other site 288681001157 conserved gate region; other site 288681001158 putative PBP binding loops; other site 288681001159 ABC-ATPase subunit interface; other site 288681001160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681001161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001162 substrate binding pocket [chemical binding]; other site 288681001163 membrane-bound complex binding site; other site 288681001164 hinge residues; other site 288681001165 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001166 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 288681001167 Walker A/P-loop; other site 288681001168 ATP binding site [chemical binding]; other site 288681001169 Q-loop/lid; other site 288681001170 ABC transporter signature motif; other site 288681001171 Walker B; other site 288681001172 D-loop; other site 288681001173 H-loop/switch region; other site 288681001174 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681001175 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 288681001176 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001177 dimerization interface [polypeptide binding]; other site 288681001178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001180 dimer interface [polypeptide binding]; other site 288681001181 putative CheW interface [polypeptide binding]; other site 288681001182 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681001183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681001184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001185 dimer interface [polypeptide binding]; other site 288681001186 putative CheW interface [polypeptide binding]; other site 288681001187 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681001188 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681001189 Ca binding site [ion binding]; other site 288681001190 active site 288681001191 catalytic site [active] 288681001192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681001193 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 288681001194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001195 active site turn [active] 288681001196 phosphorylation site [posttranslational modification] 288681001197 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 288681001198 putative catalytic site [active] 288681001199 putative metal binding site [ion binding]; other site 288681001200 putative phosphate binding site [ion binding]; other site 288681001201 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681001202 Predicted membrane protein [Function unknown]; Region: COG1511 288681001203 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681001204 DNA topoisomerase III; Provisional; Region: PRK07726 288681001205 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 288681001206 active site 288681001207 putative interdomain interaction site [polypeptide binding]; other site 288681001208 putative metal-binding site [ion binding]; other site 288681001209 putative nucleotide binding site [chemical binding]; other site 288681001210 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681001211 domain I; other site 288681001212 DNA binding groove [nucleotide binding] 288681001213 phosphate binding site [ion binding]; other site 288681001214 domain II; other site 288681001215 domain III; other site 288681001216 nucleotide binding site [chemical binding]; other site 288681001217 catalytic site [active] 288681001218 domain IV; other site 288681001219 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 288681001220 substrate binding site [chemical binding]; other site 288681001221 multimerization interface [polypeptide binding]; other site 288681001222 ATP binding site [chemical binding]; other site 288681001223 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 288681001224 thiamine phosphate binding site [chemical binding]; other site 288681001225 active site 288681001226 pyrophosphate binding site [ion binding]; other site 288681001227 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681001228 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 288681001229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681001230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001231 dimer interface [polypeptide binding]; other site 288681001232 putative CheW interface [polypeptide binding]; other site 288681001233 Domain of unknown function DUF77; Region: DUF77; cl00307 288681001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001235 dimer interface [polypeptide binding]; other site 288681001236 conserved gate region; other site 288681001237 putative PBP binding loops; other site 288681001238 ABC-ATPase subunit interface; other site 288681001239 NMT1-like family; Region: NMT1_2; cl15260 288681001240 NMT1/THI5 like; Region: NMT1; pfam09084 288681001241 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681001242 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 288681001243 Walker A/P-loop; other site 288681001244 ATP binding site [chemical binding]; other site 288681001245 Q-loop/lid; other site 288681001246 ABC transporter signature motif; other site 288681001247 Walker B; other site 288681001248 D-loop; other site 288681001249 H-loop/switch region; other site 288681001250 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681001251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681001252 Walker A/P-loop; other site 288681001253 ATP binding site [chemical binding]; other site 288681001254 Q-loop/lid; other site 288681001255 ABC transporter signature motif; other site 288681001256 Walker B; other site 288681001257 D-loop; other site 288681001258 H-loop/switch region; other site 288681001259 ABC transporter; Region: ABC_tran_2; pfam12848 288681001260 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681001261 Glyco_18 domain; Region: Glyco_18; smart00636 288681001262 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 288681001263 active site 288681001264 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681001265 Interdomain contacts; other site 288681001266 Cytokine receptor motif; other site 288681001267 Cellulose binding domain; Region: CBM_2; cl02709 288681001268 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 288681001269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681001270 catalytic residues [active] 288681001271 Helix-turn-helix domains; Region: HTH; cl00088 288681001272 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 288681001273 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681001274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001275 putative substrate translocation pore; other site 288681001276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001277 non-specific DNA binding site [nucleotide binding]; other site 288681001278 salt bridge; other site 288681001279 sequence-specific DNA binding site [nucleotide binding]; other site 288681001280 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 288681001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001282 putative substrate translocation pore; other site 288681001283 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 288681001284 Sulfatase; Region: Sulfatase; cl10460 288681001285 YesK-like protein; Region: YesK; pfam14150 288681001286 prolyl-tRNA synthetase; Provisional; Region: PRK08661 288681001287 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 288681001288 dimer interface [polypeptide binding]; other site 288681001289 motif 1; other site 288681001290 active site 288681001291 motif 2; other site 288681001292 motif 3; other site 288681001293 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 288681001294 anticodon binding site; other site 288681001295 zinc-binding site [ion binding]; other site 288681001296 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681001297 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681001298 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001299 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001300 putative metal binding site [ion binding]; other site 288681001301 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001302 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001303 putative metal binding site [ion binding]; other site 288681001304 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001305 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001306 putative metal binding site [ion binding]; other site 288681001307 Integral membrane protein TerC family; Region: TerC; cl10468 288681001308 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 288681001309 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 288681001310 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 288681001311 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 288681001312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001313 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 288681001314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681001315 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 288681001316 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 288681001317 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681001318 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 288681001319 active site 288681001320 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 288681001321 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 288681001322 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 288681001323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001324 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681001325 EamA-like transporter family; Region: EamA; cl01037 288681001326 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681001327 EamA-like transporter family; Region: EamA; cl01037 288681001328 YhhN-like protein; Region: YhhN; cl01505 288681001329 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681001330 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681001331 Catalytic site [active] 288681001332 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681001333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681001334 binding surface 288681001335 TPR motif; other site 288681001336 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681001337 EamA-like transporter family; Region: EamA; cl01037 288681001338 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 288681001339 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 288681001340 calcium/proton exchanger (cax); Region: cax; TIGR00378 288681001341 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 288681001342 YfkD-like protein; Region: YfkD; pfam14167 288681001343 Radical SAM superfamily; Region: Radical_SAM; pfam04055 288681001344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681001345 FeS/SAM binding site; other site 288681001346 YfkB-like domain; Region: YfkB; pfam08756 288681001347 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 288681001348 Fumarase C-terminus; Region: Fumerase_C; cl00795 288681001349 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 288681001350 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681001351 NodB motif; other site 288681001352 active site 288681001353 catalytic site [active] 288681001354 Cd binding site [ion binding]; other site 288681001355 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681001356 endonuclease III; Region: ENDO3c; smart00478 288681001357 minor groove reading motif; other site 288681001358 helix-hairpin-helix signature motif; other site 288681001359 substrate binding pocket [chemical binding]; other site 288681001360 active site 288681001361 TRAM domain; Region: TRAM; cl01282 288681001362 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 288681001363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001364 S-adenosylmethionine binding site [chemical binding]; other site 288681001365 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 288681001366 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 288681001367 dimerization interface 3.5A [polypeptide binding]; other site 288681001368 active site 288681001369 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001371 Walker A motif; other site 288681001372 ATP binding site [chemical binding]; other site 288681001373 Walker B motif; other site 288681001374 arginine finger; other site 288681001375 Helix-turn-helix domains; Region: HTH; cl00088 288681001376 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 288681001377 S-methylmethionine transporter; Provisional; Region: PRK11387 288681001378 acetylornithine deacetylase; Validated; Region: PRK08596 288681001379 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288681001380 metal binding site [ion binding]; metal-binding site 288681001381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001382 non-specific DNA binding site [nucleotide binding]; other site 288681001383 salt bridge; other site 288681001384 sequence-specific DNA binding site [nucleotide binding]; other site 288681001385 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 288681001386 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 288681001387 Domain of unknown function DUF; Region: DUF204; pfam02659 288681001388 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 288681001389 Glutaminase; Region: Glutaminase; cl00907 288681001390 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 288681001391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681001392 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001393 active site turn [active] 288681001394 phosphorylation site [posttranslational modification] 288681001395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681001396 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681001397 Ligand binding site; other site 288681001398 Putative Catalytic site; other site 288681001399 DXD motif; other site 288681001400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681001401 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 288681001402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001403 NAD(P) binding site [chemical binding]; other site 288681001404 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681001405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001407 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681001408 NAD(P) binding site [chemical binding]; other site 288681001409 active site 288681001410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681001411 active site 288681001412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681001413 active site 288681001414 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 288681001415 Pyruvate formate lyase 1; Region: PFL1; cd01678 288681001416 coenzyme A binding site [chemical binding]; other site 288681001417 active site 288681001418 catalytic residues [active] 288681001419 glycine loop; other site 288681001420 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 288681001421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681001422 FeS/SAM binding site; other site 288681001423 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 288681001424 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681001425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681001426 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 288681001427 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 288681001428 active site 288681001429 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 288681001430 TIGR01777 family protein; Region: yfcH 288681001431 putative NAD(P) binding site [chemical binding]; other site 288681001432 putative active site [active] 288681001433 RecX family; Region: RecX; cl00936 288681001434 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 288681001435 WVELL protein; Region: WVELL; pfam14043 288681001436 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 288681001437 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 288681001438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681001439 minor groove reading motif; other site 288681001440 helix-hairpin-helix signature motif; other site 288681001441 substrate binding pocket [chemical binding]; other site 288681001442 active site 288681001443 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 288681001444 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 288681001445 DNA binding and oxoG recognition site [nucleotide binding] 288681001446 YgaB-like protein; Region: YgaB; pfam14182 288681001447 Protein of unknown function (DUF402); Region: DUF402; cl00979 288681001448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681001449 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681001450 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 288681001451 Walker A/P-loop; other site 288681001452 ATP binding site [chemical binding]; other site 288681001453 Q-loop/lid; other site 288681001454 ABC transporter signature motif; other site 288681001455 Walker B; other site 288681001456 D-loop; other site 288681001457 H-loop/switch region; other site 288681001458 Predicted membrane protein [Function unknown]; Region: COG4129 288681001459 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 288681001460 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 288681001461 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 288681001462 active site 288681001463 dimer interface [polypeptide binding]; other site 288681001464 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 288681001465 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 288681001466 active site 288681001467 FMN binding site [chemical binding]; other site 288681001468 substrate binding site [chemical binding]; other site 288681001469 3Fe-4S cluster binding site [ion binding]; other site 288681001470 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 288681001471 domain_subunit interface; other site 288681001472 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 288681001473 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681001474 inhibitor-cofactor binding pocket; inhibition site 288681001475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001476 catalytic residue [active] 288681001477 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 288681001478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681001479 Walker A/P-loop; other site 288681001480 ATP binding site [chemical binding]; other site 288681001481 Q-loop/lid; other site 288681001482 ABC transporter signature motif; other site 288681001483 Walker B; other site 288681001484 D-loop; other site 288681001485 H-loop/switch region; other site 288681001486 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 288681001487 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 288681001488 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 288681001489 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 288681001490 Ion channel; Region: Ion_trans_2; cl11596 288681001491 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 288681001492 catalytic triad [active] 288681001493 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681001494 metal binding site 2 [ion binding]; metal-binding site 288681001495 putative DNA binding helix; other site 288681001496 metal binding site 1 [ion binding]; metal-binding site 288681001497 dimer interface [polypeptide binding]; other site 288681001498 structural Zn2+ binding site [ion binding]; other site 288681001499 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 288681001500 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 288681001501 Transcriptional regulator; Region: Transcrip_reg; cl00361 288681001502 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681001503 nudix motif; other site 288681001504 Transglycosylase; Region: Transgly; cl07896 288681001505 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288681001506 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 288681001507 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 288681001508 NlpC/P60 family; Region: NLPC_P60; cl11438 288681001509 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 288681001510 PAS fold; Region: PAS_4; pfam08448 288681001511 PAS domain S-box; Region: sensory_box; TIGR00229 288681001512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681001513 putative active site [active] 288681001514 heme pocket [chemical binding]; other site 288681001515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681001516 metal binding site [ion binding]; metal-binding site 288681001517 active site 288681001518 I-site; other site 288681001519 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681001520 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 288681001521 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 288681001522 Uncharacterized conserved protein [Function unknown]; Region: COG2718 288681001523 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681001524 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681001525 heme-binding site [chemical binding]; other site 288681001526 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001527 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001528 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 288681001529 Substrate binding site [chemical binding]; other site 288681001530 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001531 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001532 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001533 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001534 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 288681001535 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681001536 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 288681001537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001538 substrate binding pocket [chemical binding]; other site 288681001539 membrane-bound complex binding site; other site 288681001540 hinge residues; other site 288681001541 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001542 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 288681001543 Walker A/P-loop; other site 288681001544 ATP binding site [chemical binding]; other site 288681001545 Q-loop/lid; other site 288681001546 ABC transporter signature motif; other site 288681001547 Walker B; other site 288681001548 D-loop; other site 288681001549 H-loop/switch region; other site 288681001550 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288681001551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001552 dimer interface [polypeptide binding]; other site 288681001553 conserved gate region; other site 288681001554 putative PBP binding loops; other site 288681001555 ABC-ATPase subunit interface; other site 288681001556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001557 dimer interface [polypeptide binding]; other site 288681001558 conserved gate region; other site 288681001559 putative PBP binding loops; other site 288681001560 ABC-ATPase subunit interface; other site 288681001561 BCCT family transporter; Region: BCCT; cl00569 288681001562 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681001563 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681001564 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681001565 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681001566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 288681001567 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 288681001568 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681001569 Cache domain; Region: Cache_1; pfam02743 288681001570 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 288681001571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001572 dimerization interface [polypeptide binding]; other site 288681001573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681001574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001575 dimer interface [polypeptide binding]; other site 288681001576 putative CheW interface [polypeptide binding]; other site 288681001577 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 288681001578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681001579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001580 ATP binding site [chemical binding]; other site 288681001581 Mg2+ binding site [ion binding]; other site 288681001582 G-X-G motif; other site 288681001583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001584 active site 288681001585 phosphorylation site [posttranslational modification] 288681001586 intermolecular recognition site; other site 288681001587 dimerization interface [polypeptide binding]; other site 288681001588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681001589 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681001590 Probable transposase; Region: OrfB_IS605; pfam01385 288681001591 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 288681001592 Citrate transporter; Region: CitMHS; pfam03600 288681001593 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 288681001594 NosL; Region: NosL; cl01769 288681001595 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001596 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 288681001597 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001598 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681001599 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001600 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 288681001601 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681001602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681001603 Walker A/P-loop; other site 288681001604 ATP binding site [chemical binding]; other site 288681001605 Q-loop/lid; other site 288681001606 ABC transporter signature motif; other site 288681001607 Walker B; other site 288681001608 D-loop; other site 288681001609 H-loop/switch region; other site 288681001610 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 288681001611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001612 dimer interface [polypeptide binding]; other site 288681001613 conserved gate region; other site 288681001614 putative PBP binding loops; other site 288681001615 ABC-ATPase subunit interface; other site 288681001616 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288681001617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681001618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001619 dimer interface [polypeptide binding]; other site 288681001620 conserved gate region; other site 288681001621 putative PBP binding loops; other site 288681001622 ABC-ATPase subunit interface; other site 288681001623 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288681001624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681001625 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681001626 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 288681001627 active site 288681001628 metal binding site [ion binding]; metal-binding site 288681001629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001631 active site 288681001632 phosphorylation site [posttranslational modification] 288681001633 intermolecular recognition site; other site 288681001634 dimerization interface [polypeptide binding]; other site 288681001635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681001636 DNA binding site [nucleotide binding] 288681001637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001638 dimer interface [polypeptide binding]; other site 288681001639 phosphorylation site [posttranslational modification] 288681001640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001641 ATP binding site [chemical binding]; other site 288681001642 Mg2+ binding site [ion binding]; other site 288681001643 G-X-G motif; other site 288681001644 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681001645 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 288681001646 putative active site [active] 288681001647 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681001648 Cache domain; Region: Cache_1; pfam02743 288681001649 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 288681001650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001651 dimerization interface [polypeptide binding]; other site 288681001652 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681001653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001654 dimer interface [polypeptide binding]; other site 288681001655 putative CheW interface [polypeptide binding]; other site 288681001656 sensory histidine kinase DcuS; Provisional; Region: PRK11086 288681001657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001658 ATP binding site [chemical binding]; other site 288681001659 Mg2+ binding site [ion binding]; other site 288681001660 G-X-G motif; other site 288681001661 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 288681001662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001663 active site 288681001664 phosphorylation site [posttranslational modification] 288681001665 intermolecular recognition site; other site 288681001666 dimerization interface [polypeptide binding]; other site 288681001667 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 288681001668 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 288681001669 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681001670 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 288681001671 putative NAD(P) binding site [chemical binding]; other site 288681001672 Predicted permeases [General function prediction only]; Region: RarD; COG2962 288681001673 EamA-like transporter family; Region: EamA; cl01037 288681001674 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681001675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681001676 DNA-binding site [nucleotide binding]; DNA binding site 288681001677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001679 homodimer interface [polypeptide binding]; other site 288681001680 catalytic residue [active] 288681001681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681001683 Coenzyme A binding pocket [chemical binding]; other site 288681001684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681001685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001686 dimer interface [polypeptide binding]; other site 288681001687 phosphorylation site [posttranslational modification] 288681001688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001689 ATP binding site [chemical binding]; other site 288681001690 Mg2+ binding site [ion binding]; other site 288681001691 G-X-G motif; other site 288681001692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681001693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001694 active site 288681001695 phosphorylation site [posttranslational modification] 288681001696 intermolecular recognition site; other site 288681001697 dimerization interface [polypeptide binding]; other site 288681001698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681001699 DNA binding site [nucleotide binding] 288681001700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681001701 Arrestin_N terminal like; Region: LDB19; pfam13002 288681001702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681001703 Coenzyme A binding pocket [chemical binding]; other site 288681001704 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 288681001705 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 288681001706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 288681001707 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 288681001708 4Fe-4S binding domain; Region: Fer4; cl02805 288681001709 4Fe-4S binding domain; Region: Fer4; cl02805 288681001710 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 288681001711 [4Fe-4S] binding site [ion binding]; other site 288681001712 molybdopterin cofactor binding site; other site 288681001713 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 288681001714 molybdopterin cofactor binding site; other site 288681001715 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 288681001716 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 288681001717 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681001718 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 288681001719 putative active site [active] 288681001720 catalytic site [active] 288681001721 putative metal binding site [ion binding]; other site 288681001722 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288681001723 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 288681001724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001725 amino acid transporter; Region: 2A0306; TIGR00909 288681001726 Spore germination protein; Region: Spore_permease; cl15802 288681001727 Spore germination protein; Region: Spore_permease; cl15802 288681001728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681001729 dimerization interface [polypeptide binding]; other site 288681001730 putative DNA binding site [nucleotide binding]; other site 288681001731 putative Zn2+ binding site [ion binding]; other site 288681001732 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681001733 metal-binding site [ion binding] 288681001734 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288681001735 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 288681001736 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001737 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681001738 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 288681001739 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 288681001740 active site 288681001741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001742 non-specific DNA binding site [nucleotide binding]; other site 288681001743 salt bridge; other site 288681001744 sequence-specific DNA binding site [nucleotide binding]; other site 288681001745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681001746 binding surface 288681001747 TPR motif; other site 288681001748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681001749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681001750 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681001751 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681001752 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 288681001753 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681001754 active site 288681001755 Zn binding site [ion binding]; other site 288681001756 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681001757 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 288681001758 VanW like protein; Region: VanW; pfam04294 288681001759 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681001760 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681001761 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681001762 Nucleoside recognition; Region: Gate; cl00486 288681001763 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681001764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 288681001765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681001766 putative metal binding site [ion binding]; other site 288681001767 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681001768 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681001769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681001770 Transporter associated domain; Region: CorC_HlyC; cl08393 288681001771 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 288681001772 Aspartase; Region: Aspartase; cd01357 288681001773 active sites [active] 288681001774 tetramer interface [polypeptide binding]; other site 288681001775 glycolate transporter; Provisional; Region: PRK09695 288681001776 L-lactate permease; Region: Lactate_perm; cl00701 288681001777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681001778 putative DNA binding site [nucleotide binding]; other site 288681001779 putative Zn2+ binding site [ion binding]; other site 288681001780 Small acid-soluble spore protein H family; Region: SspH; cl06949 288681001781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681001782 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681001783 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 288681001784 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 288681001785 siderophore binding site; other site 288681001786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001787 ABC-ATPase subunit interface; other site 288681001788 dimer interface [polypeptide binding]; other site 288681001789 putative PBP binding regions; other site 288681001790 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681001791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001792 ABC-ATPase subunit interface; other site 288681001793 dimer interface [polypeptide binding]; other site 288681001794 putative PBP binding regions; other site 288681001795 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681001796 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681001797 Walker A/P-loop; other site 288681001798 ATP binding site [chemical binding]; other site 288681001799 Q-loop/lid; other site 288681001800 ABC transporter signature motif; other site 288681001801 Walker B; other site 288681001802 D-loop; other site 288681001803 H-loop/switch region; other site 288681001804 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681001805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001806 S-adenosylmethionine binding site [chemical binding]; other site 288681001807 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 288681001808 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 288681001809 substrate-cofactor binding pocket; other site 288681001810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001811 catalytic residue [active] 288681001812 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681001813 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 288681001814 NAD binding site [chemical binding]; other site 288681001815 homodimer interface [polypeptide binding]; other site 288681001816 active site 288681001817 putative substrate binding site [chemical binding]; other site 288681001818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681001819 active site 288681001820 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681001821 nudix motif; other site 288681001822 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 288681001823 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 288681001824 metal ion-dependent adhesion site (MIDAS); other site 288681001825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001826 Walker A motif; other site 288681001827 ATP binding site [chemical binding]; other site 288681001828 Walker B motif; other site 288681001829 arginine finger; other site 288681001830 cardiolipin synthetase; Reviewed; Region: PRK12452 288681001831 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288681001832 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681001833 putative active site [active] 288681001834 catalytic site [active] 288681001835 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681001836 putative active site [active] 288681001837 catalytic site [active] 288681001838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681001839 PAS domain; Region: PAS_9; pfam13426 288681001840 putative active site [active] 288681001841 heme pocket [chemical binding]; other site 288681001842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681001843 metal binding site [ion binding]; metal-binding site 288681001844 active site 288681001845 I-site; other site 288681001846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681001847 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 288681001848 Spore germination protein; Region: Spore_permease; cl15802 288681001849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681001850 DNA-binding site [nucleotide binding]; DNA binding site 288681001851 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 288681001852 UTRA domain; Region: UTRA; cl01230 288681001853 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 288681001854 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001855 active site turn [active] 288681001856 phosphorylation site [posttranslational modification] 288681001857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681001858 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681001859 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681001860 Ca binding site [ion binding]; other site 288681001861 active site 288681001862 catalytic site [active] 288681001863 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681001864 Spore germination protein; Region: Spore_permease; cl15802 288681001865 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681001866 CAAX protease self-immunity; Region: Abi; cl00558 288681001867 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681001868 active site 288681001869 ATP binding site [chemical binding]; other site 288681001870 substrate binding site [chemical binding]; other site 288681001871 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681001872 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681001873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001874 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 288681001875 Walker A/P-loop; other site 288681001876 ATP binding site [chemical binding]; other site 288681001877 Q-loop/lid; other site 288681001878 ABC transporter signature motif; other site 288681001879 Walker B; other site 288681001880 D-loop; other site 288681001881 H-loop/switch region; other site 288681001882 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681001883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001884 substrate binding pocket [chemical binding]; other site 288681001885 membrane-bound complex binding site; other site 288681001886 hinge residues; other site 288681001887 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288681001888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001889 dimer interface [polypeptide binding]; other site 288681001890 conserved gate region; other site 288681001891 putative PBP binding loops; other site 288681001892 ABC-ATPase subunit interface; other site 288681001893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001894 dimer interface [polypeptide binding]; other site 288681001895 conserved gate region; other site 288681001896 putative PBP binding loops; other site 288681001897 ABC-ATPase subunit interface; other site 288681001898 S-methylmethionine transporter; Provisional; Region: PRK11387 288681001899 OsmC-like protein; Region: OsmC; cl00767 288681001900 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681001901 nucleotide binding site/active site [active] 288681001902 HIT family signature motif; other site 288681001903 catalytic residue [active] 288681001904 RNA polymerase sigma factor; Provisional; Region: PRK12542 288681001905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681001906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681001907 DNA binding residues [nucleotide binding] 288681001908 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 288681001909 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681001910 Helix-turn-helix domains; Region: HTH; cl00088 288681001911 WYL domain; Region: WYL; cl14852 288681001912 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 288681001913 folate binding site [chemical binding]; other site 288681001914 NADP+ binding site [chemical binding]; other site 288681001915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001916 dimerization interface [polypeptide binding]; other site 288681001917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001918 dimer interface [polypeptide binding]; other site 288681001919 phosphorylation site [posttranslational modification] 288681001920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001921 ATP binding site [chemical binding]; other site 288681001922 Mg2+ binding site [ion binding]; other site 288681001923 G-X-G motif; other site 288681001924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681001925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001926 active site 288681001927 phosphorylation site [posttranslational modification] 288681001928 intermolecular recognition site; other site 288681001929 dimerization interface [polypeptide binding]; other site 288681001930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681001931 DNA binding site [nucleotide binding] 288681001932 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 288681001933 Sulfate transporter family; Region: Sulfate_transp; cl15842 288681001934 Sulfate transporter family; Region: Sulfate_transp; cl15842 288681001935 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681001936 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288681001937 Ligand Binding Site [chemical binding]; other site 288681001938 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 288681001939 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288681001940 peptide binding site [polypeptide binding]; other site 288681001941 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 288681001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001943 dimer interface [polypeptide binding]; other site 288681001944 conserved gate region; other site 288681001945 putative PBP binding loops; other site 288681001946 ABC-ATPase subunit interface; other site 288681001947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681001948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001949 putative PBP binding loops; other site 288681001950 ABC-ATPase subunit interface; other site 288681001951 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288681001952 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681001953 Walker A/P-loop; other site 288681001954 ATP binding site [chemical binding]; other site 288681001955 Q-loop/lid; other site 288681001956 ABC transporter signature motif; other site 288681001957 Walker B; other site 288681001958 D-loop; other site 288681001959 H-loop/switch region; other site 288681001960 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681001961 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681001962 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681001963 Walker A/P-loop; other site 288681001964 ATP binding site [chemical binding]; other site 288681001965 Q-loop/lid; other site 288681001966 ABC transporter signature motif; other site 288681001967 Walker B; other site 288681001968 D-loop; other site 288681001969 H-loop/switch region; other site 288681001970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681001971 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 288681001972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001973 putative substrate translocation pore; other site 288681001974 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681001975 Helix-turn-helix domains; Region: HTH; cl00088 288681001976 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681001977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001978 putative substrate translocation pore; other site 288681001979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681001980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681001981 DNA binding site [nucleotide binding] 288681001982 domain linker motif; other site 288681001983 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 288681001984 dimerization interface [polypeptide binding]; other site 288681001985 ligand binding site [chemical binding]; other site 288681001986 sodium binding site [ion binding]; other site 288681001987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681001988 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 288681001989 substrate binding site [chemical binding]; other site 288681001990 dimer interface [polypeptide binding]; other site 288681001991 ATP binding site [chemical binding]; other site 288681001992 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 288681001993 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 288681001994 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 288681001995 Walker A/P-loop; other site 288681001996 ATP binding site [chemical binding]; other site 288681001997 Q-loop/lid; other site 288681001998 ABC transporter signature motif; other site 288681001999 Walker B; other site 288681002000 D-loop; other site 288681002001 H-loop/switch region; other site 288681002002 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 288681002003 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681002004 TM-ABC transporter signature motif; other site 288681002005 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 288681002006 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 288681002007 ligand binding site [chemical binding]; other site 288681002008 dimerization interface [polypeptide binding]; other site 288681002009 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 288681002010 active site 288681002011 intersubunit interactions; other site 288681002012 catalytic residue [active] 288681002013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 288681002014 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 288681002015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002017 putative substrate translocation pore; other site 288681002018 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681002019 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681002020 putative NAD(P) binding site [chemical binding]; other site 288681002021 catalytic Zn binding site [ion binding]; other site 288681002022 Ion channel; Region: Ion_trans_2; cl11596 288681002023 Ion channel; Region: Ion_trans_2; cl11596 288681002024 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 288681002025 Zn binding site [ion binding]; other site 288681002026 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 288681002027 putative catalytic site [active] 288681002028 metal binding site A [ion binding]; metal-binding site 288681002029 phosphate binding site [ion binding]; other site 288681002030 metal binding site C [ion binding]; metal-binding site 288681002031 metal binding site B [ion binding]; metal-binding site 288681002032 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 288681002033 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 288681002034 dimer interface [polypeptide binding]; other site 288681002035 active site 288681002036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681002037 substrate binding site [chemical binding]; other site 288681002038 catalytic residue [active] 288681002039 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 288681002040 FAD binding domain; Region: FAD_binding_4; pfam01565 288681002041 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 288681002042 VanZ like family; Region: VanZ; cl01971 288681002043 RDD family; Region: RDD; cl00746 288681002044 Bacitracin resistance protein BacA; Region: BacA; cl00858 288681002045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681002046 dimer interface [polypeptide binding]; other site 288681002047 putative CheW interface [polypeptide binding]; other site 288681002048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681002049 3D domain; Region: 3D; cl01439 288681002050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681002051 non-specific DNA binding site [nucleotide binding]; other site 288681002052 salt bridge; other site 288681002053 sequence-specific DNA binding site [nucleotide binding]; other site 288681002054 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 288681002055 active site 288681002056 catalytic site [active] 288681002057 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681002058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002059 putative substrate translocation pore; other site 288681002060 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681002061 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 288681002062 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 288681002063 Predicted membrane protein [Function unknown]; Region: COG5373 288681002064 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 288681002065 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 288681002066 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681002067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681002068 non-specific DNA binding site [nucleotide binding]; other site 288681002069 salt bridge; other site 288681002070 sequence-specific DNA binding site [nucleotide binding]; other site 288681002071 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681002072 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 288681002073 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681002074 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681002075 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681002076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681002077 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 288681002078 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 288681002079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 288681002080 Subunit I/III interface [polypeptide binding]; other site 288681002081 Subunit III/IV interface [polypeptide binding]; other site 288681002082 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 288681002083 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 288681002084 D-pathway; other site 288681002085 Putative ubiquinol binding site [chemical binding]; other site 288681002086 Low-spin heme (heme b) binding site [chemical binding]; other site 288681002087 Putative water exit pathway; other site 288681002088 Binuclear center (heme o3/CuB) [ion binding]; other site 288681002089 K-pathway; other site 288681002090 Putative proton exit pathway; other site 288681002091 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 288681002092 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 288681002093 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681002094 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 288681002095 putative active site [active] 288681002096 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681002097 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 288681002098 metal binding site [ion binding]; metal-binding site 288681002099 dimer interface [polypeptide binding]; other site 288681002100 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 288681002101 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 288681002102 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681002103 Na binding site [ion binding]; other site 288681002104 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681002105 Spore germination protein; Region: Spore_permease; cl15802 288681002106 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681002107 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 288681002108 Nucleoside recognition; Region: Gate; cl00486 288681002109 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 288681002110 Nucleoside recognition; Region: Gate; cl00486 288681002111 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 288681002112 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 288681002113 G1 box; other site 288681002114 GTP/Mg2+ binding site [chemical binding]; other site 288681002115 Switch I region; other site 288681002116 G2 box; other site 288681002117 G3 box; other site 288681002118 Switch II region; other site 288681002119 G4 box; other site 288681002120 G5 box; other site 288681002121 FeoA domain; Region: FeoA; cl00838 288681002122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681002123 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 288681002124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002125 dimer interface [polypeptide binding]; other site 288681002126 conserved gate region; other site 288681002127 putative PBP binding loops; other site 288681002128 ABC-ATPase subunit interface; other site 288681002129 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 288681002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002131 dimer interface [polypeptide binding]; other site 288681002132 conserved gate region; other site 288681002133 putative PBP binding loops; other site 288681002134 ABC-ATPase subunit interface; other site 288681002135 Predicted kinase [General function prediction only]; Region: COG0645 288681002136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002137 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 288681002138 FOG: CBS domain [General function prediction only]; Region: COG0517 288681002139 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 288681002140 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 288681002141 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 288681002142 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002143 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002144 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002145 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681002146 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 288681002147 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681002148 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 288681002149 Walker A/P-loop; other site 288681002150 ATP binding site [chemical binding]; other site 288681002151 Q-loop/lid; other site 288681002152 ABC transporter signature motif; other site 288681002153 Walker B; other site 288681002154 D-loop; other site 288681002155 H-loop/switch region; other site 288681002156 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002158 dimer interface [polypeptide binding]; other site 288681002159 conserved gate region; other site 288681002160 putative PBP binding loops; other site 288681002161 ABC-ATPase subunit interface; other site 288681002162 NMT1/THI5 like; Region: NMT1; pfam09084 288681002163 NMT1-like family; Region: NMT1_2; cl15260 288681002164 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 288681002165 thiamine phosphate binding site [chemical binding]; other site 288681002166 active site 288681002167 pyrophosphate binding site [ion binding]; other site 288681002168 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 288681002169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681002170 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 288681002171 thiS-thiF/thiG interaction site; other site 288681002172 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 288681002173 ThiS interaction site; other site 288681002174 putative active site [active] 288681002175 tetramer interface [polypeptide binding]; other site 288681002176 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 288681002177 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681002178 ATP binding site [chemical binding]; other site 288681002179 substrate interface [chemical binding]; other site 288681002180 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288681002181 dimer interface [polypeptide binding]; other site 288681002182 substrate binding site [chemical binding]; other site 288681002183 ATP binding site [chemical binding]; other site 288681002184 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 288681002185 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 288681002186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681002187 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681002188 K+-transporting ATPase, c chain; Region: KdpC; cl00944 288681002189 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 288681002190 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 288681002191 Ligand Binding Site [chemical binding]; other site 288681002192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002194 putative substrate translocation pore; other site 288681002195 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681002196 Helix-turn-helix domains; Region: HTH; cl00088 288681002197 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 288681002198 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 288681002199 active site 288681002200 nucleophile elbow; other site 288681002201 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681002202 short chain dehydrogenase; Provisional; Region: PRK06701 288681002203 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 288681002204 NAD binding site [chemical binding]; other site 288681002205 metal binding site [ion binding]; metal-binding site 288681002206 active site 288681002207 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 288681002208 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 288681002209 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681002210 catalytic residues [active] 288681002211 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 288681002212 YhdB-like protein; Region: YhdB; pfam14148 288681002213 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 288681002214 Spore germination protein; Region: Spore_permease; cl15802 288681002215 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681002216 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681002217 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 288681002218 putative FMN binding site [chemical binding]; other site 288681002219 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 288681002220 SpoVR like protein; Region: SpoVR; pfam04293 288681002221 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 288681002222 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 288681002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681002224 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681002225 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 288681002226 active site residue [active] 288681002227 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 288681002228 putative homodimer interface [polypeptide binding]; other site 288681002229 putative homotetramer interface [polypeptide binding]; other site 288681002230 putative metal binding site [ion binding]; other site 288681002231 putative homodimer-homodimer interface [polypeptide binding]; other site 288681002232 putative allosteric switch controlling residues; other site 288681002233 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 288681002234 CPxP motif; other site 288681002235 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002236 active site residue [active] 288681002237 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 288681002238 active site residue [active] 288681002239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681002240 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 288681002241 CPxP motif; other site 288681002242 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002243 active site residue [active] 288681002244 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002245 active site residue [active] 288681002246 DsrE/DsrF-like family; Region: DrsE; cl00672 288681002247 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681002248 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681002249 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 288681002250 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 288681002251 NADP binding site [chemical binding]; other site 288681002252 dimer interface [polypeptide binding]; other site 288681002253 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 288681002254 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 288681002255 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 288681002256 PhoU domain; Region: PhoU; pfam01895 288681002257 PhoU domain; Region: PhoU; pfam01895 288681002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002260 putative substrate translocation pore; other site 288681002261 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 288681002262 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 288681002263 Helix-turn-helix domains; Region: HTH; cl00088 288681002264 Helix-turn-helix domains; Region: HTH; cl00088 288681002265 PRD domain; Region: PRD; cl15445 288681002266 PRD domain; Region: PRD; cl15445 288681002267 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 288681002268 active site 288681002269 P-loop; other site 288681002270 phosphorylation site [posttranslational modification] 288681002271 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681002272 active site 288681002273 phosphorylation site [posttranslational modification] 288681002274 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681002275 active site 288681002276 methionine cluster; other site 288681002277 phosphorylation site [posttranslational modification] 288681002278 metal binding site [ion binding]; metal-binding site 288681002279 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681002280 active site 288681002281 P-loop; other site 288681002282 phosphorylation site [posttranslational modification] 288681002283 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681002284 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681002285 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 288681002286 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002287 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002288 3D domain; Region: 3D; cl01439 288681002289 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681002290 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681002291 FtsX-like permease family; Region: FtsX; cl15850 288681002292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681002293 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681002294 Walker A/P-loop; other site 288681002295 ATP binding site [chemical binding]; other site 288681002296 Q-loop/lid; other site 288681002297 ABC transporter signature motif; other site 288681002298 Walker B; other site 288681002299 D-loop; other site 288681002300 H-loop/switch region; other site 288681002301 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 288681002302 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 288681002303 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 288681002304 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 288681002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681002306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002307 dimer interface [polypeptide binding]; other site 288681002308 conserved gate region; other site 288681002309 ABC-ATPase subunit interface; other site 288681002310 FtsX-like permease family; Region: FtsX; cl15850 288681002311 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681002312 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 288681002313 dimanganese center [ion binding]; other site 288681002314 CotJB protein; Region: CotJB; pfam12652 288681002315 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 288681002316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002317 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681002318 active site 288681002319 metal binding site [ion binding]; metal-binding site 288681002320 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002321 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002322 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 288681002323 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 288681002324 putative DNA binding site [nucleotide binding]; other site 288681002325 putative homodimer interface [polypeptide binding]; other site 288681002326 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 288681002327 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681002328 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681002329 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002330 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002331 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681002333 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681002334 active site 288681002335 metal binding site [ion binding]; metal-binding site 288681002336 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681002337 Interdomain contacts; other site 288681002338 Cytokine receptor motif; other site 288681002339 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 288681002340 Spore germination protein; Region: Spore_permease; cl15802 288681002341 amino acid transporter; Region: 2A0306; TIGR00909 288681002342 Spore germination protein; Region: Spore_permease; cl15802 288681002343 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681002344 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288681002345 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 288681002346 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288681002347 putative active site [active] 288681002348 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 288681002349 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 288681002350 putative active site [active] 288681002351 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681002352 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 288681002353 active site turn [active] 288681002354 phosphorylation site [posttranslational modification] 288681002355 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681002356 Probable transposase; Region: OrfB_IS605; pfam01385 288681002357 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681002358 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 288681002359 DoxX; Region: DoxX; cl00976 288681002360 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288681002361 hypothetical protein; Provisional; Region: PRK06770 288681002362 EamA-like transporter family; Region: EamA; cl01037 288681002363 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681002364 EamA-like transporter family; Region: EamA; cl01037 288681002365 Helix-turn-helix domains; Region: HTH; cl00088 288681002366 AsnC family; Region: AsnC_trans_reg; pfam01037 288681002367 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 288681002368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681002369 Coenzyme A binding pocket [chemical binding]; other site 288681002370 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288681002371 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288681002372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002373 Helix-turn-helix domains; Region: HTH; cl00088 288681002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002377 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681002378 Helix-turn-helix domains; Region: HTH; cl00088 288681002379 hypothetical protein; Provisional; Region: PRK06847 288681002380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681002381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002382 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681002383 putative substrate translocation pore; other site 288681002384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681002385 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288681002386 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681002387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002388 Helix-turn-helix domains; Region: HTH; cl00088 288681002389 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 288681002390 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 288681002391 Helix-turn-helix domains; Region: HTH; cl00088 288681002392 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681002393 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681002394 putative NAD(P) binding site [chemical binding]; other site 288681002395 catalytic Zn binding site [ion binding]; other site 288681002396 Helix-turn-helix domains; Region: HTH; cl00088 288681002397 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288681002398 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681002399 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 288681002400 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 288681002401 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 288681002402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002404 putative substrate translocation pore; other site 288681002405 intracellular protease, PfpI family; Region: PfpI; TIGR01382 288681002406 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 288681002407 proposed catalytic triad [active] 288681002408 conserved cys residue [active] 288681002409 hydroperoxidase II; Provisional; Region: katE; PRK11249 288681002410 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 288681002411 tetramer interface [polypeptide binding]; other site 288681002412 heme binding pocket [chemical binding]; other site 288681002413 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 288681002414 domain interactions; other site 288681002415 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 288681002416 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 288681002417 Spore germination protein; Region: Spore_permease; cl15802 288681002418 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 288681002419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681002420 tetrameric interface [polypeptide binding]; other site 288681002421 activator binding site; other site 288681002422 NADP binding site [chemical binding]; other site 288681002423 substrate binding site [chemical binding]; other site 288681002424 catalytic residues [active] 288681002425 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681002426 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 288681002427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002428 Walker A/P-loop; other site 288681002429 ATP binding site [chemical binding]; other site 288681002430 Q-loop/lid; other site 288681002431 ABC transporter signature motif; other site 288681002432 Walker B; other site 288681002433 D-loop; other site 288681002434 H-loop/switch region; other site 288681002435 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681002436 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 288681002437 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681002438 Walker A/P-loop; other site 288681002439 ATP binding site [chemical binding]; other site 288681002440 Q-loop/lid; other site 288681002441 ABC transporter signature motif; other site 288681002442 Walker B; other site 288681002443 D-loop; other site 288681002444 H-loop/switch region; other site 288681002445 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681002446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681002447 substrate binding pocket [chemical binding]; other site 288681002448 membrane-bound complex binding site; other site 288681002449 hinge residues; other site 288681002450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002451 dimer interface [polypeptide binding]; other site 288681002452 conserved gate region; other site 288681002453 putative PBP binding loops; other site 288681002454 ABC-ATPase subunit interface; other site 288681002455 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681002456 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 288681002457 Walker A/P-loop; other site 288681002458 ATP binding site [chemical binding]; other site 288681002459 Q-loop/lid; other site 288681002460 ABC transporter signature motif; other site 288681002461 Walker B; other site 288681002462 D-loop; other site 288681002463 H-loop/switch region; other site 288681002464 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681002465 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681002466 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681002467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 288681002468 Protein of unknown function (DUF964); Region: DUF964; cl01483 288681002469 Haemolysin-III related; Region: HlyIII; cl03831 288681002470 Histidine kinase; Region: HisKA_3; pfam07730 288681002471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002472 ATP binding site [chemical binding]; other site 288681002473 Mg2+ binding site [ion binding]; other site 288681002474 G-X-G motif; other site 288681002475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681002476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002477 active site 288681002478 phosphorylation site [posttranslational modification] 288681002479 intermolecular recognition site; other site 288681002480 dimerization interface [polypeptide binding]; other site 288681002481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681002482 dimerization interface [polypeptide binding]; other site 288681002483 DNA binding residues [nucleotide binding] 288681002484 WxL domain surface cell wall-binding; Region: WxL; pfam13731 288681002485 WxL domain surface cell wall-binding; Region: WxL; pfam13731 288681002486 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 288681002487 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 288681002488 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 288681002489 acetolactate synthase; Reviewed; Region: PRK08617 288681002490 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681002491 PYR/PP interface [polypeptide binding]; other site 288681002492 dimer interface [polypeptide binding]; other site 288681002493 TPP binding site [chemical binding]; other site 288681002494 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681002495 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 288681002496 TPP-binding site [chemical binding]; other site 288681002497 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 288681002498 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 288681002499 active site 288681002500 DNA binding site [nucleotide binding] 288681002501 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681002502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681002503 active site 288681002504 motif I; other site 288681002505 motif II; other site 288681002506 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681002507 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 288681002508 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681002509 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681002510 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681002511 amidase catalytic site [active] 288681002512 Zn binding residues [ion binding]; other site 288681002513 substrate binding site [chemical binding]; other site 288681002514 S-layer homology domain; Region: SLH; pfam00395 288681002515 S-layer homology domain; Region: SLH; pfam00395 288681002516 S-layer homology domain; Region: SLH; pfam00395 288681002517 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 288681002518 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 288681002519 AMP-binding enzyme; Region: AMP-binding; cl15778 288681002520 AMP-binding enzyme; Region: AMP-binding; cl15778 288681002521 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 288681002522 Sulfate transporter family; Region: Sulfate_transp; cl15842 288681002523 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681002524 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 288681002525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002526 ATP binding site [chemical binding]; other site 288681002527 putative Mg++ binding site [ion binding]; other site 288681002528 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 288681002529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681002530 nucleotide binding region [chemical binding]; other site 288681002531 ATP-binding site [chemical binding]; other site 288681002532 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681002533 MatE; Region: MatE; cl10513 288681002534 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 288681002535 S-layer homology domain; Region: SLH; pfam00395 288681002536 S-layer homology domain; Region: SLH; pfam00395 288681002537 S-layer homology domain; Region: SLH; pfam00395 288681002538 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 288681002539 S-layer homology domain; Region: SLH; pfam00395 288681002540 S-layer homology domain; Region: SLH; pfam00395 288681002541 S-layer homology domain; Region: SLH; pfam00395 288681002542 DHHW protein; Region: DHHW; pfam14286 288681002543 DHHW protein; Region: DHHW; pfam14286 288681002544 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 288681002545 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 288681002546 enoyl-CoA hydratase; Provisional; Region: PRK07659 288681002547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681002548 substrate binding site [chemical binding]; other site 288681002549 oxyanion hole (OAH) forming residues; other site 288681002550 trimer interface [polypeptide binding]; other site 288681002551 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 288681002552 metal binding site [ion binding]; metal-binding site 288681002553 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681002554 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 288681002555 putative oligomer interface [polypeptide binding]; other site 288681002556 putative active site [active] 288681002557 metal binding site [ion binding]; metal-binding site 288681002558 S-layer homology domain; Region: SLH; pfam00395 288681002559 S-layer homology domain; Region: SLH; pfam00395 288681002560 S-layer homology domain; Region: SLH; pfam00395 288681002561 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681002562 active site 288681002563 metal binding site [ion binding]; metal-binding site 288681002564 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 288681002565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681002566 S-adenosylmethionine binding site [chemical binding]; other site 288681002567 proline racemase; Provisional; Region: PRK13969 288681002568 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681002569 ornithine cyclodeaminase; Validated; Region: PRK08618 288681002570 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288681002571 NAD(P) binding site [chemical binding]; other site 288681002572 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288681002573 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288681002574 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681002575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002576 dimer interface [polypeptide binding]; other site 288681002577 conserved gate region; other site 288681002578 putative PBP binding loops; other site 288681002579 ABC-ATPase subunit interface; other site 288681002580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681002581 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681002582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002583 dimer interface [polypeptide binding]; other site 288681002584 conserved gate region; other site 288681002585 putative PBP binding loops; other site 288681002586 ABC-ATPase subunit interface; other site 288681002587 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681002588 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681002589 Walker A/P-loop; other site 288681002590 ATP binding site [chemical binding]; other site 288681002591 Q-loop/lid; other site 288681002592 ABC transporter signature motif; other site 288681002593 Walker B; other site 288681002594 D-loop; other site 288681002595 H-loop/switch region; other site 288681002596 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681002597 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 288681002598 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681002599 Walker A/P-loop; other site 288681002600 ATP binding site [chemical binding]; other site 288681002601 Q-loop/lid; other site 288681002602 ABC transporter signature motif; other site 288681002603 Walker B; other site 288681002604 D-loop; other site 288681002605 H-loop/switch region; other site 288681002606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681002607 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681002608 WYL domain; Region: WYL; cl14852 288681002609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002610 Dynamin family; Region: Dynamin_N; pfam00350 288681002611 G1 box; other site 288681002612 GTP/Mg2+ binding site [chemical binding]; other site 288681002613 G2 box; other site 288681002614 Switch I region; other site 288681002615 G3 box; other site 288681002616 Switch II region; other site 288681002617 G4 box; other site 288681002618 G5 box; other site 288681002619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002620 Dynamin family; Region: Dynamin_N; pfam00350 288681002621 G1 box; other site 288681002622 GTP/Mg2+ binding site [chemical binding]; other site 288681002623 G2 box; other site 288681002624 Switch I region; other site 288681002625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002626 G3 box; other site 288681002627 Switch II region; other site 288681002628 G4 box; other site 288681002629 G5 box; other site 288681002630 Domain of unknown function DUF87; Region: DUF87; pfam01935 288681002631 AAA-like domain; Region: AAA_10; pfam12846 288681002632 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 288681002633 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681002634 Protein of unknown function DUF91; Region: DUF91; cl00709 288681002635 Helix-turn-helix domains; Region: HTH; cl00088 288681002636 WYL domain; Region: WYL; cl14852 288681002637 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 288681002638 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 288681002639 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 288681002640 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 288681002641 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 288681002642 Domain of unknown function DUF87; Region: DUF87; pfam01935 288681002643 AAA-like domain; Region: AAA_10; pfam12846 288681002644 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 288681002645 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 288681002646 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681002647 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681002648 catalytic residue [active] 288681002649 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 288681002650 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 288681002651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002652 Walker A/P-loop; other site 288681002653 ATP binding site [chemical binding]; other site 288681002654 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288681002655 Active Sites [active] 288681002656 DNA-sulfur modification-associated; Region: DndB; cl14002 288681002657 Tic20-like protein; Region: Tic20; pfam09685 288681002658 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681002659 DNA binding residues [nucleotide binding] 288681002660 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681002661 dimer interface [polypeptide binding]; other site 288681002662 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 288681002663 metal binding site [ion binding]; metal-binding site 288681002664 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 288681002665 replicative DNA helicase; Provisional; Region: PRK06749 288681002666 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 288681002667 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 288681002668 Walker A motif; other site 288681002669 ATP binding site [chemical binding]; other site 288681002670 Walker B motif; other site 288681002671 DNA binding loops [nucleotide binding] 288681002672 Helix-turn-helix domains; Region: HTH; cl00088 288681002673 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681002674 C-terminal domain interface [polypeptide binding]; other site 288681002675 sugar binding site [chemical binding]; other site 288681002676 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681002677 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681002678 Predicted permease; Region: DUF318; pfam03773 288681002679 Predicted permeases [General function prediction only]; Region: COG0701 288681002680 Helix-turn-helix domains; Region: HTH; cl00088 288681002681 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 288681002682 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 288681002683 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681002684 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 288681002685 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 288681002686 CGNR zinc finger; Region: zf-CGNR; pfam11706 288681002687 HPP family; Region: HPP; pfam04982 288681002688 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 288681002689 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681002690 putative NAD(P) binding site [chemical binding]; other site 288681002691 active site 288681002692 putative substrate binding site [chemical binding]; other site 288681002693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681002694 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681002695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002696 Helix-turn-helix domains; Region: HTH; cl00088 288681002697 YmzC-like protein; Region: YmzC; pfam14157 288681002698 transcriptional antiterminator BglG; Provisional; Region: PRK09772 288681002699 CAT RNA binding domain; Region: CAT_RBD; cl03904 288681002700 PRD domain; Region: PRD; cl15445 288681002701 PRD domain; Region: PRD; cl15445 288681002702 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 288681002703 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681002704 active site turn [active] 288681002705 phosphorylation site [posttranslational modification] 288681002706 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681002707 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 288681002708 HPr interaction site; other site 288681002709 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681002710 active site 288681002711 phosphorylation site [posttranslational modification] 288681002712 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 288681002713 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681002714 Helix-turn-helix domains; Region: HTH; cl00088 288681002715 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 288681002716 ATP synthase I chain; Region: ATP_synt_I; cl09170 288681002717 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 288681002718 VanZ like family; Region: VanZ; cl01971 288681002719 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 288681002720 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 288681002721 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 288681002722 Helix-turn-helix domains; Region: HTH; cl00088 288681002723 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681002724 dihydroxyacetone kinase; Provisional; Region: PRK14479 288681002725 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 288681002726 DAK2 domain; Region: Dak2; cl03685 288681002727 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681002728 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681002729 Helix-turn-helix domains; Region: HTH; cl00088 288681002730 DAK2 domain; Region: Dak2; cl03685 288681002731 Bacterial SH3 domain; Region: SH3_3; cl02551 288681002732 CAAX protease self-immunity; Region: Abi; cl00558 288681002733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681002734 Zn2+ binding site [ion binding]; other site 288681002735 Mg2+ binding site [ion binding]; other site 288681002736 S-layer homology domain; Region: SLH; pfam00395 288681002737 S-layer homology domain; Region: SLH; pfam00395 288681002738 S-layer homology domain; Region: SLH; pfam00395 288681002739 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 288681002740 Helix-turn-helix domains; Region: HTH; cl00088 288681002741 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 288681002742 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 288681002743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002744 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681002745 active site 288681002746 metal binding site [ion binding]; metal-binding site 288681002747 Heat induced stress protein YflT; Region: YflT; pfam11181 288681002748 CsbD-like; Region: CsbD; cl15799 288681002749 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 288681002750 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 288681002751 anti sigma factor interaction site; other site 288681002752 regulatory phosphorylation site [posttranslational modification]; other site 288681002753 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 288681002754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002755 ATP binding site [chemical binding]; other site 288681002756 Mg2+ binding site [ion binding]; other site 288681002757 G-X-G motif; other site 288681002758 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 288681002759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681002760 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681002761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681002762 DNA binding residues [nucleotide binding] 288681002763 Ferritin-like domain; Region: Ferritin; pfam00210 288681002764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 288681002765 dinuclear metal binding motif [ion binding]; other site 288681002766 Response regulator receiver domain; Region: Response_reg; pfam00072 288681002767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002768 active site 288681002769 phosphorylation site [posttranslational modification] 288681002770 intermolecular recognition site; other site 288681002771 dimerization interface [polypeptide binding]; other site 288681002772 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 288681002773 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681002774 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 288681002775 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 288681002776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681002777 CHASE3 domain; Region: CHASE3; cl05000 288681002778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681002779 GAF domain; Region: GAF_2; pfam13185 288681002780 GAF domain; Region: GAF; cl15785 288681002781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681002782 dimer interface [polypeptide binding]; other site 288681002783 phosphorylation site [posttranslational modification] 288681002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002785 ATP binding site [chemical binding]; other site 288681002786 Mg2+ binding site [ion binding]; other site 288681002787 G-X-G motif; other site 288681002788 Response regulator receiver domain; Region: Response_reg; pfam00072 288681002789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002790 active site 288681002791 phosphorylation site [posttranslational modification] 288681002792 intermolecular recognition site; other site 288681002793 dimerization interface [polypeptide binding]; other site 288681002794 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 288681002795 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 288681002796 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 288681002797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002799 active site 288681002800 phosphorylation site [posttranslational modification] 288681002801 intermolecular recognition site; other site 288681002802 dimerization interface [polypeptide binding]; other site 288681002803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681002804 DNA binding site [nucleotide binding] 288681002805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681002806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681002807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681002808 dimer interface [polypeptide binding]; other site 288681002809 phosphorylation site [posttranslational modification] 288681002810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002811 ATP binding site [chemical binding]; other site 288681002812 Mg2+ binding site [ion binding]; other site 288681002813 G-X-G motif; other site 288681002814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681002815 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681002816 Walker A/P-loop; other site 288681002817 ATP binding site [chemical binding]; other site 288681002818 Q-loop/lid; other site 288681002819 ABC transporter signature motif; other site 288681002820 Walker B; other site 288681002821 D-loop; other site 288681002822 H-loop/switch region; other site 288681002823 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681002824 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681002825 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681002826 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681002827 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 288681002828 NADP binding site [chemical binding]; other site 288681002829 dimer interface [polypeptide binding]; other site 288681002830 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 288681002831 YhzD-like protein; Region: YhzD; pfam14120 288681002832 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 288681002833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681002834 active site 288681002835 metal binding site [ion binding]; metal-binding site 288681002836 DNA binding site [nucleotide binding] 288681002837 AAA domain; Region: AAA_27; pfam13514 288681002838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002839 Q-loop/lid; other site 288681002840 ABC transporter signature motif; other site 288681002841 Walker B; other site 288681002842 D-loop; other site 288681002843 H-loop/switch region; other site 288681002844 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 288681002845 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 288681002846 generic binding surface II; other site 288681002847 generic binding surface I; other site 288681002848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681002849 Zn2+ binding site [ion binding]; other site 288681002850 Mg2+ binding site [ion binding]; other site 288681002851 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681002852 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681002853 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 288681002854 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681002855 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 288681002856 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681002857 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002858 Zn binding site [ion binding]; other site 288681002859 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681002860 Zn binding site [ion binding]; other site 288681002861 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681002862 Zn binding site [ion binding]; other site 288681002863 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681002864 Zn binding site [ion binding]; other site 288681002865 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681002866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681002867 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 288681002868 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002869 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002870 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 288681002871 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 288681002872 amphipathic channel; other site 288681002873 Asn-Pro-Ala signature motifs; other site 288681002874 glycerol kinase; Provisional; Region: glpK; PRK00047 288681002875 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 288681002876 N- and C-terminal domain interface [polypeptide binding]; other site 288681002877 active site 288681002878 MgATP binding site [chemical binding]; other site 288681002879 catalytic site [active] 288681002880 metal binding site [ion binding]; metal-binding site 288681002881 glycerol binding site [chemical binding]; other site 288681002882 homotetramer interface [polypeptide binding]; other site 288681002883 homodimer interface [polypeptide binding]; other site 288681002884 FBP binding site [chemical binding]; other site 288681002885 protein IIAGlc interface [polypeptide binding]; other site 288681002886 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288681002887 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 288681002888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681002889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681002890 DNA binding residues [nucleotide binding] 288681002891 Helix-turn-helix domains; Region: HTH; cl00088 288681002892 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681002893 Helix-turn-helix domains; Region: HTH; cl00088 288681002894 DoxX; Region: DoxX; cl00976 288681002895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002896 putative substrate translocation pore; other site 288681002897 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681002898 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681002899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002900 putative substrate translocation pore; other site 288681002901 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 288681002902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681002903 Family description; Region: UvrD_C_2; cl15862 288681002904 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 288681002905 PPIC-type PPIASE domain; Region: Rotamase; cl08278 288681002906 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 288681002907 transcriptional regulator Hpr; Provisional; Region: PRK13777 288681002908 Helix-turn-helix domains; Region: HTH; cl00088 288681002909 YtxH-like protein; Region: YtxH; cl02079 288681002910 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 288681002911 HIT family signature motif; other site 288681002912 catalytic residue [active] 288681002913 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681002914 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681002915 Walker A/P-loop; other site 288681002916 ATP binding site [chemical binding]; other site 288681002917 Q-loop/lid; other site 288681002918 ABC transporter signature motif; other site 288681002919 Walker B; other site 288681002920 D-loop; other site 288681002921 H-loop/switch region; other site 288681002922 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 288681002923 EcsC protein family; Region: EcsC; pfam12787 288681002924 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 288681002925 lipase class 3 family protein; Provisional; Region: PLN03037 288681002926 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 288681002927 nucleophilic elbow; other site 288681002928 catalytic triad; other site 288681002929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002930 Helix-turn-helix domains; Region: HTH; cl00088 288681002931 Bacterial PH domain; Region: DUF304; cl01348 288681002932 Predicted membrane protein [Function unknown]; Region: COG3428 288681002933 Bacterial PH domain; Region: DUF304; cl01348 288681002934 Bacterial PH domain; Region: DUF304; cl01348 288681002935 Bacterial PH domain; Region: DUF304; cl01348 288681002936 S-layer homology domain; Region: SLH; pfam00395 288681002937 S-layer homology domain; Region: SLH; pfam00395 288681002938 S-layer homology domain; Region: SLH; pfam00395 288681002939 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 288681002940 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 288681002941 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 288681002942 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681002943 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681002944 DNA binding residues [nucleotide binding] 288681002945 drug binding residues [chemical binding]; other site 288681002946 dimer interface [polypeptide binding]; other site 288681002947 Bacterial PH domain; Region: DUF304; cl01348 288681002948 Predicted membrane protein [Function unknown]; Region: COG3428 288681002949 Bacterial PH domain; Region: DUF304; cl01348 288681002950 Bacterial PH domain; Region: DUF304; cl01348 288681002951 Bacterial PH domain; Region: DUF304; cl01348 288681002952 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681002953 Transglycosylase; Region: Transgly; cl07896 288681002954 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681002955 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681002956 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 288681002957 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 288681002958 substrate binding site [chemical binding]; other site 288681002959 active site 288681002960 ferrochelatase; Provisional; Region: PRK12435 288681002961 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 288681002962 C-terminal domain interface [polypeptide binding]; other site 288681002963 active site 288681002964 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 288681002965 active site 288681002966 N-terminal domain interface [polypeptide binding]; other site 288681002967 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 288681002968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681002969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681002970 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 288681002971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 288681002972 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 288681002973 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 288681002974 generic binding surface II; other site 288681002975 generic binding surface I; other site 288681002976 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 288681002977 putative active site [active] 288681002978 putative catalytic site [active] 288681002979 putative Mg binding site IVb [ion binding]; other site 288681002980 putative phosphate binding site [ion binding]; other site 288681002981 putative DNA binding site [nucleotide binding]; other site 288681002982 putative Mg binding site IVa [ion binding]; other site 288681002983 Helix-turn-helix domains; Region: HTH; cl00088 288681002984 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 288681002985 Helix-turn-helix domains; Region: HTH; cl00088 288681002986 Predicted membrane protein [Function unknown]; Region: COG1511 288681002987 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681002988 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 288681002989 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 288681002990 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681002991 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 288681002992 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681002993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681002994 Coenzyme A binding pocket [chemical binding]; other site 288681002995 DinB superfamily; Region: DinB_2; pfam12867 288681002996 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 288681002997 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681002998 Helix-turn-helix domains; Region: HTH; cl00088 288681002999 WYL domain; Region: WYL; cl14852 288681003000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681003001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681003002 DNA binding site [nucleotide binding] 288681003003 domain linker motif; other site 288681003004 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681003005 putative dimerization interface [polypeptide binding]; other site 288681003006 putative ligand binding site [chemical binding]; other site 288681003007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681003008 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 288681003009 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 288681003010 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 288681003011 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 288681003012 AMP-binding enzyme; Region: AMP-binding; cl15778 288681003013 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681003014 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681003015 heme-binding site [chemical binding]; other site 288681003016 S-layer homology domain; Region: SLH; pfam00395 288681003017 S-layer homology domain; Region: SLH; pfam00395 288681003018 S-layer homology domain; Region: SLH; pfam00395 288681003019 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 288681003020 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 288681003021 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681003022 putative active site [active] 288681003023 putative metal binding site [ion binding]; other site 288681003024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681003025 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681003026 Putative zinc-finger; Region: zf-HC2; cl15806 288681003027 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681003028 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681003029 RNA polymerase sigma factor; Provisional; Region: PRK12541 288681003030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681003031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681003032 DNA binding residues [nucleotide binding] 288681003033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681003034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681003035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681003036 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681003037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681003038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681003039 active site 288681003040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003041 dimer interface [polypeptide binding]; other site 288681003042 phosphorylation site [posttranslational modification] 288681003043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003044 ATP binding site [chemical binding]; other site 288681003045 Mg2+ binding site [ion binding]; other site 288681003046 G-X-G motif; other site 288681003047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681003048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003049 active site 288681003050 phosphorylation site [posttranslational modification] 288681003051 intermolecular recognition site; other site 288681003052 dimerization interface [polypeptide binding]; other site 288681003053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681003054 DNA binding site [nucleotide binding] 288681003055 CAAX protease self-immunity; Region: Abi; cl00558 288681003056 Peptidase family M48; Region: Peptidase_M48; cl12018 288681003057 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681003058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003059 dimerization interface [polypeptide binding]; other site 288681003060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681003061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681003062 dimer interface [polypeptide binding]; other site 288681003063 putative CheW interface [polypeptide binding]; other site 288681003064 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681003065 EamA-like transporter family; Region: EamA; cl01037 288681003066 EamA-like transporter family; Region: EamA; cl01037 288681003067 S-layer homology domain; Region: SLH; pfam00395 288681003068 S-layer homology domain; Region: SLH; pfam00395 288681003069 S-layer homology domain; Region: SLH; pfam00395 288681003070 S-layer homology domain; Region: SLH; pfam00395 288681003071 S-layer homology domain; Region: SLH; pfam00395 288681003072 S-layer homology domain; Region: SLH; pfam00395 288681003073 S-layer homology domain; Region: SLH; pfam00395 288681003074 S-layer homology domain; Region: SLH; pfam00395 288681003075 S-layer homology domain; Region: SLH; pfam00395 288681003076 malate synthase A; Region: malate_syn_A; TIGR01344 288681003077 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 288681003078 active site 288681003079 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 288681003080 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681003081 tetramer interface [polypeptide binding]; other site 288681003082 active site 288681003083 Mg2+/Mn2+ binding site [ion binding]; other site 288681003084 Phosphotransferase enzyme family; Region: APH; pfam01636 288681003085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 288681003086 active site 288681003087 substrate binding site [chemical binding]; other site 288681003088 ATP binding site [chemical binding]; other site 288681003089 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681003090 DNA-binding site [nucleotide binding]; DNA binding site 288681003091 RNA-binding motif; other site 288681003092 ComK protein; Region: ComK; cl11560 288681003093 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681003094 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681003095 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681003096 Catalytic site [active] 288681003097 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 288681003098 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 288681003099 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 288681003100 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 288681003101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681003102 Family description; Region: UvrD_C_2; cl15862 288681003103 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 288681003104 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 288681003105 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681003106 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 288681003107 Spore germination protein GerPC; Region: GerPC; pfam10737 288681003108 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 288681003109 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681003110 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681003111 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 288681003112 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 288681003113 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681003114 inhibitor-cofactor binding pocket; inhibition site 288681003115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003116 catalytic residue [active] 288681003117 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 288681003118 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 288681003119 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 288681003120 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681003121 dimer interface [polypeptide binding]; other site 288681003122 active site 288681003123 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681003124 Ligand Binding Site [chemical binding]; other site 288681003125 Molecular Tunnel; other site 288681003126 ferrochelatase; Provisional; Region: PRK12435 288681003127 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 288681003128 C-terminal domain interface [polypeptide binding]; other site 288681003129 active site 288681003130 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 288681003131 active site 288681003132 N-terminal domain interface [polypeptide binding]; other site 288681003133 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681003134 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681003135 tetramer interface [polypeptide binding]; other site 288681003136 heme binding pocket [chemical binding]; other site 288681003137 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 288681003138 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288681003139 active site 288681003140 catalytic site [active] 288681003141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003142 non-specific DNA binding site [nucleotide binding]; other site 288681003143 salt bridge; other site 288681003144 sequence-specific DNA binding site [nucleotide binding]; other site 288681003145 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681003146 Protein of unknown function (DUF520); Region: DUF520; cl00723 288681003147 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 288681003148 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681003149 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 288681003150 PPIC-type PPIASE domain; Region: Rotamase; cl08278 288681003151 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681003152 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681003153 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681003154 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681003155 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 288681003156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681003157 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681003158 active site 288681003159 motif I; other site 288681003160 motif II; other site 288681003161 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681003162 YjzC-like protein; Region: YjzC; pfam14168 288681003163 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 288681003164 Clp amino terminal domain; Region: Clp_N; pfam02861 288681003165 Clp amino terminal domain; Region: Clp_N; pfam02861 288681003166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681003167 Walker A motif; other site 288681003168 ATP binding site [chemical binding]; other site 288681003169 Walker B motif; other site 288681003170 arginine finger; other site 288681003171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681003172 Walker A motif; other site 288681003173 ATP binding site [chemical binding]; other site 288681003174 Walker B motif; other site 288681003175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 288681003176 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 288681003177 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 288681003178 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681003179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003180 NAD(P) binding site [chemical binding]; other site 288681003181 active site 288681003182 ComZ; Region: ComZ; pfam10815 288681003183 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 288681003184 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681003185 dimer interface [polypeptide binding]; other site 288681003186 active site 288681003187 CoA binding pocket [chemical binding]; other site 288681003188 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 288681003189 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 288681003190 dimer interface [polypeptide binding]; other site 288681003191 active site 288681003192 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 288681003193 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 288681003194 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 288681003195 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288681003196 active site 288681003197 HIGH motif; other site 288681003198 dimer interface [polypeptide binding]; other site 288681003199 KMSKS motif; other site 288681003200 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 288681003201 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681003202 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681003203 peptide binding site [polypeptide binding]; other site 288681003204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003206 dimer interface [polypeptide binding]; other site 288681003207 conserved gate region; other site 288681003208 putative PBP binding loops; other site 288681003209 ABC-ATPase subunit interface; other site 288681003210 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681003211 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 288681003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003213 dimer interface [polypeptide binding]; other site 288681003214 conserved gate region; other site 288681003215 putative PBP binding loops; other site 288681003216 ABC-ATPase subunit interface; other site 288681003217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681003218 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681003219 Walker A/P-loop; other site 288681003220 ATP binding site [chemical binding]; other site 288681003221 Q-loop/lid; other site 288681003222 ABC transporter signature motif; other site 288681003223 Walker B; other site 288681003224 D-loop; other site 288681003225 H-loop/switch region; other site 288681003226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681003227 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 288681003228 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681003229 Walker A/P-loop; other site 288681003230 ATP binding site [chemical binding]; other site 288681003231 Q-loop/lid; other site 288681003232 ABC transporter signature motif; other site 288681003233 Walker B; other site 288681003234 D-loop; other site 288681003235 H-loop/switch region; other site 288681003236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681003237 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681003238 MatE; Region: MatE; cl10513 288681003239 MatE; Region: MatE; cl10513 288681003240 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681003241 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681003242 peptide binding site [polypeptide binding]; other site 288681003243 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 288681003244 ArsC family; Region: ArsC; pfam03960 288681003245 putative catalytic residues [active] 288681003246 thiol/disulfide switch; other site 288681003247 Integral membrane protein TerC family; Region: TerC; cl10468 288681003248 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 288681003249 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 288681003250 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288681003251 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681003252 putative active site [active] 288681003253 catalytic site [active] 288681003254 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681003255 putative active site [active] 288681003256 catalytic site [active] 288681003257 Competence protein CoiA-like family; Region: CoiA; cl11541 288681003258 oligoendopeptidase F; Region: pepF; TIGR00181 288681003259 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 288681003260 active site 288681003261 Zn binding site [ion binding]; other site 288681003262 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 288681003263 Thioredoxin; Region: Thioredoxin_5; pfam13743 288681003264 catalytic residues [active] 288681003265 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 288681003266 apolar tunnel; other site 288681003267 heme binding site [chemical binding]; other site 288681003268 dimerization interface [polypeptide binding]; other site 288681003269 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 288681003270 putative active site [active] 288681003271 putative metal binding residues [ion binding]; other site 288681003272 signature motif; other site 288681003273 putative triphosphate binding site [ion binding]; other site 288681003274 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681003275 synthetase active site [active] 288681003276 NTP binding site [chemical binding]; other site 288681003277 metal binding site [ion binding]; metal-binding site 288681003278 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 288681003279 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288681003280 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681003281 active site 288681003282 Hep_Hag; Region: Hep_Hag; pfam05658 288681003283 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 288681003284 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 288681003285 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 288681003286 active site 288681003287 metal binding site [ion binding]; metal-binding site 288681003288 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681003289 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681003290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681003291 active site 288681003292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003293 S-adenosylmethionine binding site [chemical binding]; other site 288681003294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681003295 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 288681003296 putative metal binding site; other site 288681003297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681003298 binding surface 288681003299 TPR motif; other site 288681003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003301 S-adenosylmethionine binding site [chemical binding]; other site 288681003302 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 288681003303 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 288681003304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681003305 active site 288681003306 Cupin domain; Region: Cupin_2; cl09118 288681003307 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 288681003308 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 288681003309 NAD binding site [chemical binding]; other site 288681003310 substrate binding site [chemical binding]; other site 288681003311 homodimer interface [polypeptide binding]; other site 288681003312 active site 288681003313 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 288681003314 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 288681003315 NADP binding site [chemical binding]; other site 288681003316 active site 288681003317 putative substrate binding site [chemical binding]; other site 288681003318 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 288681003319 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 288681003320 NAD binding site [chemical binding]; other site 288681003321 homotetramer interface [polypeptide binding]; other site 288681003322 homodimer interface [polypeptide binding]; other site 288681003323 substrate binding site [chemical binding]; other site 288681003324 active site 288681003325 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 288681003326 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 288681003327 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 288681003328 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 288681003329 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 288681003330 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 288681003331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681003332 Family description; Region: UvrD_C_2; cl15862 288681003333 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681003334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003335 Coenzyme A binding pocket [chemical binding]; other site 288681003336 hypothetical protein; Provisional; Region: PRK13679 288681003337 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681003338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681003339 Putative esterase; Region: Esterase; pfam00756 288681003340 EamA-like transporter family; Region: EamA; cl01037 288681003341 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681003342 EamA-like transporter family; Region: EamA; cl01037 288681003343 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681003344 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 288681003345 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 288681003346 Na binding site [ion binding]; other site 288681003347 anthranilate synthase component I; Provisional; Region: PRK13570 288681003348 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288681003349 chorismate binding enzyme; Region: Chorismate_bind; cl10555 288681003350 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 288681003351 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 288681003352 glutamine binding [chemical binding]; other site 288681003353 catalytic triad [active] 288681003354 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 288681003355 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681003356 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681003357 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 288681003358 active site 288681003359 ribulose/triose binding site [chemical binding]; other site 288681003360 phosphate binding site [ion binding]; other site 288681003361 substrate (anthranilate) binding pocket [chemical binding]; other site 288681003362 product (indole) binding pocket [chemical binding]; other site 288681003363 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 288681003364 active site 288681003365 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 288681003366 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 288681003367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003368 catalytic residue [active] 288681003369 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 288681003370 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 288681003371 substrate binding site [chemical binding]; other site 288681003372 active site 288681003373 catalytic residues [active] 288681003374 heterodimer interface [polypeptide binding]; other site 288681003375 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 288681003376 L-lactate permease; Region: Lactate_perm; cl00701 288681003377 Uncharacterized conserved protein [Function unknown]; Region: COG5634 288681003378 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 288681003379 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 288681003380 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 288681003381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681003382 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681003383 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681003384 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 288681003385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003386 S-adenosylmethionine binding site [chemical binding]; other site 288681003387 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681003388 NADPH bind site [chemical binding]; other site 288681003389 putative FMN binding site [chemical binding]; other site 288681003390 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681003391 putative FMN binding site [chemical binding]; other site 288681003392 NADPH bind site [chemical binding]; other site 288681003393 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 288681003394 YcaO-like family; Region: YcaO; pfam02624 288681003395 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 288681003396 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 288681003397 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 288681003398 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 288681003399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681003400 E3 interaction surface; other site 288681003401 lipoyl attachment site [posttranslational modification]; other site 288681003402 e3 binding domain; Region: E3_binding; pfam02817 288681003403 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 288681003404 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 288681003405 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 288681003406 TPP-binding site [chemical binding]; other site 288681003407 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 288681003408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003409 salt bridge; other site 288681003410 non-specific DNA binding site [nucleotide binding]; other site 288681003411 sequence-specific DNA binding site [nucleotide binding]; other site 288681003412 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 288681003413 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681003414 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 288681003415 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 288681003416 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 288681003417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003418 S-adenosylmethionine binding site [chemical binding]; other site 288681003419 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681003420 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 288681003421 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 288681003422 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681003423 Catalytic site [active] 288681003424 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681003425 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 288681003426 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681003427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003428 non-specific DNA binding site [nucleotide binding]; other site 288681003429 salt bridge; other site 288681003430 sequence-specific DNA binding site [nucleotide binding]; other site 288681003431 Anti-repressor SinI; Region: SinI; pfam08671 288681003432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 288681003433 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 288681003434 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 288681003435 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 288681003436 NAD(P) binding site [chemical binding]; other site 288681003437 catalytic residues [active] 288681003438 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 288681003439 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 288681003440 Walker A/P-loop; other site 288681003441 ATP binding site [chemical binding]; other site 288681003442 Q-loop/lid; other site 288681003443 ABC transporter signature motif; other site 288681003444 Walker B; other site 288681003445 D-loop; other site 288681003446 H-loop/switch region; other site 288681003447 TOBE domain; Region: TOBE_2; cl01440 288681003448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003449 dimer interface [polypeptide binding]; other site 288681003450 conserved gate region; other site 288681003451 putative PBP binding loops; other site 288681003452 ABC-ATPase subunit interface; other site 288681003453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 288681003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003455 dimer interface [polypeptide binding]; other site 288681003456 conserved gate region; other site 288681003457 putative PBP binding loops; other site 288681003458 ABC-ATPase subunit interface; other site 288681003459 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 288681003460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681003461 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 288681003462 active site 288681003463 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 288681003464 Protein export membrane protein; Region: SecD_SecF; cl14618 288681003465 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681003466 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288681003467 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681003468 active site 288681003469 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681003470 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 288681003471 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681003472 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 288681003473 Cysteine-rich domain; Region: CCG; pfam02754 288681003474 Cysteine-rich domain; Region: CCG; pfam02754 288681003475 FAD binding domain; Region: FAD_binding_4; pfam01565 288681003476 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 288681003477 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 288681003478 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 288681003479 Helix-turn-helix domains; Region: HTH; cl00088 288681003480 Uncharacterized conserved protein [Function unknown]; Region: COG3391 288681003481 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 288681003482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 288681003483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681003484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003485 active site 288681003486 phosphorylation site [posttranslational modification] 288681003487 intermolecular recognition site; other site 288681003488 dimerization interface [polypeptide binding]; other site 288681003489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681003490 DNA binding site [nucleotide binding] 288681003491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003492 dimerization interface [polypeptide binding]; other site 288681003493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003494 dimer interface [polypeptide binding]; other site 288681003495 phosphorylation site [posttranslational modification] 288681003496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003497 ATP binding site [chemical binding]; other site 288681003498 Mg2+ binding site [ion binding]; other site 288681003499 G-X-G motif; other site 288681003500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681003501 DNA-binding site [nucleotide binding]; DNA binding site 288681003502 FCD domain; Region: FCD; cl11656 288681003503 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 288681003504 Cysteine-rich domain; Region: CCG; pfam02754 288681003505 Cysteine-rich domain; Region: CCG; pfam02754 288681003506 iron-sulfur cluster-binding protein; Region: TIGR00273 288681003507 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 288681003508 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 288681003509 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 288681003510 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 288681003511 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 288681003512 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 288681003513 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 288681003514 Integral membrane protein TerC family; Region: TerC; cl10468 288681003515 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003516 Cation transport protein; Region: TrkH; cl10514 288681003517 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681003518 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 288681003519 dimer interaction site [polypeptide binding]; other site 288681003520 substrate-binding tunnel; other site 288681003521 active site 288681003522 catalytic site [active] 288681003523 substrate binding site [chemical binding]; other site 288681003524 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 288681003525 Helix-turn-helix domains; Region: HTH; cl00088 288681003526 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 288681003527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288681003528 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288681003529 NAD(P) binding site [chemical binding]; other site 288681003530 homotetramer interface [polypeptide binding]; other site 288681003531 homodimer interface [polypeptide binding]; other site 288681003532 active site 288681003533 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 288681003534 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 288681003535 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 288681003536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003537 FAD dependent oxidoreductase; Region: DAO; pfam01266 288681003538 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003539 Cation transport protein; Region: TrkH; cl10514 288681003540 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 288681003541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681003542 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 288681003543 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 288681003544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681003545 Walker A/P-loop; other site 288681003546 ATP binding site [chemical binding]; other site 288681003547 Q-loop/lid; other site 288681003548 ABC transporter signature motif; other site 288681003549 Walker B; other site 288681003550 D-loop; other site 288681003551 H-loop/switch region; other site 288681003552 TOBE domain; Region: TOBE_2; cl01440 288681003553 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 288681003554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003555 dimer interface [polypeptide binding]; other site 288681003556 conserved gate region; other site 288681003557 putative PBP binding loops; other site 288681003558 ABC-ATPase subunit interface; other site 288681003559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003560 dimer interface [polypeptide binding]; other site 288681003561 conserved gate region; other site 288681003562 putative PBP binding loops; other site 288681003563 ABC-ATPase subunit interface; other site 288681003564 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 288681003565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681003566 motif II; other site 288681003567 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681003568 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681003569 catalytic residue [active] 288681003570 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 288681003571 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681003572 Helix-turn-helix domains; Region: HTH; cl00088 288681003573 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681003574 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681003575 heme-binding site [chemical binding]; other site 288681003576 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003577 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 288681003578 Leucine rich repeat; Region: LRR_8; pfam13855 288681003579 Substrate binding site [chemical binding]; other site 288681003580 Leucine rich repeat; Region: LRR_8; pfam13855 288681003581 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003582 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003583 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003584 Leucine rich repeat; Region: LRR_8; pfam13855 288681003585 S-layer homology domain; Region: SLH; pfam00395 288681003586 S-layer homology domain; Region: SLH; pfam00395 288681003587 S-layer homology domain; Region: SLH; pfam00395 288681003588 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 288681003589 intersubunit interface [polypeptide binding]; other site 288681003590 active site 288681003591 Zn2+ binding site [ion binding]; other site 288681003592 FOG: CBS domain [General function prediction only]; Region: COG0517 288681003593 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288681003594 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 288681003595 NodB motif; other site 288681003596 putative active site [active] 288681003597 putative catalytic site [active] 288681003598 Zn binding site [ion binding]; other site 288681003599 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681003600 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 288681003601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003602 dimer interface [polypeptide binding]; other site 288681003603 phosphorylation site [posttranslational modification] 288681003604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003605 ATP binding site [chemical binding]; other site 288681003606 Mg2+ binding site [ion binding]; other site 288681003607 G-X-G motif; other site 288681003608 Helix-turn-helix domains; Region: HTH; cl00088 288681003609 transcriptional regulator SlyA; Provisional; Region: PRK03573 288681003610 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681003611 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681003612 active site 288681003613 Zn binding site [ion binding]; other site 288681003614 DinB superfamily; Region: DinB_2; pfam12867 288681003615 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681003616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003617 dimer interface [polypeptide binding]; other site 288681003618 phosphorylation site [posttranslational modification] 288681003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003620 ATP binding site [chemical binding]; other site 288681003621 Mg2+ binding site [ion binding]; other site 288681003622 G-X-G motif; other site 288681003623 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 288681003624 Ligand Binding Site [chemical binding]; other site 288681003625 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 288681003626 active site 288681003627 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 288681003628 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 288681003629 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 288681003630 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 288681003631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003632 Coenzyme A binding pocket [chemical binding]; other site 288681003633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 288681003634 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681003635 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 288681003636 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 288681003637 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 288681003638 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 288681003639 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 288681003640 dimer interface [polypeptide binding]; other site 288681003641 putative radical transfer pathway; other site 288681003642 diiron center [ion binding]; other site 288681003643 tyrosyl radical; other site 288681003644 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681003645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681003646 DNA-binding site [nucleotide binding]; DNA binding site 288681003647 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681003648 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681003649 Walker A/P-loop; other site 288681003650 ATP binding site [chemical binding]; other site 288681003651 Q-loop/lid; other site 288681003652 ABC transporter signature motif; other site 288681003653 Walker B; other site 288681003654 D-loop; other site 288681003655 H-loop/switch region; other site 288681003656 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681003657 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681003658 Walker A/P-loop; other site 288681003659 ATP binding site [chemical binding]; other site 288681003660 Q-loop/lid; other site 288681003661 ABC transporter signature motif; other site 288681003662 Walker B; other site 288681003663 D-loop; other site 288681003664 H-loop/switch region; other site 288681003665 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681003666 CAAX protease self-immunity; Region: Abi; cl00558 288681003667 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681003668 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 288681003669 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 288681003670 Helix-turn-helix domains; Region: HTH; cl00088 288681003671 AsnC family; Region: AsnC_trans_reg; pfam01037 288681003672 Uncharacterized conserved protein [Function unknown]; Region: COG2128 288681003673 Isochorismatase family; Region: Isochorismatase; pfam00857 288681003674 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681003675 catalytic triad [active] 288681003676 conserved cis-peptide bond; other site 288681003677 SseB protein; Region: SseB; cl06279 288681003678 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 288681003679 dimer interface [polypeptide binding]; other site 288681003680 catalytic triad [active] 288681003681 Nitronate monooxygenase; Region: NMO; pfam03060 288681003682 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 288681003683 FMN binding site [chemical binding]; other site 288681003684 substrate binding site [chemical binding]; other site 288681003685 putative catalytic residue [active] 288681003686 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681003687 DltD N-terminal region; Region: DltD_N; pfam04915 288681003688 DltD central region; Region: DltD_M; pfam04918 288681003689 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288681003690 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681003691 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 288681003692 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 288681003693 AMP-binding enzyme; Region: AMP-binding; cl15778 288681003694 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 288681003695 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681003696 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 288681003697 metal binding site [ion binding]; metal-binding site 288681003698 dimer interface [polypeptide binding]; other site 288681003699 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681003700 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681003701 Phosphotransferase enzyme family; Region: APH; pfam01636 288681003702 active site 288681003703 substrate binding site [chemical binding]; other site 288681003704 ATP binding site [chemical binding]; other site 288681003705 multidrug efflux protein; Reviewed; Region: PRK01766 288681003706 MatE; Region: MatE; cl10513 288681003707 MatE; Region: MatE; cl10513 288681003708 Bacitracin resistance protein BacA; Region: BacA; cl00858 288681003709 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288681003710 Regulatory protein YrvL; Region: YrvL; pfam14184 288681003711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681003712 Helix-turn-helix domains; Region: HTH; cl00088 288681003713 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681003714 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681003715 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003716 Cation transport protein; Region: TrkH; cl10514 288681003717 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681003718 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 288681003719 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 288681003720 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681003721 homodimer interface [polypeptide binding]; other site 288681003722 substrate-cofactor binding pocket; other site 288681003723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003724 catalytic residue [active] 288681003725 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 288681003726 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681003727 PYR/PP interface [polypeptide binding]; other site 288681003728 dimer interface [polypeptide binding]; other site 288681003729 TPP binding site [chemical binding]; other site 288681003730 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681003731 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 288681003732 TPP-binding site [chemical binding]; other site 288681003733 dimer interface [polypeptide binding]; other site 288681003734 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 288681003735 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 288681003736 putative valine binding site [chemical binding]; other site 288681003737 dimer interface [polypeptide binding]; other site 288681003738 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 288681003739 ketol-acid reductoisomerase; Provisional; Region: PRK05479 288681003740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003741 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 288681003742 2-isopropylmalate synthase; Validated; Region: PRK00915 288681003743 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 288681003744 active site 288681003745 catalytic residues [active] 288681003746 metal binding site [ion binding]; metal-binding site 288681003747 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 288681003748 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 288681003749 tartrate dehydrogenase; Provisional; Region: PRK08194 288681003750 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 288681003751 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 288681003752 substrate binding site [chemical binding]; other site 288681003753 ligand binding site [chemical binding]; other site 288681003754 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 288681003755 substrate binding site [chemical binding]; other site 288681003756 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 288681003757 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 288681003758 dimer interface [polypeptide binding]; other site 288681003759 motif 1; other site 288681003760 active site 288681003761 motif 2; other site 288681003762 motif 3; other site 288681003763 ATP phosphoribosyltransferase; Region: HisG; cl15266 288681003764 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 288681003765 histidinol dehydrogenase; Region: hisD; TIGR00069 288681003766 NAD binding site [chemical binding]; other site 288681003767 dimerization interface [polypeptide binding]; other site 288681003768 product binding site; other site 288681003769 substrate binding site [chemical binding]; other site 288681003770 zinc binding site [ion binding]; other site 288681003771 catalytic residues [active] 288681003772 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 288681003773 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 288681003774 putative active site pocket [active] 288681003775 4-fold oligomerization interface [polypeptide binding]; other site 288681003776 metal binding residues [ion binding]; metal-binding site 288681003777 3-fold/trimer interface [polypeptide binding]; other site 288681003778 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 288681003779 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 288681003780 putative active site [active] 288681003781 oxyanion strand; other site 288681003782 catalytic triad [active] 288681003783 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 288681003784 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 288681003785 catalytic residues [active] 288681003786 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 288681003787 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 288681003788 substrate binding site [chemical binding]; other site 288681003789 glutamase interaction surface [polypeptide binding]; other site 288681003790 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 288681003791 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 288681003792 metal binding site [ion binding]; metal-binding site 288681003793 histidinol-phosphatase; Validated; Region: PRK06740 288681003794 glyoxylate reductase; Reviewed; Region: PRK13243 288681003795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003796 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 288681003797 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681003798 Sulfatase; Region: Sulfatase; cl10460 288681003799 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 288681003800 diaminopimelate decarboxylase; Region: lysA; TIGR01048 288681003801 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 288681003802 active site 288681003803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681003804 substrate binding site [chemical binding]; other site 288681003805 catalytic residues [active] 288681003806 dimer interface [polypeptide binding]; other site 288681003807 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288681003808 Active Sites [active] 288681003809 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 288681003810 ATP-sulfurylase; Region: ATPS; cd00517 288681003811 active site 288681003812 HXXH motif; other site 288681003813 flexible loop; other site 288681003814 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 288681003815 AAA domain; Region: AAA_18; pfam13238 288681003816 ligand-binding site [chemical binding]; other site 288681003817 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 288681003818 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681003819 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681003820 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 288681003821 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 288681003822 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 288681003823 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 288681003824 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 288681003825 putative active site [active] 288681003826 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 288681003827 putative active site [active] 288681003828 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 288681003829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003830 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681003831 Na2 binding site [ion binding]; other site 288681003832 putative substrate binding site 1 [chemical binding]; other site 288681003833 Na binding site 1 [ion binding]; other site 288681003834 putative substrate binding site 2 [chemical binding]; other site 288681003835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681003836 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681003837 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681003838 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681003839 Protein of unknown function (DUF402); Region: DUF402; cl00979 288681003840 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 288681003841 PspA/IM30 family; Region: PspA_IM30; pfam04012 288681003842 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 288681003843 Histidine kinase; Region: HisKA_3; pfam07730 288681003844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003845 ATP binding site [chemical binding]; other site 288681003846 Mg2+ binding site [ion binding]; other site 288681003847 G-X-G motif; other site 288681003848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681003849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003850 active site 288681003851 phosphorylation site [posttranslational modification] 288681003852 intermolecular recognition site; other site 288681003853 dimerization interface [polypeptide binding]; other site 288681003854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681003855 DNA binding residues [nucleotide binding] 288681003856 dimerization interface [polypeptide binding]; other site 288681003857 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 288681003858 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681003859 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 288681003860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003861 S-adenosylmethionine binding site [chemical binding]; other site 288681003862 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 288681003863 active site 288681003864 putative substrate binding region [chemical binding]; other site 288681003865 hypothetical protein; Provisional; Region: PRK06770 288681003866 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 288681003867 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 288681003868 heme-binding site [chemical binding]; other site 288681003869 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 288681003870 FAD binding pocket [chemical binding]; other site 288681003871 FAD binding motif [chemical binding]; other site 288681003872 phosphate binding motif [ion binding]; other site 288681003873 beta-alpha-beta structure motif; other site 288681003874 NAD binding pocket [chemical binding]; other site 288681003875 Heme binding pocket [chemical binding]; other site 288681003876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681003877 ligand binding site [chemical binding]; other site 288681003878 flexible hinge region; other site 288681003879 Helix-turn-helix domains; Region: HTH; cl00088 288681003880 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681003881 Phosphate transporter family; Region: PHO4; cl00396 288681003882 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 288681003883 Transglycosylase; Region: Transgly; cl07896 288681003884 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681003885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681003886 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 288681003887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681003888 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 288681003889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003890 dimer interface [polypeptide binding]; other site 288681003891 phosphorylation site [posttranslational modification] 288681003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003893 ATP binding site [chemical binding]; other site 288681003894 Mg2+ binding site [ion binding]; other site 288681003895 G-X-G motif; other site 288681003896 Protein of unknown function DUF72; Region: DUF72; cl00777 288681003897 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 288681003898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681003899 active site 288681003900 DNA binding site [nucleotide binding] 288681003901 Int/Topo IB signature motif; other site 288681003902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003903 dimerization interface [polypeptide binding]; other site 288681003904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003905 dimer interface [polypeptide binding]; other site 288681003906 phosphorylation site [posttranslational modification] 288681003907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003908 ATP binding site [chemical binding]; other site 288681003909 Mg2+ binding site [ion binding]; other site 288681003910 G-X-G motif; other site 288681003911 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288681003912 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 288681003913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681003914 Probable transposase; Region: OrfB_IS605; pfam01385 288681003915 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681003916 Predicted integral membrane protein [Function unknown]; Region: COG0392 288681003917 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 288681003918 Uncharacterized conserved protein [Function unknown]; Region: COG2898 288681003919 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 288681003920 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 288681003921 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681003922 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681003923 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681003924 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681003925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681003926 Nucleoside recognition; Region: Gate; cl00486 288681003927 Nucleoside recognition; Region: Gate; cl00486 288681003928 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681003929 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681003930 RNA binding surface [nucleotide binding]; other site 288681003931 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 288681003932 active site 288681003933 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681003934 catalytic residues [active] 288681003935 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 288681003936 ResB-like family; Region: ResB; pfam05140 288681003937 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681003938 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681003939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003941 active site 288681003942 phosphorylation site [posttranslational modification] 288681003943 intermolecular recognition site; other site 288681003944 dimerization interface [polypeptide binding]; other site 288681003945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681003946 DNA binding site [nucleotide binding] 288681003947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 288681003948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003949 dimerization interface [polypeptide binding]; other site 288681003950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681003951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003952 dimer interface [polypeptide binding]; other site 288681003953 phosphorylation site [posttranslational modification] 288681003954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003955 ATP binding site [chemical binding]; other site 288681003956 Mg2+ binding site [ion binding]; other site 288681003957 G-X-G motif; other site 288681003958 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 288681003959 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681003960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681003961 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681003962 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 288681003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 288681003964 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681003965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681003966 ATP binding site [chemical binding]; other site 288681003967 putative Mg++ binding site [ion binding]; other site 288681003968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681003969 nucleotide binding region [chemical binding]; other site 288681003970 ATP-binding site [chemical binding]; other site 288681003971 CAAX protease self-immunity; Region: Abi; cl00558 288681003972 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681003973 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 288681003974 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681003975 putative active site [active] 288681003976 putative metal binding site [ion binding]; other site 288681003977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681003978 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 288681003979 DNA binding residues [nucleotide binding] 288681003980 B12 binding domain; Region: B12-binding_2; cl03653 288681003981 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 288681003982 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 288681003983 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 288681003984 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 288681003985 NAD(P) binding site [chemical binding]; other site 288681003986 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 288681003987 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681003988 amidase catalytic site [active] 288681003989 Zn binding residues [ion binding]; other site 288681003990 substrate binding site [chemical binding]; other site 288681003991 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 288681003992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681003994 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 288681003995 active site 288681003996 homotetramer interface [polypeptide binding]; other site 288681003997 homodimer interface [polypeptide binding]; other site 288681003998 cytidylate kinase; Provisional; Region: cmk; PRK00023 288681003999 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 288681004000 CMP-binding site; other site 288681004001 The sites determining sugar specificity; other site 288681004002 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 288681004003 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 288681004004 RNA binding site [nucleotide binding]; other site 288681004005 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 288681004006 RNA binding site [nucleotide binding]; other site 288681004007 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 288681004008 RNA binding site [nucleotide binding]; other site 288681004009 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 288681004010 RNA binding site [nucleotide binding]; other site 288681004011 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 288681004012 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 288681004013 homotetramer interface [polypeptide binding]; other site 288681004014 FMN binding site [chemical binding]; other site 288681004015 homodimer contacts [polypeptide binding]; other site 288681004016 putative active site [active] 288681004017 putative substrate binding site [chemical binding]; other site 288681004018 YpzI-like protein; Region: YpzI; pfam14140 288681004019 YIEGIA protein; Region: YIEGIA; pfam14045 288681004020 GTP-binding protein Der; Reviewed; Region: PRK00093 288681004021 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 288681004022 G1 box; other site 288681004023 GTP/Mg2+ binding site [chemical binding]; other site 288681004024 Switch I region; other site 288681004025 G2 box; other site 288681004026 Switch II region; other site 288681004027 G3 box; other site 288681004028 G4 box; other site 288681004029 G5 box; other site 288681004030 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 288681004031 G1 box; other site 288681004032 GTP/Mg2+ binding site [chemical binding]; other site 288681004033 Switch I region; other site 288681004034 G2 box; other site 288681004035 G3 box; other site 288681004036 Switch II region; other site 288681004037 G4 box; other site 288681004038 G5 box; other site 288681004039 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 288681004040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681004041 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 288681004042 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 288681004043 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 288681004044 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 288681004045 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 288681004046 IHF dimer interface [polypeptide binding]; other site 288681004047 IHF - DNA interface [nucleotide binding]; other site 288681004048 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 288681004049 homodecamer interface [polypeptide binding]; other site 288681004050 GTP cyclohydrolase I; Provisional; Region: PLN03044 288681004051 active site 288681004052 putative catalytic site residues [active] 288681004053 zinc binding site [ion binding]; other site 288681004054 GTP-CH-I/GFRP interaction surface; other site 288681004055 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 288681004056 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 288681004057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681004058 S-adenosylmethionine binding site [chemical binding]; other site 288681004059 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 288681004060 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288681004061 substrate binding pocket [chemical binding]; other site 288681004062 chain length determination region; other site 288681004063 substrate-Mg2+ binding site; other site 288681004064 catalytic residues [active] 288681004065 aspartate-rich region 1; other site 288681004066 active site lid residues [active] 288681004067 aspartate-rich region 2; other site 288681004068 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 288681004069 active site 288681004070 multimer interface [polypeptide binding]; other site 288681004071 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 288681004072 Tetramer interface [polypeptide binding]; other site 288681004073 active site 288681004074 FMN-binding site [chemical binding]; other site 288681004075 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 288681004076 active site 288681004077 dimer interface [polypeptide binding]; other site 288681004078 metal binding site [ion binding]; metal-binding site 288681004079 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 288681004080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681004081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004082 homodimer interface [polypeptide binding]; other site 288681004083 catalytic residue [active] 288681004084 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681004085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681004086 binding surface 288681004087 TPR motif; other site 288681004088 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 288681004089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681004090 binding surface 288681004091 TPR motif; other site 288681004092 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681004093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681004094 binding surface 288681004095 TPR motif; other site 288681004096 hypothetical protein; Provisional; Region: PRK03636 288681004097 UPF0302 domain; Region: UPF0302; pfam08864 288681004098 IDEAL domain; Region: IDEAL; cl07452 288681004099 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 288681004100 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 288681004101 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 288681004102 iron-sulfur cluster [ion binding]; other site 288681004103 [2Fe-2S] cluster binding site [ion binding]; other site 288681004104 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 288681004105 interchain domain interface [polypeptide binding]; other site 288681004106 intrachain domain interface; other site 288681004107 heme bH binding site [chemical binding]; other site 288681004108 Qi binding site; other site 288681004109 heme bL binding site [chemical binding]; other site 288681004110 Qo binding site; other site 288681004111 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 288681004112 interchain domain interface [polypeptide binding]; other site 288681004113 intrachain domain interface; other site 288681004114 Qi binding site; other site 288681004115 Qo binding site; other site 288681004116 Cytochrome c; Region: Cytochrom_C; cl11414 288681004117 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 288681004118 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 288681004119 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 288681004120 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 288681004121 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 288681004122 active site 288681004123 Fe-S cluster binding site [ion binding]; other site 288681004124 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681004125 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681004126 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681004127 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681004128 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 288681004129 homodimer interface [polypeptide binding]; other site 288681004130 metal binding site [ion binding]; metal-binding site 288681004131 dihydrodipicolinate reductase; Provisional; Region: PRK00048 288681004132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681004133 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 288681004134 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 288681004135 active site 288681004136 dimer interfaces [polypeptide binding]; other site 288681004137 catalytic residues [active] 288681004138 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 288681004139 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 288681004140 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 288681004141 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 288681004142 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 288681004143 active site 288681004144 NTP binding site [chemical binding]; other site 288681004145 metal binding triad [ion binding]; metal-binding site 288681004146 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 288681004147 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681004148 Helix-turn-helix domains; Region: HTH; cl00088 288681004149 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 288681004150 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 288681004151 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 288681004152 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 288681004153 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 288681004154 oligomerization interface [polypeptide binding]; other site 288681004155 active site 288681004156 metal binding site [ion binding]; metal-binding site 288681004157 pantoate--beta-alanine ligase; Region: panC; TIGR00018 288681004158 Pantoate-beta-alanine ligase; Region: PanC; cd00560 288681004159 active site 288681004160 ATP-binding site [chemical binding]; other site 288681004161 pantoate-binding site; other site 288681004162 HXXH motif; other site 288681004163 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 288681004164 tetramerization interface [polypeptide binding]; other site 288681004165 active site 288681004166 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 288681004167 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681004168 active site 288681004169 catalytic site [active] 288681004170 substrate binding site [chemical binding]; other site 288681004171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004173 putative Mg++ binding site [ion binding]; other site 288681004174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681004175 nucleotide binding region [chemical binding]; other site 288681004176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 288681004177 aspartate aminotransferase; Provisional; Region: PRK05764 288681004178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681004179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004180 homodimer interface [polypeptide binding]; other site 288681004181 catalytic residue [active] 288681004182 Helix-turn-helix domains; Region: HTH; cl00088 288681004183 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 288681004184 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 288681004185 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681004186 minor groove reading motif; other site 288681004187 helix-hairpin-helix signature motif; other site 288681004188 substrate binding pocket [chemical binding]; other site 288681004189 active site 288681004190 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 288681004191 Transglycosylase; Region: Transgly; cl07896 288681004192 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681004193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681004194 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681004195 Interdomain contacts; other site 288681004196 Cytokine receptor motif; other site 288681004197 Recombination protein U; Region: RecU; cl01314 288681004198 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 288681004199 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 288681004200 YppF-like protein; Region: YppF; pfam14178 288681004201 YppG-like protein; Region: YppG; pfam14179 288681004202 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 288681004203 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 288681004204 cell division protein GpsB; Provisional; Region: PRK14127 288681004205 DivIVA domain; Region: DivI1A_domain; TIGR03544 288681004206 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 288681004207 THUMP domain; Region: THUMP; cl12076 288681004208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681004209 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 288681004210 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 288681004211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004213 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 288681004214 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 288681004215 active site 288681004216 Zn binding site [ion binding]; other site 288681004217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681004218 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681004219 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 288681004220 Phosphotransferase enzyme family; Region: APH; pfam01636 288681004221 putative active site [active] 288681004222 putative substrate binding site [chemical binding]; other site 288681004223 ATP binding site [chemical binding]; other site 288681004224 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681004225 active site 288681004226 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681004227 active site 288681004228 xanthine permease; Region: pbuX; TIGR03173 288681004229 Predicted membrane protein [Function unknown]; Region: COG2311 288681004230 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681004231 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681004232 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 288681004233 Dynamin family; Region: Dynamin_N; pfam00350 288681004234 G1 box; other site 288681004235 GTP/Mg2+ binding site [chemical binding]; other site 288681004236 G2 box; other site 288681004237 Switch I region; other site 288681004238 G3 box; other site 288681004239 Switch II region; other site 288681004240 G4 box; other site 288681004241 G5 box; other site 288681004242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004243 Dynamin family; Region: Dynamin_N; pfam00350 288681004244 G1 box; other site 288681004245 GTP/Mg2+ binding site [chemical binding]; other site 288681004246 G2 box; other site 288681004247 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 288681004248 G3 box; other site 288681004249 Switch II region; other site 288681004250 GTP/Mg2+ binding site [chemical binding]; other site 288681004251 G4 box; other site 288681004252 G5 box; other site 288681004253 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 288681004254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681004255 Coenzyme A binding pocket [chemical binding]; other site 288681004256 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 288681004257 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 288681004258 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 288681004259 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 288681004260 active site residue [active] 288681004261 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 288681004262 active site residue [active] 288681004263 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 288681004264 Predicted membrane protein [Function unknown]; Region: COG3766 288681004265 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 288681004266 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 288681004267 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 288681004268 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681004269 5'-3' exonuclease; Region: 53EXOc; smart00475 288681004270 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 288681004271 active site 288681004272 metal binding site 1 [ion binding]; metal-binding site 288681004273 putative 5' ssDNA interaction site; other site 288681004274 metal binding site 3; metal-binding site 288681004275 metal binding site 2 [ion binding]; metal-binding site 288681004276 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 288681004277 putative DNA binding site [nucleotide binding]; other site 288681004278 putative metal binding site [ion binding]; other site 288681004279 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004280 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004281 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004282 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004283 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004284 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004285 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004286 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004287 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004288 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004289 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004290 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004291 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004292 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004293 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004294 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004295 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004296 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004297 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004298 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004299 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004300 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004301 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004302 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004303 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004304 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004305 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004306 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681004307 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 288681004308 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681004309 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681004310 catalytic triad [active] 288681004311 conserved cis-peptide bond; other site 288681004312 EamA-like transporter family; Region: EamA; cl01037 288681004313 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681004314 EamA-like transporter family; Region: EamA; cl01037 288681004315 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 288681004316 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681004317 active site 288681004318 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 288681004319 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 288681004320 active site 288681004321 catalytic residues [active] 288681004322 QueT transporter; Region: QueT; cl01932 288681004323 hypothetical protein; Validated; Region: PRK07708 288681004324 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 288681004325 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681004326 active site 288681004327 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 288681004328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681004329 DNA-binding site [nucleotide binding]; DNA binding site 288681004330 RNA-binding motif; other site 288681004331 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 288681004332 LysE type translocator; Region: LysE; cl00565 288681004333 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 288681004334 Protein of unknown function, DUF485; Region: DUF485; cl01231 288681004335 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681004336 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 288681004337 Na binding site [ion binding]; other site 288681004338 aminotransferase; Validated; Region: PRK07678 288681004339 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681004340 inhibitor-cofactor binding pocket; inhibition site 288681004341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004342 catalytic residue [active] 288681004343 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 288681004344 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681004345 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681004346 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681004347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681004348 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681004349 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681004350 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681004351 DNA binding residues [nucleotide binding] 288681004352 drug binding residues [chemical binding]; other site 288681004353 dimer interface [polypeptide binding]; other site 288681004354 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681004355 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 288681004356 MatE; Region: MatE; cl10513 288681004357 MatE; Region: MatE; cl10513 288681004358 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681004359 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681004360 putative active site [active] 288681004361 Tic20-like protein; Region: Tic20; pfam09685 288681004362 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 288681004363 dimer interface [polypeptide binding]; other site 288681004364 FMN binding site [chemical binding]; other site 288681004365 NADPH bind site [chemical binding]; other site 288681004366 DJ-1 family protein; Region: not_thiJ; TIGR01383 288681004367 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681004368 conserved cys residue [active] 288681004369 RNA polymerase factor sigma-70; Validated; Region: PRK06811 288681004370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681004371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004372 DNA binding residues [nucleotide binding] 288681004373 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681004374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004375 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004376 putative substrate translocation pore; other site 288681004377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681004378 dimerization interface [polypeptide binding]; other site 288681004379 putative DNA binding site [nucleotide binding]; other site 288681004380 putative Zn2+ binding site [ion binding]; other site 288681004381 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004383 putative substrate translocation pore; other site 288681004384 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681004385 active site 288681004386 metal binding site [ion binding]; metal-binding site 288681004387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681004388 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681004389 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 288681004390 Sm1 motif; other site 288681004391 D1 - D2 interaction site; other site 288681004392 D3 - B interaction site; other site 288681004393 Hfq - Hfq interaction site; other site 288681004394 RNA binding pocket [nucleotide binding]; other site 288681004395 Sm2 motif; other site 288681004396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681004397 flagellar motor protein MotP; Reviewed; Region: PRK06926 288681004398 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 288681004399 flagellar motor protein MotS; Reviewed; Region: PRK06742 288681004400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 288681004401 ligand binding site [chemical binding]; other site 288681004402 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004404 active site 288681004405 phosphorylation site [posttranslational modification] 288681004406 intermolecular recognition site; other site 288681004407 dimerization interface [polypeptide binding]; other site 288681004408 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 288681004409 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 288681004410 putative binding surface; other site 288681004411 active site 288681004412 P2 response regulator binding domain; Region: P2; pfam07194 288681004413 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 288681004414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004415 ATP binding site [chemical binding]; other site 288681004416 Mg2+ binding site [ion binding]; other site 288681004417 G-X-G motif; other site 288681004418 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 288681004419 flagellar motor switch protein; Reviewed; Region: PRK06782 288681004420 Chemotaxis phosphatase CheX; Region: CheX; cl15816 288681004421 Chemotaxis phosphatase CheX; Region: CheX; cl15816 288681004422 Chemotaxis phosphatase CheX; Region: CheX; cl15816 288681004423 Chemotaxis phosphatase CheX; Region: CheX; cl15816 288681004424 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 288681004425 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 288681004426 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 288681004427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681004428 Protein of unknown function (DUF327); Region: DUF327; cl00753 288681004429 Glutamate-cysteine ligase; Region: GshA; pfam08886 288681004430 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 288681004431 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 288681004432 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 288681004433 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004434 flagellar capping protein; Validated; Region: fliD; PRK06798 288681004435 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 288681004436 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 288681004437 Flagellar protein FliS; Region: FliS; cl00654 288681004438 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 288681004439 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 288681004440 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 288681004441 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 288681004442 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 288681004443 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 288681004444 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 288681004445 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 288681004446 FliG C-terminal domain; Region: FliG_C; pfam01706 288681004447 flagellar assembly protein H; Validated; Region: fliH; PRK06800 288681004448 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 288681004449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004450 Walker A motif; other site 288681004451 ATP binding site [chemical binding]; other site 288681004452 Walker B motif; other site 288681004453 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 288681004454 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 288681004455 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 288681004456 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 288681004457 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 288681004458 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 288681004459 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 288681004460 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 288681004461 putative CheA interaction surface; other site 288681004462 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004464 active site 288681004465 phosphorylation site [posttranslational modification] 288681004466 intermolecular recognition site; other site 288681004467 dimerization interface [polypeptide binding]; other site 288681004468 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 288681004469 flagellin; Provisional; Region: PRK12807 288681004470 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004471 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 288681004472 flagellin; Provisional; Region: PRK12808 288681004473 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004474 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 288681004475 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 288681004476 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 288681004477 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288681004478 catalytic residue [active] 288681004479 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 288681004480 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 288681004481 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 288681004482 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 288681004483 FliP family; Region: FliP; cl00593 288681004484 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 288681004485 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 288681004486 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 288681004487 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 288681004488 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 288681004489 FHIPEP family; Region: FHIPEP; pfam00771 288681004490 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 288681004491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004492 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 288681004493 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 288681004494 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 288681004495 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 288681004496 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 288681004497 Predicted transcriptional regulators [Transcription]; Region: COG1378 288681004498 Helix-turn-helix domains; Region: HTH; cl00088 288681004499 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681004500 C-terminal domain interface [polypeptide binding]; other site 288681004501 sugar binding site [chemical binding]; other site 288681004502 AzlC protein; Region: AzlC; cl00570 288681004503 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 288681004504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681004505 Helix-turn-helix domains; Region: HTH; cl00088 288681004506 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 288681004507 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681004508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004509 non-specific DNA binding site [nucleotide binding]; other site 288681004510 salt bridge; other site 288681004511 sequence-specific DNA binding site [nucleotide binding]; other site 288681004512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004513 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004514 putative substrate translocation pore; other site 288681004515 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 288681004516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681004517 Helix-turn-helix domains; Region: HTH; cl00088 288681004518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681004519 dimerization interface [polypeptide binding]; other site 288681004520 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 288681004521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004522 Walker A/P-loop; other site 288681004523 ATP binding site [chemical binding]; other site 288681004524 Q-loop/lid; other site 288681004525 ABC transporter signature motif; other site 288681004526 Walker B; other site 288681004527 D-loop; other site 288681004528 H-loop/switch region; other site 288681004529 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 288681004530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681004531 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 288681004532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004533 dimer interface [polypeptide binding]; other site 288681004534 conserved gate region; other site 288681004535 putative PBP binding loops; other site 288681004536 ABC-ATPase subunit interface; other site 288681004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004538 dimer interface [polypeptide binding]; other site 288681004539 conserved gate region; other site 288681004540 putative PBP binding loops; other site 288681004541 ABC-ATPase subunit interface; other site 288681004542 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 288681004543 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681004544 Beta-Casp domain; Region: Beta-Casp; cl12567 288681004545 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681004546 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 288681004547 Cupin domain; Region: Cupin_2; cl09118 288681004548 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681004549 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 288681004550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681004551 catalytic core [active] 288681004552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681004553 hypothetical protein; Provisional; Region: PRK09272 288681004554 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681004555 Helix-turn-helix domains; Region: HTH; cl00088 288681004556 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681004557 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681004558 active site 288681004559 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 288681004560 dimer interface [polypeptide binding]; other site 288681004561 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681004562 Ligand Binding Site [chemical binding]; other site 288681004563 Molecular Tunnel; other site 288681004564 RNA polymerase factor sigma-70; Validated; Region: PRK06811 288681004565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004566 DNA binding residues [nucleotide binding] 288681004567 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 288681004568 VPS10 domain; Region: VPS10; smart00602 288681004569 Cation efflux family; Region: Cation_efflux; cl00316 288681004570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681004571 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 288681004572 DNA-binding site [nucleotide binding]; DNA binding site 288681004573 FCD domain; Region: FCD; cl11656 288681004574 EamA-like transporter family; Region: EamA; cl01037 288681004575 EamA-like transporter family; Region: EamA; cl01037 288681004576 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681004577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004578 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004579 G4 box; other site 288681004580 G5 box; other site 288681004581 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 288681004582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681004583 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681004584 fumarate hydratase; Reviewed; Region: fumC; PRK00485 288681004585 Class II fumarases; Region: Fumarase_classII; cd01362 288681004586 active site 288681004587 tetramer interface [polypeptide binding]; other site 288681004588 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681004589 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 288681004590 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681004591 MatE; Region: MatE; cl10513 288681004592 MatE; Region: MatE; cl10513 288681004593 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 288681004594 active site pocket [active] 288681004595 oxyanion hole [active] 288681004596 catalytic triad [active] 288681004597 active site nucleophile [active] 288681004598 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 288681004599 Helix-turn-helix domains; Region: HTH; cl00088 288681004600 Peptidase family M48; Region: Peptidase_M48; cl12018 288681004601 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 288681004602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681004603 catalytic residues [active] 288681004604 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 288681004605 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681004606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004607 non-specific DNA binding site [nucleotide binding]; other site 288681004608 salt bridge; other site 288681004609 sequence-specific DNA binding site [nucleotide binding]; other site 288681004610 Cupin domain; Region: Cupin_2; cl09118 288681004611 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 288681004612 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 288681004613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681004614 catalytic residue [active] 288681004615 Protein of unknown function (DUF445); Region: DUF445; pfam04286 288681004616 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 288681004617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681004618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004619 DNA binding residues [nucleotide binding] 288681004620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681004621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004622 active site 288681004623 phosphorylation site [posttranslational modification] 288681004624 intermolecular recognition site; other site 288681004625 dimerization interface [polypeptide binding]; other site 288681004626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681004627 DNA binding residues [nucleotide binding] 288681004628 dimerization interface [polypeptide binding]; other site 288681004629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681004630 Histidine kinase; Region: HisKA_3; pfam07730 288681004631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004632 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 288681004633 Walker A/P-loop; other site 288681004634 ATP binding site [chemical binding]; other site 288681004635 Q-loop/lid; other site 288681004636 ABC transporter signature motif; other site 288681004637 Walker B; other site 288681004638 D-loop; other site 288681004639 H-loop/switch region; other site 288681004640 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 288681004641 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681004642 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681004643 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681004644 PLD-like domain; Region: PLDc_2; pfam13091 288681004645 putative active site [active] 288681004646 catalytic site [active] 288681004647 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681004648 PLD-like domain; Region: PLDc_2; pfam13091 288681004649 putative active site [active] 288681004650 catalytic site [active] 288681004651 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 288681004652 putative nucleotide binding site [chemical binding]; other site 288681004653 uridine monophosphate binding site [chemical binding]; other site 288681004654 homohexameric interface [polypeptide binding]; other site 288681004655 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681004656 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681004657 aspartate ammonia-lyase; Provisional; Region: PRK14515 288681004658 Aspartase; Region: Aspartase; cd01357 288681004659 active sites [active] 288681004660 tetramer interface [polypeptide binding]; other site 288681004661 malate dehydrogenase; Provisional; Region: PRK13529 288681004662 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681004663 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 288681004664 NAD(P) binding site [chemical binding]; other site 288681004665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681004666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004667 ATP binding site [chemical binding]; other site 288681004668 Mg2+ binding site [ion binding]; other site 288681004669 G-X-G motif; other site 288681004670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004671 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004672 active site 288681004673 phosphorylation site [posttranslational modification] 288681004674 intermolecular recognition site; other site 288681004675 dimerization interface [polypeptide binding]; other site 288681004676 YcbB domain; Region: YcbB; pfam08664 288681004677 Uncharacterized conserved protein [Function unknown]; Region: COG4715 288681004678 SWIM zinc finger; Region: SWIM; cl15408 288681004679 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 288681004680 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 288681004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681004682 ATP binding site [chemical binding]; other site 288681004683 putative Mg++ binding site [ion binding]; other site 288681004684 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 288681004685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681004686 nucleotide binding region [chemical binding]; other site 288681004687 ATP-binding site [chemical binding]; other site 288681004688 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 288681004689 dimer interface [polypeptide binding]; other site 288681004690 active site 288681004691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004692 non-specific DNA binding site [nucleotide binding]; other site 288681004693 salt bridge; other site 288681004694 sequence-specific DNA binding site [nucleotide binding]; other site 288681004695 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 288681004696 putative dimer interface [polypeptide binding]; other site 288681004697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681004698 aspartate kinase; Reviewed; Region: PRK06635 288681004699 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 288681004700 putative nucleotide binding site [chemical binding]; other site 288681004701 putative catalytic residues [active] 288681004702 putative Mg ion binding site [ion binding]; other site 288681004703 putative aspartate binding site [chemical binding]; other site 288681004704 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 288681004705 putative allosteric regulatory site; other site 288681004706 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 288681004707 putative allosteric regulatory residue; other site 288681004708 DoxX-like family; Region: DoxX_3; pfam13781 288681004709 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 288681004710 YndJ-like protein; Region: YndJ; pfam14158 288681004711 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681004712 putative active site [active] 288681004713 nucleotide binding site [chemical binding]; other site 288681004714 nudix motif; other site 288681004715 putative metal binding site [ion binding]; other site 288681004716 S-layer homology domain; Region: SLH; pfam00395 288681004717 S-layer homology domain; Region: SLH; pfam00395 288681004718 S-layer homology domain; Region: SLH; pfam00395 288681004719 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681004720 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681004721 active site 288681004722 metal binding site [ion binding]; metal-binding site 288681004723 S-layer homology domain; Region: SLH; pfam00395 288681004724 S-layer homology domain; Region: SLH; pfam00395 288681004725 S-layer homology domain; Region: SLH; pfam00395 288681004726 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 288681004727 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004729 putative substrate translocation pore; other site 288681004730 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681004731 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 288681004732 Walker A/P-loop; other site 288681004733 ATP binding site [chemical binding]; other site 288681004734 Q-loop/lid; other site 288681004735 ABC transporter signature motif; other site 288681004736 Walker B; other site 288681004737 D-loop; other site 288681004738 H-loop/switch region; other site 288681004739 TOBE domain; Region: TOBE_2; cl01440 288681004740 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 288681004741 Helix-turn-helix domains; Region: HTH; cl00088 288681004742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288681004743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681004744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004745 dimer interface [polypeptide binding]; other site 288681004746 conserved gate region; other site 288681004747 putative PBP binding loops; other site 288681004748 ABC-ATPase subunit interface; other site 288681004749 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288681004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004751 dimer interface [polypeptide binding]; other site 288681004752 conserved gate region; other site 288681004753 putative PBP binding loops; other site 288681004754 ABC-ATPase subunit interface; other site 288681004755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681004756 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681004757 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681004758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681004759 DNA-binding site [nucleotide binding]; DNA binding site 288681004760 UTRA domain; Region: UTRA; cl01230 288681004761 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 288681004762 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288681004763 dimer interface [polypeptide binding]; other site 288681004764 active site 288681004765 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 288681004766 putative active site [active] 288681004767 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 288681004768 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 288681004769 active site 288681004770 dimer interface [polypeptide binding]; other site 288681004771 hypothetical protein; Provisional; Region: PRK08185 288681004772 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681004773 intersubunit interface [polypeptide binding]; other site 288681004774 active site 288681004775 zinc binding site [ion binding]; other site 288681004776 Na+ binding site [ion binding]; other site 288681004777 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 288681004778 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288681004779 putative substrate binding site [chemical binding]; other site 288681004780 putative ATP binding site [chemical binding]; other site 288681004781 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681004782 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681004783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681004784 active site 288681004785 Helix-turn-helix domains; Region: HTH; cl00088 288681004786 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681004787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004788 putative substrate translocation pore; other site 288681004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004790 putative substrate translocation pore; other site 288681004791 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 288681004792 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681004793 dimer interface [polypeptide binding]; other site 288681004794 active site 288681004795 CoA binding pocket [chemical binding]; other site 288681004796 NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by...; Region: NTR_TIMP_like; cd03577 288681004797 Metzincin-binding interface; other site 288681004798 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 288681004799 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 288681004800 HflX GTPase family; Region: HflX; cd01878 288681004801 G1 box; other site 288681004802 GTP/Mg2+ binding site [chemical binding]; other site 288681004803 Switch I region; other site 288681004804 G2 box; other site 288681004805 G3 box; other site 288681004806 Switch II region; other site 288681004807 G4 box; other site 288681004808 G5 box; other site 288681004809 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681004810 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681004811 peptide binding site [polypeptide binding]; other site 288681004812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681004814 putative substrate translocation pore; other site 288681004815 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288681004816 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681004817 dimer interface [polypeptide binding]; other site 288681004818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004819 catalytic residue [active] 288681004820 Predicted acetyltransferase [General function prediction only]; Region: COG3981 288681004821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681004822 Coenzyme A binding pocket [chemical binding]; other site 288681004823 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 288681004824 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681004825 MatE; Region: MatE; cl10513 288681004826 MatE; Region: MatE; cl10513 288681004827 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681004828 Na2 binding site [ion binding]; other site 288681004829 putative substrate binding site 1 [chemical binding]; other site 288681004830 Na binding site 1 [ion binding]; other site 288681004831 putative substrate binding site 2 [chemical binding]; other site 288681004832 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 288681004833 NodB motif; other site 288681004834 putative active site [active] 288681004835 putative catalytic site [active] 288681004836 putative Zn binding site [ion binding]; other site 288681004837 Mor transcription activator family; Region: Mor; cl02360 288681004838 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681004839 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 288681004840 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 288681004841 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 288681004842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 288681004843 NADP binding site [chemical binding]; other site 288681004844 homodimer interface [polypeptide binding]; other site 288681004845 active site 288681004846 substrate binding site [chemical binding]; other site 288681004847 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681004848 homodimer interface [polypeptide binding]; other site 288681004849 substrate-cofactor binding pocket; other site 288681004850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004851 catalytic residue [active] 288681004852 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 288681004853 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681004854 PYR/PP interface [polypeptide binding]; other site 288681004855 dimer interface [polypeptide binding]; other site 288681004856 TPP binding site [chemical binding]; other site 288681004857 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681004858 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 288681004859 TPP-binding site [chemical binding]; other site 288681004860 dimer interface [polypeptide binding]; other site 288681004861 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 288681004862 putative valine binding site [chemical binding]; other site 288681004863 dimer interface [polypeptide binding]; other site 288681004864 ketol-acid reductoisomerase; Provisional; Region: PRK05479 288681004865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681004866 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 288681004867 Dehydratase family; Region: ILVD_EDD; cl00340 288681004868 threonine dehydratase; Validated; Region: PRK08639 288681004869 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 288681004870 tetramer interface [polypeptide binding]; other site 288681004871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004872 catalytic residue [active] 288681004873 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 288681004874 putative Ile/Val binding site [chemical binding]; other site 288681004875 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 288681004876 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 288681004877 putative active site [active] 288681004878 putative metal binding site [ion binding]; other site 288681004879 Protein of unknown function (DUF554); Region: DUF554; cl00784 288681004880 Clp protease ATP binding subunit; Region: clpC; CHL00095 288681004881 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681004882 drug efflux system protein MdtG; Provisional; Region: PRK09874 288681004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004884 putative substrate translocation pore; other site 288681004885 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 288681004886 putative active site [active] 288681004887 metal binding site [ion binding]; metal-binding site 288681004888 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 288681004889 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681004890 LytTr DNA-binding domain; Region: LytTR; cl04498 288681004891 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 288681004892 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 288681004893 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681004894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681004895 Coenzyme A binding pocket [chemical binding]; other site 288681004896 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 288681004897 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 288681004898 active site 288681004899 putative substrate binding pocket [chemical binding]; other site 288681004900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681004901 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681004902 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681004903 peptide binding site [polypeptide binding]; other site 288681004904 hypothetical protein; Provisional; Region: PRK06922 288681004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681004906 S-adenosylmethionine binding site [chemical binding]; other site 288681004907 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 288681004908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681004909 FeS/SAM binding site; other site 288681004910 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 288681004911 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681004912 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681004913 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004915 active site 288681004916 phosphorylation site [posttranslational modification] 288681004917 intermolecular recognition site; other site 288681004918 dimerization interface [polypeptide binding]; other site 288681004919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681004920 DNA binding site [nucleotide binding] 288681004921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681004922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681004923 dimerization interface [polypeptide binding]; other site 288681004924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681004925 dimer interface [polypeptide binding]; other site 288681004926 phosphorylation site [posttranslational modification] 288681004927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004928 ATP binding site [chemical binding]; other site 288681004929 Mg2+ binding site [ion binding]; other site 288681004930 G-X-G motif; other site 288681004931 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 288681004932 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681004933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681004934 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 288681004935 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 288681004936 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 288681004937 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 288681004938 active site residue [active] 288681004939 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 288681004940 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 288681004941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681004942 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 288681004943 Amino acid permease; Region: AA_permease_2; pfam13520 288681004944 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681004945 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681004946 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681004947 LysE type translocator; Region: LysE; cl00565 288681004948 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681004949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681004950 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681004951 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 288681004952 intersubunit interface [polypeptide binding]; other site 288681004953 active site 288681004954 catalytic residue [active] 288681004955 nucleoside transporter; Region: nupC; TIGR00804 288681004956 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681004957 Nucleoside recognition; Region: Gate; cl00486 288681004958 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681004959 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 288681004960 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681004961 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681004962 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 288681004963 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681004964 active site 288681004965 catalytic motif [active] 288681004966 Zn binding site [ion binding]; other site 288681004967 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 288681004968 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 288681004969 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 288681004970 VPS10 domain; Region: VPS10; smart00602 288681004971 proline aminopeptidase P II; Provisional; Region: PRK10879 288681004972 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 288681004973 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 288681004974 active site 288681004975 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 288681004976 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 288681004977 peptide synthase; Provisional; Region: PRK12467 288681004978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681004979 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004980 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681004981 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681004982 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004983 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681004984 peptide synthase; Provisional; Region: PRK12467 288681004985 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681004986 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004987 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681004988 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681004989 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004990 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681004991 peptide synthase; Provisional; Region: PRK12316 288681004992 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004993 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681004994 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681004995 Condensation domain; Region: Condensation; pfam00668 288681004996 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681004997 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004998 AMP-binding enzyme; Region: AMP-binding; cl15778 288681004999 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681005000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681005001 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681005002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005003 Walker A/P-loop; other site 288681005004 ATP binding site [chemical binding]; other site 288681005005 Q-loop/lid; other site 288681005006 ABC transporter signature motif; other site 288681005007 Walker B; other site 288681005008 D-loop; other site 288681005009 H-loop/switch region; other site 288681005010 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 288681005011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681005012 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681005013 Walker A/P-loop; other site 288681005014 ATP binding site [chemical binding]; other site 288681005015 Q-loop/lid; other site 288681005016 ABC transporter signature motif; other site 288681005017 Walker B; other site 288681005018 D-loop; other site 288681005019 H-loop/switch region; other site 288681005020 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681005021 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681005022 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681005023 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681005024 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681005025 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681005026 DNA topoisomerase III; Provisional; Region: PRK07726 288681005027 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 288681005028 active site 288681005029 putative interdomain interaction site [polypeptide binding]; other site 288681005030 putative metal-binding site [ion binding]; other site 288681005031 putative nucleotide binding site [chemical binding]; other site 288681005032 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681005033 domain I; other site 288681005034 DNA binding groove [nucleotide binding] 288681005035 phosphate binding site [ion binding]; other site 288681005036 domain II; other site 288681005037 domain III; other site 288681005038 nucleotide binding site [chemical binding]; other site 288681005039 catalytic site [active] 288681005040 domain IV; other site 288681005041 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681005042 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 288681005043 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681005044 Membrane transport protein; Region: Mem_trans; cl09117 288681005045 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681005046 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681005047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681005048 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 288681005049 dimer interface [polypeptide binding]; other site 288681005050 substrate binding site [chemical binding]; other site 288681005051 metal binding site [ion binding]; metal-binding site 288681005052 Bacterial Ig-like domain; Region: Big_5; cl01012 288681005053 Copper resistance protein D; Region: CopD; cl00563 288681005054 FixH; Region: FixH; cl01254 288681005055 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 288681005056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681005058 EamA-like transporter family; Region: EamA; cl01037 288681005059 EamA-like transporter family; Region: EamA; cl01037 288681005060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681005061 Helix-turn-helix domains; Region: HTH; cl00088 288681005062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681005063 dimerization interface [polypeptide binding]; other site 288681005064 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681005065 Helix-turn-helix domains; Region: HTH; cl00088 288681005066 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 288681005067 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 288681005068 catalytic residues [active] 288681005069 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681005070 dimer interface [polypeptide binding]; other site 288681005071 FMN binding site [chemical binding]; other site 288681005072 amidase; Provisional; Region: PRK06707 288681005073 Amidase; Region: Amidase; cl11426 288681005074 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681005075 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681005076 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681005077 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681005078 NAD binding site [chemical binding]; other site 288681005079 dimer interface [polypeptide binding]; other site 288681005080 substrate binding site [chemical binding]; other site 288681005081 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 288681005082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005083 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681005084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005085 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 288681005086 S-layer homology domain; Region: SLH; pfam00395 288681005087 S-layer homology domain; Region: SLH; pfam00395 288681005088 S-layer homology domain; Region: SLH; pfam00395 288681005089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681005090 Helix-turn-helix domains; Region: HTH; cl00088 288681005091 acyl-CoA synthetase; Validated; Region: PRK06839 288681005092 AMP-binding enzyme; Region: AMP-binding; cl15778 288681005093 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005094 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 288681005095 dimer interaction site [polypeptide binding]; other site 288681005096 substrate-binding tunnel; other site 288681005097 active site 288681005098 catalytic site [active] 288681005099 substrate binding site [chemical binding]; other site 288681005100 hypothetical protein; Validated; Region: PRK06840 288681005101 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288681005102 active site 288681005103 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 288681005104 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 288681005105 putative ligand binding site [chemical binding]; other site 288681005106 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 288681005107 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 288681005108 Walker A/P-loop; other site 288681005109 ATP binding site [chemical binding]; other site 288681005110 Q-loop/lid; other site 288681005111 ABC transporter signature motif; other site 288681005112 Walker B; other site 288681005113 D-loop; other site 288681005114 H-loop/switch region; other site 288681005115 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 288681005116 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 288681005117 Walker A/P-loop; other site 288681005118 ATP binding site [chemical binding]; other site 288681005119 Q-loop/lid; other site 288681005120 ABC transporter signature motif; other site 288681005121 Walker B; other site 288681005122 D-loop; other site 288681005123 H-loop/switch region; other site 288681005124 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 288681005125 TM-ABC transporter signature motif; other site 288681005126 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 288681005127 TM-ABC transporter signature motif; other site 288681005128 Helix-turn-helix domains; Region: HTH; cl00088 288681005129 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 288681005130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681005131 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 288681005132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681005133 Helix-turn-helix domains; Region: HTH; cl00088 288681005134 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 288681005135 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681005136 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681005137 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 288681005138 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 288681005139 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 288681005140 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 288681005141 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 288681005142 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681005143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005144 Walker A/P-loop; other site 288681005145 ATP binding site [chemical binding]; other site 288681005146 Q-loop/lid; other site 288681005147 ABC transporter signature motif; other site 288681005148 Walker B; other site 288681005149 D-loop; other site 288681005150 H-loop/switch region; other site 288681005151 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 288681005152 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681005153 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 288681005154 Walker A/P-loop; other site 288681005155 ATP binding site [chemical binding]; other site 288681005156 Q-loop/lid; other site 288681005157 ABC transporter signature motif; other site 288681005158 Walker B; other site 288681005159 D-loop; other site 288681005160 H-loop/switch region; other site 288681005161 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681005162 putative dimer interface [polypeptide binding]; other site 288681005163 catalytic triad [active] 288681005164 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681005165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681005166 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681005167 dimer interface [polypeptide binding]; other site 288681005168 FMN binding site [chemical binding]; other site 288681005169 Bacterial SH3 domain; Region: SH3_3; cl02551 288681005170 Bacterial SH3 domain; Region: SH3_3; cl02551 288681005171 Bacterial SH3 domain; Region: SH3_3; cl02551 288681005172 NlpC/P60 family; Region: NLPC_P60; cl11438 288681005173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005174 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681005175 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681005176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005177 Walker A/P-loop; other site 288681005178 ATP binding site [chemical binding]; other site 288681005179 Q-loop/lid; other site 288681005180 ABC transporter signature motif; other site 288681005181 Walker B; other site 288681005182 D-loop; other site 288681005183 H-loop/switch region; other site 288681005184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681005185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005186 active site 288681005187 phosphorylation site [posttranslational modification] 288681005188 intermolecular recognition site; other site 288681005189 dimerization interface [polypeptide binding]; other site 288681005190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681005191 DNA binding site [nucleotide binding] 288681005192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681005193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681005194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005195 dimer interface [polypeptide binding]; other site 288681005196 phosphorylation site [posttranslational modification] 288681005197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005198 ATP binding site [chemical binding]; other site 288681005199 Mg2+ binding site [ion binding]; other site 288681005200 G-X-G motif; other site 288681005201 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 288681005202 classical (c) SDRs; Region: SDR_c; cd05233 288681005203 NAD(P) binding site [chemical binding]; other site 288681005204 active site 288681005205 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288681005206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005207 S-adenosylmethionine binding site [chemical binding]; other site 288681005208 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 288681005209 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 288681005210 NodB motif; other site 288681005211 active site 288681005212 catalytic site [active] 288681005213 metal binding site [ion binding]; metal-binding site 288681005214 SdpI/YhfL protein family; Region: SdpI; pfam13630 288681005215 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681005216 nudix motif; other site 288681005217 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 288681005218 homoserine dehydrogenase; Provisional; Region: PRK06349 288681005219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005220 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681005221 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 288681005222 threonine synthase; Reviewed; Region: PRK06721 288681005223 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 288681005224 homodimer interface [polypeptide binding]; other site 288681005225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005226 catalytic residue [active] 288681005227 homoserine kinase; Provisional; Region: PRK01212 288681005228 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681005229 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681005230 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 288681005231 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681005232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681005233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005234 active site 288681005235 phosphorylation site [posttranslational modification] 288681005236 intermolecular recognition site; other site 288681005237 dimerization interface [polypeptide binding]; other site 288681005238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681005239 DNA binding site [nucleotide binding] 288681005240 sensory histidine kinase AtoS; Provisional; Region: PRK11360 288681005241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005242 dimerization interface [polypeptide binding]; other site 288681005243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005244 dimer interface [polypeptide binding]; other site 288681005245 phosphorylation site [posttranslational modification] 288681005246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005247 ATP binding site [chemical binding]; other site 288681005248 Mg2+ binding site [ion binding]; other site 288681005249 G-X-G motif; other site 288681005250 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681005251 NodB motif; other site 288681005252 active site 288681005253 catalytic site [active] 288681005254 Zn binding site [ion binding]; other site 288681005255 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 288681005256 MgtC family; Region: MgtC; pfam02308 288681005257 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 288681005258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005259 Coenzyme A binding pocket [chemical binding]; other site 288681005260 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 288681005261 IucA / IucC family; Region: IucA_IucC; pfam04183 288681005262 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288681005263 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 288681005264 IucA / IucC family; Region: IucA_IucC; pfam04183 288681005265 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288681005266 acyl-CoA synthetase; Validated; Region: PRK08308 288681005267 AMP-binding enzyme; Region: AMP-binding; cl15778 288681005268 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005269 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681005270 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 288681005271 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 288681005272 AP (apurinic/apyrimidinic) site pocket; other site 288681005273 DNA interaction; other site 288681005274 Metal-binding active site; metal-binding site 288681005275 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681005276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681005278 putative substrate translocation pore; other site 288681005279 LysE type translocator; Region: LysE; cl00565 288681005280 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681005281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681005282 DNA-binding site [nucleotide binding]; DNA binding site 288681005283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681005284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005285 homodimer interface [polypeptide binding]; other site 288681005286 catalytic residue [active] 288681005287 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 288681005288 active site 288681005289 nucleophile elbow; other site 288681005290 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 288681005291 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 288681005292 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 288681005293 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 288681005294 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681005295 nudix motif; other site 288681005296 NAD+ synthetase; Region: nadE; TIGR00552 288681005297 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 288681005298 homodimer interface [polypeptide binding]; other site 288681005299 NAD binding pocket [chemical binding]; other site 288681005300 ATP binding pocket [chemical binding]; other site 288681005301 Mg binding site [ion binding]; other site 288681005302 active-site loop [active] 288681005303 FtsX-like permease family; Region: FtsX; cl15850 288681005304 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005305 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681005306 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 288681005307 active site 288681005308 catalytic residues [active] 288681005309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681005310 dimerization interface [polypeptide binding]; other site 288681005311 putative DNA binding site [nucleotide binding]; other site 288681005312 putative Zn2+ binding site [ion binding]; other site 288681005313 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 288681005314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681005315 active site 288681005316 catalytic tetrad [active] 288681005317 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681005318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005319 putative substrate translocation pore; other site 288681005320 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 288681005321 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681005322 DinB superfamily; Region: DinB_2; pfam12867 288681005323 GTPase RsgA; Reviewed; Region: PRK01889 288681005324 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681005325 RNA binding site [nucleotide binding]; other site 288681005326 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 288681005327 GTPase/Zn-binding domain interface [polypeptide binding]; other site 288681005328 GTP/Mg2+ binding site [chemical binding]; other site 288681005329 G4 box; other site 288681005330 G5 box; other site 288681005331 G1 box; other site 288681005332 Switch I region; other site 288681005333 G2 box; other site 288681005334 G3 box; other site 288681005335 Switch II region; other site 288681005336 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681005337 Cache domain; Region: Cache_1; pfam02743 288681005338 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 288681005339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005340 dimerization interface [polypeptide binding]; other site 288681005341 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681005342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681005343 dimer interface [polypeptide binding]; other site 288681005344 putative CheW interface [polypeptide binding]; other site 288681005345 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 288681005346 Uncharacterized membrane protein [Function unknown]; Region: COG3949 288681005347 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 288681005348 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 288681005349 dimerization interface [polypeptide binding]; other site 288681005350 DPS ferroxidase diiron center [ion binding]; other site 288681005351 ion pore; other site 288681005352 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 288681005353 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681005354 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 288681005355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681005356 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 288681005357 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 288681005358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005360 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681005362 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681005363 active site 288681005364 catalytic tetrad [active] 288681005365 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681005366 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 288681005367 P-loop, Walker A motif; other site 288681005368 Base recognition motif; other site 288681005369 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 288681005370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005371 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681005372 Coenzyme A binding pocket [chemical binding]; other site 288681005373 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 288681005374 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681005375 transposase (08) fragment; frameshift mutation 288681005376 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 288681005377 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 288681005378 metal binding site [ion binding]; metal-binding site 288681005379 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 288681005380 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681005381 NAD binding site [chemical binding]; other site 288681005382 active site 288681005383 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 288681005384 active site 288681005385 FMN binding site [chemical binding]; other site 288681005386 substrate binding site [chemical binding]; other site 288681005387 homotetramer interface [polypeptide binding]; other site 288681005388 catalytic residue [active] 288681005389 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 288681005390 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 288681005391 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288681005392 DNA binding site [nucleotide binding] 288681005393 active site 288681005394 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 288681005395 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681005396 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681005397 peptide binding site [polypeptide binding]; other site 288681005398 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681005399 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681005400 active site 288681005401 metal binding site [ion binding]; metal-binding site 288681005402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005403 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681005404 catalytic core [active] 288681005405 CotH protein; Region: CotH; pfam08757 288681005406 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 288681005407 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 288681005408 nudix motif; other site 288681005409 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681005410 MatE; Region: MatE; cl10513 288681005411 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 288681005412 Predicted permease; Region: DUF318; pfam03773 288681005413 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 288681005414 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 288681005415 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681005416 PLD-like domain; Region: PLDc_2; pfam13091 288681005417 putative active site [active] 288681005418 catalytic site [active] 288681005419 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681005420 PLD-like domain; Region: PLDc_2; pfam13091 288681005421 putative active site [active] 288681005422 catalytic site [active] 288681005423 Coat F domain; Region: Coat_F; cl15836 288681005424 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681005425 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681005426 NAD binding site [chemical binding]; other site 288681005427 substrate binding site [chemical binding]; other site 288681005428 putative active site [active] 288681005429 Protein of unknown function (DUF456); Region: DUF456; cl01069 288681005430 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681005431 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681005432 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681005433 Transporter associated domain; Region: CorC_HlyC; cl08393 288681005434 FOG: CBS domain [General function prediction only]; Region: COG0517 288681005435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288681005436 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681005437 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 288681005438 dimer interface [polypeptide binding]; other site 288681005439 putative tRNA-binding site [nucleotide binding]; other site 288681005440 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681005441 DinB superfamily; Region: DinB_2; pfam12867 288681005442 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 288681005443 stage II sporulation protein P; Region: spore_II_P; TIGR02867 288681005444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005446 Coenzyme A binding pocket [chemical binding]; other site 288681005447 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005448 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681005449 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 288681005450 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 288681005451 nudix motif; other site 288681005452 amidase; Provisional; Region: PRK06828 288681005453 Amidase; Region: Amidase; cl11426 288681005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005455 putative substrate translocation pore; other site 288681005456 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 288681005457 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 288681005458 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 288681005459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681005460 catalytic core [active] 288681005461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005462 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681005463 active site 288681005464 motif I; other site 288681005465 motif II; other site 288681005466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288681005468 alanine racemase; Reviewed; Region: alr; PRK00053 288681005469 active site 288681005470 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681005471 dimer interface [polypeptide binding]; other site 288681005472 substrate binding site [chemical binding]; other site 288681005473 catalytic residues [active] 288681005474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005475 S-adenosylmethionine binding site [chemical binding]; other site 288681005476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005477 Coenzyme A binding pocket [chemical binding]; other site 288681005478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005479 Coenzyme A binding pocket [chemical binding]; other site 288681005480 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005481 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288681005482 glycosyltransferase, MGT family; Region: MGT; TIGR01426 288681005483 active site 288681005484 TDP-binding site; other site 288681005485 acceptor substrate-binding pocket; other site 288681005486 homodimer interface [polypeptide binding]; other site 288681005487 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681005488 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681005489 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681005490 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681005491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681005492 DNA-binding site [nucleotide binding]; DNA binding site 288681005493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681005494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005495 homodimer interface [polypeptide binding]; other site 288681005496 catalytic residue [active] 288681005497 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 288681005498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005499 Coenzyme A binding pocket [chemical binding]; other site 288681005500 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681005501 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 288681005502 active site 288681005503 metal binding site [ion binding]; metal-binding site 288681005504 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681005505 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681005506 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005507 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005508 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 288681005509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005511 Coenzyme A binding pocket [chemical binding]; other site 288681005512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005513 Coenzyme A binding pocket [chemical binding]; other site 288681005514 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005515 active site 288681005516 ATP binding site [chemical binding]; other site 288681005517 substrate binding site [chemical binding]; other site 288681005518 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 288681005519 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681005520 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681005521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005522 S-adenosylmethionine binding site [chemical binding]; other site 288681005523 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 288681005524 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 288681005525 Potassium binding sites [ion binding]; other site 288681005526 Cesium cation binding sites [ion binding]; other site 288681005527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005528 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681005529 ATP binding site [chemical binding]; other site 288681005530 putative Mg++ binding site [ion binding]; other site 288681005531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681005532 nucleotide binding region [chemical binding]; other site 288681005533 ATP-binding site [chemical binding]; other site 288681005534 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681005535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681005536 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288681005537 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681005538 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 288681005539 NADP binding site [chemical binding]; other site 288681005540 dimer interface [polypeptide binding]; other site 288681005541 RNA polymerase sigma factor; Provisional; Region: PRK12543 288681005542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681005543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681005544 DNA binding residues [nucleotide binding] 288681005545 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 288681005546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681005547 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 288681005548 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 288681005549 catalytic residues [active] 288681005550 dimer interface [polypeptide binding]; other site 288681005551 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 288681005552 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 288681005553 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681005554 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681005555 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681005556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681005557 Walker A motif; other site 288681005558 ATP binding site [chemical binding]; other site 288681005559 Walker B motif; other site 288681005560 arginine finger; other site 288681005561 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 288681005562 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 288681005563 [4Fe-4S] binding site [ion binding]; other site 288681005564 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005566 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005567 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 288681005568 molybdopterin cofactor binding site; other site 288681005569 nitrate reductase, beta subunit; Region: narH; TIGR01660 288681005570 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 288681005571 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 288681005572 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 288681005573 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681005574 ligand binding site [chemical binding]; other site 288681005575 flexible hinge region; other site 288681005576 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 288681005577 putative switch regulator; other site 288681005578 non-specific DNA interactions [nucleotide binding]; other site 288681005579 DNA binding site [nucleotide binding] 288681005580 sequence specific DNA binding site [nucleotide binding]; other site 288681005581 putative cAMP binding site [chemical binding]; other site 288681005582 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 288681005583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681005584 FeS/SAM binding site; other site 288681005585 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681005586 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681005587 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681005588 ATP binding site [chemical binding]; other site 288681005589 substrate interface [chemical binding]; other site 288681005590 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681005591 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681005592 dimer interface [polypeptide binding]; other site 288681005593 putative functional site; other site 288681005594 putative MPT binding site; other site 288681005595 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681005596 MoaE homodimer interface [polypeptide binding]; other site 288681005597 MoaD interaction [polypeptide binding]; other site 288681005598 active site residues [active] 288681005599 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681005600 MoaE interaction surface [polypeptide binding]; other site 288681005601 MoeB interaction surface [polypeptide binding]; other site 288681005602 thiocarboxylated glycine; other site 288681005603 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 288681005604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005605 putative substrate translocation pore; other site 288681005606 Membrane transport protein; Region: Mem_trans; cl09117 288681005607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005608 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 288681005609 putative active site [active] 288681005610 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 288681005611 putative active site [active] 288681005612 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 288681005613 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 288681005614 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 288681005615 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 288681005616 [2Fe-2S] cluster binding site [ion binding]; other site 288681005617 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 288681005618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681005619 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 288681005620 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 288681005621 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681005622 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 288681005623 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 288681005624 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 288681005625 Excalibur calcium-binding domain; Region: Excalibur; cl05460 288681005626 N-acetyltransferase; Region: Acetyltransf_2; cl00949 288681005627 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 288681005628 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681005629 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 288681005630 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 288681005631 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 288681005632 active site flap/lid [active] 288681005633 nucleophilic elbow; other site 288681005634 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681005635 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 288681005636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681005637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681005638 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681005639 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681005640 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681005641 ABC transporter; Region: ABC_tran_2; pfam12848 288681005642 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681005643 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 288681005644 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 288681005645 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288681005646 dimer interface [polypeptide binding]; other site 288681005647 ssDNA binding site [nucleotide binding]; other site 288681005648 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681005649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681005650 Helix-turn-helix domains; Region: HTH; cl00088 288681005651 hypothetical protein; Provisional; Region: PRK06753 288681005652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681005653 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 288681005654 Virulence factor; Region: Virulence_fact; pfam13769 288681005655 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 288681005656 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 288681005657 Protein of unknown function, DUF393; Region: DUF393; cl01136 288681005658 Disulphide isomerase; Region: Disulph_isomer; cl05813 288681005659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681005660 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 288681005661 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 288681005662 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 288681005663 active site 288681005664 HIGH motif; other site 288681005665 KMSK motif region; other site 288681005666 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 288681005667 tRNA binding surface [nucleotide binding]; other site 288681005668 anticodon binding site; other site 288681005669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681005670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681005671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681005672 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681005673 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 288681005674 putative active site [active] 288681005675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681005676 binding surface 288681005677 TPR motif; other site 288681005678 TPR repeat; Region: TPR_11; pfam13414 288681005679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005680 binding surface 288681005681 TPR motif; other site 288681005682 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681005683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005684 binding surface 288681005685 TPR motif; other site 288681005686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005687 binding surface 288681005688 TPR motif; other site 288681005689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005690 binding surface 288681005691 TPR motif; other site 288681005692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005693 binding surface 288681005694 TPR motif; other site 288681005695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681005696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005697 binding surface 288681005698 TPR motif; other site 288681005699 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 288681005700 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681005701 HIGH motif; other site 288681005702 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681005703 active site 288681005704 KMSKS motif; other site 288681005705 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 288681005706 tRNA binding surface [nucleotide binding]; other site 288681005707 anticodon binding site; other site 288681005708 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 288681005709 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681005710 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681005711 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 288681005712 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 288681005713 Zn binding site [ion binding]; other site 288681005714 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 288681005715 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681005716 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681005717 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681005718 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 288681005719 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 288681005720 Dimer interface [polypeptide binding]; other site 288681005721 anticodon binding site; other site 288681005722 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 288681005723 homodimer interface [polypeptide binding]; other site 288681005724 motif 1; other site 288681005725 motif 2; other site 288681005726 active site 288681005727 motif 3; other site 288681005728 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 288681005729 metal ion-dependent adhesion site (MIDAS); other site 288681005730 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 288681005731 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 288681005732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005734 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005735 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681005736 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005737 active site 288681005738 ATP binding site [chemical binding]; other site 288681005739 substrate binding site [chemical binding]; other site 288681005740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005741 binding surface 288681005742 TPR repeat; Region: TPR_11; pfam13414 288681005743 TPR motif; other site 288681005744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005745 binding surface 288681005746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681005747 TPR motif; other site 288681005748 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681005749 Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: TyrS; COG0162 288681005750 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 288681005751 catalytic residues [active] 288681005752 catalytic nucleophile [active] 288681005753 Recombinase; Region: Recombinase; pfam07508 288681005754 Transposase; Region: DEDD_Tnp_IS110; pfam01548 288681005755 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 288681005756 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 288681005757 Protein of unknown function, DUF600; Region: DUF600; cl04640 288681005758 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681005759 Na2 binding site [ion binding]; other site 288681005760 putative substrate binding site 1 [chemical binding]; other site 288681005761 Na binding site 1 [ion binding]; other site 288681005762 putative substrate binding site 2 [chemical binding]; other site 288681005763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005764 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 288681005765 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 288681005766 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681005767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005768 motif II; other site 288681005769 Citrate transporter; Region: CitMHS; pfam03600 288681005770 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 288681005771 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 288681005772 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 288681005773 active site 288681005774 NAD binding site [chemical binding]; other site 288681005775 metal binding site [ion binding]; metal-binding site 288681005776 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288681005777 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 288681005778 homodimer interaction site [polypeptide binding]; other site 288681005779 cofactor binding site; other site 288681005780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005782 Coenzyme A binding pocket [chemical binding]; other site 288681005783 hypothetical protein; Validated; Region: PRK06769 288681005784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005785 active site 288681005786 motif I; other site 288681005787 motif II; other site 288681005788 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681005789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005790 Coenzyme A binding pocket [chemical binding]; other site 288681005791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681005792 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681005793 Walker A/P-loop; other site 288681005794 ATP binding site [chemical binding]; other site 288681005795 Q-loop/lid; other site 288681005796 ABC transporter signature motif; other site 288681005797 Walker B; other site 288681005798 D-loop; other site 288681005799 H-loop/switch region; other site 288681005800 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 288681005801 YpjP-like protein; Region: YpjP; pfam14005 288681005802 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681005803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005804 motif II; other site 288681005805 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681005806 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681005807 active site 288681005808 metal binding site [ion binding]; metal-binding site 288681005809 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 288681005810 Phosphotransferase enzyme family; Region: APH; pfam01636 288681005811 active site 288681005812 substrate binding site [chemical binding]; other site 288681005813 ATP binding site [chemical binding]; other site 288681005814 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 288681005815 Active site serine [active] 288681005816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681005817 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 288681005818 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 288681005819 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 288681005820 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 288681005821 dimerization interface [polypeptide binding]; other site 288681005822 active site 288681005823 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 288681005824 folate binding site [chemical binding]; other site 288681005825 NADP+ binding site [chemical binding]; other site 288681005826 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 288681005827 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681005828 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681005829 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681005830 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681005831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288681005832 putative acyl-acceptor binding pocket; other site 288681005833 Haemolysin-III related; Region: HlyIII; cl03831 288681005834 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 288681005835 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 288681005836 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 288681005837 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 288681005838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681005839 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 288681005840 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 288681005841 Cu(I) binding site [ion binding]; other site 288681005842 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681005843 putative dimer interface [polypeptide binding]; other site 288681005844 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 288681005845 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681005846 active site 288681005847 dimer interface [polypeptide binding]; other site 288681005848 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681005849 Ligand Binding Site [chemical binding]; other site 288681005850 Molecular Tunnel; other site 288681005851 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005852 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681005853 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 288681005854 siderophore binding site; other site 288681005855 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681005856 homodimer interface [polypeptide binding]; other site 288681005857 substrate-cofactor binding pocket; other site 288681005858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005859 catalytic residue [active] 288681005860 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 288681005861 FMN binding site [chemical binding]; other site 288681005862 dimer interface [polypeptide binding]; other site 288681005863 Isochorismatase family; Region: Isochorismatase; pfam00857 288681005864 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 288681005865 catalytic triad [active] 288681005866 conserved cis-peptide bond; other site 288681005867 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681005868 nudix motif; other site 288681005869 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 288681005870 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 288681005871 putative dimer interface [polypeptide binding]; other site 288681005872 Mechanosensitive ion channel; Region: MS_channel; pfam00924 288681005873 GAF domain; Region: GAF_2; pfam13185 288681005874 GAF domain; Region: GAF; cl15785 288681005875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 288681005876 Histidine kinase; Region: HisKA_3; pfam07730 288681005877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005878 ATP binding site [chemical binding]; other site 288681005879 Mg2+ binding site [ion binding]; other site 288681005880 G-X-G motif; other site 288681005881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005883 active site 288681005884 phosphorylation site [posttranslational modification] 288681005885 intermolecular recognition site; other site 288681005886 dimerization interface [polypeptide binding]; other site 288681005887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681005888 DNA binding residues [nucleotide binding] 288681005889 dimerization interface [polypeptide binding]; other site 288681005890 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288681005891 putative active site [active] 288681005892 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 288681005893 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 288681005894 NAD binding site [chemical binding]; other site 288681005895 substrate binding site [chemical binding]; other site 288681005896 catalytic Zn binding site [ion binding]; other site 288681005897 tetramer interface [polypeptide binding]; other site 288681005898 structural Zn binding site [ion binding]; other site 288681005899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681005900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681005901 dimer interface [polypeptide binding]; other site 288681005902 conserved gate region; other site 288681005903 ABC-ATPase subunit interface; other site 288681005904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681005905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681005906 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 288681005907 Erythromycin esterase; Region: Erythro_esteras; pfam05139 288681005908 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 288681005909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681005910 active site 288681005911 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681005912 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288681005913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005914 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681005915 putative substrate translocation pore; other site 288681005916 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681005917 putative active site [active] 288681005918 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 288681005919 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 288681005920 Walker A/P-loop; other site 288681005921 ATP binding site [chemical binding]; other site 288681005922 Q-loop/lid; other site 288681005923 ABC transporter signature motif; other site 288681005924 Walker B; other site 288681005925 D-loop; other site 288681005926 H-loop/switch region; other site 288681005927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681005928 dimer interface [polypeptide binding]; other site 288681005929 conserved gate region; other site 288681005930 ABC-ATPase subunit interface; other site 288681005931 NMT1-like family; Region: NMT1_2; cl15260 288681005932 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 288681005933 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 288681005934 Spore germination protein; Region: Spore_permease; cl15802 288681005935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681005936 Protein of unknown function (DUF524); Region: DUF524; pfam04411 288681005937 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 288681005938 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681005939 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681005940 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681005941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681005942 Transporter associated domain; Region: CorC_HlyC; cl08393 288681005943 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 288681005944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681005945 NAD(P) binding site [chemical binding]; other site 288681005946 catalytic residues [active] 288681005947 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 288681005948 Histidine kinase N terminal; Region: HisK_N; pfam09385 288681005949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005950 dimer interface [polypeptide binding]; other site 288681005951 phosphorylation site [posttranslational modification] 288681005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005953 ATP binding site [chemical binding]; other site 288681005954 Mg2+ binding site [ion binding]; other site 288681005955 G-X-G motif; other site 288681005956 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 288681005957 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 288681005958 hypothetical protein; Provisional; Region: PRK06917 288681005959 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681005960 inhibitor-cofactor binding pocket; inhibition site 288681005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005962 catalytic residue [active] 288681005963 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681005964 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681005965 acetylornithine deacetylase; Validated; Region: PRK06915 288681005966 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 288681005967 metal binding site [ion binding]; metal-binding site 288681005968 dimer interface [polypeptide binding]; other site 288681005969 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 288681005970 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681005971 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681005972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681005973 Walker A motif; other site 288681005974 ATP binding site [chemical binding]; other site 288681005975 Walker B motif; other site 288681005976 arginine finger; other site 288681005977 Helix-turn-helix domains; Region: HTH; cl00088 288681005978 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 288681005979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681005980 FeS/SAM binding site; other site 288681005981 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 288681005982 YokU-like protein; Region: YokU; cl15819 288681005983 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 288681005984 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 288681005985 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 288681005986 YozD-like protein; Region: YozD; pfam14162 288681005987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288681005988 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288681005989 active site 288681005990 ATP binding site [chemical binding]; other site 288681005991 substrate binding site [chemical binding]; other site 288681005992 activation loop (A-loop); other site 288681005993 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 288681005994 SpoOM protein; Region: Spo0M; pfam07070 288681005995 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 288681005996 active site 288681005997 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 288681005998 Cation efflux family; Region: Cation_efflux; cl00316 288681005999 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681006000 catalytic residues [active] 288681006001 CHRD domain; Region: CHRD; cl06473 288681006002 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 288681006003 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 288681006004 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 288681006005 PPIC-type PPIASE domain; Region: Rotamase; cl08278 288681006006 YolD-like protein; Region: YolD; pfam08863 288681006007 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681006008 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 288681006009 Transglycosylase; Region: Transgly; cl07896 288681006010 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681006011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681006014 putative substrate translocation pore; other site 288681006015 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 288681006016 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 288681006017 dimer interface [polypeptide binding]; other site 288681006018 Citrate synthase; Region: Citrate_synt; pfam00285 288681006019 active site 288681006020 coenzyme A binding site [chemical binding]; other site 288681006021 citrylCoA binding site [chemical binding]; other site 288681006022 oxalacetate/citrate binding site [chemical binding]; other site 288681006023 catalytic triad [active] 288681006024 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 288681006025 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 288681006026 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681006027 tetramer interface [polypeptide binding]; other site 288681006028 active site 288681006029 Mg2+/Mn2+ binding site [ion binding]; other site 288681006030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681006031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681006032 active site 288681006033 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 288681006034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006035 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681006036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681006037 tetrameric interface [polypeptide binding]; other site 288681006038 NAD binding site [chemical binding]; other site 288681006039 catalytic residues [active] 288681006040 LysE type translocator; Region: LysE; cl00565 288681006041 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 288681006042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681006043 substrate binding site [chemical binding]; other site 288681006044 oxyanion hole (OAH) forming residues; other site 288681006045 trimer interface [polypeptide binding]; other site 288681006046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 288681006047 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 288681006048 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 288681006049 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 288681006050 active site 288681006051 metal binding site [ion binding]; metal-binding site 288681006052 DNA binding site [nucleotide binding] 288681006053 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 288681006054 exonuclease SbcC; Region: sbcc; TIGR00618 288681006055 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 288681006056 Walker A/P-loop; other site 288681006057 ATP binding site [chemical binding]; other site 288681006058 Q-loop/lid; other site 288681006059 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 288681006060 ABC transporter signature motif; other site 288681006061 Walker B; other site 288681006062 D-loop; other site 288681006063 H-loop/switch region; other site 288681006064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681006065 dimerization interface [polypeptide binding]; other site 288681006066 putative DNA binding site [nucleotide binding]; other site 288681006067 putative Zn2+ binding site [ion binding]; other site 288681006068 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 288681006069 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 288681006070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006071 putative substrate translocation pore; other site 288681006072 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681006073 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 288681006074 putative NAD(P) binding site [chemical binding]; other site 288681006075 active site 288681006076 isochorismate synthase DhbC; Validated; Region: PRK06923 288681006077 chorismate binding enzyme; Region: Chorismate_bind; cl10555 288681006078 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 288681006079 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006080 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006081 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 288681006082 hydrophobic substrate binding pocket; other site 288681006083 Isochorismatase family; Region: Isochorismatase; pfam00857 288681006084 active site 288681006085 conserved cis-peptide bond; other site 288681006086 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681006087 peptide synthase; Provisional; Region: PRK12316 288681006088 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006089 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006090 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681006091 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 288681006092 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681006093 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006094 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006095 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681006096 MbtH-like protein; Region: MbtH; cl01279 288681006097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681006099 putative substrate translocation pore; other site 288681006100 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 288681006101 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 288681006102 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 288681006103 IHF dimer interface [polypeptide binding]; other site 288681006104 IHF - DNA interface [nucleotide binding]; other site 288681006105 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 288681006106 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681006107 DinB superfamily; Region: DinB_2; pfam12867 288681006108 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681006109 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 288681006110 active site 288681006111 catalytic triad [active] 288681006112 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681006113 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681006114 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681006115 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681006116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681006117 RNA binding surface [nucleotide binding]; other site 288681006118 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 288681006119 probable active site [active] 288681006120 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 288681006121 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 288681006122 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 288681006123 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288681006124 active site 288681006125 dimer interface [polypeptide binding]; other site 288681006126 motif 1; other site 288681006127 motif 2; other site 288681006128 motif 3; other site 288681006129 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 288681006130 anticodon binding site; other site 288681006131 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006132 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681006133 Walker A/P-loop; other site 288681006134 ATP binding site [chemical binding]; other site 288681006135 Q-loop/lid; other site 288681006136 ABC transporter signature motif; other site 288681006137 Walker B; other site 288681006138 D-loop; other site 288681006139 H-loop/switch region; other site 288681006140 FtsX-like permease family; Region: FtsX; cl15850 288681006141 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681006142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681006143 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006144 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681006145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681006146 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681006147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681006148 dimer interface [polypeptide binding]; other site 288681006149 conserved gate region; other site 288681006150 ABC-ATPase subunit interface; other site 288681006151 pyruvate oxidase; Provisional; Region: PRK08611 288681006152 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 288681006153 PYR/PP interface [polypeptide binding]; other site 288681006154 dimer interface [polypeptide binding]; other site 288681006155 tetramer interface [polypeptide binding]; other site 288681006156 TPP binding site [chemical binding]; other site 288681006157 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681006158 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 288681006159 TPP-binding site [chemical binding]; other site 288681006160 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 288681006161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006162 S-adenosylmethionine binding site [chemical binding]; other site 288681006163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681006164 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 288681006165 active site 288681006166 dimerization interface [polypeptide binding]; other site 288681006167 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 288681006168 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681006170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006171 Helix-turn-helix domains; Region: HTH; cl00088 288681006172 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 288681006173 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 288681006174 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 288681006175 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 288681006176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006177 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006178 Coenzyme A binding pocket [chemical binding]; other site 288681006179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681006180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006181 Coenzyme A binding pocket [chemical binding]; other site 288681006182 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681006183 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681006184 putative acetyltransferase YhhY; Provisional; Region: PRK10140 288681006185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006186 Coenzyme A binding pocket [chemical binding]; other site 288681006187 EamA-like transporter family; Region: EamA; cl01037 288681006188 EamA-like transporter family; Region: EamA; cl01037 288681006189 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681006190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006191 non-specific DNA binding site [nucleotide binding]; other site 288681006192 salt bridge; other site 288681006193 sequence-specific DNA binding site [nucleotide binding]; other site 288681006194 Cupin domain; Region: Cupin_2; cl09118 288681006195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681006196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681006197 protoporphyrinogen oxidase; Provisional; Region: PRK12416 288681006198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006199 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681006200 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006201 Cold-inducible protein YdjO; Region: YdjO; pfam14169 288681006202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681006203 DNA-binding site [nucleotide binding]; DNA binding site 288681006204 RNA-binding motif; other site 288681006205 CAAX protease self-immunity; Region: Abi; cl00558 288681006206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681006207 AAA domain; Region: AAA_18; pfam13238 288681006208 Arginase family; Region: Arginase; cl00306 288681006209 hypothetical protein; Provisional; Region: PRK06770 288681006210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681006211 Helix-turn-helix domains; Region: HTH; cl00088 288681006212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006213 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681006214 putative substrate translocation pore; other site 288681006215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681006216 Helix-turn-helix domains; Region: HTH; cl00088 288681006217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681006218 dimerization interface [polypeptide binding]; other site 288681006219 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 288681006220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006221 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 288681006222 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 288681006223 active site 288681006224 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 288681006225 Helix-turn-helix domains; Region: HTH; cl00088 288681006226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681006227 dimerization interface [polypeptide binding]; other site 288681006228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 288681006229 MOSC domain; Region: MOSC; pfam03473 288681006230 3-alpha domain; Region: 3-alpha; pfam03475 288681006231 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006232 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 288681006233 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 288681006234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681006235 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681006236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681006237 Walker A/P-loop; other site 288681006238 ATP binding site [chemical binding]; other site 288681006239 Q-loop/lid; other site 288681006240 ABC transporter signature motif; other site 288681006241 Walker B; other site 288681006242 D-loop; other site 288681006243 H-loop/switch region; other site 288681006244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681006245 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681006246 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 288681006247 Walker A/P-loop; other site 288681006248 ATP binding site [chemical binding]; other site 288681006249 Q-loop/lid; other site 288681006250 ABC transporter signature motif; other site 288681006251 Walker B; other site 288681006252 D-loop; other site 288681006253 H-loop/switch region; other site 288681006254 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681006255 active site 288681006256 metal binding site [ion binding]; metal-binding site 288681006257 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 288681006258 LysE type translocator; Region: LysE; cl00565 288681006259 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681006260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006261 non-specific DNA binding site [nucleotide binding]; other site 288681006262 salt bridge; other site 288681006263 sequence-specific DNA binding site [nucleotide binding]; other site 288681006264 Cupin domain; Region: Cupin_2; cl09118 288681006265 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 288681006266 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 288681006267 BclB C-terminal domain; Region: exospore_TM; TIGR03721 288681006268 Cupin domain; Region: Cupin_2; cl09118 288681006269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681006270 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 288681006271 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 288681006272 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 288681006273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006274 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 288681006275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681006276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681006277 O-methyltransferase; Region: Methyltransf_3; pfam01596 288681006278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006279 S-adenosylmethionine binding site [chemical binding]; other site 288681006280 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 288681006281 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 288681006282 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 288681006283 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681006284 active site 288681006285 P-loop; other site 288681006286 phosphorylation site [posttranslational modification] 288681006287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681006288 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681006289 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 288681006290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681006291 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681006292 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 288681006293 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006294 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 288681006295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681006296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681006297 catalytic residue [active] 288681006298 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 288681006299 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 288681006300 tetramer interface [polypeptide binding]; other site 288681006301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006302 catalytic residue [active] 288681006303 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 288681006304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681006305 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 288681006306 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681006307 ATP binding site [chemical binding]; other site 288681006308 Mg++ binding site [ion binding]; other site 288681006309 motif III; other site 288681006310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681006311 nucleotide binding region [chemical binding]; other site 288681006312 ATP-binding site [chemical binding]; other site 288681006313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006314 Helix-turn-helix domains; Region: HTH; cl00088 288681006315 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681006317 FtsX-like permease family; Region: FtsX; cl15850 288681006318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006319 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681006320 Walker A/P-loop; other site 288681006321 ATP binding site [chemical binding]; other site 288681006322 Q-loop/lid; other site 288681006323 ABC transporter signature motif; other site 288681006324 Walker B; other site 288681006325 D-loop; other site 288681006326 H-loop/switch region; other site 288681006327 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681006328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006329 S-adenosylmethionine binding site [chemical binding]; other site 288681006330 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 288681006331 dimer interface [polypeptide binding]; other site 288681006332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681006333 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 288681006334 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 288681006335 dimer interface [polypeptide binding]; other site 288681006336 PYR/PP interface [polypeptide binding]; other site 288681006337 TPP binding site [chemical binding]; other site 288681006338 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681006339 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 288681006340 TPP-binding site [chemical binding]; other site 288681006341 dimer interface [polypeptide binding]; other site 288681006342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681006343 Helix-turn-helix domains; Region: HTH; cl00088 288681006344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681006345 catalytic core [active] 288681006346 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 288681006347 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 288681006348 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 288681006349 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 288681006350 metal binding site [ion binding]; metal-binding site 288681006351 dimer interface [polypeptide binding]; other site 288681006352 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 288681006353 active site 288681006354 catalytic triad [active] 288681006355 oxyanion hole [active] 288681006356 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 288681006357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681006358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681006359 DNA binding residues [nucleotide binding] 288681006360 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681006361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006363 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681006364 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006367 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681006368 active site 288681006369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681006370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681006371 DNA binding site [nucleotide binding] 288681006372 domain linker motif; other site 288681006373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681006374 dimerization interface [polypeptide binding]; other site 288681006375 ligand binding site [chemical binding]; other site 288681006376 polyol permease family; Region: 2A0118; TIGR00897 288681006377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006378 putative substrate translocation pore; other site 288681006379 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681006380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006381 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681006382 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681006383 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681006384 substrate binding site [chemical binding]; other site 288681006385 ATP binding site [chemical binding]; other site 288681006386 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681006387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681006388 tetrameric interface [polypeptide binding]; other site 288681006389 NAD binding site [chemical binding]; other site 288681006390 catalytic residues [active] 288681006391 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 288681006392 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681006393 PYR/PP interface [polypeptide binding]; other site 288681006394 dimer interface [polypeptide binding]; other site 288681006395 TPP binding site [chemical binding]; other site 288681006396 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681006397 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 288681006398 TPP-binding site; other site 288681006399 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681006400 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 288681006401 Metal-binding active site; metal-binding site 288681006402 hypothetical protein; Provisional; Region: PRK08185 288681006403 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681006404 intersubunit interface [polypeptide binding]; other site 288681006405 active site 288681006406 zinc binding site [ion binding]; other site 288681006407 Na+ binding site [ion binding]; other site 288681006408 KduI/IolB family; Region: KduI; cl01508 288681006409 DinB superfamily; Region: DinB_2; pfam12867 288681006410 DinB superfamily; Region: DinB_2; pfam12867 288681006411 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681006412 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681006413 active site 288681006414 metal binding site [ion binding]; metal-binding site 288681006415 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681006416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681006417 TPR motif; other site 288681006418 binding surface 288681006419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006420 non-specific DNA binding site [nucleotide binding]; other site 288681006421 salt bridge; other site 288681006422 sequence-specific DNA binding site [nucleotide binding]; other site 288681006423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681006424 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681006425 Probable transposase; Region: OrfB_IS605; pfam01385 288681006426 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681006427 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681006428 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 288681006429 S-layer homology domain; Region: SLH; pfam00395 288681006430 S-layer homology domain; Region: SLH; pfam00395 288681006431 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681006432 active site 288681006433 metal binding site [ion binding]; metal-binding site 288681006434 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 288681006435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006436 Helix-turn-helix domains; Region: HTH; cl00088 288681006437 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681006438 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681006439 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681006440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681006441 PAS fold; Region: PAS_4; pfam08448 288681006442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681006443 metal binding site [ion binding]; metal-binding site 288681006444 active site 288681006445 I-site; other site 288681006446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681006447 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681006448 Cache domain; Region: Cache_1; pfam02743 288681006449 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681006450 dimerization interface [polypeptide binding]; other site 288681006451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681006452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681006453 dimer interface [polypeptide binding]; other site 288681006454 putative CheW interface [polypeptide binding]; other site 288681006455 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 288681006456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681006458 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681006459 active site residue [active] 288681006460 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681006461 active site residue [active] 288681006462 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681006463 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681006464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681006465 Walker A/P-loop; other site 288681006466 ATP binding site [chemical binding]; other site 288681006467 Q-loop/lid; other site 288681006468 ABC transporter signature motif; other site 288681006469 Walker B; other site 288681006470 D-loop; other site 288681006471 H-loop/switch region; other site 288681006472 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681006473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006474 Helix-turn-helix domains; Region: HTH; cl00088 288681006475 Protein of unknown function (DUF523); Region: DUF523; cl00733 288681006476 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 288681006477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681006478 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681006479 FAD binding site [chemical binding]; other site 288681006480 homotetramer interface [polypeptide binding]; other site 288681006481 substrate binding pocket [chemical binding]; other site 288681006482 catalytic base [active] 288681006483 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 288681006484 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681006485 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681006486 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 288681006487 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681006488 carboxyltransferase (CT) interaction site; other site 288681006489 biotinylation site [posttranslational modification]; other site 288681006490 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 288681006491 active site 288681006492 catalytic residues [active] 288681006493 metal binding site [ion binding]; metal-binding site 288681006494 enoyl-CoA hydratase; Provisional; Region: PRK07657 288681006495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681006496 substrate binding site [chemical binding]; other site 288681006497 oxyanion hole (OAH) forming residues; other site 288681006498 trimer interface [polypeptide binding]; other site 288681006499 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 288681006500 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 288681006501 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 288681006502 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 288681006503 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 288681006504 AMP-binding enzyme; Region: AMP-binding; cl15778 288681006505 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006506 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681006507 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006508 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 288681006509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681006510 active site 288681006511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681006512 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681006513 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681006514 DinB superfamily; Region: DinB_2; pfam12867 288681006515 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681006516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681006518 dimer interface [polypeptide binding]; other site 288681006519 phosphorylation site [posttranslational modification] 288681006520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006521 ATP binding site [chemical binding]; other site 288681006522 Mg2+ binding site [ion binding]; other site 288681006523 G-X-G motif; other site 288681006524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681006525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681006526 active site 288681006527 phosphorylation site [posttranslational modification] 288681006528 intermolecular recognition site; other site 288681006529 dimerization interface [polypeptide binding]; other site 288681006530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681006531 DNA binding site [nucleotide binding] 288681006532 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 288681006533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681006534 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288681006535 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681006536 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681006537 NAD binding site [chemical binding]; other site 288681006538 substrate binding site [chemical binding]; other site 288681006539 putative active site [active] 288681006540 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681006541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006542 Coenzyme A binding pocket [chemical binding]; other site 288681006543 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006544 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681006545 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681006546 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681006547 active site 288681006548 Zn binding site [ion binding]; other site 288681006549 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 288681006550 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 288681006551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681006552 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 288681006553 putative hydrophobic ligand binding site [chemical binding]; other site 288681006554 Helix-turn-helix domains; Region: HTH; cl00088 288681006555 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006556 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681006557 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681006558 DNA binding residues [nucleotide binding] 288681006559 drug binding residues [chemical binding]; other site 288681006560 dimer interface [polypeptide binding]; other site 288681006561 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681006562 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006564 putative substrate translocation pore; other site 288681006565 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681006566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006567 S-adenosylmethionine binding site [chemical binding]; other site 288681006568 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681006569 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681006570 metal binding site [ion binding]; metal-binding site 288681006571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006572 Phosphotransferase enzyme family; Region: APH; pfam01636 288681006573 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006574 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006575 active site 288681006576 ATP binding site [chemical binding]; other site 288681006577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 288681006578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681006579 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681006580 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681006581 active site 288681006582 Zn binding site [ion binding]; other site 288681006583 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 288681006584 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006586 DNA-binding site [nucleotide binding]; DNA binding site 288681006587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006589 homodimer interface [polypeptide binding]; other site 288681006590 catalytic residue [active] 288681006591 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681006592 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288681006593 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 288681006594 putative NAD(P) binding site [chemical binding]; other site 288681006595 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681006596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006597 S-adenosylmethionine binding site [chemical binding]; other site 288681006598 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681006599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681006600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681006601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006602 S-adenosylmethionine binding site [chemical binding]; other site 288681006603 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 288681006604 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 288681006605 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 288681006606 active site 288681006607 HIGH motif; other site 288681006608 KMSKS motif; other site 288681006609 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681006610 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 288681006611 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681006612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681006613 active site 288681006614 phosphorylation site [posttranslational modification] 288681006615 intermolecular recognition site; other site 288681006616 dimerization interface [polypeptide binding]; other site 288681006617 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681006618 DNA binding site [nucleotide binding] 288681006619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681006620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 288681006621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006622 ATP binding site [chemical binding]; other site 288681006623 Mg2+ binding site [ion binding]; other site 288681006624 G-X-G motif; other site 288681006625 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681006626 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681006627 ABC transporter; Region: ABC_tran_2; pfam12848 288681006628 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681006629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681006630 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006631 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 288681006632 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006633 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681006634 Walker A/P-loop; other site 288681006635 ATP binding site [chemical binding]; other site 288681006636 Q-loop/lid; other site 288681006637 ABC transporter signature motif; other site 288681006638 Walker B; other site 288681006639 D-loop; other site 288681006640 H-loop/switch region; other site 288681006641 FtsX-like permease family; Region: FtsX; cl15850 288681006642 hypothetical protein; Provisional; Region: PRK06760; cl11698 288681006643 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 288681006644 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 288681006645 homoserine dehydrogenase; Validated; Region: PRK06813 288681006646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006647 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681006648 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006650 DNA-binding site [nucleotide binding]; DNA binding site 288681006651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006653 homodimer interface [polypeptide binding]; other site 288681006654 catalytic residue [active] 288681006655 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 288681006656 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 288681006657 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681006658 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 288681006659 Septum formation initiator; Region: DivIC; cl11433 288681006660 Terminase small subunit; Region: Terminase_2; cl01513 288681006661 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 288681006662 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 288681006663 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 288681006664 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 288681006665 Protein of unknown function; Region: DUF3658; pfam12395 288681006666 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 288681006667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006668 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006670 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 288681006671 trimer interface [polypeptide binding]; other site 288681006672 active site 288681006673 substrate binding site [chemical binding]; other site 288681006674 CoA binding site [chemical binding]; other site 288681006675 Helix-turn-helix domains; Region: HTH; cl00088 288681006676 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 288681006677 Cysteine dioxygenase type I; Region: CDO_I; cl15835 288681006678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681006679 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681006680 active site 288681006681 motif I; other site 288681006682 motif II; other site 288681006683 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681006684 PAS domain S-box; Region: sensory_box; TIGR00229 288681006685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681006686 putative active site [active] 288681006687 heme pocket [chemical binding]; other site 288681006688 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 288681006689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681006690 dimer interface [polypeptide binding]; other site 288681006691 phosphorylation site [posttranslational modification] 288681006692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006693 ATP binding site [chemical binding]; other site 288681006694 Mg2+ binding site [ion binding]; other site 288681006695 G-X-G motif; other site 288681006696 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681006697 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006700 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288681006701 glycosyltransferase, MGT family; Region: MGT; TIGR01426 288681006702 active site 288681006703 TDP-binding site; other site 288681006704 acceptor substrate-binding pocket; other site 288681006705 homodimer interface [polypeptide binding]; other site 288681006706 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288681006707 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681006708 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 288681006709 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 288681006710 Walker A/P-loop; other site 288681006711 ATP binding site [chemical binding]; other site 288681006712 Q-loop/lid; other site 288681006713 ABC transporter signature motif; other site 288681006714 Walker B; other site 288681006715 D-loop; other site 288681006716 H-loop/switch region; other site 288681006717 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 288681006718 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 288681006719 Walker A/P-loop; other site 288681006720 ATP binding site [chemical binding]; other site 288681006721 Q-loop/lid; other site 288681006722 ABC transporter signature motif; other site 288681006723 Walker B; other site 288681006724 D-loop; other site 288681006725 H-loop/switch region; other site 288681006726 Cobalt transport protein; Region: CbiQ; cl00463 288681006727 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681006728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681006729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681006730 dimer interface [polypeptide binding]; other site 288681006731 phosphorylation site [posttranslational modification] 288681006732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006733 ATP binding site [chemical binding]; other site 288681006734 Mg2+ binding site [ion binding]; other site 288681006735 G-X-G motif; other site 288681006736 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006737 active site 288681006738 ATP binding site [chemical binding]; other site 288681006739 substrate binding site [chemical binding]; other site 288681006740 activation loop (A-loop); other site 288681006741 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681006742 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681006743 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288681006744 NAD(P) binding site [chemical binding]; other site 288681006745 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681006746 active site 288681006747 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 288681006748 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006750 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 288681006751 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 288681006752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006753 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006754 putative substrate translocation pore; other site 288681006755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006756 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681006757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006758 Coenzyme A binding pocket [chemical binding]; other site 288681006759 VanZ like family; Region: VanZ; cl01971 288681006760 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 288681006761 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 288681006762 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 288681006763 conserved cys residue [active] 288681006764 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 288681006765 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681006766 Helix-turn-helix domains; Region: HTH; cl00088 288681006767 WYL domain; Region: WYL; cl14852 288681006768 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681006769 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 288681006770 conserved cys residue [active] 288681006771 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681006772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681006773 Walker A/P-loop; other site 288681006774 ATP binding site [chemical binding]; other site 288681006775 Q-loop/lid; other site 288681006776 ABC transporter signature motif; other site 288681006777 Walker B; other site 288681006778 D-loop; other site 288681006779 H-loop/switch region; other site 288681006780 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681006781 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681006782 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681006783 Helix-turn-helix domains; Region: HTH; cl00088 288681006784 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 288681006785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 288681006787 nudix motif; other site 288681006788 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 288681006789 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681006790 DNA binding residues [nucleotide binding] 288681006791 putative dimer interface [polypeptide binding]; other site 288681006792 Trm112p-like protein; Region: Trm112p; cl01066 288681006793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006794 S-adenosylmethionine binding site [chemical binding]; other site 288681006795 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006798 Coenzyme A binding pocket [chemical binding]; other site 288681006799 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 288681006800 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 288681006801 active site 288681006802 catalytic site [active] 288681006803 metal binding site [ion binding]; metal-binding site 288681006804 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681006805 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 288681006806 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006808 DNA-binding site [nucleotide binding]; DNA binding site 288681006809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006811 homodimer interface [polypeptide binding]; other site 288681006812 catalytic residue [active] 288681006813 EamA-like transporter family; Region: EamA; cl01037 288681006814 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681006815 EamA-like transporter family; Region: EamA; cl01037 288681006816 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 288681006817 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 288681006819 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681006820 nudix motif; other site 288681006821 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 288681006822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006824 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 288681006825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681006826 putative substrate translocation pore; other site 288681006827 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681006828 nudix motif; other site 288681006829 DNA polymerase III subunit beta; Validated; Region: PRK06673 288681006830 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 288681006831 putative DNA binding surface [nucleotide binding]; other site 288681006832 dimer interface [polypeptide binding]; other site 288681006833 beta-clamp/clamp loader binding surface; other site 288681006834 beta-clamp/translesion DNA polymerase binding surface; other site 288681006835 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681006836 putative active site [active] 288681006837 nucleotide binding site [chemical binding]; other site 288681006838 nudix motif; other site 288681006839 putative metal binding site [ion binding]; other site 288681006840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681006841 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288681006842 homotrimer interaction site [polypeptide binding]; other site 288681006843 putative active site [active] 288681006844 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 288681006845 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 288681006846 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 288681006847 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681006848 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 288681006849 YxiJ-like protein; Region: YxiJ; pfam14176 288681006850 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 288681006851 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 288681006852 active site 288681006853 nucleophile elbow; other site 288681006854 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 288681006855 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006856 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681006857 DinB superfamily; Region: DinB_2; pfam12867 288681006858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681006859 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006860 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 288681006861 Bacitracin resistance protein BacA; Region: BacA; cl00858 288681006862 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681006863 GIY-YIG motif/motif A; other site 288681006864 active site 288681006865 catalytic site [active] 288681006866 putative DNA binding site [nucleotide binding]; other site 288681006867 metal binding site [ion binding]; metal-binding site 288681006868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681006869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006870 Coenzyme A binding pocket [chemical binding]; other site 288681006871 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 288681006872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681006873 active site 288681006874 ATP binding site [chemical binding]; other site 288681006875 substrate binding site [chemical binding]; other site 288681006876 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 288681006877 nudix motif; other site 288681006878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006879 FAD dependent oxidoreductase; Region: DAO; pfam01266 288681006880 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 288681006881 N-acetyltransferase; Region: Acetyltransf_2; cl00949 288681006882 MepB protein; Region: MepB; cl01985 288681006883 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 288681006884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681006885 motif II; other site 288681006886 DinB superfamily; Region: DinB_2; pfam12867 288681006887 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681006888 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 288681006889 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681006890 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681006891 active site 288681006892 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 288681006893 carbohydrate binding site [chemical binding]; other site 288681006894 pullulanase, type I; Region: pulA_typeI; TIGR02104 288681006895 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 288681006896 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 288681006897 Ca binding site [ion binding]; other site 288681006898 active site 288681006899 catalytic site [active] 288681006900 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 288681006901 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681006902 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681006903 active site 288681006904 Zn binding site [ion binding]; other site 288681006905 Putative zinc-finger; Region: zf-HC2; cl15806 288681006906 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 288681006907 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 288681006908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681006909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681006910 DNA binding residues [nucleotide binding] 288681006911 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681006912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681006913 active site 288681006914 metal binding site [ion binding]; metal-binding site 288681006915 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681006916 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 288681006917 SecY translocase; Region: SecY; pfam00344 288681006918 hypothetical protein; Validated; Region: PRK06672 288681006919 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681006920 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681006921 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681006922 EamA-like transporter family; Region: EamA; cl01037 288681006923 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681006924 EamA-like transporter family; Region: EamA; cl01037 288681006925 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006927 DNA-binding site [nucleotide binding]; DNA binding site 288681006928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006930 homodimer interface [polypeptide binding]; other site 288681006931 catalytic residue [active] 288681006932 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681006933 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681006934 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 288681006935 Predicted membrane protein [Function unknown]; Region: COG4129 288681006936 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 288681006937 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681006938 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 288681006939 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 288681006940 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681006941 germination protein YpeB; Region: spore_YpeB; TIGR02889 288681006942 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 288681006943 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 288681006944 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681006945 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 288681006946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681006947 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 288681006948 Putative cyclase; Region: Cyclase; cl00814 288681006949 kynureninase; Region: kynureninase; TIGR01814 288681006950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681006951 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681006952 catalytic residue [active] 288681006953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006954 Helix-turn-helix domains; Region: HTH; cl00088 288681006955 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681006956 nudix motif; other site 288681006957 N-acetyltransferase; Region: Acetyltransf_2; cl00949 288681006958 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288681006959 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 288681006960 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 288681006961 GAF domain; Region: GAF; cl15785 288681006962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681006963 Walker A motif; other site 288681006964 ATP binding site [chemical binding]; other site 288681006965 Walker B motif; other site 288681006966 arginine finger; other site 288681006967 Helix-turn-helix domains; Region: HTH; cl00088 288681006968 NIPSNAP; Region: NIPSNAP; pfam07978 288681006969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681006970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006971 Coenzyme A binding pocket [chemical binding]; other site 288681006972 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681006973 Helix-turn-helix domains; Region: HTH; cl00088 288681006974 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681006975 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 288681006976 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 288681006977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681006978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681006979 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681006980 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681006981 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681006982 E3 interaction surface; other site 288681006983 lipoyl attachment site [posttranslational modification]; other site 288681006984 e3 binding domain; Region: E3_binding; pfam02817 288681006985 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 288681006986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681006987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681006988 alpha subunit interface [polypeptide binding]; other site 288681006989 TPP binding site [chemical binding]; other site 288681006990 heterodimer interface [polypeptide binding]; other site 288681006991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681006992 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 288681006993 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288681006994 tetramer interface [polypeptide binding]; other site 288681006995 TPP-binding site [chemical binding]; other site 288681006996 heterodimer interface [polypeptide binding]; other site 288681006997 phosphorylation loop region [posttranslational modification] 288681006998 DinB superfamily; Region: DinB_2; pfam12867 288681006999 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681007000 short chain dehydrogenase; Provisional; Region: PRK06914 288681007001 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 288681007002 NADP binding site [chemical binding]; other site 288681007003 active site 288681007004 steroid binding site; other site 288681007005 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681007006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007007 AAA domain; Region: AAA_18; pfam13238 288681007008 active site 288681007009 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 288681007010 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681007011 nudix motif; other site 288681007012 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 288681007013 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681007014 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681007015 nucleotide binding site/active site [active] 288681007016 HIT family signature motif; other site 288681007017 catalytic residue [active] 288681007018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681007019 dimer interface [polypeptide binding]; other site 288681007020 conserved gate region; other site 288681007021 putative PBP binding loops; other site 288681007022 ABC-ATPase subunit interface; other site 288681007023 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 288681007024 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 288681007025 Walker A/P-loop; other site 288681007026 ATP binding site [chemical binding]; other site 288681007027 Q-loop/lid; other site 288681007028 ABC transporter signature motif; other site 288681007029 Walker B; other site 288681007030 D-loop; other site 288681007031 H-loop/switch region; other site 288681007032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 288681007033 NMT1-like family; Region: NMT1_2; cl15260 288681007034 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 288681007035 Clp protease; Region: CLP_protease; pfam00574 288681007036 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288681007037 oligomer interface [polypeptide binding]; other site 288681007038 active site residues [active] 288681007039 RNA polymerase factor sigma-70; Validated; Region: PRK06704 288681007040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681007041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681007042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288681007043 catalytic loop [active] 288681007044 iron binding site [ion binding]; other site 288681007045 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 288681007046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681007047 active site 288681007048 dimer interface [polypeptide binding]; other site 288681007049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007050 Coenzyme A binding pocket [chemical binding]; other site 288681007051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 288681007052 Chitin binding domain; Region: Chitin_bind_3; cl03871 288681007053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681007054 Interdomain contacts; other site 288681007055 Cytokine receptor motif; other site 288681007056 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681007057 Interdomain contacts; other site 288681007058 Cytokine receptor motif; other site 288681007059 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 288681007060 topology modulation protein; Reviewed; Region: PRK08118 288681007061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007062 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 288681007063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007064 active site 288681007065 ATP binding site [chemical binding]; other site 288681007066 substrate binding site [chemical binding]; other site 288681007067 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 288681007068 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 288681007069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007070 S-adenosylmethionine binding site [chemical binding]; other site 288681007071 Protein of unknown function (DUF419); Region: DUF419; cl15265 288681007072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007073 Coenzyme A binding pocket [chemical binding]; other site 288681007074 S-layer homology domain; Region: SLH; pfam00395 288681007075 S-layer homology domain; Region: SLH; pfam00395 288681007076 S-layer homology domain; Region: SLH; pfam00395 288681007077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681007078 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 288681007079 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 288681007080 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 288681007081 active site 288681007082 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 288681007083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007084 Coenzyme A binding pocket [chemical binding]; other site 288681007085 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 288681007086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007087 Coenzyme A binding pocket [chemical binding]; other site 288681007088 Helix-turn-helix domains; Region: HTH; cl00088 288681007089 Protein of unknown function (DUF952); Region: DUF952; cl01393 288681007090 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 288681007091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007092 Family description; Region: UvrD_C_2; cl15862 288681007093 CAAX protease self-immunity; Region: Abi; cl00558 288681007094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007095 S-adenosylmethionine binding site [chemical binding]; other site 288681007096 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 288681007097 putative active site pocket [active] 288681007098 dimerization interface [polypeptide binding]; other site 288681007099 putative catalytic residue [active] 288681007100 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 288681007101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681007102 ATP binding site [chemical binding]; other site 288681007103 putative Mg++ binding site [ion binding]; other site 288681007104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681007105 nucleotide binding region [chemical binding]; other site 288681007106 ATP-binding site [chemical binding]; other site 288681007107 RQC domain; Region: RQC; cl09632 288681007108 HRDC domain; Region: HRDC; cl02578 288681007109 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 288681007110 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681007111 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681007112 active site 288681007113 Zn binding site [ion binding]; other site 288681007114 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 288681007115 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 288681007116 DHHA2 domain; Region: DHHA2; pfam02833 288681007117 Chitin binding domain; Region: Chitin_bind_3; cl03871 288681007118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681007119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007120 Coenzyme A binding pocket [chemical binding]; other site 288681007121 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 288681007122 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681007123 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681007124 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 288681007125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681007126 NAD(P) binding site [chemical binding]; other site 288681007127 catalytic residues [active] 288681007128 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288681007129 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 288681007130 inhibitor site; inhibition site 288681007131 active site 288681007132 dimer interface [polypeptide binding]; other site 288681007133 catalytic residue [active] 288681007134 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 288681007135 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681007136 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681007137 Proline racemase; Region: Pro_racemase; pfam05544 288681007138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007139 FAD dependent oxidoreductase; Region: DAO; pfam01266 288681007140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681007141 PAS domain; Region: PAS_10; pfam13596 288681007142 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 288681007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007144 Walker A motif; other site 288681007145 ATP binding site [chemical binding]; other site 288681007146 Walker B motif; other site 288681007147 arginine finger; other site 288681007148 Helix-turn-helix domains; Region: HTH; cl00088 288681007149 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 288681007150 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 288681007151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 288681007152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007153 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 288681007154 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 288681007155 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681007156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681007157 active site 288681007158 metal binding site [ion binding]; metal-binding site 288681007159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007160 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007161 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 288681007162 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681007163 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681007164 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681007165 DinB superfamily; Region: DinB_2; pfam12867 288681007166 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681007167 DltD N-terminal region; Region: DltD_N; pfam04915 288681007168 DltD central region; Region: DltD_M; pfam04918 288681007169 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288681007170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007171 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007172 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681007173 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681007174 peptide binding site [polypeptide binding]; other site 288681007175 NlpC/P60 family; Region: NLPC_P60; cl11438 288681007176 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 288681007177 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 288681007178 active site 288681007179 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 288681007180 Septum formation initiator; Region: DivIC; cl11433 288681007181 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 288681007182 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 288681007183 conserved cys residue [active] 288681007184 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681007185 active site 288681007186 catalytic motif [active] 288681007187 Zn binding site [ion binding]; other site 288681007188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007189 S-adenosylmethionine binding site [chemical binding]; other site 288681007190 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 288681007191 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 288681007192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681007193 dimerization interface [polypeptide binding]; other site 288681007194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681007195 dimer interface [polypeptide binding]; other site 288681007196 phosphorylation site [posttranslational modification] 288681007197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007198 ATP binding site [chemical binding]; other site 288681007199 Mg2+ binding site [ion binding]; other site 288681007200 G-X-G motif; other site 288681007201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681007202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681007203 active site 288681007204 phosphorylation site [posttranslational modification] 288681007205 intermolecular recognition site; other site 288681007206 dimerization interface [polypeptide binding]; other site 288681007207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681007208 DNA binding site [nucleotide binding] 288681007209 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681007210 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 288681007211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007212 motif II; other site 288681007213 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288681007214 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007215 substrate binding site [chemical binding]; other site 288681007216 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007217 active site 288681007218 ATP binding site [chemical binding]; other site 288681007219 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 288681007220 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681007221 Zn binding site [ion binding]; other site 288681007222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681007223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681007224 non-specific DNA binding site [nucleotide binding]; other site 288681007225 salt bridge; other site 288681007226 sequence-specific DNA binding site [nucleotide binding]; other site 288681007227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681007228 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 288681007229 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007230 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007231 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007232 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007235 putative substrate translocation pore; other site 288681007236 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 288681007237 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 288681007238 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 288681007239 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 288681007240 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 288681007241 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 288681007242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007244 putative substrate translocation pore; other site 288681007245 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 288681007246 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681007247 active site 288681007248 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 288681007249 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681007250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007251 S-adenosylmethionine binding site [chemical binding]; other site 288681007252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007253 putative substrate translocation pore; other site 288681007254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007255 aspartate aminotransferase; Provisional; Region: PRK07681 288681007256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007258 homodimer interface [polypeptide binding]; other site 288681007259 catalytic residue [active] 288681007260 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 288681007261 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681007262 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 288681007263 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 288681007264 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 288681007265 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 288681007266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681007267 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681007268 Walker A/P-loop; other site 288681007269 ATP binding site [chemical binding]; other site 288681007270 Q-loop/lid; other site 288681007271 ABC transporter signature motif; other site 288681007272 Walker B; other site 288681007273 D-loop; other site 288681007274 H-loop/switch region; other site 288681007275 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681007276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007277 DNA-binding site [nucleotide binding]; DNA binding site 288681007278 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681007279 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 288681007280 HNH endonuclease; Region: HNH_5; pfam14279 288681007281 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 288681007282 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 288681007283 active site 288681007284 dimer interface [polypeptide binding]; other site 288681007285 non-prolyl cis peptide bond; other site 288681007286 insertion regions; other site 288681007287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681007288 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 288681007289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681007290 substrate binding pocket [chemical binding]; other site 288681007291 membrane-bound complex binding site; other site 288681007292 hinge residues; other site 288681007293 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681007294 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 288681007295 Walker A/P-loop; other site 288681007296 ATP binding site [chemical binding]; other site 288681007297 Q-loop/lid; other site 288681007298 ABC transporter signature motif; other site 288681007299 Walker B; other site 288681007300 D-loop; other site 288681007301 H-loop/switch region; other site 288681007302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681007303 Helix-turn-helix domains; Region: HTH; cl00088 288681007304 Protein of unknown function (DUF402); Region: DUF402; cl00979 288681007305 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 288681007306 nudix motif; other site 288681007307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681007308 binding surface 288681007309 TPR motif; other site 288681007310 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 288681007311 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 288681007312 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 288681007313 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007314 EamA-like transporter family; Region: EamA; cl01037 288681007315 DinB superfamily; Region: DinB_2; pfam12867 288681007316 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681007317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681007318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007319 Coenzyme A binding pocket [chemical binding]; other site 288681007320 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007321 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007322 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681007323 active site 288681007324 NTP binding site [chemical binding]; other site 288681007325 metal binding triad [ion binding]; metal-binding site 288681007326 antibiotic binding site [chemical binding]; other site 288681007327 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681007328 A new structural DNA glycosylase; Region: AlkD_like; cd06561 288681007329 active site 288681007330 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681007331 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681007332 NodB motif; other site 288681007333 active site 288681007334 catalytic site [active] 288681007335 Zn binding site [ion binding]; other site 288681007336 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 288681007337 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 288681007338 active site 288681007339 P-loop; other site 288681007340 phosphorylation site [posttranslational modification] 288681007341 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 288681007342 Helix-turn-helix domains; Region: HTH; cl00088 288681007343 Helix-turn-helix domains; Region: HTH; cl00088 288681007344 PRD domain; Region: PRD; cl15445 288681007345 PRD domain; Region: PRD; cl15445 288681007346 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 288681007347 active site 288681007348 P-loop; other site 288681007349 phosphorylation site [posttranslational modification] 288681007350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681007351 active site 288681007352 phosphorylation site [posttranslational modification] 288681007353 Integral membrane protein TerC family; Region: TerC; cl10468 288681007354 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681007355 Sulfatase; Region: Sulfatase; cl10460 288681007356 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 288681007357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007358 Walker A/P-loop; other site 288681007359 ATP binding site [chemical binding]; other site 288681007360 Q-loop/lid; other site 288681007361 ABC transporter signature motif; other site 288681007362 Walker B; other site 288681007363 D-loop; other site 288681007364 H-loop/switch region; other site 288681007365 ABC transporter; Region: ABC_tran_2; pfam12848 288681007366 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681007367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007368 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 288681007369 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 288681007370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681007371 Helix-turn-helix domains; Region: HTH; cl00088 288681007372 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007373 Sterol carrier protein domain; Region: SCP2_2; pfam13530 288681007374 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 288681007375 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 288681007376 hinge; other site 288681007377 active site 288681007378 prephenate dehydrogenase; Validated; Region: PRK06545 288681007379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007380 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 288681007381 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 288681007382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007384 homodimer interface [polypeptide binding]; other site 288681007385 catalytic residue [active] 288681007386 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 288681007387 Tetramer interface [polypeptide binding]; other site 288681007388 active site 288681007389 FMN-binding site [chemical binding]; other site 288681007390 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 288681007391 Chorismate mutase type II; Region: CM_2; cl00693 288681007392 NeuB family; Region: NeuB; cl00496 288681007393 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 288681007394 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 288681007395 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 288681007396 Isochorismatase family; Region: Isochorismatase; pfam00857 288681007397 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681007398 catalytic triad [active] 288681007399 conserved cis-peptide bond; other site 288681007400 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681007401 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007402 YfzA-like protein; Region: YfzA; pfam14118 288681007403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007404 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 288681007405 Bacterial SH3 domain; Region: SH3_3; cl02551 288681007406 Bacterial SH3 domain; Region: SH3_3; cl02551 288681007407 3D domain; Region: 3D; cl01439 288681007408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007409 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007410 Citrate transporter; Region: CitMHS; pfam03600 288681007411 enoyl-CoA hydratase; Provisional; Region: PRK06688 288681007412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681007413 substrate binding site [chemical binding]; other site 288681007414 oxyanion hole (OAH) forming residues; other site 288681007415 trimer interface [polypeptide binding]; other site 288681007416 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 288681007417 AMP-binding enzyme; Region: AMP-binding; cl15778 288681007418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007419 Walker B motif; other site 288681007420 arginine finger; other site 288681007421 Helix-turn-helix domains; Region: HTH; cl00088 288681007422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681007423 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681007424 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 288681007425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007426 Predicted dehydrogenase [General function prediction only]; Region: COG0579 288681007427 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 288681007428 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 288681007429 ligand binding site [chemical binding]; other site 288681007430 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681007431 TM-ABC transporter signature motif; other site 288681007432 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681007433 TM-ABC transporter signature motif; other site 288681007434 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 288681007435 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 288681007436 Walker A/P-loop; other site 288681007437 ATP binding site [chemical binding]; other site 288681007438 Q-loop/lid; other site 288681007439 ABC transporter signature motif; other site 288681007440 Walker B; other site 288681007441 D-loop; other site 288681007442 H-loop/switch region; other site 288681007443 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 288681007444 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681007445 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681007446 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 288681007447 Autoinducer-2 kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 288681007448 putative N- and C-terminal domain interface [polypeptide binding]; other site 288681007449 putative active site [active] 288681007450 putative MgATP binding site [chemical binding]; other site 288681007451 catalytic site [active] 288681007452 metal binding site [ion binding]; metal-binding site 288681007453 putative carbohydrate binding site [chemical binding]; other site 288681007454 Cupin domain; Region: Cupin_2; cl09118 288681007455 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 288681007456 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 288681007457 putative active site; other site 288681007458 catalytic residue [active] 288681007459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007460 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007461 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 288681007462 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681007463 active site 288681007464 NTP binding site [chemical binding]; other site 288681007465 metal binding triad [ion binding]; metal-binding site 288681007466 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681007467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007468 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681007469 putative substrate translocation pore; other site 288681007470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007471 putative DNA binding site [nucleotide binding]; other site 288681007472 putative Zn2+ binding site [ion binding]; other site 288681007473 DinB superfamily; Region: DinB_2; pfam12867 288681007474 nucleoside transporter; Region: nupC; TIGR00804 288681007475 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681007476 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681007477 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 288681007478 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 288681007479 putative catalytic cysteine [active] 288681007480 gamma-glutamyl kinase; Provisional; Region: PRK05429 288681007481 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 288681007482 nucleotide binding site [chemical binding]; other site 288681007483 homotetrameric interface [polypeptide binding]; other site 288681007484 putative phosphate binding site [ion binding]; other site 288681007485 putative allosteric binding site; other site 288681007486 PUA domain; Region: PUA; cl00607 288681007487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007488 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 288681007489 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 288681007490 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 288681007491 putative metal binding site [ion binding]; other site 288681007492 putative dimer interface [polypeptide binding]; other site 288681007493 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681007494 Helix-turn-helix domains; Region: HTH; cl00088 288681007495 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681007496 S-methylmethionine transporter; Provisional; Region: PRK11387 288681007497 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 288681007498 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 288681007499 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 288681007500 putative di-iron ligands [ion binding]; other site 288681007501 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 288681007502 dimer interface [polypeptide binding]; other site 288681007503 Alkaline phosphatase homologues; Region: alkPPc; smart00098 288681007504 active site 288681007505 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 288681007506 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 288681007507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681007508 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 288681007509 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 288681007510 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 288681007511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 288681007512 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681007513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 288681007514 active site 288681007515 phosphorylation site [posttranslational modification] 288681007516 intermolecular recognition site; other site 288681007517 dimerization interface [polypeptide binding]; other site 288681007518 LytTr DNA-binding domain; Region: LytTR; cl04498 288681007519 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288681007520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007521 motif II; other site 288681007522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007524 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681007526 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681007527 active site 288681007528 metal binding site [ion binding]; metal-binding site 288681007529 CAAX protease self-immunity; Region: Abi; cl00558 288681007530 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 288681007531 Helix-turn-helix domains; Region: HTH; cl00088 288681007532 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007534 Walker A motif; other site 288681007535 ATP binding site [chemical binding]; other site 288681007536 Walker B motif; other site 288681007537 arginine finger; other site 288681007538 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681007539 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681007540 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 288681007541 proline/glycine betaine transporter; Provisional; Region: PRK10642 288681007542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007543 putative substrate translocation pore; other site 288681007544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007545 active site 288681007546 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007547 active site 288681007548 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681007549 Ligand binding site; other site 288681007550 Putative Catalytic site; other site 288681007551 DXD motif; other site 288681007552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007553 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681007554 Ligand binding site; other site 288681007555 Putative Catalytic site; other site 288681007556 DXD motif; other site 288681007557 acetylornithine aminotransferase; Provisional; Region: PRK02627 288681007558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681007559 inhibitor-cofactor binding pocket; inhibition site 288681007560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007561 catalytic residue [active] 288681007562 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681007563 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681007564 tetramer interface [polypeptide binding]; other site 288681007565 heme binding pocket [chemical binding]; other site 288681007566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681007567 dimer interface [polypeptide binding]; other site 288681007568 conserved gate region; other site 288681007569 putative PBP binding loops; other site 288681007570 ABC-ATPase subunit interface; other site 288681007571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681007572 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 288681007573 Walker A/P-loop; other site 288681007574 ATP binding site [chemical binding]; other site 288681007575 Q-loop/lid; other site 288681007576 ABC transporter signature motif; other site 288681007577 Walker B; other site 288681007578 D-loop; other site 288681007579 H-loop/switch region; other site 288681007580 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 288681007581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681007582 membrane-bound complex binding site; other site 288681007583 hinge residues; other site 288681007584 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 288681007585 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681007586 Helix-turn-helix domains; Region: HTH; cl00088 288681007587 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 288681007588 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288681007589 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 288681007590 active site 288681007591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288681007592 LysE type translocator; Region: LysE; cl00565 288681007593 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681007595 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 288681007596 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681007597 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681007598 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681007599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007600 Walker A motif; other site 288681007601 ATP binding site [chemical binding]; other site 288681007602 Walker B motif; other site 288681007603 arginine finger; other site 288681007604 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681007605 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681007606 dimer interface [polypeptide binding]; other site 288681007607 FMN binding site [chemical binding]; other site 288681007608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681007609 Helix-turn-helix domains; Region: HTH; cl00088 288681007610 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 288681007611 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 288681007612 G1 box; other site 288681007613 putative GEF interaction site [polypeptide binding]; other site 288681007614 GTP/Mg2+ binding site [chemical binding]; other site 288681007615 Switch I region; other site 288681007616 G2 box; other site 288681007617 G3 box; other site 288681007618 Switch II region; other site 288681007619 G4 box; other site 288681007620 G5 box; other site 288681007621 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 288681007622 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 288681007623 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 288681007624 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681007625 nudix motif; other site 288681007626 YfzA-like protein; Region: YfzA; pfam14118 288681007627 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681007628 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681007629 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681007630 Walker A/P-loop; other site 288681007631 ATP binding site [chemical binding]; other site 288681007632 Q-loop/lid; other site 288681007633 ABC transporter signature motif; other site 288681007634 Walker B; other site 288681007635 D-loop; other site 288681007636 H-loop/switch region; other site 288681007637 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681007638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007639 DNA-binding site [nucleotide binding]; DNA binding site 288681007640 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 288681007641 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681007642 putative NAD(P) binding site [chemical binding]; other site 288681007643 active site 288681007644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681007645 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681007646 Walker A/P-loop; other site 288681007647 ATP binding site [chemical binding]; other site 288681007648 Q-loop/lid; other site 288681007649 ABC transporter signature motif; other site 288681007650 Walker B; other site 288681007651 D-loop; other site 288681007652 H-loop/switch region; other site 288681007653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681007654 FtsX-like permease family; Region: FtsX; cl15850 288681007655 FtsX-like permease family; Region: FtsX; cl15850 288681007656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681007657 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 288681007658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681007659 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681007660 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 288681007661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007662 Coenzyme A binding pocket [chemical binding]; other site 288681007663 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 288681007664 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 288681007665 nudix motif; other site 288681007666 EamA-like transporter family; Region: EamA; cl01037 288681007667 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681007668 EamA-like transporter family; Region: EamA; cl01037 288681007669 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681007670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007671 DNA-binding site [nucleotide binding]; DNA binding site 288681007672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007674 homodimer interface [polypeptide binding]; other site 288681007675 catalytic residue [active] 288681007676 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 288681007677 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 288681007678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681007679 phosphorylation site [posttranslational modification] 288681007680 dimer interface [polypeptide binding]; other site 288681007681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007682 ATP binding site [chemical binding]; other site 288681007683 Mg2+ binding site [ion binding]; other site 288681007684 G-X-G motif; other site 288681007685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681007686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681007687 active site 288681007688 phosphorylation site [posttranslational modification] 288681007689 intermolecular recognition site; other site 288681007690 dimerization interface [polypeptide binding]; other site 288681007691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681007692 DNA binding site [nucleotide binding] 288681007693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681007694 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681007695 uridine kinase; Validated; Region: PRK06696 288681007696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007697 active site 288681007698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681007699 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681007700 active site 288681007701 metal binding site [ion binding]; metal-binding site 288681007702 Phosphotransferase enzyme family; Region: APH; pfam01636 288681007703 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007704 active site 288681007705 substrate binding site [chemical binding]; other site 288681007706 ATP binding site [chemical binding]; other site 288681007707 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681007708 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681007709 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681007710 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007711 lysine transporter; Provisional; Region: PRK10836 288681007712 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 288681007713 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681007714 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681007715 DNA binding residues [nucleotide binding] 288681007716 dimer interface [polypeptide binding]; other site 288681007717 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681007719 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681007720 putative active site [active] 288681007721 nucleotide binding site [chemical binding]; other site 288681007722 nudix motif; other site 288681007723 putative metal binding site [ion binding]; other site 288681007724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681007725 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681007726 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681007727 Catalytic site [active] 288681007728 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681007729 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681007730 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681007731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681007732 NAD-dependent deacetylase; Provisional; Region: PRK00481 288681007733 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 288681007734 NAD+ binding site [chemical binding]; other site 288681007735 substrate binding site [chemical binding]; other site 288681007736 Zn binding site [ion binding]; other site 288681007737 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 288681007738 putative substrate binding pocket [chemical binding]; other site 288681007739 AC domain interface; other site 288681007740 catalytic triad [active] 288681007741 AB domain interface; other site 288681007742 interchain disulfide; other site 288681007743 Protein of unknown function (DUF979); Region: DUF979; cl01572 288681007744 Protein of unknown function (DUF969); Region: DUF969; cl01573 288681007745 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 288681007746 putative active site [active] 288681007747 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 288681007748 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 288681007749 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 288681007750 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681007751 Helix-turn-helix domains; Region: HTH; cl00088 288681007752 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681007753 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681007754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681007755 Catalytic site [active] 288681007756 CutC family; Region: CutC; cl01218 288681007757 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 288681007758 stage II sporulation protein P; Region: spore_II_P; TIGR02867 288681007759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007760 dimerization interface [polypeptide binding]; other site 288681007761 putative DNA binding site [nucleotide binding]; other site 288681007762 putative Zn2+ binding site [ion binding]; other site 288681007763 DinB superfamily; Region: DinB_2; pfam12867 288681007764 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681007765 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681007766 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 288681007767 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681007768 putative active site [active] 288681007769 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681007770 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 288681007772 Nucleoside recognition; Region: Gate; cl00486 288681007773 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681007774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007775 Coenzyme A binding pocket [chemical binding]; other site 288681007776 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681007777 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681007778 Helix-turn-helix domains; Region: HTH; cl00088 288681007779 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681007780 phosphoenolpyruvate synthase; Validated; Region: PRK06241 288681007781 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 288681007782 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 288681007783 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 288681007784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681007785 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 288681007786 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 288681007787 Coat F domain; Region: Coat_F; cl15836 288681007788 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 288681007789 LysE type translocator; Region: LysE; cl00565 288681007790 Spore germination protein; Region: Spore_permease; cl15802 288681007791 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681007792 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 288681007793 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 288681007794 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681007795 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 288681007796 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681007797 NAD binding site [chemical binding]; other site 288681007798 catalytic Zn binding site [ion binding]; other site 288681007799 structural Zn binding site [ion binding]; other site 288681007800 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 288681007801 dimanganese center [ion binding]; other site 288681007802 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681007803 DNA binding residues [nucleotide binding] 288681007804 dimer interface [polypeptide binding]; other site 288681007805 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681007806 FtsX-like permease family; Region: FtsX; cl15850 288681007807 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681007808 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681007809 Walker A/P-loop; other site 288681007810 ATP binding site [chemical binding]; other site 288681007811 Q-loop/lid; other site 288681007812 ABC transporter signature motif; other site 288681007813 Walker B; other site 288681007814 D-loop; other site 288681007815 H-loop/switch region; other site 288681007816 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681007817 aspartate ammonia-lyase; Provisional; Region: PRK14515 288681007818 Aspartase; Region: Aspartase; cd01357 288681007819 active sites [active] 288681007820 tetramer interface [polypeptide binding]; other site 288681007821 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 288681007822 active site 288681007823 homodimer interface [polypeptide binding]; other site 288681007824 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681007825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681007826 non-specific DNA binding site [nucleotide binding]; other site 288681007827 salt bridge; other site 288681007828 sequence-specific DNA binding site [nucleotide binding]; other site 288681007829 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681007830 GIY-YIG motif/motif A; other site 288681007831 active site 288681007832 catalytic site [active] 288681007833 putative DNA binding site [nucleotide binding]; other site 288681007834 metal binding site [ion binding]; metal-binding site 288681007835 amino acid transporter; Region: 2A0306; TIGR00909 288681007836 Spore germination protein; Region: Spore_permease; cl15802 288681007837 Spore germination protein; Region: Spore_permease; cl15802 288681007838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681007839 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 288681007840 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681007841 Spore germination protein; Region: Spore_permease; cl15802 288681007842 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681007843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681007844 Response regulator receiver domain; Region: Response_reg; pfam00072 288681007845 active site 288681007846 phosphorylation site [posttranslational modification] 288681007847 intermolecular recognition site; other site 288681007848 dimerization interface [polypeptide binding]; other site 288681007849 YcbB domain; Region: YcbB; pfam08664 288681007850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681007851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007852 ATP binding site [chemical binding]; other site 288681007853 Mg2+ binding site [ion binding]; other site 288681007854 G-X-G motif; other site 288681007855 Glutaminase; Region: Glutaminase; cl00907 288681007856 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681007857 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681007858 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 288681007859 transmembrane helices; other site 288681007860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681007861 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681007862 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 288681007863 [2Fe-2S] cluster binding site [ion binding]; other site 288681007864 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681007865 MatE; Region: MatE; cl10513 288681007866 MatE; Region: MatE; cl10513 288681007867 amino acid transporter; Region: 2A0306; TIGR00909 288681007868 Spore germination protein; Region: Spore_permease; cl15802 288681007869 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681007870 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 288681007871 putative active site [active] 288681007872 putative metal binding site [ion binding]; other site 288681007873 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681007874 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681007875 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681007876 tetramer interface [polypeptide binding]; other site 288681007877 heme binding pocket [chemical binding]; other site 288681007878 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 288681007879 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 288681007880 plasmid segregation protein ParM; Provisional; Region: PRK13917 288681007881 Heat induced stress protein YflT; Region: YflT; pfam11181 288681007882 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681007883 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681007884 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 288681007885 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 288681007886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 288681007887 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 288681007888 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 288681007889 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 288681007890 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 288681007891 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 288681007892 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 288681007893 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 288681007894 homodimer interface [polypeptide binding]; other site 288681007895 putative substrate binding pocket [chemical binding]; other site 288681007896 diiron center [ion binding]; other site 288681007897 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681007898 putative active site [active] 288681007899 catalytic site [active] 288681007900 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681007901 PLD-like domain; Region: PLDc_2; pfam13091 288681007902 putative active site [active] 288681007903 catalytic site [active] 288681007904 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681007905 UbiA prenyltransferase family; Region: UbiA; cl00337 288681007906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681007907 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681007908 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 288681007909 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681007910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681007911 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681007912 Walker A/P-loop; other site 288681007913 ATP binding site [chemical binding]; other site 288681007914 Q-loop/lid; other site 288681007915 ABC transporter signature motif; other site 288681007916 Walker B; other site 288681007917 D-loop; other site 288681007918 H-loop/switch region; other site 288681007919 FtsX-like permease family; Region: FtsX; cl15850 288681007920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681007921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007922 ATP binding site [chemical binding]; other site 288681007923 Mg2+ binding site [ion binding]; other site 288681007924 G-X-G motif; other site 288681007925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681007927 active site 288681007928 dimerization interface [polypeptide binding]; other site 288681007929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681007930 DNA binding residues [nucleotide binding] 288681007931 dimerization interface [polypeptide binding]; other site 288681007932 Phosphotransferase enzyme family; Region: APH; pfam01636 288681007933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007934 active site 288681007935 ATP binding site [chemical binding]; other site 288681007936 substrate binding site [chemical binding]; other site 288681007937 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681007938 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681007939 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 288681007940 active site 288681007941 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681007942 Membrane transport protein; Region: Mem_trans; cl09117 288681007943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681007944 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 288681007945 putative metal binding site [ion binding]; other site 288681007946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007947 dimerization interface [polypeptide binding]; other site 288681007948 putative DNA binding site [nucleotide binding]; other site 288681007949 putative Zn2+ binding site [ion binding]; other site 288681007950 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 288681007951 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 288681007952 TPR repeat; Region: TPR_11; pfam13414 288681007953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681007954 binding surface 288681007955 TPR motif; other site 288681007956 Hsp70 protein; Region: HSP70; pfam00012 288681007957 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 288681007958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288681007959 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 288681007960 NADP binding site [chemical binding]; other site 288681007961 homodimer interface [polypeptide binding]; other site 288681007962 active site 288681007963 substrate binding site [chemical binding]; other site 288681007964 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 288681007965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007966 putative DNA binding site [nucleotide binding]; other site 288681007967 putative Zn2+ binding site [ion binding]; other site 288681007968 AsnC family; Region: AsnC_trans_reg; pfam01037 288681007969 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 288681007970 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681007971 metal binding site [ion binding]; metal-binding site 288681007972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681007973 Family description; Region: UvrD_C_2; cl15862 288681007974 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 288681007975 putative active site [active] 288681007976 catalytic site [active] 288681007977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681007978 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681007979 active site 288681007980 metal binding site [ion binding]; metal-binding site 288681007981 HEAT repeats; Region: HEAT_2; pfam13646 288681007982 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 288681007983 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 288681007984 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 288681007985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681007986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681007987 putative transporter; Provisional; Region: PRK11021 288681007988 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681007989 hypothetical protein; Provisional; Region: PRK06770 288681007990 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 288681007991 DoxX; Region: DoxX; cl00976 288681007992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681007993 Helix-turn-helix domains; Region: HTH; cl00088 288681007994 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 288681007995 Cytochrome P450; Region: p450; pfam00067 288681007996 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 288681007997 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681007998 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 288681007999 FAD binding pocket [chemical binding]; other site 288681008000 FAD binding motif [chemical binding]; other site 288681008001 catalytic residues [active] 288681008002 NAD binding pocket [chemical binding]; other site 288681008003 phosphate binding motif [ion binding]; other site 288681008004 beta-alpha-beta structure motif; other site 288681008005 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681008006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008007 putative substrate translocation pore; other site 288681008008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008009 LysE type translocator; Region: LysE; cl00565 288681008010 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 288681008011 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 288681008012 D-cysteine desulfhydrase; Validated; Region: PRK03910 288681008013 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 288681008014 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681008015 catalytic residue [active] 288681008016 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681008017 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681008018 active site 288681008019 metal binding site [ion binding]; metal-binding site 288681008020 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 288681008021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008023 salt bridge; other site 288681008024 non-specific DNA binding site [nucleotide binding]; other site 288681008025 sequence-specific DNA binding site [nucleotide binding]; other site 288681008026 AMP-binding enzyme; Region: AMP-binding; cl15778 288681008027 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 288681008028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681008029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681008030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008031 NAD(P) binding site [chemical binding]; other site 288681008032 active site 288681008033 hypothetical protein; Provisional; Region: PRK06849 288681008034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008035 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681008036 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 288681008037 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681008038 dimer interface [polypeptide binding]; other site 288681008039 active site 288681008040 CoA binding pocket [chemical binding]; other site 288681008041 Leucine carboxyl methyltransferase; Region: LCM; cl01306 288681008042 AAA domain; Region: AAA_33; pfam13671 288681008043 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 288681008044 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 288681008045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008046 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681008047 Walker A/P-loop; other site 288681008048 ATP binding site [chemical binding]; other site 288681008049 Q-loop/lid; other site 288681008050 ABC transporter signature motif; other site 288681008051 Walker B; other site 288681008052 D-loop; other site 288681008053 H-loop/switch region; other site 288681008054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008055 FtsX-like permease family; Region: FtsX; cl15850 288681008056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008057 dimerization interface [polypeptide binding]; other site 288681008058 putative DNA binding site [nucleotide binding]; other site 288681008059 Predicted transcriptional regulator [Transcription]; Region: COG2345 288681008060 putative Zn2+ binding site [ion binding]; other site 288681008061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008062 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681008063 putative substrate translocation pore; other site 288681008064 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 288681008065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681008066 dimerization interface [polypeptide binding]; other site 288681008067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681008068 dimer interface [polypeptide binding]; other site 288681008069 phosphorylation site [posttranslational modification] 288681008070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008071 ATP binding site [chemical binding]; other site 288681008072 Mg2+ binding site [ion binding]; other site 288681008073 G-X-G motif; other site 288681008074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681008075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008076 active site 288681008077 phosphorylation site [posttranslational modification] 288681008078 intermolecular recognition site; other site 288681008079 dimerization interface [polypeptide binding]; other site 288681008080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681008081 DNA binding site [nucleotide binding] 288681008082 Predicted membrane protein [Function unknown]; Region: COG2364 288681008083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681008084 Helix-turn-helix domains; Region: HTH; cl00088 288681008085 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008086 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 288681008087 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681008088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681008089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681008090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008091 D-galactonate transporter; Region: 2A0114; TIGR00893 288681008092 putative substrate translocation pore; other site 288681008093 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 288681008094 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 288681008095 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 288681008096 4Fe-4S binding domain; Region: Fer4; cl02805 288681008097 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 288681008098 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 288681008099 Cysteine-rich domain; Region: CCG; pfam02754 288681008100 Cysteine-rich domain; Region: CCG; pfam02754 288681008101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681008102 Helix-turn-helix domains; Region: HTH; cl00088 288681008103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681008104 dimerization interface [polypeptide binding]; other site 288681008105 2TM domain; Region: 2TM; pfam13239 288681008106 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681008107 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681008108 putative dimer interface [polypeptide binding]; other site 288681008109 catalytic triad [active] 288681008110 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 288681008111 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 288681008112 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 288681008113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008114 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 288681008115 L-serine binding site [chemical binding]; other site 288681008116 ACT domain interface; other site 288681008117 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 288681008118 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 288681008119 homodimer interface [polypeptide binding]; other site 288681008120 substrate-cofactor binding pocket; other site 288681008121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681008122 catalytic residue [active] 288681008123 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681008124 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681008125 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 288681008126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681008127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681008128 Domain of unknown function (DUF378); Region: DUF378; cl00943 288681008129 Cupin domain; Region: Cupin_2; cl09118 288681008130 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681008131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681008132 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 288681008133 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681008134 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681008135 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 288681008136 Penicillin amidase; Region: Penicil_amidase; pfam01804 288681008137 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 288681008138 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 288681008139 active site 288681008140 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 288681008141 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681008142 amidase catalytic site [active] 288681008143 Zn binding residues [ion binding]; other site 288681008144 substrate binding site [chemical binding]; other site 288681008145 Bacterial SH3 domain; Region: SH3_3; cl02551 288681008146 S-layer homology domain; Region: SLH; pfam00395 288681008147 S-layer homology domain; Region: SLH; pfam00395 288681008148 S-layer homology domain; Region: SLH; pfam00395 288681008149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008150 Helix-turn-helix domains; Region: HTH; cl00088 288681008151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008152 putative substrate translocation pore; other site 288681008153 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681008154 A new structural DNA glycosylase; Region: AlkD_like; cd06561 288681008155 active site 288681008156 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 288681008157 S-layer homology domain; Region: SLH; pfam00395 288681008158 S-layer homology domain; Region: SLH; pfam00395 288681008159 S-layer homology domain; Region: SLH; pfam00395 288681008160 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 288681008161 putative metal binding site [ion binding]; other site 288681008162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008163 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 288681008164 NETI protein; Region: NETI; pfam14044 288681008165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008167 putative substrate translocation pore; other site 288681008168 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681008169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681008170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681008171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681008172 Helix-turn-helix domains; Region: HTH; cl00088 288681008173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008175 putative substrate translocation pore; other site 288681008176 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008177 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 288681008178 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 288681008179 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681008180 Uncharacterized conserved protein [Function unknown]; Region: COG4715 288681008181 SWIM zinc finger; Region: SWIM; cl15408 288681008182 YwiC-like protein; Region: YwiC; pfam14256 288681008183 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681008184 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 288681008185 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 288681008186 Walker A/P-loop; other site 288681008187 ATP binding site [chemical binding]; other site 288681008188 Q-loop/lid; other site 288681008189 ABC transporter signature motif; other site 288681008190 Walker B; other site 288681008191 D-loop; other site 288681008192 H-loop/switch region; other site 288681008193 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 288681008194 Walker A/P-loop; other site 288681008195 ATP binding site [chemical binding]; other site 288681008196 Q-loop/lid; other site 288681008197 ABC transporter signature motif; other site 288681008198 Walker B; other site 288681008199 D-loop; other site 288681008200 H-loop/switch region; other site 288681008201 Cobalt transport protein; Region: CbiQ; cl00463 288681008202 Calreticulin family; Region: Calreticulin; pfam00262 288681008203 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 288681008204 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 288681008205 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 288681008206 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 288681008207 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 288681008208 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681008209 DNA binding residues [nucleotide binding] 288681008210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681008211 dimer interface [polypeptide binding]; other site 288681008212 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 288681008213 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681008214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681008215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008216 non-specific DNA binding site [nucleotide binding]; other site 288681008217 salt bridge; other site 288681008218 sequence-specific DNA binding site [nucleotide binding]; other site 288681008219 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 288681008220 putative deacylase active site [active] 288681008221 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681008224 Histidine kinase; Region: HisKA_3; pfam07730 288681008225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008226 ATP binding site [chemical binding]; other site 288681008227 Mg2+ binding site [ion binding]; other site 288681008228 G-X-G motif; other site 288681008229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681008230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008231 active site 288681008232 phosphorylation site [posttranslational modification] 288681008233 intermolecular recognition site; other site 288681008234 dimerization interface [polypeptide binding]; other site 288681008235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681008236 DNA binding residues [nucleotide binding] 288681008237 dimerization interface [polypeptide binding]; other site 288681008238 histidyl-tRNA synthetase; Provisional; Region: PRK12420 288681008239 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 288681008240 dimer interface [polypeptide binding]; other site 288681008241 motif 1; other site 288681008242 active site 288681008243 motif 2; other site 288681008244 motif 3; other site 288681008245 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 288681008246 anticodon binding site; other site 288681008247 Helix-turn-helix domains; Region: HTH; cl00088 288681008248 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 288681008249 dimer interface [polypeptide binding]; other site 288681008250 FMN binding site [chemical binding]; other site 288681008251 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 288681008252 active site 288681008253 domain interfaces; other site 288681008254 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 288681008255 classical (c) SDRs; Region: SDR_c; cd05233 288681008256 NAD(P) binding site [chemical binding]; other site 288681008257 active site 288681008258 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681008259 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681008260 Walker A/P-loop; other site 288681008261 ATP binding site [chemical binding]; other site 288681008262 Q-loop/lid; other site 288681008263 ABC transporter signature motif; other site 288681008264 Walker B; other site 288681008265 D-loop; other site 288681008266 H-loop/switch region; other site 288681008267 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 288681008268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008269 non-specific DNA binding site [nucleotide binding]; other site 288681008270 salt bridge; other site 288681008271 sequence-specific DNA binding site [nucleotide binding]; other site 288681008272 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 288681008273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681008274 motif II; other site 288681008275 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008276 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681008277 active site 288681008278 ATP binding site [chemical binding]; other site 288681008279 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 288681008280 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 288681008281 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 288681008282 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681008283 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681008284 nudix motif; other site 288681008285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 288681008286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008287 putative metal binding site [ion binding]; other site 288681008288 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681008289 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681008290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681008291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681008292 putative substrate translocation pore; other site 288681008293 maltose O-acetyltransferase; Provisional; Region: PRK10092 288681008294 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 288681008295 active site 288681008296 substrate binding site [chemical binding]; other site 288681008297 trimer interface [polypeptide binding]; other site 288681008298 CoA binding site [chemical binding]; other site 288681008299 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 288681008300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008301 FtsX-like permease family; Region: FtsX; cl15850 288681008302 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 288681008303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008304 FtsX-like permease family; Region: FtsX; cl15850 288681008305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008306 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681008307 Walker A/P-loop; other site 288681008308 ATP binding site [chemical binding]; other site 288681008309 Q-loop/lid; other site 288681008310 ABC transporter signature motif; other site 288681008311 Walker B; other site 288681008312 D-loop; other site 288681008313 H-loop/switch region; other site 288681008314 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 288681008315 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288681008316 active site 288681008317 HIGH motif; other site 288681008318 dimer interface [polypeptide binding]; other site 288681008319 KMSKS motif; other site 288681008320 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 288681008321 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 288681008322 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 288681008323 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 288681008324 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 288681008325 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681008326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008327 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008328 Coenzyme A binding pocket [chemical binding]; other site 288681008329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681008330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008331 S-adenosylmethionine binding site [chemical binding]; other site 288681008332 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 288681008333 CGNR zinc finger; Region: zf-CGNR; pfam11706 288681008334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008336 putative substrate translocation pore; other site 288681008337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681008338 binding surface 288681008339 TPR motif; other site 288681008340 TPR repeat; Region: TPR_11; pfam13414 288681008341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681008342 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681008343 TPR motif; other site 288681008344 binding surface 288681008345 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 288681008346 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681008347 hypothetical protein; Provisional; Region: PRK04164 288681008348 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681008349 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681008350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681008351 Transporter associated domain; Region: CorC_HlyC; cl08393 288681008352 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 288681008353 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681008354 DNA binding residues [nucleotide binding] 288681008355 putative dimer interface [polypeptide binding]; other site 288681008356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008357 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 288681008358 substrate binding site; other site 288681008359 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 288681008360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008361 NAD(P) binding site [chemical binding]; other site 288681008362 active site 288681008363 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 288681008364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681008365 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 288681008366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008367 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681008368 NAD(P) binding site [chemical binding]; other site 288681008369 active site 288681008370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008371 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 288681008372 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 288681008373 EamA-like transporter family; Region: EamA; cl01037 288681008374 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681008375 EamA-like transporter family; Region: EamA; cl01037 288681008376 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 288681008377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 288681008378 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 288681008379 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 288681008380 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 288681008381 N- and C-terminal domain interface [polypeptide binding]; other site 288681008382 putative active site [active] 288681008383 catalytic site [active] 288681008384 metal binding site [ion binding]; metal-binding site 288681008385 carbohydrate binding site [chemical binding]; other site 288681008386 ATP binding site [chemical binding]; other site 288681008387 GntP family permease; Region: GntP_permease; pfam02447 288681008388 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 288681008389 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 288681008390 active site 288681008391 intersubunit interactions; other site 288681008392 catalytic residue [active] 288681008393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008394 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 288681008395 transketolase; Reviewed; Region: PRK05899 288681008396 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 288681008397 TPP-binding site [chemical binding]; other site 288681008398 dimer interface [polypeptide binding]; other site 288681008399 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681008400 PYR/PP interface [polypeptide binding]; other site 288681008401 dimer interface [polypeptide binding]; other site 288681008402 TPP binding site [chemical binding]; other site 288681008403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681008404 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 288681008405 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288681008406 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 288681008407 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288681008408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681008409 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288681008410 putative NAD(P) binding site [chemical binding]; other site 288681008411 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 288681008412 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681008413 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 288681008414 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 288681008415 putative NAD(P) binding site [chemical binding]; other site 288681008416 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681008417 classical (c) SDRs; Region: SDR_c; cd05233 288681008418 NAD(P) binding site [chemical binding]; other site 288681008419 active site 288681008420 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681008421 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681008422 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681008423 active site 288681008424 Zn binding site [ion binding]; other site 288681008425 Viral enhancin protein; Region: Enhancin; pfam03272 288681008426 Peptidase M60-like family; Region: M60-like; pfam13402 288681008427 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681008428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681008429 dimerization interface [polypeptide binding]; other site 288681008430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681008431 dimer interface [polypeptide binding]; other site 288681008432 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 288681008433 putative CheW interface [polypeptide binding]; other site 288681008434 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681008435 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288681008436 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681008437 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681008438 catalytic motif [active] 288681008439 Zn binding site [ion binding]; other site 288681008440 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 288681008441 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681008442 dimerization interface [polypeptide binding]; other site 288681008443 active site 288681008444 Helix-turn-helix domains; Region: HTH; cl00088 288681008445 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681008446 dimer interface [polypeptide binding]; other site 288681008447 FMN binding site [chemical binding]; other site 288681008448 BNR repeat-like domain; Region: BNR_2; pfam13088 288681008449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681008450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681008451 active site 288681008452 catalytic tetrad [active] 288681008453 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681008454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008455 putative substrate translocation pore; other site 288681008456 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 288681008457 active site 1 [active] 288681008458 dimer interface [polypeptide binding]; other site 288681008459 hexamer interface [polypeptide binding]; other site 288681008460 active site 2 [active] 288681008461 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 288681008462 Domain of unknown function (DUF336); Region: DUF336; cl01249 288681008463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681008465 active site 288681008466 metal binding site [ion binding]; metal-binding site 288681008467 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 288681008468 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 288681008469 IDEAL domain; Region: IDEAL; cl07452 288681008470 Helix-turn-helix domains; Region: HTH; cl00088 288681008471 Rrf2 family protein; Region: rrf2_super; TIGR00738 288681008472 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 288681008473 ArsC family; Region: ArsC; pfam03960 288681008474 putative catalytic residues [active] 288681008475 thiol/disulfide switch; other site 288681008476 Helix-turn-helix domains; Region: HTH; cl00088 288681008477 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681008478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681008479 DNA-binding site [nucleotide binding]; DNA binding site 288681008480 UTRA domain; Region: UTRA; cl01230 288681008481 putative oxidoreductase; Provisional; Region: PRK10206 288681008482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008483 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681008484 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 288681008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681008486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008487 S-adenosylmethionine binding site [chemical binding]; other site 288681008488 Helix-turn-helix domains; Region: HTH; cl00088 288681008489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008490 dimerization interface [polypeptide binding]; other site 288681008491 putative DNA binding site [nucleotide binding]; other site 288681008492 putative Zn2+ binding site [ion binding]; other site 288681008493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681008494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681008495 active site 288681008496 catalytic tetrad [active] 288681008497 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 288681008498 putative hydrophobic ligand binding site [chemical binding]; other site 288681008499 protein interface [polypeptide binding]; other site 288681008500 gate; other site 288681008501 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 288681008502 catalytic triad [active] 288681008503 oxyanion hole [active] 288681008504 active site 288681008505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681008506 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008507 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681008508 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 288681008509 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681008510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008511 Coenzyme A binding pocket [chemical binding]; other site 288681008512 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681008513 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681008515 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008516 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 288681008517 AMP-binding enzyme; Region: AMP-binding; cl15778 288681008518 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681008519 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681008520 Helix-turn-helix domains; Region: HTH; cl00088 288681008521 hypothetical protein; Provisional; Region: PRK08244 288681008522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008524 dimerization interface [polypeptide binding]; other site 288681008525 putative DNA binding site [nucleotide binding]; other site 288681008526 putative Zn2+ binding site [ion binding]; other site 288681008527 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 288681008528 active site 288681008529 Glyco_18 domain; Region: Glyco_18; smart00636 288681008530 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681008531 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 288681008532 NodB motif; other site 288681008533 putative active site [active] 288681008534 putative catalytic site [active] 288681008535 putative Zn binding site [ion binding]; other site 288681008536 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 288681008537 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 288681008538 DXD motif; other site 288681008539 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 288681008540 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 288681008541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681008542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008543 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 288681008544 active site 288681008545 CAAX protease self-immunity; Region: Abi; cl00558 288681008546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008547 Helix-turn-helix domains; Region: HTH; cl00088 288681008548 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 288681008549 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 288681008550 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681008551 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681008552 Helix-turn-helix domains; Region: HTH; cl00088 288681008553 WYL domain; Region: WYL; cl14852 288681008554 Protein of unknown function (DUF805); Region: DUF805; cl01224 288681008555 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681008556 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681008557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681008558 Walker A/P-loop; other site 288681008559 ATP binding site [chemical binding]; other site 288681008560 Q-loop/lid; other site 288681008561 ABC transporter signature motif; other site 288681008562 Walker B; other site 288681008563 D-loop; other site 288681008564 H-loop/switch region; other site 288681008565 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 288681008566 Helix-turn-helix domains; Region: HTH; cl00088 288681008567 hydroxylamine reductase; Provisional; Region: PRK12310 288681008568 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681008569 ACS interaction site; other site 288681008570 CODH interaction site; other site 288681008571 metal cluster binding site [ion binding]; other site 288681008572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681008573 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 288681008574 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 288681008575 metal binding site [ion binding]; metal-binding site 288681008576 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 288681008577 hypothetical protein; Provisional; Region: PRK06771 288681008578 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008579 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 288681008580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008581 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 288681008582 dimer interface [polypeptide binding]; other site 288681008583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008584 ligand binding site [chemical binding]; other site 288681008585 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 288681008586 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681008587 ligand binding site [chemical binding]; other site 288681008588 flexible hinge region; other site 288681008589 Helix-turn-helix domains; Region: HTH; cl00088 288681008590 Protein of unknown function, DUF606; Region: DUF606; cl01273 288681008591 Protein of unknown function, DUF606; Region: DUF606; cl01273 288681008592 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681008593 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681008594 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681008595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681008596 Walker A motif; other site 288681008597 ATP binding site [chemical binding]; other site 288681008598 Walker B motif; other site 288681008599 arginine finger; other site 288681008600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681008601 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 288681008602 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 288681008603 putative NAD(P) binding site [chemical binding]; other site 288681008604 dimer interface [polypeptide binding]; other site 288681008605 putative transport protein YifK; Provisional; Region: PRK10746 288681008606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008607 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 288681008608 putative substrate translocation pore; other site 288681008609 Haemolysin XhlA; Region: XhlA; pfam10779 288681008610 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 288681008611 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 288681008612 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288681008613 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 288681008614 transmembrane helices; other site 288681008615 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681008616 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008617 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681008618 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681008619 putative ligand binding residues [chemical binding]; other site 288681008620 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681008621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681008622 ABC-ATPase subunit interface; other site 288681008623 dimer interface [polypeptide binding]; other site 288681008624 putative PBP binding regions; other site 288681008625 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681008626 ABC-ATPase subunit interface; other site 288681008627 dimer interface [polypeptide binding]; other site 288681008628 putative PBP binding regions; other site 288681008629 Protein of unknown function (DUF817); Region: DUF817; cl01520 288681008630 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288681008631 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681008632 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 288681008633 DinB superfamily; Region: DinB_2; pfam12867 288681008634 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681008635 CAAX protease self-immunity; Region: Abi; cl00558 288681008636 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 288681008637 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 288681008638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681008639 Helix-turn-helix domains; Region: HTH; cl00088 288681008640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681008641 dimerization interface [polypeptide binding]; other site 288681008642 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681008643 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 288681008644 NADP binding site [chemical binding]; other site 288681008645 dimer interface [polypeptide binding]; other site 288681008646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681008647 catalytic core [active] 288681008648 Predicted acetyltransferase [General function prediction only]; Region: COG3153 288681008649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008650 Coenzyme A binding pocket [chemical binding]; other site 288681008651 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 288681008652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681008653 Walker A/P-loop; other site 288681008654 ATP binding site [chemical binding]; other site 288681008655 Q-loop/lid; other site 288681008656 ABC transporter signature motif; other site 288681008657 Walker B; other site 288681008658 D-loop; other site 288681008659 H-loop/switch region; other site 288681008660 N-acetyltransferase; Region: Acetyltransf_2; cl00949 288681008661 oligoendopeptidase F; Region: pepF; TIGR00181 288681008662 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 288681008663 active site 288681008664 Zn binding site [ion binding]; other site 288681008665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008667 putative substrate translocation pore; other site 288681008668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681008670 Helix-turn-helix domains; Region: HTH; cl00088 288681008671 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 288681008672 putative dimerization interface [polypeptide binding]; other site 288681008673 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 288681008674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681008675 putative active site [active] 288681008676 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 288681008677 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681008678 active site 288681008679 catalytic site [active] 288681008680 metal binding site [ion binding]; metal-binding site 288681008681 FAD binding domain; Region: FAD_binding_3; pfam01494 288681008682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008683 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 288681008684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008685 dimerization interface [polypeptide binding]; other site 288681008686 putative DNA binding site [nucleotide binding]; other site 288681008687 putative Zn2+ binding site [ion binding]; other site 288681008688 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681008689 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288681008690 putative NAD(P) binding site [chemical binding]; other site 288681008691 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 288681008692 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 288681008693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681008694 TPR motif; other site 288681008695 binding surface 288681008696 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 288681008697 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681008698 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681008699 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 288681008700 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 288681008701 Membrane transport protein; Region: Mem_trans; cl09117 288681008702 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 288681008703 FAD binding domain; Region: FAD_binding_4; pfam01565 288681008704 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 288681008705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681008706 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681008707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681008708 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 288681008709 trimer interface [polypeptide binding]; other site 288681008710 active site 288681008711 substrate binding site [chemical binding]; other site 288681008712 CoA binding site [chemical binding]; other site 288681008713 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 288681008714 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 288681008715 inhibitor-cofactor binding pocket; inhibition site 288681008716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681008717 catalytic residue [active] 288681008718 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681008719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008720 active site 288681008721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008722 active site 288681008723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681008725 enoyl-CoA hydratase; Provisional; Region: PRK06688 288681008726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681008727 substrate binding site [chemical binding]; other site 288681008728 oxyanion hole (OAH) forming residues; other site 288681008729 trimer interface [polypeptide binding]; other site 288681008730 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681008731 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681008732 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681008733 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681008734 MgtC family; Region: MgtC; pfam02308 288681008735 Predicted acetyltransferase [General function prediction only]; Region: COG3981 288681008736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008737 Coenzyme A binding pocket [chemical binding]; other site 288681008738 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681008739 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 288681008740 putative metal binding site [ion binding]; other site 288681008741 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681008742 active site 288681008743 metal binding site [ion binding]; metal-binding site 288681008744 VanW like protein; Region: VanW; pfam04294 288681008745 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 288681008746 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 288681008747 exonuclease; Provisional; Region: PRK06722 288681008748 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 288681008749 active site 288681008750 catalytic site [active] 288681008751 substrate binding site [chemical binding]; other site 288681008752 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681008753 DNA-binding site [nucleotide binding]; DNA binding site 288681008754 RNA-binding motif; other site 288681008755 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681008756 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 288681008757 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 288681008758 nudix motif; other site 288681008759 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 288681008760 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 288681008761 trimer interface [polypeptide binding]; other site 288681008762 active site 288681008763 substrate binding site [chemical binding]; other site 288681008764 CoA binding site [chemical binding]; other site 288681008765 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008766 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008767 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008768 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008769 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008770 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008771 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008772 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008773 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008774 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008775 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008776 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008777 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008778 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681008779 short chain dehydrogenase; Provisional; Region: PRK06924 288681008780 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 288681008781 NADP binding site [chemical binding]; other site 288681008782 homodimer interface [polypeptide binding]; other site 288681008783 active site 288681008784 Predicted acetyltransferase [General function prediction only]; Region: COG3393 288681008785 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681008786 argininosuccinate lyase; Provisional; Region: PRK06705 288681008787 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 288681008788 active sites [active] 288681008789 tetramer interface [polypeptide binding]; other site 288681008790 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 288681008791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681008792 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 288681008793 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681008794 active site 288681008795 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681008796 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 288681008797 Na binding site [ion binding]; other site 288681008798 Protein of unknown function (DUF997); Region: DUF997; cl01614 288681008799 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 288681008800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681008801 NAD(P) binding site [chemical binding]; other site 288681008802 catalytic residues [active] 288681008803 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681008804 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288681008805 NAD(P) binding site [chemical binding]; other site 288681008806 homotetramer interface [polypeptide binding]; other site 288681008807 homodimer interface [polypeptide binding]; other site 288681008808 active site 288681008809 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 288681008810 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 288681008811 Divergent PAP2 family; Region: DUF212; cl00855 288681008812 Predicted permeases [General function prediction only]; Region: RarD; COG2962 288681008813 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 288681008814 antiporter inner membrane protein; Provisional; Region: PRK11670 288681008815 Domain of unknown function DUF59; Region: DUF59; cl00941 288681008816 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 288681008817 Walker A motif; other site 288681008818 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681008819 MoaE interaction surface [polypeptide binding]; other site 288681008820 MoeB interaction surface [polypeptide binding]; other site 288681008821 thiocarboxylated glycine; other site 288681008822 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681008823 MoaE homodimer interface [polypeptide binding]; other site 288681008824 MoaD interaction [polypeptide binding]; other site 288681008825 active site residues [active] 288681008826 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681008827 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681008828 dimer interface [polypeptide binding]; other site 288681008829 putative functional site; other site 288681008830 putative MPT binding site; other site 288681008831 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681008832 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681008833 ATP binding site [chemical binding]; other site 288681008834 substrate interface [chemical binding]; other site 288681008835 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 288681008836 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 288681008837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681008838 FeS/SAM binding site; other site 288681008839 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681008840 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 288681008841 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 288681008842 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 288681008843 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 288681008844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 288681008845 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 288681008846 4Fe-4S binding domain; Region: Fer4; cl02805 288681008847 4Fe-4S binding domain; Region: Fer4; cl02805 288681008848 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 288681008849 [4Fe-4S] binding site [ion binding]; other site 288681008850 molybdopterin cofactor binding site; other site 288681008851 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 288681008852 molybdopterin cofactor binding site; other site 288681008853 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681008854 Spore germination protein; Region: Spore_permease; cl15802 288681008855 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681008856 Tubulin like; Region: Tubulin_2; pfam13809 288681008857 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 288681008858 metal ion-dependent adhesion site (MIDAS); other site 288681008859 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008860 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681008861 active site 288681008862 metal binding site [ion binding]; metal-binding site 288681008863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681008864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008865 S-adenosylmethionine binding site [chemical binding]; other site 288681008866 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681008867 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681008868 peptide binding site [polypeptide binding]; other site 288681008869 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681008870 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681008871 peptide binding site [polypeptide binding]; other site 288681008872 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681008873 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681008874 peptide binding site [polypeptide binding]; other site 288681008875 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681008876 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681008877 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 288681008878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681008879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681008880 DNA binding residues [nucleotide binding] 288681008881 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681008882 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681008883 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681008884 Walker A/P-loop; other site 288681008885 ATP binding site [chemical binding]; other site 288681008886 Q-loop/lid; other site 288681008887 ABC transporter signature motif; other site 288681008888 Walker B; other site 288681008889 D-loop; other site 288681008890 H-loop/switch region; other site 288681008891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008892 Helix-turn-helix domains; Region: HTH; cl00088 288681008893 putative oxidoreductase; Provisional; Region: PRK11579 288681008894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008895 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681008896 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 288681008897 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 288681008898 CAP-like domain; other site 288681008899 active site 288681008900 primary dimer interface [polypeptide binding]; other site 288681008901 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681008902 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681008903 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681008904 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681008905 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 288681008906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008907 ATP binding site [chemical binding]; other site 288681008908 Mg2+ binding site [ion binding]; other site 288681008909 G-X-G motif; other site 288681008910 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288681008911 anchoring element; other site 288681008912 dimer interface [polypeptide binding]; other site 288681008913 ATP binding site [chemical binding]; other site 288681008914 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 288681008915 active site 288681008916 putative metal-binding site [ion binding]; other site 288681008917 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288681008918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008919 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288681008920 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681008921 protein binding site [polypeptide binding]; other site 288681008922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681008923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008924 active site 288681008925 phosphorylation site [posttranslational modification] 288681008926 intermolecular recognition site; other site 288681008927 dimerization interface [polypeptide binding]; other site 288681008928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681008929 DNA binding site [nucleotide binding] 288681008930 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 288681008931 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 288681008932 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 288681008933 Class III ribonucleotide reductase; Region: RNR_III; cd01675 288681008934 effector binding site; other site 288681008935 active site 288681008936 Zn binding site [ion binding]; other site 288681008937 glycine loop; other site 288681008938 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 288681008939 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 288681008940 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681008941 active site 288681008942 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 288681008943 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681008944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681008945 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 288681008946 active site 288681008947 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 288681008948 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 288681008949 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681008950 active site 288681008951 catalytic site [active] 288681008952 substrate binding site [chemical binding]; other site 288681008953 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681008954 catalytic residues [active] 288681008955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681008956 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681008957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681008958 Walker A/P-loop; other site 288681008959 ATP binding site [chemical binding]; other site 288681008960 Q-loop/lid; other site 288681008961 ABC transporter signature motif; other site 288681008962 Walker B; other site 288681008963 D-loop; other site 288681008964 H-loop/switch region; other site 288681008965 aconitate hydratase; Validated; Region: PRK09277 288681008966 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 288681008967 substrate binding site [chemical binding]; other site 288681008968 ligand binding site [chemical binding]; other site 288681008969 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 288681008970 substrate binding site [chemical binding]; other site 288681008971 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 288681008972 NodB motif; other site 288681008973 active site 288681008974 catalytic site [active] 288681008975 metal binding site [ion binding]; metal-binding site 288681008976 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681008977 putative dimer interface [polypeptide binding]; other site 288681008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008980 putative substrate translocation pore; other site 288681008981 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 288681008982 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 288681008983 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681008984 nudix motif; other site 288681008985 SAP domain; Region: SAP; cl02640 288681008986 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 288681008987 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681008988 dimer interface [polypeptide binding]; other site 288681008989 active site 288681008990 acyl-CoA synthetase; Validated; Region: PRK07638 288681008991 AMP-binding enzyme; Region: AMP-binding; cl15778 288681008992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008993 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681008994 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681008995 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 288681008996 AMP-binding enzyme; Region: AMP-binding; cl15778 288681008997 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681008998 S-layer homology domain; Region: SLH; pfam00395 288681008999 S-layer homology domain; Region: SLH; pfam00395 288681009000 S-layer homology domain; Region: SLH; pfam00395 288681009001 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681009002 active site 288681009003 catalytic motif [active] 288681009004 Zn binding site [ion binding]; other site 288681009005 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 288681009006 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009007 amidase catalytic site [active] 288681009008 Zn binding residues [ion binding]; other site 288681009009 substrate binding site [chemical binding]; other site 288681009010 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681009011 active site 288681009012 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681009013 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681009014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009015 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 288681009016 dimer interface [polypeptide binding]; other site 288681009017 putative metal binding site [ion binding]; other site 288681009018 PAS domain S-box; Region: sensory_box; TIGR00229 288681009019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681009020 putative active site [active] 288681009021 heme pocket [chemical binding]; other site 288681009022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681009023 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 288681009024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 288681009025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681009026 ATP binding site [chemical binding]; other site 288681009027 Mg2+ binding site [ion binding]; other site 288681009028 G-X-G motif; other site 288681009029 Predicted esterase [General function prediction only]; Region: COG0400 288681009030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681009031 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681009032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009033 Zn binding site [ion binding]; other site 288681009034 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681009035 Zn binding site [ion binding]; other site 288681009036 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681009037 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 288681009038 Na binding site [ion binding]; other site 288681009039 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 288681009040 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 288681009041 active site 288681009042 FMN binding site [chemical binding]; other site 288681009043 substrate binding site [chemical binding]; other site 288681009044 3Fe-4S cluster binding site [ion binding]; other site 288681009045 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 288681009046 FMN binding site [chemical binding]; other site 288681009047 active site 288681009048 substrate binding site [chemical binding]; other site 288681009049 catalytic residue [active] 288681009050 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 288681009051 Arginase family; Region: Arginase; cl00306 288681009052 imidazolonepropionase; Validated; Region: PRK09356 288681009053 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 288681009054 active site 288681009055 urocanate hydratase; Provisional; Region: PRK05414 288681009056 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 288681009057 active sites [active] 288681009058 tetramer interface [polypeptide binding]; other site 288681009059 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 288681009060 hexamer interface [polypeptide binding]; other site 288681009061 RNA binding site [nucleotide binding]; other site 288681009062 Histidine-zinc binding site [chemical binding]; other site 288681009063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681009064 S-adenosylmethionine binding site [chemical binding]; other site 288681009065 DJ-1 family protein; Region: not_thiJ; TIGR01383 288681009066 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681009067 conserved cys residue [active] 288681009068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009069 active site 288681009070 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 288681009071 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009072 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009073 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009074 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009075 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009076 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009077 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009078 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009079 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009080 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009081 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009082 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009083 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009084 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009085 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009086 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009087 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009088 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009089 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681009090 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 288681009091 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 288681009092 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681009093 EamA-like transporter family; Region: EamA; cl01037 288681009094 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 288681009095 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 288681009096 metal binding site [ion binding]; metal-binding site 288681009097 dimer interface [polypeptide binding]; other site 288681009098 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681009099 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681009100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009101 Walker A/P-loop; other site 288681009102 ATP binding site [chemical binding]; other site 288681009103 Q-loop/lid; other site 288681009104 ABC transporter signature motif; other site 288681009105 Walker B; other site 288681009106 D-loop; other site 288681009107 H-loop/switch region; other site 288681009108 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 288681009109 Helix-turn-helix domains; Region: HTH; cl00088 288681009110 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 288681009111 putative dimerization interface [polypeptide binding]; other site 288681009112 putative substrate binding pocket [chemical binding]; other site 288681009113 LrgA family; Region: LrgA; cl00608 288681009114 LrgB-like family; Region: LrgB; cl00596 288681009115 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681009116 nudix motif; other site 288681009117 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 288681009118 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681009119 S-layer homology domain; Region: SLH; pfam00395 288681009120 S-layer homology domain; Region: SLH; pfam00395 288681009121 S-layer homology domain; Region: SLH; pfam00395 288681009122 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009123 amidase catalytic site [active] 288681009124 Zn binding residues [ion binding]; other site 288681009125 substrate binding site [chemical binding]; other site 288681009126 Restriction endonuclease; Region: Mrr_cat; cl00516 288681009127 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 288681009128 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681009129 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 288681009130 Walker A/P-loop; other site 288681009131 ATP binding site [chemical binding]; other site 288681009132 Q-loop/lid; other site 288681009133 ABC transporter signature motif; other site 288681009134 Walker B; other site 288681009135 D-loop; other site 288681009136 H-loop/switch region; other site 288681009137 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681009138 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 288681009139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009140 Walker A/P-loop; other site 288681009141 ATP binding site [chemical binding]; other site 288681009142 Q-loop/lid; other site 288681009143 ABC transporter signature motif; other site 288681009144 Walker B; other site 288681009145 D-loop; other site 288681009146 H-loop/switch region; other site 288681009147 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 288681009148 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 288681009149 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 288681009150 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 288681009151 TPP-binding site [chemical binding]; other site 288681009152 dimer interface [polypeptide binding]; other site 288681009153 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681009154 PYR/PP interface [polypeptide binding]; other site 288681009155 dimer interface [polypeptide binding]; other site 288681009156 TPP binding site [chemical binding]; other site 288681009157 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681009158 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288681009159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681009160 dimer interface [polypeptide binding]; other site 288681009161 conserved gate region; other site 288681009162 ABC-ATPase subunit interface; other site 288681009163 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288681009164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681009165 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 288681009166 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 288681009167 Walker A/P-loop; other site 288681009168 ATP binding site [chemical binding]; other site 288681009169 Q-loop/lid; other site 288681009170 ABC transporter signature motif; other site 288681009171 Walker B; other site 288681009172 D-loop; other site 288681009173 H-loop/switch region; other site 288681009174 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 288681009175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681009176 membrane-bound complex binding site; other site 288681009177 hinge residues; other site 288681009178 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681009179 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681009180 active site 288681009181 metal binding site [ion binding]; metal-binding site 288681009182 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681009183 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 288681009184 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681009185 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 288681009186 catalytic residues [active] 288681009187 catalytic nucleophile [active] 288681009188 LexA repressor; Validated; Region: PRK00215 288681009189 Helix-turn-helix domains; Region: HTH; cl00088 288681009190 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 288681009191 Catalytic site [active] 288681009192 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681009193 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681009194 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 288681009195 Helix-turn-helix domains; Region: HTH; cl00088 288681009196 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681009197 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 288681009198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681009199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009200 Walker A/P-loop; other site 288681009201 ATP binding site [chemical binding]; other site 288681009202 Q-loop/lid; other site 288681009203 AAA domain; Region: AAA_21; pfam13304 288681009204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009205 ABC transporter signature motif; other site 288681009206 Walker B; other site 288681009207 D-loop; other site 288681009208 H-loop/switch region; other site 288681009209 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009210 amidase catalytic site [active] 288681009211 Zn binding residues [ion binding]; other site 288681009212 substrate binding site [chemical binding]; other site 288681009213 Bacterial SH3 domain; Region: SH3_3; cl02551 288681009214 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 288681009215 Haemolysin XhlA; Region: XhlA; pfam10779 288681009216 prophage LambdaBa01 288681009217 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681009218 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 288681009219 Phage-related protein [Function unknown]; Region: COG4722; cl15832 288681009220 Phage tail protein; Region: Sipho_tail; pfam05709 288681009221 Phage-related protein [Function unknown]; Region: COG5412 288681009222 membrane protein P6; Region: PHA01399 288681009223 prophage LambdaBa04 fragment 288681009224 Phage-related minor tail protein [Function unknown]; Region: COG5280 288681009225 prophage pi2 fragment 288681009226 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 288681009227 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 288681009228 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 288681009229 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 288681009230 Phage capsid family; Region: Phage_capsid; pfam05065 288681009231 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 288681009232 Phage-related protein [Function unknown]; Region: COG4695; cl01923 288681009233 Phage portal protein; Region: Phage_portal; pfam04860 288681009234 Phage Terminase; Region: Terminase_1; pfam03354 288681009235 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 288681009236 GIY-YIG motif/motif A; other site 288681009237 putative active site [active] 288681009238 catalytic site [active] 288681009239 putative metal binding site [ion binding]; other site 288681009240 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912 288681009241 Phage Terminase; Region: Terminase_1; pfam03354 288681009242 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 288681009243 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 288681009244 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681009245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 288681009246 Protein of unknown function DUF262; Region: DUF262; cl14890 288681009247 Protein of unknown function DUF262; Region: DUF262; cl14890 288681009248 Protein of unknown function DUF262; Region: DUF262; cl14890 288681009249 HNH endonuclease; Region: HNH_5; pfam14279 288681009250 positive control sigma-like factor; Validated; Region: PRK06930 288681009251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681009252 DNA binding residues [nucleotide binding] 288681009253 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 288681009254 TPR repeat; Region: TPR_11; pfam13414 288681009255 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681009256 Restriction endonuclease; Region: Mrr_cat; cl00516 288681009257 Thymidylate synthase complementing protein; Region: Thy1; cl03630 288681009258 dUTPase; Region: dUTPase_2; pfam08761 288681009259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681009260 active site 288681009261 homodimer interface [polypeptide binding]; other site 288681009262 metal binding site [ion binding]; metal-binding site 288681009263 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 288681009264 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713 288681009265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009266 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681009267 Walker A motif; other site 288681009268 ATP binding site [chemical binding]; other site 288681009269 Walker B motif; other site 288681009270 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 288681009271 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 288681009272 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 288681009273 Domain of unknown function (DUF771); Region: DUF771; cl09962 288681009274 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 288681009275 ORF6C domain; Region: ORF6C; pfam10552 288681009276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681009277 sequence-specific DNA binding site [nucleotide binding]; other site 288681009278 salt bridge; other site 288681009279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681009280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681009281 non-specific DNA binding site [nucleotide binding]; other site 288681009282 salt bridge; other site 288681009283 sequence-specific DNA binding site [nucleotide binding]; other site 288681009284 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 288681009285 Domain of unknown function (DUF955); Region: DUF955; cl01076 288681009286 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 288681009287 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 288681009288 Int/Topo IB signature motif; other site 288681009289 glutamine synthetase, type I; Region: GlnA; TIGR00653 288681009290 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 288681009291 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 288681009292 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 288681009293 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681009294 DNA binding residues [nucleotide binding] 288681009295 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 288681009296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681009297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681009298 catalytic residue [active] 288681009299 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 288681009300 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 288681009301 HflX GTPase family; Region: HflX; cd01878 288681009302 G1 box; other site 288681009303 GTP/Mg2+ binding site [chemical binding]; other site 288681009304 Switch I region; other site 288681009305 G2 box; other site 288681009306 G3 box; other site 288681009307 Switch II region; other site 288681009308 G4 box; other site 288681009309 G5 box; other site 288681009310 Predicted membrane protein [Function unknown]; Region: COG2860 288681009311 UPF0126 domain; Region: UPF0126; pfam03458 288681009312 UPF0126 domain; Region: UPF0126; pfam03458 288681009313 stage V sporulation protein K; Region: spore_V_K; TIGR02881 288681009314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009315 Walker A motif; other site 288681009316 ATP binding site [chemical binding]; other site 288681009317 Walker B motif; other site 288681009318 arginine finger; other site 288681009319 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 288681009320 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681009321 active site 288681009322 catalytic residues [active] 288681009323 DNA binding site [nucleotide binding] 288681009324 Int/Topo IB signature motif; other site 288681009325 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 288681009326 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 288681009327 Sm1 motif; other site 288681009328 intra - hexamer interaction site; other site 288681009329 inter - hexamer interaction site [polypeptide binding]; other site 288681009330 nucleotide binding pocket [chemical binding]; other site 288681009331 Sm2 motif; other site 288681009332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009333 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 288681009334 Bacterial SH3 domain; Region: SH3_3; cl02551 288681009335 Bacterial SH3 domain; Region: SH3_3; cl02551 288681009336 3D domain; Region: 3D; cl01439 288681009337 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 288681009338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681009339 active site 288681009340 phosphorylation site [posttranslational modification] 288681009341 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 288681009342 active site 288681009343 P-loop; other site 288681009344 phosphorylation site [posttranslational modification] 288681009345 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681009346 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 288681009347 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288681009348 putative substrate binding site [chemical binding]; other site 288681009349 putative ATP binding site [chemical binding]; other site 288681009350 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681009351 Helix-turn-helix domains; Region: HTH; cl00088 288681009352 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681009353 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 288681009354 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 288681009355 dimer interface [polypeptide binding]; other site 288681009356 active site 288681009357 metal binding site [ion binding]; metal-binding site 288681009358 Protein of unknown function (DUF420); Region: DUF420; cl00989 288681009359 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 288681009360 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 288681009361 Glyco_18 domain; Region: Glyco_18; smart00636 288681009362 putative active site [active] 288681009363 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 288681009364 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681009365 putative active site [active] 288681009366 putative metal binding site [ion binding]; other site 288681009367 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 288681009368 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 288681009369 IHF dimer interface [polypeptide binding]; other site 288681009370 IHF - DNA interface [nucleotide binding]; other site 288681009371 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009372 metal-binding site [ion binding] 288681009373 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288681009374 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009375 metal-binding site [ion binding] 288681009376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681009377 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681009378 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009379 metal-binding site [ion binding] 288681009380 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 288681009381 putative homodimer interface [polypeptide binding]; other site 288681009382 putative homotetramer interface [polypeptide binding]; other site 288681009383 putative allosteric switch controlling residues; other site 288681009384 putative metal binding site [ion binding]; other site 288681009385 putative homodimer-homodimer interface [polypeptide binding]; other site 288681009386 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681009387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681009388 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681009389 Walker A/P-loop; other site 288681009390 ATP binding site [chemical binding]; other site 288681009391 Q-loop/lid; other site 288681009392 ABC transporter signature motif; other site 288681009393 Walker B; other site 288681009394 D-loop; other site 288681009395 H-loop/switch region; other site 288681009396 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681009397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009398 ABC-ATPase subunit interface; other site 288681009399 dimer interface [polypeptide binding]; other site 288681009400 putative PBP binding regions; other site 288681009401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009402 ABC-ATPase subunit interface; other site 288681009403 dimer interface [polypeptide binding]; other site 288681009404 putative PBP binding regions; other site 288681009405 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681009406 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681009407 putative ligand binding residues [chemical binding]; other site 288681009408 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 288681009409 active site 288681009410 putative catalytic site [active] 288681009411 DNA binding site [nucleotide binding] 288681009412 putative phosphate binding site [ion binding]; other site 288681009413 metal binding site A [ion binding]; metal-binding site 288681009414 AP binding site [nucleotide binding]; other site 288681009415 metal binding site B [ion binding]; metal-binding site 288681009416 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 288681009417 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 288681009418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681009419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681009420 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 288681009421 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288681009422 DNA binding site [nucleotide binding] 288681009423 active site 288681009424 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 288681009425 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 288681009426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681009427 minor groove reading motif; other site 288681009428 helix-hairpin-helix signature motif; other site 288681009429 substrate binding pocket [chemical binding]; other site 288681009430 active site 288681009431 peptidase T; Region: peptidase-T; TIGR01882 288681009432 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 288681009433 metal binding site [ion binding]; metal-binding site 288681009434 dimer interface [polypeptide binding]; other site 288681009435 Predicted membrane protein [Function unknown]; Region: COG2364 288681009436 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681009437 hypothetical protein; Provisional; Region: PRK06764 288681009438 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681009439 catalytic core [active] 288681009440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681009441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681009443 active site 288681009444 metal binding site [ion binding]; metal-binding site 288681009445 PAS domain S-box; Region: sensory_box; TIGR00229 288681009446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681009447 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681009448 metal binding site [ion binding]; metal-binding site 288681009449 active site 288681009450 I-site; other site 288681009451 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681009452 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 288681009453 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 288681009454 LrgA family; Region: LrgA; cl00608 288681009455 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681009456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681009457 DNA-binding site [nucleotide binding]; DNA binding site 288681009458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681009459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681009460 homodimer interface [polypeptide binding]; other site 288681009461 catalytic residue [active] 288681009462 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 288681009463 active site 288681009464 catalytic site [active] 288681009465 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 288681009466 putative active site [active] 288681009467 putative catalytic triad [active] 288681009468 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681009469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009470 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 288681009471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009472 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681009473 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 288681009474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009475 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681009476 Sulfatase; Region: Sulfatase; cl10460 288681009477 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 288681009478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681009479 binding surface 288681009480 TPR motif; other site 288681009481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009482 G1 box; other site 288681009483 GTP/Mg2+ binding site [chemical binding]; other site 288681009484 Switch I region; other site 288681009485 G3 box; other site 288681009486 Switch II region; other site 288681009487 G4 box; other site 288681009488 G5 box; other site 288681009489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681009490 dimerization interface [polypeptide binding]; other site 288681009491 putative DNA binding site [nucleotide binding]; other site 288681009492 putative Zn2+ binding site [ion binding]; other site 288681009493 hypothetical protein; Validated; Region: PRK08223 288681009494 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 288681009495 ATP binding site [chemical binding]; other site 288681009496 substrate interface [chemical binding]; other site 288681009497 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 288681009498 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 288681009499 substrate binding site [chemical binding]; other site 288681009500 active site 288681009501 cosubstrate binding site; other site 288681009502 catalytic site [active] 288681009503 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 288681009504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681009506 putative substrate translocation pore; other site 288681009507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009508 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 288681009509 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681009510 tetramer interface [polypeptide binding]; other site 288681009511 active site 288681009512 Mg2+/Mn2+ binding site [ion binding]; other site 288681009513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681009514 putative DNA binding site [nucleotide binding]; other site 288681009515 putative Zn2+ binding site [ion binding]; other site 288681009516 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 288681009517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681009518 ATP binding site [chemical binding]; other site 288681009519 Mg2+ binding site [ion binding]; other site 288681009520 G-X-G motif; other site 288681009521 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 288681009522 ATP binding site [chemical binding]; other site 288681009523 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 288681009524 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 288681009525 MutS domain I; Region: MutS_I; pfam01624 288681009526 MutS domain II; Region: MutS_II; pfam05188 288681009527 MutS family domain IV; Region: MutS_IV; pfam05190 288681009528 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 288681009529 Walker A/P-loop; other site 288681009530 ATP binding site [chemical binding]; other site 288681009531 Q-loop/lid; other site 288681009532 ABC transporter signature motif; other site 288681009533 Walker B; other site 288681009534 D-loop; other site 288681009535 H-loop/switch region; other site 288681009536 Outer spore coat protein E (CotE); Region: CotE; pfam10628 288681009537 Protein of unknown function (DUF964); Region: DUF964; cl01483 288681009538 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 288681009539 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 288681009540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681009541 FeS/SAM binding site; other site 288681009542 TRAM domain; Region: TRAM; cl01282 288681009543 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 288681009544 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 288681009545 TPP-binding site [chemical binding]; other site 288681009546 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 288681009547 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 288681009548 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 288681009549 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 288681009550 dimer interface [polypeptide binding]; other site 288681009551 PYR/PP interface [polypeptide binding]; other site 288681009552 TPP binding site [chemical binding]; other site 288681009553 substrate binding site [chemical binding]; other site 288681009554 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681009555 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 288681009556 active site 288681009557 dimer interface [polypeptide binding]; other site 288681009558 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 288681009559 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 288681009560 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681009561 putative active site [active] 288681009562 metal binding site [ion binding]; metal-binding site 288681009563 homodimer binding site [polypeptide binding]; other site 288681009564 phosphodiesterase; Provisional; Region: PRK12704 288681009565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681009566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009568 Walker A motif; other site 288681009569 ATP binding site [chemical binding]; other site 288681009570 Walker B motif; other site 288681009571 competence damage-inducible protein A; Provisional; Region: PRK00549 288681009572 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 288681009573 putative MPT binding site; other site 288681009574 Competence-damaged protein; Region: CinA; cl00666 288681009575 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 288681009576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681009577 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 288681009578 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 288681009579 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 288681009580 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 288681009581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 288681009582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009583 NAD(P) binding site [chemical binding]; other site 288681009584 active site 288681009585 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681009586 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 288681009587 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681009588 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681009589 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681009590 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288681009591 TM-ABC transporter signature motif; other site 288681009592 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288681009593 TM-ABC transporter signature motif; other site 288681009594 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 288681009595 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 288681009596 Walker A/P-loop; other site 288681009597 ATP binding site [chemical binding]; other site 288681009598 Q-loop/lid; other site 288681009599 ABC transporter signature motif; other site 288681009600 Walker B; other site 288681009601 D-loop; other site 288681009602 H-loop/switch region; other site 288681009603 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 288681009604 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 288681009605 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 288681009606 ligand binding site [chemical binding]; other site 288681009607 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681009608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681009609 DNA-binding site [nucleotide binding]; DNA binding site 288681009610 UTRA domain; Region: UTRA; cl01230 288681009611 Tetraspanin family; Region: Tetraspannin; pfam00335 288681009612 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 288681009613 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009614 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 288681009615 YlzJ-like protein; Region: YlzJ; pfam14035 288681009616 Clp protease; Region: CLP_protease; pfam00574 288681009617 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 288681009618 active site 288681009619 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681009620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681009621 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681009622 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 288681009623 dihydrodipicolinate synthase; Region: dapA; TIGR00674 288681009624 dimer interface [polypeptide binding]; other site 288681009625 active site 288681009626 catalytic residue [active] 288681009627 aspartate kinase I; Reviewed; Region: PRK08210 288681009628 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 288681009629 nucleotide binding site [chemical binding]; other site 288681009630 substrate binding site [chemical binding]; other site 288681009631 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 288681009632 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 288681009633 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 288681009634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009635 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 288681009636 Flavoprotein; Region: Flavoprotein; cl08021 288681009637 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 288681009638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009639 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 288681009640 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681009641 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 288681009642 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681009643 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 288681009644 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 288681009645 NodB motif; other site 288681009646 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 288681009647 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 288681009648 RNase E interface [polypeptide binding]; other site 288681009649 trimer interface [polypeptide binding]; other site 288681009650 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 288681009651 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 288681009652 RNase E interface [polypeptide binding]; other site 288681009653 trimer interface [polypeptide binding]; other site 288681009654 active site 288681009655 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 288681009656 putative nucleic acid binding region [nucleotide binding]; other site 288681009657 G-X-X-G motif; other site 288681009658 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 288681009659 RNA binding site [nucleotide binding]; other site 288681009660 domain interface; other site 288681009661 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 288681009662 16S/18S rRNA binding site [nucleotide binding]; other site 288681009663 S13e-L30e interaction site [polypeptide binding]; other site 288681009664 25S rRNA binding site [nucleotide binding]; other site 288681009665 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 288681009666 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 288681009667 active site 288681009668 Riboflavin kinase; Region: Flavokinase; cl03312 288681009669 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 288681009670 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 288681009671 RNA binding site [nucleotide binding]; other site 288681009672 active site 288681009673 Ribosome-binding factor A; Region: RBFA; cl00542 288681009674 Protein of unknown function (DUF503); Region: DUF503; cl00669 288681009675 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288681009676 translation initiation factor IF-2; Region: IF-2; TIGR00487 288681009677 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288681009678 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 288681009679 G1 box; other site 288681009680 putative GEF interaction site [polypeptide binding]; other site 288681009681 GTP/Mg2+ binding site [chemical binding]; other site 288681009682 Switch I region; other site 288681009683 G2 box; other site 288681009684 G3 box; other site 288681009685 Switch II region; other site 288681009686 G4 box; other site 288681009687 G5 box; other site 288681009688 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 288681009689 Translation-initiation factor 2; Region: IF-2; pfam11987 288681009690 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 288681009691 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 288681009692 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 288681009693 putative RNA binding cleft [nucleotide binding]; other site 288681009694 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 288681009695 NusA N-terminal domain; Region: NusA_N; pfam08529 288681009696 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 288681009697 RNA binding site [nucleotide binding]; other site 288681009698 homodimer interface [polypeptide binding]; other site 288681009699 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 288681009700 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 288681009701 G-X-X-G motif; other site 288681009702 ribosome maturation protein RimP; Reviewed; Region: PRK00092 288681009703 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 288681009704 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 288681009705 Sm1 motif; other site 288681009706 predicted subunit interaction site [polypeptide binding]; other site 288681009707 RNA binding pocket [nucleotide binding]; other site 288681009708 Sm2 motif; other site 288681009709 DNA polymerase III PolC; Validated; Region: polC; PRK00448 288681009710 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 288681009711 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 288681009712 generic binding surface II; other site 288681009713 generic binding surface I; other site 288681009714 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681009715 active site 288681009716 catalytic site [active] 288681009717 substrate binding site [chemical binding]; other site 288681009718 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 288681009719 prolyl-tRNA synthetase; Provisional; Region: PRK09194 288681009720 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 288681009721 dimer interface [polypeptide binding]; other site 288681009722 motif 1; other site 288681009723 active site 288681009724 motif 2; other site 288681009725 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 288681009726 putative deacylase active site [active] 288681009727 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 288681009728 active site 288681009729 motif 3; other site 288681009730 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 288681009731 anticodon binding site; other site 288681009732 RIP metalloprotease RseP; Region: TIGR00054 288681009733 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 288681009734 active site 288681009735 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 288681009736 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288681009737 protein binding site [polypeptide binding]; other site 288681009738 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 288681009739 putative substrate binding region [chemical binding]; other site 288681009740 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 288681009741 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 288681009742 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 288681009743 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 288681009744 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 288681009745 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 288681009746 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 288681009747 catalytic residue [active] 288681009748 putative FPP diphosphate binding site; other site 288681009749 putative FPP binding hydrophobic cleft; other site 288681009750 dimer interface [polypeptide binding]; other site 288681009751 putative IPP diphosphate binding site; other site 288681009752 ribosome recycling factor; Reviewed; Region: frr; PRK00083 288681009753 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 288681009754 hinge region; other site 288681009755 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 288681009756 putative nucleotide binding site [chemical binding]; other site 288681009757 uridine monophosphate binding site [chemical binding]; other site 288681009758 homohexameric interface [polypeptide binding]; other site 288681009759 elongation factor Ts; Provisional; Region: tsf; PRK09377 288681009760 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 288681009761 Elongation factor TS; Region: EF_TS; pfam00889 288681009762 Elongation factor TS; Region: EF_TS; pfam00889 288681009763 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 288681009764 rRNA interaction site [nucleotide binding]; other site 288681009765 S8 interaction site; other site 288681009766 putative laminin-1 binding site; other site 288681009767 transcriptional repressor CodY; Validated; Region: PRK04158 288681009768 CodY GAF-like domain; Region: CodY; pfam06018 288681009769 Helix-turn-helix domains; Region: HTH; cl00088 288681009770 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 288681009771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009772 Walker A motif; other site 288681009773 ATP binding site [chemical binding]; other site 288681009774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009775 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 288681009776 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 288681009777 active site 288681009778 HslU subunit interaction site [polypeptide binding]; other site 288681009779 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 288681009780 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 288681009781 active site 288681009782 Int/Topo IB signature motif; other site 288681009783 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 288681009784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009785 DNA topoisomerase I; Validated; Region: PRK05582 288681009786 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 288681009787 active site 288681009788 interdomain interaction site; other site 288681009789 putative metal-binding site [ion binding]; other site 288681009790 nucleotide binding site [chemical binding]; other site 288681009791 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681009792 domain I; other site 288681009793 DNA binding groove [nucleotide binding] 288681009794 phosphate binding site [ion binding]; other site 288681009795 domain II; other site 288681009796 domain III; other site 288681009797 nucleotide binding site [chemical binding]; other site 288681009798 catalytic site [active] 288681009799 domain IV; other site 288681009800 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681009801 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681009802 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 288681009803 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 288681009804 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 288681009805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681009806 CoA-ligase; Region: Ligase_CoA; cl02894 288681009807 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 288681009808 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681009809 CoA-ligase; Region: Ligase_CoA; cl02894 288681009810 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 288681009811 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681009812 active site 288681009813 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 288681009814 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 288681009815 GTP/Mg2+ binding site [chemical binding]; other site 288681009816 G4 box; other site 288681009817 G5 box; other site 288681009818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009819 G1 box; other site 288681009820 G1 box; other site 288681009821 GTP/Mg2+ binding site [chemical binding]; other site 288681009822 Switch I region; other site 288681009823 G2 box; other site 288681009824 G2 box; other site 288681009825 G3 box; other site 288681009826 G3 box; other site 288681009827 Switch II region; other site 288681009828 Switch II region; other site 288681009829 G4 box; other site 288681009830 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681009831 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681009832 Catalytic site [active] 288681009833 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681009834 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 288681009835 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 288681009836 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 288681009837 RimM N-terminal domain; Region: RimM; pfam01782 288681009838 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 288681009839 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 288681009840 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 288681009841 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 288681009842 signal recognition particle protein; Provisional; Region: PRK10867 288681009843 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 288681009844 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 288681009845 P loop; other site 288681009846 GTP binding site [chemical binding]; other site 288681009847 Signal peptide binding domain; Region: SRP_SPB; pfam02978 288681009848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681009849 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 288681009850 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 288681009851 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 288681009852 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 288681009853 P loop; other site 288681009854 GTP binding site [chemical binding]; other site 288681009855 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 288681009856 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 288681009857 Walker A/P-loop; other site 288681009858 ATP binding site [chemical binding]; other site 288681009859 Q-loop/lid; other site 288681009860 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 288681009861 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 288681009862 ABC transporter signature motif; other site 288681009863 Walker B; other site 288681009864 D-loop; other site 288681009865 H-loop/switch region; other site 288681009866 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 288681009867 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 288681009868 dimerization interface [polypeptide binding]; other site 288681009869 active site 288681009870 metal binding site [ion binding]; metal-binding site 288681009871 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 288681009872 dsRNA binding site [nucleotide binding]; other site 288681009873 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681009874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288681009875 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288681009876 NAD(P) binding site [chemical binding]; other site 288681009877 homotetramer interface [polypeptide binding]; other site 288681009878 homodimer interface [polypeptide binding]; other site 288681009879 active site 288681009880 Acyl transferase domain; Region: Acyl_transf_1; cl08282 288681009881 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 288681009882 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 288681009883 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 288681009884 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288681009885 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 288681009886 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 288681009887 generic binding surface II; other site 288681009888 ssDNA binding site; other site 288681009889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681009890 ATP binding site [chemical binding]; other site 288681009891 putative Mg++ binding site [ion binding]; other site 288681009892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681009893 nucleotide binding region [chemical binding]; other site 288681009894 ATP-binding site [chemical binding]; other site 288681009895 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 288681009896 DAK2 domain; Region: Dak2; cl03685 288681009897 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 288681009898 Asp23 family; Region: Asp23; cl00574 288681009899 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 288681009900 Thiamine pyrophosphokinase; Region: TPK; cd07995 288681009901 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 288681009902 active site 288681009903 dimerization interface [polypeptide binding]; other site 288681009904 thiamine binding site [chemical binding]; other site 288681009905 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 288681009906 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 288681009907 substrate binding site [chemical binding]; other site 288681009908 hexamer interface [polypeptide binding]; other site 288681009909 metal binding site [ion binding]; metal-binding site 288681009910 GTPase RsgA; Reviewed; Region: PRK00098 288681009911 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 288681009912 RNA binding site [nucleotide binding]; other site 288681009913 homodimer interface [polypeptide binding]; other site 288681009914 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 288681009915 GTPase/Zn-binding domain interface [polypeptide binding]; other site 288681009916 GTP/Mg2+ binding site [chemical binding]; other site 288681009917 G4 box; other site 288681009918 G5 box; other site 288681009919 G1 box; other site 288681009920 Switch I region; other site 288681009921 G2 box; other site 288681009922 G3 box; other site 288681009923 Switch II region; other site 288681009924 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288681009925 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288681009926 active site 288681009927 ATP binding site [chemical binding]; other site 288681009928 substrate binding site [chemical binding]; other site 288681009929 activation loop (A-loop); other site 288681009930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 288681009931 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288681009932 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 288681009933 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288681009934 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 288681009935 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 288681009936 active site 288681009937 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 288681009938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681009939 FeS/SAM binding site; other site 288681009940 16S rRNA methyltransferase B; Provisional; Region: PRK14902 288681009941 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 288681009942 putative RNA binding site [nucleotide binding]; other site 288681009943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681009944 S-adenosylmethionine binding site [chemical binding]; other site 288681009945 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 288681009946 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 288681009947 putative active site [active] 288681009948 substrate binding site [chemical binding]; other site 288681009949 putative cosubstrate binding site; other site 288681009950 catalytic site [active] 288681009951 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 288681009952 substrate binding site [chemical binding]; other site 288681009953 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288681009954 active site 288681009955 catalytic residues [active] 288681009956 metal binding site [ion binding]; metal-binding site 288681009957 primosome assembly protein PriA; Validated; Region: PRK05580 288681009958 primosome assembly protein PriA; Validated; Region: PRK05580 288681009959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681009960 ATP binding site [chemical binding]; other site 288681009961 putative Mg++ binding site [ion binding]; other site 288681009962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681009963 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 288681009964 Flavoprotein; Region: Flavoprotein; cl08021 288681009965 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 288681009966 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 288681009967 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 288681009968 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 288681009969 catalytic site [active] 288681009970 G-X2-G-X-G-K; other site 288681009971 Domain of unknown function (DUF370); Region: DUF370; cl00898 288681009972 hypothetical protein; Provisional; Region: PRK11820 288681009973 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 288681009974 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 288681009975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 288681009976 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 288681009977 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681009978 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 288681009979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681009980 motif II; other site 288681009981 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 288681009982 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 288681009983 Domain of unknown function (DUF814); Region: DUF814; pfam05670 288681009984 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681009985 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681009986 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681009987 active site 288681009988 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681009989 DinB superfamily; Region: DinB_2; pfam12867 288681009990 YoqO-like protein; Region: YoqO; pfam14037 288681009991 YoqO-like protein; Region: YoqO; pfam14037 288681009992 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 288681009993 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 288681009994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681009995 active site 288681009996 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 288681009997 active site 288681009998 dimer interface [polypeptide binding]; other site 288681009999 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 288681010000 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 288681010001 heterodimer interface [polypeptide binding]; other site 288681010002 active site 288681010003 FMN binding site [chemical binding]; other site 288681010004 homodimer interface [polypeptide binding]; other site 288681010005 substrate binding site [chemical binding]; other site 288681010006 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 288681010007 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 288681010008 FAD binding pocket [chemical binding]; other site 288681010009 FAD binding motif [chemical binding]; other site 288681010010 phosphate binding motif [ion binding]; other site 288681010011 beta-alpha-beta structure motif; other site 288681010012 NAD binding pocket [chemical binding]; other site 288681010013 Iron coordination center [ion binding]; other site 288681010014 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 288681010015 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010016 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681010017 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 288681010018 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010019 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681010020 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 288681010021 IMP binding site; other site 288681010022 dimer interface [polypeptide binding]; other site 288681010023 interdomain contacts; other site 288681010024 partial ornithine binding site; other site 288681010025 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 288681010026 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 288681010027 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 288681010028 catalytic site [active] 288681010029 subunit interface [polypeptide binding]; other site 288681010030 dihydroorotase; Validated; Region: pyrC; PRK09357 288681010031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288681010032 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 288681010033 active site 288681010034 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 288681010035 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288681010036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010037 uracil transporter; Provisional; Region: PRK10720 288681010038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681010039 active site 288681010040 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 288681010041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681010042 RNA binding surface [nucleotide binding]; other site 288681010043 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681010044 active site 288681010045 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 288681010046 lipoprotein signal peptidase; Provisional; Region: PRK14787 288681010047 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 288681010048 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 288681010049 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288681010050 active site 288681010051 HIGH motif; other site 288681010052 nucleotide binding site [chemical binding]; other site 288681010053 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288681010054 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681010055 active site 288681010056 KMSKS motif; other site 288681010057 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 288681010058 tRNA binding surface [nucleotide binding]; other site 288681010059 anticodon binding site; other site 288681010060 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288681010061 DivIVA protein; Region: DivIVA; pfam05103 288681010062 DivIVA domain; Region: DivI1A_domain; TIGR03544 288681010063 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 288681010064 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 288681010065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681010066 RNA binding surface [nucleotide binding]; other site 288681010067 YGGT family; Region: YGGT; cl00508 288681010068 Protein of unknown function (DUF552); Region: DUF552; cl00775 288681010069 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 288681010070 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681010071 catalytic residue [active] 288681010072 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 288681010073 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 288681010074 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 288681010075 sporulation sigma factor SigG; Reviewed; Region: PRK08215 288681010076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681010077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681010078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681010079 DNA binding residues [nucleotide binding] 288681010080 sporulation sigma factor SigE; Reviewed; Region: PRK08301 288681010081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681010082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681010083 DNA binding residues [nucleotide binding] 288681010084 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 288681010085 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 288681010086 cell division protein FtsZ; Validated; Region: PRK09330 288681010087 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 288681010088 nucleotide binding site [chemical binding]; other site 288681010089 SulA interaction site; other site 288681010090 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 288681010091 Cell division protein FtsA; Region: FtsA; cl11496 288681010092 Cell division protein FtsA; Region: FtsA; cl11496 288681010093 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 288681010094 Cell division protein FtsQ; Region: FtsQ; pfam03799 288681010095 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 288681010096 FAD binding domain; Region: FAD_binding_4; pfam01565 288681010097 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 288681010098 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 288681010099 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 288681010100 active site 288681010101 homodimer interface [polypeptide binding]; other site 288681010102 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681010103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010104 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 288681010105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681010106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681010107 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 288681010108 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 288681010109 Mg++ binding site [ion binding]; other site 288681010110 putative catalytic motif [active] 288681010111 putative substrate binding site [chemical binding]; other site 288681010112 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 288681010113 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681010114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681010115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681010116 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 288681010117 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681010118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681010119 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 288681010120 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 288681010121 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681010122 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681010123 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 288681010124 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 288681010125 Septum formation initiator; Region: DivIC; cl11433 288681010126 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 288681010127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681010128 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 288681010129 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 288681010130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010131 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 288681010132 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681010133 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681010134 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 288681010135 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 288681010136 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 288681010137 hypothetical protein; Provisional; Region: PRK13670 288681010138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288681010139 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 288681010140 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 288681010141 protein binding site [polypeptide binding]; other site 288681010142 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 288681010143 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 288681010144 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 288681010145 active site 288681010146 nucleophile elbow; other site 288681010147 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 288681010148 Nucleoside recognition; Region: Gate; cl00486 288681010149 Nucleoside recognition; Region: Gate; cl00486 288681010150 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 288681010151 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 288681010152 active site 288681010153 (T/H)XGH motif; other site 288681010154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681010155 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 288681010156 Protein of unknown function (DUF964); Region: DUF964; cl01483 288681010157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681010158 catalytic core [active] 288681010159 YlbE-like protein; Region: YlbE; pfam14003 288681010160 Putative coat protein; Region: YlbD_coat; pfam14071 288681010161 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 288681010162 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 288681010163 YugN-like family; Region: YugN; pfam08868 288681010164 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 288681010165 multimer interface [polypeptide binding]; other site 288681010166 active site 288681010167 catalytic triad [active] 288681010168 dimer interface [polypeptide binding]; other site 288681010169 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 288681010170 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 288681010171 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 288681010172 Subunit I/III interface [polypeptide binding]; other site 288681010173 Subunit III/IV interface [polypeptide binding]; other site 288681010174 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 288681010175 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 288681010176 D-pathway; other site 288681010177 Putative ubiquinol binding site [chemical binding]; other site 288681010178 Low-spin heme (heme b) binding site [chemical binding]; other site 288681010179 Putative water exit pathway; other site 288681010180 Binuclear center (heme o3/CuB) [ion binding]; other site 288681010181 K-pathway; other site 288681010182 Putative proton exit pathway; other site 288681010183 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 288681010184 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 288681010185 Cytochrome c; Region: Cytochrom_C; cl11414 288681010186 UbiA prenyltransferase family; Region: UbiA; cl00337 288681010187 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 288681010188 pyruvate carboxylase; Reviewed; Region: PRK12999 288681010189 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010190 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681010191 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 288681010192 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 288681010193 active site 288681010194 catalytic residues [active] 288681010195 metal binding site [ion binding]; metal-binding site 288681010196 homodimer binding site [polypeptide binding]; other site 288681010197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681010198 carboxyltransferase (CT) interaction site; other site 288681010199 biotinylation site [posttranslational modification]; other site 288681010200 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681010201 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 288681010202 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 288681010203 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 288681010204 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 288681010205 putative active site [active] 288681010206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681010207 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 288681010208 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 288681010209 YlaH-like protein; Region: YlaH; pfam14036 288681010210 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 288681010211 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 288681010212 G1 box; other site 288681010213 putative GEF interaction site [polypeptide binding]; other site 288681010214 GTP/Mg2+ binding site [chemical binding]; other site 288681010215 Switch I region; other site 288681010216 G2 box; other site 288681010217 G3 box; other site 288681010218 Switch II region; other site 288681010219 G4 box; other site 288681010220 G5 box; other site 288681010221 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 288681010222 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 288681010223 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 288681010224 active site 288681010225 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 288681010226 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 288681010227 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 288681010228 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 288681010229 homodimer interface [polypeptide binding]; other site 288681010230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010231 catalytic residue [active] 288681010232 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 288681010233 transglutaminase; Provisional; Region: tgl; PRK03187 288681010234 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 288681010235 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 288681010236 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 288681010237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681010238 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681010239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681010240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681010241 E3 interaction surface; other site 288681010242 lipoyl attachment site [posttranslational modification]; other site 288681010243 e3 binding domain; Region: E3_binding; pfam02817 288681010244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 288681010245 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681010246 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681010247 alpha subunit interface [polypeptide binding]; other site 288681010248 TPP binding site [chemical binding]; other site 288681010249 heterodimer interface [polypeptide binding]; other site 288681010250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681010251 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288681010252 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 288681010253 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288681010254 active site 288681010255 catalytic residues [active] 288681010256 metal binding site [ion binding]; metal-binding site 288681010257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010258 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681010259 active site 288681010260 motif I; other site 288681010261 motif II; other site 288681010262 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681010263 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 288681010264 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681010265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681010266 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681010267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681010268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 288681010270 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681010271 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 288681010272 metal binding site [ion binding]; metal-binding site 288681010273 putative dimer interface [polypeptide binding]; other site 288681010274 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 288681010275 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 288681010276 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 288681010277 trimer interface [polypeptide binding]; other site 288681010278 active site 288681010279 substrate binding site [chemical binding]; other site 288681010280 CoA binding site [chemical binding]; other site 288681010281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681010282 Helix-turn-helix domains; Region: HTH; cl00088 288681010283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681010284 dimerization interface [polypeptide binding]; other site 288681010285 FOG: CBS domain [General function prediction only]; Region: COG0517 288681010286 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 288681010287 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 288681010288 Protein of unknown function (DUF458); Region: DUF458; cl00861 288681010289 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 288681010290 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 288681010291 catalytic residues [active] 288681010292 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 288681010293 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681010294 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 288681010295 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 288681010296 short chain dehydrogenase; Provisional; Region: PRK07677 288681010297 NAD(P) binding site [chemical binding]; other site 288681010298 substrate binding site [chemical binding]; other site 288681010299 homotetramer interface [polypeptide binding]; other site 288681010300 active site 288681010301 homodimer interface [polypeptide binding]; other site 288681010302 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 288681010303 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681010304 putative active site [active] 288681010305 putative metal binding site [ion binding]; other site 288681010306 polyphosphate kinase; Provisional; Region: PRK05443 288681010307 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 288681010308 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 288681010309 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 288681010310 putative domain interface [polypeptide binding]; other site 288681010311 putative active site [active] 288681010312 catalytic site [active] 288681010313 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 288681010314 putative domain interface [polypeptide binding]; other site 288681010315 putative active site [active] 288681010316 catalytic site [active] 288681010317 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 288681010318 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 288681010319 YkyB-like protein; Region: YkyB; pfam14177 288681010320 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 288681010321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681010322 I-site; other site 288681010323 active site 288681010324 metal binding site [ion binding]; metal-binding site 288681010325 Phage lysis protein, holin; Region: Phage_holin; cl04675 288681010326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681010327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681010328 putative substrate translocation pore; other site 288681010329 Helix-turn-helix domains; Region: HTH; cl00088 288681010330 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 288681010331 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 288681010332 THF binding site; other site 288681010333 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 288681010334 substrate binding site [chemical binding]; other site 288681010335 THF binding site; other site 288681010336 zinc-binding site [ion binding]; other site 288681010337 Competence protein J (ComJ); Region: ComJ; pfam11033 288681010338 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 288681010339 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681010340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681010341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681010342 dimer interface [polypeptide binding]; other site 288681010343 phosphorylation site [posttranslational modification] 288681010344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681010345 ATP binding site [chemical binding]; other site 288681010346 Mg2+ binding site [ion binding]; other site 288681010347 G-X-G motif; other site 288681010348 aminotransferase A; Validated; Region: PRK07683 288681010349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681010350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010351 homodimer interface [polypeptide binding]; other site 288681010352 catalytic residue [active] 288681010353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681010354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681010355 DNA binding site [nucleotide binding] 288681010356 domain linker motif; other site 288681010357 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 288681010358 putative dimerization interface [polypeptide binding]; other site 288681010359 putative ligand binding site [chemical binding]; other site 288681010360 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 288681010361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681010362 dimer interface [polypeptide binding]; other site 288681010363 conserved gate region; other site 288681010364 putative PBP binding loops; other site 288681010365 ABC-ATPase subunit interface; other site 288681010366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681010367 dimer interface [polypeptide binding]; other site 288681010368 conserved gate region; other site 288681010369 putative PBP binding loops; other site 288681010370 ABC-ATPase subunit interface; other site 288681010371 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 288681010372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681010373 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 288681010374 homodimer interface [polypeptide binding]; other site 288681010375 maltodextrin glucosidase; Provisional; Region: PRK10785 288681010376 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 288681010377 active site 288681010378 homodimer interface [polypeptide binding]; other site 288681010379 catalytic site [active] 288681010380 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681010381 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681010382 Ca binding site [ion binding]; other site 288681010383 active site 288681010384 catalytic site [active] 288681010385 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681010386 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 288681010387 Walker A/P-loop; other site 288681010388 ATP binding site [chemical binding]; other site 288681010389 Q-loop/lid; other site 288681010390 ABC transporter signature motif; other site 288681010391 Walker B; other site 288681010392 D-loop; other site 288681010393 H-loop/switch region; other site 288681010394 TOBE domain; Region: TOBE_2; cl01440 288681010395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010396 NAD(P) binding site [chemical binding]; other site 288681010397 RDD family; Region: RDD; cl00746 288681010398 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 288681010399 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 288681010400 Predicted ATPase [General function prediction only]; Region: COG3910 288681010401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681010402 Walker A/P-loop; other site 288681010403 ATP binding site [chemical binding]; other site 288681010404 Q-loop/lid; other site 288681010405 ABC transporter signature motif; other site 288681010406 Walker B; other site 288681010407 D-loop; other site 288681010408 H-loop/switch region; other site 288681010409 putative acyltransferase; Provisional; Region: PRK05790 288681010410 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681010411 dimer interface [polypeptide binding]; other site 288681010412 active site 288681010413 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681010414 nudix motif; other site 288681010415 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 288681010416 hypothetical protein; Validated; Region: PRK07668 288681010417 hypothetical protein; Validated; Region: PRK07668 288681010418 hypothetical protein; Validated; Region: PRK07668 288681010419 Helix-turn-helix domains; Region: HTH; cl00088 288681010420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010421 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 288681010422 NAD(P) binding site [chemical binding]; other site 288681010423 active site 288681010424 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 288681010425 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 288681010426 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681010427 Predicted amidohydrolase [General function prediction only]; Region: COG0388 288681010428 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 288681010429 putative active site [active] 288681010430 catalytic triad [active] 288681010431 putative dimer interface [polypeptide binding]; other site 288681010432 transaminase; Reviewed; Region: PRK08068 288681010433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681010434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010435 homodimer interface [polypeptide binding]; other site 288681010436 catalytic residue [active] 288681010437 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 288681010438 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 288681010439 dimer interface [polypeptide binding]; other site 288681010440 active site 288681010441 catalytic residue [active] 288681010442 metal binding site [ion binding]; metal-binding site 288681010443 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681010444 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 288681010445 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 288681010446 intersubunit interface [polypeptide binding]; other site 288681010447 active site 288681010448 Zn2+ binding site [ion binding]; other site 288681010449 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 288681010450 Cupin domain; Region: Cupin_2; cl09118 288681010451 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 288681010452 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 288681010453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681010455 metal binding site [ion binding]; metal-binding site 288681010456 active site 288681010457 I-site; other site 288681010458 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681010459 dimer interface [polypeptide binding]; other site 288681010460 FMN binding site [chemical binding]; other site 288681010461 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 288681010462 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 288681010463 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 288681010464 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 288681010465 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 288681010466 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288681010467 dimerization domain swap beta strand [polypeptide binding]; other site 288681010468 regulatory protein interface [polypeptide binding]; other site 288681010469 active site 288681010470 regulatory phosphorylation site [posttranslational modification]; other site 288681010471 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681010472 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 288681010473 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681010474 active site turn [active] 288681010475 phosphorylation site [posttranslational modification] 288681010476 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 288681010477 HPr interaction site; other site 288681010478 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681010479 active site 288681010480 phosphorylation site [posttranslational modification] 288681010481 transcriptional antiterminator BglG; Provisional; Region: PRK09772 288681010482 CAT RNA binding domain; Region: CAT_RBD; cl03904 288681010483 PRD domain; Region: PRD; cl15445 288681010484 PRD domain; Region: PRD; cl15445 288681010485 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681010486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010487 active site 288681010488 motif I; other site 288681010489 motif II; other site 288681010490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010491 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681010492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681010493 DNA-binding site [nucleotide binding]; DNA binding site 288681010494 UTRA domain; Region: UTRA; cl01230 288681010495 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 288681010496 active site 288681010497 trimer interface [polypeptide binding]; other site 288681010498 allosteric site; other site 288681010499 active site lid [active] 288681010500 hexamer (dimer of trimers) interface [polypeptide binding]; other site 288681010501 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 288681010502 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 288681010503 active site 288681010504 dimer interface [polypeptide binding]; other site 288681010505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681010506 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 288681010507 ScpA/B protein; Region: ScpA_ScpB; cl00598 288681010508 Domain of unknown function (DUF309); Region: DUF309; cl00667 288681010509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681010510 Coenzyme A binding pocket [chemical binding]; other site 288681010511 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 288681010512 active site 288681010513 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 288681010514 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681010515 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681010516 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681010517 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 288681010518 SpoVA protein; Region: SpoVA; cl04298 288681010519 stage V sporulation protein AD; Validated; Region: PRK08304 288681010520 stage V sporulation protein AD; Provisional; Region: PRK12404 288681010521 SpoVA protein; Region: SpoVA; cl04298 288681010522 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 288681010523 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 288681010524 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 288681010525 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 288681010526 Na2 binding site [ion binding]; other site 288681010527 putative substrate binding site 1 [chemical binding]; other site 288681010528 Na binding site 1 [ion binding]; other site 288681010529 putative substrate binding site 2 [chemical binding]; other site 288681010530 sporulation sigma factor SigF; Validated; Region: PRK05572 288681010531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681010532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681010533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681010534 DNA binding residues [nucleotide binding] 288681010535 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 288681010536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681010537 ATP binding site [chemical binding]; other site 288681010538 Mg2+ binding site [ion binding]; other site 288681010539 G-X-G motif; other site 288681010540 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 288681010541 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681010542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681010543 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 288681010544 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681010545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681010546 DNA-binding site [nucleotide binding]; DNA binding site 288681010547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681010548 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681010549 Walker A/P-loop; other site 288681010550 ATP binding site [chemical binding]; other site 288681010551 Q-loop/lid; other site 288681010552 ABC transporter signature motif; other site 288681010553 Walker B; other site 288681010554 D-loop; other site 288681010555 H-loop/switch region; other site 288681010556 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681010557 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681010558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681010559 Helix-turn-helix domains; Region: HTH; cl00088 288681010560 Helix-turn-helix domains; Region: HTH; cl00088 288681010561 Protein of unknown function (DUF541); Region: SIMPL; cl01077 288681010562 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681010563 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 288681010564 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 288681010565 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 288681010566 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681010567 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681010568 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 288681010569 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288681010570 Sulfatase; Region: Sulfatase; cl10460 288681010571 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 288681010572 FixH; Region: FixH; cl01254 288681010573 FixH; Region: FixH; cl01254 288681010574 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 288681010575 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 288681010576 active site 288681010577 Int/Topo IB signature motif; other site 288681010578 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 288681010579 ferric uptake regulator; Provisional; Region: fur; PRK09462 288681010580 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681010581 metal binding site 2 [ion binding]; metal-binding site 288681010582 putative DNA binding helix; other site 288681010583 metal binding site 1 [ion binding]; metal-binding site 288681010584 dimer interface [polypeptide binding]; other site 288681010585 structural Zn2+ binding site [ion binding]; other site 288681010586 Integral membrane protein DUF95; Region: DUF95; cl00572 288681010587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681010588 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681010589 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 288681010590 dimer interface [polypeptide binding]; other site 288681010591 ADP-ribose binding site [chemical binding]; other site 288681010592 active site 288681010593 nudix motif; other site 288681010594 metal binding site [ion binding]; metal-binding site 288681010595 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 288681010596 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681010597 active site 288681010598 catalytic tetrad [active] 288681010599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681010600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681010601 active site 288681010602 catalytic tetrad [active] 288681010603 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681010604 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 288681010605 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681010606 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 288681010607 putative active site [active] 288681010608 putative metal binding site [ion binding]; other site 288681010609 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681010610 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 288681010611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681010612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681010613 Predicted permease [General function prediction only]; Region: COG2056 288681010614 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 288681010615 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 288681010616 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681010617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681010618 DNA binding site [nucleotide binding] 288681010619 domain linker motif; other site 288681010620 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 288681010621 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681010622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681010623 Coenzyme A binding pocket [chemical binding]; other site 288681010624 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681010625 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 288681010626 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 288681010627 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681010628 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681010629 catalytic motif [active] 288681010630 Zn binding site [ion binding]; other site 288681010631 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 288681010632 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 288681010633 Lumazine binding domain; Region: Lum_binding; pfam00677 288681010634 Lumazine binding domain; Region: Lum_binding; pfam00677 288681010635 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 288681010636 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 288681010637 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681010638 dimerization interface [polypeptide binding]; other site 288681010639 active site 288681010640 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 288681010641 homopentamer interface [polypeptide binding]; other site 288681010642 active site 288681010643 biotin synthase; Validated; Region: PRK06256 288681010644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681010645 FeS/SAM binding site; other site 288681010646 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 288681010647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681010648 S-adenosylmethionine binding site [chemical binding]; other site 288681010649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681010650 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 288681010651 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 288681010652 substrate-cofactor binding pocket; other site 288681010653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010654 catalytic residue [active] 288681010655 AAA domain; Region: AAA_26; pfam13500 288681010656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681010657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681010658 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 288681010659 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681010660 inhibitor-cofactor binding pocket; inhibition site 288681010661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010662 catalytic residue [active] 288681010663 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681010664 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 288681010665 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681010666 active site 288681010667 metal binding site [ion binding]; metal-binding site 288681010668 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681010669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288681010670 active site 288681010671 catalytic triad [active] 288681010672 oxyanion hole [active] 288681010673 Helix-turn-helix domains; Region: HTH; cl00088 288681010674 ornithine carbamoyltransferase; Provisional; Region: PRK00779 288681010675 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288681010676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010677 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 288681010678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681010679 inhibitor-cofactor binding pocket; inhibition site 288681010680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010681 catalytic residue [active] 288681010682 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 288681010683 nucleotide binding site [chemical binding]; other site 288681010684 N-acetyl-L-glutamate binding site [chemical binding]; other site 288681010685 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 288681010686 heterotetramer interface [polypeptide binding]; other site 288681010687 active site pocket [active] 288681010688 cleavage site 288681010689 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 288681010690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010691 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 288681010692 YqzH-like protein; Region: YqzH; pfam14164 288681010693 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 288681010694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010695 NAD(P) binding site [chemical binding]; other site 288681010696 active site 288681010697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681010698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010699 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 288681010700 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 288681010701 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 288681010702 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 288681010703 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 288681010704 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 288681010705 putative L-serine binding site [chemical binding]; other site 288681010706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681010707 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 288681010708 DNA polymerase IV; Validated; Region: PRK01810 288681010709 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 288681010710 active site 288681010711 DNA binding site [nucleotide binding] 288681010712 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 288681010713 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 288681010714 peptidase T-like protein; Region: PepT-like; TIGR01883 288681010715 metal binding site [ion binding]; metal-binding site 288681010716 putative dimer interface [polypeptide binding]; other site 288681010717 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681010718 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681010719 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 288681010720 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 288681010721 Predicted membrane protein [Function unknown]; Region: COG4129 288681010722 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 288681010723 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 288681010724 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681010725 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 288681010726 Walker A/P-loop; other site 288681010727 ATP binding site [chemical binding]; other site 288681010728 Q-loop/lid; other site 288681010729 ABC transporter signature motif; other site 288681010730 Walker B; other site 288681010731 D-loop; other site 288681010732 H-loop/switch region; other site 288681010733 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288681010734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681010735 dimer interface [polypeptide binding]; other site 288681010736 conserved gate region; other site 288681010737 putative PBP binding loops; other site 288681010738 ABC-ATPase subunit interface; other site 288681010739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681010740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681010741 substrate binding pocket [chemical binding]; other site 288681010742 membrane-bound complex binding site; other site 288681010743 hinge residues; other site 288681010744 Disulphide isomerase; Region: Disulph_isomer; cl05813 288681010745 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 288681010746 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681010747 nudix motif; other site 288681010748 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681010749 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681010750 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681010751 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681010752 E3 interaction surface; other site 288681010753 lipoyl attachment site [posttranslational modification]; other site 288681010754 e3 binding domain; Region: E3_binding; pfam02817 288681010755 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 288681010756 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681010757 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681010758 alpha subunit interface [polypeptide binding]; other site 288681010759 TPP binding site [chemical binding]; other site 288681010760 heterodimer interface [polypeptide binding]; other site 288681010761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681010762 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 288681010763 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288681010764 tetramer interface [polypeptide binding]; other site 288681010765 TPP-binding site [chemical binding]; other site 288681010766 heterodimer interface [polypeptide binding]; other site 288681010767 phosphorylation loop region [posttranslational modification] 288681010768 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 288681010769 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 288681010770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681010771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681010772 Acetokinase family; Region: Acetate_kinase; cl01029 288681010773 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 288681010774 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 288681010775 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 288681010776 NAD binding site [chemical binding]; other site 288681010777 Phe binding site; other site 288681010778 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 288681010779 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 288681010780 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681010781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681010782 putative active site [active] 288681010783 heme pocket [chemical binding]; other site 288681010784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681010785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681010786 Walker A motif; other site 288681010787 ATP binding site [chemical binding]; other site 288681010788 Walker B motif; other site 288681010789 arginine finger; other site 288681010790 Helix-turn-helix domains; Region: HTH; cl00088 288681010791 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 288681010792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681010793 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 288681010794 active site 288681010795 catalytic site [active] 288681010796 metal binding site [ion binding]; metal-binding site 288681010797 dimer interface [polypeptide binding]; other site 288681010798 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 288681010799 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681010800 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 288681010801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681010802 active site 288681010803 phosphorylation site [posttranslational modification] 288681010804 intermolecular recognition site; other site 288681010805 dimerization interface [polypeptide binding]; other site 288681010806 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 288681010807 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 288681010808 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288681010809 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 288681010810 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 288681010811 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 288681010812 Walker A/P-loop; other site 288681010813 ATP binding site [chemical binding]; other site 288681010814 Q-loop/lid; other site 288681010815 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 288681010816 ABC transporter signature motif; other site 288681010817 Walker B; other site 288681010818 D-loop; other site 288681010819 H-loop/switch region; other site 288681010820 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 288681010821 arginine repressor; Provisional; Region: PRK04280 288681010822 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 288681010823 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 288681010824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681010825 RNA binding surface [nucleotide binding]; other site 288681010826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681010827 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 288681010828 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 288681010829 TPP-binding site; other site 288681010830 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681010831 PYR/PP interface [polypeptide binding]; other site 288681010832 dimer interface [polypeptide binding]; other site 288681010833 TPP binding site [chemical binding]; other site 288681010834 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681010835 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288681010836 substrate binding pocket [chemical binding]; other site 288681010837 chain length determination region; other site 288681010838 substrate-Mg2+ binding site; other site 288681010839 catalytic residues [active] 288681010840 aspartate-rich region 1; other site 288681010841 active site lid residues [active] 288681010842 aspartate-rich region 2; other site 288681010843 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 288681010844 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 288681010845 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 288681010846 generic binding surface II; other site 288681010847 generic binding surface I; other site 288681010848 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 288681010849 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 288681010850 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 288681010851 homodimer interface [polypeptide binding]; other site 288681010852 NADP binding site [chemical binding]; other site 288681010853 substrate binding site [chemical binding]; other site 288681010854 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 288681010855 putative RNA binding site [nucleotide binding]; other site 288681010856 Asp23 family; Region: Asp23; cl00574 288681010857 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 288681010858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010859 ATP-grasp domain; Region: ATP-grasp_4; cl03087 288681010860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 288681010861 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 288681010862 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681010863 carboxyltransferase (CT) interaction site; other site 288681010864 biotinylation site [posttranslational modification]; other site 288681010865 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 288681010866 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 288681010867 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 288681010868 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 288681010869 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 288681010870 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 288681010871 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 288681010872 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 288681010873 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 288681010874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681010875 Walker A motif; other site 288681010876 ATP binding site [chemical binding]; other site 288681010877 Walker B motif; other site 288681010878 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 288681010879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681010880 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681010881 elongation factor P; Validated; Region: PRK00529 288681010882 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 288681010883 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 288681010884 RNA binding site [nucleotide binding]; other site 288681010885 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 288681010886 RNA binding site [nucleotide binding]; other site 288681010887 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681010888 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681010889 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681010890 active site 288681010891 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 288681010892 trimer interface [polypeptide binding]; other site 288681010893 active site 288681010894 dimer interface [polypeptide binding]; other site 288681010895 Conserved membrane protein YqhR; Region: YqhR; pfam11085 288681010896 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 288681010897 CCC1-related family of proteins; Region: CCC1_like; cl00278 288681010898 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 288681010899 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681010900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010901 motif II; other site 288681010902 manganese transport transcriptional regulator; Provisional; Region: PRK03902 288681010903 Helix-turn-helix domains; Region: HTH; cl00088 288681010904 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 288681010905 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 288681010906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681010907 FeS/SAM binding site; other site 288681010908 Helix-turn-helix domains; Region: HTH; cl00088 288681010909 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288681010910 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 288681010911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681010912 active site residue [active] 288681010913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681010914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681010915 DNA binding site [nucleotide binding] 288681010916 domain linker motif; other site 288681010917 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681010918 putative dimerization interface [polypeptide binding]; other site 288681010919 putative ligand binding site [chemical binding]; other site 288681010920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681010921 Helix-turn-helix domains; Region: HTH; cl00088 288681010922 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288681010923 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 288681010924 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 288681010925 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681010926 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681010927 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681010928 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681010929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681010930 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681010931 Walker A/P-loop; other site 288681010932 ATP binding site [chemical binding]; other site 288681010933 Q-loop/lid; other site 288681010934 ABC transporter signature motif; other site 288681010935 Walker B; other site 288681010936 D-loop; other site 288681010937 H-loop/switch region; other site 288681010938 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681010939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681010940 DNA-binding site [nucleotide binding]; DNA binding site 288681010941 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 288681010942 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 288681010943 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 288681010944 tetramer interface [polypeptide binding]; other site 288681010945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010946 catalytic residue [active] 288681010947 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 288681010948 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 288681010949 tetramer interface [polypeptide binding]; other site 288681010950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010951 catalytic residue [active] 288681010952 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 288681010953 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 288681010954 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 288681010955 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 288681010956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681010957 ATP binding site [chemical binding]; other site 288681010958 putative Mg++ binding site [ion binding]; other site 288681010959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681010960 nucleotide binding region [chemical binding]; other site 288681010961 ATP-binding site [chemical binding]; other site 288681010962 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 288681010963 YqzE-like protein; Region: YqzE; pfam14038 288681010964 shikimate kinase; Reviewed; Region: aroK; PRK00131 288681010965 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 288681010966 ADP binding site [chemical binding]; other site 288681010967 magnesium binding site [ion binding]; other site 288681010968 putative shikimate binding site; other site 288681010969 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 288681010970 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 288681010971 ComG operon protein 7; Region: ComGG; pfam14173 288681010972 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 288681010973 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 288681010974 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 288681010975 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 288681010976 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 288681010977 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 288681010978 Type II/IV secretion system protein; Region: T2SE; pfam00437 288681010979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681010980 Walker A motif; other site 288681010981 ATP binding site [chemical binding]; other site 288681010982 Walker B motif; other site 288681010983 Predicted transcriptional regulator [Transcription]; Region: COG2345 288681010984 Helix-turn-helix domains; Region: HTH; cl00088 288681010985 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 288681010986 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681010987 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681010988 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 288681010989 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 288681010990 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 288681010991 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 288681010992 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 288681010993 active site 288681010994 homodimer interface [polypeptide binding]; other site 288681010995 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 288681010996 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 288681010997 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 288681010998 substrate binding pocket [chemical binding]; other site 288681010999 dimer interface [polypeptide binding]; other site 288681011000 inhibitor binding site; inhibition site 288681011001 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 288681011002 B12 binding site [chemical binding]; other site 288681011003 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 288681011004 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 288681011005 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 288681011006 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 288681011007 FAD binding site [chemical binding]; other site 288681011008 cystathionine gamma-synthase; Reviewed; Region: PRK08247 288681011009 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011010 homodimer interface [polypeptide binding]; other site 288681011011 substrate-cofactor binding pocket; other site 288681011012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011013 catalytic residue [active] 288681011014 cystathionine beta-lyase; Provisional; Region: PRK08064 288681011015 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011016 homodimer interface [polypeptide binding]; other site 288681011017 substrate-cofactor binding pocket; other site 288681011018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011019 catalytic residue [active] 288681011020 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681011021 catalytic triad [active] 288681011022 conserved cis-peptide bond; other site 288681011023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011024 dimerization interface [polypeptide binding]; other site 288681011025 putative DNA binding site [nucleotide binding]; other site 288681011026 putative Zn2+ binding site [ion binding]; other site 288681011027 Uncharacterized conserved protein [Function unknown]; Region: COG1565 288681011028 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 288681011029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681011030 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 288681011031 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 288681011032 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 288681011033 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 288681011034 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 288681011035 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 288681011036 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 288681011037 active site 288681011038 Substrate binding site; other site 288681011039 Mg++ binding site; other site 288681011040 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 288681011041 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 288681011042 active site 288681011043 metal binding site [ion binding]; metal-binding site 288681011044 substrate binding site [chemical binding]; other site 288681011045 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 288681011046 PhoU domain; Region: PhoU; pfam01895 288681011047 PhoU domain; Region: PhoU; pfam01895 288681011048 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 288681011049 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 288681011050 Walker A/P-loop; other site 288681011051 ATP binding site [chemical binding]; other site 288681011052 Q-loop/lid; other site 288681011053 ABC transporter signature motif; other site 288681011054 Walker B; other site 288681011055 D-loop; other site 288681011056 H-loop/switch region; other site 288681011057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011058 dimer interface [polypeptide binding]; other site 288681011059 conserved gate region; other site 288681011060 putative PBP binding loops; other site 288681011061 ABC-ATPase subunit interface; other site 288681011062 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 288681011063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011064 dimer interface [polypeptide binding]; other site 288681011065 conserved gate region; other site 288681011066 putative PBP binding loops; other site 288681011067 ABC-ATPase subunit interface; other site 288681011068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681011069 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681011070 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681011071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681011072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681011073 putative substrate translocation pore; other site 288681011074 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681011075 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681011076 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681011077 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 288681011078 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 288681011079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288681011080 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288681011081 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681011082 metal binding site 2 [ion binding]; metal-binding site 288681011083 putative DNA binding helix; other site 288681011084 metal binding site 1 [ion binding]; metal-binding site 288681011085 dimer interface [polypeptide binding]; other site 288681011086 structural Zn2+ binding site [ion binding]; other site 288681011087 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681011088 ABC-ATPase subunit interface; other site 288681011089 dimer interface [polypeptide binding]; other site 288681011090 putative PBP binding regions; other site 288681011091 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288681011092 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 288681011093 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681011094 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681011095 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681011096 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681011097 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 288681011098 endonuclease IV; Provisional; Region: PRK01060 288681011099 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 288681011100 AP (apurinic/apyrimidinic) site pocket; other site 288681011101 DNA interaction; other site 288681011102 Metal-binding active site; metal-binding site 288681011103 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681011104 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681011105 ATP binding site [chemical binding]; other site 288681011106 Mg++ binding site [ion binding]; other site 288681011107 motif III; other site 288681011108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681011109 nucleotide binding region [chemical binding]; other site 288681011110 ATP-binding site [chemical binding]; other site 288681011111 YqfQ-like protein; Region: YqfQ; pfam14181 288681011112 LytB protein; Region: LYTB; cl00507 288681011113 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 288681011114 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 288681011115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 288681011116 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 288681011117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681011118 Cytochrome c; Region: Cytochrom_C; cl11414 288681011119 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 288681011120 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 288681011121 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 288681011122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681011123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681011124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681011125 DNA binding residues [nucleotide binding] 288681011126 DNA primase; Validated; Region: dnaG; PRK05667 288681011127 CHC2 zinc finger; Region: zf-CHC2; cl15369 288681011128 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 288681011129 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 288681011130 active site 288681011131 metal binding site [ion binding]; metal-binding site 288681011132 interdomain interaction site; other site 288681011133 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 288681011134 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 288681011135 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 288681011136 Helix-turn-helix domains; Region: HTH; cl00088 288681011137 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 288681011138 FOG: CBS domain [General function prediction only]; Region: COG0517 288681011139 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 288681011140 Recombination protein O N terminal; Region: RecO_N; cl15812 288681011141 Recombination protein O C terminal; Region: RecO_C; pfam02565 288681011142 GTPase Era; Reviewed; Region: era; PRK00089 288681011143 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 288681011144 G1 box; other site 288681011145 GTP/Mg2+ binding site [chemical binding]; other site 288681011146 Switch I region; other site 288681011147 G2 box; other site 288681011148 Switch II region; other site 288681011149 G3 box; other site 288681011150 G4 box; other site 288681011151 G5 box; other site 288681011152 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 288681011153 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681011154 active site 288681011155 catalytic motif [active] 288681011156 Zn binding site [ion binding]; other site 288681011157 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 288681011158 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 288681011159 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 288681011160 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 288681011161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681011162 Zn2+ binding site [ion binding]; other site 288681011163 Mg2+ binding site [ion binding]; other site 288681011164 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 288681011165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681011166 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 288681011167 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 288681011168 YabP family; Region: YabP; cl06766 288681011169 GatB domain; Region: GatB_Yqey; cl11497 288681011170 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 288681011171 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 288681011172 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 288681011173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011174 FeS/SAM binding site; other site 288681011175 TRAM domain; Region: TRAM; cl01282 288681011176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 288681011177 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 288681011178 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 288681011179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011180 S-adenosylmethionine binding site [chemical binding]; other site 288681011181 chaperone protein DnaJ; Provisional; Region: PRK14280 288681011182 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 288681011183 HSP70 interaction site [polypeptide binding]; other site 288681011184 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 288681011185 substrate binding site [polypeptide binding]; other site 288681011186 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 288681011187 Zn binding sites [ion binding]; other site 288681011188 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 288681011189 dimer interface [polypeptide binding]; other site 288681011190 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 288681011191 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 288681011192 dimer interface [polypeptide binding]; other site 288681011193 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 288681011194 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 288681011195 Helix-turn-helix domains; Region: HTH; cl00088 288681011196 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 288681011197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011198 FeS/SAM binding site; other site 288681011199 HemN C-terminal domain; Region: HemN_C; pfam06969 288681011200 Helix-turn-helix domains; Region: HTH; cl00088 288681011201 GTP-binding protein LepA; Provisional; Region: PRK05433 288681011202 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 288681011203 G1 box; other site 288681011204 putative GEF interaction site [polypeptide binding]; other site 288681011205 GTP/Mg2+ binding site [chemical binding]; other site 288681011206 Switch I region; other site 288681011207 G2 box; other site 288681011208 G3 box; other site 288681011209 Switch II region; other site 288681011210 G4 box; other site 288681011211 G5 box; other site 288681011212 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 288681011213 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 288681011214 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 288681011215 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 288681011216 Germination protease; Region: Peptidase_A25; cl04057 288681011217 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 288681011218 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 288681011219 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 288681011220 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 288681011221 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 288681011222 Competence protein; Region: Competence; cl00471 288681011223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681011224 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 288681011225 catalytic motif [active] 288681011226 Zn binding site [ion binding]; other site 288681011227 SLBB domain; Region: SLBB; pfam10531 288681011228 comEA protein; Region: comE; TIGR01259 288681011229 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 288681011230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681011231 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 288681011232 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 288681011233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011234 S-adenosylmethionine binding site [chemical binding]; other site 288681011235 Oligomerisation domain; Region: Oligomerisation; cl00519 288681011236 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 288681011237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681011238 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 288681011239 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 288681011240 active site 288681011241 (T/H)XGH motif; other site 288681011242 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 288681011243 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 288681011244 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 288681011245 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288681011246 shikimate binding site; other site 288681011247 NAD(P) binding site [chemical binding]; other site 288681011248 GTPase YqeH; Provisional; Region: PRK13796 288681011249 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 288681011250 GTP/Mg2+ binding site [chemical binding]; other site 288681011251 G4 box; other site 288681011252 G5 box; other site 288681011253 G1 box; other site 288681011254 Switch I region; other site 288681011255 G2 box; other site 288681011256 G3 box; other site 288681011257 Switch II region; other site 288681011258 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 288681011259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681011260 active site 288681011261 motif I; other site 288681011262 motif II; other site 288681011263 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 288681011264 sporulation sigma factor SigK; Reviewed; Region: PRK05803 288681011265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681011266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681011267 DNA binding residues [nucleotide binding] 288681011268 Integrase core domain; Region: rve; cl01316 288681011269 Integrase core domain; Region: rve_3; cl15866 288681011270 HTH-like domain; Region: HTH_21; pfam13276 288681011271 Helix-turn-helix domains; Region: HTH; cl00088 288681011272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681011273 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681011274 dimer interface [polypeptide binding]; other site 288681011275 FMN binding site [chemical binding]; other site 288681011276 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681011277 synthetase active site [active] 288681011278 NTP binding site [chemical binding]; other site 288681011279 metal binding site [ion binding]; metal-binding site 288681011280 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 288681011281 dimer interface [polypeptide binding]; other site 288681011282 Alkaline phosphatase homologues; Region: alkPPc; smart00098 288681011283 active site 288681011284 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681011285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011286 Coenzyme A binding pocket [chemical binding]; other site 288681011287 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681011288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681011289 CHAT domain; Region: CHAT; pfam12770 288681011290 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 288681011291 catalytic core [active] 288681011292 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 288681011293 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681011294 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681011295 putative active site [active] 288681011296 catalytic triad [active] 288681011297 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 288681011298 putative integrin binding motif; other site 288681011299 PA/protease domain interface [polypeptide binding]; other site 288681011300 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681011301 FlgD Ig-like domain; Region: FlgD_ig; cl15790 288681011302 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 288681011303 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 288681011304 cofactor binding site; other site 288681011305 metal binding site [ion binding]; metal-binding site 288681011306 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 288681011307 aromatic arch; other site 288681011308 DCoH dimer interaction site [polypeptide binding]; other site 288681011309 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 288681011310 DCoH tetramer interaction site [polypeptide binding]; other site 288681011311 substrate binding site [chemical binding]; other site 288681011312 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681011313 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 288681011314 putative metal binding site [ion binding]; other site 288681011315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681011316 active site 288681011317 metal binding site [ion binding]; metal-binding site 288681011318 DoxX; Region: DoxX; cl00976 288681011319 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681011320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681011321 non-specific DNA binding site [nucleotide binding]; other site 288681011322 salt bridge; other site 288681011323 sequence-specific DNA binding site [nucleotide binding]; other site 288681011324 Cupin domain; Region: Cupin_2; cl09118 288681011325 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288681011326 active site 2 [active] 288681011327 active site 1 [active] 288681011328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011329 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681011330 Coenzyme A binding pocket [chemical binding]; other site 288681011331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681011332 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681011333 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 288681011334 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681011335 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681011336 Walker A/P-loop; other site 288681011337 ATP binding site [chemical binding]; other site 288681011338 Q-loop/lid; other site 288681011339 ABC transporter signature motif; other site 288681011340 Walker B; other site 288681011341 D-loop; other site 288681011342 H-loop/switch region; other site 288681011343 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681011344 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681011345 ABC-ATPase subunit interface; other site 288681011346 dimer interface [polypeptide binding]; other site 288681011347 putative PBP binding regions; other site 288681011348 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 288681011349 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681011350 intersubunit interface [polypeptide binding]; other site 288681011351 YrhC-like protein; Region: YrhC; pfam14143 288681011352 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 288681011353 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 288681011354 putative catalytic cysteine [active] 288681011355 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 288681011356 putative active site [active] 288681011357 metal binding site [ion binding]; metal-binding site 288681011358 cystathionine beta-lyase; Provisional; Region: PRK07671 288681011359 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011360 homodimer interface [polypeptide binding]; other site 288681011361 substrate-cofactor binding pocket; other site 288681011362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011363 catalytic residue [active] 288681011364 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288681011365 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681011366 dimer interface [polypeptide binding]; other site 288681011367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011368 catalytic residue [active] 288681011369 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 288681011370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011371 S-adenosylmethionine binding site [chemical binding]; other site 288681011372 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 288681011373 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 288681011374 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681011375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681011376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681011377 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 288681011378 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 288681011379 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 288681011380 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 288681011381 ATP-binding site [chemical binding]; other site 288681011382 Sugar specificity; other site 288681011383 Pyrimidine base specificity; other site 288681011384 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 288681011385 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 288681011386 Peptidase family U32; Region: Peptidase_U32; cl03113 288681011387 Protein of unknown function (DUF556); Region: DUF556; cl00822 288681011388 Peptidase family U32; Region: Peptidase_U32; cl03113 288681011389 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288681011390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011391 S-adenosylmethionine binding site [chemical binding]; other site 288681011392 YceG-like family; Region: YceG; pfam02618 288681011393 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 288681011394 dimerization interface [polypeptide binding]; other site 288681011395 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 288681011396 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 288681011397 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 288681011398 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 288681011399 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 288681011400 motif 1; other site 288681011401 active site 288681011402 motif 2; other site 288681011403 motif 3; other site 288681011404 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 288681011405 DHHA1 domain; Region: DHHA1; pfam02272 288681011406 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681011407 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 288681011408 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 288681011409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681011410 Family description; Region: UvrD_C_2; cl15862 288681011411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681011412 binding surface 288681011413 TPR motif; other site 288681011414 TPR repeat; Region: TPR_11; pfam13414 288681011415 TPR repeat; Region: TPR_11; pfam13414 288681011416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681011417 binding surface 288681011418 TPR motif; other site 288681011419 TPR repeat; Region: TPR_11; pfam13414 288681011420 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 288681011421 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 288681011422 Ligand Binding Site [chemical binding]; other site 288681011423 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681011424 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 288681011425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681011426 catalytic residue [active] 288681011427 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681011428 Helix-turn-helix domains; Region: HTH; cl00088 288681011429 recombination factor protein RarA; Reviewed; Region: PRK13342 288681011430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011431 Walker A motif; other site 288681011432 ATP binding site [chemical binding]; other site 288681011433 Walker B motif; other site 288681011434 arginine finger; other site 288681011435 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 288681011436 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 288681011437 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681011438 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 288681011439 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 288681011440 putative ATP binding site [chemical binding]; other site 288681011441 putative substrate interface [chemical binding]; other site 288681011442 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 288681011443 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 288681011444 dimer interface [polypeptide binding]; other site 288681011445 anticodon binding site; other site 288681011446 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 288681011447 homodimer interface [polypeptide binding]; other site 288681011448 motif 1; other site 288681011449 active site 288681011450 motif 2; other site 288681011451 GAD domain; Region: GAD; pfam02938 288681011452 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 288681011453 motif 3; other site 288681011454 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 288681011455 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 288681011456 dimer interface [polypeptide binding]; other site 288681011457 motif 1; other site 288681011458 active site 288681011459 motif 2; other site 288681011460 motif 3; other site 288681011461 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 288681011462 anticodon binding site; other site 288681011463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681011464 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681011465 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 288681011466 putative active site [active] 288681011467 dimerization interface [polypeptide binding]; other site 288681011468 putative tRNAtyr binding site [nucleotide binding]; other site 288681011469 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 288681011470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681011471 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681011472 synthetase active site [active] 288681011473 NTP binding site [chemical binding]; other site 288681011474 metal binding site [ion binding]; metal-binding site 288681011475 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 288681011476 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 288681011477 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681011478 active site 288681011479 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 288681011480 DHH family; Region: DHH; pfam01368 288681011481 DHHA1 domain; Region: DHHA1; pfam02272 288681011482 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 288681011483 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 288681011484 Cation efflux family; Region: Cation_efflux; cl00316 288681011485 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 288681011486 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 288681011487 Protein export membrane protein; Region: SecD_SecF; cl14618 288681011488 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 288681011489 Protein export membrane protein; Region: SecD_SecF; cl14618 288681011490 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 288681011491 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681011492 MatE; Region: MatE; cl10513 288681011493 MatE; Region: MatE; cl10513 288681011494 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681011495 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 288681011496 Preprotein translocase subunit; Region: YajC; cl00806 288681011497 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 288681011498 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 288681011499 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 288681011500 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 288681011501 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 288681011502 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 288681011503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011504 Walker A motif; other site 288681011505 ATP binding site [chemical binding]; other site 288681011506 Walker B motif; other site 288681011507 arginine finger; other site 288681011508 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 288681011509 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 288681011510 RuvA N terminal domain; Region: RuvA_N; pfam01330 288681011511 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 288681011512 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681011513 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681011514 putative ligand binding residues [chemical binding]; other site 288681011515 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 288681011516 BofC C-terminal domain; Region: BofC_C; pfam08955 288681011517 EamA-like transporter family; Region: EamA; cl01037 288681011518 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681011519 EamA-like transporter family; Region: EamA; cl01037 288681011520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011521 dimerization interface [polypeptide binding]; other site 288681011522 putative DNA binding site [nucleotide binding]; other site 288681011523 putative Zn2+ binding site [ion binding]; other site 288681011524 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681011525 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681011526 translation initiation factor IF-2; Validated; Region: infB; PRK05306 288681011527 Quinolinate synthetase A protein; Region: NadA; cl00420 288681011528 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 288681011529 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 288681011530 dimerization interface [polypeptide binding]; other site 288681011531 active site 288681011532 L-aspartate oxidase; Provisional; Region: PRK08071 288681011533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681011534 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288681011535 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681011536 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 288681011537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681011538 catalytic residue [active] 288681011539 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 288681011540 Helix-turn-helix domains; Region: HTH; cl00088 288681011541 3H domain; Region: 3H; pfam02829 288681011542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 288681011543 MOSC domain; Region: MOSC; pfam03473 288681011544 3-alpha domain; Region: 3-alpha; pfam03475 288681011545 prephenate dehydratase; Provisional; Region: PRK11898 288681011546 Prephenate dehydratase; Region: PDT; pfam00800 288681011547 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 288681011548 putative L-Phe binding site [chemical binding]; other site 288681011549 FtsX-like permease family; Region: FtsX; cl15850 288681011550 FtsX-like permease family; Region: FtsX; cl15850 288681011551 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681011552 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681011553 Walker A/P-loop; other site 288681011554 ATP binding site [chemical binding]; other site 288681011555 Q-loop/lid; other site 288681011556 ABC transporter signature motif; other site 288681011557 Walker B; other site 288681011558 D-loop; other site 288681011559 H-loop/switch region; other site 288681011560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 288681011561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681011562 ATP binding site [chemical binding]; other site 288681011563 Mg2+ binding site [ion binding]; other site 288681011564 G-X-G motif; other site 288681011565 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681011566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681011567 active site 288681011568 phosphorylation site [posttranslational modification] 288681011569 intermolecular recognition site; other site 288681011570 dimerization interface [polypeptide binding]; other site 288681011571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681011572 DNA binding site [nucleotide binding] 288681011573 GTPase CgtA; Reviewed; Region: obgE; PRK12297 288681011574 GTP1/OBG; Region: GTP1_OBG; pfam01018 288681011575 Obg GTPase; Region: Obg; cd01898 288681011576 G1 box; other site 288681011577 GTP/Mg2+ binding site [chemical binding]; other site 288681011578 Switch I region; other site 288681011579 G2 box; other site 288681011580 G3 box; other site 288681011581 Switch II region; other site 288681011582 G4 box; other site 288681011583 G5 box; other site 288681011584 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 288681011585 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 288681011586 Protein of unknown function (DUF464); Region: DUF464; cl01080 288681011587 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 288681011588 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 288681011589 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 288681011590 homodimer interface [polypeptide binding]; other site 288681011591 oligonucleotide binding site [chemical binding]; other site 288681011592 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 288681011593 active site 288681011594 putative substrate binding region [chemical binding]; other site 288681011595 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681011596 septum site-determining protein MinD; Region: minD_bact; TIGR01968 288681011597 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 288681011598 Switch I; other site 288681011599 Switch II; other site 288681011600 septum formation inhibitor; Reviewed; Region: minC; PRK00513 288681011601 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 288681011602 rod shape-determining protein MreD; Region: MreD; cl01087 288681011603 rod shape-determining protein MreC; Provisional; Region: PRK13922 288681011604 rod shape-determining protein MreC; Region: MreC; pfam04085 288681011605 rod shape-determining protein MreB; Provisional; Region: PRK13927 288681011606 Cell division protein FtsA; Region: FtsA; cl11496 288681011607 hypothetical protein; Reviewed; Region: PRK00024 288681011608 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 288681011609 MPN+ (JAMM) motif; other site 288681011610 Zinc-binding site [ion binding]; other site 288681011611 Maf-like protein; Region: Maf; pfam02545 288681011612 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 288681011613 active site 288681011614 dimer interface [polypeptide binding]; other site 288681011615 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 288681011616 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681011617 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681011618 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 288681011619 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288681011620 active site 288681011621 HIGH motif; other site 288681011622 nucleotide binding site [chemical binding]; other site 288681011623 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288681011624 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 288681011625 active site 288681011626 KMSKS motif; other site 288681011627 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 288681011628 tRNA binding surface [nucleotide binding]; other site 288681011629 anticodon binding site; other site 288681011630 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 288681011631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681011632 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 288681011633 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681011634 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 288681011635 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681011636 inhibitor-cofactor binding pocket; inhibition site 288681011637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011638 catalytic residue [active] 288681011639 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 288681011640 dimer interface [polypeptide binding]; other site 288681011641 active site 288681011642 Schiff base residues; other site 288681011643 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 288681011644 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 288681011645 active site 288681011646 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 288681011647 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 288681011648 domain interfaces; other site 288681011649 active site 288681011650 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681011651 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 288681011652 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 288681011653 tRNA; other site 288681011654 putative tRNA binding site [nucleotide binding]; other site 288681011655 putative NADP binding site [chemical binding]; other site 288681011656 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 288681011657 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681011658 Helix-turn-helix domains; Region: HTH; cl00088 288681011659 OsmC-like protein; Region: OsmC; cl00767 288681011660 Predicted GTPase [General function prediction only]; Region: COG0218 288681011661 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 288681011662 G1 box; other site 288681011663 GTP/Mg2+ binding site [chemical binding]; other site 288681011664 Switch I region; other site 288681011665 G2 box; other site 288681011666 G3 box; other site 288681011667 Switch II region; other site 288681011668 G4 box; other site 288681011669 G5 box; other site 288681011670 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 288681011671 Found in ATP-dependent protease La (LON); Region: LON; smart00464 288681011672 Found in ATP-dependent protease La (LON); Region: LON; smart00464 288681011673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011674 Walker A motif; other site 288681011675 ATP binding site [chemical binding]; other site 288681011676 Walker B motif; other site 288681011677 arginine finger; other site 288681011678 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 288681011679 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 288681011680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011681 Walker A motif; other site 288681011682 ATP binding site [chemical binding]; other site 288681011683 Walker B motif; other site 288681011684 arginine finger; other site 288681011685 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 288681011686 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 288681011687 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 288681011688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011689 Walker A motif; other site 288681011690 ATP binding site [chemical binding]; other site 288681011691 Walker B motif; other site 288681011692 arginine finger; other site 288681011693 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 288681011694 trigger factor; Provisional; Region: tig; PRK01490 288681011695 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 288681011696 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 288681011697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681011698 binding surface 288681011699 TPR motif; other site 288681011700 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 288681011701 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 288681011702 HNH endonuclease; Region: HNH_3; pfam13392 288681011703 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681011704 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681011705 catalytic residues [active] 288681011706 catalytic nucleophile [active] 288681011707 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681011708 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681011709 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681011710 Synaptic Site I dimer interface [polypeptide binding]; other site 288681011711 DNA binding site [nucleotide binding] 288681011712 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681011713 DNA-binding interface [nucleotide binding]; DNA binding site 288681011714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011715 putative DNA binding site [nucleotide binding]; other site 288681011716 putative Zn2+ binding site [ion binding]; other site 288681011717 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 288681011718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681011719 active site 288681011720 DNA binding site [nucleotide binding] 288681011721 Int/Topo IB signature motif; other site 288681011722 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 288681011723 active site 288681011724 metal binding site [ion binding]; metal-binding site 288681011725 homotetramer interface [polypeptide binding]; other site 288681011726 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 288681011727 active site 288681011728 dimerization interface [polypeptide binding]; other site 288681011729 ribonuclease PH; Reviewed; Region: rph; PRK00173 288681011730 Ribonuclease PH; Region: RNase_PH_bact; cd11362 288681011731 hexamer interface [polypeptide binding]; other site 288681011732 active site 288681011733 Sporulation and spore germination; Region: Germane; cl11253 288681011734 Spore germination protein [General function prediction only]; Region: COG5401 288681011735 Sporulation and spore germination; Region: Germane; cl11253 288681011736 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288681011737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681011738 DNA binding residues [nucleotide binding] 288681011739 dimerization interface [polypeptide binding]; other site 288681011740 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681011741 EamA-like transporter family; Region: EamA; cl01037 288681011742 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681011743 EamA-like transporter family; Region: EamA; cl01037 288681011744 putative deaminase; Validated; Region: PRK06846 288681011745 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 288681011746 active site 288681011747 putative deaminase; Validated; Region: PRK06846 288681011748 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 288681011749 active site 288681011750 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 288681011751 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288681011752 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681011753 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 288681011754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011755 dimer interface [polypeptide binding]; other site 288681011756 conserved gate region; other site 288681011757 ABC-ATPase subunit interface; other site 288681011758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681011759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011760 dimer interface [polypeptide binding]; other site 288681011761 conserved gate region; other site 288681011762 putative PBP binding loops; other site 288681011763 ABC-ATPase subunit interface; other site 288681011764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681011765 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681011766 Walker A/P-loop; other site 288681011767 ATP binding site [chemical binding]; other site 288681011768 Q-loop/lid; other site 288681011769 ABC transporter signature motif; other site 288681011770 Walker B; other site 288681011771 D-loop; other site 288681011772 H-loop/switch region; other site 288681011773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681011774 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 288681011775 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 288681011776 Walker A/P-loop; other site 288681011777 ATP binding site [chemical binding]; other site 288681011778 Q-loop/lid; other site 288681011779 ABC transporter signature motif; other site 288681011780 Walker B; other site 288681011781 D-loop; other site 288681011782 H-loop/switch region; other site 288681011783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681011784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 288681011785 Histidine kinase; Region: His_kinase; pfam06580 288681011786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 288681011787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681011788 active site 288681011789 phosphorylation site [posttranslational modification] 288681011790 intermolecular recognition site; other site 288681011791 dimerization interface [polypeptide binding]; other site 288681011792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681011793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681011794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681011795 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288681011796 PspC domain; Region: PspC; cl00864 288681011797 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681011798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681011799 non-specific DNA binding site [nucleotide binding]; other site 288681011800 salt bridge; other site 288681011801 sequence-specific DNA binding site [nucleotide binding]; other site 288681011802 Cupin domain; Region: Cupin_2; cl09118 288681011803 EamA-like transporter family; Region: EamA; cl01037 288681011804 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 288681011805 amphipathic channel; other site 288681011806 Asn-Pro-Ala signature motifs; other site 288681011807 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681011808 Helix-turn-helix domains; Region: HTH; cl00088 288681011809 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 288681011810 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 288681011811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681011812 Walker A/P-loop; other site 288681011813 ATP binding site [chemical binding]; other site 288681011814 Q-loop/lid; other site 288681011815 ABC transporter signature motif; other site 288681011816 Walker B; other site 288681011817 D-loop; other site 288681011818 H-loop/switch region; other site 288681011819 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 288681011820 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 288681011821 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 288681011822 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 288681011823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 288681011824 ligand binding site [chemical binding]; other site 288681011825 flagellar motor protein MotA; Validated; Region: PRK08124 288681011826 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 288681011827 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 288681011828 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681011829 active site 288681011830 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 288681011831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 288681011832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681011833 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 288681011834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681011835 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288681011836 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 288681011837 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 288681011838 putative Iron-sulfur protein interface [polypeptide binding]; other site 288681011839 proximal heme binding site [chemical binding]; other site 288681011840 distal heme binding site [chemical binding]; other site 288681011841 putative dimer interface [polypeptide binding]; other site 288681011842 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 288681011843 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 288681011844 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681011845 GIY-YIG motif/motif A; other site 288681011846 active site 288681011847 catalytic site [active] 288681011848 putative DNA binding site [nucleotide binding]; other site 288681011849 metal binding site [ion binding]; metal-binding site 288681011850 UvrB/uvrC motif; Region: UVR; pfam02151 288681011851 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 288681011852 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681011853 catalytic residues [active] 288681011854 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 288681011855 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 288681011856 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 288681011857 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 288681011858 Ligand binding site [chemical binding]; other site 288681011859 Electron transfer flavoprotein domain; Region: ETF; pfam01012 288681011860 enoyl-CoA hydratase; Provisional; Region: PRK07658 288681011861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681011862 substrate binding site [chemical binding]; other site 288681011863 oxyanion hole (OAH) forming residues; other site 288681011864 trimer interface [polypeptide binding]; other site 288681011865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 288681011866 Helix-turn-helix domains; Region: HTH; cl00088 288681011867 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 288681011868 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 288681011869 AMP-binding enzyme; Region: AMP-binding; cl15778 288681011870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681011871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288681011872 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 288681011873 DinB superfamily; Region: DinB_2; pfam12867 288681011874 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681011875 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681011876 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681011877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681011878 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681011879 Walker A/P-loop; other site 288681011880 ATP binding site [chemical binding]; other site 288681011881 Q-loop/lid; other site 288681011882 ABC transporter signature motif; other site 288681011883 Walker B; other site 288681011884 D-loop; other site 288681011885 H-loop/switch region; other site 288681011886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681011887 dimer interface [polypeptide binding]; other site 288681011888 phosphorylation site [posttranslational modification] 288681011889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681011890 ATP binding site [chemical binding]; other site 288681011891 Mg2+ binding site [ion binding]; other site 288681011892 G-X-G motif; other site 288681011893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681011894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681011895 active site 288681011896 phosphorylation site [posttranslational modification] 288681011897 intermolecular recognition site; other site 288681011898 dimerization interface [polypeptide binding]; other site 288681011899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681011900 DNA binding site [nucleotide binding] 288681011901 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 288681011902 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 288681011903 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 288681011904 putative RNA binding site [nucleotide binding]; other site 288681011905 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 288681011906 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681011907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681011908 Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; Region: COG5077 288681011909 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681011910 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 288681011911 active site 288681011912 catalytic site [active] 288681011913 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681011914 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681011915 Walker A/P-loop; other site 288681011916 ATP binding site [chemical binding]; other site 288681011917 Q-loop/lid; other site 288681011918 ABC transporter signature motif; other site 288681011919 Walker B; other site 288681011920 D-loop; other site 288681011921 H-loop/switch region; other site 288681011922 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681011923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681011924 ABC-ATPase subunit interface; other site 288681011925 dimer interface [polypeptide binding]; other site 288681011926 putative PBP binding regions; other site 288681011927 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 288681011928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681011929 intersubunit interface [polypeptide binding]; other site 288681011930 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011931 heme-binding site [chemical binding]; other site 288681011932 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011933 heme-binding site [chemical binding]; other site 288681011934 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011935 heme-binding site [chemical binding]; other site 288681011936 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011937 heme-binding site [chemical binding]; other site 288681011938 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011939 heme-binding site [chemical binding]; other site 288681011940 heme uptake protein IsdC; Region: IsdC; TIGR03656 288681011941 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681011942 heme-binding site [chemical binding]; other site 288681011943 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 288681011944 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681011945 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681011946 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681011947 RNA binding surface [nucleotide binding]; other site 288681011948 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 288681011949 probable active site [active] 288681011950 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 288681011951 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 288681011952 Walker A/P-loop; other site 288681011953 ATP binding site [chemical binding]; other site 288681011954 Q-loop/lid; other site 288681011955 ABC transporter signature motif; other site 288681011956 Walker B; other site 288681011957 D-loop; other site 288681011958 H-loop/switch region; other site 288681011959 Smr domain; Region: Smr; cl02619 288681011960 hypothetical protein; Provisional; Region: PRK08609 288681011961 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 288681011962 active site 288681011963 primer binding site [nucleotide binding]; other site 288681011964 NTP binding site [chemical binding]; other site 288681011965 metal binding triad [ion binding]; metal-binding site 288681011966 LETM1-like protein; Region: LETM1; pfam07766 288681011967 Colicin V production protein; Region: Colicin_V; cl00567 288681011968 Cell division protein ZapA; Region: ZapA; cl01146 288681011969 ribonuclease HIII; Provisional; Region: PRK00996 288681011970 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 288681011971 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 288681011972 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681011973 active site 288681011974 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 288681011975 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 288681011976 putative dimer interface [polypeptide binding]; other site 288681011977 putative anticodon binding site; other site 288681011978 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 288681011979 homodimer interface [polypeptide binding]; other site 288681011980 motif 1; other site 288681011981 motif 2; other site 288681011982 active site 288681011983 motif 3; other site 288681011984 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 288681011985 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 288681011986 putative tRNA-binding site [nucleotide binding]; other site 288681011987 B3/4 domain; Region: B3_4; cl11458 288681011988 tRNA synthetase B5 domain; Region: B5; cl08394 288681011989 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 288681011990 dimer interface [polypeptide binding]; other site 288681011991 motif 1; other site 288681011992 motif 3; other site 288681011993 motif 2; other site 288681011994 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 288681011995 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 288681011996 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 288681011997 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 288681011998 dimer interface [polypeptide binding]; other site 288681011999 motif 1; other site 288681012000 active site 288681012001 motif 2; other site 288681012002 motif 3; other site 288681012003 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 288681012004 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 288681012005 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 288681012006 Small, acid-soluble spore protein I; Region: SSPI; cl07940 288681012007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681012008 CAAX protease self-immunity; Region: Abi; cl00558 288681012009 CAAX protease self-immunity; Region: Abi; cl00558 288681012010 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681012011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012012 putative substrate translocation pore; other site 288681012013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012014 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 288681012015 Helix-turn-helix domains; Region: HTH; cl00088 288681012016 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681012017 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681012018 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 288681012019 oligomer interface [polypeptide binding]; other site 288681012020 active site 288681012021 metal binding site [ion binding]; metal-binding site 288681012022 dUTPase; Region: dUTPase_2; pfam08761 288681012023 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681012024 active site 288681012025 homodimer interface [polypeptide binding]; other site 288681012026 metal binding site [ion binding]; metal-binding site 288681012027 ribosomal protein L20; Region: rpl20; CHL00068 288681012028 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 288681012029 23S rRNA binding site [nucleotide binding]; other site 288681012030 L21 binding site [polypeptide binding]; other site 288681012031 L13 binding site [polypeptide binding]; other site 288681012032 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 288681012033 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 288681012034 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 288681012035 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 288681012036 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 288681012037 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 288681012038 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 288681012039 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288681012040 active site 288681012041 dimer interface [polypeptide binding]; other site 288681012042 motif 1; other site 288681012043 motif 2; other site 288681012044 motif 3; other site 288681012045 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 288681012046 anticodon binding site; other site 288681012047 YtxC-like family; Region: YtxC; cl08500 288681012048 primosomal protein DnaI; Reviewed; Region: PRK08939 288681012049 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 288681012050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012051 Walker A motif; other site 288681012052 ATP binding site [chemical binding]; other site 288681012053 Walker B motif; other site 288681012054 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 288681012055 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 288681012056 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 288681012057 ATP cone domain; Region: ATP-cone; pfam03477 288681012058 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 288681012059 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 288681012060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012061 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 288681012062 dephospho-CoA kinase; Region: TIGR00152 288681012063 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 288681012064 CoA-binding site [chemical binding]; other site 288681012065 ATP-binding [chemical binding]; other site 288681012066 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 288681012067 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 288681012068 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 288681012069 DNA binding site [nucleotide binding] 288681012070 catalytic residue [active] 288681012071 H2TH interface [polypeptide binding]; other site 288681012072 putative catalytic residues [active] 288681012073 turnover-facilitating residue; other site 288681012074 intercalation triad [nucleotide binding]; other site 288681012075 8OG recognition residue [nucleotide binding]; other site 288681012076 putative reading head residues; other site 288681012077 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288681012078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288681012079 DNA polymerase I; Provisional; Region: PRK05755 288681012080 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 288681012081 active site 288681012082 metal binding site 1 [ion binding]; metal-binding site 288681012083 putative 5' ssDNA interaction site; other site 288681012084 metal binding site 3; metal-binding site 288681012085 metal binding site 2 [ion binding]; metal-binding site 288681012086 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 288681012087 putative DNA binding site [nucleotide binding]; other site 288681012088 putative metal binding site [ion binding]; other site 288681012089 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 288681012090 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 288681012091 active site 288681012092 DNA binding site [nucleotide binding] 288681012093 catalytic site [active] 288681012094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681012095 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 288681012096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681012097 putative active site [active] 288681012098 heme pocket [chemical binding]; other site 288681012099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012100 dimer interface [polypeptide binding]; other site 288681012101 phosphorylation site [posttranslational modification] 288681012102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012103 ATP binding site [chemical binding]; other site 288681012104 Mg2+ binding site [ion binding]; other site 288681012105 G-X-G motif; other site 288681012106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012108 active site 288681012109 phosphorylation site [posttranslational modification] 288681012110 intermolecular recognition site; other site 288681012111 dimerization interface [polypeptide binding]; other site 288681012112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012113 DNA binding site [nucleotide binding] 288681012114 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 288681012115 dimer interaction site [polypeptide binding]; other site 288681012116 substrate-binding tunnel; other site 288681012117 active site 288681012118 catalytic site [active] 288681012119 substrate binding site [chemical binding]; other site 288681012120 malate dehydrogenase; Reviewed; Region: PRK06223 288681012121 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 288681012122 NAD(P) binding site [chemical binding]; other site 288681012123 dimer interface [polypeptide binding]; other site 288681012124 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681012125 substrate binding site [chemical binding]; other site 288681012126 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 288681012127 isocitrate dehydrogenase; Validated; Region: PRK07362 288681012128 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 288681012129 dimer interface [polypeptide binding]; other site 288681012130 Citrate synthase; Region: Citrate_synt; pfam00285 288681012131 active site 288681012132 citrylCoA binding site [chemical binding]; other site 288681012133 oxalacetate/citrate binding site [chemical binding]; other site 288681012134 coenzyme A binding site [chemical binding]; other site 288681012135 catalytic triad [active] 288681012136 Protein of unknown function (DUF441); Region: DUF441; cl01041 288681012137 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 288681012138 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681012139 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 288681012140 pyruvate kinase; Provisional; Region: PRK06354 288681012141 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 288681012142 domain interfaces; other site 288681012143 active site 288681012144 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 288681012145 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 288681012146 active site 288681012147 ADP/pyrophosphate binding site [chemical binding]; other site 288681012148 dimerization interface [polypeptide binding]; other site 288681012149 allosteric effector site; other site 288681012150 fructose-1,6-bisphosphate binding site; other site 288681012151 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 288681012152 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 288681012153 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 288681012154 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 288681012155 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 288681012156 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288681012157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681012158 DNA-binding site [nucleotide binding]; DNA binding site 288681012159 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681012160 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 288681012161 putative NAD(P) binding site [chemical binding]; other site 288681012162 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 288681012163 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 288681012164 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 288681012165 generic binding surface II; other site 288681012166 generic binding surface I; other site 288681012167 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 288681012168 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 288681012169 DHH family; Region: DHH; pfam01368 288681012170 DHHA1 domain; Region: DHHA1; pfam02272 288681012171 YtpI-like protein; Region: YtpI; pfam14007 288681012172 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 288681012173 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 288681012174 active site 288681012175 ATP binding site [chemical binding]; other site 288681012176 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 288681012177 substrate binding site [chemical binding]; other site 288681012178 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 288681012179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681012180 DNA-binding site [nucleotide binding]; DNA binding site 288681012181 DRTGG domain; Region: DRTGG; cl12147 288681012182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 288681012183 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288681012184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681012185 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681012186 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681012187 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681012188 active site 288681012189 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 288681012190 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681012191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681012192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681012193 Coenzyme A binding pocket [chemical binding]; other site 288681012194 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681012195 Cupin domain; Region: Cupin_2; cl09118 288681012196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681012197 non-specific DNA binding site [nucleotide binding]; other site 288681012198 salt bridge; other site 288681012199 sequence-specific DNA binding site [nucleotide binding]; other site 288681012200 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288681012201 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 288681012202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681012204 classical (c) SDRs; Region: SDR_c; cd05233 288681012205 NAD(P) binding site [chemical binding]; other site 288681012206 active site 288681012207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288681012208 Ligand Binding Site [chemical binding]; other site 288681012209 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 288681012210 argininosuccinate lyase; Provisional; Region: PRK00855 288681012211 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 288681012212 active sites [active] 288681012213 tetramer interface [polypeptide binding]; other site 288681012214 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 288681012215 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 288681012216 ANP binding site [chemical binding]; other site 288681012217 Substrate Binding Site II [chemical binding]; other site 288681012218 Substrate Binding Site I [chemical binding]; other site 288681012219 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012220 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012221 EcsC protein family; Region: EcsC; pfam12787 288681012222 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681012223 nudix motif; other site 288681012224 acetate kinase; Region: ackA; TIGR00016 288681012225 Acetokinase family; Region: Acetate_kinase; cl01029 288681012226 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 288681012227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681012228 S-adenosylmethionine binding site [chemical binding]; other site 288681012229 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 288681012230 dimer interface [polypeptide binding]; other site 288681012231 catalytic triad [active] 288681012232 peroxidatic and resolving cysteines [active] 288681012233 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681012234 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681012235 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 288681012236 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 288681012237 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 288681012238 active site 288681012239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681012240 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 288681012241 dimer interface [polypeptide binding]; other site 288681012242 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 288681012243 AMP-binding enzyme; Region: AMP-binding; cl15778 288681012244 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681012245 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681012246 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 288681012247 THUMP domain; Region: THUMP; cl12076 288681012248 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 288681012249 Ligand Binding Site [chemical binding]; other site 288681012250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681012251 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 288681012252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681012253 catalytic residue [active] 288681012254 septation ring formation regulator EzrA; Provisional; Region: PRK04778 288681012255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681012256 Helix-turn-helix domains; Region: HTH; cl00088 288681012257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681012258 dimerization interface [polypeptide binding]; other site 288681012259 EamA-like transporter family; Region: EamA; cl01037 288681012260 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681012261 EamA-like transporter family; Region: EamA; cl01037 288681012262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681012263 Helix-turn-helix domains; Region: HTH; cl00088 288681012264 GAF domain; Region: GAF; cl15785 288681012265 methionine gamma-lyase; Provisional; Region: PRK06767 288681012266 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681012267 homodimer interface [polypeptide binding]; other site 288681012268 substrate-cofactor binding pocket; other site 288681012269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681012270 catalytic residue [active] 288681012271 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 288681012272 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 288681012273 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012274 RNA binding surface [nucleotide binding]; other site 288681012275 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681012276 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681012277 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681012278 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 288681012279 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 288681012280 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 288681012281 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 288681012282 active site 288681012283 HIGH motif; other site 288681012284 dimer interface [polypeptide binding]; other site 288681012285 KMSKS motif; other site 288681012286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012287 RNA binding surface [nucleotide binding]; other site 288681012288 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 288681012289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681012290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681012291 DNA binding residues [nucleotide binding] 288681012292 acetyl-CoA synthetase; Provisional; Region: PRK04319 288681012293 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 288681012294 AMP-binding enzyme; Region: AMP-binding; cl15778 288681012295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681012296 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681012297 FOG: CBS domain [General function prediction only]; Region: COG0517 288681012298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 288681012299 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 288681012300 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 288681012301 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 288681012302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681012303 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012305 active site 288681012306 phosphorylation site [posttranslational modification] 288681012307 intermolecular recognition site; other site 288681012308 dimerization interface [polypeptide binding]; other site 288681012309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012310 DNA binding site [nucleotide binding] 288681012311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681012312 dimerization interface [polypeptide binding]; other site 288681012313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012314 dimer interface [polypeptide binding]; other site 288681012315 phosphorylation site [posttranslational modification] 288681012316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012317 ATP binding site [chemical binding]; other site 288681012318 Mg2+ binding site [ion binding]; other site 288681012319 G-X-G motif; other site 288681012320 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681012321 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681012322 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681012323 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 288681012324 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681012325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012326 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 288681012327 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 288681012328 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 288681012329 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 288681012330 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 288681012331 catabolite control protein A; Region: ccpA; TIGR01481 288681012332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681012333 DNA binding site [nucleotide binding] 288681012334 domain linker motif; other site 288681012335 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 288681012336 dimerization interface [polypeptide binding]; other site 288681012337 effector binding site; other site 288681012338 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 288681012339 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 288681012340 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288681012341 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 288681012342 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 288681012343 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681012344 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681012345 Helix-turn-helix domains; Region: HTH; cl00088 288681012346 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 288681012347 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 288681012348 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681012349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681012350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681012351 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 288681012352 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 288681012353 active site 288681012354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681012355 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 288681012356 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 288681012357 putative tRNA-binding site [nucleotide binding]; other site 288681012358 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 288681012359 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681012360 catalytic residues [active] 288681012361 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 288681012362 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681012363 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 288681012364 oligomer interface [polypeptide binding]; other site 288681012365 active site 288681012366 metal binding site [ion binding]; metal-binding site 288681012367 Predicted small secreted protein [Function unknown]; Region: COG5584 288681012368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681012369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681012370 S-adenosylmethionine binding site [chemical binding]; other site 288681012371 YtzH-like protein; Region: YtzH; pfam14165 288681012372 Phosphotransferase enzyme family; Region: APH; pfam01636 288681012373 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681012374 active site 288681012375 substrate binding site [chemical binding]; other site 288681012376 ATP binding site [chemical binding]; other site 288681012377 pullulanase, type I; Region: pulA_typeI; TIGR02104 288681012378 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 288681012379 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 288681012380 Ca binding site [ion binding]; other site 288681012381 active site 288681012382 catalytic site [active] 288681012383 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 288681012384 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681012385 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681012386 dipeptidase PepV; Reviewed; Region: PRK07318 288681012387 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 288681012388 active site 288681012389 metal binding site [ion binding]; metal-binding site 288681012390 Helix-turn-helix domains; Region: HTH; cl00088 288681012391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681012392 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012393 RNA binding surface [nucleotide binding]; other site 288681012394 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 288681012395 active site 288681012396 uracil binding [chemical binding]; other site 288681012397 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681012398 MatE; Region: MatE; cl10513 288681012399 HI0933-like protein; Region: HI0933_like; pfam03486 288681012400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681012403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012404 putative substrate translocation pore; other site 288681012405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681012406 dimerization interface [polypeptide binding]; other site 288681012407 putative DNA binding site [nucleotide binding]; other site 288681012408 putative Zn2+ binding site [ion binding]; other site 288681012409 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 288681012410 putative hydrophobic ligand binding site [chemical binding]; other site 288681012411 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 288681012412 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 288681012413 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 288681012414 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 288681012415 glucose-1-dehydrogenase; Provisional; Region: PRK08936 288681012416 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 288681012417 NAD binding site [chemical binding]; other site 288681012418 homodimer interface [polypeptide binding]; other site 288681012419 active site 288681012420 Sugar transport protein; Region: Sugar_transport; pfam06800 288681012421 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 288681012422 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 288681012423 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681012424 MoaE interaction surface [polypeptide binding]; other site 288681012425 MoeB interaction surface [polypeptide binding]; other site 288681012426 thiocarboxylated glycine; other site 288681012427 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681012428 MoaE homodimer interface [polypeptide binding]; other site 288681012429 MoaD interaction [polypeptide binding]; other site 288681012430 active site residues [active] 288681012431 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 288681012432 Walker A motif; other site 288681012433 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681012434 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681012435 dimer interface [polypeptide binding]; other site 288681012436 putative functional site; other site 288681012437 putative MPT binding site; other site 288681012438 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 288681012439 trimer interface [polypeptide binding]; other site 288681012440 dimer interface [polypeptide binding]; other site 288681012441 putative active site [active] 288681012442 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681012443 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681012444 ATP binding site [chemical binding]; other site 288681012445 substrate interface [chemical binding]; other site 288681012446 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 288681012447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681012448 FeS/SAM binding site; other site 288681012449 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681012450 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681012451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681012452 active site residue [active] 288681012453 homoserine O-acetyltransferase; Provisional; Region: PRK06765 288681012454 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681012455 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681012456 Spore germination protein; Region: Spore_permease; cl15802 288681012457 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681012458 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 288681012459 putative nucleotide binding site [chemical binding]; other site 288681012460 putative metal binding site [ion binding]; other site 288681012461 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 288681012462 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 288681012463 HIGH motif; other site 288681012464 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288681012465 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 288681012466 active site 288681012467 KMSKS motif; other site 288681012468 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 288681012469 tRNA binding surface [nucleotide binding]; other site 288681012470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681012472 putative substrate translocation pore; other site 288681012473 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681012474 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681012475 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 288681012476 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 288681012477 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 288681012478 Int/Topo IB signature motif; other site 288681012479 FtsX-like permease family; Region: FtsX; cl15850 288681012480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681012481 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681012482 Walker A/P-loop; other site 288681012483 ATP binding site [chemical binding]; other site 288681012484 Q-loop/lid; other site 288681012485 ABC transporter signature motif; other site 288681012486 Walker B; other site 288681012487 D-loop; other site 288681012488 H-loop/switch region; other site 288681012489 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681012490 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681012491 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 288681012492 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 288681012493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681012494 FeS/SAM binding site; other site 288681012495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681012496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681012497 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 288681012498 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681012499 Walker A/P-loop; other site 288681012500 ATP binding site [chemical binding]; other site 288681012501 Q-loop/lid; other site 288681012502 ABC transporter signature motif; other site 288681012503 Walker B; other site 288681012504 D-loop; other site 288681012505 H-loop/switch region; other site 288681012506 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288681012507 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 288681012508 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 288681012509 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 288681012510 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 288681012511 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 288681012512 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 288681012513 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681012514 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681012515 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 288681012516 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 288681012517 trimer interface [polypeptide binding]; other site 288681012518 putative metal binding site [ion binding]; other site 288681012519 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 288681012520 active site 288681012521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681012522 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 288681012523 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 288681012524 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 288681012525 GTP binding site; other site 288681012526 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 288681012527 MPT binding site; other site 288681012528 trimer interface [polypeptide binding]; other site 288681012529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681012530 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681012531 S-adenosylmethionine synthetase; Validated; Region: PRK05250 288681012532 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 288681012533 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 288681012534 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 288681012535 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 288681012536 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 288681012537 active site 288681012538 substrate-binding site [chemical binding]; other site 288681012539 metal-binding site [ion binding] 288681012540 ATP binding site [chemical binding]; other site 288681012541 ATP synthase I chain; Region: ATP_synt_I; cl09170 288681012542 EamA-like transporter family; Region: EamA; cl01037 288681012543 EamA-like transporter family; Region: EamA; cl01037 288681012544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 288681012545 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 288681012546 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681012547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681012548 motif II; other site 288681012549 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681012550 Helix-turn-helix domains; Region: HTH; cl00088 288681012551 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 288681012552 pyrophosphatase PpaX; Provisional; Region: PRK13288 288681012553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681012554 motif II; other site 288681012555 sensory histidine kinase AtoS; Provisional; Region: PRK11360 288681012556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012557 ATP binding site [chemical binding]; other site 288681012558 Mg2+ binding site [ion binding]; other site 288681012559 G-X-G motif; other site 288681012560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012561 dimer interface [polypeptide binding]; other site 288681012562 phosphorylation site [posttranslational modification] 288681012563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012564 ATP binding site [chemical binding]; other site 288681012565 Mg2+ binding site [ion binding]; other site 288681012566 G-X-G motif; other site 288681012567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681012568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681012569 Secretory lipase; Region: LIP; pfam03583 288681012570 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681012571 Sulfatase; Region: Sulfatase; cl10460 288681012572 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 288681012573 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 288681012574 NMT1-like family; Region: NMT1_2; cl15260 288681012575 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681012576 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 288681012577 Walker A/P-loop; other site 288681012578 ATP binding site [chemical binding]; other site 288681012579 Q-loop/lid; other site 288681012580 ABC transporter signature motif; other site 288681012581 Walker B; other site 288681012582 D-loop; other site 288681012583 H-loop/switch region; other site 288681012584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681012585 dimer interface [polypeptide binding]; other site 288681012586 conserved gate region; other site 288681012587 putative PBP binding loops; other site 288681012588 ABC-ATPase subunit interface; other site 288681012589 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 288681012590 active site 288681012591 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 288681012592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681012593 motif II; other site 288681012594 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 288681012595 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 288681012596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 288681012597 nudix motif; other site 288681012598 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 288681012599 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 288681012600 Haemolytic domain; Region: Haemolytic; cl00506 288681012601 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 288681012602 active site clefts [active] 288681012603 zinc binding site [ion binding]; other site 288681012604 dimer interface [polypeptide binding]; other site 288681012605 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 288681012606 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 288681012607 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 288681012608 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681012609 S-layer homology domain; Region: SLH; pfam00395 288681012610 S-layer homology domain; Region: SLH; pfam00395 288681012611 S-layer homology domain; Region: SLH; pfam00395 288681012612 Excalibur calcium-binding domain; Region: Excalibur; cl05460 288681012613 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681012614 putative active site [active] 288681012615 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681012616 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012617 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012618 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681012619 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 288681012620 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 288681012621 Predicted membrane protein [Function unknown]; Region: COG3766 288681012622 PspA/IM30 family; Region: PspA_IM30; pfam04012 288681012623 hypothetical protein; Provisional; Region: PRK06760; cl11698 288681012624 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 288681012625 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 288681012626 G1 box; other site 288681012627 GTP/Mg2+ binding site [chemical binding]; other site 288681012628 Switch I region; other site 288681012629 G2 box; other site 288681012630 G3 box; other site 288681012631 Switch II region; other site 288681012632 G4 box; other site 288681012633 G5 box; other site 288681012634 Nucleoside recognition; Region: Gate; cl00486 288681012635 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 288681012636 Nucleoside recognition; Region: Gate; cl00486 288681012637 FeoA domain; Region: FeoA; cl00838 288681012638 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681012639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681012641 dimerization interface [polypeptide binding]; other site 288681012642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012643 dimer interface [polypeptide binding]; other site 288681012644 phosphorylation site [posttranslational modification] 288681012645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012646 ATP binding site [chemical binding]; other site 288681012647 Mg2+ binding site [ion binding]; other site 288681012648 G-X-G motif; other site 288681012649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012651 active site 288681012652 phosphorylation site [posttranslational modification] 288681012653 intermolecular recognition site; other site 288681012654 dimerization interface [polypeptide binding]; other site 288681012655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012656 DNA binding site [nucleotide binding] 288681012657 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 288681012658 active site 288681012659 catalytic site [active] 288681012660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681012661 active site 288681012662 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 288681012663 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 288681012664 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681012665 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681012666 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 288681012667 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681012668 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681012669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681012670 S-adenosylmethionine binding site [chemical binding]; other site 288681012671 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 288681012672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681012673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681012674 YolD-like protein; Region: YolD; pfam08863 288681012675 FtsX-like permease family; Region: FtsX; cl15850 288681012676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681012677 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681012678 Walker A/P-loop; other site 288681012679 ATP binding site [chemical binding]; other site 288681012680 Q-loop/lid; other site 288681012681 ABC transporter signature motif; other site 288681012682 Walker B; other site 288681012683 D-loop; other site 288681012684 H-loop/switch region; other site 288681012685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681012686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681012687 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681012688 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681012689 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681012690 Walker A/P-loop; other site 288681012691 ATP binding site [chemical binding]; other site 288681012692 Q-loop/lid; other site 288681012693 ABC transporter signature motif; other site 288681012694 Walker B; other site 288681012695 D-loop; other site 288681012696 H-loop/switch region; other site 288681012697 Predicted integral membrane protein [Function unknown]; Region: COG5658 288681012698 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681012699 SdpI/YhfL protein family; Region: SdpI; pfam13630 288681012700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681012701 dimerization interface [polypeptide binding]; other site 288681012702 putative DNA binding site [nucleotide binding]; other site 288681012703 putative Zn2+ binding site [ion binding]; other site 288681012704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012706 active site 288681012707 phosphorylation site [posttranslational modification] 288681012708 intermolecular recognition site; other site 288681012709 dimerization interface [polypeptide binding]; other site 288681012710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012711 DNA binding site [nucleotide binding] 288681012712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 288681012714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012715 ATP binding site [chemical binding]; other site 288681012716 Mg2+ binding site [ion binding]; other site 288681012717 G-X-G motif; other site 288681012718 FtsX-like permease family; Region: FtsX; cl15850 288681012719 FtsX-like permease family; Region: FtsX; cl15850 288681012720 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681012721 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681012722 Walker A/P-loop; other site 288681012723 ATP binding site [chemical binding]; other site 288681012724 Q-loop/lid; other site 288681012725 ABC transporter signature motif; other site 288681012726 Walker B; other site 288681012727 D-loop; other site 288681012728 H-loop/switch region; other site 288681012729 FtsX-like permease family; Region: FtsX; cl15850 288681012730 GntP family permease; Region: GntP_permease; pfam02447 288681012731 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 288681012732 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681012733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681012734 DNA-binding site [nucleotide binding]; DNA binding site 288681012735 UTRA domain; Region: UTRA; cl01230 288681012736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681012737 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681012738 substrate binding site [chemical binding]; other site 288681012739 ATP binding site [chemical binding]; other site 288681012740 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 288681012741 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681012742 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 288681012743 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 288681012744 active site 288681012745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681012746 Helix-turn-helix domains; Region: HTH; cl00088 288681012747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681012748 dimerization interface [polypeptide binding]; other site 288681012749 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681012750 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 288681012751 nucleoside/Zn binding site; other site 288681012752 dimer interface [polypeptide binding]; other site 288681012753 catalytic motif [active] 288681012754 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681012755 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 288681012756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 288681012758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012759 dimer interface [polypeptide binding]; other site 288681012760 phosphorylation site [posttranslational modification] 288681012761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012762 ATP binding site [chemical binding]; other site 288681012763 Mg2+ binding site [ion binding]; other site 288681012764 G-X-G motif; other site 288681012765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012767 active site 288681012768 phosphorylation site [posttranslational modification] 288681012769 intermolecular recognition site; other site 288681012770 dimerization interface [polypeptide binding]; other site 288681012771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012772 DNA binding site [nucleotide binding] 288681012773 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 288681012774 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 288681012775 active site 288681012776 octamer interface [polypeptide binding]; other site 288681012777 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 288681012778 AMP-binding enzyme; Region: AMP-binding; cl15778 288681012779 AMP-binding enzyme; Region: AMP-binding; cl15778 288681012780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681012781 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 288681012782 substrate binding site [chemical binding]; other site 288681012783 oxyanion hole (OAH) forming residues; other site 288681012784 trimer interface [polypeptide binding]; other site 288681012785 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 288681012786 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 288681012787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 288681012788 nucleophilic elbow; other site 288681012789 catalytic triad; other site 288681012790 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 288681012791 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 288681012792 dimer interface [polypeptide binding]; other site 288681012793 tetramer interface [polypeptide binding]; other site 288681012794 PYR/PP interface [polypeptide binding]; other site 288681012795 TPP binding site [chemical binding]; other site 288681012796 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 288681012797 TPP-binding site; other site 288681012798 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 288681012799 chorismate binding enzyme; Region: Chorismate_bind; cl10555 288681012800 UbiA prenyltransferase family; Region: UbiA; cl00337 288681012801 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 288681012802 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681012803 DNA-binding site [nucleotide binding]; DNA binding site 288681012804 RNA-binding motif; other site 288681012805 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 288681012806 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 288681012807 active site flap/lid [active] 288681012808 nucleophilic elbow; other site 288681012809 catalytic triad [active] 288681012810 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 288681012811 homodimer interface [polypeptide binding]; other site 288681012812 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 288681012813 active site pocket [active] 288681012814 glycogen synthase; Provisional; Region: glgA; PRK00654 288681012815 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 288681012816 ADP-binding pocket [chemical binding]; other site 288681012817 homodimer interface [polypeptide binding]; other site 288681012818 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 288681012819 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 288681012820 ligand binding site; other site 288681012821 oligomer interface; other site 288681012822 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 288681012823 dimer interface [polypeptide binding]; other site 288681012824 N-terminal domain interface [polypeptide binding]; other site 288681012825 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 288681012826 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 288681012827 ligand binding site; other site 288681012828 oligomer interface; other site 288681012829 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 288681012830 dimer interface [polypeptide binding]; other site 288681012831 N-terminal domain interface [polypeptide binding]; other site 288681012832 sulfate 1 binding site; other site 288681012833 glycogen branching enzyme; Provisional; Region: PRK12313 288681012834 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 288681012835 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 288681012836 active site 288681012837 catalytic site [active] 288681012838 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 288681012839 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681012840 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681012841 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681012842 putative active site [active] 288681012843 catalytic triad [active] 288681012844 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 288681012845 PA/protease domain interface [polypeptide binding]; other site 288681012846 putative integrin binding motif; other site 288681012847 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681012848 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 288681012849 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 288681012850 dockerin binding interface; other site 288681012851 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681012852 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681012853 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681012854 NAD binding site [chemical binding]; other site 288681012855 dimer interface [polypeptide binding]; other site 288681012856 substrate binding site [chemical binding]; other site 288681012857 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 288681012858 MgtC family; Region: MgtC; pfam02308 288681012859 Ion channel; Region: Ion_trans_2; cl11596 288681012860 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681012861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012862 YugN-like family; Region: YugN; pfam08868 288681012863 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 288681012864 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 288681012865 active site 288681012866 dimer interface [polypeptide binding]; other site 288681012867 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 288681012868 dimer interface [polypeptide binding]; other site 288681012869 active site 288681012870 Domain of unknown function (DUF378); Region: DUF378; cl00943 288681012871 general stress protein 13; Validated; Region: PRK08059 288681012872 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 288681012873 RNA binding site [nucleotide binding]; other site 288681012874 hypothetical protein; Validated; Region: PRK07682 288681012875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681012876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681012877 homodimer interface [polypeptide binding]; other site 288681012878 catalytic residue [active] 288681012879 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 288681012880 AsnC family; Region: AsnC_trans_reg; pfam01037 288681012881 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 288681012882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012883 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 288681012884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681012885 nucleophilic elbow; other site 288681012886 catalytic triad; other site 288681012887 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 288681012888 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 288681012889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681012890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681012891 homodimer interface [polypeptide binding]; other site 288681012892 catalytic residue [active] 288681012893 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 288681012894 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 288681012895 E-class dimer interface [polypeptide binding]; other site 288681012896 P-class dimer interface [polypeptide binding]; other site 288681012897 active site 288681012898 Cu2+ binding site [ion binding]; other site 288681012899 Zn2+ binding site [ion binding]; other site 288681012900 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 288681012901 Kinase associated protein B; Region: KapB; pfam08810 288681012902 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 288681012903 active site 288681012904 catalytic site [active] 288681012905 substrate binding site [chemical binding]; other site 288681012906 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288681012907 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 288681012908 transmembrane helices; other site 288681012909 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681012910 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 288681012911 active site 288681012912 glycyl-tRNA synthetase; Provisional; Region: PRK04173 288681012913 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 288681012914 motif 1; other site 288681012915 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 288681012916 active site 288681012917 motif 2; other site 288681012918 motif 3; other site 288681012919 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 288681012920 anticodon binding site; other site 288681012921 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288681012922 CoenzymeA binding site [chemical binding]; other site 288681012923 subunit interaction site [polypeptide binding]; other site 288681012924 PHB binding site; other site 288681012925 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 288681012926 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 288681012927 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681012928 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 288681012929 active site 288681012930 tetramer interface; other site 288681012931 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 288681012932 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 288681012933 active site 288681012934 substrate binding site [chemical binding]; other site 288681012935 metal binding site [ion binding]; metal-binding site 288681012936 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 288681012937 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681012938 multifunctional aminopeptidase A; Provisional; Region: PRK00913 288681012939 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 288681012940 interface (dimer of trimers) [polypeptide binding]; other site 288681012941 Substrate-binding/catalytic site; other site 288681012942 Zn-binding sites [ion binding]; other site 288681012943 3D domain; Region: 3D; cl01439 288681012944 Putative membrane protein; Region: YuiB; pfam14068 288681012945 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681012946 nudix motif; other site 288681012947 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681012948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681012949 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 288681012950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681012951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681012952 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012953 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012954 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012955 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012956 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012957 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012958 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012959 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012960 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012961 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012962 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012963 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012964 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012965 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012966 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012967 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012968 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012969 Fibronectin type III-like domain; Region: Fn3-like; cl15273 288681012970 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681012971 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681012972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012973 putative substrate translocation pore; other site 288681012974 Helix-turn-helix domains; Region: HTH; cl00088 288681012975 Protein of unknown function (DUF523); Region: DUF523; cl00733 288681012976 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681012977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681012978 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681012979 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 288681012980 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 288681012981 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681012982 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681012983 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 288681012984 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681012985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681012986 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681012987 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 288681012988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681012989 Walker A/P-loop; other site 288681012990 ATP binding site [chemical binding]; other site 288681012991 Q-loop/lid; other site 288681012992 ABC transporter signature motif; other site 288681012993 Walker B; other site 288681012994 D-loop; other site 288681012995 H-loop/switch region; other site 288681012996 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 288681012997 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 288681012998 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 288681012999 PhnA protein; Region: PhnA; pfam03831 288681013000 CAAX protease self-immunity; Region: Abi; cl00558 288681013001 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681013002 active site 288681013003 NTP binding site [chemical binding]; other site 288681013004 metal binding triad [ion binding]; metal-binding site 288681013005 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 288681013006 NifU-like domain; Region: NifU; cl00484 288681013007 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681013008 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 288681013009 tetramer interfaces [polypeptide binding]; other site 288681013010 binuclear metal-binding site [ion binding]; other site 288681013011 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681013012 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681013013 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 288681013014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013015 active site 288681013016 motif I; other site 288681013017 motif II; other site 288681013018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013019 Predicted transcriptional regulator [Transcription]; Region: COG2345 288681013020 Helix-turn-helix domains; Region: HTH; cl00088 288681013021 Protein of unknown function DUF86; Region: DUF86; cl01031 288681013022 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 288681013023 putative active site [active] 288681013024 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 288681013025 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 288681013026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 288681013027 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 288681013028 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681013029 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681013030 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681013031 DNA binding residues [nucleotide binding] 288681013032 dimer interface [polypeptide binding]; other site 288681013033 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681013034 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 288681013035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681013036 catalytic core [active] 288681013037 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 288681013038 putative deacylase active site [active] 288681013039 lipoyl synthase; Provisional; Region: PRK05481 288681013040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681013041 FeS/SAM binding site; other site 288681013042 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681013043 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 288681013044 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 288681013045 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 288681013046 active site 288681013047 metal binding site [ion binding]; metal-binding site 288681013048 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681013049 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 288681013050 FeS assembly protein SufB; Region: sufB; TIGR01980 288681013051 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 288681013052 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 288681013053 trimerization site [polypeptide binding]; other site 288681013054 active site 288681013055 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 288681013056 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 288681013057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681013058 catalytic residue [active] 288681013059 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 288681013060 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 288681013061 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 288681013062 FeS assembly ATPase SufC; Region: sufC; TIGR01978 288681013063 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 288681013064 Walker A/P-loop; other site 288681013065 ATP binding site [chemical binding]; other site 288681013066 Q-loop/lid; other site 288681013067 ABC transporter signature motif; other site 288681013068 Walker B; other site 288681013069 D-loop; other site 288681013070 H-loop/switch region; other site 288681013071 NMT1-like family; Region: NMT1_2; cl15260 288681013072 NMT1-like family; Region: NMT1_2; cl15260 288681013073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681013074 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288681013075 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 288681013076 Walker A/P-loop; other site 288681013077 ATP binding site [chemical binding]; other site 288681013078 Q-loop/lid; other site 288681013079 ABC transporter signature motif; other site 288681013080 Walker B; other site 288681013081 D-loop; other site 288681013082 H-loop/switch region; other site 288681013083 NIL domain; Region: NIL; cl09633 288681013084 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681013085 catalytic residues [active] 288681013086 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 288681013087 putative active site [active] 288681013088 putative metal binding site [ion binding]; other site 288681013089 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 288681013090 lipoyl attachment site [posttranslational modification]; other site 288681013091 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 288681013092 ArsC family; Region: ArsC; pfam03960 288681013093 putative ArsC-like catalytic residues; other site 288681013094 putative TRX-like catalytic residues [active] 288681013095 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 288681013096 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 288681013097 active site 288681013098 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681013099 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 288681013100 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681013101 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681013102 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681013103 NAD binding site [chemical binding]; other site 288681013104 dimer interface [polypeptide binding]; other site 288681013105 substrate binding site [chemical binding]; other site 288681013106 Coat F domain; Region: Coat_F; cl15836 288681013107 CAAX protease self-immunity; Region: Abi; cl00558 288681013108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013109 non-specific DNA binding site [nucleotide binding]; other site 288681013110 salt bridge; other site 288681013111 sequence-specific DNA binding site [nucleotide binding]; other site 288681013112 Helix-turn-helix domains; Region: HTH; cl00088 288681013113 WHG domain; Region: WHG; pfam13305 288681013114 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288681013115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681013116 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681013117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681013118 active site 288681013119 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 288681013120 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681013121 dimer interface [polypeptide binding]; other site 288681013122 active site 288681013123 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 288681013124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013125 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681013126 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 288681013127 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681013128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681013129 substrate binding site [chemical binding]; other site 288681013130 oxyanion hole (OAH) forming residues; other site 288681013131 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681013132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681013133 Proline dehydrogenase; Region: Pro_dh; cl03282 288681013134 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 288681013135 Domain of unknown function DUF77; Region: DUF77; cl00307 288681013136 Cache domain; Region: Cache_1; pfam02743 288681013137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013138 dimerization interface [polypeptide binding]; other site 288681013139 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 288681013140 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013142 dimer interface [polypeptide binding]; other site 288681013143 putative CheW interface [polypeptide binding]; other site 288681013144 Helix-turn-helix domains; Region: HTH; cl00088 288681013145 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681013146 C-terminal domain interface [polypeptide binding]; other site 288681013147 sugar binding site [chemical binding]; other site 288681013148 TQXA domain; Region: TQXA_dom; TIGR03934 288681013149 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681013150 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681013151 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681013152 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681013153 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681013154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013155 putative substrate translocation pore; other site 288681013156 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 288681013157 Spore germination protein; Region: Spore_permease; cl15802 288681013158 MAEBL; Provisional; Region: PTZ00121 288681013159 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 288681013160 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681013161 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681013162 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 288681013163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681013164 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681013165 Protein of unknown function (DUF3938); Region: DUF3938; cl07999 288681013166 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 288681013167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013168 dimerization interface [polypeptide binding]; other site 288681013169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013170 dimer interface [polypeptide binding]; other site 288681013171 phosphorylation site [posttranslational modification] 288681013172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013173 ATP binding site [chemical binding]; other site 288681013174 Mg2+ binding site [ion binding]; other site 288681013175 G-X-G motif; other site 288681013176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013178 active site 288681013179 phosphorylation site [posttranslational modification] 288681013180 intermolecular recognition site; other site 288681013181 dimerization interface [polypeptide binding]; other site 288681013182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013183 DNA binding site [nucleotide binding] 288681013184 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681013185 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681013186 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 288681013187 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681013188 Walker A/P-loop; other site 288681013189 ATP binding site [chemical binding]; other site 288681013190 Q-loop/lid; other site 288681013191 ABC transporter signature motif; other site 288681013192 Walker B; other site 288681013193 D-loop; other site 288681013194 H-loop/switch region; other site 288681013195 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 288681013196 active site 288681013197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013198 non-specific DNA binding site [nucleotide binding]; other site 288681013199 salt bridge; other site 288681013200 sequence-specific DNA binding site [nucleotide binding]; other site 288681013201 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681013202 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 288681013203 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 288681013204 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013206 active site 288681013207 phosphorylation site [posttranslational modification] 288681013208 intermolecular recognition site; other site 288681013209 dimerization interface [polypeptide binding]; other site 288681013210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013211 DNA binding site [nucleotide binding] 288681013212 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 288681013213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013214 dimer interface [polypeptide binding]; other site 288681013215 phosphorylation site [posttranslational modification] 288681013216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013217 ATP binding site [chemical binding]; other site 288681013218 Mg2+ binding site [ion binding]; other site 288681013219 G-X-G motif; other site 288681013220 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 288681013221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681013222 S-adenosylmethionine binding site [chemical binding]; other site 288681013223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013224 dimerization interface [polypeptide binding]; other site 288681013225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013228 dimer interface [polypeptide binding]; other site 288681013229 putative CheW interface [polypeptide binding]; other site 288681013230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013231 dimerization interface [polypeptide binding]; other site 288681013232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013233 dimer interface [polypeptide binding]; other site 288681013234 putative CheW interface [polypeptide binding]; other site 288681013235 Domain of unknown function DUF59; Region: DUF59; cl00941 288681013236 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681013237 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 288681013238 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681013239 active site 288681013240 Zn binding site [ion binding]; other site 288681013241 Cupin domain; Region: Cupin_2; cl09118 288681013242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681013243 Helix-turn-helix domains; Region: HTH; cl00088 288681013244 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 288681013245 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681013246 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681013247 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 288681013248 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 288681013249 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013250 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681013251 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 288681013252 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 288681013253 dimerization interface [polypeptide binding]; other site 288681013254 DPS ferroxidase diiron center [ion binding]; other site 288681013255 ion pore; other site 288681013256 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 288681013257 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 288681013258 metal binding site [ion binding]; metal-binding site 288681013259 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 288681013260 Ferritin-like domain; Region: Ferritin; pfam00210 288681013261 ferroxidase diiron center [ion binding]; other site 288681013262 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681013263 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681013264 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681013265 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681013266 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681013267 Nucleoside recognition; Region: Gate; cl00486 288681013268 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681013269 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013270 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681013271 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013272 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681013273 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681013274 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681013275 NAD binding site [chemical binding]; other site 288681013276 substrate binding site [chemical binding]; other site 288681013277 putative active site [active] 288681013278 Peptidase M60-like family; Region: M60-like; pfam13402 288681013279 Viral enhancin protein; Region: Enhancin; pfam03272 288681013280 TQXA domain; Region: TQXA_dom; TIGR03934 288681013281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681013282 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681013283 active site 288681013284 catalytic tetrad [active] 288681013285 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681013286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013287 putative substrate translocation pore; other site 288681013288 Helix-turn-helix domains; Region: HTH; cl00088 288681013289 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 288681013290 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681013291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013292 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 288681013293 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 288681013294 active site 288681013295 HIGH motif; other site 288681013296 dimer interface [polypeptide binding]; other site 288681013297 KMSKS motif; other site 288681013298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681013299 RNA binding surface [nucleotide binding]; other site 288681013300 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 288681013301 FAD binding domain; Region: FAD_binding_4; pfam01565 288681013302 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 288681013303 SET domain; Region: SET; cl02566 288681013304 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 288681013305 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013306 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013307 dimer interface [polypeptide binding]; other site 288681013308 putative CheW interface [polypeptide binding]; other site 288681013309 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288681013310 putative phosphate binding site [ion binding]; other site 288681013311 CrcB-like protein; Region: CRCB; cl09114 288681013312 CrcB-like protein; Region: CRCB; cl09114 288681013313 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 288681013314 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 288681013315 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 288681013316 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681013317 Phosphate-starvation-inducible E; Region: PsiE; cl01264 288681013318 Restriction endonuclease; Region: Mrr_cat; cl00516 288681013319 Helix-turn-helix domains; Region: HTH; cl00088 288681013320 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 288681013321 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681013322 Walker A/P-loop; other site 288681013323 ATP binding site [chemical binding]; other site 288681013324 Q-loop/lid; other site 288681013325 ABC transporter signature motif; other site 288681013326 Walker B; other site 288681013327 D-loop; other site 288681013328 H-loop/switch region; other site 288681013329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681013330 ABC-ATPase subunit interface; other site 288681013331 dimer interface [polypeptide binding]; other site 288681013332 putative PBP binding regions; other site 288681013333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681013334 ABC-ATPase subunit interface; other site 288681013335 dimer interface [polypeptide binding]; other site 288681013336 putative PBP binding regions; other site 288681013337 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 288681013338 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 288681013339 putative ligand binding residues [chemical binding]; other site 288681013340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013342 active site 288681013343 phosphorylation site [posttranslational modification] 288681013344 intermolecular recognition site; other site 288681013345 dimerization interface [polypeptide binding]; other site 288681013346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013347 DNA binding site [nucleotide binding] 288681013348 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 288681013349 SmpB-tmRNA interface; other site 288681013350 ribonuclease R; Region: RNase_R; TIGR02063 288681013351 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681013352 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681013353 RNB domain; Region: RNB; pfam00773 288681013354 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 288681013355 RNA binding site [nucleotide binding]; other site 288681013356 Esterase/lipase [General function prediction only]; Region: COG1647 288681013357 Preprotein translocase SecG subunit; Region: SecG; cl09123 288681013358 LrgB-like family; Region: LrgB; cl00596 288681013359 LrgA family; Region: LrgA; cl00608 288681013360 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681013361 active site 288681013362 enolase; Provisional; Region: eno; PRK00077 288681013363 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 288681013364 dimer interface [polypeptide binding]; other site 288681013365 metal binding site [ion binding]; metal-binding site 288681013366 substrate binding pocket [chemical binding]; other site 288681013367 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 288681013368 Sulfatase; Region: Sulfatase; cl10460 288681013369 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 288681013370 substrate binding site [chemical binding]; other site 288681013371 dimer interface [polypeptide binding]; other site 288681013372 catalytic triad [active] 288681013373 Phosphoglycerate kinase; Region: PGK; pfam00162 288681013374 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 288681013375 substrate binding site [chemical binding]; other site 288681013376 hinge regions; other site 288681013377 ADP binding site [chemical binding]; other site 288681013378 catalytic site [active] 288681013379 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 288681013380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013381 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 288681013382 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681013383 Predicted transcriptional regulator [Transcription]; Region: COG3388 288681013384 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681013385 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 288681013386 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 288681013387 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 288681013388 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 288681013389 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 288681013390 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 288681013391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681013392 TPR motif; other site 288681013393 binding surface 288681013394 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681013395 SpoVA protein; Region: SpoVA; cl04298 288681013396 stage V sporulation protein AD; Provisional; Region: PRK12404 288681013397 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 288681013398 SpoVA protein; Region: SpoVA; cl04298 288681013399 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681013400 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681013401 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681013402 Clp protease; Region: CLP_protease; pfam00574 288681013403 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288681013404 oligomer interface [polypeptide binding]; other site 288681013405 active site residues [active] 288681013406 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288681013407 dimerization domain swap beta strand [polypeptide binding]; other site 288681013408 regulatory protein interface [polypeptide binding]; other site 288681013409 active site 288681013410 regulatory phosphorylation site [posttranslational modification]; other site 288681013411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 288681013412 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 288681013413 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 288681013414 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 288681013415 phosphate binding site [ion binding]; other site 288681013416 putative substrate binding pocket [chemical binding]; other site 288681013417 dimer interface [polypeptide binding]; other site 288681013418 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 288681013419 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 288681013420 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681013421 putative active site [active] 288681013422 nucleotide binding site [chemical binding]; other site 288681013423 nudix motif; other site 288681013424 putative metal binding site [ion binding]; other site 288681013425 Domain of unknown function (DUF368); Region: DUF368; cl00893 288681013426 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 288681013427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681013430 binding surface 288681013431 TPR motif; other site 288681013432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681013433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681013434 binding surface 288681013435 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681013436 TPR motif; other site 288681013437 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 288681013438 trimer interface [polypeptide binding]; other site 288681013439 active site 288681013440 substrate binding site [chemical binding]; other site 288681013441 CoA binding site [chemical binding]; other site 288681013442 pyrophosphatase PpaX; Provisional; Region: PRK13288 288681013443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013444 active site 288681013445 motif I; other site 288681013446 motif II; other site 288681013447 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 288681013448 HPr kinase/phosphorylase; Provisional; Region: PRK05428 288681013449 DRTGG domain; Region: DRTGG; cl12147 288681013450 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 288681013451 Hpr binding site; other site 288681013452 active site 288681013453 homohexamer subunit interaction site [polypeptide binding]; other site 288681013454 Membrane protein of unknown function; Region: DUF360; cl00850 288681013455 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 288681013456 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 288681013457 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 288681013458 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 288681013459 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 288681013460 excinuclease ABC subunit B; Provisional; Region: PRK05298 288681013461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681013462 ATP binding site [chemical binding]; other site 288681013463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681013464 nucleotide binding region [chemical binding]; other site 288681013465 ATP-binding site [chemical binding]; other site 288681013466 Ultra-violet resistance protein B; Region: UvrB; pfam12344 288681013467 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681013468 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681013469 DNA binding residues [nucleotide binding] 288681013470 dimer interface [polypeptide binding]; other site 288681013471 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681013472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013473 non-specific DNA binding site [nucleotide binding]; other site 288681013474 salt bridge; other site 288681013475 sequence-specific DNA binding site [nucleotide binding]; other site 288681013476 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 288681013477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681013478 Helix-turn-helix domains; Region: HTH; cl00088 288681013479 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 288681013480 putative dimerization interface [polypeptide binding]; other site 288681013481 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 288681013482 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681013483 DNA binding residues [nucleotide binding] 288681013484 putative dimer interface [polypeptide binding]; other site 288681013485 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681013486 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 288681013487 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681013488 ABC transporter; Region: ABC_tran_2; pfam12848 288681013489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681013490 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681013491 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 288681013492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681013493 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681013494 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 288681013495 Walker A/P-loop; other site 288681013496 ATP binding site [chemical binding]; other site 288681013497 Q-loop/lid; other site 288681013498 ABC transporter signature motif; other site 288681013499 Walker B; other site 288681013500 D-loop; other site 288681013501 H-loop/switch region; other site 288681013502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681013503 protein binding site [polypeptide binding]; other site 288681013504 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 288681013505 C-terminal peptidase (prc); Region: prc; TIGR00225 288681013506 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 288681013507 protein binding site [polypeptide binding]; other site 288681013508 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 288681013509 Catalytic dyad [active] 288681013510 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 288681013511 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 288681013512 FtsX-like permease family; Region: FtsX; cl15850 288681013513 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 288681013514 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681013515 Walker A/P-loop; other site 288681013516 ATP binding site [chemical binding]; other site 288681013517 Q-loop/lid; other site 288681013518 ABC transporter signature motif; other site 288681013519 Walker B; other site 288681013520 D-loop; other site 288681013521 H-loop/switch region; other site 288681013522 Cytochrome c; Region: Cytochrom_C; cl11414 288681013523 peptide chain release factor 2; Provisional; Region: PRK06746 288681013524 RF-1 domain; Region: RF-1; cl02875 288681013525 RF-1 domain; Region: RF-1; cl02875 288681013526 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 288681013527 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 288681013528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681013529 nucleotide binding region [chemical binding]; other site 288681013530 ATP-binding site [chemical binding]; other site 288681013531 SEC-C motif; Region: SEC-C; pfam02810 288681013532 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 288681013533 30S subunit binding site; other site 288681013534 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 288681013535 DNA-binding site [nucleotide binding]; DNA binding site 288681013536 RNA-binding motif; other site 288681013537 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 288681013538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681013539 active site 288681013540 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 288681013541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681013542 ATP binding site [chemical binding]; other site 288681013543 putative Mg++ binding site [ion binding]; other site 288681013544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681013545 nucleotide binding region [chemical binding]; other site 288681013546 ATP-binding site [chemical binding]; other site 288681013547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681013548 NlpC/P60 family; Region: NLPC_P60; cl11438 288681013549 Helix-turn-helix domains; Region: HTH; cl00088 288681013550 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 288681013551 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 288681013552 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 288681013553 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 288681013554 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681013555 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 288681013556 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 288681013557 active site 288681013558 homodimer interface [polypeptide binding]; other site 288681013559 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 288681013560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013561 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681013562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013563 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 288681013564 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 288681013565 Mg++ binding site [ion binding]; other site 288681013566 putative catalytic motif [active] 288681013567 substrate binding site [chemical binding]; other site 288681013568 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681013569 NodB motif; other site 288681013570 active site 288681013571 catalytic site [active] 288681013572 Zn binding site [ion binding]; other site 288681013573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681013574 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681013575 Walker A motif; other site 288681013576 ATP binding site [chemical binding]; other site 288681013577 Walker B motif; other site 288681013578 arginine finger; other site 288681013579 Transcriptional antiterminator [Transcription]; Region: COG3933 288681013580 PRD domain; Region: PRD; cl15445 288681013581 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 288681013582 active pocket/dimerization site; other site 288681013583 active site 288681013584 phosphorylation site [posttranslational modification] 288681013585 PRD domain; Region: PRD; cl15445 288681013586 CHRD domain; Region: CHRD; cl06473 288681013587 Chromate transporter; Region: Chromate_transp; pfam02417 288681013588 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 288681013589 Chromate transporter; Region: Chromate_transp; pfam02417 288681013590 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 288681013591 putative active site [active] 288681013592 YdjC motif; other site 288681013593 Mg binding site [ion binding]; other site 288681013594 putative homodimer interface [polypeptide binding]; other site 288681013595 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 288681013596 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 288681013597 NAD binding site [chemical binding]; other site 288681013598 sugar binding site [chemical binding]; other site 288681013599 divalent metal binding site [ion binding]; other site 288681013600 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681013601 dimer interface [polypeptide binding]; other site 288681013602 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681013603 active site 288681013604 methionine cluster; other site 288681013605 phosphorylation site [posttranslational modification] 288681013606 metal binding site [ion binding]; metal-binding site 288681013607 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681013608 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681013609 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681013610 active site 288681013611 P-loop; other site 288681013612 phosphorylation site [posttranslational modification] 288681013613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681013614 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 288681013615 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681013616 methionine cluster; other site 288681013617 active site 288681013618 phosphorylation site [posttranslational modification] 288681013619 metal binding site [ion binding]; metal-binding site 288681013620 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681013621 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681013622 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681013623 active site 288681013624 P-loop; other site 288681013625 phosphorylation site [posttranslational modification] 288681013626 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681013627 Acyltransferase family; Region: Acyl_transf_3; pfam01757 288681013628 OpgC protein; Region: OpgC_C; cl00792 288681013629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681013630 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288681013631 Predicted membrane protein [Function unknown]; Region: COG1511 288681013632 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681013633 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681013634 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 288681013635 Helix-turn-helix domains; Region: HTH; cl00088 288681013636 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 288681013637 putative dimerization interface [polypeptide binding]; other site 288681013638 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 288681013639 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 288681013640 arsenical pump membrane protein; Provisional; Region: PRK15445 288681013641 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 288681013642 transmembrane helices; other site 288681013643 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 288681013644 ThiC-associated domain; Region: ThiC-associated; pfam13667 288681013645 ThiC family; Region: ThiC; cl08031 288681013646 L-lactate permease; Region: Lactate_perm; cl00701 288681013647 Transposase; Region: DDE_Tnp_ISL3; pfam01610 288681013648 L-lactate permease; Region: Lactate_perm; cl00701 288681013649 glycolate transporter; Provisional; Region: PRK09695 288681013650 Tic20-like protein; Region: Tic20; pfam09685 288681013651 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 288681013652 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 288681013653 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681013654 Sulfatase; Region: Sulfatase; cl10460 288681013655 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681013656 homodimer interface [polypeptide binding]; other site 288681013657 substrate-cofactor binding pocket; other site 288681013658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681013659 catalytic residue [active] 288681013660 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 288681013661 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013662 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013663 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013664 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013665 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013666 NlpC/P60 family; Region: NLPC_P60; cl11438 288681013667 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681013668 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681013669 Nucleoside recognition; Region: Gate; cl00486 288681013670 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681013671 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 288681013672 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 288681013673 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 288681013674 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 288681013675 DXD motif; other site 288681013676 BCCT family transporter; Region: BCCT; cl00569 288681013677 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013678 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013679 3D domain; Region: 3D; cl01439 288681013680 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 288681013681 Predicted membrane protein [Function unknown]; Region: COG4640 288681013682 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 288681013683 Double zinc ribbon; Region: DZR; pfam12773 288681013684 Double zinc ribbon; Region: DZR; pfam12773 288681013685 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 288681013686 SNF2 Helicase protein; Region: DUF3670; pfam12419 288681013687 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 288681013688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681013689 ATP binding site [chemical binding]; other site 288681013690 putative Mg++ binding site [ion binding]; other site 288681013691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681013692 nucleotide binding region [chemical binding]; other site 288681013693 ATP-binding site [chemical binding]; other site 288681013694 VanZ like family; Region: VanZ; cl01971 288681013695 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 288681013696 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 288681013697 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 288681013698 ComK protein; Region: ComK; cl11560 288681013699 RNA polymerase factor sigma-70; Validated; Region: PRK06759 288681013700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681013701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681013702 DNA binding residues [nucleotide binding] 288681013703 Yip1 domain; Region: Yip1; cl12048 288681013704 Yip1 domain; Region: Yip1; cl12048 288681013705 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681013706 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681013707 FtsX-like permease family; Region: FtsX; cl15850 288681013708 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681013709 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681013710 Walker A/P-loop; other site 288681013711 ATP binding site [chemical binding]; other site 288681013712 Q-loop/lid; other site 288681013713 ABC transporter signature motif; other site 288681013714 Walker B; other site 288681013715 D-loop; other site 288681013716 H-loop/switch region; other site 288681013717 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 288681013718 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 288681013719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013720 non-specific DNA binding site [nucleotide binding]; other site 288681013721 salt bridge; other site 288681013722 sequence-specific DNA binding site [nucleotide binding]; other site 288681013723 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 288681013724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013725 putative substrate translocation pore; other site 288681013726 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 288681013727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681013728 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 288681013729 sensory histidine kinase CreC; Provisional; Region: PRK11100 288681013730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013731 dimerization interface [polypeptide binding]; other site 288681013732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013733 dimer interface [polypeptide binding]; other site 288681013734 phosphorylation site [posttranslational modification] 288681013735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013736 ATP binding site [chemical binding]; other site 288681013737 Mg2+ binding site [ion binding]; other site 288681013738 G-X-G motif; other site 288681013739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013741 active site 288681013742 phosphorylation site [posttranslational modification] 288681013743 intermolecular recognition site; other site 288681013744 dimerization interface [polypeptide binding]; other site 288681013745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013746 DNA binding site [nucleotide binding] 288681013747 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 288681013748 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 288681013749 NAD binding site [chemical binding]; other site 288681013750 homodimer interface [polypeptide binding]; other site 288681013751 active site 288681013752 substrate binding site [chemical binding]; other site 288681013753 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681013754 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 288681013755 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 288681013756 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 288681013757 active site 288681013758 homodimer interface [polypeptide binding]; other site 288681013759 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 288681013760 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 288681013761 Walker A/P-loop; other site 288681013762 ATP binding site [chemical binding]; other site 288681013763 Q-loop/lid; other site 288681013764 ABC transporter signature motif; other site 288681013765 Walker B; other site 288681013766 D-loop; other site 288681013767 H-loop/switch region; other site 288681013768 Bacterial SH3 domain; Region: SH3_3; cl02551 288681013769 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681013770 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 288681013771 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681013772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013773 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 288681013774 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 288681013775 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681013776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 288681013777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681013778 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681013779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681013780 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 288681013781 rod shape-determining protein Mbl; Provisional; Region: PRK13928 288681013782 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 288681013783 ATP binding site [chemical binding]; other site 288681013784 profilin binding site; other site 288681013785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 288681013786 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 288681013787 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 288681013788 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 288681013789 active site 288681013790 CoA binding site [chemical binding]; other site 288681013791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681013792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 288681013793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681013794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681013795 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681013796 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681013797 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681013798 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681013799 Walker A/P-loop; other site 288681013800 ATP binding site [chemical binding]; other site 288681013801 Q-loop/lid; other site 288681013802 ABC transporter signature motif; other site 288681013803 Walker B; other site 288681013804 D-loop; other site 288681013805 H-loop/switch region; other site 288681013806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681013807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681013808 Walker A/P-loop; other site 288681013809 ATP binding site [chemical binding]; other site 288681013810 Q-loop/lid; other site 288681013811 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681013812 ABC transporter signature motif; other site 288681013813 Walker B; other site 288681013814 D-loop; other site 288681013815 H-loop/switch region; other site 288681013816 LytTr DNA-binding domain; Region: LytTR; cl04498 288681013817 stage II sporulation protein D; Region: spore_II_D; TIGR02870 288681013818 Stage II sporulation protein; Region: SpoIID; pfam08486 288681013819 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 288681013820 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 288681013821 hinge; other site 288681013822 active site 288681013823 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 288681013824 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 288681013825 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 288681013826 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 288681013827 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 288681013828 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 288681013829 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 288681013830 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 288681013831 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 288681013832 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 288681013833 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 288681013834 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 288681013835 4Fe-4S binding domain; Region: Fer4; cl02805 288681013836 4Fe-4S binding domain; Region: Fer4; cl02805 288681013837 NADH dehydrogenase; Region: NADHdh; cl00469 288681013838 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 288681013839 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 288681013840 NADH dehydrogenase subunit C; Validated; Region: PRK07735 288681013841 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 288681013842 NADH dehydrogenase subunit B; Validated; Region: PRK06411 288681013843 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 288681013844 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 288681013845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681013846 PAS domain; Region: PAS_9; pfam13426 288681013847 putative active site [active] 288681013848 heme pocket [chemical binding]; other site 288681013849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681013850 metal binding site [ion binding]; metal-binding site 288681013851 active site 288681013852 I-site; other site 288681013853 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681013854 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681013855 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681013856 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 288681013857 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 288681013858 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 288681013859 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 288681013860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 288681013861 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 288681013862 alpha subunit interaction interface [polypeptide binding]; other site 288681013863 Walker A motif; other site 288681013864 ATP binding site [chemical binding]; other site 288681013865 Walker B motif; other site 288681013866 inhibitor binding site; inhibition site 288681013867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288681013868 ATP synthase; Region: ATP-synt; cl00365 288681013869 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 288681013870 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 288681013871 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 288681013872 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 288681013873 beta subunit interaction interface [polypeptide binding]; other site 288681013874 Walker A motif; other site 288681013875 ATP binding site [chemical binding]; other site 288681013876 Walker B motif; other site 288681013877 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288681013878 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 288681013879 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 288681013880 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 288681013881 ATP synthase subunit C; Region: ATP-synt_C; cl00466 288681013882 ATP synthase A chain; Region: ATP-synt_A; cl00413 288681013883 ATP synthase I chain; Region: ATP_synt_I; cl09170 288681013884 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 288681013885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681013886 active site 288681013887 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 288681013888 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 288681013889 dimer interface [polypeptide binding]; other site 288681013890 active site 288681013891 glycine-pyridoxal phosphate binding site [chemical binding]; other site 288681013892 folate binding site [chemical binding]; other site 288681013893 Protein of unknown function (DUF436); Region: DUF436; cl01860 288681013894 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 288681013895 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681013896 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 288681013897 active site 288681013898 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 288681013899 HPr interaction site; other site 288681013900 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681013901 active site 288681013902 phosphorylation site [posttranslational modification] 288681013903 DoxX; Region: DoxX; cl00976 288681013904 Flavin Reductases; Region: FlaRed; cl00801 288681013905 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 288681013906 Domain of unknown function DUF; Region: DUF204; pfam02659 288681013907 Domain of unknown function DUF; Region: DUF204; pfam02659 288681013908 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 288681013909 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 288681013910 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681013911 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 288681013912 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 288681013913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681013914 S-adenosylmethionine binding site [chemical binding]; other site 288681013915 peptide chain release factor 1; Validated; Region: prfA; PRK00591 288681013916 RF-1 domain; Region: RF-1; cl02875 288681013917 RF-1 domain; Region: RF-1; cl02875 288681013918 thymidine kinase; Provisional; Region: PRK04296 288681013919 LabA_like proteins; Region: LabA_like/DUF88; cl10034 288681013920 putative metal binding site [ion binding]; other site 288681013921 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 288681013922 transcription termination factor Rho; Provisional; Region: rho; PRK09376 288681013923 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 288681013924 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 288681013925 RNA binding site [nucleotide binding]; other site 288681013926 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 288681013927 multimer interface [polypeptide binding]; other site 288681013928 Walker A motif; other site 288681013929 ATP binding site [chemical binding]; other site 288681013930 Walker B motif; other site 288681013931 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 288681013932 putative active site [active] 288681013933 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 288681013934 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 288681013935 hinge; other site 288681013936 active site 288681013937 hypothetical protein; Provisional; Region: PRK08185 288681013938 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681013939 intersubunit interface [polypeptide binding]; other site 288681013940 active site 288681013941 zinc binding site [ion binding]; other site 288681013942 Na+ binding site [ion binding]; other site 288681013943 Response regulator receiver domain; Region: Response_reg; pfam00072 288681013944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013945 active site 288681013946 phosphorylation site [posttranslational modification] 288681013947 intermolecular recognition site; other site 288681013948 dimerization interface [polypeptide binding]; other site 288681013949 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 288681013950 CTP synthetase; Validated; Region: pyrG; PRK05380 288681013951 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 288681013952 Catalytic site [active] 288681013953 active site 288681013954 UTP binding site [chemical binding]; other site 288681013955 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 288681013956 active site 288681013957 putative oxyanion hole; other site 288681013958 catalytic triad [active] 288681013959 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 288681013960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681013961 Helix-turn-helix domains; Region: HTH; cl00088 288681013962 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681013963 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681013964 FAD binding site [chemical binding]; other site 288681013965 homotetramer interface [polypeptide binding]; other site 288681013966 substrate binding pocket [chemical binding]; other site 288681013967 catalytic base [active] 288681013968 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681013969 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681013970 FAD binding site [chemical binding]; other site 288681013971 homotetramer interface [polypeptide binding]; other site 288681013972 substrate binding pocket [chemical binding]; other site 288681013973 catalytic base [active] 288681013974 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 288681013975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681013976 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681013977 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 288681013978 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681013979 dimer interface [polypeptide binding]; other site 288681013980 active site 288681013981 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 288681013982 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 288681013983 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 288681013984 Cysteine-rich domain; Region: CCG; pfam02754 288681013985 Cysteine-rich domain; Region: CCG; pfam02754 288681013986 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681013987 PLD-like domain; Region: PLDc_2; pfam13091 288681013988 putative active site [active] 288681013989 catalytic site [active] 288681013990 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681013991 PLD-like domain; Region: PLDc_2; pfam13091 288681013992 putative active site [active] 288681013993 catalytic site [active] 288681013994 UV-endonuclease UvdE; Region: UvdE; cl10036 288681013995 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 288681013996 PAS domain S-box; Region: sensory_box; TIGR00229 288681013997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681013998 putative active site [active] 288681013999 heme pocket [chemical binding]; other site 288681014000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681014001 metal binding site [ion binding]; metal-binding site 288681014002 active site 288681014003 I-site; other site 288681014004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681014005 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 288681014006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681014007 non-specific DNA binding site [nucleotide binding]; other site 288681014008 salt bridge; other site 288681014009 sequence-specific DNA binding site [nucleotide binding]; other site 288681014010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681014012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014013 active site 288681014014 phosphorylation site [posttranslational modification] 288681014015 intermolecular recognition site; other site 288681014016 dimerization interface [polypeptide binding]; other site 288681014017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681014018 DNA binding residues [nucleotide binding] 288681014019 dimerization interface [polypeptide binding]; other site 288681014020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681014021 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 288681014022 Histidine kinase; Region: HisKA_3; pfam07730 288681014023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 288681014024 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681014025 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681014026 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 288681014027 Walker A/P-loop; other site 288681014028 ATP binding site [chemical binding]; other site 288681014029 Q-loop/lid; other site 288681014030 ABC transporter signature motif; other site 288681014031 Walker B; other site 288681014032 D-loop; other site 288681014033 H-loop/switch region; other site 288681014034 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681014035 active site 288681014036 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 288681014037 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014038 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014039 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014040 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014041 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014042 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014043 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014044 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014045 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014046 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014047 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014048 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014049 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014050 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014051 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014052 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014053 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014054 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014055 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014056 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014057 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014058 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014059 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014060 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014061 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014062 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 288681014063 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288681014064 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 288681014065 PA/protease or protease-like domain interface [polypeptide binding]; other site 288681014066 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 288681014067 metal binding site [ion binding]; metal-binding site 288681014068 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 288681014069 RNA polymerase sigma factor; Provisional; Region: PRK12522 288681014070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681014071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681014072 DNA binding residues [nucleotide binding] 288681014073 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 288681014074 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 288681014075 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 288681014076 active site 288681014077 HIGH motif; other site 288681014078 KMSK motif region; other site 288681014079 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 288681014080 tRNA binding surface [nucleotide binding]; other site 288681014081 anticodon binding site; other site 288681014082 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 288681014083 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681014084 putative dimer interface [polypeptide binding]; other site 288681014085 catalytic triad [active] 288681014086 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 288681014087 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 288681014088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 288681014089 Arginase family; Region: Arginase; cl00306 288681014090 spermidine synthase; Provisional; Region: PRK00811 288681014091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681014092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681014094 putative substrate translocation pore; other site 288681014095 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681014096 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 288681014097 DNA binding residues [nucleotide binding] 288681014098 putative dimer interface [polypeptide binding]; other site 288681014099 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681014100 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 288681014101 active site 288681014102 catalytic site [active] 288681014103 metal binding site [ion binding]; metal-binding site 288681014104 dimer interface [polypeptide binding]; other site 288681014105 Transglycosylase; Region: Transgly; cl07896 288681014106 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681014107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014108 YwhD family; Region: YwhD; pfam08741 288681014109 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 288681014110 active site 288681014111 putative substrate binding region [chemical binding]; other site 288681014112 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 288681014113 active site 1 [active] 288681014114 dimer interface [polypeptide binding]; other site 288681014115 hexamer interface [polypeptide binding]; other site 288681014116 active site 2 [active] 288681014117 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 288681014118 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681014119 Zn2+ binding site [ion binding]; other site 288681014120 Mg2+ binding site [ion binding]; other site 288681014121 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681014122 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681014123 intersubunit interface [polypeptide binding]; other site 288681014124 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681014125 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681014126 Walker A/P-loop; other site 288681014127 ATP binding site [chemical binding]; other site 288681014128 Q-loop/lid; other site 288681014129 ABC transporter signature motif; other site 288681014130 Walker B; other site 288681014131 D-loop; other site 288681014132 H-loop/switch region; other site 288681014133 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681014134 ABC-ATPase subunit interface; other site 288681014135 dimer interface [polypeptide binding]; other site 288681014136 putative PBP binding regions; other site 288681014137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681014138 ABC-ATPase subunit interface; other site 288681014139 dimer interface [polypeptide binding]; other site 288681014140 putative PBP binding regions; other site 288681014141 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 288681014142 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 288681014143 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681014144 hypothetical protein; Provisional; Region: PRK06760; cl11698 288681014145 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288681014146 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 288681014147 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 288681014148 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 288681014149 Chlorite dismutase; Region: Chlor_dismutase; cl01280 288681014150 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681014151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014152 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 288681014153 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681014154 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 288681014155 Protein of unknown function (DUF423); Region: DUF423; cl01008 288681014156 Ion channel; Region: Ion_trans_2; cl11596 288681014157 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681014158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014159 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 288681014160 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681014161 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681014162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014163 motif II; other site 288681014164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014165 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 288681014166 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 288681014167 ligand binding site [chemical binding]; other site 288681014168 active site 288681014169 UGI interface [polypeptide binding]; other site 288681014170 catalytic site [active] 288681014171 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 288681014172 ABC-2 type transporter; Region: ABC2_membrane; cl11417 288681014173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681014174 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 288681014175 Walker A/P-loop; other site 288681014176 ATP binding site [chemical binding]; other site 288681014177 Q-loop/lid; other site 288681014178 ABC transporter signature motif; other site 288681014179 Walker B; other site 288681014180 D-loop; other site 288681014181 H-loop/switch region; other site 288681014182 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 288681014183 active site 288681014184 catalytic triad [active] 288681014185 oxyanion hole [active] 288681014186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681014187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681014188 DNA binding site [nucleotide binding] 288681014189 domain linker motif; other site 288681014190 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681014191 putative dimerization interface [polypeptide binding]; other site 288681014192 putative ligand binding site [chemical binding]; other site 288681014193 Predicted membrane protein [Function unknown]; Region: COG2364 288681014194 homoserine dehydrogenase; Provisional; Region: PRK06349 288681014195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014196 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681014197 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 288681014198 homoserine O-succinyltransferase; Provisional; Region: PRK05368 288681014199 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 288681014200 proposed active site lysine [active] 288681014201 conserved cys residue [active] 288681014202 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 288681014203 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681014204 homodimer interface [polypeptide binding]; other site 288681014205 substrate-cofactor binding pocket; other site 288681014206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681014207 catalytic residue [active] 288681014208 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 288681014209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014210 active site 288681014211 motif I; other site 288681014212 motif II; other site 288681014213 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 288681014214 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681014215 ligand binding site [chemical binding]; other site 288681014216 flexible hinge region; other site 288681014217 Helix-turn-helix domains; Region: HTH; cl00088 288681014218 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681014219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681014220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014221 active site 288681014222 phosphorylation site [posttranslational modification] 288681014223 intermolecular recognition site; other site 288681014224 dimerization interface [polypeptide binding]; other site 288681014225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681014226 DNA binding residues [nucleotide binding] 288681014227 dimerization interface [polypeptide binding]; other site 288681014228 GAF domain; Region: GAF; cl15785 288681014229 GAF domain; Region: GAF_2; pfam13185 288681014230 GAF domain; Region: GAF; cl15785 288681014231 GAF domain; Region: GAF_2; pfam13185 288681014232 Histidine kinase; Region: HisKA_3; pfam07730 288681014233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 288681014234 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288681014235 dimer interface [polypeptide binding]; other site 288681014236 substrate binding site [chemical binding]; other site 288681014237 ATP binding site [chemical binding]; other site 288681014238 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681014239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681014240 metal binding site [ion binding]; metal-binding site 288681014241 active site 288681014242 I-site; other site 288681014243 Protein of unknown function (DUF466); Region: DUF466; cl01082 288681014244 carbon starvation protein A; Provisional; Region: PRK15015 288681014245 Carbon starvation protein CstA; Region: CstA; pfam02554 288681014246 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 288681014247 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681014248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014249 active site 288681014250 phosphorylation site [posttranslational modification] 288681014251 intermolecular recognition site; other site 288681014252 dimerization interface [polypeptide binding]; other site 288681014253 LytTr DNA-binding domain; Region: LytTR; cl04498 288681014254 benzoate transport; Region: 2A0115; TIGR00895 288681014255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014256 putative substrate translocation pore; other site 288681014257 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 288681014258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 288681014260 Predicted membrane protein [Function unknown]; Region: COG2860 288681014261 UPF0126 domain; Region: UPF0126; pfam03458 288681014262 UPF0126 domain; Region: UPF0126; pfam03458 288681014263 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 288681014264 heme-binding site [chemical binding]; other site 288681014265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681014266 dimer interface [polypeptide binding]; other site 288681014267 putative CheW interface [polypeptide binding]; other site 288681014268 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 288681014269 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 288681014270 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681014271 MatE; Region: MatE; cl10513 288681014272 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 288681014273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 288681014274 active site 288681014275 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681014276 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681014277 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681014278 ABC transporter; Region: ABC_tran_2; pfam12848 288681014279 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 288681014280 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 288681014281 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 288681014282 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 288681014283 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 288681014284 Ligand binding site; other site 288681014285 Putative Catalytic site; other site 288681014286 DXD motif; other site 288681014287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014288 Helix-turn-helix domains; Region: HTH; cl00088 288681014289 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 288681014290 Protein export membrane protein; Region: SecD_SecF; cl14618 288681014291 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 288681014292 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 288681014293 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 288681014294 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681014295 LrgB-like family; Region: LrgB; cl00596 288681014296 LrgA family; Region: LrgA; cl00608 288681014297 two-component response regulator; Provisional; Region: PRK14084 288681014298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014299 active site 288681014300 phosphorylation site [posttranslational modification] 288681014301 intermolecular recognition site; other site 288681014302 dimerization interface [polypeptide binding]; other site 288681014303 LytTr DNA-binding domain; Region: LytTR; cl04498 288681014304 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 288681014305 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 288681014306 GAF domain; Region: GAF; cl15785 288681014307 Histidine kinase; Region: His_kinase; pfam06580 288681014308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681014309 ATP binding site [chemical binding]; other site 288681014310 Mg2+ binding site [ion binding]; other site 288681014311 G-X-G motif; other site 288681014312 benzoate transport; Region: 2A0115; TIGR00895 288681014313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014314 putative substrate translocation pore; other site 288681014315 BCCT family transporter; Region: BCCT; cl00569 288681014316 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 288681014317 active site 288681014318 dimer interface [polypeptide binding]; other site 288681014319 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681014320 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681014321 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681014322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681014323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014324 NAD(P) binding site [chemical binding]; other site 288681014325 active site 288681014326 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 288681014327 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 288681014328 UDP-glucose 4-epimerase; Region: PLN02240 288681014329 NAD binding site [chemical binding]; other site 288681014330 homodimer interface [polypeptide binding]; other site 288681014331 active site 288681014332 substrate binding site [chemical binding]; other site 288681014333 Haemolysin-III related; Region: HlyIII; cl03831 288681014334 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 288681014335 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 288681014336 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681014337 ATP binding site [chemical binding]; other site 288681014338 Mg++ binding site [ion binding]; other site 288681014339 motif III; other site 288681014340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681014341 nucleotide binding region [chemical binding]; other site 288681014342 ATP-binding site [chemical binding]; other site 288681014343 DbpA RNA binding domain; Region: DbpA; pfam03880 288681014344 OpgC protein; Region: OpgC_C; cl00792 288681014345 Acyltransferase family; Region: Acyl_transf_3; pfam01757 288681014346 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 288681014347 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 288681014348 active site 288681014349 oligoendopeptidase F; Region: pepF; TIGR00181 288681014350 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 288681014351 active site 288681014352 Zn binding site [ion binding]; other site 288681014353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681014354 FeS/SAM binding site; other site 288681014355 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 288681014356 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 288681014357 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 288681014358 YyzF-like protein; Region: YyzF; cl15733 288681014359 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 288681014360 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 288681014361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681014362 protein binding site [polypeptide binding]; other site 288681014363 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681014364 YycH protein; Region: YycI; cl02015 288681014365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 288681014366 YycH protein; Region: YycH; pfam07435 288681014367 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 288681014368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 288681014369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681014370 dimerization interface [polypeptide binding]; other site 288681014371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681014372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681014373 dimer interface [polypeptide binding]; other site 288681014374 phosphorylation site [posttranslational modification] 288681014375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681014376 ATP binding site [chemical binding]; other site 288681014377 Mg2+ binding site [ion binding]; other site 288681014378 G-X-G motif; other site 288681014379 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681014380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014381 active site 288681014382 phosphorylation site [posttranslational modification] 288681014383 intermolecular recognition site; other site 288681014384 dimerization interface [polypeptide binding]; other site 288681014385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681014386 DNA binding site [nucleotide binding] 288681014387 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 288681014388 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 288681014389 GDP-binding site [chemical binding]; other site 288681014390 ACT binding site; other site 288681014391 IMP binding site; other site 288681014392 replicative DNA helicase; Provisional; Region: PRK05748 288681014393 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 288681014394 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 288681014395 Walker A motif; other site 288681014396 ATP binding site [chemical binding]; other site 288681014397 Walker B motif; other site 288681014398 DNA binding loops [nucleotide binding] 288681014399 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 288681014400 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 288681014401 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 288681014402 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 288681014403 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 288681014404 DHH family; Region: DHH; pfam01368 288681014405 DHHA1 domain; Region: DHHA1; pfam02272 288681014406 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 288681014407 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 288681014408 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 288681014409 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288681014410 dimer interface [polypeptide binding]; other site 288681014411 ssDNA binding site [nucleotide binding]; other site 288681014412 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681014413 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 288681014414 GTP-binding protein YchF; Reviewed; Region: PRK09601 288681014415 YchF GTPase; Region: YchF; cd01900 288681014416 G1 box; other site 288681014417 GTP/Mg2+ binding site [chemical binding]; other site 288681014418 Switch I region; other site 288681014419 G2 box; other site 288681014420 Switch II region; other site 288681014421 G3 box; other site 288681014422 G4 box; other site 288681014423 G5 box; other site 288681014424 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 288681014425 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 288681014426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 288681014427 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 288681014428 ParB-like partition proteins; Region: parB_part; TIGR00180 288681014429 ParB-like nuclease domain; Region: ParBc; cl02129 288681014430 KorB domain; Region: KorB; pfam08535 288681014431 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288681014432 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681014433 P-loop; other site 288681014434 Magnesium ion binding site [ion binding]; other site 288681014435 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681014436 Magnesium ion binding site [ion binding]; other site 288681014437 ParB-like partition proteins; Region: parB_part; TIGR00180 288681014438 ParB-like nuclease domain; Region: ParBc; cl02129 288681014439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 288681014440 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 288681014441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014442 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 288681014443 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 288681014444 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 288681014445 trmE is a tRNA modification GTPase; Region: trmE; cd04164 288681014446 G1 box; other site 288681014447 GTP/Mg2+ binding site [chemical binding]; other site 288681014448 Switch I region; other site 288681014449 G2 box; other site 288681014450 Switch II region; other site 288681014451 G3 box; other site 288681014452 G4 box; other site 288681014453 G5 box; other site 288681014454 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 288681014455 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 288681014456 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 288681014457 G-X-X-G motif; other site 288681014458 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 288681014459 RxxxH motif; other site 288681014460 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 288681014461 Ribonuclease P; Region: Ribonuclease_P; cl00457 288681014462 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 288681014463 exosporium leader peptide; Region: exospor_lead; TIGR03720 288681014464 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 288681014465 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681014466 DNA-binding interface [nucleotide binding]; DNA binding site 288681014467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681014468 Gram positive anchor; Region: Gram_pos_anchor; cl15427 288681014469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 288681014470 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681014471 active site 288681014472 catalytic site [active] 288681014473 substrate binding site [chemical binding]; other site 288681014474 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681014475 Cache domain; Region: Cache_1; pfam02743 288681014476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681014477 dimerization interface [polypeptide binding]; other site 288681014478 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681014479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681014480 dimer interface [polypeptide binding]; other site 288681014481 putative CheW interface [polypeptide binding]; other site 288681014482 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 288681014483 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 288681014484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681014485 active site 288681014486 DNA binding site [nucleotide binding] 288681014487 Int/Topo IB signature motif; other site 288681014488 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 288681014489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681014490 catalytic residues [active] 288681014491 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 288681014492 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 288681014493 putative active site [active] 288681014494 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 288681014495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681014496 Walker A/P-loop; other site 288681014497 ATP binding site [chemical binding]; other site 288681014498 Q-loop/lid; other site 288681014499 ABC transporter signature motif; other site 288681014500 Walker B; other site 288681014501 D-loop; other site 288681014502 H-loop/switch region; other site 288681014503 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681014504 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681014505 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681014506 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681014507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681014508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681014509 dimer interface [polypeptide binding]; other site 288681014510 conserved gate region; other site 288681014511 ABC-ATPase subunit interface; other site 288681014512 MatE; Region: MatE; cl10513 288681014513 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681014514 glucose-1-phosphate adenylyltransferase; Region: PLN02241 288681014515 similar to transposase 288681014516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681014517 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 288681014518 active site 288681014519 DNA binding site [nucleotide binding] 288681014520 Int/Topo IB signature motif; other site 288681014521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014523 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014524 Probable transposase; Region: OrfB_IS605; pfam01385 288681014525 nonfunctional sodium/proline symporter family protein 288681014526 BCCT family transporter; Region: BCCT; cl00569 288681014527 Integrase core domain; Region: rve; cl01316 288681014528 Integrase core domain; Region: rve_3; cl15866 288681014529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014530 Helix-turn-helix domains; Region: HTH; cl00088 288681014531 Phospholipid methyltransferase; Region: PEMT; cl00763 288681014532 similar to transposase 288681014533 Probable transposase; Region: OrfB_IS605; pfam01385 288681014534 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014535 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 288681014536 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681014537 active site 288681014538 DNA binding site [nucleotide binding] 288681014539 Int/Topo IB signature motif; other site 288681014540 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681014541 DNA binding residues [nucleotide binding] 288681014542 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 288681014543 DNA binding residues [nucleotide binding] 288681014544 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681014545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 288681014550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681014551 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 288681014552 Walker A/P-loop; other site 288681014553 ATP binding site [chemical binding]; other site 288681014554 Q-loop/lid; other site 288681014555 ABC transporter signature motif; other site 288681014556 Walker B; other site 288681014557 D-loop; other site 288681014558 H-loop/switch region; other site 288681014559 FtsX-like permease family; Region: FtsX; cl15850 288681014560 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 288681014561 FtsX-like permease family; Region: FtsX; cl15850 288681014562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681014564 putative substrate translocation pore; other site 288681014565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014566 Helix-turn-helix domains; Region: HTH; cl00088 288681014567 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681014568 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681014569 catalytic residues [active] 288681014570 catalytic nucleophile [active] 288681014571 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681014572 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681014573 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681014574 Synaptic Site I dimer interface [polypeptide binding]; other site 288681014575 DNA binding site [nucleotide binding] 288681014576 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681014577 DNA-binding interface [nucleotide binding]; DNA binding site 288681014578 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681014579 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681014580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014581 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 288681014582 Helix-turn-helix domains; Region: HTH; cl00088 288681014583 Helix-turn-helix domains; Region: HTH; cl00088 288681014584 Integrase core domain; Region: rve; cl01316 288681014585 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 288681014586 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681014587 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681014588 catalytic residues [active] 288681014589 catalytic nucleophile [active] 288681014590 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681014591 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681014592 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681014593 Synaptic Site I dimer interface [polypeptide binding]; other site 288681014594 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681014595 DNA-binding interface [nucleotide binding]; DNA binding site 288681014596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014597 Helix-turn-helix domains; Region: HTH; cl00088 288681014598 hypothetical protein; Provisional; Region: PRK06185 288681014599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014602 S-layer homology domain; Region: SLH; pfam00395 288681014603 S-layer homology domain; Region: SLH; pfam00395 288681014604 S-layer homology domain; Region: SLH; pfam00395 288681014605 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 288681014606 Bacterial SH3 domain; Region: SH3_3; cl02551 288681014607 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 288681014608 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 288681014609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014610 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 288681014611 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 288681014612 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 288681014613 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 288681014614 EamA-like transporter family; Region: EamA; cl01037 288681014615 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681014616 EamA-like transporter family; Region: EamA; cl01037 288681014617 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681014618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681014619 DNA-binding site [nucleotide binding]; DNA binding site 288681014620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681014621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681014622 homodimer interface [polypeptide binding]; other site 288681014623 catalytic residue [active] 288681014624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014625 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014626 Probable transposase; Region: OrfB_IS605; pfam01385 288681014627 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014628 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 288681014629 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681014630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014631 putative substrate translocation pore; other site 288681014632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 288681014633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681014634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 288681014636 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681014637 active site 288681014638 Zn binding site [ion binding]; other site 288681014639 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 288681014640 positive control sigma-like factor; Validated; Region: PRK06930 288681014641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681014642 DNA binding residues [nucleotide binding] 288681014643 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 288681014644 Recombination protein U; Region: RecU; cl01314 288681014645 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681014647 dimerization interface [polypeptide binding]; other site 288681014648 putative DNA binding site [nucleotide binding]; other site 288681014649 putative Zn2+ binding site [ion binding]; other site 288681014650 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681014651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014652 putative substrate translocation pore; other site 288681014653 nonfunctional IS231-related transposase 288681014654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681014655 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 288681014656 Sm1 motif; other site 288681014657 D1 - D2 interaction site; other site 288681014658 D3 - B interaction site; other site 288681014659 Hfq - Hfq interaction site; other site 288681014660 RNA binding pocket [nucleotide binding]; other site 288681014661 Sm2 motif; other site 288681014662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681014663 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681014664 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 288681014665 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681014666 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681014667 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 288681014668 putative active site [active] 288681014669 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681014670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014671 Probable transposase; Region: OrfB_IS605; pfam01385 288681014672 transposase fragments 288681014673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014674 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 288681014675 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 288681014676 Spore germination protein; Region: Spore_permease; cl15802 288681014677 Spore germination protein; Region: Spore_permease; cl15802 288681014678 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 288681014679 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681014680 Viral enhancin protein; Region: Enhancin; pfam03272 288681014681 Peptidase M60-like family; Region: M60-like; pfam13402 288681014682 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681014683 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 288681014684 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681014685 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 288681014686 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681014687 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681014688 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681014689 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681014690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681014691 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 288681014692 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681014693 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681014694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681014695 dimerization interface [polypeptide binding]; other site 288681014696 putative DNA binding site [nucleotide binding]; other site 288681014697 putative Zn2+ binding site [ion binding]; other site 288681014698 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 288681014699 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681014700 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681014701 catalytic motif [active] 288681014702 Zn binding site [ion binding]; other site 288681014703 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 288681014704 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681014705 dimerization interface [polypeptide binding]; other site 288681014706 active site 288681014707 Helix-turn-helix domains; Region: HTH; cl00088 288681014708 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681014709 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681014710 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 288681014711 active site 288681014712 catalytic site [active] 288681014713 Excalibur calcium-binding domain; Region: Excalibur; cl05460 288681014714 Gram positive anchor; Region: Gram_pos_anchor; cl15427 288681014715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681014716 non-specific DNA binding site [nucleotide binding]; other site 288681014717 salt bridge; other site 288681014718 sequence-specific DNA binding site [nucleotide binding]; other site 288681014719 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681014720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681014721 active site 288681014722 DNA binding site [nucleotide binding] 288681014723 Int/Topo IB signature motif; other site 288681014724 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 288681014725 nonfunctional IS231-related transposases 288681014726 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681014727 DltD N-terminal region; Region: DltD_N; pfam04915 288681014728 DltD central region; Region: DltD_M; pfam04918 288681014729 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288681014730 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 288681014731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681014732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014733 active site 288681014734 phosphorylation site [posttranslational modification] 288681014735 intermolecular recognition site; other site 288681014736 dimerization interface [polypeptide binding]; other site 288681014737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681014738 DNA binding site [nucleotide binding] 288681014739 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 288681014740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681014741 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681014742 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681014743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014744 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014745 Probable transposase; Region: OrfB_IS605; pfam01385 288681014746 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014747 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681014748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014749 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014750 Probable transposase; Region: OrfB_IS605; pfam01385 288681014751 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014752 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681014753 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 288681014754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288681014755 HTH-like domain; Region: HTH_21; pfam13276 288681014756 Integrase core domain; Region: rve; cl01316 288681014757 Integrase core domain; Region: rve_3; cl15866 288681014758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681014759 Helix-turn-helix domains; Region: HTH; cl00088 288681014760 Helix-turn-helix domains; Region: HTH; cl00088 288681014761 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 288681014762 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 288681014763 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 288681014764 putative active site [active] 288681014765 putative NTP binding site [chemical binding]; other site 288681014766 putative nucleic acid binding site [nucleotide binding]; other site 288681014767 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 288681014768 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 288681014769 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681014770 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681014771 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 288681014772 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681014773 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681014774 Catalytic site [active] 288681014775 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 288681014776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681014777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681014778 DNA binding residues [nucleotide binding] 288681014779 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681014780 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681014781 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 288681014782 nucleotide binding site [chemical binding]; other site 288681014783 Fibronectin type III protein; Region: DUF3672; pfam12421 288681014784 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 288681014785 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 288681014786 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 288681014787 Helix-turn-helix domains; Region: HTH; cl00088 288681014788 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 288681014789 TcpE family; Region: TcpE; pfam12648 288681014790 AAA-like domain; Region: AAA_10; pfam12846 288681014791 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 288681014792 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 288681014793 large tegument protein UL36; Provisional; Region: PHA03247 288681014794 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 288681014795 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288681014796 catalytic residue [active] 288681014797 NlpC/P60 family; Region: NLPC_P60; cl11438 288681014798 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 288681014799 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 288681014800 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 288681014801 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681014802 RNA binding site [nucleotide binding]; other site 288681014803 hypothetical protein; Provisional; Region: PRK08582 288681014804 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681014805 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 288681014806 MPN+ (JAMM) motif; other site 288681014807 Zinc-binding site [ion binding]; other site 288681014808 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681014809 putative dimer interface [polypeptide binding]; other site 288681014810 catalytic triad [active] 288681014811 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681014812 Transposase; Region: DEDD_Tnp_IS110; pfam01548 288681014813 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 288681014814 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681014815 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288681014816 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 288681014817 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 288681014818 nudix motif; other site 288681014819 Predicted permeases [General function prediction only]; Region: RarD; COG2962 288681014820 EamA-like transporter family; Region: EamA; cl01037 288681014821 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 288681014822 dimer interface [polypeptide binding]; other site 288681014823 putative tRNA-binding site [nucleotide binding]; other site 288681014824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014825 motif II; other site 288681014826 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 288681014827 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681014828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681014830 nonfunctional dihydropyrimidine dehydrogenase (NADPH+) 288681014831 nonfunctional dihydroorotate dehydrogenase 288681014832 Protein of unknown function, DUF606; Region: DUF606; cl01273 288681014833 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681014834 active site 288681014835 NTP binding site [chemical binding]; other site 288681014836 metal binding triad [ion binding]; metal-binding site 288681014837 antibiotic binding site [chemical binding]; other site 288681014838 Protein of unknown function DUF86; Region: DUF86; cl01031 288681014839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014840 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014841 Probable transposase; Region: OrfB_IS605; pfam01385 288681014842 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014843 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681014844 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681014845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 288681014846 Chitin binding domain; Region: Chitin_bind_3; cl03871 288681014847 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681014848 Interdomain contacts; other site 288681014849 Cytokine receptor motif; other site 288681014850 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681014851 Interdomain contacts; other site 288681014852 Cytokine receptor motif; other site 288681014853 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 288681014854 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 288681014855 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 288681014856 catalytic residues [active] 288681014857 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288681014858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 288681014859 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288681014860 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288681014861 Helix-turn-helix domains; Region: HTH; cl00088 288681014862 putative transposase OrfB; Reviewed; Region: PHA02517 288681014863 HTH-like domain; Region: HTH_21; pfam13276 288681014864 Integrase core domain; Region: rve; cl01316 288681014865 Integrase core domain; Region: rve_3; cl15866 288681014866 transposase, C-terminal fragment 288681014867 transposase, N-terminal fragment 288681014868 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681014869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014870 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681014871 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 288681014872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014873 putative substrate translocation pore; other site 288681014874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681014876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681014877 DNA binding site [nucleotide binding] 288681014878 domain linker motif; other site 288681014879 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681014880 dimerization interface [polypeptide binding]; other site 288681014881 ligand binding site [chemical binding]; other site 288681014882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681014883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681014884 DNA binding site [nucleotide binding] 288681014885 domain linker motif; other site 288681014886 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681014887 dimerization interface [polypeptide binding]; other site 288681014888 ligand binding site [chemical binding]; other site 288681014889 polyol permease family; Region: 2A0118; TIGR00897 288681014890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014891 putative substrate translocation pore; other site 288681014892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681014893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681014894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 288681014895 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681014896 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681014897 substrate binding site [chemical binding]; other site 288681014898 ATP binding site [chemical binding]; other site 288681014899 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681014900 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681014901 tetrameric interface [polypeptide binding]; other site 288681014902 NAD binding site [chemical binding]; other site 288681014903 catalytic residues [active] 288681014904 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 288681014905 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681014906 PYR/PP interface [polypeptide binding]; other site 288681014907 dimer interface [polypeptide binding]; other site 288681014908 TPP binding site [chemical binding]; other site 288681014909 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 288681014910 Ph1570 protein; Region: Ph1570; pfam09638 288681014911 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 288681014912 TPP-binding site; other site 288681014913 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681014914 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 288681014915 Metal-binding active site; metal-binding site 288681014916 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681014917 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681014918 DNA binding site [nucleotide binding] 288681014919 domain linker motif; other site 288681014920 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681014921 dimerization interface [polypeptide binding]; other site 288681014922 ligand binding site [chemical binding]; other site 288681014923 hypothetical protein; Provisional; Region: PRK08185 288681014924 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681014925 intersubunit interface [polypeptide binding]; other site 288681014926 active site 288681014927 zinc binding site [ion binding]; other site 288681014928 Na+ binding site [ion binding]; other site 288681014929 KduI/IolB family; Region: KduI; cl01508 288681014930 putative transposase OrfB; Reviewed; Region: PHA02517 288681014931 HTH-like domain; Region: HTH_21; pfam13276 288681014932 Integrase core domain; Region: rve; cl01316 288681014933 Integrase core domain; Region: rve_3; cl15866 288681014934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681014935 Helix-turn-helix domains; Region: HTH; cl00088 288681014936 Helix-turn-helix domains; Region: HTH; cl00088 288681014937 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 288681014938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681014939 Walker A motif; other site 288681014940 ATP binding site [chemical binding]; other site 288681014941 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 288681014942 aminotransferase A; Validated; Region: PRK07683 288681014943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681014944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681014945 homodimer interface [polypeptide binding]; other site 288681014946 catalytic residue [active] 288681014947 nonfuctional DNA topoisomerase III 288681014948 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681014949 metal ion-dependent adhesion site (MIDAS); other site 288681014950 nonfunctional transposase 288681014951 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681014952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681014953 Walker A motif; other site 288681014954 ATP binding site [chemical binding]; other site 288681014955 Walker B motif; other site 288681014956 arginine finger; other site 288681014957 putative transposase OrfB; Reviewed; Region: PHA02517 288681014958 HTH-like domain; Region: HTH_21; pfam13276 288681014959 Integrase core domain; Region: rve; cl01316 288681014960 Integrase core domain; Region: rve_3; cl15866 288681014961 YolD-like protein; Region: YolD; pfam08863 288681014962 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681014963 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681014964 DNA binding residues [nucleotide binding] 288681014965 drug binding residues [chemical binding]; other site 288681014966 dimer interface [polypeptide binding]; other site 288681014967 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681014968 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 288681014969 active site 288681014970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681014971 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681014972 Probable transposase; Region: OrfB_IS605; pfam01385 288681014973 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681014974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681014976 TPR motif; other site 288681014977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014978 binding surface 288681014979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681014981 TPR motif; other site 288681014982 binding surface 288681014983 nonfunctional conserved hypothetical protein 288681014984 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 288681014985 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681014986 Helix-turn-helix domains; Region: HTH; cl00088 288681014987 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681014988 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 288681014989 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 288681014990 active site 288681014991 intersubunit interface [polypeptide binding]; other site 288681014992 catalytic residue [active] 288681014993 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681014994 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681014995 substrate binding site [chemical binding]; other site 288681014996 ATP binding site [chemical binding]; other site 288681014997 KduI/IolB family; Region: KduI; cl01508 288681014998 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 288681014999 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 288681015000 NADP binding site [chemical binding]; other site 288681015001 homodimer interface [polypeptide binding]; other site 288681015002 active site 288681015003 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 288681015004 active pocket/dimerization site; other site 288681015005 active site 288681015006 phosphorylation site [posttranslational modification] 288681015007 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 288681015008 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 288681015009 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 288681015010 active site 288681015011 phosphorylation site [posttranslational modification] 288681015012 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 288681015013 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 288681015014 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 288681015015 substrate binding site [chemical binding]; other site 288681015016 catalytic residues [active] 288681015017 Cupin domain; Region: Cupin_2; cl09118 288681015018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681015019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681015020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681015021 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 288681015022 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 288681015023 active site 288681015024 catalytic residues [active] 288681015025 galactokinase; Provisional; Region: PRK05322 288681015026 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 288681015027 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681015028 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681015029 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 288681015030 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681015031 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681015032 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681015033 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681015034 putative NAD(P) binding site [chemical binding]; other site 288681015035 catalytic Zn binding site [ion binding]; other site 288681015036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015037 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015038 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681015039 Helix-turn-helix domains; Region: HTH; cl00088 288681015040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681015041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015042 putative substrate translocation pore; other site 288681015043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681015044 Helix-turn-helix domains; Region: HTH; cl00088 288681015045 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681015046 Zn binding site [ion binding]; other site 288681015047 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681015048 Zn binding site [ion binding]; other site 288681015049 Flavin Reductases; Region: FlaRed; cl00801 288681015050 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681015051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681015052 Zn binding site [ion binding]; other site 288681015053 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681015054 Zn binding site [ion binding]; other site 288681015055 Predicted esterase [General function prediction only]; Region: COG0400 288681015056 Sugar transport protein; Region: Sugar_transport; pfam06800 288681015057 glucose-1-dehydrogenase; Provisional; Region: PRK08936 288681015058 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 288681015059 NAD binding site [chemical binding]; other site 288681015060 homodimer interface [polypeptide binding]; other site 288681015061 active site 288681015062 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681015063 dimer interface [polypeptide binding]; other site 288681015064 FMN binding site [chemical binding]; other site 288681015065 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 288681015066 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681015067 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 288681015068 putative active site [active] 288681015069 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681015070 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681015071 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 288681015072 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681015073 active site 288681015074 Zn binding site [ion binding]; other site 288681015075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681015076 PAS domain; Region: PAS_9; pfam13426 288681015077 putative active site [active] 288681015078 heme pocket [chemical binding]; other site 288681015079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681015080 dimer interface [polypeptide binding]; other site 288681015081 putative CheW interface [polypeptide binding]; other site 288681015082 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681015083 Integrase core domain; Region: rve; cl01316 288681015084 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681015085 two component system sensor kinase SsrA; Provisional; Region: PRK15347 288681015086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681015087 dimerization interface [polypeptide binding]; other site 288681015088 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681015089 dimer interface [polypeptide binding]; other site 288681015090 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 288681015091 putative CheW interface [polypeptide binding]; other site 288681015092 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681015093 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681015094 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681015095 active site 288681015096 Zn binding site [ion binding]; other site 288681015097 similar to viral enhancin fragment 288681015098 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 288681015099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681015100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681015101 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681015102 active site 288681015103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681015104 S-adenosylmethionine binding site [chemical binding]; other site 288681015105 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015106 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 288681015107 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681015108 putative active site [active] 288681015109 putative metal binding site [ion binding]; other site 288681015110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015111 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015112 Probable transposase; Region: OrfB_IS605; pfam01385 288681015113 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015114 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 288681015115 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 288681015116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681015117 tol-pal system protein YbgF; Provisional; Region: PRK10803 288681015118 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681015119 active site 288681015120 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681015121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015122 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015123 Probable transposase; Region: OrfB_IS605; pfam01385 288681015124 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015125 CHRD domain; Region: CHRD; cl06473 288681015126 Probable transposase; Region: OrfB_IS605; pfam01385 288681015127 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015128 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681015129 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015130 SpoVA protein; Region: SpoVA; cl04298 288681015131 Protein of unknown function (DUF421); Region: DUF421; cl00990 288681015132 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015134 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 288681015135 Int/Topo IB signature motif; other site 288681015136 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681015137 putative FMN binding site [chemical binding]; other site 288681015138 NADPH bind site [chemical binding]; other site 288681015139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015140 putative substrate translocation pore; other site 288681015141 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288681015142 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 288681015143 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 288681015144 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681015145 dimer interface [polypeptide binding]; other site 288681015146 active site 288681015147 CoA binding pocket [chemical binding]; other site 288681015148 similar to IS231 transposase 288681015149 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681015150 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 288681015151 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681015152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015153 non-specific DNA binding site [nucleotide binding]; other site 288681015154 salt bridge; other site 288681015155 sequence-specific DNA binding site [nucleotide binding]; other site 288681015156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015158 non-specific DNA binding site [nucleotide binding]; other site 288681015159 salt bridge; other site 288681015160 sequence-specific DNA binding site [nucleotide binding]; other site 288681015161 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 288681015162 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015163 nonfunctional IS231 transposase 288681015164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015165 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681015166 Ligand binding site; other site 288681015167 Putative Catalytic site; other site 288681015168 DXD motif; other site 288681015169 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681015170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681015171 active site 288681015172 Probable transposase; Region: OrfB_IS605; pfam01385 288681015173 Probable transposase; Region: OrfB_IS605; pfam01385 288681015174 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681015176 dimerization interface [polypeptide binding]; other site 288681015177 putative DNA binding site [nucleotide binding]; other site 288681015178 putative Zn2+ binding site [ion binding]; other site 288681015179 putative transporter; Provisional; Region: PRK11660 288681015180 Sulfate transporter family; Region: Sulfate_transp; cl15842 288681015181 Sulfate transporter family; Region: Sulfate_transp; cl15842 288681015182 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681015183 Phosphopantetheine attachment site; Region: PP-binding; cl09936 288681015184 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 288681015185 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 288681015186 PhnA protein; Region: PhnA; pfam03831 288681015187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015188 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015189 Probable transposase; Region: OrfB_IS605; pfam01385 288681015190 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015191 Recombination protein U; Region: RecU; cl01314 288681015192 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 288681015193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015194 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 288681015195 nonfunctional IS231 transposase 288681015196 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 288681015197 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681015198 homodimer interface [polypeptide binding]; other site 288681015199 dUTPase; Region: dUTPase_2; pfam08761 288681015200 metal binding site [ion binding]; metal-binding site 288681015201 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 288681015202 YopX protein; Region: YopX; cl09859 288681015203 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 288681015204 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 288681015205 putative active site [active] 288681015206 putative NTP binding site [chemical binding]; other site 288681015207 putative nucleic acid binding site [nucleotide binding]; other site 288681015208 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 288681015209 active site 288681015210 Protein of unknown function (DUF998); Region: DUF998; pfam06197 288681015211 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681015212 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 288681015213 Helix-turn-helix domains; Region: HTH; cl00088 288681015214 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288681015215 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015216 P-loop; other site 288681015217 Magnesium ion binding site [ion binding]; other site 288681015218 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015219 Magnesium ion binding site [ion binding]; other site 288681015220 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015221 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681015222 DNA binding residues [nucleotide binding] 288681015223 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 288681015224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 288681015225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015226 non-specific DNA binding site [nucleotide binding]; other site 288681015227 salt bridge; other site 288681015228 sequence-specific DNA binding site [nucleotide binding]; other site 288681015229 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681015230 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 288681015231 CAAX protease self-immunity; Region: Abi; cl00558 288681015232 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681015233 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 288681015234 Int/Topo IB signature motif; other site 288681015235 SEC-C motif; Region: SEC-C; pfam02810 288681015236 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681015238 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681015239 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681015240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015241 non-specific DNA binding site [nucleotide binding]; other site 288681015242 salt bridge; other site 288681015243 sequence-specific DNA binding site [nucleotide binding]; other site 288681015244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015246 Helix-turn-helix domains; Region: HTH; cl00088 288681015247 putative transposase OrfB; Reviewed; Region: PHA02517 288681015248 HTH-like domain; Region: HTH_21; pfam13276 288681015249 Integrase core domain; Region: rve; cl01316 288681015250 Integrase core domain; Region: rve_3; cl15866 288681015251 nonfunctional ImpB/MucB/SamB family protein, N-terminal 288681015252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 288681015254 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 288681015255 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 288681015256 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681015257 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 288681015258 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 288681015259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681015260 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 288681015261 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681015262 Membrane transport protein; Region: Mem_trans; cl09117 288681015263 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 288681015264 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 288681015265 metal binding site [ion binding]; metal-binding site 288681015266 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681015267 ABC-ATPase subunit interface; other site 288681015268 dimer interface [polypeptide binding]; other site 288681015269 putative PBP binding regions; other site 288681015270 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288681015271 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 288681015272 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681015273 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681015274 catalytic residues [active] 288681015275 catalytic nucleophile [active] 288681015276 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681015277 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681015278 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681015279 Synaptic Site I dimer interface [polypeptide binding]; other site 288681015280 DNA binding site [nucleotide binding] 288681015281 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681015282 DNA-binding interface [nucleotide binding]; DNA binding site 288681015283 nonfunctional transposase 288681015284 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681015285 active site 288681015286 catalytic residues [active] 288681015287 DNA binding site [nucleotide binding] 288681015288 Int/Topo IB signature motif; other site 288681015289 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015290 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015292 active site 288681015293 DNA binding site [nucleotide binding] 288681015294 Int/Topo IB signature motif; other site 288681015295 nonfunctional impB/mucB/samB family protein, C-terminal 288681015296 YolD-like protein; Region: YolD; pfam08863 288681015297 Abi-like protein; Region: Abi_2; cl01988 288681015298 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681015299 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681015300 catalytic residues [active] 288681015301 catalytic nucleophile [active] 288681015302 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681015303 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681015304 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681015305 Synaptic Site I dimer interface [polypeptide binding]; other site 288681015306 DNA binding site [nucleotide binding] 288681015307 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 288681015308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681015309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015310 non-specific DNA binding site [nucleotide binding]; other site 288681015311 salt bridge; other site 288681015312 sequence-specific DNA binding site [nucleotide binding]; other site 288681015313 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681015314 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681015315 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 288681015316 Helix-turn-helix domains; Region: HTH; cl00088 288681015317 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 288681015318 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681015319 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681015320 putative active site [active] 288681015321 nucleotide binding site [chemical binding]; other site 288681015322 nudix motif; other site 288681015323 putative metal binding site [ion binding]; other site 288681015324 Haemolysin XhlA; Region: XhlA; pfam10779 288681015325 CAAX protease self-immunity; Region: Abi; cl00558 288681015326 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681015327 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 288681015328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015329 non-specific DNA binding site [nucleotide binding]; other site 288681015330 salt bridge; other site 288681015331 sequence-specific DNA binding site [nucleotide binding]; other site 288681015332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015333 non-specific DNA binding site [nucleotide binding]; other site 288681015334 salt bridge; other site 288681015335 sequence-specific DNA binding site [nucleotide binding]; other site 288681015336 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015337 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681015338 DNA binding residues [nucleotide binding] 288681015339 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681015340 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015341 active site 288681015342 DNA binding site [nucleotide binding] 288681015343 Int/Topo IB signature motif; other site