-- dump date 20120504_134149 -- class Genbank::misc_feature -- table misc_feature_note -- id note 279010000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 279010000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 279010000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000004 Walker A motif; other site 279010000005 ATP binding site [chemical binding]; other site 279010000006 Walker B motif; other site 279010000007 arginine finger; other site 279010000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 279010000009 DnaA box-binding interface [nucleotide binding]; other site 279010000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 279010000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 279010000012 putative DNA binding surface [nucleotide binding]; other site 279010000013 dimer interface [polypeptide binding]; other site 279010000014 beta-clamp/clamp loader binding surface; other site 279010000015 beta-clamp/translesion DNA polymerase binding surface; other site 279010000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 279010000017 recombination protein F; Reviewed; Region: recF; PRK00064 279010000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 279010000019 Walker A/P-loop; other site 279010000020 ATP binding site [chemical binding]; other site 279010000021 Q-loop/lid; other site 279010000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010000023 Q-loop/lid; other site 279010000024 ABC transporter signature motif; other site 279010000025 Walker B; other site 279010000026 D-loop; other site 279010000027 H-loop/switch region; other site 279010000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 279010000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000030 ATP binding site [chemical binding]; other site 279010000031 Mg2+ binding site [ion binding]; other site 279010000032 G-X-G motif; other site 279010000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279010000034 anchoring element; other site 279010000035 dimer interface [polypeptide binding]; other site 279010000036 ATP binding site [chemical binding]; other site 279010000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279010000038 active site 279010000039 putative metal-binding site [ion binding]; other site 279010000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279010000041 DNA gyrase subunit A; Validated; Region: PRK05560 279010000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 279010000043 CAP-like domain; other site 279010000044 active site 279010000045 primary dimer interface [polypeptide binding]; other site 279010000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010000052 YaaC-like Protein; Region: YaaC; pfam14175 279010000053 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 279010000054 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 279010000055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 279010000056 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 279010000057 active site 279010000058 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010000059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000060 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 279010000061 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 279010000062 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 279010000063 active site 279010000064 multimer interface [polypeptide binding]; other site 279010000065 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 279010000066 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 279010000067 predicted active site [active] 279010000068 catalytic triad [active] 279010000069 seryl-tRNA synthetase; Provisional; Region: PRK05431 279010000070 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 279010000071 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 279010000072 dimer interface [polypeptide binding]; other site 279010000073 active site 279010000074 motif 1; other site 279010000075 motif 2; other site 279010000076 motif 3; other site 279010000077 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 279010000078 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 279010000079 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 279010000080 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 279010000081 Helix-turn-helix domains; Region: HTH; cl00088 279010000082 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 279010000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279010000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279010000085 Substrate-binding site [chemical binding]; other site 279010000086 Substrate specificity [chemical binding]; other site 279010000087 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279010000088 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279010000089 Substrate-binding site [chemical binding]; other site 279010000090 Substrate specificity [chemical binding]; other site 279010000091 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 279010000092 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010000093 putative peptidoglycan binding site; other site 279010000094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010000095 putative peptidoglycan binding site; other site 279010000096 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 279010000097 active site 279010000098 Isochorismatase family; Region: Isochorismatase; pfam00857 279010000099 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 279010000100 catalytic triad [active] 279010000101 conserved cis-peptide bond; other site 279010000102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 279010000103 nucleoside/Zn binding site; other site 279010000104 dimer interface [polypeptide binding]; other site 279010000105 catalytic motif [active] 279010000106 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 279010000107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000108 Walker A motif; other site 279010000109 ATP binding site [chemical binding]; other site 279010000110 Walker B motif; other site 279010000111 arginine finger; other site 279010000112 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 279010000113 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 279010000114 recombination protein RecR; Reviewed; Region: recR; PRK00076 279010000115 RecR protein; Region: RecR; pfam02132 279010000116 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 279010000117 putative active site [active] 279010000118 putative metal-binding site [ion binding]; other site 279010000119 tetramer interface [polypeptide binding]; other site 279010000120 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 279010000121 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 279010000122 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 279010000123 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 279010000124 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 279010000125 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 279010000126 homodimer interface [polypeptide binding]; other site 279010000127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000128 catalytic residue [active] 279010000129 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 279010000130 thymidylate kinase; Validated; Region: tmk; PRK00698 279010000131 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 279010000132 TMP-binding site; other site 279010000133 ATP-binding site [chemical binding]; other site 279010000134 Nitrogen regulatory protein P-II; Region: P-II; cl00412 279010000135 Protein of unknown function (DUF327); Region: DUF327; cl00753 279010000136 DNA polymerase III subunit delta'; Validated; Region: PRK08058 279010000137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010000138 PSP1 C-terminal conserved region; Region: PSP1; cl00770 279010000139 TSC-22/dip/bun family; Region: TSC22; cl01853 279010000140 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 279010000141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000142 S-adenosylmethionine binding site [chemical binding]; other site 279010000143 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 279010000144 GIY-YIG motif/motif A; other site 279010000145 putative active site [active] 279010000146 putative metal binding site [ion binding]; other site 279010000147 Predicted methyltransferases [General function prediction only]; Region: COG0313 279010000148 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 279010000149 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 279010000150 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 279010000151 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 279010000152 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 279010000153 active site 279010000154 HIGH motif; other site 279010000155 KMSKS motif; other site 279010000156 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 279010000157 tRNA binding surface [nucleotide binding]; other site 279010000158 anticodon binding site; other site 279010000159 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 279010000160 dimer interface [polypeptide binding]; other site 279010000161 putative tRNA-binding site [nucleotide binding]; other site 279010000162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 279010000163 active site 279010000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 279010000165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 279010000168 G5 domain; Region: G5; pfam07501 279010000169 3D domain; Region: 3D; cl01439 279010000170 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 279010000171 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279010000172 putative active site [active] 279010000173 putative metal binding site [ion binding]; other site 279010000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 279010000175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000176 S-adenosylmethionine binding site [chemical binding]; other site 279010000177 YabG peptidase U57; Region: Peptidase_U57; cl05250 279010000178 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 279010000179 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010000180 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 279010000181 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279010000182 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010000183 pur operon repressor; Provisional; Region: PRK09213 279010000184 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 279010000185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000186 active site 279010000187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010000188 homotrimer interaction site [polypeptide binding]; other site 279010000189 putative active site [active] 279010000190 SpoVG; Region: SpoVG; cl00915 279010000191 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 279010000192 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 279010000193 Substrate binding site; other site 279010000194 Mg++ binding site; other site 279010000195 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 279010000196 active site 279010000197 substrate binding site [chemical binding]; other site 279010000198 CoA binding site [chemical binding]; other site 279010000199 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 279010000200 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 279010000201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000202 active site 279010000203 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 279010000204 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 279010000205 5S rRNA interface [nucleotide binding]; other site 279010000206 CTC domain interface [polypeptide binding]; other site 279010000207 L16 interface [polypeptide binding]; other site 279010000208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 279010000209 putative active site [active] 279010000210 catalytic residue [active] 279010000211 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 279010000212 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 279010000213 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 279010000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010000215 ATP binding site [chemical binding]; other site 279010000216 putative Mg++ binding site [ion binding]; other site 279010000217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010000218 nucleotide binding region [chemical binding]; other site 279010000219 ATP-binding site [chemical binding]; other site 279010000220 TRCF domain; Region: TRCF; cl04088 279010000221 stage V sporulation protein T; Region: spore_V_T; TIGR02851 279010000222 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 279010000223 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 279010000224 MatE; Region: MatE; cl10513 279010000225 MatE; Region: MatE; cl10513 279010000226 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 279010000227 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 279010000228 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 279010000229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010000230 RNA binding surface [nucleotide binding]; other site 279010000231 YabP family; Region: YabP; cl06766 279010000232 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 279010000233 Septum formation initiator; Region: DivIC; cl11433 279010000234 hypothetical protein; Provisional; Region: PRK08582 279010000235 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 279010000236 RNA binding site [nucleotide binding]; other site 279010000237 stage II sporulation protein E; Region: spore_II_E; TIGR02865 279010000238 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 279010000239 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010000240 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010000241 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010000242 active site 279010000243 ATP binding site [chemical binding]; other site 279010000244 substrate binding site [chemical binding]; other site 279010000245 activation loop (A-loop); other site 279010000246 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 279010000247 Ligand Binding Site [chemical binding]; other site 279010000248 TilS substrate binding domain; Region: TilS; pfam09179 279010000249 B3/4 domain; Region: B3_4; cl11458 279010000250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010000251 active site 279010000252 FtsH Extracellular; Region: FtsH_ext; pfam06480 279010000253 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 279010000254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000255 Walker A motif; other site 279010000256 ATP binding site [chemical binding]; other site 279010000257 Walker B motif; other site 279010000258 arginine finger; other site 279010000259 Peptidase family M41; Region: Peptidase_M41; pfam01434 279010000260 Type III pantothenate kinase; Region: Pan_kinase; cl09130 279010000261 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 279010000262 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 279010000263 dimerization interface [polypeptide binding]; other site 279010000264 domain crossover interface; other site 279010000265 redox-dependent activation switch; other site 279010000266 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 279010000267 PPIC-type PPIASE domain; Region: Rotamase; cl08278 279010000268 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010000269 dimer interface [polypeptide binding]; other site 279010000270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000271 catalytic residue [active] 279010000272 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 279010000273 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 279010000274 chorismate binding enzyme; Region: Chorismate_bind; cl10555 279010000275 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 279010000276 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 279010000277 glutamine binding [chemical binding]; other site 279010000278 catalytic triad [active] 279010000279 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 279010000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010000281 catalytic residue [active] 279010000282 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 279010000283 dihydropteroate synthase; Region: DHPS; TIGR01496 279010000284 substrate binding pocket [chemical binding]; other site 279010000285 dimer interface [polypeptide binding]; other site 279010000286 inhibitor binding site; inhibition site 279010000287 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 279010000288 homooctamer interface [polypeptide binding]; other site 279010000289 active site 279010000290 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 279010000291 catalytic center binding site [active] 279010000292 ATP binding site [chemical binding]; other site 279010000293 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 279010000294 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 279010000295 FMN binding site [chemical binding]; other site 279010000296 active site 279010000297 catalytic residues [active] 279010000298 substrate binding site [chemical binding]; other site 279010000299 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 279010000300 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 279010000301 dimer interface [polypeptide binding]; other site 279010000302 putative anticodon binding site; other site 279010000303 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 279010000304 motif 1; other site 279010000305 active site 279010000306 motif 2; other site 279010000307 motif 3; other site 279010000308 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 279010000309 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 279010000310 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 279010000311 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 279010000312 ADP binding site [chemical binding]; other site 279010000313 phosphagen binding site; other site 279010000314 substrate specificity loop; other site 279010000315 Clp protease ATP binding subunit; Region: clpC; CHL00095 279010000316 Clp amino terminal domain; Region: Clp_N; pfam02861 279010000317 Clp amino terminal domain; Region: Clp_N; pfam02861 279010000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000319 Walker A motif; other site 279010000320 ATP binding site [chemical binding]; other site 279010000321 Walker B motif; other site 279010000322 arginine finger; other site 279010000323 UvrB/uvrC motif; Region: UVR; pfam02151 279010000324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010000325 Walker A motif; other site 279010000326 ATP binding site [chemical binding]; other site 279010000327 Walker B motif; other site 279010000328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 279010000329 DNA repair protein RadA; Provisional; Region: PRK11823 279010000330 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 279010000331 Walker A motif/ATP binding site; other site 279010000332 ATP binding site [chemical binding]; other site 279010000333 Walker B motif; other site 279010000334 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 279010000335 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 279010000336 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 279010000337 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 279010000338 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 279010000339 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 279010000340 putative active site [active] 279010000341 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 279010000342 substrate binding site; other site 279010000343 dimer interface; other site 279010000344 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 279010000345 homotrimer interaction site [polypeptide binding]; other site 279010000346 zinc binding site [ion binding]; other site 279010000347 CDP-binding sites; other site 279010000348 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 279010000349 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279010000350 HIGH motif; other site 279010000351 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279010000352 active site 279010000353 KMSKS motif; other site 279010000354 serine O-acetyltransferase; Region: cysE; TIGR01172 279010000355 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 279010000356 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 279010000357 trimer interface [polypeptide binding]; other site 279010000358 active site 279010000359 substrate binding site [chemical binding]; other site 279010000360 CoA binding site [chemical binding]; other site 279010000361 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 279010000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279010000363 active site 279010000364 HIGH motif; other site 279010000365 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279010000366 KMSKS motif; other site 279010000367 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 279010000368 tRNA binding surface [nucleotide binding]; other site 279010000369 anticodon binding site; other site 279010000370 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279010000371 active site 279010000372 metal binding site [ion binding]; metal-binding site 279010000373 dimerization interface [polypeptide binding]; other site 279010000374 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 279010000375 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 279010000376 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 279010000377 YacP-like NYN domain; Region: NYN_YacP; cl01491 279010000378 RNA polymerase factor sigma-70; Validated; Region: PRK08295 279010000379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010000380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 279010000381 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 279010000382 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 279010000383 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 279010000384 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 279010000385 putative homodimer interface [polypeptide binding]; other site 279010000386 KOW motif; Region: KOW; cl00354 279010000387 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 279010000388 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 279010000389 23S rRNA interface [nucleotide binding]; other site 279010000390 L7/L12 interface [polypeptide binding]; other site 279010000391 putative thiostrepton binding site; other site 279010000392 L25 interface [polypeptide binding]; other site 279010000393 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 279010000394 mRNA/rRNA interface [nucleotide binding]; other site 279010000395 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 279010000396 23S rRNA interface [nucleotide binding]; other site 279010000397 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 279010000398 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 279010000399 core dimer interface [polypeptide binding]; other site 279010000400 peripheral dimer interface [polypeptide binding]; other site 279010000401 L10 interface [polypeptide binding]; other site 279010000402 L11 interface [polypeptide binding]; other site 279010000403 putative EF-Tu interaction site [polypeptide binding]; other site 279010000404 putative EF-G interaction site [polypeptide binding]; other site 279010000405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000406 S-adenosylmethionine binding site [chemical binding]; other site 279010000407 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 279010000408 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 279010000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 279010000410 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 279010000411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 279010000412 RPB1 interaction site [polypeptide binding]; other site 279010000413 RPB10 interaction site [polypeptide binding]; other site 279010000414 RPB11 interaction site [polypeptide binding]; other site 279010000415 RPB3 interaction site [polypeptide binding]; other site 279010000416 RPB12 interaction site [polypeptide binding]; other site 279010000417 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 279010000418 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 279010000419 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 279010000420 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 279010000421 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 279010000422 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 279010000423 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 279010000424 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 279010000425 G-loop; other site 279010000426 DNA binding site [nucleotide binding] 279010000427 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 279010000428 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 279010000429 S17 interaction site [polypeptide binding]; other site 279010000430 S8 interaction site; other site 279010000431 16S rRNA interaction site [nucleotide binding]; other site 279010000432 streptomycin interaction site [chemical binding]; other site 279010000433 23S rRNA interaction site [nucleotide binding]; other site 279010000434 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 279010000435 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 279010000436 elongation factor G; Reviewed; Region: PRK00007 279010000437 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 279010000438 G1 box; other site 279010000439 putative GEF interaction site [polypeptide binding]; other site 279010000440 GTP/Mg2+ binding site [chemical binding]; other site 279010000441 Switch I region; other site 279010000442 G2 box; other site 279010000443 G3 box; other site 279010000444 Switch II region; other site 279010000445 G4 box; other site 279010000446 G5 box; other site 279010000447 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 279010000448 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 279010000449 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 279010000450 elongation factor Tu; Reviewed; Region: PRK00049 279010000451 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 279010000452 G1 box; other site 279010000453 GEF interaction site [polypeptide binding]; other site 279010000454 GTP/Mg2+ binding site [chemical binding]; other site 279010000455 Switch I region; other site 279010000456 G2 box; other site 279010000457 G3 box; other site 279010000458 Switch II region; other site 279010000459 G4 box; other site 279010000460 G5 box; other site 279010000461 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 279010000462 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 279010000463 Antibiotic Binding Site [chemical binding]; other site 279010000464 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 279010000465 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 279010000466 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 279010000467 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 279010000468 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 279010000469 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 279010000470 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 279010000471 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 279010000472 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 279010000473 putative translocon binding site; other site 279010000474 protein-rRNA interface [nucleotide binding]; other site 279010000475 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 279010000476 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 279010000477 G-X-X-G motif; other site 279010000478 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 279010000479 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 279010000480 23S rRNA interface [nucleotide binding]; other site 279010000481 5S rRNA interface [nucleotide binding]; other site 279010000482 putative antibiotic binding site [chemical binding]; other site 279010000483 L25 interface [polypeptide binding]; other site 279010000484 L27 interface [polypeptide binding]; other site 279010000485 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 279010000486 23S rRNA interface [nucleotide binding]; other site 279010000487 putative translocon interaction site; other site 279010000488 signal recognition particle (SRP54) interaction site; other site 279010000489 L23 interface [polypeptide binding]; other site 279010000490 trigger factor interaction site; other site 279010000491 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 279010000492 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 279010000493 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 279010000494 KOW motif; Region: KOW; cl00354 279010000495 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 279010000496 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 279010000497 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 279010000498 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 279010000499 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 279010000500 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 279010000501 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279010000502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279010000503 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 279010000504 5S rRNA interface [nucleotide binding]; other site 279010000505 L27 interface [polypeptide binding]; other site 279010000506 23S rRNA interface [nucleotide binding]; other site 279010000507 L5 interface [polypeptide binding]; other site 279010000508 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 279010000509 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 279010000510 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 279010000511 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 279010000512 23S rRNA binding site [nucleotide binding]; other site 279010000513 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 279010000514 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 279010000515 SecY translocase; Region: SecY; pfam00344 279010000516 adenylate kinase; Reviewed; Region: adk; PRK00279 279010000517 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 279010000518 AMP-binding site [chemical binding]; other site 279010000519 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 279010000520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 279010000521 active site 279010000522 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 279010000523 rRNA binding site [nucleotide binding]; other site 279010000524 predicted 30S ribosome binding site; other site 279010000525 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 279010000526 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 279010000527 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 279010000528 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 279010000529 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 279010000530 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 279010000531 alphaNTD homodimer interface [polypeptide binding]; other site 279010000532 alphaNTD - beta interaction site [polypeptide binding]; other site 279010000533 alphaNTD - beta' interaction site [polypeptide binding]; other site 279010000534 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 279010000535 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 279010000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 279010000537 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 279010000538 Walker A/P-loop; other site 279010000539 ATP binding site [chemical binding]; other site 279010000540 Q-loop/lid; other site 279010000541 ABC transporter signature motif; other site 279010000542 Walker B; other site 279010000543 D-loop; other site 279010000544 H-loop/switch region; other site 279010000545 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 279010000546 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 279010000547 Walker A/P-loop; other site 279010000548 ATP binding site [chemical binding]; other site 279010000549 Q-loop/lid; other site 279010000550 ABC transporter signature motif; other site 279010000551 Walker B; other site 279010000552 D-loop; other site 279010000553 H-loop/switch region; other site 279010000554 Cobalt transport protein; Region: CbiQ; cl00463 279010000555 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 279010000556 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 279010000557 dimerization interface 3.5A [polypeptide binding]; other site 279010000558 active site 279010000559 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 279010000560 23S rRNA interface [nucleotide binding]; other site 279010000561 L3 interface [polypeptide binding]; other site 279010000562 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 279010000563 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010000564 DinB superfamily; Region: DinB_2; pfam12867 279010000565 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 279010000566 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010000567 active site 279010000568 metal binding site [ion binding]; metal-binding site 279010000569 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 279010000570 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 279010000571 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279010000572 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 279010000573 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000574 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 279010000575 Membrane transport protein; Region: Mem_trans; cl09117 279010000576 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 279010000577 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 279010000578 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 279010000579 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 279010000580 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 279010000581 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 279010000582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010000584 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 279010000585 active site turn [active] 279010000586 phosphorylation site [posttranslational modification] 279010000587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010000588 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010000589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010000590 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010000591 putative active site [active] 279010000592 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 279010000593 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 279010000594 putative active site [active] 279010000595 Protein of unknown function (DUF523); Region: DUF523; cl00733 279010000596 Arginase family; Region: Arginase; cl00306 279010000597 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 279010000598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010000599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010000600 DNA binding residues [nucleotide binding] 279010000601 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 279010000602 Putative zinc-finger; Region: zf-HC2; cl15806 279010000603 TIGR00159 family protein; Region: TIGR00159 279010000604 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 279010000605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 279010000606 YbbR-like protein; Region: YbbR; pfam07949 279010000607 YbbR-like protein; Region: YbbR; pfam07949 279010000608 YbbR-like protein; Region: YbbR; pfam07949 279010000609 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 279010000610 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 279010000611 active site 279010000612 substrate binding site [chemical binding]; other site 279010000613 metal binding site [ion binding]; metal-binding site 279010000614 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 279010000615 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 279010000616 glutaminase active site [active] 279010000617 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 279010000618 dimer interface [polypeptide binding]; other site 279010000619 active site 279010000620 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 279010000621 dimer interface [polypeptide binding]; other site 279010000622 active site 279010000623 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 279010000624 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279010000625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010000626 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010000627 Walker A/P-loop; other site 279010000628 ATP binding site [chemical binding]; other site 279010000629 Q-loop/lid; other site 279010000630 ABC transporter signature motif; other site 279010000631 Walker B; other site 279010000632 D-loop; other site 279010000633 H-loop/switch region; other site 279010000634 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010000635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010000636 DNA-binding site [nucleotide binding]; DNA binding site 279010000637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010000638 dimerization interface [polypeptide binding]; other site 279010000639 putative DNA binding site [nucleotide binding]; other site 279010000640 putative Zn2+ binding site [ion binding]; other site 279010000641 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010000642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000643 putative substrate translocation pore; other site 279010000644 DinB superfamily; Region: DinB_2; pfam12867 279010000645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010000646 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010000647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010000648 Walker A/P-loop; other site 279010000649 ATP binding site [chemical binding]; other site 279010000650 Q-loop/lid; other site 279010000651 ABC transporter signature motif; other site 279010000652 Walker B; other site 279010000653 D-loop; other site 279010000654 H-loop/switch region; other site 279010000655 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 279010000656 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 279010000657 catalytic residues [active] 279010000658 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279010000659 putative hydrophobic ligand binding site [chemical binding]; other site 279010000660 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 279010000661 Phosphotransferase enzyme family; Region: APH; pfam01636 279010000662 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010000663 active site 279010000664 ATP binding site [chemical binding]; other site 279010000665 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010000666 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 279010000667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010000668 active site 279010000669 motif I; other site 279010000670 motif II; other site 279010000671 putative transport protein YifK; Provisional; Region: PRK10746 279010000672 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 279010000673 Citrate transporter; Region: CitMHS; pfam03600 279010000674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 279010000675 NMT1-like family; Region: NMT1_2; cl15260 279010000676 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010000677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000678 active site 279010000679 phosphorylation site [posttranslational modification] 279010000680 intermolecular recognition site; other site 279010000681 dimerization interface [polypeptide binding]; other site 279010000682 Transcriptional regulator; Region: CitT; pfam12431 279010000683 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010000684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010000685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000686 ATP binding site [chemical binding]; other site 279010000687 Mg2+ binding site [ion binding]; other site 279010000688 G-X-G motif; other site 279010000689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010000690 Helix-turn-helix domains; Region: HTH; cl00088 279010000691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010000692 dimerization interface [polypeptide binding]; other site 279010000693 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010000694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000695 putative transporter; Provisional; Region: PRK10054 279010000696 putative substrate translocation pore; other site 279010000697 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 279010000698 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 279010000699 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 279010000700 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 279010000701 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 279010000702 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 279010000703 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010000704 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 279010000705 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279010000706 active site 279010000707 dimer interface [polypeptide binding]; other site 279010000708 motif 1; other site 279010000709 motif 2; other site 279010000710 motif 3; other site 279010000711 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279010000712 anticodon binding site; other site 279010000713 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000715 Protein of unknown function (DUF692); Region: DUF692; cl01263 279010000716 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010000717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010000718 Transporter associated domain; Region: CorC_HlyC; cl08393 279010000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000720 putative substrate translocation pore; other site 279010000721 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 279010000722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000723 S-adenosylmethionine binding site [chemical binding]; other site 279010000724 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 279010000725 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 279010000726 NADP binding site [chemical binding]; other site 279010000727 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 279010000728 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 279010000729 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010000730 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010000731 PhoU domain; Region: PhoU; pfam01895 279010000732 PhoU domain; Region: PhoU; pfam01895 279010000733 yiaA/B two helix domain; Region: YiaAB; cl01759 279010000734 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 279010000735 EamA-like transporter family; Region: EamA; cl01037 279010000736 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010000737 EamA-like transporter family; Region: EamA; cl01037 279010000738 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010000739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010000740 Cupin domain; Region: Cupin_2; cl09118 279010000741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010000742 non-specific DNA binding site [nucleotide binding]; other site 279010000743 salt bridge; other site 279010000744 sequence-specific DNA binding site [nucleotide binding]; other site 279010000745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010000746 DNA binding residues [nucleotide binding] 279010000747 dimerization interface [polypeptide binding]; other site 279010000748 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010000749 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 279010000750 putative active site [active] 279010000751 metal binding site [ion binding]; metal-binding site 279010000752 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 279010000753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010000754 dimerization interface [polypeptide binding]; other site 279010000755 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010000756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010000757 dimer interface [polypeptide binding]; other site 279010000758 putative CheW interface [polypeptide binding]; other site 279010000759 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 279010000760 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 279010000761 putative ligand binding site [chemical binding]; other site 279010000762 SurA N-terminal domain; Region: SurA_N_3; cl07813 279010000763 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 279010000764 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 279010000765 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 279010000766 S-methylmethionine transporter; Provisional; Region: PRK11387 279010000767 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 279010000768 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 279010000769 YdjC-like protein; Region: YdjC; cl01344 279010000770 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 279010000771 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010000772 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010000773 active site turn [active] 279010000774 phosphorylation site [posttranslational modification] 279010000775 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010000776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010000777 DNA binding residues [nucleotide binding] 279010000778 dimer interface [polypeptide binding]; other site 279010000779 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 279010000780 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010000781 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 279010000782 trimer interface [polypeptide binding]; other site 279010000783 active site 279010000784 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 279010000785 Glutaminase; Region: Glutaminase; cl00907 279010000786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010000787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000788 ATP binding site [chemical binding]; other site 279010000789 Mg2+ binding site [ion binding]; other site 279010000790 G-X-G motif; other site 279010000791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000792 Response regulator receiver domain; Region: Response_reg; pfam00072 279010000793 active site 279010000794 phosphorylation site [posttranslational modification] 279010000795 intermolecular recognition site; other site 279010000796 dimerization interface [polypeptide binding]; other site 279010000797 YcbB domain; Region: YcbB; pfam08664 279010000798 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010000799 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010000800 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 279010000801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000802 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 279010000803 Helix-turn-helix domains; Region: HTH; cl00088 279010000804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000805 PhoD-like phosphatase; Region: PhoD; pfam09423 279010000806 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010000807 putative active site [active] 279010000808 putative metal binding site [ion binding]; other site 279010000809 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010000810 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 279010000811 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 279010000812 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 279010000813 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010000814 putative active site [active] 279010000815 catalytic residue [active] 279010000816 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 279010000817 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010000818 NAD(P) binding site [chemical binding]; other site 279010000819 catalytic residues [active] 279010000820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010000821 D-galactonate transporter; Region: 2A0114; TIGR00893 279010000822 putative substrate translocation pore; other site 279010000823 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 279010000824 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 279010000825 active site 279010000826 tetramer interface [polypeptide binding]; other site 279010000827 Transcriptional regulators [Transcription]; Region: FadR; COG2186 279010000828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010000829 DNA-binding site [nucleotide binding]; DNA binding site 279010000830 FCD domain; Region: FCD; cl11656 279010000831 galactarate dehydratase; Region: galactar-dH20; TIGR03248 279010000832 SAF domain; Region: SAF; cl00555 279010000833 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 279010000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 279010000835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000836 active site 279010000837 phosphorylation site [posttranslational modification] 279010000838 intermolecular recognition site; other site 279010000839 dimerization interface [polypeptide binding]; other site 279010000840 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010000841 DNA binding site [nucleotide binding] 279010000842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010000843 dimer interface [polypeptide binding]; other site 279010000844 phosphorylation site [posttranslational modification] 279010000845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010000846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000847 ATP binding site [chemical binding]; other site 279010000848 Mg2+ binding site [ion binding]; other site 279010000849 G-X-G motif; other site 279010000850 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010000851 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 279010000852 Walker A/P-loop; other site 279010000853 ATP binding site [chemical binding]; other site 279010000854 Q-loop/lid; other site 279010000855 ABC transporter signature motif; other site 279010000856 Walker B; other site 279010000857 D-loop; other site 279010000858 H-loop/switch region; other site 279010000859 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 279010000860 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 279010000861 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 279010000862 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 279010000863 putative active site [active] 279010000864 putative substrate binding site [chemical binding]; other site 279010000865 ATP binding site [chemical binding]; other site 279010000866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010000867 Helix-turn-helix domains; Region: HTH; cl00088 279010000868 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 279010000869 AMP-binding enzyme; Region: AMP-binding; cl15778 279010000870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010000871 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 279010000872 serpin-like protein; Provisional; Region: PHA02660 279010000873 reactive center loop; other site 279010000874 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 279010000875 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010000876 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010000877 DNA binding residues [nucleotide binding] 279010000878 dimer interface [polypeptide binding]; other site 279010000879 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 279010000880 Helix-turn-helix domains; Region: HTH; cl00088 279010000881 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 279010000882 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 279010000883 dodecamer interface 2 [polypeptide binding]; other site 279010000884 dodecamer interface 1 [polypeptide binding]; other site 279010000885 trimer interface [polypeptide binding]; other site 279010000886 TRAP binding interface [polypeptide binding]; other site 279010000887 Zn binding site [ion binding]; other site 279010000888 EamA-like transporter family; Region: EamA; cl01037 279010000889 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010000890 EamA-like transporter family; Region: EamA; cl01037 279010000891 RDD family; Region: RDD; cl00746 279010000892 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 279010000893 SEC-C motif; Region: SEC-C; pfam02810 279010000894 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 279010000895 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 279010000896 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 279010000897 Walker A/P-loop; other site 279010000898 ATP binding site [chemical binding]; other site 279010000899 Q-loop/lid; other site 279010000900 ABC transporter signature motif; other site 279010000901 Walker B; other site 279010000902 D-loop; other site 279010000903 H-loop/switch region; other site 279010000904 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010000905 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010000906 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010000907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010000908 active site 279010000909 phosphorylation site [posttranslational modification] 279010000910 intermolecular recognition site; other site 279010000911 dimerization interface [polypeptide binding]; other site 279010000912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010000913 DNA binding site [nucleotide binding] 279010000914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010000915 dimer interface [polypeptide binding]; other site 279010000916 phosphorylation site [posttranslational modification] 279010000917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010000918 ATP binding site [chemical binding]; other site 279010000919 Mg2+ binding site [ion binding]; other site 279010000920 G-X-G motif; other site 279010000921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010000922 Helix-turn-helix domains; Region: HTH; cl00088 279010000923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010000924 dimerization interface [polypeptide binding]; other site 279010000925 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 279010000926 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010000927 classical (c) SDRs; Region: SDR_c; cd05233 279010000928 NAD(P) binding site [chemical binding]; other site 279010000929 active site 279010000930 hypothetical protein; Provisional; Region: PRK06922 279010000931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010000932 S-adenosylmethionine binding site [chemical binding]; other site 279010000933 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279010000934 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 279010000935 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010000936 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 279010000937 metal binding site [ion binding]; metal-binding site 279010000938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010000939 Coenzyme A binding pocket [chemical binding]; other site 279010000940 amidase; Provisional; Region: PRK06529 279010000941 Amidase; Region: Amidase; cl11426 279010000942 oligoendopeptidase F; Region: pepF; TIGR00181 279010000943 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 279010000944 active site 279010000945 Zn binding site [ion binding]; other site 279010000946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010000947 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010000948 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010000949 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 279010000950 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 279010000951 Cysteine-rich domain; Region: CCG; pfam02754 279010000952 Cysteine-rich domain; Region: CCG; pfam02754 279010000953 FAD binding domain; Region: FAD_binding_4; pfam01565 279010000954 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 279010000955 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010000956 active site 279010000957 P-loop; other site 279010000958 phosphorylation site [posttranslational modification] 279010000959 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279010000960 methionine cluster; other site 279010000961 active site 279010000962 phosphorylation site [posttranslational modification] 279010000963 metal binding site [ion binding]; metal-binding site 279010000964 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010000965 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010000966 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010000967 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 279010000968 NAD binding site [chemical binding]; other site 279010000969 sugar binding site [chemical binding]; other site 279010000970 divalent metal binding site [ion binding]; other site 279010000971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010000972 dimer interface [polypeptide binding]; other site 279010000973 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010000974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010000975 DNA-binding site [nucleotide binding]; DNA binding site 279010000976 UTRA domain; Region: UTRA; cl01230 279010000977 YdjC-like protein; Region: YdjC; cl01344 279010000978 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 279010000979 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 279010000980 active site 279010000981 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010000982 Interdomain contacts; other site 279010000983 Cytokine receptor motif; other site 279010000984 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 279010000985 chitin/cellulose binding site [chemical binding]; other site 279010000986 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 279010000987 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 279010000988 active site 279010000989 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 279010000990 Chitinase C; Region: ChiC; pfam06483 279010000991 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 279010000992 active site 279010000993 glucose-1-dehydrogenase; Provisional; Region: PRK08936 279010000994 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 279010000995 NAD binding site [chemical binding]; other site 279010000996 homodimer interface [polypeptide binding]; other site 279010000997 active site 279010000998 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 279010000999 Protein of unknown function; Region: DUF3658; pfam12395 279010001000 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 279010001001 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 279010001002 active site residue [active] 279010001003 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 279010001004 active site residue [active] 279010001005 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010001006 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 279010001007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279010001008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 279010001009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 279010001010 NlpC/P60 family; Region: NLPC_P60; cl11438 279010001011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010001012 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010001013 Walker A/P-loop; other site 279010001014 ATP binding site [chemical binding]; other site 279010001015 Q-loop/lid; other site 279010001016 ABC transporter signature motif; other site 279010001017 Walker B; other site 279010001018 D-loop; other site 279010001019 H-loop/switch region; other site 279010001020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001021 Helix-turn-helix domains; Region: HTH; cl00088 279010001022 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 279010001023 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 279010001024 Helix-turn-helix domains; Region: HTH; cl00088 279010001025 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 279010001026 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001027 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001028 putative metal binding site [ion binding]; other site 279010001029 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001030 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001031 putative metal binding site [ion binding]; other site 279010001032 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 279010001033 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 279010001034 putative metal binding site [ion binding]; other site 279010001035 Integral membrane protein TerC family; Region: TerC; cl10468 279010001036 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 279010001037 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 279010001038 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 279010001039 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 279010001040 CAAX protease self-immunity; Region: Abi; cl00558 279010001041 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010001042 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010001043 DNA binding residues [nucleotide binding] 279010001044 dimer interface [polypeptide binding]; other site 279010001045 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 279010001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001047 putative substrate translocation pore; other site 279010001048 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 279010001049 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 279010001050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010001051 NAD binding site [chemical binding]; other site 279010001052 dimer interface [polypeptide binding]; other site 279010001053 substrate binding site [chemical binding]; other site 279010001054 glycolate transporter; Provisional; Region: PRK09695 279010001055 L-lactate permease; Region: Lactate_perm; cl00701 279010001056 LysE type translocator; Region: LysE; cl00565 279010001057 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279010001058 Spore germination protein; Region: Spore_permease; cl15802 279010001059 NAD+ synthetase; Region: nadE; TIGR00552 279010001060 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 279010001061 homodimer interface [polypeptide binding]; other site 279010001062 NAD binding pocket [chemical binding]; other site 279010001063 ATP binding pocket [chemical binding]; other site 279010001064 Mg binding site [ion binding]; other site 279010001065 active-site loop [active] 279010001066 shikimate kinase; Reviewed; Region: aroK; PRK00131 279010001067 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 279010001068 ADP binding site [chemical binding]; other site 279010001069 magnesium binding site [ion binding]; other site 279010001070 putative shikimate binding site; other site 279010001071 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 279010001072 Proline dehydrogenase; Region: Pro_dh; cl03282 279010001073 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 279010001074 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 279010001075 Glutamate binding site [chemical binding]; other site 279010001076 homodimer interface [polypeptide binding]; other site 279010001077 NAD binding site [chemical binding]; other site 279010001078 catalytic residues [active] 279010001079 Sodium:solute symporter family; Region: SSF; cl00456 279010001080 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010001081 Helix-turn-helix domains; Region: HTH; cl00088 279010001082 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 279010001083 Predicted permeases [General function prediction only]; Region: COG0701 279010001084 Predicted permease; Region: DUF318; pfam03773 279010001085 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 279010001086 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010001087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010001088 Helix-turn-helix domains; Region: HTH; cl00088 279010001089 hypothetical protein; Provisional; Region: PRK09272 279010001090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279010001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001092 dimer interface [polypeptide binding]; other site 279010001093 conserved gate region; other site 279010001094 putative PBP binding loops; other site 279010001095 ABC-ATPase subunit interface; other site 279010001096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279010001097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010001098 substrate binding pocket [chemical binding]; other site 279010001099 membrane-bound complex binding site; other site 279010001100 hinge residues; other site 279010001101 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010001102 Predicted ATPase [General function prediction only]; Region: COG3910 279010001103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010001104 Walker A/P-loop; other site 279010001105 ATP binding site [chemical binding]; other site 279010001106 Q-loop/lid; other site 279010001107 ABC transporter signature motif; other site 279010001108 Walker B; other site 279010001109 D-loop; other site 279010001110 H-loop/switch region; other site 279010001111 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010001112 Competence protein J (ComJ); Region: ComJ; pfam11033 279010001113 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 279010001114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 279010001115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 279010001116 active site 279010001117 ATP binding site [chemical binding]; other site 279010001118 substrate binding site [chemical binding]; other site 279010001119 activation loop (A-loop); other site 279010001120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001121 putative CheW interface [polypeptide binding]; other site 279010001122 dimer interface [polypeptide binding]; other site 279010001123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001124 dimerization interface [polypeptide binding]; other site 279010001125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001127 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010001128 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 279010001129 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 279010001130 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 279010001131 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010001132 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 279010001133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010001134 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 279010001135 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 279010001136 Walker A/P-loop; other site 279010001137 ATP binding site [chemical binding]; other site 279010001138 Q-loop/lid; other site 279010001139 ABC transporter signature motif; other site 279010001140 Walker B; other site 279010001141 D-loop; other site 279010001142 H-loop/switch region; other site 279010001143 TOBE domain; Region: TOBE_2; cl01440 279010001144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001145 dimer interface [polypeptide binding]; other site 279010001146 conserved gate region; other site 279010001147 putative PBP binding loops; other site 279010001148 ABC-ATPase subunit interface; other site 279010001149 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 279010001150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001151 dimer interface [polypeptide binding]; other site 279010001152 conserved gate region; other site 279010001153 putative PBP binding loops; other site 279010001154 ABC-ATPase subunit interface; other site 279010001155 peptide synthase; Provisional; Region: PRK12467 279010001156 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001157 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001158 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001159 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001160 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001161 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001162 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001163 peptide synthase; Provisional; Region: PRK12316 279010001164 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001165 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001166 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001167 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 279010001168 peptide synthase; Provisional; Region: PRK12467 279010001169 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001170 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001171 peptide synthase; Provisional; Region: PRK12467 279010001172 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001173 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001174 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001175 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010001176 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001177 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001178 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 279010001179 peptide synthase; Provisional; Region: PRK12467 279010001180 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001181 AMP-binding enzyme; Region: AMP-binding; cl15778 279010001182 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010001183 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 279010001184 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 279010001185 EamA-like transporter family; Region: EamA; cl01037 279010001186 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001187 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010001188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001189 DNA-binding site [nucleotide binding]; DNA binding site 279010001190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010001191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001192 homodimer interface [polypeptide binding]; other site 279010001193 catalytic residue [active] 279010001194 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 279010001195 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 279010001196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010001197 Putative esterase; Region: Esterase; pfam00756 279010001198 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010001199 Predicted membrane protein [Function unknown]; Region: COG2364 279010001200 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001201 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 279010001202 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010001203 Walker A/P-loop; other site 279010001204 ATP binding site [chemical binding]; other site 279010001205 Q-loop/lid; other site 279010001206 ABC transporter signature motif; other site 279010001207 Walker B; other site 279010001208 D-loop; other site 279010001209 H-loop/switch region; other site 279010001210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010001211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010001212 catalytic residue [active] 279010001213 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010001214 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 279010001215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001216 dimerization interface [polypeptide binding]; other site 279010001217 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010001218 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001219 dimer interface [polypeptide binding]; other site 279010001220 putative CheW interface [polypeptide binding]; other site 279010001221 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279010001222 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 279010001223 Walker A/P-loop; other site 279010001224 ATP binding site [chemical binding]; other site 279010001225 Q-loop/lid; other site 279010001226 ABC transporter signature motif; other site 279010001227 Walker B; other site 279010001228 D-loop; other site 279010001229 H-loop/switch region; other site 279010001230 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279010001231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001232 dimer interface [polypeptide binding]; other site 279010001233 conserved gate region; other site 279010001234 putative PBP binding loops; other site 279010001235 ABC-ATPase subunit interface; other site 279010001236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279010001237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010001238 substrate binding pocket [chemical binding]; other site 279010001239 membrane-bound complex binding site; other site 279010001240 hinge residues; other site 279010001241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010001242 sensory histidine kinase AtoS; Provisional; Region: PRK11360 279010001243 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 279010001244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010001245 Walker A motif; other site 279010001246 ATP binding site [chemical binding]; other site 279010001247 Walker B motif; other site 279010001248 arginine finger; other site 279010001249 Helix-turn-helix domains; Region: HTH; cl00088 279010001250 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 279010001251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010001252 inhibitor-cofactor binding pocket; inhibition site 279010001253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001254 catalytic residue [active] 279010001255 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 279010001256 Spore germination protein; Region: Spore_permease; cl15802 279010001257 Arginase family; Region: Arginase; cl00306 279010001258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010001259 Helix-turn-helix domains; Region: HTH; cl00088 279010001260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010001261 dimerization interface [polypeptide binding]; other site 279010001262 aromatic acid decarboxylase; Validated; Region: PRK05920 279010001263 Flavoprotein; Region: Flavoprotein; cl08021 279010001264 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 279010001265 50S ribosomal protein L37Ae; Reviewed; Region: rpl37ae; PRK03976 279010001266 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 279010001267 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010001268 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 279010001269 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 279010001270 ligand binding site [chemical binding]; other site 279010001271 Cache domain; Region: Cache_1; pfam02743 279010001272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010001273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001274 dimerization interface [polypeptide binding]; other site 279010001275 Histidine kinase; Region: His_kinase; pfam06580 279010001276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001277 ATP binding site [chemical binding]; other site 279010001278 Mg2+ binding site [ion binding]; other site 279010001279 G-X-G motif; other site 279010001280 Response regulator receiver domain; Region: Response_reg; pfam00072 279010001281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001282 active site 279010001283 phosphorylation site [posttranslational modification] 279010001284 intermolecular recognition site; other site 279010001285 dimerization interface [polypeptide binding]; other site 279010001286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010001287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010001288 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 279010001289 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 279010001290 putative ligand binding site [chemical binding]; other site 279010001291 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 279010001292 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 279010001293 Walker A/P-loop; other site 279010001294 ATP binding site [chemical binding]; other site 279010001295 Q-loop/lid; other site 279010001296 ABC transporter signature motif; other site 279010001297 Walker B; other site 279010001298 D-loop; other site 279010001299 H-loop/switch region; other site 279010001300 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 279010001301 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 279010001302 TM-ABC transporter signature motif; other site 279010001303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010001305 putative substrate translocation pore; other site 279010001306 Helix-turn-helix domains; Region: HTH; cl00088 279010001307 Helix-turn-helix domains; Region: HTH; cl00088 279010001308 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010001309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001310 Coenzyme A binding pocket [chemical binding]; other site 279010001311 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010001312 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 279010001313 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010001314 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010001315 Phytase; Region: Phytase; pfam02333 279010001316 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 279010001317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001318 putative substrate translocation pore; other site 279010001319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 279010001320 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010001321 Right handed beta helix region; Region: Beta_helix; pfam13229 279010001322 Right handed beta helix region; Region: Beta_helix; pfam13229 279010001323 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 279010001324 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010001325 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 279010001326 Spore germination protein; Region: Spore_permease; cl15802 279010001327 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279010001328 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010001329 DNA binding residues [nucleotide binding] 279010001330 dimer interface [polypeptide binding]; other site 279010001331 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010001332 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010001333 Walker A/P-loop; other site 279010001334 ATP binding site [chemical binding]; other site 279010001335 Q-loop/lid; other site 279010001336 ABC transporter signature motif; other site 279010001337 Walker B; other site 279010001338 D-loop; other site 279010001339 H-loop/switch region; other site 279010001340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010001341 FtsX-like permease family; Region: FtsX; cl15850 279010001342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010001343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001344 active site 279010001345 phosphorylation site [posttranslational modification] 279010001346 intermolecular recognition site; other site 279010001347 dimerization interface [polypeptide binding]; other site 279010001348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010001349 DNA binding site [nucleotide binding] 279010001350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010001351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010001352 dimerization interface [polypeptide binding]; other site 279010001353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010001354 dimer interface [polypeptide binding]; other site 279010001355 phosphorylation site [posttranslational modification] 279010001356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001357 ATP binding site [chemical binding]; other site 279010001358 Mg2+ binding site [ion binding]; other site 279010001359 G-X-G motif; other site 279010001360 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 279010001361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 279010001362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010001363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010001364 dimer interface [polypeptide binding]; other site 279010001365 putative CheW interface [polypeptide binding]; other site 279010001366 aspartate kinase; Reviewed; Region: PRK09034 279010001367 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 279010001368 putative catalytic residues [active] 279010001369 putative nucleotide binding site [chemical binding]; other site 279010001370 putative aspartate binding site [chemical binding]; other site 279010001371 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 279010001372 allosteric regulatory residue; other site 279010001373 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 279010001374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010001375 ABC-ATPase subunit interface; other site 279010001376 dimer interface [polypeptide binding]; other site 279010001377 putative PBP binding regions; other site 279010001378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010001379 ABC-ATPase subunit interface; other site 279010001380 dimer interface [polypeptide binding]; other site 279010001381 putative PBP binding regions; other site 279010001382 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 279010001383 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010001384 Walker A/P-loop; other site 279010001385 ATP binding site [chemical binding]; other site 279010001386 Q-loop/lid; other site 279010001387 ABC transporter signature motif; other site 279010001388 Walker B; other site 279010001389 D-loop; other site 279010001390 H-loop/switch region; other site 279010001391 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 279010001392 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 279010001393 putative ligand binding residues [chemical binding]; other site 279010001394 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010001395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001396 putative substrate translocation pore; other site 279010001397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001399 Helix-turn-helix domains; Region: HTH; cl00088 279010001400 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 279010001401 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010001402 tetramer interface [polypeptide binding]; other site 279010001403 active site 279010001404 Mg2+/Mn2+ binding site [ion binding]; other site 279010001405 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 279010001406 dimer interface [polypeptide binding]; other site 279010001407 FMN binding site [chemical binding]; other site 279010001408 NADPH bind site [chemical binding]; other site 279010001409 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 279010001410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010001411 dimerization interface [polypeptide binding]; other site 279010001412 putative DNA binding site [nucleotide binding]; other site 279010001413 putative Zn2+ binding site [ion binding]; other site 279010001414 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010001415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001416 DNA-binding site [nucleotide binding]; DNA binding site 279010001417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010001418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001419 homodimer interface [polypeptide binding]; other site 279010001420 catalytic residue [active] 279010001421 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 279010001422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010001423 inhibitor-cofactor binding pocket; inhibition site 279010001424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010001425 catalytic residue [active] 279010001426 amino acid transporter; Region: 2A0306; TIGR00909 279010001427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010001428 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 279010001429 tetramerization interface [polypeptide binding]; other site 279010001430 NAD(P) binding site [chemical binding]; other site 279010001431 catalytic residues [active] 279010001432 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001433 EamA-like transporter family; Region: EamA; cl01037 279010001434 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 279010001435 Bacterial Ig-like domain; Region: Big_5; cl01012 279010001436 Copper resistance protein D; Region: CopD; cl00563 279010001437 FixH; Region: FixH; cl01254 279010001438 Helix-turn-helix domains; Region: HTH; cl00088 279010001439 NosL; Region: NosL; cl01769 279010001440 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 279010001441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010001442 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 279010001443 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 279010001444 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010001445 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 279010001446 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 279010001447 [4Fe-4S] binding site [ion binding]; other site 279010001448 molybdopterin cofactor binding site; other site 279010001449 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 279010001450 molybdopterin cofactor binding site; other site 279010001451 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 279010001452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010001453 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 279010001454 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 279010001455 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010001456 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 279010001457 [2Fe-2S] cluster binding site [ion binding]; other site 279010001458 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 279010001459 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 279010001460 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010001461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010001462 DNA-binding site [nucleotide binding]; DNA binding site 279010001463 FCD domain; Region: FCD; cl11656 279010001464 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010001465 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 279010001466 transmembrane helices; other site 279010001467 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 279010001468 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 279010001469 dimer interface [polypeptide binding]; other site 279010001470 active site 2 [active] 279010001471 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 279010001472 homodimer interaction site [polypeptide binding]; other site 279010001473 cofactor binding site; other site 279010001474 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010001475 Helix-turn-helix domains; Region: HTH; cl00088 279010001476 PRD domain; Region: PRD; cl15445 279010001477 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010001478 P-loop; other site 279010001479 active site 279010001480 phosphorylation site [posttranslational modification] 279010001481 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010001482 active site 279010001483 phosphorylation site [posttranslational modification] 279010001484 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 279010001485 P-loop; other site 279010001486 active site 279010001487 phosphorylation site [posttranslational modification] 279010001488 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 279010001489 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 279010001490 TPP-binding site [chemical binding]; other site 279010001491 dimer interface [polypeptide binding]; other site 279010001492 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 279010001493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010001494 PYR/PP interface [polypeptide binding]; other site 279010001495 dimer interface [polypeptide binding]; other site 279010001496 TPP binding site [chemical binding]; other site 279010001497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010001498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010001499 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010001500 active site 279010001501 motif I; other site 279010001502 motif II; other site 279010001503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010001504 LamB/YcsF family; Region: LamB_YcsF; cl00664 279010001505 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 279010001506 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 279010001507 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 279010001508 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 279010001509 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 279010001510 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010001511 Helix-turn-helix domains; Region: HTH; cl00088 279010001512 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010001513 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 279010001514 active site 279010001515 catalytic triad [active] 279010001516 oxyanion hole [active] 279010001517 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 279010001518 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010001519 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 279010001520 active site 279010001521 P-loop; other site 279010001522 phosphorylation site [posttranslational modification] 279010001523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010001524 active site 279010001525 phosphorylation site [posttranslational modification] 279010001526 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 279010001527 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 279010001528 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 279010001529 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010001530 Helix-turn-helix domains; Region: HTH; cl00088 279010001531 Helix-turn-helix domains; Region: HTH; cl00088 279010001532 PRD domain; Region: PRD; cl15445 279010001533 PRD domain; Region: PRD; cl15445 279010001534 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010001535 P-loop; other site 279010001536 active site 279010001537 phosphorylation site [posttranslational modification] 279010001538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 279010001539 short chain dehydrogenase; Provisional; Region: PRK06701 279010001540 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010001541 NAD binding site [chemical binding]; other site 279010001542 metal binding site [ion binding]; metal-binding site 279010001543 active site 279010001544 Cupin domain; Region: Cupin_2; cl09118 279010001545 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 279010001546 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 279010001547 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 279010001548 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 279010001549 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010001550 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 279010001551 Uncharacterized conserved protein [Function unknown]; Region: COG2128 279010001552 Helix-turn-helix domains; Region: HTH; cl00088 279010001553 DNA topoisomerase III; Provisional; Region: PRK07726 279010001554 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 279010001555 active site 279010001556 putative interdomain interaction site [polypeptide binding]; other site 279010001557 putative metal-binding site [ion binding]; other site 279010001558 putative nucleotide binding site [chemical binding]; other site 279010001559 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279010001560 domain I; other site 279010001561 DNA binding groove [nucleotide binding] 279010001562 phosphate binding site [ion binding]; other site 279010001563 domain II; other site 279010001564 domain III; other site 279010001565 nucleotide binding site [chemical binding]; other site 279010001566 catalytic site [active] 279010001567 domain IV; other site 279010001568 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 279010001569 Amino acid permease; Region: AA_permease_2; pfam13520 279010001570 pyruvate oxidase; Provisional; Region: PRK08611 279010001571 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 279010001572 PYR/PP interface [polypeptide binding]; other site 279010001573 tetramer interface [polypeptide binding]; other site 279010001574 dimer interface [polypeptide binding]; other site 279010001575 TPP binding site [chemical binding]; other site 279010001576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 279010001577 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 279010001578 TPP-binding site [chemical binding]; other site 279010001579 Chitin binding domain; Region: Chitin_bind_3; cl03871 279010001580 Helix-turn-helix domains; Region: HTH; cl00088 279010001581 putative transposase OrfB; Reviewed; Region: PHA02517 279010001582 Integrase core domain; Region: rve; cl01316 279010001583 Helix-turn-helix domains; Region: HTH; cl00088 279010001584 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010001585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010001586 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 279010001587 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 279010001588 aspartate ammonia-lyase; Provisional; Region: PRK14515 279010001589 Aspartase; Region: Aspartase; cd01357 279010001590 active sites [active] 279010001591 tetramer interface [polypeptide binding]; other site 279010001592 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010001593 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010001594 active site 279010001595 TDP-binding site; other site 279010001596 acceptor substrate-binding pocket; other site 279010001597 homodimer interface [polypeptide binding]; other site 279010001598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 279010001599 EcsC protein family; Region: EcsC; pfam12787 279010001600 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 279010001601 Cupin domain; Region: Cupin_2; cl09118 279010001602 General stress protein [General function prediction only]; Region: GsiB; COG3729 279010001603 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010001604 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010001605 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010001606 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010001607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010001608 Walker A/P-loop; other site 279010001609 ATP binding site [chemical binding]; other site 279010001610 Q-loop/lid; other site 279010001611 ABC transporter signature motif; other site 279010001612 Walker B; other site 279010001613 D-loop; other site 279010001614 H-loop/switch region; other site 279010001615 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010001616 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010001617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 279010001618 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 279010001619 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 279010001620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010001621 catalytic residues [active] 279010001622 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 279010001623 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 279010001624 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010001625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010001626 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 279010001627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010001628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010001629 Esterase/lipase [General function prediction only]; Region: COG1647 279010001630 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 279010001631 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010001632 ATP binding site [chemical binding]; other site 279010001633 Mg++ binding site [ion binding]; other site 279010001634 motif III; other site 279010001635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010001636 nucleotide binding region [chemical binding]; other site 279010001637 ATP-binding site [chemical binding]; other site 279010001638 Bacterial PH domain; Region: DUF304; cl01348 279010001639 Predicted membrane protein [Function unknown]; Region: COG3428 279010001640 Bacterial PH domain; Region: DUF304; cl01348 279010001641 Bacterial PH domain; Region: DUF304; cl01348 279010001642 Bacterial PH domain; Region: DUF304; cl01348 279010001643 Rhomboid family; Region: Rhomboid; cl11446 279010001644 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 279010001645 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 279010001646 alanine racemase; Region: alr; TIGR00492 279010001647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 279010001648 active site 279010001649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010001650 dimer interface [polypeptide binding]; other site 279010001651 substrate binding site [chemical binding]; other site 279010001652 catalytic residues [active] 279010001653 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 279010001654 PemK-like protein; Region: PemK; cl00995 279010001655 Rsbr N terminal; Region: Rsbr_N; pfam08678 279010001656 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010001657 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010001658 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010001659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001660 ATP binding site [chemical binding]; other site 279010001661 Mg2+ binding site [ion binding]; other site 279010001662 G-X-G motif; other site 279010001663 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 279010001664 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 279010001665 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 279010001666 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 279010001667 anti sigma factor interaction site; other site 279010001668 regulatory phosphorylation site [posttranslational modification]; other site 279010001669 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010001670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001671 ATP binding site [chemical binding]; other site 279010001672 Mg2+ binding site [ion binding]; other site 279010001673 G-X-G motif; other site 279010001674 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 279010001675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010001676 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010001677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010001678 DNA binding residues [nucleotide binding] 279010001679 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 279010001680 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 279010001681 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 279010001682 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 279010001683 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 279010001684 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 279010001685 RNA binding site [nucleotide binding]; other site 279010001686 Helix-turn-helix domains; Region: HTH; cl00088 279010001687 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279010001688 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 279010001689 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010001690 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 279010001691 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 279010001692 SprT homologues; Region: SprT; cl01182 279010001693 EamA-like transporter family; Region: EamA; cl01037 279010001694 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010001695 EamA-like transporter family; Region: EamA; cl01037 279010001696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010001697 non-specific DNA binding site [nucleotide binding]; other site 279010001698 salt bridge; other site 279010001699 sequence-specific DNA binding site [nucleotide binding]; other site 279010001700 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 279010001701 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 279010001702 putative di-iron ligands [ion binding]; other site 279010001703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 279010001704 DNA-binding site [nucleotide binding]; DNA binding site 279010001705 RNA-binding motif; other site 279010001706 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 279010001707 NADP binding site [chemical binding]; other site 279010001708 dimer interface [polypeptide binding]; other site 279010001709 Predicted membrane protein [Function unknown]; Region: COG2364 279010001710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010001711 Helix-turn-helix domains; Region: HTH; cl00088 279010001712 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010001713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001714 Coenzyme A binding pocket [chemical binding]; other site 279010001715 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 279010001716 Arginase family; Region: Arginase; cl00306 279010001717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010001718 dimerization interface [polypeptide binding]; other site 279010001719 putative DNA binding site [nucleotide binding]; other site 279010001720 putative Zn2+ binding site [ion binding]; other site 279010001721 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010001722 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001723 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010001724 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010001725 LysE type translocator; Region: LysE; cl00565 279010001726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010001727 Helix-turn-helix domains; Region: HTH; cl00088 279010001728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010001729 dimerization interface [polypeptide binding]; other site 279010001730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001731 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010001732 putative substrate translocation pore; other site 279010001733 Putative cyclase; Region: Cyclase; cl00814 279010001734 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279010001735 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 279010001736 Yip1 domain; Region: Yip1; cl12048 279010001737 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010001738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010001739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010001740 DNA binding residues [nucleotide binding] 279010001741 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001742 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010001743 OpgC protein; Region: OpgC_C; cl00792 279010001744 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010001745 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 279010001746 catalytic triad [active] 279010001747 catalytic triad [active] 279010001748 oxyanion hole [active] 279010001749 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 279010001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001751 putative substrate translocation pore; other site 279010001752 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 279010001753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010001754 dimer interface [polypeptide binding]; other site 279010001755 phosphorylation site [posttranslational modification] 279010001756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001757 ATP binding site [chemical binding]; other site 279010001758 Mg2+ binding site [ion binding]; other site 279010001759 G-X-G motif; other site 279010001760 Response regulator receiver domain; Region: Response_reg; pfam00072 279010001761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001762 active site 279010001763 phosphorylation site [posttranslational modification] 279010001764 intermolecular recognition site; other site 279010001765 dimerization interface [polypeptide binding]; other site 279010001766 Histidine kinase; Region: His_kinase; pfam06580 279010001767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010001768 ATP binding site [chemical binding]; other site 279010001769 Mg2+ binding site [ion binding]; other site 279010001770 G-X-G motif; other site 279010001771 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 279010001772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010001773 active site 279010001774 phosphorylation site [posttranslational modification] 279010001775 intermolecular recognition site; other site 279010001776 dimerization interface [polypeptide binding]; other site 279010001777 Helix-turn-helix domains; Region: HTH; cl00088 279010001778 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001779 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001780 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001781 Collagen binding domain; Region: Collagen_bind; pfam05737 279010001782 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001783 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001784 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001785 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001786 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001787 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001788 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001789 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010001790 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 279010001791 active site 279010001792 catalytic site [active] 279010001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001794 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010001795 putative substrate translocation pore; other site 279010001796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001797 thiamine monophosphate kinase; Provisional; Region: PRK05731 279010001798 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 279010001799 ATP binding site [chemical binding]; other site 279010001800 dimerization interface [polypeptide binding]; other site 279010001801 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 279010001802 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 279010001803 Glycoprotease family; Region: Peptidase_M22; pfam00814 279010001804 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 279010001805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010001806 Coenzyme A binding pocket [chemical binding]; other site 279010001807 UGMP family protein; Validated; Region: PRK09604 279010001808 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 279010001809 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010001810 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010001811 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010001812 ABC transporter; Region: ABC_tran_2; pfam12848 279010001813 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010001814 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 279010001815 trimer interface [polypeptide binding]; other site 279010001816 dimer interface [polypeptide binding]; other site 279010001817 putative active site [active] 279010001818 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 279010001819 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 279010001820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010001821 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 279010001822 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 279010001823 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 279010001824 CAAX protease self-immunity; Region: Abi; cl00558 279010001825 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 279010001826 oligomerisation interface [polypeptide binding]; other site 279010001827 mobile loop; other site 279010001828 roof hairpin; other site 279010001829 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 279010001830 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 279010001831 ring oligomerisation interface [polypeptide binding]; other site 279010001832 ATP/Mg binding site [chemical binding]; other site 279010001833 stacking interactions; other site 279010001834 hinge regions; other site 279010001835 YolD-like protein; Region: YolD; pfam08863 279010001836 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 279010001837 VanW like protein; Region: VanW; pfam04294 279010001838 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 279010001839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010001840 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 279010001841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010001842 Helix-turn-helix domains; Region: HTH; cl00088 279010001843 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010001844 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010001845 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 279010001846 Protein of unknown function, DUF488; Region: DUF488; cl01246 279010001847 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 279010001848 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 279010001849 putative NAD(P) binding site [chemical binding]; other site 279010001850 active site 279010001851 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 279010001852 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 279010001853 substrate binding pocket [chemical binding]; other site 279010001854 catalytic triad [active] 279010001855 D-galactonate transporter; Region: 2A0114; TIGR00893 279010001856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010001857 putative substrate translocation pore; other site 279010001858 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 279010001859 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 279010001860 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 279010001861 Repair protein; Region: Repair_PSII; cl01535 279010001862 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 279010001863 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 279010001864 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 279010001865 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 279010001866 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279010001867 Predicted transcriptional regulators [Transcription]; Region: COG1378 279010001868 Helix-turn-helix domains; Region: HTH; cl00088 279010001869 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 279010001870 C-terminal domain interface [polypeptide binding]; other site 279010001871 sugar binding site [chemical binding]; other site 279010001872 LysE type translocator; Region: LysE; cl00565 279010001873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010001874 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 279010001875 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010001876 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010001877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010001878 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 279010001879 dimer interface [polypeptide binding]; other site 279010001880 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010001881 Helix-turn-helix domains; Region: HTH; cl00088 279010001882 WYL domain; Region: WYL; cl14852 279010001883 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001884 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010001885 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010001886 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 279010001887 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 279010001888 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 279010001889 active site 279010001890 Na/Ca binding site [ion binding]; other site 279010001891 catalytic site [active] 279010001892 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 279010001893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010001894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010001895 DNA binding site [nucleotide binding] 279010001896 domain linker motif; other site 279010001897 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010001898 ligand binding site [chemical binding]; other site 279010001899 dimerization interface [polypeptide binding]; other site 279010001900 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 279010001901 homodimer interface [polypeptide binding]; other site 279010001902 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 279010001903 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 279010001904 active site 279010001905 homodimer interface [polypeptide binding]; other site 279010001906 catalytic site [active] 279010001907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010001908 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 279010001909 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010001910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001911 dimer interface [polypeptide binding]; other site 279010001912 conserved gate region; other site 279010001913 putative PBP binding loops; other site 279010001914 ABC-ATPase subunit interface; other site 279010001915 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 279010001916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010001917 dimer interface [polypeptide binding]; other site 279010001918 conserved gate region; other site 279010001919 putative PBP binding loops; other site 279010001920 ABC-ATPase subunit interface; other site 279010001921 Predicted integral membrane protein [Function unknown]; Region: COG5521 279010001922 maltose phosphorylase; Provisional; Region: PRK13807 279010001923 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 279010001924 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 279010001925 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 279010001926 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010001927 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010001928 Ca binding site [ion binding]; other site 279010001929 active site 279010001930 catalytic site [active] 279010001931 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 279010001932 beta-phosphoglucomutase; Region: bPGM; TIGR01990 279010001933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010001934 motif II; other site 279010001935 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 279010001936 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 279010001937 active site 279010001938 HIGH motif; other site 279010001939 dimer interface [polypeptide binding]; other site 279010001940 KMSKS motif; other site 279010001941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 279010001942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010001943 Helix-turn-helix domains; Region: HTH; cl00088 279010001944 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 279010001945 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 279010001946 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 279010001947 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 279010001948 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279010001949 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 279010001950 Catalytic site [active] 279010001951 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 279010001952 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010001953 NAD(P) binding site [chemical binding]; other site 279010001954 putative active site [active] 279010001955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010001956 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010001957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010001958 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010001959 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 279010001960 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 279010001961 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 279010001962 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 279010001963 OpgC protein; Region: OpgC_C; cl00792 279010001964 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010001965 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279010001966 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279010001967 Cation efflux family; Region: Cation_efflux; cl00316 279010001968 MoxR-like ATPases [General function prediction only]; Region: COG0714 279010001969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010001970 Walker A motif; other site 279010001971 ATP binding site [chemical binding]; other site 279010001972 Walker B motif; other site 279010001973 arginine finger; other site 279010001974 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 279010001975 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010001976 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 279010001977 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 279010001978 GMP synthase; Reviewed; Region: guaA; PRK00074 279010001979 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 279010001980 AMP/PPi binding site [chemical binding]; other site 279010001981 candidate oxyanion hole; other site 279010001982 catalytic triad [active] 279010001983 potential glutamine specificity residues [chemical binding]; other site 279010001984 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 279010001985 ATP Binding subdomain [chemical binding]; other site 279010001986 Ligand Binding sites [chemical binding]; other site 279010001987 Dimerization subdomain; other site 279010001988 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 279010001989 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010001990 NETI protein; Region: NETI; pfam14044 279010001991 AIR carboxylase; Region: AIRC; cl00310 279010001992 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 279010001993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010001994 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010001995 adenylosuccinate lyase; Provisional; Region: PRK07492 279010001996 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 279010001997 tetramer interface [polypeptide binding]; other site 279010001998 active site 279010001999 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 279010002000 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 279010002001 ATP binding site [chemical binding]; other site 279010002002 active site 279010002003 substrate binding site [chemical binding]; other site 279010002004 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 279010002005 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 279010002006 putative active site [active] 279010002007 catalytic triad [active] 279010002008 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 279010002009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 279010002010 dimerization interface [polypeptide binding]; other site 279010002011 ATP binding site [chemical binding]; other site 279010002012 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 279010002013 dimerization interface [polypeptide binding]; other site 279010002014 ATP binding site [chemical binding]; other site 279010002015 amidophosphoribosyltransferase; Provisional; Region: PRK07631 279010002016 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 279010002017 active site 279010002018 tetramer interface [polypeptide binding]; other site 279010002019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010002020 active site 279010002021 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 279010002022 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 279010002023 dimerization interface [polypeptide binding]; other site 279010002024 putative ATP binding site [chemical binding]; other site 279010002025 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 279010002026 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 279010002027 active site 279010002028 substrate binding site [chemical binding]; other site 279010002029 cosubstrate binding site; other site 279010002030 catalytic site [active] 279010002031 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 279010002032 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 279010002033 purine monophosphate binding site [chemical binding]; other site 279010002034 dimer interface [polypeptide binding]; other site 279010002035 putative catalytic residues [active] 279010002036 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 279010002037 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 279010002038 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 279010002039 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 279010002040 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010002041 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 279010002042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002043 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010002044 ANTAR domain; Region: ANTAR; cl04297 279010002045 Transposase domain (DUF772); Region: DUF772; cl15789 279010002046 Transposase domain (DUF772); Region: DUF772; cl15789 279010002047 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 279010002048 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 279010002049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010002050 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 279010002051 active site 279010002052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010002053 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 279010002054 Helix-turn-helix domains; Region: HTH; cl00088 279010002055 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 279010002056 substrate binding site [chemical binding]; other site 279010002057 putative active site [active] 279010002058 dimer interface [polypeptide binding]; other site 279010002059 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 279010002060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002061 Family description; Region: UvrD_C_2; cl15862 279010002062 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 279010002063 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 279010002064 nucleotide binding pocket [chemical binding]; other site 279010002065 K-X-D-G motif; other site 279010002066 catalytic site [active] 279010002067 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 279010002068 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 279010002069 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 279010002070 Dimer interface [polypeptide binding]; other site 279010002071 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 279010002072 Helix-turn-helix domains; Region: HTH; cl00088 279010002073 DNA-binding site [nucleotide binding]; DNA binding site 279010002074 PRD domain; Region: PRD; cl15445 279010002075 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 279010002076 Protein of unknown function; Region: YhfT; pfam10797 279010002077 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 279010002078 active site 279010002079 substrate binding pocket [chemical binding]; other site 279010002080 homodimer interaction site [polypeptide binding]; other site 279010002081 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010002082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010002083 putative mutase; Provisional; Region: PRK12383 279010002084 Sulfatase; Region: Sulfatase; cl10460 279010002085 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 279010002086 dimer interface [polypeptide binding]; other site 279010002087 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 279010002088 active site 279010002089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010002090 substrate binding site [chemical binding]; other site 279010002091 catalytic residue [active] 279010002092 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 279010002093 active site 279010002094 trimer interface [polypeptide binding]; other site 279010002095 allosteric site; other site 279010002096 active site lid [active] 279010002097 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010002098 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 279010002099 MgtC family; Region: MgtC; pfam02308 279010002100 Sodium:solute symporter family; Region: SSF; cl00456 279010002101 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010002102 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 279010002103 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 279010002104 Amidase; Region: Amidase; cl11426 279010002105 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 279010002106 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 279010002107 GatB domain; Region: GatB_Yqey; cl11497 279010002108 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 279010002109 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 279010002110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002111 Helix-turn-helix domains; Region: HTH; cl00088 279010002112 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 279010002113 Protein export membrane protein; Region: SecD_SecF; cl14618 279010002114 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010002115 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010002116 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 279010002117 active site 279010002118 dimerization interface [polypeptide binding]; other site 279010002119 putative lipid kinase; Reviewed; Region: PRK13337 279010002120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 279010002121 TRAM domain; Region: TRAM; cl01282 279010002122 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 279010002123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002124 S-adenosylmethionine binding site [chemical binding]; other site 279010002125 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002126 HsdM N-terminal domain; Region: HsdM_N; pfam12161 279010002127 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 279010002128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002129 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002130 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279010002131 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010002132 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 279010002133 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 279010002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010002135 ATP binding site [chemical binding]; other site 279010002136 putative Mg++ binding site [ion binding]; other site 279010002137 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 279010002138 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 279010002139 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010002140 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002141 active site turn [active] 279010002142 phosphorylation site [posttranslational modification] 279010002143 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010002144 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 279010002145 HPr interaction site; other site 279010002146 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010002147 active site 279010002148 phosphorylation site [posttranslational modification] 279010002149 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010002150 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010002151 CAT RNA binding domain; Region: CAT_RBD; cl03904 279010002152 PRD domain; Region: PRD; cl15445 279010002153 PRD domain; Region: PRD; cl15445 279010002154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002155 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 279010002156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002157 Transcriptional regulator; Region: Transcrip_reg; cl00361 279010002158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002159 non-specific DNA binding site [nucleotide binding]; other site 279010002160 salt bridge; other site 279010002161 sequence-specific DNA binding site [nucleotide binding]; other site 279010002162 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 279010002163 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010002164 NAD(P) binding site [chemical binding]; other site 279010002165 catalytic residues [active] 279010002166 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010002167 dimer interface [polypeptide binding]; other site 279010002168 putative CheW interface [polypeptide binding]; other site 279010002169 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010002170 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 279010002171 transmembrane helices; other site 279010002172 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002173 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002174 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002175 ABC transporter; Region: ABC_tran_2; pfam12848 279010002176 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002177 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 279010002178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 279010002179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 279010002180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010002181 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 279010002182 Nucleoside recognition; Region: Gate; cl00486 279010002183 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010002184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002185 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 279010002186 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 279010002187 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 279010002188 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 279010002189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010002190 inhibitor-cofactor binding pocket; inhibition site 279010002191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002192 catalytic residue [active] 279010002193 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 279010002194 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 279010002195 substrate-cofactor binding pocket; other site 279010002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002197 catalytic residue [active] 279010002198 AAA domain; Region: AAA_26; pfam13500 279010002199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002201 biotin synthase; Validated; Region: PRK06256 279010002202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010002203 FeS/SAM binding site; other site 279010002204 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 279010002205 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010002206 Ion transport protein; Region: Ion_trans; pfam00520 279010002207 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 279010002208 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010002209 DNA binding residues [nucleotide binding] 279010002210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002212 putative substrate translocation pore; other site 279010002213 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002214 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002215 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002216 ABC transporter; Region: ABC_tran_2; pfam12848 279010002217 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002218 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010002219 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010002220 ATP binding site [chemical binding]; other site 279010002221 Mg++ binding site [ion binding]; other site 279010002222 motif III; other site 279010002223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010002224 nucleotide binding region [chemical binding]; other site 279010002225 ATP-binding site [chemical binding]; other site 279010002226 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 279010002227 Prostaglandin dehydrogenases; Region: PGDH; cd05288 279010002228 NAD(P) binding site [chemical binding]; other site 279010002229 substrate binding site [chemical binding]; other site 279010002230 dimer interface [polypeptide binding]; other site 279010002231 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 279010002232 Heat induced stress protein YflT; Region: YflT; pfam11181 279010002233 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279010002234 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 279010002235 transmembrane helices; other site 279010002236 VanZ like family; Region: VanZ; cl01971 279010002237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010002238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010002239 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_5; cd06242 279010002240 putative active site [active] 279010002241 Zn binding site [ion binding]; other site 279010002242 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 279010002243 active site 279010002244 dimer interface [polypeptide binding]; other site 279010002245 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 279010002246 SdpI/YhfL protein family; Region: SdpI; pfam13630 279010002247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010002248 dimerization interface [polypeptide binding]; other site 279010002249 putative DNA binding site [nucleotide binding]; other site 279010002250 putative Zn2+ binding site [ion binding]; other site 279010002251 Acylphosphatase; Region: Acylphosphatase; cl00551 279010002252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 279010002253 MOSC domain; Region: MOSC; pfam03473 279010002254 3-alpha domain; Region: 3-alpha; pfam03475 279010002255 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 279010002256 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 279010002257 active site 279010002258 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010002259 Sulfatase; Region: Sulfatase; cl10460 279010002260 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 279010002261 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010002262 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010002263 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 279010002264 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002265 active site turn [active] 279010002266 phosphorylation site [posttranslational modification] 279010002267 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010002268 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010002269 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010002270 Ca binding site [ion binding]; other site 279010002271 active site 279010002272 catalytic site [active] 279010002273 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 279010002274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010002275 DNA-binding site [nucleotide binding]; DNA binding site 279010002276 UTRA domain; Region: UTRA; cl01230 279010002277 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 279010002278 putative trimer interface [polypeptide binding]; other site 279010002279 putative CoA binding site [chemical binding]; other site 279010002280 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 279010002281 putative trimer interface [polypeptide binding]; other site 279010002282 putative active site [active] 279010002283 putative substrate binding site [chemical binding]; other site 279010002284 putative CoA binding site [chemical binding]; other site 279010002285 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 279010002286 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010002287 inhibitor-cofactor binding pocket; inhibition site 279010002288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002289 catalytic residue [active] 279010002290 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 279010002291 putative trimer interface [polypeptide binding]; other site 279010002292 putative CoA binding site [chemical binding]; other site 279010002293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279010002294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002295 NAD(P) binding site [chemical binding]; other site 279010002296 active site 279010002297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010002298 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010002299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010002300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010002301 active site 279010002302 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 279010002303 putative metal binding site; other site 279010002304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010002305 binding surface 279010002306 TPR motif; other site 279010002307 TPR repeat; Region: TPR_11; pfam13414 279010002308 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 279010002309 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010002310 inhibitor-cofactor binding pocket; inhibition site 279010002311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002312 catalytic residue [active] 279010002313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002315 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010002316 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 279010002317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002318 NAD(P) binding site [chemical binding]; other site 279010002319 active site 279010002320 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 279010002321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002322 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 279010002323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010002324 Helix-turn-helix domains; Region: HTH; cl00088 279010002325 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 279010002326 FMN binding site [chemical binding]; other site 279010002327 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 279010002328 dimer interface [polypeptide binding]; other site 279010002329 FMN binding site [chemical binding]; other site 279010002330 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 279010002331 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 279010002332 active site 279010002333 metal binding site [ion binding]; metal-binding site 279010002334 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002335 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279010002336 active site 279010002337 metal binding site [ion binding]; metal-binding site 279010002338 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002339 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010002340 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 279010002341 proposed catalytic triad [active] 279010002342 conserved cys residue [active] 279010002343 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 279010002344 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010002345 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010002346 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010002347 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 279010002348 active site 279010002349 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 279010002350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010002352 putative substrate translocation pore; other site 279010002353 OsmC-like protein; Region: OsmC; cl00767 279010002354 calcium/proton exchanger (cax); Region: cax; TIGR00378 279010002355 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 279010002356 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 279010002357 YfkD-like protein; Region: YfkD; pfam14167 279010002358 Radical SAM superfamily; Region: Radical_SAM; pfam04055 279010002359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010002360 FeS/SAM binding site; other site 279010002361 YfkB-like domain; Region: YfkB; pfam08756 279010002362 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 279010002363 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 279010002364 NodB motif; other site 279010002365 active site 279010002366 catalytic site [active] 279010002367 Cd binding site [ion binding]; other site 279010002368 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 279010002369 dimer interface [polypeptide binding]; other site 279010002370 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010002371 active site 279010002372 metal binding site [ion binding]; metal-binding site 279010002373 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 279010002374 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 279010002375 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 279010002376 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010002377 minor groove reading motif; other site 279010002378 helix-hairpin-helix signature motif; other site 279010002379 substrate binding pocket [chemical binding]; other site 279010002380 active site 279010002381 TRAM domain; Region: TRAM; cl01282 279010002382 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 279010002383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002384 S-adenosylmethionine binding site [chemical binding]; other site 279010002385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002386 Helix-turn-helix domains; Region: HTH; cl00088 279010002387 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010002388 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010002389 active site 279010002390 TDP-binding site; other site 279010002391 acceptor substrate-binding pocket; other site 279010002392 homodimer interface [polypeptide binding]; other site 279010002393 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 279010002394 benzoate transport; Region: 2A0115; TIGR00895 279010002395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002396 putative substrate translocation pore; other site 279010002397 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 279010002398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002399 active site turn [active] 279010002400 phosphorylation site [posttranslational modification] 279010002401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010002402 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010002403 CAT RNA binding domain; Region: CAT_RBD; cl03904 279010002404 PRD domain; Region: PRD; cl15445 279010002405 PRD domain; Region: PRD; cl15445 279010002406 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 279010002407 active site clefts [active] 279010002408 zinc binding site [ion binding]; other site 279010002409 dimer interface [polypeptide binding]; other site 279010002410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 279010002411 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 279010002412 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 279010002413 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 279010002414 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 279010002415 DJ-1 family protein; Region: not_thiJ; TIGR01383 279010002416 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 279010002417 conserved cys residue [active] 279010002418 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 279010002419 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010002420 tetramer interface [polypeptide binding]; other site 279010002421 TPP-binding site [chemical binding]; other site 279010002422 heterodimer interface [polypeptide binding]; other site 279010002423 phosphorylation loop region [posttranslational modification] 279010002424 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010002425 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010002426 alpha subunit interface [polypeptide binding]; other site 279010002427 TPP binding site [chemical binding]; other site 279010002428 heterodimer interface [polypeptide binding]; other site 279010002429 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010002430 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010002431 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010002432 E3 interaction surface; other site 279010002433 lipoyl attachment site [posttranslational modification]; other site 279010002434 e3 binding domain; Region: E3_binding; pfam02817 279010002435 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 279010002436 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 279010002437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010002438 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010002439 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 279010002440 GAF domain; Region: GAF; cl15785 279010002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010002442 Walker A motif; other site 279010002443 ATP binding site [chemical binding]; other site 279010002444 Walker B motif; other site 279010002445 arginine finger; other site 279010002446 Helix-turn-helix domains; Region: HTH; cl00088 279010002447 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 279010002448 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010002449 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 279010002450 NAD binding site [chemical binding]; other site 279010002451 sugar binding site [chemical binding]; other site 279010002452 divalent metal binding site [ion binding]; other site 279010002453 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010002454 dimer interface [polypeptide binding]; other site 279010002455 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010002456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010002457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010002458 putative active site [active] 279010002459 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 279010002460 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010002461 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010002462 active site turn [active] 279010002463 phosphorylation site [posttranslational modification] 279010002464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010002465 S-adenosylmethionine binding site [chemical binding]; other site 279010002466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 279010002467 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010002468 Helix-turn-helix domains; Region: HTH; cl00088 279010002469 DoxX; Region: DoxX; cl00976 279010002470 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 279010002471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 279010002472 putative metal binding site [ion binding]; other site 279010002473 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010002474 active site 279010002475 metal binding site [ion binding]; metal-binding site 279010002476 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 279010002477 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 279010002478 active site 279010002479 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 279010002480 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 279010002481 inhibitor binding site; inhibition site 279010002482 active site 279010002483 Cupin domain; Region: Cupin_2; cl09118 279010002484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010002485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010002486 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 279010002487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010002488 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010002489 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 279010002490 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 279010002491 nudix motif; other site 279010002492 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010002493 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010002494 Predicted integral membrane protein [Function unknown]; Region: COG0392 279010002495 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 279010002496 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 279010002497 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 279010002498 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 279010002499 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 279010002500 putative FMN binding site [chemical binding]; other site 279010002501 YfhD-like protein; Region: YfhD; pfam14151 279010002502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010002503 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 279010002504 TIGR01777 family protein; Region: yfcH 279010002505 putative NAD(P) binding site [chemical binding]; other site 279010002506 putative active site [active] 279010002507 RecX family; Region: RecX; cl00936 279010002508 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 279010002509 Small acid-soluble spore protein K family; Region: SspK; cl11509 279010002510 WVELL protein; Region: WVELL; pfam14043 279010002511 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 279010002512 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010002513 Ligand binding site; other site 279010002514 Putative Catalytic site; other site 279010002515 DXD motif; other site 279010002516 GtrA-like protein; Region: GtrA; cl00971 279010002517 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 279010002518 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 279010002519 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 279010002520 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010002521 minor groove reading motif; other site 279010002522 helix-hairpin-helix signature motif; other site 279010002523 substrate binding pocket [chemical binding]; other site 279010002524 active site 279010002525 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 279010002526 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 279010002527 DNA binding and oxoG recognition site [nucleotide binding] 279010002528 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 279010002529 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 279010002530 putative NAD(P) binding site [chemical binding]; other site 279010002531 active site 279010002532 YgaB-like protein; Region: YgaB; pfam14182 279010002533 Protein of unknown function (DUF402); Region: DUF402; cl00979 279010002534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010002535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010002536 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 279010002537 Walker A/P-loop; other site 279010002538 ATP binding site [chemical binding]; other site 279010002539 Q-loop/lid; other site 279010002540 ABC transporter signature motif; other site 279010002541 Walker B; other site 279010002542 D-loop; other site 279010002543 H-loop/switch region; other site 279010002544 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010002545 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010002546 Walker A/P-loop; other site 279010002547 ATP binding site [chemical binding]; other site 279010002548 Q-loop/lid; other site 279010002549 ABC transporter signature motif; other site 279010002550 Walker B; other site 279010002551 D-loop; other site 279010002552 H-loop/switch region; other site 279010002553 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010002554 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 279010002555 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010002556 Walker A/P-loop; other site 279010002557 ATP binding site [chemical binding]; other site 279010002558 Q-loop/lid; other site 279010002559 ABC transporter signature motif; other site 279010002560 Walker B; other site 279010002561 D-loop; other site 279010002562 H-loop/switch region; other site 279010002563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010002564 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 279010002565 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 279010002566 peptide binding site [polypeptide binding]; other site 279010002567 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010002568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002569 dimer interface [polypeptide binding]; other site 279010002570 conserved gate region; other site 279010002571 putative PBP binding loops; other site 279010002572 ABC-ATPase subunit interface; other site 279010002573 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002575 dimer interface [polypeptide binding]; other site 279010002576 conserved gate region; other site 279010002577 putative PBP binding loops; other site 279010002578 ABC-ATPase subunit interface; other site 279010002579 Predicted membrane protein [Function unknown]; Region: COG4129 279010002580 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 279010002581 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 279010002582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010002583 inhibitor-cofactor binding pocket; inhibition site 279010002584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002585 catalytic residue [active] 279010002586 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 279010002587 catalytic triad [active] 279010002588 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010002589 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010002590 metal binding site 2 [ion binding]; metal-binding site 279010002591 putative DNA binding helix; other site 279010002592 metal binding site 1 [ion binding]; metal-binding site 279010002593 dimer interface [polypeptide binding]; other site 279010002594 structural Zn2+ binding site [ion binding]; other site 279010002595 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 279010002596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002597 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010002598 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010002599 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010002600 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010002601 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010002602 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010002603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279010002606 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010002607 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 279010002608 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 279010002609 active site 279010002610 catalytic residue [active] 279010002611 dimer interface [polypeptide binding]; other site 279010002612 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 279010002613 ThiC-associated domain; Region: ThiC-associated; pfam13667 279010002614 ThiC family; Region: ThiC; cl08031 279010002615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 279010002616 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 279010002617 Walker A/P-loop; other site 279010002618 ATP binding site [chemical binding]; other site 279010002619 Q-loop/lid; other site 279010002620 ABC transporter signature motif; other site 279010002621 Walker B; other site 279010002622 D-loop; other site 279010002623 H-loop/switch region; other site 279010002624 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 279010002625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010002626 substrate binding pocket [chemical binding]; other site 279010002627 membrane-bound complex binding site; other site 279010002628 hinge residues; other site 279010002629 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 279010002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 279010002631 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 279010002632 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 279010002633 active site 279010002634 dimer interface [polypeptide binding]; other site 279010002635 non-prolyl cis peptide bond; other site 279010002636 insertion regions; other site 279010002637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002638 non-specific DNA binding site [nucleotide binding]; other site 279010002639 salt bridge; other site 279010002640 sequence-specific DNA binding site [nucleotide binding]; other site 279010002641 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010002642 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010002643 Walker A/P-loop; other site 279010002644 ATP binding site [chemical binding]; other site 279010002645 Q-loop/lid; other site 279010002646 ABC transporter signature motif; other site 279010002647 Walker B; other site 279010002648 D-loop; other site 279010002649 H-loop/switch region; other site 279010002650 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 279010002651 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 279010002652 B3/4 domain; Region: B3_4; cl11458 279010002653 iron-sulfur cluster binding protein, putative; Region: TIGR00276 279010002654 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 279010002655 4Fe-4S binding domain; Region: Fer4; cl02805 279010002656 HEAT repeats; Region: HEAT_2; pfam13646 279010002657 NlpC/P60 family; Region: NLPC_P60; cl11438 279010002658 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 279010002659 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 279010002660 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 279010002661 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 279010002662 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 279010002663 similar to hypothetical protein; RBL05485 279010002664 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 279010002665 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 279010002666 Uncharacterized conserved protein [Function unknown]; Region: COG2718 279010002667 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010002668 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010002669 carboxyltransferase (CT) interaction site; other site 279010002670 biotinylation site [posttranslational modification]; other site 279010002671 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 279010002672 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010002673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002674 putative substrate translocation pore; other site 279010002675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010002676 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010002677 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010002678 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 279010002679 Walker A/P-loop; other site 279010002680 ATP binding site [chemical binding]; other site 279010002681 Q-loop/lid; other site 279010002682 ABC transporter signature motif; other site 279010002683 Walker B; other site 279010002684 D-loop; other site 279010002685 H-loop/switch region; other site 279010002686 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010002687 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010002688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 279010002689 DNA-binding site [nucleotide binding]; DNA binding site 279010002690 RNA-binding motif; other site 279010002691 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 279010002692 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 279010002693 Walker A/P-loop; other site 279010002694 ATP binding site [chemical binding]; other site 279010002695 Q-loop/lid; other site 279010002696 ABC transporter signature motif; other site 279010002697 Walker B; other site 279010002698 D-loop; other site 279010002699 H-loop/switch region; other site 279010002700 NIL domain; Region: NIL; cl09633 279010002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010002702 dimer interface [polypeptide binding]; other site 279010002703 conserved gate region; other site 279010002704 ABC-ATPase subunit interface; other site 279010002705 NMT1-like family; Region: NMT1_2; cl15260 279010002706 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010002707 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010002708 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 279010002709 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010002710 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 279010002711 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010002712 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 279010002713 Coat F domain; Region: Coat_F; cl15836 279010002714 PAS domain; Region: PAS_10; pfam13596 279010002715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010002716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010002717 putative active site [active] 279010002718 heme pocket [chemical binding]; other site 279010002719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010002720 dimer interface [polypeptide binding]; other site 279010002721 phosphorylation site [posttranslational modification] 279010002722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010002723 ATP binding site [chemical binding]; other site 279010002724 Mg2+ binding site [ion binding]; other site 279010002725 G-X-G motif; other site 279010002726 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG4085 279010002727 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 279010002728 generic binding surface II; other site 279010002729 generic binding surface I; other site 279010002730 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 279010002731 generic binding surface II; other site 279010002732 generic binding surface I; other site 279010002733 Staphylococcal nuclease homologues; Region: SNc; smart00318 279010002734 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 279010002735 Catalytic site; other site 279010002736 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279010002737 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 279010002738 putative active site [active] 279010002739 putative metal binding site [ion binding]; other site 279010002740 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010002741 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 279010002742 active site 279010002743 catalytic site [active] 279010002744 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 279010002745 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 279010002746 active site 279010002747 FOG: CBS domain [General function prediction only]; Region: COG0517 279010002748 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010002749 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 279010002750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010002751 motif II; other site 279010002752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010002753 Coenzyme A binding pocket [chemical binding]; other site 279010002754 Predicted amidohydrolase [General function prediction only]; Region: COG0388 279010002755 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 279010002756 putative active site [active] 279010002757 catalytic triad [active] 279010002758 putative dimer interface [polypeptide binding]; other site 279010002759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010002760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002761 Walker A/P-loop; other site 279010002762 ATP binding site [chemical binding]; other site 279010002763 Q-loop/lid; other site 279010002764 ABC transporter signature motif; other site 279010002765 Walker B; other site 279010002766 D-loop; other site 279010002767 H-loop/switch region; other site 279010002768 ABC transporter; Region: ABC_tran_2; pfam12848 279010002769 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010002770 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 279010002771 Membrane transport protein; Region: Mem_trans; cl09117 279010002772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002773 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 279010002774 NAD(P) binding site [chemical binding]; other site 279010002775 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 279010002776 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 279010002777 amphipathic channel; other site 279010002778 Asn-Pro-Ala signature motifs; other site 279010002779 glycerol kinase; Provisional; Region: glpK; PRK00047 279010002780 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 279010002781 N- and C-terminal domain interface [polypeptide binding]; other site 279010002782 active site 279010002783 MgATP binding site [chemical binding]; other site 279010002784 catalytic site [active] 279010002785 metal binding site [ion binding]; metal-binding site 279010002786 glycerol binding site [chemical binding]; other site 279010002787 homotetramer interface [polypeptide binding]; other site 279010002788 homodimer interface [polypeptide binding]; other site 279010002789 FBP binding site [chemical binding]; other site 279010002790 protein IIAGlc interface [polypeptide binding]; other site 279010002791 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 279010002792 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 279010002793 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 279010002794 active site 279010002795 substrate binding site [chemical binding]; other site 279010002796 metal binding site [ion binding]; metal-binding site 279010002797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010002798 non-specific DNA binding site [nucleotide binding]; other site 279010002799 salt bridge; other site 279010002800 sequence-specific DNA binding site [nucleotide binding]; other site 279010002801 GAF domain; Region: GAF; cl15785 279010002802 GAF domain; Region: GAF_2; pfam13185 279010002803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010002804 Histidine kinase; Region: HisKA_3; pfam07730 279010002805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010002806 ATP binding site [chemical binding]; other site 279010002807 Mg2+ binding site [ion binding]; other site 279010002808 G-X-G motif; other site 279010002809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010002810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010002811 active site 279010002812 phosphorylation site [posttranslational modification] 279010002813 intermolecular recognition site; other site 279010002814 dimerization interface [polypeptide binding]; other site 279010002815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010002816 DNA binding residues [nucleotide binding] 279010002817 dimerization interface [polypeptide binding]; other site 279010002818 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010002819 YhdB-like protein; Region: YhdB; pfam14148 279010002820 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 279010002821 Helix-turn-helix domains; Region: HTH; cl00088 279010002822 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010002823 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 279010002824 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 279010002825 heme-binding site [chemical binding]; other site 279010002826 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 279010002827 FAD binding pocket [chemical binding]; other site 279010002828 FAD binding motif [chemical binding]; other site 279010002829 phosphate binding motif [ion binding]; other site 279010002830 beta-alpha-beta structure motif; other site 279010002831 NAD binding pocket [chemical binding]; other site 279010002832 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 279010002833 SpoVR like protein; Region: SpoVR; pfam04293 279010002834 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010002835 putative peptidoglycan binding site; other site 279010002836 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010002837 putative peptidoglycan binding site; other site 279010002838 NlpC/P60 family; Region: NLPC_P60; cl11438 279010002839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010002840 Helix-turn-helix domains; Region: HTH; cl00088 279010002841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010002842 dimerization interface [polypeptide binding]; other site 279010002843 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 279010002844 dimer interface [polypeptide binding]; other site 279010002845 Citrate synthase; Region: Citrate_synt; pfam00285 279010002846 active site 279010002847 citrylCoA binding site [chemical binding]; other site 279010002848 oxalacetate/citrate binding site [chemical binding]; other site 279010002849 coenzyme A binding site [chemical binding]; other site 279010002850 catalytic triad [active] 279010002851 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 279010002852 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 279010002853 short chain dehydrogenase; Provisional; Region: PRK06701 279010002854 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010002855 NAD binding site [chemical binding]; other site 279010002856 metal binding site [ion binding]; metal-binding site 279010002857 active site 279010002858 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 279010002859 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010002860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010002861 catalytic residue [active] 279010002862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010002863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010002864 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010002865 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010002866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010002867 DNA-binding site [nucleotide binding]; DNA binding site 279010002868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010002869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002870 homodimer interface [polypeptide binding]; other site 279010002871 catalytic residue [active] 279010002872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010002873 Coenzyme A binding pocket [chemical binding]; other site 279010002874 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 279010002875 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 279010002876 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 279010002877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010002878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010002879 DNA binding residues [nucleotide binding] 279010002880 Cupin domain; Region: Cupin_2; cl09118 279010002881 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 279010002882 putative acyl-acceptor binding pocket; other site 279010002883 Protein of unknown function (DUF805); Region: DUF805; cl01224 279010002884 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 279010002885 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 279010002886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010002887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010002888 Helix-turn-helix domains; Region: HTH; cl00088 279010002889 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010002890 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010002891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010002892 Transporter associated domain; Region: CorC_HlyC; cl08393 279010002893 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 279010002894 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010002895 DNA binding residues [nucleotide binding] 279010002896 putative dimer interface [polypeptide binding]; other site 279010002897 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010002898 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010002899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010002900 Transporter associated domain; Region: CorC_HlyC; cl08393 279010002901 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010002902 active site 279010002903 metal binding site [ion binding]; metal-binding site 279010002904 CrcB-like protein; Region: CRCB; cl09114 279010002905 CrcB-like protein; Region: CRCB; cl09114 279010002906 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010002907 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010002908 active site 279010002909 catalytic site [active] 279010002910 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 279010002911 Mechanosensitive ion channel; Region: MS_channel; pfam00924 279010002912 NAD-dependent deacetylase; Provisional; Region: PRK00481 279010002913 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 279010002914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010002915 Coenzyme A binding pocket [chemical binding]; other site 279010002916 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 279010002917 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 279010002918 NodB motif; other site 279010002919 active site 279010002920 catalytic site [active] 279010002921 Zn binding site [ion binding]; other site 279010002922 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 279010002923 homodimer interface [polypeptide binding]; other site 279010002924 substrate-cofactor binding pocket; other site 279010002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010002926 catalytic residue [active] 279010002927 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 279010002928 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 279010002929 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 279010002930 active site 279010002931 catalytic residues [active] 279010002932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010002933 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 279010002934 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 279010002935 YcaO-like family; Region: YcaO; pfam02624 279010002936 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 279010002937 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 279010002938 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279010002939 Ligand Binding Site [chemical binding]; other site 279010002940 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 279010002941 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010002942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010002943 Walker A/P-loop; other site 279010002944 ATP binding site [chemical binding]; other site 279010002945 Q-loop/lid; other site 279010002946 ABC transporter signature motif; other site 279010002947 Walker B; other site 279010002948 D-loop; other site 279010002949 H-loop/switch region; other site 279010002950 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 279010002951 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010002952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010002953 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 279010002954 Walker A/P-loop; other site 279010002955 ATP binding site [chemical binding]; other site 279010002956 Q-loop/lid; other site 279010002957 ABC transporter signature motif; other site 279010002958 Walker B; other site 279010002959 D-loop; other site 279010002960 H-loop/switch region; other site 279010002961 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 279010002962 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010002963 NAD binding site [chemical binding]; other site 279010002964 substrate binding site [chemical binding]; other site 279010002965 putative active site [active] 279010002966 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010002967 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 279010002968 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 279010002969 Walker A/P-loop; other site 279010002970 ATP binding site [chemical binding]; other site 279010002971 Q-loop/lid; other site 279010002972 ABC transporter signature motif; other site 279010002973 Walker B; other site 279010002974 D-loop; other site 279010002975 H-loop/switch region; other site 279010002976 TOBE domain; Region: TOBE_2; cl01440 279010002977 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 279010002978 Helix-turn-helix domains; Region: HTH; cl00088 279010002979 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010002980 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010002981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 279010002982 Protein of unknown function (DUF964); Region: DUF964; cl01483 279010002983 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010002984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010002985 active site 279010002986 motif I; other site 279010002987 motif II; other site 279010002988 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010002989 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 279010002990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010002991 FeS/SAM binding site; other site 279010002992 enoyl-CoA hydratase; Provisional; Region: PRK07659 279010002993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010002994 substrate binding site [chemical binding]; other site 279010002995 oxyanion hole (OAH) forming residues; other site 279010002996 trimer interface [polypeptide binding]; other site 279010002997 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010002998 YhzD-like protein; Region: YhzD; pfam14120 279010002999 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 279010003000 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 279010003001 Walker A/P-loop; other site 279010003002 ATP binding site [chemical binding]; other site 279010003003 Q-loop/lid; other site 279010003004 ABC transporter signature motif; other site 279010003005 Walker B; other site 279010003006 D-loop; other site 279010003007 H-loop/switch region; other site 279010003008 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010003009 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 279010003010 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 279010003011 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279010003012 active site 279010003013 metal binding site [ion binding]; metal-binding site 279010003014 DNA binding site [nucleotide binding] 279010003015 Uncharacterized conserved protein [Function unknown]; Region: COG4717 279010003016 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 279010003017 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 279010003018 generic binding surface II; other site 279010003019 generic binding surface I; other site 279010003020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010003021 Zn2+ binding site [ion binding]; other site 279010003022 Mg2+ binding site [ion binding]; other site 279010003023 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 279010003024 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 279010003025 PPIC-type PPIASE domain; Region: Rotamase; cl08278 279010003026 similar to hypothetical protein; RBL05593 279010003027 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 279010003028 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 279010003029 transcriptional regulator Hpr; Provisional; Region: PRK13777 279010003030 Helix-turn-helix domains; Region: HTH; cl00088 279010003031 YtxH-like protein; Region: YtxH; cl02079 279010003032 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 279010003033 homodimer interface [polypeptide binding]; other site 279010003034 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279010003035 substrate-cofactor binding pocket; other site 279010003036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003037 catalytic residue [active] 279010003038 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 279010003039 HIT family signature motif; other site 279010003040 catalytic residue [active] 279010003041 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010003042 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010003043 Walker A/P-loop; other site 279010003044 ATP binding site [chemical binding]; other site 279010003045 Q-loop/lid; other site 279010003046 ABC transporter signature motif; other site 279010003047 Walker B; other site 279010003048 D-loop; other site 279010003049 H-loop/switch region; other site 279010003050 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 279010003051 EcsC protein family; Region: EcsC; pfam12787 279010003052 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010003053 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279010003054 metal binding site [ion binding]; metal-binding site 279010003055 dimer interface [polypeptide binding]; other site 279010003056 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 279010003057 Transglycosylase; Region: Transgly; cl07896 279010003058 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010003059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010003060 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 279010003061 substrate binding site [chemical binding]; other site 279010003062 active site 279010003063 ferrochelatase; Provisional; Region: PRK12435 279010003064 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 279010003065 C-terminal domain interface [polypeptide binding]; other site 279010003066 active site 279010003067 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 279010003068 active site 279010003069 N-terminal domain interface [polypeptide binding]; other site 279010003070 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 279010003071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010003073 Helix-turn-helix domains; Region: HTH; cl00088 279010003074 Predicted membrane protein [Function unknown]; Region: COG1511 279010003075 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010003076 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 279010003077 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 279010003078 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010003079 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 279010003080 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 279010003081 dimer interface [polypeptide binding]; other site 279010003082 active site 279010003083 CoA binding pocket [chemical binding]; other site 279010003084 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010003085 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 279010003086 putative oligomer interface [polypeptide binding]; other site 279010003087 putative active site [active] 279010003088 metal binding site [ion binding]; metal-binding site 279010003089 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010003090 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010003091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010003092 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 279010003093 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 279010003094 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 279010003095 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 279010003096 AMP-binding enzyme; Region: AMP-binding; cl15778 279010003097 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010003098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010003099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003100 non-specific DNA binding site [nucleotide binding]; other site 279010003101 salt bridge; other site 279010003102 sequence-specific DNA binding site [nucleotide binding]; other site 279010003103 Cupin domain; Region: Cupin_2; cl09118 279010003104 AzlC protein; Region: AzlC; cl00570 279010003105 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 279010003106 Peptidase family M48; Region: Peptidase_M48; cl12018 279010003107 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010003108 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010003109 active site 279010003110 catalytic residues [active] 279010003111 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010003112 EamA-like transporter family; Region: EamA; cl01037 279010003113 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 279010003114 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010003115 siderophore binding site; other site 279010003116 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010003117 ABC-ATPase subunit interface; other site 279010003118 dimer interface [polypeptide binding]; other site 279010003119 putative PBP binding regions; other site 279010003120 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010003121 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010003122 ABC-ATPase subunit interface; other site 279010003123 dimer interface [polypeptide binding]; other site 279010003124 putative PBP binding regions; other site 279010003125 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279010003126 catalytic core [active] 279010003127 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 279010003128 heme-binding site [chemical binding]; other site 279010003129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010003130 dimer interface [polypeptide binding]; other site 279010003131 putative CheW interface [polypeptide binding]; other site 279010003132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003133 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 279010003134 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 279010003135 [2Fe-2S] cluster binding site [ion binding]; other site 279010003136 short chain dehydrogenase; Provisional; Region: PRK06701 279010003137 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279010003138 NAD binding site [chemical binding]; other site 279010003139 metal binding site [ion binding]; metal-binding site 279010003140 active site 279010003141 IDEAL domain; Region: IDEAL; cl07452 279010003142 ComK protein; Region: ComK; cl11560 279010003143 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010003144 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010003145 Catalytic site [active] 279010003146 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010003147 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010003148 active site 279010003149 catalytic residues [active] 279010003150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010003152 putative substrate translocation pore; other site 279010003153 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 279010003154 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010003155 Helix-turn-helix domains; Region: HTH; cl00088 279010003156 allantoinase; Provisional; Region: PRK08044 279010003157 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 279010003158 active site 279010003159 allantoate amidohydrolase; Region: AllC; TIGR03176 279010003160 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 279010003161 active site 279010003162 metal binding site [ion binding]; metal-binding site 279010003163 dimer interface [polypeptide binding]; other site 279010003164 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 279010003165 Cupin domain; Region: Cupin_2; cl09118 279010003166 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 279010003167 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 279010003168 membrane protein FdrA; Validated; Region: PRK06091 279010003169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003170 CoA-ligase; Region: Ligase_CoA; cl02894 279010003171 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 279010003172 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 279010003173 carbamate kinase; Reviewed; Region: PRK12686 279010003174 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 279010003175 putative substrate binding site [chemical binding]; other site 279010003176 nucleotide binding site [chemical binding]; other site 279010003177 nucleotide binding site [chemical binding]; other site 279010003178 homodimer interface [polypeptide binding]; other site 279010003179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003180 D-galactonate transporter; Region: 2A0114; TIGR00893 279010003181 putative substrate translocation pore; other site 279010003182 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 279010003183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010003184 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010003185 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 279010003186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010003187 DNA binding site [nucleotide binding] 279010003188 domain linker motif; other site 279010003189 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 279010003190 putative dimerization interface [polypeptide binding]; other site 279010003191 putative ligand binding site [chemical binding]; other site 279010003192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010003193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010003194 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010003195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003196 dimer interface [polypeptide binding]; other site 279010003197 conserved gate region; other site 279010003198 putative PBP binding loops; other site 279010003199 ABC-ATPase subunit interface; other site 279010003200 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010003201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003202 dimer interface [polypeptide binding]; other site 279010003203 conserved gate region; other site 279010003204 putative PBP binding loops; other site 279010003205 ABC-ATPase subunit interface; other site 279010003206 alpha-galactosidase; Provisional; Region: PRK15076 279010003207 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 279010003208 NAD binding site [chemical binding]; other site 279010003209 sugar binding site [chemical binding]; other site 279010003210 divalent metal binding site [ion binding]; other site 279010003211 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010003212 dimer interface [polypeptide binding]; other site 279010003213 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279010003214 Putative ammonia monooxygenase; Region: AmoA; pfam05145 279010003215 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279010003216 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 279010003217 CotJB protein; Region: CotJB; pfam12652 279010003218 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010003219 dimanganese center [ion binding]; other site 279010003220 AMP-binding domain protein; Validated; Region: PRK08315 279010003221 AMP-binding enzyme; Region: AMP-binding; cl15778 279010003222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010003223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 279010003224 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 279010003225 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010003226 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 279010003227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010003228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010003229 dimerization interface [polypeptide binding]; other site 279010003230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010003231 dimer interface [polypeptide binding]; other site 279010003232 phosphorylation site [posttranslational modification] 279010003233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003234 ATP binding site [chemical binding]; other site 279010003235 Mg2+ binding site [ion binding]; other site 279010003236 G-X-G motif; other site 279010003237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003239 active site 279010003240 phosphorylation site [posttranslational modification] 279010003241 intermolecular recognition site; other site 279010003242 dimerization interface [polypeptide binding]; other site 279010003243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010003244 DNA binding site [nucleotide binding] 279010003245 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 279010003246 dinuclear metal binding motif [ion binding]; other site 279010003247 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 279010003248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010003249 dimerization interface [polypeptide binding]; other site 279010003250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003251 dimer interface [polypeptide binding]; other site 279010003252 conserved gate region; other site 279010003253 putative PBP binding loops; other site 279010003254 ABC-ATPase subunit interface; other site 279010003255 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 279010003256 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 279010003257 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 279010003258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010003259 Family description; Region: UvrD_C_2; cl15862 279010003260 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 279010003261 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279010003262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010003263 active site 279010003264 metal binding site [ion binding]; metal-binding site 279010003265 DNA binding site [nucleotide binding] 279010003266 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 279010003267 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 279010003268 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 279010003269 Walker A/P-loop; other site 279010003270 ATP binding site [chemical binding]; other site 279010003271 Q-loop/lid; other site 279010003272 ABC transporter signature motif; other site 279010003273 Walker B; other site 279010003274 D-loop; other site 279010003275 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 279010003276 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 279010003277 ABC transporter signature motif; other site 279010003278 Walker B; other site 279010003279 D-loop; other site 279010003280 H-loop/switch region; other site 279010003281 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003282 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 279010003283 Spore germination protein GerPC; Region: GerPC; pfam10737 279010003284 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 279010003285 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003286 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010003287 CotH protein; Region: CotH; pfam08757 279010003288 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 279010003289 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 279010003290 GTPase RsgA; Reviewed; Region: PRK01889 279010003291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010003292 RNA binding site [nucleotide binding]; other site 279010003293 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 279010003294 GTPase/Zn-binding domain interface [polypeptide binding]; other site 279010003295 GTP/Mg2+ binding site [chemical binding]; other site 279010003296 G4 box; other site 279010003297 G5 box; other site 279010003298 G1 box; other site 279010003299 Switch I region; other site 279010003300 G2 box; other site 279010003301 G3 box; other site 279010003302 Switch II region; other site 279010003303 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 279010003304 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 279010003305 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 279010003306 active site 279010003307 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 279010003308 dimer interface [polypeptide binding]; other site 279010003309 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010003310 Ligand Binding Site [chemical binding]; other site 279010003311 Molecular Tunnel; other site 279010003312 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 279010003313 Nitrogen regulatory protein P-II; Region: P-II; cl00412 279010003314 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 279010003315 MatE; Region: MatE; cl10513 279010003316 MatE; Region: MatE; cl10513 279010003317 Cupin domain; Region: Cupin_2; cl09118 279010003318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003319 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010003320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003321 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010003322 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010003323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010003324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010003325 DNA binding site [nucleotide binding] 279010003326 domain linker motif; other site 279010003327 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010003328 dimerization interface [polypeptide binding]; other site 279010003329 ligand binding site [chemical binding]; other site 279010003330 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010003331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003332 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010003333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010003334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003335 homodimer interface [polypeptide binding]; other site 279010003336 catalytic residue [active] 279010003337 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 279010003338 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010003339 inhibitor-cofactor binding pocket; inhibition site 279010003340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003341 catalytic residue [active] 279010003342 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 279010003343 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 279010003344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003345 catalytic residue [active] 279010003346 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279010003347 IucA / IucC family; Region: IucA_IucC; pfam04183 279010003348 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010003349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 279010003350 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 279010003351 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 279010003352 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279010003353 IucA / IucC family; Region: IucA_IucC; pfam04183 279010003354 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010003355 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010003356 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010003357 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs; Region: DHRS1-like_SDR_c; cd09763 279010003358 NAD(P) binding site [chemical binding]; other site 279010003359 putative dimer interface [polypeptide binding]; other site 279010003360 active site 279010003361 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010003362 Helix-turn-helix domains; Region: HTH; cl00088 279010003363 WYL domain; Region: WYL; cl14852 279010003364 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 279010003365 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 279010003366 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 279010003367 substrate binding pocket [chemical binding]; other site 279010003368 dimer interface [polypeptide binding]; other site 279010003369 inhibitor binding site; inhibition site 279010003370 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 279010003371 B12 binding site [chemical binding]; other site 279010003372 cobalt ligand [ion binding]; other site 279010003373 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 279010003374 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 279010003375 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 279010003376 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 279010003377 FAD binding site [chemical binding]; other site 279010003378 Protein of unknown function (DUF520); Region: DUF520; cl00723 279010003379 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 279010003380 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010003381 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010003382 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010003383 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 279010003384 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010003385 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010003386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010003387 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010003388 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 279010003389 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 279010003390 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 279010003391 active site 279010003392 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 279010003393 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010003394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010003395 motif II; other site 279010003396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010003397 esterase; Provisional; Region: PRK10566 279010003398 Domain of unknown function DUF59; Region: DUF59; cl00941 279010003399 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 279010003400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003401 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 279010003402 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 279010003403 heterotetramer interface [polypeptide binding]; other site 279010003404 active site pocket [active] 279010003405 cleavage site 279010003406 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 279010003407 nucleotide binding site [chemical binding]; other site 279010003408 N-acetyl-L-glutamate binding site [chemical binding]; other site 279010003409 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 279010003410 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010003411 inhibitor-cofactor binding pocket; inhibition site 279010003412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003413 catalytic residue [active] 279010003414 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 279010003415 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 279010003416 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 279010003417 catalytic site [active] 279010003418 subunit interface [polypeptide binding]; other site 279010003419 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 279010003420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010003421 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010003422 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 279010003423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010003424 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010003425 ornithine carbamoyltransferase; Provisional; Region: PRK00779 279010003426 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010003427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003428 Bacitracin resistance protein BacA; Region: BacA; cl00858 279010003429 YjzC-like protein; Region: YjzC; pfam14168 279010003430 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 279010003431 LytB protein; Region: LYTB; cl00507 279010003432 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 279010003433 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 279010003434 putative ligand binding site [chemical binding]; other site 279010003435 ComZ; Region: ComZ; pfam10815 279010003436 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 279010003437 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 279010003438 dimer interface [polypeptide binding]; other site 279010003439 active site 279010003440 CoA binding pocket [chemical binding]; other site 279010003441 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 279010003442 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 279010003443 dimer interface [polypeptide binding]; other site 279010003444 active site 279010003445 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 279010003446 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003447 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003448 Walker A/P-loop; other site 279010003449 ATP binding site [chemical binding]; other site 279010003450 Q-loop/lid; other site 279010003451 ABC transporter signature motif; other site 279010003452 Walker B; other site 279010003453 D-loop; other site 279010003454 H-loop/switch region; other site 279010003455 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003456 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 279010003457 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003458 Walker A/P-loop; other site 279010003459 ATP binding site [chemical binding]; other site 279010003460 Q-loop/lid; other site 279010003461 ABC transporter signature motif; other site 279010003462 Walker B; other site 279010003463 D-loop; other site 279010003464 H-loop/switch region; other site 279010003465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003466 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010003467 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 279010003468 peptide binding site [polypeptide binding]; other site 279010003469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003471 dimer interface [polypeptide binding]; other site 279010003472 conserved gate region; other site 279010003473 putative PBP binding loops; other site 279010003474 ABC-ATPase subunit interface; other site 279010003475 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010003476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003477 dimer interface [polypeptide binding]; other site 279010003478 conserved gate region; other site 279010003479 putative PBP binding loops; other site 279010003480 ABC-ATPase subunit interface; other site 279010003481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003482 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010003483 putative substrate translocation pore; other site 279010003484 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 279010003485 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 279010003486 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 279010003487 active site 279010003488 HIGH motif; other site 279010003489 dimer interface [polypeptide binding]; other site 279010003490 KMSKS motif; other site 279010003491 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 279010003492 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 279010003493 peptide binding site [polypeptide binding]; other site 279010003494 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 279010003495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003496 dimer interface [polypeptide binding]; other site 279010003497 conserved gate region; other site 279010003498 putative PBP binding loops; other site 279010003499 ABC-ATPase subunit interface; other site 279010003500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010003501 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 279010003502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003503 dimer interface [polypeptide binding]; other site 279010003504 conserved gate region; other site 279010003505 putative PBP binding loops; other site 279010003506 ABC-ATPase subunit interface; other site 279010003507 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003508 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003509 Walker A/P-loop; other site 279010003510 ATP binding site [chemical binding]; other site 279010003511 Q-loop/lid; other site 279010003512 ABC transporter signature motif; other site 279010003513 Walker B; other site 279010003514 D-loop; other site 279010003515 H-loop/switch region; other site 279010003516 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003518 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003519 Walker A/P-loop; other site 279010003520 ATP binding site [chemical binding]; other site 279010003521 Q-loop/lid; other site 279010003522 ABC transporter signature motif; other site 279010003523 Walker B; other site 279010003524 D-loop; other site 279010003525 H-loop/switch region; other site 279010003526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003527 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 279010003528 ArsC family; Region: ArsC; pfam03960 279010003529 putative catalytic residues [active] 279010003530 thiol/disulfide switch; other site 279010003531 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 279010003532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 279010003533 NMT1-like family; Region: NMT1_2; cl15260 279010003534 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 279010003535 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 279010003536 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010003537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003538 active site 279010003539 phosphorylation site [posttranslational modification] 279010003540 intermolecular recognition site; other site 279010003541 dimerization interface [polypeptide binding]; other site 279010003542 Transcriptional regulator; Region: CitT; pfam12431 279010003543 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010003544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010003545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003546 ATP binding site [chemical binding]; other site 279010003547 Mg2+ binding site [ion binding]; other site 279010003548 G-X-G motif; other site 279010003549 Competence protein CoiA-like family; Region: CoiA; cl11541 279010003550 oligoendopeptidase F; Region: pepF; TIGR00181 279010003551 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 279010003552 active site 279010003553 Zn binding site [ion binding]; other site 279010003554 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 279010003555 Thioredoxin; Region: Thioredoxin_5; pfam13743 279010003556 catalytic residues [active] 279010003557 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 279010003558 apolar tunnel; other site 279010003559 heme binding site [chemical binding]; other site 279010003560 dimerization interface [polypeptide binding]; other site 279010003561 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 279010003562 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010003563 catalytic residue [active] 279010003564 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 279010003565 putative active site [active] 279010003566 putative metal binding residues [ion binding]; other site 279010003567 signature motif; other site 279010003568 putative triphosphate binding site [ion binding]; other site 279010003569 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010003570 synthetase active site [active] 279010003571 NTP binding site [chemical binding]; other site 279010003572 metal binding site [ion binding]; metal-binding site 279010003573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 279010003574 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279010003575 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 279010003576 active site 279010003577 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 279010003578 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279010003579 active site 279010003580 metal binding site [ion binding]; metal-binding site 279010003581 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 279010003582 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 279010003583 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010003584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003585 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 279010003586 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 279010003587 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279010003588 thiamine phosphate binding site [chemical binding]; other site 279010003589 active site 279010003590 pyrophosphate binding site [ion binding]; other site 279010003591 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 279010003592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003593 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 279010003594 thiS-thiF/thiG interaction site; other site 279010003595 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 279010003596 ThiS interaction site; other site 279010003597 putative active site [active] 279010003598 tetramer interface [polypeptide binding]; other site 279010003599 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 279010003600 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279010003601 ATP binding site [chemical binding]; other site 279010003602 substrate interface [chemical binding]; other site 279010003603 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279010003604 dimer interface [polypeptide binding]; other site 279010003605 substrate binding site [chemical binding]; other site 279010003606 ATP binding site [chemical binding]; other site 279010003607 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 279010003608 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 279010003609 NAD binding site [chemical binding]; other site 279010003610 homotetramer interface [polypeptide binding]; other site 279010003611 homodimer interface [polypeptide binding]; other site 279010003612 substrate binding site [chemical binding]; other site 279010003613 active site 279010003614 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 279010003615 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 279010003616 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 279010003617 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003618 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003619 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 279010003620 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 279010003621 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 279010003622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010003623 Family description; Region: UvrD_C_2; cl15862 279010003624 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279010003625 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010003626 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010003627 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010003628 NAD binding site [chemical binding]; other site 279010003629 homodimer interface [polypeptide binding]; other site 279010003630 active site 279010003631 substrate binding site [chemical binding]; other site 279010003632 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 279010003633 active site 279010003634 tetramer interface; other site 279010003635 GtrA-like protein; Region: GtrA; cl00971 279010003636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010003637 Coenzyme A binding pocket [chemical binding]; other site 279010003638 hypothetical protein; Provisional; Region: PRK13679 279010003639 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010003640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010003641 Putative esterase; Region: Esterase; pfam00756 279010003642 DinB superfamily; Region: DinB_2; pfam12867 279010003643 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010003644 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010003645 Helix-turn-helix domains; Region: HTH; cl00088 279010003646 WYL domain; Region: WYL; cl14852 279010003647 cystathionine gamma-synthase; Reviewed; Region: PRK08247 279010003648 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010003649 homodimer interface [polypeptide binding]; other site 279010003650 substrate-cofactor binding pocket; other site 279010003651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003652 catalytic residue [active] 279010003653 cystathionine beta-lyase; Provisional; Region: PRK08064 279010003654 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010003655 homodimer interface [polypeptide binding]; other site 279010003656 substrate-cofactor binding pocket; other site 279010003657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010003658 catalytic residue [active] 279010003659 Protein of unknown function (DUF819); Region: DUF819; cl02317 279010003660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010003661 Helix-turn-helix domains; Region: HTH; cl00088 279010003662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010003663 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 279010003664 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010003665 substrate binding site [chemical binding]; other site 279010003666 active site 279010003667 maltose O-acetyltransferase; Provisional; Region: PRK10092 279010003668 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 279010003669 active site 279010003670 substrate binding site [chemical binding]; other site 279010003671 trimer interface [polypeptide binding]; other site 279010003672 CoA binding site [chemical binding]; other site 279010003673 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 279010003674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010003675 Helix-turn-helix domains; Region: HTH; cl00088 279010003676 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 279010003677 putative dimerization interface [polypeptide binding]; other site 279010003678 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 279010003679 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010003680 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 279010003681 FAD binding pocket [chemical binding]; other site 279010003682 FAD binding motif [chemical binding]; other site 279010003683 catalytic residues [active] 279010003684 NAD binding pocket [chemical binding]; other site 279010003685 phosphate binding motif [ion binding]; other site 279010003686 beta-alpha-beta structure motif; other site 279010003687 sulfite reductase subunit beta; Provisional; Region: PRK13504 279010003688 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010003689 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279010003690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010003691 Helix-turn-helix domains; Region: HTH; cl00088 279010003692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010003693 dimerization interface [polypeptide binding]; other site 279010003694 EamA-like transporter family; Region: EamA; cl01037 279010003695 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010003696 EamA-like transporter family; Region: EamA; cl01037 279010003697 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 279010003698 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010003699 putative metal binding site [ion binding]; other site 279010003700 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010003701 putative peptidoglycan binding site; other site 279010003702 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010003703 putative peptidoglycan binding site; other site 279010003704 3D domain; Region: 3D; cl01439 279010003705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010003707 putative substrate translocation pore; other site 279010003708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010003710 Helix-turn-helix domains; Region: HTH; cl00088 279010003711 Regulatory protein YrvL; Region: YrvL; pfam14184 279010003712 Protein of unknown function, DUF600; Region: DUF600; cl04640 279010003713 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010003714 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 279010003715 Protein of unknown function (DUF867); Region: DUF867; cl01713 279010003716 Domain of unknown function (DUF955); Region: DUF955; cl01076 279010003717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003718 non-specific DNA binding site [nucleotide binding]; other site 279010003719 salt bridge; other site 279010003720 sequence-specific DNA binding site [nucleotide binding]; other site 279010003721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003722 non-specific DNA binding site [nucleotide binding]; other site 279010003723 salt bridge; other site 279010003724 sequence-specific DNA binding site [nucleotide binding]; other site 279010003725 Helix-turn-helix domains; Region: HTH; cl00088 279010003726 hypothetical protein; Provisional; Region: PRK06921 279010003727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010003728 Walker A motif; other site 279010003729 ATP binding site [chemical binding]; other site 279010003730 Walker B motif; other site 279010003731 positive control sigma-like factor; Validated; Region: PRK06930 279010003732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010003733 DNA binding residues [nucleotide binding] 279010003734 Phage terminase small subunit; Region: Phage_terminase; pfam10668 279010003735 Terminase small subunit; Region: Terminase_2; cl01513 279010003736 Phage terminase large subunit; Region: Terminase_3; cl12054 279010003737 Terminase-like family; Region: Terminase_6; pfam03237 279010003738 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279010003739 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 279010003740 Phage capsid family; Region: Phage_capsid; pfam05065 279010003741 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 279010003742 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 279010003743 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 279010003744 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 279010003745 Phage XkdN-like protein; Region: XkdN; pfam08890 279010003746 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 279010003747 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 279010003748 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010003749 catalytic residue [active] 279010003750 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 279010003751 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010003752 putative peptidoglycan binding site; other site 279010003753 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 279010003754 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 279010003755 Baseplate J-like protein; Region: Baseplate_J; cl01294 279010003756 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 279010003757 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 279010003758 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 279010003759 Haemolysin XhlA; Region: XhlA; pfam10779 279010003760 Phage lysis protein, holin; Region: Phage_holin; cl04675 279010003761 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010003762 amidase catalytic site [active] 279010003763 Zn binding residues [ion binding]; other site 279010003764 substrate binding site [chemical binding]; other site 279010003765 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010003766 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010003767 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010003768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010003769 DNA-binding site [nucleotide binding]; DNA binding site 279010003770 FCD domain; Region: FCD; cl11656 279010003771 putative oxidoreductase; Provisional; Region: PRK10083 279010003772 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 279010003773 putative NAD(P) binding site [chemical binding]; other site 279010003774 catalytic Zn binding site [ion binding]; other site 279010003775 structural Zn binding site [ion binding]; other site 279010003776 mannonate dehydratase; Provisional; Region: PRK03906 279010003777 mannonate dehydratase; Region: uxuA; TIGR00695 279010003778 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 279010003779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 279010003780 putative NAD(P) binding site [chemical binding]; other site 279010003781 active site 279010003782 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 279010003783 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279010003784 putative NAD(P) binding site [chemical binding]; other site 279010003785 catalytic Zn binding site [ion binding]; other site 279010003786 structural Zn binding site [ion binding]; other site 279010003787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010003788 D-galactonate transporter; Region: 2A0114; TIGR00893 279010003789 putative substrate translocation pore; other site 279010003790 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 279010003791 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 279010003792 Phosphate transporter family; Region: PHO4; cl00396 279010003793 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 279010003794 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 279010003795 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 279010003796 Protein of unknown function, DUF624; Region: DUF624; cl02369 279010003797 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 279010003798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010003799 dimerization interface [polypeptide binding]; other site 279010003800 Histidine kinase; Region: His_kinase; pfam06580 279010003801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010003802 ATP binding site [chemical binding]; other site 279010003803 Mg2+ binding site [ion binding]; other site 279010003804 G-X-G motif; other site 279010003805 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 279010003806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010003807 active site 279010003808 phosphorylation site [posttranslational modification] 279010003809 intermolecular recognition site; other site 279010003810 dimerization interface [polypeptide binding]; other site 279010003811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010003813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010003814 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010003815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003816 dimer interface [polypeptide binding]; other site 279010003817 conserved gate region; other site 279010003818 putative PBP binding loops; other site 279010003819 ABC-ATPase subunit interface; other site 279010003820 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003822 dimer interface [polypeptide binding]; other site 279010003823 conserved gate region; other site 279010003824 putative PBP binding loops; other site 279010003825 ABC-ATPase subunit interface; other site 279010003826 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 279010003827 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 279010003828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010003830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010003831 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010003832 active site 279010003833 catalytic triad [active] 279010003834 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 279010003835 Protein of unknown function, DUF624; Region: DUF624; cl02369 279010003836 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 279010003837 metal binding site [ion binding]; metal-binding site 279010003838 active site 279010003839 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010003840 active site 279010003841 catalytic triad [active] 279010003842 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 279010003843 metal binding site [ion binding]; metal-binding site 279010003844 active site 279010003845 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 279010003846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010003847 active site 279010003848 catalytic tetrad [active] 279010003849 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010003850 active site 279010003851 catalytic triad [active] 279010003852 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010003853 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 279010003854 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010003855 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010003856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010003857 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010003858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003859 dimer interface [polypeptide binding]; other site 279010003860 conserved gate region; other site 279010003861 ABC-ATPase subunit interface; other site 279010003862 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003864 dimer interface [polypeptide binding]; other site 279010003865 conserved gate region; other site 279010003866 putative PBP binding loops; other site 279010003867 ABC-ATPase subunit interface; other site 279010003868 amino acid transporter; Region: 2A0306; TIGR00909 279010003869 Spore germination protein; Region: Spore_permease; cl15802 279010003870 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279010003871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010003872 Zn binding site [ion binding]; other site 279010003873 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279010003874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010003875 Zn binding site [ion binding]; other site 279010003876 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 279010003877 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 279010003878 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010003879 protein binding site [polypeptide binding]; other site 279010003880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010003881 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279010003882 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 279010003883 SxDxEG motif; other site 279010003884 active site 279010003885 metal binding site [ion binding]; metal-binding site 279010003886 homopentamer interface [polypeptide binding]; other site 279010003887 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010003888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003889 dimer interface [polypeptide binding]; other site 279010003890 conserved gate region; other site 279010003891 putative PBP binding loops; other site 279010003892 ABC-ATPase subunit interface; other site 279010003893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279010003894 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 279010003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010003896 putative PBP binding loops; other site 279010003897 dimer interface [polypeptide binding]; other site 279010003898 ABC-ATPase subunit interface; other site 279010003899 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279010003900 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003901 Walker A/P-loop; other site 279010003902 ATP binding site [chemical binding]; other site 279010003903 Q-loop/lid; other site 279010003904 ABC transporter signature motif; other site 279010003905 Walker B; other site 279010003906 D-loop; other site 279010003907 H-loop/switch region; other site 279010003908 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003909 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 279010003910 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 279010003911 peptide binding site [polypeptide binding]; other site 279010003912 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 279010003913 dimer interface [polypeptide binding]; other site 279010003914 catalytic triad [active] 279010003915 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 279010003916 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 279010003917 active site 279010003918 NlpC/P60 family; Region: NLPC_P60; cl11438 279010003919 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 279010003920 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010003921 Walker A/P-loop; other site 279010003922 ATP binding site [chemical binding]; other site 279010003923 Q-loop/lid; other site 279010003924 ABC transporter signature motif; other site 279010003925 Walker B; other site 279010003926 D-loop; other site 279010003927 H-loop/switch region; other site 279010003928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010003929 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 279010003930 Amidinotransferase; Region: Amidinotransf; cl12043 279010003931 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 279010003932 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010003933 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 279010003934 Pectate lyase; Region: Pec_lyase_C; cl01593 279010003935 Helix-turn-helix domains; Region: HTH; cl00088 279010003936 hypothetical protein; Validated; Region: PRK07668 279010003937 DinB superfamily; Region: DinB_2; pfam12867 279010003938 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010003939 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010003940 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010003941 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 279010003942 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 279010003943 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 279010003944 putative active site [active] 279010003945 putative substrate binding site [chemical binding]; other site 279010003946 putative cosubstrate binding site; other site 279010003947 catalytic site [active] 279010003948 gamma-glutamyl kinase; Provisional; Region: PRK05429 279010003949 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 279010003950 nucleotide binding site [chemical binding]; other site 279010003951 homotetrameric interface [polypeptide binding]; other site 279010003952 putative phosphate binding site [ion binding]; other site 279010003953 putative allosteric binding site; other site 279010003954 PUA domain; Region: PUA; cl00607 279010003955 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 279010003956 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 279010003957 putative catalytic cysteine [active] 279010003958 OsmC-like protein; Region: OsmC; cl00767 279010003959 Transcriptional regulators [Transcription]; Region: MarR; COG1846 279010003960 Helix-turn-helix domains; Region: HTH; cl00088 279010003961 OsmC-like protein; Region: OsmC; cl00767 279010003962 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 279010003963 nucleoside/Zn binding site; other site 279010003964 dimer interface [polypeptide binding]; other site 279010003965 catalytic motif [active] 279010003966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279010003967 catalytic core [active] 279010003968 Proteins of 100 residues with WXG; Region: WXG100; cl02005 279010003969 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 279010003970 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 279010003971 THF binding site; other site 279010003972 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279010003973 substrate binding site [chemical binding]; other site 279010003974 THF binding site; other site 279010003975 zinc-binding site [ion binding]; other site 279010003976 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 279010003977 active site 279010003978 catalytic residues [active] 279010003979 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 279010003980 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 279010003981 MgtE intracellular N domain; Region: MgtE_N; cl15244 279010003982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 279010003983 Divalent cation transporter; Region: MgtE; cl00786 279010003984 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010003985 Int/Topo IB signature motif; other site 279010003986 Domain of unknown function (DUF955); Region: DUF955; cl01076 279010003987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010003988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003989 non-specific DNA binding site [nucleotide binding]; other site 279010003990 salt bridge; other site 279010003991 sequence-specific DNA binding site [nucleotide binding]; other site 279010003992 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 279010003993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010003994 non-specific DNA binding site [nucleotide binding]; other site 279010003995 salt bridge; other site 279010003996 sequence-specific DNA binding site [nucleotide binding]; other site 279010003997 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 279010003998 RecT family; Region: RecT; cl04285 279010003999 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 279010004000 putative replication protein; Provisional; Region: PRK12377 279010004001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004002 Walker A motif; other site 279010004003 ATP binding site [chemical binding]; other site 279010004004 Walker B motif; other site 279010004005 arginine finger; other site 279010004006 IDEAL domain; Region: IDEAL; cl07452 279010004007 YopX protein; Region: YopX; cl09859 279010004008 YopX protein; Region: YopX; cl09859 279010004009 Endodeoxyribonuclease RusA; Region: RusA; cl01885 279010004010 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010004011 dimer interface [polypeptide binding]; other site 279010004012 ssDNA binding site [nucleotide binding]; other site 279010004013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010004014 Uncharacterized conserved protein [Function unknown]; Region: COG5484 279010004015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010004016 Phage terminase large subunit; Region: Terminase_3; cl12054 279010004017 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 279010004018 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 279010004019 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 279010004020 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 279010004021 Phage capsid family; Region: Phage_capsid; pfam05065 279010004022 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 279010004023 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 279010004024 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 279010004025 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 279010004026 Phage major tail protein 2; Region: Phage_tail_2; cl11463 279010004027 Phage protein; Region: DUF3647; cl10335 279010004028 Phage-related protein [Function unknown]; Region: COG5412 279010004029 membrane protein P6; Region: PHA01399 279010004030 Phage-related protein [Function unknown]; Region: COG5412 279010004031 Phage-related protein [Function unknown]; Region: COG4722; cl15832 279010004032 Phage tail protein; Region: Sipho_tail; pfam05709 279010004033 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 279010004034 Haemolysin XhlA; Region: XhlA; pfam10779 279010004035 Phage lysis protein, holin; Region: Phage_holin; cl04675 279010004036 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 279010004037 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 279010004038 active site 279010004039 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010004040 putative peptidoglycan binding site; other site 279010004041 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010004042 putative peptidoglycan binding site; other site 279010004043 Cupin domain; Region: Cupin_2; cl09118 279010004044 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 279010004045 dinuclear metal binding motif [ion binding]; other site 279010004046 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 279010004047 diiron binding motif [ion binding]; other site 279010004048 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010004049 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 279010004050 DNA binding residues [nucleotide binding] 279010004051 putative dimer interface [polypeptide binding]; other site 279010004052 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004053 Helix-turn-helix domains; Region: HTH; cl00088 279010004054 Helix-turn-helix domains; Region: HTH; cl00088 279010004055 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 279010004056 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 279010004057 active site 279010004058 DNA binding site [nucleotide binding] 279010004059 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 279010004060 nucleotide binding site [chemical binding]; other site 279010004061 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 279010004062 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 279010004063 putative DNA binding site [nucleotide binding]; other site 279010004064 putative homodimer interface [polypeptide binding]; other site 279010004065 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 279010004066 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 279010004067 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 279010004068 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 279010004069 PAS domain S-box; Region: sensory_box; TIGR00229 279010004070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010004071 metal binding site [ion binding]; metal-binding site 279010004072 active site 279010004073 I-site; other site 279010004074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279010004075 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010004076 Integral membrane protein TerC family; Region: TerC; cl10468 279010004077 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 279010004078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004079 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 279010004080 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010004081 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 279010004082 Peptidase family M48; Region: Peptidase_M48; cl12018 279010004083 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010004084 Cation transport protein; Region: TrkH; cl10514 279010004085 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 279010004086 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010004087 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004088 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010004089 OpgC protein; Region: OpgC_C; cl00792 279010004090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004091 PAS domain; Region: PAS_9; pfam13426 279010004092 putative active site [active] 279010004093 heme pocket [chemical binding]; other site 279010004094 PAS domain S-box; Region: sensory_box; TIGR00229 279010004095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010004096 PAS domain S-box; Region: sensory_box; TIGR00229 279010004097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010004098 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010004099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004101 dimer interface [polypeptide binding]; other site 279010004102 phosphorylation site [posttranslational modification] 279010004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004104 ATP binding site [chemical binding]; other site 279010004105 Mg2+ binding site [ion binding]; other site 279010004106 G-X-G motif; other site 279010004107 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 279010004108 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 279010004109 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 279010004110 DNA binding site [nucleotide binding] 279010004111 active site 279010004112 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 279010004113 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 279010004114 Phosphotransferase enzyme family; Region: APH; pfam01636 279010004115 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 279010004116 substrate binding site [chemical binding]; other site 279010004117 Predicted amidohydrolase [General function prediction only]; Region: COG0388 279010004118 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 279010004119 putative active site [active] 279010004120 catalytic triad [active] 279010004121 putative dimer interface [polypeptide binding]; other site 279010004122 transaminase; Reviewed; Region: PRK08068 279010004123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010004124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004125 homodimer interface [polypeptide binding]; other site 279010004126 catalytic residue [active] 279010004127 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 279010004128 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 279010004129 dimer interface [polypeptide binding]; other site 279010004130 active site 279010004131 catalytic residue [active] 279010004132 metal binding site [ion binding]; metal-binding site 279010004133 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 279010004134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004135 motif II; other site 279010004136 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 279010004137 intersubunit interface [polypeptide binding]; other site 279010004138 active site 279010004139 Zn2+ binding site [ion binding]; other site 279010004140 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 279010004141 Cupin domain; Region: Cupin_2; cl09118 279010004142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010004143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010004144 active site 279010004145 metal binding site [ion binding]; metal-binding site 279010004146 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 279010004147 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010004148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010004149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004150 dimer interface [polypeptide binding]; other site 279010004151 phosphorylation site [posttranslational modification] 279010004152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004153 ATP binding site [chemical binding]; other site 279010004154 Mg2+ binding site [ion binding]; other site 279010004155 G-X-G motif; other site 279010004156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004157 Helix-turn-helix domains; Region: HTH; cl00088 279010004158 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 279010004159 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 279010004160 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 279010004161 ligand binding site [chemical binding]; other site 279010004162 flagellar motor protein MotA; Validated; Region: PRK08124 279010004163 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 279010004164 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 279010004165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004166 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010004167 Walker A motif; other site 279010004168 ATP binding site [chemical binding]; other site 279010004169 Walker B motif; other site 279010004170 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 279010004171 arginine finger; other site 279010004172 UvrB/uvrC motif; Region: UVR; pfam02151 279010004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010004174 Walker A motif; other site 279010004175 ATP binding site [chemical binding]; other site 279010004176 Walker B motif; other site 279010004177 arginine finger; other site 279010004178 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 279010004179 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279010004180 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 279010004181 Ligand Binding Site [chemical binding]; other site 279010004182 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 279010004183 active site 279010004184 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 279010004185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 279010004186 FeS/SAM binding site; other site 279010004187 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 279010004188 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010004189 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 279010004190 DNA binding site [nucleotide binding] 279010004191 Int/Topo IB signature motif; other site 279010004192 active site 279010004193 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010004194 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279010004195 DNA binding site [nucleotide binding] 279010004196 active site 279010004197 Int/Topo IB signature motif; other site 279010004198 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 279010004199 nucleophilic elbow; other site 279010004200 catalytic triad; other site 279010004201 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 279010004202 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 279010004203 active site 279010004204 DNA binding site [nucleotide binding] 279010004205 Phage terminase, small subunit; Region: Terminase_4; cl01525 279010004206 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 279010004207 Phage Terminase; Region: Terminase_1; pfam03354 279010004208 Phage portal protein; Region: Phage_portal; pfam04860 279010004209 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279010004210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 279010004211 oligomer interface [polypeptide binding]; other site 279010004212 active site residues [active] 279010004213 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 279010004214 Phage capsid family; Region: Phage_capsid; pfam05065 279010004215 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 279010004216 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 279010004217 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 279010004218 oligomerization interface [polypeptide binding]; other site 279010004219 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 279010004220 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 279010004221 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 279010004222 Interdomain contacts; other site 279010004223 Cytokine receptor motif; other site 279010004224 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 279010004225 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 279010004226 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 279010004227 Phage-related protein [Function unknown]; Region: COG5412 279010004228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 279010004229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010004230 catalytic residue [active] 279010004231 Phage tail protein; Region: Sipho_tail; pfam05709 279010004232 hypothetical protein; Region: PHA01795 279010004233 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 279010004234 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010004235 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 279010004236 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279010004237 XkdW protein; Region: XkdW; pfam09636 279010004238 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 279010004239 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010004240 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010004241 active site 279010004242 catalytic site [active] 279010004243 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 279010004244 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010004245 amidase catalytic site [active] 279010004246 Zn binding residues [ion binding]; other site 279010004247 substrate binding site [chemical binding]; other site 279010004248 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010004249 putative peptidoglycan binding site; other site 279010004250 Phage holin; Region: Phage_holin_5; pfam06946 279010004251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010004252 Helix-turn-helix domains; Region: HTH; cl00088 279010004253 YolD-like protein; Region: YolD; pfam08863 279010004254 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 279010004255 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 279010004256 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010004257 Int/Topo IB signature motif; other site 279010004258 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 279010004259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010004260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279010004261 Protein of unknown function (DUF817); Region: DUF817; cl01520 279010004262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010004263 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 279010004264 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 279010004265 nucleophilic elbow; other site 279010004266 catalytic triad; other site 279010004267 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 279010004268 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 279010004269 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 279010004270 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010004271 MatE; Region: MatE; cl10513 279010004272 MatE; Region: MatE; cl10513 279010004273 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010004274 catalytic residues [active] 279010004275 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 279010004276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010004277 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010004278 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279010004279 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279010004280 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279010004281 active site 279010004282 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 279010004283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010004284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010004285 DNA binding site [nucleotide binding] 279010004286 domain linker motif; other site 279010004287 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 279010004288 putative dimerization interface [polypeptide binding]; other site 279010004289 putative ligand binding site [chemical binding]; other site 279010004290 CAT RNA binding domain; Region: CAT_RBD; cl03904 279010004291 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010004292 PRD domain; Region: PRD; cl15445 279010004293 PRD domain; Region: PRD; cl15445 279010004294 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 279010004295 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010004296 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010004297 active site turn [active] 279010004298 phosphorylation site [posttranslational modification] 279010004299 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 279010004300 HPr interaction site; other site 279010004301 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010004302 active site 279010004303 phosphorylation site [posttranslational modification] 279010004304 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010004305 dimerization domain swap beta strand [polypeptide binding]; other site 279010004306 regulatory protein interface [polypeptide binding]; other site 279010004307 active site 279010004308 regulatory phosphorylation site [posttranslational modification]; other site 279010004309 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 279010004310 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 279010004311 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 279010004312 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 279010004313 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 279010004314 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 279010004315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010004316 FeS/SAM binding site; other site 279010004317 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010004318 Cache domain; Region: Cache_1; pfam02743 279010004319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010004320 dimerization interface [polypeptide binding]; other site 279010004321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010004322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010004323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010004324 dimer interface [polypeptide binding]; other site 279010004325 putative CheW interface [polypeptide binding]; other site 279010004326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010004327 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 279010004328 putative NAD(P) binding site [chemical binding]; other site 279010004329 putative active site [active] 279010004330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004331 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 279010004332 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279010004333 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004334 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010004336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004337 putative active site [active] 279010004338 heme pocket [chemical binding]; other site 279010004339 PAS fold; Region: PAS; pfam00989 279010004340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004341 putative active site [active] 279010004342 heme pocket [chemical binding]; other site 279010004343 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010004344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010004345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004346 dimer interface [polypeptide binding]; other site 279010004347 phosphorylation site [posttranslational modification] 279010004348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004349 ATP binding site [chemical binding]; other site 279010004350 Mg2+ binding site [ion binding]; other site 279010004351 G-X-G motif; other site 279010004352 aminotransferase A; Validated; Region: PRK07683 279010004353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010004354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004355 homodimer interface [polypeptide binding]; other site 279010004356 catalytic residue [active] 279010004357 RDD family; Region: RDD; cl00746 279010004358 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 279010004359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010004360 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 279010004361 putative CheA interaction surface; other site 279010004362 Response regulator receiver domain; Region: Response_reg; pfam00072 279010004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010004364 active site 279010004365 phosphorylation site [posttranslational modification] 279010004366 intermolecular recognition site; other site 279010004367 dimerization interface [polypeptide binding]; other site 279010004368 YkyB-like protein; Region: YkyB; pfam14177 279010004369 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010004370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010004371 putative substrate translocation pore; other site 279010004372 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010004373 putative peptidoglycan binding site; other site 279010004374 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 279010004375 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010004376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010004377 putative active site [active] 279010004378 putative metal binding site [ion binding]; other site 279010004379 short chain dehydrogenase; Provisional; Region: PRK07677 279010004380 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 279010004381 NAD(P) binding site [chemical binding]; other site 279010004382 substrate binding site [chemical binding]; other site 279010004383 homotetramer interface [polypeptide binding]; other site 279010004384 active site 279010004385 homodimer interface [polypeptide binding]; other site 279010004386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 279010004387 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 279010004388 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 279010004389 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 279010004390 Protein of unknown function (DUF458); Region: DUF458; cl00861 279010004391 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 279010004392 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 279010004393 FOG: CBS domain [General function prediction only]; Region: COG0517 279010004394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010004395 Helix-turn-helix domains; Region: HTH; cl00088 279010004396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010004397 dimerization interface [polypeptide binding]; other site 279010004398 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010004399 BNR repeat-like domain; Region: BNR_2; pfam13088 279010004400 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010004401 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 279010004402 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 279010004403 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 279010004404 active site 279010004405 trimer interface [polypeptide binding]; other site 279010004406 substrate binding site [chemical binding]; other site 279010004407 CoA binding site [chemical binding]; other site 279010004408 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010004409 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 279010004410 metal binding site [ion binding]; metal-binding site 279010004411 putative dimer interface [polypeptide binding]; other site 279010004412 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 279010004413 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 279010004414 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 279010004415 dimer interface [polypeptide binding]; other site 279010004416 decamer (pentamer of dimers) interface [polypeptide binding]; other site 279010004417 catalytic triad [active] 279010004418 peroxidatic and resolving cysteines [active] 279010004419 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 279010004420 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010004421 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 279010004422 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 279010004423 GTP binding site; other site 279010004424 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 279010004425 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279010004426 ATP binding site [chemical binding]; other site 279010004427 substrate interface [chemical binding]; other site 279010004428 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 279010004429 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 279010004430 dimer interface [polypeptide binding]; other site 279010004431 putative functional site; other site 279010004432 putative MPT binding site; other site 279010004433 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 279010004434 Walker A motif; other site 279010004435 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 279010004436 MoaE homodimer interface [polypeptide binding]; other site 279010004437 MoaD interaction [polypeptide binding]; other site 279010004438 active site residues [active] 279010004439 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 279010004440 MoaE interaction surface [polypeptide binding]; other site 279010004441 MoeB interaction surface [polypeptide binding]; other site 279010004442 thiocarboxylated glycine; other site 279010004443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010004444 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010004445 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 279010004446 Walker A/P-loop; other site 279010004447 ATP binding site [chemical binding]; other site 279010004448 Q-loop/lid; other site 279010004449 ABC transporter signature motif; other site 279010004450 Walker B; other site 279010004451 D-loop; other site 279010004452 H-loop/switch region; other site 279010004453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010004454 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010004455 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 279010004456 Walker A/P-loop; other site 279010004457 ATP binding site [chemical binding]; other site 279010004458 Q-loop/lid; other site 279010004459 ABC transporter signature motif; other site 279010004460 Walker B; other site 279010004461 D-loop; other site 279010004462 H-loop/switch region; other site 279010004463 Yip1 domain; Region: Yip1; cl12048 279010004464 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 279010004465 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 279010004466 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010004467 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010004468 Walker A/P-loop; other site 279010004469 ATP binding site [chemical binding]; other site 279010004470 Q-loop/lid; other site 279010004471 ABC transporter signature motif; other site 279010004472 Walker B; other site 279010004473 D-loop; other site 279010004474 H-loop/switch region; other site 279010004475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010004476 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010004477 FtsX-like permease family; Region: FtsX; cl15850 279010004478 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010004479 Helix-turn-helix domains; Region: HTH; cl00088 279010004480 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010004481 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 279010004482 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279010004483 putative substrate binding site [chemical binding]; other site 279010004484 putative ATP binding site [chemical binding]; other site 279010004485 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 279010004486 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010004487 active site 279010004488 phosphorylation site [posttranslational modification] 279010004489 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010004490 P-loop; other site 279010004491 active site 279010004492 phosphorylation site [posttranslational modification] 279010004493 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010004494 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010004495 Catalytic site [active] 279010004496 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 279010004497 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010004498 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010004499 ABC transporter; Region: ABC_tran_2; pfam12848 279010004500 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010004501 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 279010004502 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 279010004503 rod-share determining protein MreBH; Provisional; Region: PRK13929 279010004504 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 279010004505 ATP binding site [chemical binding]; other site 279010004506 profilin binding site; other site 279010004507 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 279010004508 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 279010004509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010004510 putative active site [active] 279010004511 heme pocket [chemical binding]; other site 279010004512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010004513 dimer interface [polypeptide binding]; other site 279010004514 phosphorylation site [posttranslational modification] 279010004515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010004516 ATP binding site [chemical binding]; other site 279010004517 Mg2+ binding site [ion binding]; other site 279010004518 G-X-G motif; other site 279010004519 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010004520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004521 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 279010004522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010004523 adenine deaminase; Region: ade; TIGR01178 279010004524 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 279010004525 active site 279010004526 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010004527 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279010004528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010004529 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279010004530 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 279010004531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004532 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010004533 active site 279010004534 motif I; other site 279010004535 motif II; other site 279010004536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010004537 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279010004538 active site 279010004539 catalytic residues [active] 279010004540 metal binding site [ion binding]; metal-binding site 279010004541 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 279010004542 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 279010004543 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010004544 TPP-binding site [chemical binding]; other site 279010004545 tetramer interface [polypeptide binding]; other site 279010004546 heterodimer interface [polypeptide binding]; other site 279010004547 phosphorylation loop region [posttranslational modification] 279010004548 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010004549 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010004550 alpha subunit interface [polypeptide binding]; other site 279010004551 TPP binding site [chemical binding]; other site 279010004552 heterodimer interface [polypeptide binding]; other site 279010004553 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010004554 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010004555 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010004556 E3 interaction surface; other site 279010004557 lipoyl attachment site [posttranslational modification]; other site 279010004558 e3 binding domain; Region: E3_binding; pfam02817 279010004559 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 279010004560 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 279010004561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010004563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010004564 Helix-turn-helix domains; Region: HTH; cl00088 279010004565 putative transposase OrfB; Reviewed; Region: PHA02517 279010004566 Integrase core domain; Region: rve; cl01316 279010004567 Helix-turn-helix domains; Region: HTH; cl00088 279010004568 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 279010004569 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 279010004570 homodimer interface [polypeptide binding]; other site 279010004571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010004572 catalytic residue [active] 279010004573 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 279010004574 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 279010004575 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 279010004576 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 279010004577 active site 279010004578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010004579 Coenzyme A binding pocket [chemical binding]; other site 279010004580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004581 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 279010004582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004583 DNA binding residues [nucleotide binding] 279010004584 Predicted integral membrane protein [Function unknown]; Region: COG5660 279010004585 Putative zinc-finger; Region: zf-HC2; cl15806 279010004586 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 279010004587 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 279010004588 G1 box; other site 279010004589 putative GEF interaction site [polypeptide binding]; other site 279010004590 GTP/Mg2+ binding site [chemical binding]; other site 279010004591 Switch I region; other site 279010004592 G2 box; other site 279010004593 G3 box; other site 279010004594 Switch II region; other site 279010004595 G4 box; other site 279010004596 G5 box; other site 279010004597 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 279010004598 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 279010004599 YlaH-like protein; Region: YlaH; pfam14036 279010004600 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010004601 Helix-turn-helix domains; Region: HTH; cl00088 279010004602 hypothetical protein; Provisional; Region: PRK08244 279010004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004604 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 279010004605 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 279010004606 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010004607 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 279010004608 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 279010004609 putative active site [active] 279010004610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010004611 Glutaminase; Region: Glutaminase; cl00907 279010004612 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 279010004613 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010004614 pyruvate carboxylase; Reviewed; Region: PRK12999 279010004615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010004616 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010004617 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 279010004618 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 279010004619 active site 279010004620 catalytic residues [active] 279010004621 metal binding site [ion binding]; metal-binding site 279010004622 homodimer binding site [polypeptide binding]; other site 279010004623 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010004624 carboxyltransferase (CT) interaction site; other site 279010004625 biotinylation site [posttranslational modification]; other site 279010004626 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 279010004627 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 279010004628 UbiA prenyltransferase family; Region: UbiA; cl00337 279010004629 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 279010004630 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 279010004631 Cytochrome c; Region: Cytochrom_C; cl11414 279010004632 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 279010004633 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 279010004634 D-pathway; other site 279010004635 Putative ubiquinol binding site [chemical binding]; other site 279010004636 Low-spin heme (heme b) binding site [chemical binding]; other site 279010004637 Putative water exit pathway; other site 279010004638 Binuclear center (heme o3/CuB) [ion binding]; other site 279010004639 K-pathway; other site 279010004640 Putative proton exit pathway; other site 279010004641 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 279010004642 Subunit I/III interface [polypeptide binding]; other site 279010004643 Subunit III/IV interface [polypeptide binding]; other site 279010004644 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 279010004645 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 279010004646 YugN-like family; Region: YugN; pfam08868 279010004647 FOG: CBS domain [General function prediction only]; Region: COG0517 279010004648 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010004649 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 279010004650 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279010004651 Putative coat protein; Region: YlbD_coat; pfam14071 279010004652 YlbE-like protein; Region: YlbE; pfam14003 279010004653 Protein of unknown function (DUF964); Region: DUF964; cl01483 279010004654 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 279010004655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010004656 S-adenosylmethionine binding site [chemical binding]; other site 279010004657 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 279010004658 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 279010004659 active site 279010004660 (T/H)XGH motif; other site 279010004661 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 279010004662 Nucleoside recognition; Region: Gate; cl00486 279010004663 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 279010004664 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 279010004665 protein binding site [polypeptide binding]; other site 279010004666 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 279010004667 hypothetical protein; Provisional; Region: PRK13670 279010004668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 279010004669 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 279010004670 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 279010004671 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 279010004672 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 279010004673 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010004674 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 279010004675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004676 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 279010004677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 279010004678 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 279010004679 mraZ protein; Region: TIGR00242 279010004680 MraZ protein; Region: MraZ; pfam02381 279010004681 MraZ protein; Region: MraZ; pfam02381 279010004682 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 279010004683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004684 Septum formation initiator; Region: DivIC; cl11433 279010004685 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010004686 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004687 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010004688 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 279010004689 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 279010004690 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 279010004691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010004692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010004693 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 279010004694 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 279010004695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010004696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010004697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010004698 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 279010004699 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 279010004700 Mg++ binding site [ion binding]; other site 279010004701 putative catalytic motif [active] 279010004702 putative substrate binding site [chemical binding]; other site 279010004703 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 279010004704 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010004705 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010004706 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010004707 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 279010004708 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 279010004709 active site 279010004710 homodimer interface [polypeptide binding]; other site 279010004711 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 279010004712 FAD binding domain; Region: FAD_binding_4; pfam01565 279010004713 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 279010004714 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 279010004715 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 279010004716 Cell division protein FtsQ; Region: FtsQ; pfam03799 279010004717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 279010004718 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 279010004719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 279010004720 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 279010004721 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 279010004722 cell division protein FtsA; Region: ftsA; TIGR01174 279010004723 Cell division protein FtsA; Region: FtsA; cl11496 279010004724 Cell division protein FtsA; Region: FtsA; cl11496 279010004725 cell division protein FtsZ; Validated; Region: PRK09330 279010004726 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 279010004727 nucleotide binding site [chemical binding]; other site 279010004728 SulA interaction site; other site 279010004729 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010004730 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 279010004731 active site 279010004732 catalytic triad [active] 279010004733 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010004734 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 279010004735 active site 279010004736 catalytic triad [active] 279010004737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 279010004738 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 279010004739 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010004740 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 279010004741 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 279010004742 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 279010004743 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 279010004744 sporulation sigma factor SigE; Reviewed; Region: PRK08301 279010004745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004747 DNA binding residues [nucleotide binding] 279010004748 sporulation sigma factor SigG; Reviewed; Region: PRK08215 279010004749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010004750 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010004751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010004752 DNA binding residues [nucleotide binding] 279010004753 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010004754 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010004755 Walker A/P-loop; other site 279010004756 ATP binding site [chemical binding]; other site 279010004757 Q-loop/lid; other site 279010004758 ABC transporter signature motif; other site 279010004759 Walker B; other site 279010004760 D-loop; other site 279010004761 H-loop/switch region; other site 279010004762 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 279010004763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004764 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 279010004765 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 279010004766 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 279010004767 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 279010004768 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010004769 catalytic residue [active] 279010004770 Protein of unknown function (DUF552); Region: DUF552; cl00775 279010004771 YGGT family; Region: YGGT; cl00508 279010004772 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 279010004773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010004774 RNA binding surface [nucleotide binding]; other site 279010004775 DivIVA protein; Region: DivIVA; pfam05103 279010004776 DivIVA domain; Region: DivI1A_domain; TIGR03544 279010004777 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 279010004778 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279010004779 HIGH motif; other site 279010004780 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010004781 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279010004782 active site 279010004783 KMSKS motif; other site 279010004784 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 279010004785 tRNA binding surface [nucleotide binding]; other site 279010004786 anticodon binding site; other site 279010004787 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279010004788 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 279010004789 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 279010004790 lipoprotein signal peptidase; Provisional; Region: PRK14787 279010004791 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 279010004792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010004793 RNA binding surface [nucleotide binding]; other site 279010004794 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 279010004795 active site 279010004796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010004797 active site 279010004798 uracil transporter; Provisional; Region: PRK10720 279010004799 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 279010004800 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 279010004801 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010004802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004803 dihydroorotase; Validated; Region: pyrC; PRK09357 279010004804 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010004805 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 279010004806 active site 279010004807 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 279010004808 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 279010004809 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 279010004810 catalytic site [active] 279010004811 subunit interface [polypeptide binding]; other site 279010004812 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 279010004813 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010004814 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010004815 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 279010004816 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010004817 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010004818 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 279010004819 IMP binding site; other site 279010004820 dimer interface [polypeptide binding]; other site 279010004821 interdomain contacts; other site 279010004822 partial ornithine binding site; other site 279010004823 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 279010004824 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 279010004825 FAD binding pocket [chemical binding]; other site 279010004826 FAD binding motif [chemical binding]; other site 279010004827 phosphate binding motif [ion binding]; other site 279010004828 beta-alpha-beta structure motif; other site 279010004829 NAD binding pocket [chemical binding]; other site 279010004830 Iron coordination center [ion binding]; other site 279010004831 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 279010004832 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 279010004833 heterodimer interface [polypeptide binding]; other site 279010004834 active site 279010004835 FMN binding site [chemical binding]; other site 279010004836 homodimer interface [polypeptide binding]; other site 279010004837 substrate binding site [chemical binding]; other site 279010004838 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 279010004839 active site 279010004840 dimer interface [polypeptide binding]; other site 279010004841 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 279010004842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010004843 active site 279010004844 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 279010004845 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 279010004846 Active Sites [active] 279010004847 Phosphate transporter family; Region: PHO4; cl00396 279010004848 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 279010004849 ATP-sulfurylase; Region: ATPS; cd00517 279010004850 active site 279010004851 HXXH motif; other site 279010004852 flexible loop; other site 279010004853 AAA domain; Region: AAA_33; pfam13671 279010004854 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 279010004855 ligand-binding site [chemical binding]; other site 279010004856 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 279010004857 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 279010004858 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 279010004859 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 279010004860 putative active site [active] 279010004861 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 279010004862 putative active site [active] 279010004863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010004864 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 279010004865 Domain of unknown function (DUF814); Region: DUF814; pfam05670 279010004866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 279010004867 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 279010004868 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010004869 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 279010004870 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010004871 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 279010004872 hypothetical protein; Provisional; Region: PRK11820 279010004873 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 279010004874 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 279010004875 Domain of unknown function (DUF370); Region: DUF370; cl00898 279010004876 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 279010004877 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 279010004878 catalytic site [active] 279010004879 G-X2-G-X-G-K; other site 279010004880 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 279010004881 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 279010004882 Flavoprotein; Region: Flavoprotein; cl08021 279010004883 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 279010004884 primosome assembly protein PriA; Validated; Region: PRK05580 279010004885 primosome assembly protein PriA; Validated; Region: PRK05580 279010004886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010004887 ATP binding site [chemical binding]; other site 279010004888 putative Mg++ binding site [ion binding]; other site 279010004889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010004890 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279010004891 active site 279010004892 catalytic residues [active] 279010004893 metal binding site [ion binding]; metal-binding site 279010004894 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 279010004895 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 279010004896 putative active site [active] 279010004897 substrate binding site [chemical binding]; other site 279010004898 putative cosubstrate binding site; other site 279010004899 catalytic site [active] 279010004900 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 279010004901 substrate binding site [chemical binding]; other site 279010004902 16S rRNA methyltransferase B; Provisional; Region: PRK14902 279010004903 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 279010004904 putative RNA binding site [nucleotide binding]; other site 279010004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010004906 S-adenosylmethionine binding site [chemical binding]; other site 279010004907 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 279010004908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010004909 FeS/SAM binding site; other site 279010004910 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 279010004911 Protein phosphatase 2C; Region: PP2C; pfam00481 279010004912 active site 279010004913 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010004914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 279010004915 active site 279010004916 ATP binding site [chemical binding]; other site 279010004917 substrate binding site [chemical binding]; other site 279010004918 activation loop (A-loop); other site 279010004919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 279010004920 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010004921 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010004922 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279010004923 GTPase RsgA; Reviewed; Region: PRK00098 279010004924 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 279010004925 RNA binding site [nucleotide binding]; other site 279010004926 homodimer interface [polypeptide binding]; other site 279010004927 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 279010004928 GTPase/Zn-binding domain interface [polypeptide binding]; other site 279010004929 GTP/Mg2+ binding site [chemical binding]; other site 279010004930 G4 box; other site 279010004931 G5 box; other site 279010004932 G1 box; other site 279010004933 Switch I region; other site 279010004934 G2 box; other site 279010004935 G3 box; other site 279010004936 Switch II region; other site 279010004937 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 279010004938 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 279010004939 substrate binding site [chemical binding]; other site 279010004940 hexamer interface [polypeptide binding]; other site 279010004941 metal binding site [ion binding]; metal-binding site 279010004942 Thiamine pyrophosphokinase; Region: TPK; cd07995 279010004943 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 279010004944 active site 279010004945 dimerization interface [polypeptide binding]; other site 279010004946 thiamine binding site [chemical binding]; other site 279010004947 Stage V sporulation protein family; Region: SpoV; cl15455 279010004948 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 279010004949 Asp23 family; Region: Asp23; cl00574 279010004950 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 279010004951 DAK2 domain; Region: Dak2; cl03685 279010004952 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 279010004953 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 279010004954 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 279010004955 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 279010004956 putative L-serine binding site [chemical binding]; other site 279010004957 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 279010004958 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 279010004959 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 279010004960 Y-family of DNA polymerases; Region: PolY; cl12025 279010004961 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 279010004962 generic binding surface II; other site 279010004963 ssDNA binding site; other site 279010004964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010004965 ATP binding site [chemical binding]; other site 279010004966 putative Mg++ binding site [ion binding]; other site 279010004967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010004968 nucleotide binding region [chemical binding]; other site 279010004969 ATP-binding site [chemical binding]; other site 279010004970 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 279010004971 Helix-turn-helix domains; Region: HTH; cl00088 279010004972 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 279010004973 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 279010004974 Acyl transferase domain; Region: Acyl_transf_1; cl08282 279010004975 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 279010004976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 279010004977 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 279010004978 NAD(P) binding site [chemical binding]; other site 279010004979 homotetramer interface [polypeptide binding]; other site 279010004980 homodimer interface [polypeptide binding]; other site 279010004981 active site 279010004982 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010004983 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 279010004984 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279010004985 dimerization interface [polypeptide binding]; other site 279010004986 active site 279010004987 metal binding site [ion binding]; metal-binding site 279010004988 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 279010004989 dsRNA binding site [nucleotide binding]; other site 279010004990 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010004991 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 279010004992 Walker A/P-loop; other site 279010004993 ATP binding site [chemical binding]; other site 279010004994 Q-loop/lid; other site 279010004995 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 279010004996 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 279010004997 Q-loop/lid; other site 279010004998 ABC transporter signature motif; other site 279010004999 Walker B; other site 279010005000 D-loop; other site 279010005001 H-loop/switch region; other site 279010005002 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 279010005003 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 279010005004 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279010005005 P loop; other site 279010005006 GTP binding site [chemical binding]; other site 279010005007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010005008 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 279010005009 signal recognition particle protein; Provisional; Region: PRK10867 279010005010 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 279010005011 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279010005012 P loop; other site 279010005013 GTP binding site [chemical binding]; other site 279010005014 Signal peptide binding domain; Region: SRP_SPB; pfam02978 279010005015 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 279010005016 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 279010005017 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 279010005018 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 279010005019 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 279010005020 RimM N-terminal domain; Region: RimM; pfam01782 279010005021 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 279010005022 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 279010005023 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 279010005024 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 279010005025 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 279010005026 GTP/Mg2+ binding site [chemical binding]; other site 279010005027 G4 box; other site 279010005028 G5 box; other site 279010005029 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 279010005030 G1 box; other site 279010005031 G1 box; other site 279010005032 GTP/Mg2+ binding site [chemical binding]; other site 279010005033 Switch I region; other site 279010005034 G2 box; other site 279010005035 G2 box; other site 279010005036 G3 box; other site 279010005037 G3 box; other site 279010005038 Switch II region; other site 279010005039 Switch II region; other site 279010005040 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 279010005041 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010005042 active site 279010005043 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 279010005044 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 279010005045 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010005046 CoA-ligase; Region: Ligase_CoA; cl02894 279010005047 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 279010005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005049 CoA-ligase; Region: Ligase_CoA; cl02894 279010005050 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 279010005051 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 279010005052 DNA topoisomerase I; Validated; Region: PRK05582 279010005053 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 279010005054 active site 279010005055 interdomain interaction site; other site 279010005056 putative metal-binding site [ion binding]; other site 279010005057 nucleotide binding site [chemical binding]; other site 279010005058 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279010005059 domain I; other site 279010005060 DNA binding groove [nucleotide binding] 279010005061 phosphate binding site [ion binding]; other site 279010005062 domain II; other site 279010005063 domain III; other site 279010005064 nucleotide binding site [chemical binding]; other site 279010005065 catalytic site [active] 279010005066 domain IV; other site 279010005067 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279010005068 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279010005069 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 279010005070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005071 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 279010005072 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 279010005073 Int/Topo IB signature motif; other site 279010005074 active site 279010005075 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 279010005076 active site 279010005077 HslU subunit interaction site [polypeptide binding]; other site 279010005078 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 279010005079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010005080 Walker A motif; other site 279010005081 ATP binding site [chemical binding]; other site 279010005082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005083 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 279010005084 transcriptional repressor CodY; Validated; Region: PRK04158 279010005085 CodY GAF-like domain; Region: CodY; pfam06018 279010005086 Helix-turn-helix domains; Region: HTH; cl00088 279010005087 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 279010005088 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010005089 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 279010005090 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010005091 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 279010005092 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 279010005093 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 279010005094 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 279010005095 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 279010005096 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 279010005097 MgtE intracellular N domain; Region: MgtE_N; cl15244 279010005098 FliG C-terminal domain; Region: FliG_C; pfam01706 279010005099 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 279010005100 Plant ATP synthase F0; Region: YMF19; cl07975 279010005101 Flagellar assembly protein FliH; Region: FliH; pfam02108 279010005102 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 279010005103 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 279010005104 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 279010005105 Walker A motif/ATP binding site; other site 279010005106 Walker B motif; other site 279010005107 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 279010005108 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 279010005109 MgtE intracellular N domain; Region: MgtE_N; cl15244 279010005110 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 279010005111 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 279010005112 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 279010005113 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 279010005114 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 279010005115 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010005116 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 279010005117 Flagellar protein (FlbD); Region: FlbD; cl00683 279010005118 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 279010005119 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 279010005120 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 279010005121 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 279010005122 flagellar motor switch protein; Validated; Region: PRK08119 279010005123 Chemotaxis phosphatase CheX; Region: CheX; cl15816 279010005124 Chemotaxis phosphatase CheX; Region: CheX; cl15816 279010005125 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 279010005126 Response regulator receiver domain; Region: Response_reg; pfam00072 279010005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005128 active site 279010005129 phosphorylation site [posttranslational modification] 279010005130 intermolecular recognition site; other site 279010005131 dimerization interface [polypeptide binding]; other site 279010005132 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 279010005133 FliP family; Region: FliP; cl00593 279010005134 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 279010005135 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 279010005136 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 279010005137 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 279010005138 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 279010005139 FHIPEP family; Region: FHIPEP; pfam00771 279010005140 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 279010005141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005143 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 279010005144 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 279010005145 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 279010005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005147 active site 279010005148 phosphorylation site [posttranslational modification] 279010005149 intermolecular recognition site; other site 279010005150 dimerization interface [polypeptide binding]; other site 279010005151 CheB methylesterase; Region: CheB_methylest; pfam01339 279010005152 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 279010005153 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 279010005154 putative binding surface; other site 279010005155 active site 279010005156 P2 response regulator binding domain; Region: P2; pfam07194 279010005157 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 279010005158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005159 ATP binding site [chemical binding]; other site 279010005160 Mg2+ binding site [ion binding]; other site 279010005161 G-X-G motif; other site 279010005162 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 279010005163 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 279010005164 putative CheA interaction surface; other site 279010005165 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 279010005166 Chemotaxis phosphatase CheX; Region: CheX; cl15816 279010005167 CheD chemotactic sensory transduction; Region: CheD; cl00810 279010005168 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 279010005169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010005170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010005171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010005172 DNA binding residues [nucleotide binding] 279010005173 cell division protein FtsY; Provisional; Region: PRK10416 279010005174 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 279010005175 rRNA interaction site [nucleotide binding]; other site 279010005176 S8 interaction site; other site 279010005177 putative laminin-1 binding site; other site 279010005178 elongation factor Ts; Provisional; Region: tsf; PRK09377 279010005179 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 279010005180 Elongation factor TS; Region: EF_TS; pfam00889 279010005181 Elongation factor TS; Region: EF_TS; pfam00889 279010005182 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 279010005183 putative nucleotide binding site [chemical binding]; other site 279010005184 uridine monophosphate binding site [chemical binding]; other site 279010005185 homohexameric interface [polypeptide binding]; other site 279010005186 ribosome recycling factor; Reviewed; Region: frr; PRK00083 279010005187 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 279010005188 hinge region; other site 279010005189 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 279010005190 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 279010005191 catalytic residue [active] 279010005192 putative FPP diphosphate binding site; other site 279010005193 putative FPP binding hydrophobic cleft; other site 279010005194 dimer interface [polypeptide binding]; other site 279010005195 putative IPP diphosphate binding site; other site 279010005196 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 279010005197 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 279010005198 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 279010005199 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 279010005200 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 279010005201 RIP metalloprotease RseP; Region: TIGR00054 279010005202 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279010005203 active site 279010005204 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 279010005205 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 279010005206 protein binding site [polypeptide binding]; other site 279010005207 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279010005208 putative substrate binding region [chemical binding]; other site 279010005209 prolyl-tRNA synthetase; Provisional; Region: PRK09194 279010005210 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 279010005211 dimer interface [polypeptide binding]; other site 279010005212 motif 1; other site 279010005213 active site 279010005214 motif 2; other site 279010005215 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 279010005216 putative deacylase active site [active] 279010005217 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 279010005218 active site 279010005219 motif 3; other site 279010005220 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 279010005221 anticodon binding site; other site 279010005222 DNA polymerase III PolC; Validated; Region: polC; PRK00448 279010005223 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 279010005224 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 279010005225 generic binding surface II; other site 279010005226 generic binding surface I; other site 279010005227 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279010005228 active site 279010005229 substrate binding site [chemical binding]; other site 279010005230 catalytic site [active] 279010005231 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 279010005232 endoglucanase; Region: PLN02420 279010005233 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 279010005234 Cellulose binding domain; Region: CBM_3; cl03026 279010005235 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 279010005236 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 279010005237 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 279010005238 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 279010005239 ribosome maturation protein RimP; Reviewed; Region: PRK00092 279010005240 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 279010005241 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 279010005242 Sm1 motif; other site 279010005243 predicted subunit interaction site [polypeptide binding]; other site 279010005244 RNA binding pocket [nucleotide binding]; other site 279010005245 Sm2 motif; other site 279010005246 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 279010005247 NusA N-terminal domain; Region: NusA_N; pfam08529 279010005248 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 279010005249 RNA binding site [nucleotide binding]; other site 279010005250 homodimer interface [polypeptide binding]; other site 279010005251 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 279010005252 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 279010005253 G-X-X-G motif; other site 279010005254 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 279010005255 putative RNA binding cleft [nucleotide binding]; other site 279010005256 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 279010005257 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279010005258 translation initiation factor IF-2; Region: IF-2; TIGR00487 279010005259 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279010005260 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 279010005261 G1 box; other site 279010005262 putative GEF interaction site [polypeptide binding]; other site 279010005263 GTP/Mg2+ binding site [chemical binding]; other site 279010005264 Switch I region; other site 279010005265 G2 box; other site 279010005266 G3 box; other site 279010005267 Switch II region; other site 279010005268 G4 box; other site 279010005269 G5 box; other site 279010005270 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 279010005271 Translation-initiation factor 2; Region: IF-2; pfam11987 279010005272 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 279010005273 Protein of unknown function (DUF503); Region: DUF503; cl00669 279010005274 Ribosome-binding factor A; Region: RBFA; cl00542 279010005275 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 279010005276 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 279010005277 RNA binding site [nucleotide binding]; other site 279010005278 active site 279010005279 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 279010005280 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 279010005281 active site 279010005282 Riboflavin kinase; Region: Flavokinase; cl03312 279010005283 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 279010005284 16S/18S rRNA binding site [nucleotide binding]; other site 279010005285 S13e-L30e interaction site [polypeptide binding]; other site 279010005286 25S rRNA binding site [nucleotide binding]; other site 279010005287 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 279010005288 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 279010005289 RNase E interface [polypeptide binding]; other site 279010005290 trimer interface [polypeptide binding]; other site 279010005291 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 279010005292 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 279010005293 RNase E interface [polypeptide binding]; other site 279010005294 trimer interface [polypeptide binding]; other site 279010005295 active site 279010005296 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 279010005297 putative nucleic acid binding region [nucleotide binding]; other site 279010005298 G-X-X-G motif; other site 279010005299 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 279010005300 RNA binding site [nucleotide binding]; other site 279010005301 domain interface; other site 279010005302 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 279010005303 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 279010005304 NodB motif; other site 279010005305 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005306 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005307 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005308 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 279010005309 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 279010005310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005311 Flavoprotein; Region: Flavoprotein; cl08021 279010005312 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 279010005313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005314 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 279010005315 aspartate kinase I; Reviewed; Region: PRK08210 279010005316 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 279010005317 nucleotide binding site [chemical binding]; other site 279010005318 substrate binding site [chemical binding]; other site 279010005319 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 279010005320 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 279010005321 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 279010005322 dihydrodipicolinate synthase; Region: dapA; TIGR00674 279010005323 dimer interface [polypeptide binding]; other site 279010005324 active site 279010005325 catalytic residue [active] 279010005326 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279010005327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010005328 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279010005329 Clp protease; Region: CLP_protease; pfam00574 279010005330 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 279010005331 active site 279010005332 YlzJ-like protein; Region: YlzJ; pfam14035 279010005333 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005334 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 279010005335 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010005336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005337 DNA-binding site [nucleotide binding]; DNA binding site 279010005338 UTRA domain; Region: UTRA; cl01230 279010005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010005341 putative substrate translocation pore; other site 279010005342 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005343 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005344 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005345 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279010005346 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279010005347 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279010005348 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010005349 classical (c) SDRs; Region: SDR_c; cd05233 279010005350 NAD(P) binding site [chemical binding]; other site 279010005351 active site 279010005352 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 279010005353 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 279010005354 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 279010005355 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 279010005356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010005357 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 279010005358 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 279010005359 competence damage-inducible protein A; Provisional; Region: PRK00549 279010005360 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 279010005361 putative MPT binding site; other site 279010005362 Competence-damaged protein; Region: CinA; cl00666 279010005363 recombinase A; Provisional; Region: recA; PRK09354 279010005364 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 279010005365 hexamer interface [polypeptide binding]; other site 279010005366 Walker A motif; other site 279010005367 ATP binding site [chemical binding]; other site 279010005368 Walker B motif; other site 279010005369 phosphodiesterase; Provisional; Region: PRK12704 279010005370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010005371 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 279010005372 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010005373 putative active site [active] 279010005374 metal binding site [ion binding]; metal-binding site 279010005375 homodimer binding site [polypeptide binding]; other site 279010005376 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 279010005377 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 279010005378 active site 279010005379 dimer interface [polypeptide binding]; other site 279010005380 Threonine dehydrogenase; Region: TDH; cd05281 279010005381 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 279010005382 structural Zn binding site [ion binding]; other site 279010005383 catalytic Zn binding site [ion binding]; other site 279010005384 tetramer interface [polypeptide binding]; other site 279010005385 NADP binding site [chemical binding]; other site 279010005386 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 279010005387 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 279010005388 substrate-cofactor binding pocket; other site 279010005389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010005390 catalytic residue [active] 279010005391 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 279010005392 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279010005393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005394 FeS/SAM binding site; other site 279010005395 TRAM domain; Region: TRAM; cl01282 279010005396 Protein of unknown function (DUF964); Region: DUF964; cl01483 279010005397 Outer spore coat protein E (CotE); Region: CotE; pfam10628 279010005398 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 279010005399 MutS domain I; Region: MutS_I; pfam01624 279010005400 MutS domain II; Region: MutS_II; pfam05188 279010005401 MutS family domain IV; Region: MutS_IV; pfam05190 279010005402 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 279010005403 Walker A/P-loop; other site 279010005404 ATP binding site [chemical binding]; other site 279010005405 Q-loop/lid; other site 279010005406 ABC transporter signature motif; other site 279010005407 Walker B; other site 279010005408 D-loop; other site 279010005409 H-loop/switch region; other site 279010005410 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 279010005411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005412 ATP binding site [chemical binding]; other site 279010005413 Mg2+ binding site [ion binding]; other site 279010005414 G-X-G motif; other site 279010005415 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 279010005416 ATP binding site [chemical binding]; other site 279010005417 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 279010005418 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 279010005419 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010005420 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010005421 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 279010005422 P-loop, Walker A motif; other site 279010005423 Base recognition motif; other site 279010005424 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 279010005425 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 279010005426 dimer interface [polypeptide binding]; other site 279010005427 [2Fe-2S] cluster binding site [ion binding]; other site 279010005428 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010005429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005430 Coenzyme A binding pocket [chemical binding]; other site 279010005431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005432 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 279010005433 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 279010005434 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 279010005435 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 279010005436 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 279010005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005438 putative substrate translocation pore; other site 279010005439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279010005440 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 279010005441 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010005442 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010005443 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 279010005444 glycosyltransferase, MGT family; Region: MGT; TIGR01426 279010005445 active site 279010005446 TDP-binding site; other site 279010005447 acceptor substrate-binding pocket; other site 279010005448 homodimer interface [polypeptide binding]; other site 279010005449 amino acid transporter; Region: 2A0306; TIGR00909 279010005450 Coat F domain; Region: Coat_F; cl15836 279010005451 Coat F domain; Region: Coat_F; cl15836 279010005452 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 279010005453 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010005454 putative peptidoglycan binding site; other site 279010005455 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010005456 putative peptidoglycan binding site; other site 279010005457 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 279010005458 active site 279010005459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005460 Helix-turn-helix domains; Region: HTH; cl00088 279010005461 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 279010005462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005463 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010005464 NAD(P) binding site [chemical binding]; other site 279010005465 active site 279010005466 OsmC-like protein; Region: OsmC; cl00767 279010005467 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010005468 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010005469 YmaF family; Region: YmaF; pfam12788 279010005470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005471 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 279010005472 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 279010005473 Sm1 motif; other site 279010005474 intra - hexamer interaction site; other site 279010005475 inter - hexamer interaction site [polypeptide binding]; other site 279010005476 nucleotide binding pocket [chemical binding]; other site 279010005477 Sm2 motif; other site 279010005478 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010005479 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 279010005480 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 279010005481 Class I ribonucleotide reductase; Region: RNR_I; cd01679 279010005482 active site 279010005483 dimer interface [polypeptide binding]; other site 279010005484 catalytic residues [active] 279010005485 effector binding site; other site 279010005486 R2 peptide binding site; other site 279010005487 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 279010005488 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 279010005489 dimer interface [polypeptide binding]; other site 279010005490 putative radical transfer pathway; other site 279010005491 diiron center [ion binding]; other site 279010005492 tyrosyl radical; other site 279010005493 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 279010005494 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010005495 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 279010005496 trimerization site [polypeptide binding]; other site 279010005497 active site 279010005498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010005499 metal binding site 2 [ion binding]; metal-binding site 279010005500 putative DNA binding helix; other site 279010005501 metal binding site 1 [ion binding]; metal-binding site 279010005502 dimer interface [polypeptide binding]; other site 279010005503 structural Zn2+ binding site [ion binding]; other site 279010005504 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010005505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005506 DNA-binding site [nucleotide binding]; DNA binding site 279010005507 FCD domain; Region: FCD; cl11656 279010005508 EamA-like transporter family; Region: EamA; cl01037 279010005509 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010005510 active site 279010005511 metal binding site [ion binding]; metal-binding site 279010005512 Sporulation related domain; Region: SPOR; cl10051 279010005513 Protein of unknown function, DUF606; Region: DUF606; cl01273 279010005514 Protein of unknown function, DUF606; Region: DUF606; cl01273 279010005515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005516 Helix-turn-helix domains; Region: HTH; cl00088 279010005517 OsmC-like protein; Region: OsmC; cl00767 279010005518 Sodium:solute symporter family; Region: SSF; cl00456 279010005519 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 279010005520 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 279010005521 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 279010005522 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010005523 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 279010005524 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 279010005525 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 279010005526 stage V sporulation protein K; Region: spore_V_K; TIGR02881 279010005527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010005528 Walker A motif; other site 279010005529 ATP binding site [chemical binding]; other site 279010005530 Walker B motif; other site 279010005531 arginine finger; other site 279010005532 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 279010005533 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 279010005534 HflX GTPase family; Region: HflX; cd01878 279010005535 G1 box; other site 279010005536 GTP/Mg2+ binding site [chemical binding]; other site 279010005537 Switch I region; other site 279010005538 G2 box; other site 279010005539 G3 box; other site 279010005540 Switch II region; other site 279010005541 G4 box; other site 279010005542 G5 box; other site 279010005543 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 279010005544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010005545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010005546 catalytic residue [active] 279010005547 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 279010005548 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279010005549 DNA binding residues [nucleotide binding] 279010005550 glutamine synthetase, type I; Region: GlnA; TIGR00653 279010005551 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 279010005552 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 279010005553 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 279010005554 nucleotide binding site/active site [active] 279010005555 HIT family signature motif; other site 279010005556 catalytic residue [active] 279010005557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010005558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010005559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279010005561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005562 Coenzyme A binding pocket [chemical binding]; other site 279010005563 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 279010005564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010005565 Helix-turn-helix domains; Region: HTH; cl00088 279010005566 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010005567 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 279010005568 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 279010005569 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010005570 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 279010005571 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010005572 catalytic residues [active] 279010005573 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010005574 dimanganese center [ion binding]; other site 279010005575 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 279010005576 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 279010005577 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010005578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010005579 Coenzyme A binding pocket [chemical binding]; other site 279010005580 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010005581 Helix-turn-helix domains; Region: HTH; cl00088 279010005582 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 279010005583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010005584 Helix-turn-helix domains; Region: HTH; cl00088 279010005585 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 279010005586 dimer interface [polypeptide binding]; other site 279010005587 FMN binding site [chemical binding]; other site 279010005588 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279010005589 Zn binding site [ion binding]; other site 279010005590 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279010005591 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010005592 Zn binding site [ion binding]; other site 279010005593 Flavin Reductases; Region: FlaRed; cl00801 279010005594 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010005595 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 279010005596 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 279010005597 dimerization interface [polypeptide binding]; other site 279010005598 active site 279010005599 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 279010005600 LexA repressor; Validated; Region: PRK00215 279010005601 Helix-turn-helix domains; Region: HTH; cl00088 279010005602 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 279010005603 Catalytic site [active] 279010005604 cell division suppressor protein YneA; Provisional; Region: PRK14125 279010005605 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 279010005606 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010005607 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010005608 catalytic residues [active] 279010005609 catalytic nucleophile [active] 279010005610 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 279010005611 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 279010005612 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 279010005613 TPP-binding site [chemical binding]; other site 279010005614 dimer interface [polypeptide binding]; other site 279010005615 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010005616 PYR/PP interface [polypeptide binding]; other site 279010005617 dimer interface [polypeptide binding]; other site 279010005618 TPP binding site [chemical binding]; other site 279010005619 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010005620 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 279010005621 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 279010005622 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 279010005623 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 279010005624 Response regulator receiver domain; Region: Response_reg; pfam00072 279010005625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010005626 active site 279010005627 phosphorylation site [posttranslational modification] 279010005628 intermolecular recognition site; other site 279010005629 dimerization interface [polypeptide binding]; other site 279010005630 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 279010005631 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 279010005632 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 279010005633 putative dimer interface [polypeptide binding]; other site 279010005634 Small acid-soluble spore protein P family; Region: SspP; cl12105 279010005635 Small acid-soluble spore protein O family; Region: SspO; cl07943 279010005636 aconitate hydratase; Validated; Region: PRK09277 279010005637 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 279010005638 substrate binding site [chemical binding]; other site 279010005639 ligand binding site [chemical binding]; other site 279010005640 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 279010005641 substrate binding site [chemical binding]; other site 279010005642 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010005643 catalytic residues [active] 279010005644 Small acid-soluble spore protein N family; Region: SspN; cl11659 279010005645 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 279010005646 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279010005647 active site 279010005648 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 279010005649 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 279010005650 putative active site [active] 279010005651 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 279010005652 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 279010005653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005654 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 279010005655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010005656 ATP binding site [chemical binding]; other site 279010005657 Mg2+ binding site [ion binding]; other site 279010005658 G-X-G motif; other site 279010005659 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279010005660 anchoring element; other site 279010005661 dimer interface [polypeptide binding]; other site 279010005662 ATP binding site [chemical binding]; other site 279010005663 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279010005664 active site 279010005665 putative metal-binding site [ion binding]; other site 279010005666 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279010005667 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 279010005668 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 279010005669 CAP-like domain; other site 279010005670 active site 279010005671 primary dimer interface [polypeptide binding]; other site 279010005672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279010005675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005676 DNA-binding site [nucleotide binding]; DNA binding site 279010005677 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010005678 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 279010005679 putative dimerization interface [polypeptide binding]; other site 279010005680 putative ligand binding site [chemical binding]; other site 279010005681 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 279010005682 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 279010005683 putative N- and C-terminal domain interface [polypeptide binding]; other site 279010005684 putative active site [active] 279010005685 putative MgATP binding site [chemical binding]; other site 279010005686 catalytic site [active] 279010005687 metal binding site [ion binding]; metal-binding site 279010005688 putative carbohydrate binding site [chemical binding]; other site 279010005689 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 279010005690 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 279010005691 intersubunit interface [polypeptide binding]; other site 279010005692 active site 279010005693 Zn2+ binding site [ion binding]; other site 279010005694 L-arabinose isomerase; Provisional; Region: PRK02929 279010005695 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 279010005696 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010005697 trimer interface [polypeptide binding]; other site 279010005698 substrate binding site [chemical binding]; other site 279010005699 Mn binding site [ion binding]; other site 279010005700 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010005701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005702 putative substrate translocation pore; other site 279010005703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005704 acetoin reductase; Validated; Region: PRK08643 279010005705 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 279010005706 NAD binding site [chemical binding]; other site 279010005707 homotetramer interface [polypeptide binding]; other site 279010005708 homodimer interface [polypeptide binding]; other site 279010005709 active site 279010005710 substrate binding site [chemical binding]; other site 279010005711 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010005712 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010005713 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 279010005714 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 279010005715 nitrate reductase, beta subunit; Region: narH; TIGR01660 279010005716 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 279010005717 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 279010005718 [4Fe-4S] binding site [ion binding]; other site 279010005719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005720 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005721 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279010005722 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 279010005723 molybdopterin cofactor binding site; other site 279010005724 Uncharacterized conserved protein [Function unknown]; Region: COG2461 279010005725 Family of unknown function (DUF438); Region: DUF438; pfam04282 279010005726 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 279010005727 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 279010005728 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 279010005729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005730 FeS/SAM binding site; other site 279010005731 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 279010005732 YwiC-like protein; Region: YwiC; pfam14256 279010005733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010005734 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 279010005735 ligand binding site [chemical binding]; other site 279010005736 flexible hinge region; other site 279010005737 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279010005738 putative switch regulator; other site 279010005739 non-specific DNA interactions [nucleotide binding]; other site 279010005740 DNA binding site [nucleotide binding] 279010005741 sequence specific DNA binding site [nucleotide binding]; other site 279010005742 putative cAMP binding site [chemical binding]; other site 279010005743 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 279010005744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005745 putative substrate translocation pore; other site 279010005746 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 279010005747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 279010005748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010005749 ligand binding site [chemical binding]; other site 279010005750 flexible hinge region; other site 279010005751 Helix-turn-helix domains; Region: HTH; cl00088 279010005752 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 279010005753 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 279010005754 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 279010005755 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 279010005756 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 279010005757 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 279010005758 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 279010005759 Cellulose binding domain; Region: CBM_3; cl03026 279010005760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010005761 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010005762 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 279010005763 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010005766 S-adenosylmethionine binding site [chemical binding]; other site 279010005767 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010005768 Helix-turn-helix domains; Region: HTH; cl00088 279010005769 Right handed beta helix region; Region: Beta_helix; pfam13229 279010005770 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 279010005771 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 279010005772 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 279010005773 putative NAD(P) binding site [chemical binding]; other site 279010005774 putative substrate binding site [chemical binding]; other site 279010005775 catalytic Zn binding site [ion binding]; other site 279010005776 structural Zn binding site [ion binding]; other site 279010005777 dimer interface [polypeptide binding]; other site 279010005778 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010005779 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 279010005780 DNA binding residues [nucleotide binding] 279010005781 putative dimer interface [polypeptide binding]; other site 279010005782 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010005783 dimerization domain swap beta strand [polypeptide binding]; other site 279010005784 regulatory protein interface [polypeptide binding]; other site 279010005785 active site 279010005786 regulatory phosphorylation site [posttranslational modification]; other site 279010005787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010005788 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 279010005789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010005790 substrate binding site [chemical binding]; other site 279010005791 oxyanion hole (OAH) forming residues; other site 279010005792 trimer interface [polypeptide binding]; other site 279010005793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 279010005794 enoyl-CoA hydratase; Provisional; Region: PRK07658 279010005795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010005796 substrate binding site [chemical binding]; other site 279010005797 oxyanion hole (OAH) forming residues; other site 279010005798 trimer interface [polypeptide binding]; other site 279010005799 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 279010005800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010005801 tetrameric interface [polypeptide binding]; other site 279010005802 NAD binding site [chemical binding]; other site 279010005803 catalytic residues [active] 279010005804 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 279010005805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005806 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 279010005807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010005808 active site 279010005809 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 279010005810 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 279010005811 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 279010005812 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010005813 P-loop; other site 279010005814 active site 279010005815 phosphorylation site [posttranslational modification] 279010005816 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010005817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010005818 active site 279010005819 phosphorylation site [posttranslational modification] 279010005820 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010005821 Helix-turn-helix domains; Region: HTH; cl00088 279010005822 Helix-turn-helix domains; Region: HTH; cl00088 279010005823 PRD domain; Region: PRD; cl15445 279010005824 PRD domain; Region: PRD; cl15445 279010005825 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010005826 P-loop; other site 279010005827 active site 279010005828 phosphorylation site [posttranslational modification] 279010005829 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010005830 active site 279010005831 phosphorylation site [posttranslational modification] 279010005832 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279010005833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010005834 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010005835 Walker A/P-loop; other site 279010005836 ATP binding site [chemical binding]; other site 279010005837 Q-loop/lid; other site 279010005838 ABC transporter signature motif; other site 279010005839 Walker B; other site 279010005840 D-loop; other site 279010005841 H-loop/switch region; other site 279010005842 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010005843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010005844 DNA-binding site [nucleotide binding]; DNA binding site 279010005845 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 279010005846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 279010005847 putative NAD(P) binding site [chemical binding]; other site 279010005848 active site 279010005849 mannonate dehydratase; Provisional; Region: PRK03906 279010005850 mannonate dehydratase; Region: uxuA; TIGR00695 279010005851 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 279010005852 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 279010005853 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 279010005854 putative active site [active] 279010005855 putative catalytic site [active] 279010005856 DctM-like transporters; Region: DctM; pfam06808 279010005857 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 279010005858 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 279010005859 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 279010005860 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 279010005861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010005862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010005863 DNA binding site [nucleotide binding] 279010005864 domain linker motif; other site 279010005865 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 279010005866 putative dimerization interface [polypeptide binding]; other site 279010005867 putative ligand binding site [chemical binding]; other site 279010005868 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010005869 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 279010005870 active site 279010005871 arsenical pump membrane protein; Provisional; Region: PRK15445 279010005872 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 279010005873 transmembrane helices; other site 279010005874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010005875 dimerization interface [polypeptide binding]; other site 279010005876 putative DNA binding site [nucleotide binding]; other site 279010005877 putative Zn2+ binding site [ion binding]; other site 279010005878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 279010005879 Protein of unknown function (DUF419); Region: DUF419; cl15265 279010005880 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 279010005881 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 279010005882 putative catalytic site [active] 279010005883 putative metal binding site [ion binding]; other site 279010005884 putative phosphate binding site [ion binding]; other site 279010005885 Sugar transport protein; Region: Sugar_transport; pfam06800 279010005886 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 279010005887 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 279010005888 DHH family; Region: DHH; pfam01368 279010005889 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 279010005890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010005891 FeS/SAM binding site; other site 279010005892 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 279010005893 Pyruvate formate lyase 1; Region: PFL1; cd01678 279010005894 coenzyme A binding site [chemical binding]; other site 279010005895 active site 279010005896 catalytic residues [active] 279010005897 glycine loop; other site 279010005898 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279010005899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010005900 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010005901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010005902 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 279010005903 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 279010005904 acetyl-CoA synthetase; Provisional; Region: PRK00174 279010005905 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 279010005906 AMP-binding enzyme; Region: AMP-binding; cl15778 279010005907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010005908 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 279010005909 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010005910 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010005911 enoyl-CoA hydratase; Provisional; Region: PRK07657 279010005912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010005913 substrate binding site [chemical binding]; other site 279010005914 oxyanion hole (OAH) forming residues; other site 279010005915 trimer interface [polypeptide binding]; other site 279010005916 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 279010005917 active site 279010005918 catalytic residues [active] 279010005919 metal binding site [ion binding]; metal-binding site 279010005920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010005921 carboxyltransferase (CT) interaction site; other site 279010005922 biotinylation site [posttranslational modification]; other site 279010005923 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 279010005924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010005925 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010005926 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 279010005927 AMP-binding domain protein; Validated; Region: PRK08315 279010005928 AMP-binding enzyme; Region: AMP-binding; cl15778 279010005929 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010005930 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010005931 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010005932 FAD binding site [chemical binding]; other site 279010005933 homotetramer interface [polypeptide binding]; other site 279010005934 substrate binding pocket [chemical binding]; other site 279010005935 catalytic base [active] 279010005936 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010005937 Helix-turn-helix domains; Region: HTH; cl00088 279010005938 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 279010005939 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 279010005940 putative catalytic cysteine [active] 279010005941 gamma-glutamyl kinase; Provisional; Region: PRK13402 279010005942 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 279010005943 nucleotide binding site [chemical binding]; other site 279010005944 homotetrameric interface [polypeptide binding]; other site 279010005945 putative phosphate binding site [ion binding]; other site 279010005946 putative allosteric binding site; other site 279010005947 PUA domain; Region: PUA; cl00607 279010005948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005949 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 279010005950 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010005951 Phosphate transporter family; Region: PHO4; cl00396 279010005952 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 279010005953 Active Sites [active] 279010005954 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 279010005955 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010005956 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010005957 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 279010005958 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 279010005959 active site pocket [active] 279010005960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010005961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010005962 putative substrate translocation pore; other site 279010005963 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010005964 Ligand binding site; other site 279010005965 Putative Catalytic site; other site 279010005966 DXD motif; other site 279010005967 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 279010005968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010005969 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 279010005970 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 279010005971 active site 279010005972 dimer interface [polypeptide binding]; other site 279010005973 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 279010005974 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 279010005975 active site 279010005976 FMN binding site [chemical binding]; other site 279010005977 substrate binding site [chemical binding]; other site 279010005978 3Fe-4S cluster binding site [ion binding]; other site 279010005979 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 279010005980 domain interface; other site 279010005981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010005982 Helix-turn-helix domains; Region: HTH; cl00088 279010005983 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 279010005984 putative dimerization interface [polypeptide binding]; other site 279010005985 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 279010005986 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 279010005987 Sulfatase; Region: Sulfatase; cl10460 279010005988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010005989 Helix-turn-helix domains; Region: HTH; cl00088 279010005990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010005991 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010005992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010005993 Walker A/P-loop; other site 279010005994 ATP binding site [chemical binding]; other site 279010005995 Q-loop/lid; other site 279010005996 ABC transporter signature motif; other site 279010005997 Walker B; other site 279010005998 D-loop; other site 279010005999 H-loop/switch region; other site 279010006000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010006001 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010006002 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 279010006003 Walker A/P-loop; other site 279010006004 ATP binding site [chemical binding]; other site 279010006005 Q-loop/lid; other site 279010006006 ABC transporter signature motif; other site 279010006007 Walker B; other site 279010006008 D-loop; other site 279010006009 H-loop/switch region; other site 279010006010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010006011 classical (c) SDRs; Region: SDR_c; cd05233 279010006012 NAD(P) binding site [chemical binding]; other site 279010006013 active site 279010006014 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010006015 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010006016 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 279010006017 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010006018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006019 putative substrate translocation pore; other site 279010006020 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 279010006021 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 279010006022 putative [4Fe-4S] binding site [ion binding]; other site 279010006023 putative molybdopterin cofactor binding site [chemical binding]; other site 279010006024 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 279010006025 putative molybdopterin cofactor binding site; other site 279010006026 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006027 Helix-turn-helix domains; Region: HTH; cl00088 279010006028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006029 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010006030 Spore germination protein; Region: Spore_permease; cl15802 279010006031 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 279010006032 Spore germination protein; Region: Spore_permease; cl15802 279010006033 Spore germination protein; Region: Spore_permease; cl15802 279010006034 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010006035 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010006036 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010006037 ABC transporter; Region: ABC_tran_2; pfam12848 279010006038 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010006039 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010006040 Cache domain; Region: Cache_1; pfam02743 279010006041 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 279010006042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010006043 dimerization interface [polypeptide binding]; other site 279010006044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010006045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010006046 dimer interface [polypeptide binding]; other site 279010006047 putative CheW interface [polypeptide binding]; other site 279010006048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010006049 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 279010006050 dimer interface [polypeptide binding]; other site 279010006051 putative tRNA-binding site [nucleotide binding]; other site 279010006052 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 279010006053 active site 279010006054 catalytic triad [active] 279010006055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006056 Helix-turn-helix domains; Region: HTH; cl00088 279010006057 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 279010006058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006059 Helix-turn-helix domains; Region: HTH; cl00088 279010006060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010006061 DinB superfamily; Region: DinB_2; pfam12867 279010006062 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010006063 YndJ-like protein; Region: YndJ; pfam14158 279010006064 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 279010006065 DoxX-like family; Region: DoxX_3; pfam13781 279010006066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006067 WHG domain; Region: WHG; pfam13305 279010006068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010006069 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010006070 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 279010006071 Predicted transcriptional regulator [Transcription]; Region: COG2378 279010006072 Helix-turn-helix domains; Region: HTH; cl00088 279010006073 WYL domain; Region: WYL; cl14852 279010006074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010006075 dimerization interface [polypeptide binding]; other site 279010006076 putative DNA binding site [nucleotide binding]; other site 279010006077 putative Zn2+ binding site [ion binding]; other site 279010006078 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010006079 amino acid transporter; Region: 2A0306; TIGR00909 279010006080 Spore germination protein; Region: Spore_permease; cl15802 279010006081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 279010006082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010006083 catalytic residue [active] 279010006084 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279010006085 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 279010006086 NAD(P) binding site [chemical binding]; other site 279010006087 homodimer interface [polypeptide binding]; other site 279010006088 substrate binding site [chemical binding]; other site 279010006089 active site 279010006090 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 279010006091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010006092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 279010006093 Protein of unknown function (DUF420); Region: DUF420; cl00989 279010006094 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006095 putative transporter; Provisional; Region: PRK10484 279010006096 Sodium:solute symporter family; Region: SSF; cl00456 279010006097 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006098 putative peptidoglycan binding site; other site 279010006099 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006100 putative peptidoglycan binding site; other site 279010006101 3D domain; Region: 3D; cl01439 279010006102 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 279010006103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010006104 ATP binding site [chemical binding]; other site 279010006105 putative Mg++ binding site [ion binding]; other site 279010006106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010006107 nucleotide binding region [chemical binding]; other site 279010006108 ATP-binding site [chemical binding]; other site 279010006109 RQC domain; Region: RQC; cl09632 279010006110 HRDC domain; Region: HRDC; cl02578 279010006111 Putative motility protein; Region: YjfB_motility; pfam14070 279010006112 Protein of unknown function (DUF419); Region: DUF419; cl15265 279010006113 Restriction endonuclease; Region: Mrr_cat; cl00516 279010006114 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 279010006115 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 279010006116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 279010006117 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 279010006118 4Fe-4S binding domain; Region: Fer4; cl02805 279010006119 4Fe-4S binding domain; Region: Fer4; cl02805 279010006120 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 279010006121 [4Fe-4S] binding site [ion binding]; other site 279010006122 molybdopterin cofactor binding site; other site 279010006123 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 279010006124 molybdopterin cofactor binding site; other site 279010006125 Flagellar protein YcgR; Region: YcgR_2; pfam12945 279010006126 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 279010006127 PilZ domain; Region: PilZ; cl01260 279010006128 V-type ATP synthase subunit I; Validated; Region: PRK05771 279010006129 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 279010006130 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 279010006131 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 279010006132 hypothetical protein; Provisional; Region: PRK08204 279010006133 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010006134 active site 279010006135 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010006136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006137 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010006138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006139 LysE type translocator; Region: LysE; cl00565 279010006140 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 279010006141 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 279010006142 nudix motif; other site 279010006143 phosphoenolpyruvate synthase; Validated; Region: PRK06241 279010006144 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279010006145 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 279010006146 Helix-turn-helix domains; Region: HTH; cl00088 279010006147 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279010006148 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 279010006149 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010006150 DinB superfamily; Region: DinB_2; pfam12867 279010006151 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010006152 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 279010006153 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 279010006154 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 279010006155 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010006156 NAD(P) binding site [chemical binding]; other site 279010006157 catalytic residues [active] 279010006158 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010006159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006160 putative substrate translocation pore; other site 279010006161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010006162 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006163 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 279010006164 active site 279010006165 catalytic motif [active] 279010006166 Zn binding site [ion binding]; other site 279010006167 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 279010006168 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 279010006169 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 279010006170 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 279010006171 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 279010006172 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 279010006173 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 279010006174 Membrane transport protein; Region: Mem_trans; cl09117 279010006175 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 279010006176 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010006177 E3 interaction surface; other site 279010006178 lipoyl attachment site [posttranslational modification]; other site 279010006179 e3 binding domain; Region: E3_binding; pfam02817 279010006180 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 279010006181 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 279010006182 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 279010006183 TPP-binding site [chemical binding]; other site 279010006184 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 279010006185 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 279010006186 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 279010006187 metal ion-dependent adhesion site (MIDAS); other site 279010006188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010006189 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 279010006190 Walker A motif; other site 279010006191 ATP binding site [chemical binding]; other site 279010006192 Walker B motif; other site 279010006193 arginine finger; other site 279010006194 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 279010006195 E-class dimer interface [polypeptide binding]; other site 279010006196 P-class dimer interface [polypeptide binding]; other site 279010006197 active site 279010006198 Cu2+ binding site [ion binding]; other site 279010006199 Zn2+ binding site [ion binding]; other site 279010006200 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006201 putative peptidoglycan binding site; other site 279010006202 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006203 putative peptidoglycan binding site; other site 279010006204 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006205 putative peptidoglycan binding site; other site 279010006206 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006207 putative peptidoglycan binding site; other site 279010006208 NlpC/P60 family; Region: NLPC_P60; cl11438 279010006209 multidrug efflux protein; Reviewed; Region: PRK01766 279010006210 MatE; Region: MatE; cl10513 279010006211 MatE; Region: MatE; cl10513 279010006212 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 279010006213 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 279010006214 Predicted permeases [General function prediction only]; Region: RarD; COG2962 279010006215 EamA-like transporter family; Region: EamA; cl01037 279010006216 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 279010006217 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 279010006218 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279010006219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006220 NAD(P) binding site [chemical binding]; other site 279010006221 active site 279010006222 Helix-turn-helix domains; Region: HTH; cl00088 279010006223 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 279010006224 dimer interface [polypeptide binding]; other site 279010006225 FMN binding site [chemical binding]; other site 279010006226 Predicted esterase [General function prediction only]; Region: COG0400 279010006227 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 279010006228 nucleophilic elbow; other site 279010006229 catalytic triad; other site 279010006230 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 279010006231 Sodium:solute symporter family; Region: SSF; cl00456 279010006232 Helix-turn-helix domains; Region: HTH; cl00088 279010006233 Helix-turn-helix domains; Region: HTH; cl00088 279010006234 putative transposase OrfB; Reviewed; Region: PHA02517 279010006235 Integrase core domain; Region: rve; cl01316 279010006236 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 279010006237 C-terminal peptidase (prc); Region: prc; TIGR00225 279010006238 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 279010006239 protein binding site [polypeptide binding]; other site 279010006240 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 279010006241 Catalytic dyad [active] 279010006242 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010006243 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279010006244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006245 S-adenosylmethionine binding site [chemical binding]; other site 279010006246 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 279010006247 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 279010006248 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 279010006249 Predicted permeases [General function prediction only]; Region: COG0701 279010006250 Predicted permease; Region: DUF318; pfam03773 279010006251 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 279010006252 YodL-like; Region: YodL; pfam14191 279010006253 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 279010006254 active site 279010006255 YozD-like protein; Region: YozD; pfam14162 279010006256 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 279010006257 YokU-like protein; Region: YokU; cl15819 279010006258 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 279010006259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010006260 FeS/SAM binding site; other site 279010006261 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 279010006262 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 279010006263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006264 Coenzyme A binding pocket [chemical binding]; other site 279010006265 acetylornithine deacetylase; Validated; Region: PRK06915 279010006266 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 279010006267 metal binding site [ion binding]; metal-binding site 279010006268 dimer interface [polypeptide binding]; other site 279010006269 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010006270 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010006271 hypothetical protein; Provisional; Region: PRK06917 279010006272 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010006273 inhibitor-cofactor binding pocket; inhibition site 279010006274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006275 catalytic residue [active] 279010006276 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010006277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006278 putative substrate translocation pore; other site 279010006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006280 Coenzyme A binding pocket [chemical binding]; other site 279010006281 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 279010006282 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 279010006283 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 279010006284 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010006285 Helix-turn-helix domains; Region: HTH; cl00088 279010006286 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 279010006287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010006288 metal binding site [ion binding]; metal-binding site 279010006289 active site 279010006290 I-site; other site 279010006291 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 279010006292 MatE; Region: MatE; cl10513 279010006293 MatE; Region: MatE; cl10513 279010006294 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 279010006295 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 279010006296 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 279010006297 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 279010006298 active site 279010006299 catalytic triad [active] 279010006300 oxyanion hole [active] 279010006301 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 279010006302 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 279010006303 Cu(I) binding site [ion binding]; other site 279010006304 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 279010006305 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 279010006306 threonine dehydratase; Validated; Region: PRK08639 279010006307 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 279010006308 tetramer interface [polypeptide binding]; other site 279010006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006310 catalytic residue [active] 279010006311 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 279010006312 putative Ile/Val binding site [chemical binding]; other site 279010006313 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 279010006314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010006315 Walker A motif; other site 279010006316 ATP binding site [chemical binding]; other site 279010006317 Walker B motif; other site 279010006318 arginine finger; other site 279010006319 Haemolysin-III related; Region: HlyIII; cl03831 279010006320 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006321 putative acyl-acceptor binding pocket; other site 279010006322 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 279010006323 folate binding site [chemical binding]; other site 279010006324 NADP+ binding site [chemical binding]; other site 279010006325 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 279010006326 tetramer interfaces [polypeptide binding]; other site 279010006327 binuclear metal-binding site [ion binding]; other site 279010006328 YpjP-like protein; Region: YpjP; pfam14005 279010006329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006330 Disulphide isomerase; Region: Disulph_isomer; pfam06491 279010006331 Dehydratase family; Region: ILVD_EDD; cl00340 279010006332 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 279010006333 Virulence factor; Region: Virulence_fact; pfam13769 279010006334 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 279010006335 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 279010006336 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 279010006337 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010006338 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 279010006339 catalytic residues [active] 279010006340 dimer interface [polypeptide binding]; other site 279010006341 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 279010006342 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 279010006343 Potassium binding sites [ion binding]; other site 279010006344 Cesium cation binding sites [ion binding]; other site 279010006345 homoserine O-succinyltransferase; Provisional; Region: PRK05368 279010006346 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 279010006347 proposed active site lysine [active] 279010006348 conserved cys residue [active] 279010006349 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 279010006350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010006351 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 279010006352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 279010006353 DNA-binding site [nucleotide binding]; DNA binding site 279010006354 RNA-binding motif; other site 279010006355 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 279010006356 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 279010006357 hypothetical protein; Validated; Region: PRK07708 279010006358 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 279010006359 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010006360 active site 279010006361 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 279010006362 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 279010006363 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010006364 active site 279010006365 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 279010006366 5'-3' exonuclease; Region: 53EXOc; smart00475 279010006367 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279010006368 active site 279010006369 metal binding site 1 [ion binding]; metal-binding site 279010006370 putative 5' ssDNA interaction site; other site 279010006371 metal binding site 3; metal-binding site 279010006372 metal binding site 2 [ion binding]; metal-binding site 279010006373 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279010006374 putative DNA binding site [nucleotide binding]; other site 279010006375 putative metal binding site [ion binding]; other site 279010006376 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 279010006377 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 279010006378 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 279010006379 Dynamin family; Region: Dynamin_N; pfam00350 279010006380 G1 box; other site 279010006381 GTP/Mg2+ binding site [chemical binding]; other site 279010006382 G2 box; other site 279010006383 Switch I region; other site 279010006384 G3 box; other site 279010006385 Switch II region; other site 279010006386 G4 box; other site 279010006387 G5 box; other site 279010006388 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 279010006389 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006390 G2 box; other site 279010006391 Switch I region; other site 279010006392 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 279010006393 G2 box; other site 279010006394 G3 box; other site 279010006395 Switch II region; other site 279010006396 GTP/Mg2+ binding site [chemical binding]; other site 279010006397 G4 box; other site 279010006398 G5 box; other site 279010006399 Phospholipid methyltransferase; Region: PEMT; cl00763 279010006400 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 279010006401 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 279010006402 malonyl-CoA binding site [chemical binding]; other site 279010006403 dimer interface [polypeptide binding]; other site 279010006404 active site 279010006405 product binding site; other site 279010006406 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279010006407 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006408 xanthine permease; Region: pbuX; TIGR03173 279010006409 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 279010006410 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 279010006411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010006412 active site 279010006413 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 279010006414 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 279010006415 active site 279010006416 Zn binding site [ion binding]; other site 279010006417 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 279010006418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006420 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 279010006421 THUMP domain; Region: THUMP; cl12076 279010006422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006423 cell division protein GpsB; Provisional; Region: PRK14127 279010006424 DivIVA domain; Region: DivI1A_domain; TIGR03544 279010006425 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 279010006426 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 279010006427 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 279010006428 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 279010006429 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 279010006430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010006431 ATP binding site [chemical binding]; other site 279010006432 putative Mg++ binding site [ion binding]; other site 279010006433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010006434 nucleotide binding region [chemical binding]; other site 279010006435 ATP-binding site [chemical binding]; other site 279010006436 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 279010006437 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 279010006438 HPr interaction site; other site 279010006439 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010006440 active site 279010006441 phosphorylation site [posttranslational modification] 279010006442 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 279010006443 YppG-like protein; Region: YppG; pfam14179 279010006444 YppF-like protein; Region: YppF; pfam14178 279010006445 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 279010006446 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 279010006447 Recombination protein U; Region: RecU; cl01314 279010006448 Transglycosylase; Region: Transgly; cl07896 279010006449 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010006450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010006451 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 279010006452 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 279010006453 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279010006454 minor groove reading motif; other site 279010006455 helix-hairpin-helix signature motif; other site 279010006456 substrate binding pocket [chemical binding]; other site 279010006457 active site 279010006458 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 279010006459 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 279010006460 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 279010006461 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 279010006462 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 279010006463 putative dimer interface [polypeptide binding]; other site 279010006464 putative anticodon binding site; other site 279010006465 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 279010006466 homodimer interface [polypeptide binding]; other site 279010006467 motif 1; other site 279010006468 motif 2; other site 279010006469 active site 279010006470 motif 3; other site 279010006471 aspartate aminotransferase; Provisional; Region: PRK05764 279010006472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010006473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006474 homodimer interface [polypeptide binding]; other site 279010006475 catalytic residue [active] 279010006476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 279010006477 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 279010006478 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 279010006479 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279010006480 active site 279010006481 substrate binding site [chemical binding]; other site 279010006482 catalytic site [active] 279010006483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006485 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 279010006486 tetramerization interface [polypeptide binding]; other site 279010006487 active site 279010006488 pantoate--beta-alanine ligase; Region: panC; TIGR00018 279010006489 Pantoate-beta-alanine ligase; Region: PanC; cd00560 279010006490 active site 279010006491 ATP-binding site [chemical binding]; other site 279010006492 pantoate-binding site; other site 279010006493 HXXH motif; other site 279010006494 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 279010006495 oligomerization interface [polypeptide binding]; other site 279010006496 active site 279010006497 metal binding site [ion binding]; metal-binding site 279010006498 Helix-turn-helix domains; Region: HTH; cl00088 279010006499 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 279010006500 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 279010006501 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 279010006502 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 279010006503 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 279010006504 active site 279010006505 NTP binding site [chemical binding]; other site 279010006506 metal binding triad [ion binding]; metal-binding site 279010006507 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 279010006508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010006509 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 279010006510 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 279010006511 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 279010006512 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 279010006513 active site 279010006514 dimer interfaces [polypeptide binding]; other site 279010006515 catalytic residues [active] 279010006516 dihydrodipicolinate reductase; Provisional; Region: PRK00048 279010006517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006518 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 279010006519 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 279010006520 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010006521 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010006522 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010006523 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010006524 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 279010006525 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 279010006526 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 279010006527 Cytochrome c; Region: Cytochrom_C; cl11414 279010006528 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 279010006529 interchain domain interface [polypeptide binding]; other site 279010006530 intrachain domain interface; other site 279010006531 heme bH binding site [chemical binding]; other site 279010006532 Qi binding site; other site 279010006533 heme bL binding site [chemical binding]; other site 279010006534 Qo binding site; other site 279010006535 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 279010006536 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 279010006537 iron-sulfur cluster [ion binding]; other site 279010006538 [2Fe-2S] cluster binding site [ion binding]; other site 279010006539 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 279010006540 hypothetical protein; Provisional; Region: PRK03636 279010006541 UPF0302 domain; Region: UPF0302; pfam08864 279010006542 IDEAL domain; Region: IDEAL; cl07452 279010006543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006544 TPR motif; other site 279010006545 binding surface 279010006546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006547 binding surface 279010006548 TPR motif; other site 279010006549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010006550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006551 binding surface 279010006552 TPR motif; other site 279010006553 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 279010006554 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 279010006555 hinge; other site 279010006556 active site 279010006557 prephenate dehydrogenase; Validated; Region: PRK06545 279010006558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006559 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 279010006560 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 279010006561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010006562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006563 homodimer interface [polypeptide binding]; other site 279010006564 catalytic residue [active] 279010006565 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 279010006566 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 279010006567 substrate binding site [chemical binding]; other site 279010006568 active site 279010006569 catalytic residues [active] 279010006570 heterodimer interface [polypeptide binding]; other site 279010006571 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 279010006572 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 279010006573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010006574 catalytic residue [active] 279010006575 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 279010006576 active site 279010006577 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 279010006578 active site 279010006579 ribulose/triose binding site [chemical binding]; other site 279010006580 phosphate binding site [ion binding]; other site 279010006581 substrate (anthranilate) binding pocket [chemical binding]; other site 279010006582 product (indole) binding pocket [chemical binding]; other site 279010006583 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 279010006584 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010006585 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010006586 anthranilate synthase component I; Provisional; Region: PRK13569 279010006587 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 279010006588 chorismate binding enzyme; Region: Chorismate_bind; cl10555 279010006589 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 279010006590 homotrimer interaction site [polypeptide binding]; other site 279010006591 active site 279010006592 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 279010006593 active site 279010006594 dimer interface [polypeptide binding]; other site 279010006595 metal binding site [ion binding]; metal-binding site 279010006596 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 279010006597 Tetramer interface [polypeptide binding]; other site 279010006598 active site 279010006599 FMN-binding site [chemical binding]; other site 279010006600 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 279010006601 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 279010006602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006603 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 279010006604 active site 279010006605 multimer interface [polypeptide binding]; other site 279010006606 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279010006607 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279010006608 substrate binding pocket [chemical binding]; other site 279010006609 chain length determination region; other site 279010006610 substrate-Mg2+ binding site; other site 279010006611 catalytic residues [active] 279010006612 aspartate-rich region 1; other site 279010006613 active site lid residues [active] 279010006614 aspartate-rich region 2; other site 279010006615 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 279010006616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010006617 S-adenosylmethionine binding site [chemical binding]; other site 279010006618 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 279010006619 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 279010006620 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 279010006621 homodecamer interface [polypeptide binding]; other site 279010006622 GTP cyclohydrolase I; Provisional; Region: PLN03044 279010006623 active site 279010006624 putative catalytic site residues [active] 279010006625 zinc binding site [ion binding]; other site 279010006626 GTP-CH-I/GFRP interaction surface; other site 279010006627 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 279010006628 IHF dimer interface [polypeptide binding]; other site 279010006629 IHF - DNA interface [nucleotide binding]; other site 279010006630 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 279010006631 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 279010006632 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 279010006633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006634 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 279010006635 GTP-binding protein Der; Reviewed; Region: PRK00093 279010006636 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 279010006637 G1 box; other site 279010006638 GTP/Mg2+ binding site [chemical binding]; other site 279010006639 Switch I region; other site 279010006640 G2 box; other site 279010006641 Switch II region; other site 279010006642 G3 box; other site 279010006643 G4 box; other site 279010006644 G5 box; other site 279010006645 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 279010006646 G1 box; other site 279010006647 GTP/Mg2+ binding site [chemical binding]; other site 279010006648 Switch I region; other site 279010006649 G2 box; other site 279010006650 G3 box; other site 279010006651 Switch II region; other site 279010006652 G4 box; other site 279010006653 G5 box; other site 279010006654 YIEGIA protein; Region: YIEGIA; pfam14045 279010006655 YpzI-like protein; Region: YpzI; pfam14140 279010006656 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 279010006657 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 279010006658 homotetramer interface [polypeptide binding]; other site 279010006659 FMN binding site [chemical binding]; other site 279010006660 homodimer contacts [polypeptide binding]; other site 279010006661 putative active site [active] 279010006662 putative substrate binding site [chemical binding]; other site 279010006663 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 279010006664 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 279010006665 RNA binding site [nucleotide binding]; other site 279010006666 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 279010006667 RNA binding site [nucleotide binding]; other site 279010006668 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 279010006669 RNA binding site [nucleotide binding]; other site 279010006670 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 279010006671 RNA binding site [nucleotide binding]; other site 279010006672 cytidylate kinase; Provisional; Region: cmk; PRK00023 279010006673 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 279010006674 CMP-binding site; other site 279010006675 The sites determining sugar specificity; other site 279010006676 germination protein YpeB; Region: spore_YpeB; TIGR02889 279010006677 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010006678 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 279010006679 Protease prsW family; Region: PrsW-protease; cl15823 279010006680 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 279010006681 active site 279010006682 homotetramer interface [polypeptide binding]; other site 279010006683 homodimer interface [polypeptide binding]; other site 279010006684 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 279010006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010006687 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 279010006688 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010006689 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 279010006690 NAD(P) binding site [chemical binding]; other site 279010006691 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 279010006692 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010006693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010006694 putative active site [active] 279010006695 putative metal binding site [ion binding]; other site 279010006696 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 279010006697 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 279010006698 CAAX protease self-immunity; Region: Abi; cl00558 279010006699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010006700 ATP binding site [chemical binding]; other site 279010006701 putative Mg++ binding site [ion binding]; other site 279010006702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010006703 nucleotide binding region [chemical binding]; other site 279010006704 ATP-binding site [chemical binding]; other site 279010006705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 279010006706 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 279010006707 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 279010006708 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 279010006709 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 279010006710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006711 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 279010006712 putative L-serine binding site [chemical binding]; other site 279010006713 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010006714 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006715 putative peptidoglycan binding site; other site 279010006716 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 279010006717 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010006718 putative peptidoglycan binding site; other site 279010006719 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 279010006720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010006721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010006722 DNA binding residues [nucleotide binding] 279010006723 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010006724 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 279010006725 NodB motif; other site 279010006726 active site 279010006727 catalytic site [active] 279010006728 Zn binding site [ion binding]; other site 279010006729 Rogdi leucine zipper containing protein; Region: Rogdi_lz; pfam10259 279010006730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279010006731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010006732 dimerization interface [polypeptide binding]; other site 279010006733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010006734 dimer interface [polypeptide binding]; other site 279010006735 phosphorylation site [posttranslational modification] 279010006736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010006737 ATP binding site [chemical binding]; other site 279010006738 Mg2+ binding site [ion binding]; other site 279010006739 G-X-G motif; other site 279010006740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010006741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010006742 active site 279010006743 phosphorylation site [posttranslational modification] 279010006744 intermolecular recognition site; other site 279010006745 dimerization interface [polypeptide binding]; other site 279010006746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010006747 DNA binding site [nucleotide binding] 279010006748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279010006749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010006750 dimerization interface [polypeptide binding]; other site 279010006751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010006752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010006753 dimer interface [polypeptide binding]; other site 279010006754 phosphorylation site [posttranslational modification] 279010006755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010006756 ATP binding site [chemical binding]; other site 279010006757 Mg2+ binding site [ion binding]; other site 279010006758 G-X-G motif; other site 279010006759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010006761 active site 279010006762 phosphorylation site [posttranslational modification] 279010006763 intermolecular recognition site; other site 279010006764 dimerization interface [polypeptide binding]; other site 279010006765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010006766 DNA binding site [nucleotide binding] 279010006767 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 279010006768 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 279010006769 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 279010006770 ResB-like family; Region: ResB; pfam05140 279010006771 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 279010006772 catalytic residues [active] 279010006773 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279010006774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010006775 RNA binding surface [nucleotide binding]; other site 279010006776 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 279010006777 active site 279010006778 Nucleoside recognition; Region: Gate; cl00486 279010006779 Nucleoside recognition; Region: Gate; cl00486 279010006780 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010006781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010006782 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 279010006783 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 279010006784 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 279010006785 ScpA/B protein; Region: ScpA_ScpB; cl00598 279010006786 Domain of unknown function (DUF309); Region: DUF309; cl00667 279010006787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006788 Coenzyme A binding pocket [chemical binding]; other site 279010006789 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 279010006790 homopentamer interface [polypeptide binding]; other site 279010006791 active site 279010006792 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 279010006793 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 279010006794 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 279010006795 dimerization interface [polypeptide binding]; other site 279010006796 active site 279010006797 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 279010006798 Lumazine binding domain; Region: Lum_binding; pfam00677 279010006799 Lumazine binding domain; Region: Lum_binding; pfam00677 279010006800 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 279010006801 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 279010006802 catalytic motif [active] 279010006803 Zn binding site [ion binding]; other site 279010006804 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 279010006805 Predicted kinase [General function prediction only]; Region: COG4639 279010006806 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 279010006807 active site 279010006808 metal binding site [ion binding]; metal-binding site 279010006809 RNA ligase; Region: RNA_lig_T4_1; cl09743 279010006810 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 279010006811 putative dimer interface [polypeptide binding]; other site 279010006812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010006813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010006814 TPR motif; other site 279010006815 binding surface 279010006816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010006817 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 279010006818 active site 279010006819 Predicted secreted protein [Function unknown]; Region: COG4086 279010006820 Helix-turn-helix domains; Region: HTH; cl00088 279010006821 Helix-turn-helix domains; Region: HTH; cl00088 279010006822 putative transposase OrfB; Reviewed; Region: PHA02517 279010006823 Integrase core domain; Region: rve; cl01316 279010006824 Protein of unknown function (DUF867); Region: DUF867; cl01713 279010006825 diaminopimelate decarboxylase; Region: lysA; TIGR01048 279010006826 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 279010006827 active site 279010006828 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010006829 substrate binding site [chemical binding]; other site 279010006830 catalytic residues [active] 279010006831 dimer interface [polypeptide binding]; other site 279010006832 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010006833 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 279010006834 SpoVA protein; Region: SpoVA; cl04298 279010006835 stage V sporulation protein AD; Validated; Region: PRK08304 279010006836 stage V sporulation protein AD; Provisional; Region: PRK12404 279010006837 SpoVA protein; Region: SpoVA; cl04298 279010006838 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 279010006839 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 279010006840 sporulation sigma factor SigF; Validated; Region: PRK05572 279010006841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010006842 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010006843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010006844 DNA binding residues [nucleotide binding] 279010006845 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279010006846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010006847 ATP binding site [chemical binding]; other site 279010006848 Mg2+ binding site [ion binding]; other site 279010006849 G-X-G motif; other site 279010006850 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 279010006851 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 279010006852 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010006853 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 279010006854 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 279010006855 Sulfatase; Region: Sulfatase; cl10460 279010006856 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 279010006857 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 279010006858 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 279010006859 Int/Topo IB signature motif; other site 279010006860 active site 279010006861 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 279010006862 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010006863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010006864 metal binding site 2 [ion binding]; metal-binding site 279010006865 putative DNA binding helix; other site 279010006866 metal binding site 1 [ion binding]; metal-binding site 279010006867 dimer interface [polypeptide binding]; other site 279010006868 structural Zn2+ binding site [ion binding]; other site 279010006869 Integral membrane protein DUF95; Region: DUF95; cl00572 279010006870 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010006871 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010006872 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010006873 active site 279010006874 P-loop; other site 279010006875 phosphorylation site [posttranslational modification] 279010006876 Sodium:solute symporter family; Region: SSF; cl00456 279010006877 Sodium:solute symporter family; Region: SSF; cl00456 279010006878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010006879 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010006881 Coenzyme A binding pocket [chemical binding]; other site 279010006882 TIGR00375 family protein; Region: TIGR00375 279010006883 PHP-associated; Region: PHP_C; pfam13263 279010006884 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 279010006885 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 279010006886 dimer interface [polypeptide binding]; other site 279010006887 ADP-ribose binding site [chemical binding]; other site 279010006888 active site 279010006889 nudix motif; other site 279010006890 metal binding site [ion binding]; metal-binding site 279010006891 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 279010006892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010006893 Helix-turn-helix domains; Region: HTH; cl00088 279010006894 DoxX; Region: DoxX; cl00976 279010006895 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 279010006896 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010006897 active site 279010006898 catalytic tetrad [active] 279010006899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006900 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 279010006901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006902 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 279010006903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 279010006904 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 279010006905 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010006906 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 279010006907 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 279010006908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006909 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 279010006910 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 279010006911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279010006912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010006913 dimer interface [polypeptide binding]; other site 279010006914 conserved gate region; other site 279010006915 putative PBP binding loops; other site 279010006916 ABC-ATPase subunit interface; other site 279010006917 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010006918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010006919 dimer interface [polypeptide binding]; other site 279010006920 conserved gate region; other site 279010006921 putative PBP binding loops; other site 279010006922 ABC-ATPase subunit interface; other site 279010006923 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010006924 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 279010006925 Walker A/P-loop; other site 279010006926 ATP binding site [chemical binding]; other site 279010006927 Q-loop/lid; other site 279010006928 ABC transporter signature motif; other site 279010006929 Walker B; other site 279010006930 D-loop; other site 279010006931 H-loop/switch region; other site 279010006932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279010006933 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 279010006934 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010006935 Walker A/P-loop; other site 279010006936 ATP binding site [chemical binding]; other site 279010006937 Q-loop/lid; other site 279010006938 ABC transporter signature motif; other site 279010006939 Walker B; other site 279010006940 D-loop; other site 279010006941 H-loop/switch region; other site 279010006942 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 279010006943 MatE; Region: MatE; cl10513 279010006944 MatE; Region: MatE; cl10513 279010006945 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 279010006946 YolD-like protein; Region: YolD; pfam08863 279010006947 DNA polymerase IV; Reviewed; Region: PRK03103 279010006948 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 279010006949 active site 279010006950 DNA binding site [nucleotide binding] 279010006951 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 279010006952 YqzH-like protein; Region: YqzH; pfam14164 279010006953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010006954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010006955 putative substrate translocation pore; other site 279010006956 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 279010006957 putative dimer interface [polypeptide binding]; other site 279010006958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010006959 ligand binding site [chemical binding]; other site 279010006960 Zn binding site [ion binding]; other site 279010006961 pantothenate kinase; Provisional; Region: PRK05439 279010006962 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 279010006963 ATP-binding site [chemical binding]; other site 279010006964 CoA-binding site [chemical binding]; other site 279010006965 Mg2+-binding site [ion binding]; other site 279010006966 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279010006967 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010006968 Walker A/P-loop; other site 279010006969 ATP binding site [chemical binding]; other site 279010006970 Q-loop/lid; other site 279010006971 ABC transporter signature motif; other site 279010006972 Walker B; other site 279010006973 D-loop; other site 279010006974 H-loop/switch region; other site 279010006975 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 279010006976 Protein of unknown function (DUF867); Region: DUF867; cl01713 279010006977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006978 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 279010006979 NAD(P) binding site [chemical binding]; other site 279010006980 active site 279010006981 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 279010006982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010006983 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 279010006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010006985 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 279010006986 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 279010006987 putative metal binding site [ion binding]; other site 279010006988 putative dimer interface [polypeptide binding]; other site 279010006989 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 279010006990 active site 279010006991 FMN binding site [chemical binding]; other site 279010006992 substrate binding site [chemical binding]; other site 279010006993 homotetramer interface [polypeptide binding]; other site 279010006994 catalytic residue [active] 279010006995 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010006996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010006997 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 279010006998 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010006999 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 279010007000 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 279010007001 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 279010007002 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 279010007003 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 279010007004 NMT1-like family; Region: NMT1_2; cl15260 279010007005 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010007006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010007007 DNA-binding site [nucleotide binding]; DNA binding site 279010007008 UTRA domain; Region: UTRA; cl01230 279010007009 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010007010 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010007011 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010007012 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 279010007013 active site 279010007014 methionine cluster; other site 279010007015 phosphorylation site [posttranslational modification] 279010007016 metal binding site [ion binding]; metal-binding site 279010007017 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010007018 active site 279010007019 P-loop; other site 279010007020 phosphorylation site [posttranslational modification] 279010007021 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 279010007022 dimer interface [polypeptide binding]; other site 279010007023 Alkaline phosphatase homologues; Region: alkPPc; smart00098 279010007024 active site 279010007025 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 279010007026 glucose-1-dehydrogenase; Provisional; Region: PRK08936 279010007027 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 279010007028 NAD binding site [chemical binding]; other site 279010007029 homodimer interface [polypeptide binding]; other site 279010007030 active site 279010007031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007032 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 279010007033 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 279010007034 DNA polymerase IV; Validated; Region: PRK01810 279010007035 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 279010007036 active site 279010007037 DNA binding site [nucleotide binding] 279010007038 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 279010007039 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 279010007040 peptidase T-like protein; Region: PepT-like; TIGR01883 279010007041 metal binding site [ion binding]; metal-binding site 279010007042 putative dimer interface [polypeptide binding]; other site 279010007043 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 279010007044 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010007045 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010007046 Predicted membrane protein [Function unknown]; Region: COG4129 279010007047 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 279010007048 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 279010007049 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279010007050 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 279010007051 Walker A/P-loop; other site 279010007052 ATP binding site [chemical binding]; other site 279010007053 Q-loop/lid; other site 279010007054 ABC transporter signature motif; other site 279010007055 Walker B; other site 279010007056 D-loop; other site 279010007057 H-loop/switch region; other site 279010007058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007059 dimer interface [polypeptide binding]; other site 279010007060 conserved gate region; other site 279010007061 putative PBP binding loops; other site 279010007062 ABC-ATPase subunit interface; other site 279010007063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 279010007064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279010007065 substrate binding pocket [chemical binding]; other site 279010007066 membrane-bound complex binding site; other site 279010007067 Disulphide isomerase; Region: Disulph_isomer; pfam06491 279010007068 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 279010007069 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 279010007070 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279010007071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279010007072 E3 interaction surface; other site 279010007073 lipoyl attachment site [posttranslational modification]; other site 279010007074 e3 binding domain; Region: E3_binding; pfam02817 279010007075 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 279010007076 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279010007077 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279010007078 alpha subunit interface [polypeptide binding]; other site 279010007079 TPP binding site [chemical binding]; other site 279010007080 heterodimer interface [polypeptide binding]; other site 279010007081 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010007082 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 279010007083 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279010007084 tetramer interface [polypeptide binding]; other site 279010007085 TPP-binding site [chemical binding]; other site 279010007086 heterodimer interface [polypeptide binding]; other site 279010007087 phosphorylation loop region [posttranslational modification] 279010007088 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 279010007089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010007091 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279010007092 Acetokinase family; Region: Acetate_kinase; cl01029 279010007093 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 279010007094 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010007095 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 279010007096 NAD binding site [chemical binding]; other site 279010007097 Phe binding site; other site 279010007098 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 279010007099 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 279010007100 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 279010007101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010007102 putative active site [active] 279010007103 heme pocket [chemical binding]; other site 279010007104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010007105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010007106 Walker A motif; other site 279010007107 ATP binding site [chemical binding]; other site 279010007108 Walker B motif; other site 279010007109 arginine finger; other site 279010007110 Helix-turn-helix domains; Region: HTH; cl00088 279010007111 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 279010007112 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 279010007113 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 279010007114 active site 279010007115 catalytic site [active] 279010007116 metal binding site [ion binding]; metal-binding site 279010007117 dimer interface [polypeptide binding]; other site 279010007118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010007119 active site 279010007120 metal binding site [ion binding]; metal-binding site 279010007121 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 279010007122 active site 279010007123 substrate binding site [chemical binding]; other site 279010007124 trimer interface [polypeptide binding]; other site 279010007125 CoA binding site [chemical binding]; other site 279010007126 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 279010007127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007128 active site 279010007129 phosphorylation site [posttranslational modification] 279010007130 intermolecular recognition site; other site 279010007131 dimerization interface [polypeptide binding]; other site 279010007132 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 279010007133 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 279010007134 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 279010007135 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 279010007136 DNA repair protein RecN; Region: recN; TIGR00634 279010007137 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 279010007138 Walker A/P-loop; other site 279010007139 ATP binding site [chemical binding]; other site 279010007140 Q-loop/lid; other site 279010007141 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 279010007142 ABC transporter signature motif; other site 279010007143 Walker B; other site 279010007144 D-loop; other site 279010007145 H-loop/switch region; other site 279010007146 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279010007147 arginine repressor; Provisional; Region: PRK04280 279010007148 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279010007149 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 279010007150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010007151 RNA binding surface [nucleotide binding]; other site 279010007152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 279010007153 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 279010007154 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 279010007155 TPP-binding site; other site 279010007156 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279010007157 PYR/PP interface [polypeptide binding]; other site 279010007158 dimer interface [polypeptide binding]; other site 279010007159 TPP binding site [chemical binding]; other site 279010007160 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279010007161 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279010007162 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279010007163 substrate binding pocket [chemical binding]; other site 279010007164 chain length determination region; other site 279010007165 substrate-Mg2+ binding site; other site 279010007166 catalytic residues [active] 279010007167 aspartate-rich region 1; other site 279010007168 active site lid residues [active] 279010007169 aspartate-rich region 2; other site 279010007170 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 279010007171 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 279010007172 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 279010007173 generic binding surface II; other site 279010007174 generic binding surface I; other site 279010007175 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 279010007176 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 279010007177 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 279010007178 homodimer interface [polypeptide binding]; other site 279010007179 NADP binding site [chemical binding]; other site 279010007180 substrate binding site [chemical binding]; other site 279010007181 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 279010007182 putative RNA binding site [nucleotide binding]; other site 279010007183 Asp23 family; Region: Asp23; cl00574 279010007184 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 279010007185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279010007186 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010007187 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 279010007188 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 279010007189 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279010007190 carboxyltransferase (CT) interaction site; other site 279010007191 biotinylation site [posttranslational modification]; other site 279010007192 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 279010007193 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 279010007194 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 279010007195 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 279010007196 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 279010007197 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 279010007198 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 279010007199 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 279010007200 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 279010007201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010007202 Walker A motif; other site 279010007203 ATP binding site [chemical binding]; other site 279010007204 Walker B motif; other site 279010007205 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 279010007206 elongation factor P; Validated; Region: PRK00529 279010007207 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 279010007208 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 279010007209 RNA binding site [nucleotide binding]; other site 279010007210 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 279010007211 RNA binding site [nucleotide binding]; other site 279010007212 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279010007213 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279010007214 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279010007215 active site 279010007216 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 279010007217 trimer interface [polypeptide binding]; other site 279010007218 active site 279010007219 dimer interface [polypeptide binding]; other site 279010007220 Conserved membrane protein YqhR; Region: YqhR; pfam11085 279010007221 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 279010007222 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 279010007223 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 279010007224 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 279010007225 active site 279010007226 nucleophile elbow; other site 279010007227 manganese transport transcriptional regulator; Provisional; Region: PRK03902 279010007228 Helix-turn-helix domains; Region: HTH; cl00088 279010007229 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 279010007230 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279010007231 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 279010007232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010007233 active site residue [active] 279010007234 NMT1-like family; Region: NMT1_2; cl15260 279010007235 NMT1-like family; Region: NMT1_2; cl15260 279010007236 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 279010007237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007238 dimer interface [polypeptide binding]; other site 279010007239 conserved gate region; other site 279010007240 putative PBP binding loops; other site 279010007241 ABC-ATPase subunit interface; other site 279010007242 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 279010007243 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 279010007244 Walker A/P-loop; other site 279010007245 ATP binding site [chemical binding]; other site 279010007246 Q-loop/lid; other site 279010007247 ABC transporter signature motif; other site 279010007248 Walker B; other site 279010007249 D-loop; other site 279010007250 H-loop/switch region; other site 279010007251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 279010007252 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 279010007253 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279010007254 tetramer interface [polypeptide binding]; other site 279010007255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007256 catalytic residue [active] 279010007257 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 279010007258 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279010007259 tetramer interface [polypeptide binding]; other site 279010007260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007261 catalytic residue [active] 279010007262 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 279010007263 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 279010007264 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 279010007265 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010007266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010007267 ATP binding site [chemical binding]; other site 279010007268 putative Mg++ binding site [ion binding]; other site 279010007269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010007270 nucleotide binding region [chemical binding]; other site 279010007271 ATP-binding site [chemical binding]; other site 279010007272 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 279010007273 Anti-repressor SinI; Region: SinI; pfam08671 279010007274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010007275 non-specific DNA binding site [nucleotide binding]; other site 279010007276 salt bridge; other site 279010007277 sequence-specific DNA binding site [nucleotide binding]; other site 279010007278 Anti-repressor SinI; Region: SinI; pfam08671 279010007279 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 279010007280 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279010007281 Catalytic site [active] 279010007282 YqxM protein; Region: YqxM_for_SipW; TIGR04087 279010007283 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 279010007284 YqzE-like protein; Region: YqzE; pfam14038 279010007285 ComG operon protein 7; Region: ComGG; pfam14173 279010007286 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 279010007287 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 279010007288 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 279010007289 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 279010007290 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 279010007291 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 279010007292 Type II/IV secretion system protein; Region: T2SE; pfam00437 279010007293 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 279010007294 Walker A motif; other site 279010007295 ATP binding site [chemical binding]; other site 279010007296 Walker B motif; other site 279010007297 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 279010007298 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 279010007299 ArsC family; Region: ArsC; pfam03960 279010007300 putative catalytic residues [active] 279010007301 thiol/disulfide switch; other site 279010007302 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 279010007303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010007304 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 279010007305 Domain of unknown function DUF77; Region: DUF77; cl00307 279010007306 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 279010007307 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 279010007308 putative active site [active] 279010007309 Zn binding site [ion binding]; other site 279010007310 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 279010007311 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279010007312 putative ligand binding residues [chemical binding]; other site 279010007313 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010007314 Sulfatase; Region: Sulfatase; cl10460 279010007315 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 279010007316 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 279010007317 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 279010007318 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010007319 Rhomboid family; Region: Rhomboid; cl11446 279010007320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010007321 binding surface 279010007322 TPR motif; other site 279010007323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 279010007324 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 279010007325 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 279010007326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010007327 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 279010007328 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 279010007329 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 279010007330 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 279010007331 Walker A/P-loop; other site 279010007332 ATP binding site [chemical binding]; other site 279010007333 Q-loop/lid; other site 279010007334 ABC transporter signature motif; other site 279010007335 Walker B; other site 279010007336 D-loop; other site 279010007337 H-loop/switch region; other site 279010007338 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 279010007339 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 279010007340 Walker A/P-loop; other site 279010007341 ATP binding site [chemical binding]; other site 279010007342 Q-loop/lid; other site 279010007343 ABC transporter signature motif; other site 279010007344 Walker B; other site 279010007345 D-loop; other site 279010007346 H-loop/switch region; other site 279010007347 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 279010007348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007349 dimer interface [polypeptide binding]; other site 279010007350 conserved gate region; other site 279010007351 ABC-ATPase subunit interface; other site 279010007352 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 279010007353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007354 dimer interface [polypeptide binding]; other site 279010007355 conserved gate region; other site 279010007356 putative PBP binding loops; other site 279010007357 ABC-ATPase subunit interface; other site 279010007358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010007359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 279010007360 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010007361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010007362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010007363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007364 putative substrate translocation pore; other site 279010007365 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 279010007366 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 279010007367 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 279010007368 Protein of unknown function (DUF456); Region: DUF456; cl01069 279010007369 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 279010007370 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 279010007371 putative peptidoglycan binding site; other site 279010007372 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 279010007373 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 279010007374 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 279010007375 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 279010007376 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010007377 ferric uptake regulator; Provisional; Region: fur; PRK09462 279010007378 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010007379 metal binding site 2 [ion binding]; metal-binding site 279010007380 putative DNA binding helix; other site 279010007381 metal binding site 1 [ion binding]; metal-binding site 279010007382 dimer interface [polypeptide binding]; other site 279010007383 structural Zn2+ binding site [ion binding]; other site 279010007384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010007385 ABC-ATPase subunit interface; other site 279010007386 dimer interface [polypeptide binding]; other site 279010007387 putative PBP binding regions; other site 279010007388 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279010007389 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 279010007390 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010007391 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010007392 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010007393 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010007394 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 279010007395 endonuclease IV; Provisional; Region: PRK01060 279010007396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 279010007397 AP (apurinic/apyrimidinic) site pocket; other site 279010007398 DNA interaction; other site 279010007399 Metal-binding active site; metal-binding site 279010007400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010007401 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279010007402 ATP binding site [chemical binding]; other site 279010007403 Mg++ binding site [ion binding]; other site 279010007404 motif III; other site 279010007405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010007406 nucleotide binding region [chemical binding]; other site 279010007407 ATP-binding site [chemical binding]; other site 279010007408 YqfQ-like protein; Region: YqfQ; pfam14181 279010007409 LytB protein; Region: LYTB; cl00507 279010007410 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 279010007411 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 279010007412 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 279010007413 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 279010007414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007415 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 279010007416 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 279010007417 Active_site [active] 279010007418 Uncharacterized conserved protein [Function unknown]; Region: COG5444 279010007419 Immunity protein Imm6; Region: Imm6; pfam14434 279010007420 Immunity protein Imm6; Region: Imm6; pfam14434 279010007421 Uncharacterized conserved protein [Function unknown]; Region: COG5444 279010007422 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010007423 Cytochrome c; Region: Cytochrom_C; cl11414 279010007424 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 279010007425 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 279010007426 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 279010007427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007428 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279010007429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007430 DNA binding residues [nucleotide binding] 279010007431 DNA primase; Validated; Region: dnaG; PRK05667 279010007432 CHC2 zinc finger; Region: zf-CHC2; cl15369 279010007433 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 279010007434 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 279010007435 active site 279010007436 metal binding site [ion binding]; metal-binding site 279010007437 interdomain interaction site; other site 279010007438 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 279010007439 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 279010007440 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 279010007441 Helix-turn-helix domains; Region: HTH; cl00088 279010007442 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 279010007443 FOG: CBS domain [General function prediction only]; Region: COG0517 279010007444 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 279010007445 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 279010007446 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 279010007447 dimer interface [polypeptide binding]; other site 279010007448 motif 1; other site 279010007449 active site 279010007450 motif 2; other site 279010007451 motif 3; other site 279010007452 Recombination protein O N terminal; Region: RecO_N; cl15812 279010007453 DNA repair protein RecO; Region: reco; TIGR00613 279010007454 Recombination protein O C terminal; Region: RecO_C; pfam02565 279010007455 GTPase Era; Reviewed; Region: era; PRK00089 279010007456 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 279010007457 G1 box; other site 279010007458 GTP/Mg2+ binding site [chemical binding]; other site 279010007459 Switch I region; other site 279010007460 G2 box; other site 279010007461 Switch II region; other site 279010007462 G3 box; other site 279010007463 G4 box; other site 279010007464 G5 box; other site 279010007465 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 279010007466 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 279010007467 active site 279010007468 catalytic motif [active] 279010007469 Zn binding site [ion binding]; other site 279010007470 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 279010007471 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 279010007472 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 279010007473 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 279010007474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010007475 Zn2+ binding site [ion binding]; other site 279010007476 Mg2+ binding site [ion binding]; other site 279010007477 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 279010007478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010007479 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 279010007480 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 279010007481 YabP family; Region: YabP; cl06766 279010007482 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 279010007483 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 279010007484 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 279010007485 dimer interface [polypeptide binding]; other site 279010007486 active site residues [active] 279010007487 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 279010007488 GatB domain; Region: GatB_Yqey; cl11497 279010007489 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 279010007490 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 279010007491 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010007492 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 279010007493 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 279010007494 intersubunit interface [polypeptide binding]; other site 279010007495 active site 279010007496 catalytic residue [active] 279010007497 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 279010007498 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279010007499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010007500 FeS/SAM binding site; other site 279010007501 TRAM domain; Region: TRAM; cl01282 279010007502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 279010007503 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 279010007504 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 279010007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007506 S-adenosylmethionine binding site [chemical binding]; other site 279010007507 chaperone protein DnaJ; Provisional; Region: PRK14280 279010007508 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 279010007509 HSP70 interaction site [polypeptide binding]; other site 279010007510 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 279010007511 substrate binding site [polypeptide binding]; other site 279010007512 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 279010007513 Zn binding sites [ion binding]; other site 279010007514 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 279010007515 dimer interface [polypeptide binding]; other site 279010007516 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 279010007517 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 279010007518 dimer interface [polypeptide binding]; other site 279010007519 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 279010007520 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 279010007521 Helix-turn-helix domains; Region: HTH; cl00088 279010007522 HrcA protein C terminal domain; Region: HrcA; pfam01628 279010007523 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 279010007524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010007525 FeS/SAM binding site; other site 279010007526 HemN C-terminal domain; Region: HemN_C; pfam06969 279010007527 GTP-binding protein LepA; Provisional; Region: PRK05433 279010007528 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 279010007529 G1 box; other site 279010007530 putative GEF interaction site [polypeptide binding]; other site 279010007531 GTP/Mg2+ binding site [chemical binding]; other site 279010007532 Switch I region; other site 279010007533 G2 box; other site 279010007534 G3 box; other site 279010007535 Switch II region; other site 279010007536 G4 box; other site 279010007537 G5 box; other site 279010007538 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 279010007539 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 279010007540 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 279010007541 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 279010007542 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 279010007543 stage II sporulation protein P; Region: spore_II_P; TIGR02867 279010007544 Germination protease; Region: Peptidase_A25; cl04057 279010007545 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 279010007546 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 279010007547 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 279010007548 YqzM-like protein; Region: YqzM; pfam14141 279010007549 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 279010007550 Competence protein; Region: Competence; cl00471 279010007551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010007552 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 279010007553 catalytic motif [active] 279010007554 Zn binding site [ion binding]; other site 279010007555 SLBB domain; Region: SLBB; pfam10531 279010007556 comEA protein; Region: comE; TIGR01259 279010007557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 279010007558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007559 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279010007560 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 279010007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007562 S-adenosylmethionine binding site [chemical binding]; other site 279010007563 Oligomerisation domain; Region: Oligomerisation; cl00519 279010007564 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 279010007565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279010007566 Zn2+ binding site [ion binding]; other site 279010007567 Mg2+ binding site [ion binding]; other site 279010007568 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 279010007569 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 279010007570 active site 279010007571 (T/H)XGH motif; other site 279010007572 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 279010007573 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 279010007574 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 279010007575 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 279010007576 shikimate binding site; other site 279010007577 NAD(P) binding site [chemical binding]; other site 279010007578 GTPase YqeH; Provisional; Region: PRK13796 279010007579 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 279010007580 GTP/Mg2+ binding site [chemical binding]; other site 279010007581 G4 box; other site 279010007582 G5 box; other site 279010007583 G1 box; other site 279010007584 Switch I region; other site 279010007585 G2 box; other site 279010007586 G3 box; other site 279010007587 Switch II region; other site 279010007588 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 279010007589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010007590 active site 279010007591 motif I; other site 279010007592 motif II; other site 279010007593 Sporulation inhibitor A; Region: Sda; pfam08970 279010007594 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 279010007595 active site 279010007596 catalytic triad [active] 279010007597 oxyanion hole [active] 279010007598 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010007599 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 279010007600 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 279010007601 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 279010007602 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 279010007603 4Fe-4S binding domain; Region: Fer4; cl02805 279010007604 4Fe-4S binding domain; Region: Fer4; cl02805 279010007605 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 279010007606 [4Fe-4S] binding site [ion binding]; other site 279010007607 molybdopterin cofactor binding site; other site 279010007608 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 279010007609 molybdopterin cofactor binding site; other site 279010007610 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 279010007611 sporulation sigma factor SigK; Reviewed; Region: PRK05803 279010007612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010007613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010007614 DNA binding residues [nucleotide binding] 279010007615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007616 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010007617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010007618 Coenzyme A binding pocket [chemical binding]; other site 279010007619 sporulation sigma factor SigK; Reviewed; Region: PRK05803 279010007620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010007621 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 279010007622 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 279010007623 DHHA1 domain; Region: DHHA1; pfam02272 279010007624 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 279010007625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 279010007626 dimer interface [polypeptide binding]; other site 279010007627 active site 279010007628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010007629 substrate binding site [chemical binding]; other site 279010007630 catalytic residue [active] 279010007631 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010007632 homotrimer interaction site [polypeptide binding]; other site 279010007633 putative active site [active] 279010007634 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 279010007635 active site 279010007636 homodimer interface [polypeptide binding]; other site 279010007637 homotetramer interface [polypeptide binding]; other site 279010007638 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 279010007639 threonine synthase; Validated; Region: PRK06260 279010007640 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 279010007641 homodimer interface [polypeptide binding]; other site 279010007642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007643 catalytic residue [active] 279010007644 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279010007645 homotrimer interaction site [polypeptide binding]; other site 279010007646 putative active site [active] 279010007647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 279010007648 YheO-like PAS domain; Region: PAS_6; pfam08348 279010007649 Helix-turn-helix domains; Region: HTH; cl00088 279010007650 sporulation sigma factor SigK; Reviewed; Region: PRK05803 279010007651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010007652 Flavin Reductases; Region: FlaRed; cl00801 279010007653 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010007654 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 279010007655 DNA binding residues [nucleotide binding] 279010007656 drug binding residues [chemical binding]; other site 279010007657 dimer interface [polypeptide binding]; other site 279010007658 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010007659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010007660 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010007661 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010007662 active site residue [active] 279010007663 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 279010007664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010007666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007667 active site 279010007668 phosphorylation site [posttranslational modification] 279010007669 intermolecular recognition site; other site 279010007670 dimerization interface [polypeptide binding]; other site 279010007671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010007672 DNA binding residues [nucleotide binding] 279010007673 dimerization interface [polypeptide binding]; other site 279010007674 PAS domain S-box; Region: sensory_box; TIGR00229 279010007675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010007676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010007677 Histidine kinase; Region: HisKA_3; pfam07730 279010007678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010007679 ATP binding site [chemical binding]; other site 279010007680 Mg2+ binding site [ion binding]; other site 279010007681 G-X-G motif; other site 279010007682 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010007683 catalytic residues [active] 279010007684 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 279010007685 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279010007686 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 279010007687 CPxP motif; other site 279010007688 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 279010007689 active site residue [active] 279010007690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010007691 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 279010007692 CPxP motif; other site 279010007693 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010007694 active site residue [active] 279010007695 DsrE/DsrF-like family; Region: DrsE; cl00672 279010007696 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 279010007697 putative homotetramer interface [polypeptide binding]; other site 279010007698 putative homodimer interface [polypeptide binding]; other site 279010007699 putative metal binding site [ion binding]; other site 279010007700 putative homodimer-homodimer interface [polypeptide binding]; other site 279010007701 putative allosteric switch controlling residues; other site 279010007702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007703 S-adenosylmethionine binding site [chemical binding]; other site 279010007704 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 279010007705 A new structural DNA glycosylase; Region: AlkD_like; cd06561 279010007706 active site 279010007707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 279010007708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 279010007709 ABC-ATPase subunit interface; other site 279010007710 Domain of unknown function (DUF303); Region: DUF303; pfam03629 279010007711 Haemolytic domain; Region: Haemolytic; cl00506 279010007712 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 279010007713 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 279010007714 tetramer interface [polypeptide binding]; other site 279010007715 active site 279010007716 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 279010007717 active site 279010007718 dimer interface [polypeptide binding]; other site 279010007719 magnesium binding site [ion binding]; other site 279010007720 Helix-turn-helix domains; Region: HTH; cl00088 279010007721 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 279010007722 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 279010007723 putative di-iron ligands [ion binding]; other site 279010007724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010007725 Histidine kinase; Region: HisKA_3; pfam07730 279010007726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 279010007727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010007728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010007729 active site 279010007730 phosphorylation site [posttranslational modification] 279010007731 intermolecular recognition site; other site 279010007732 dimerization interface [polypeptide binding]; other site 279010007733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010007734 DNA binding residues [nucleotide binding] 279010007735 dimerization interface [polypeptide binding]; other site 279010007736 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010007737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010007738 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279010007739 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 279010007740 substrate binding site [chemical binding]; other site 279010007741 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 279010007742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007743 dimer interface [polypeptide binding]; other site 279010007744 conserved gate region; other site 279010007745 putative PBP binding loops; other site 279010007746 ABC-ATPase subunit interface; other site 279010007747 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 279010007748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010007749 dimer interface [polypeptide binding]; other site 279010007750 conserved gate region; other site 279010007751 putative PBP binding loops; other site 279010007752 ABC-ATPase subunit interface; other site 279010007753 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010007754 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 279010007755 Walker A/P-loop; other site 279010007756 ATP binding site [chemical binding]; other site 279010007757 Q-loop/lid; other site 279010007758 ABC transporter signature motif; other site 279010007759 Walker B; other site 279010007760 D-loop; other site 279010007761 H-loop/switch region; other site 279010007762 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 279010007763 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 279010007764 Walker A/P-loop; other site 279010007765 ATP binding site [chemical binding]; other site 279010007766 Q-loop/lid; other site 279010007767 ABC transporter signature motif; other site 279010007768 Walker B; other site 279010007769 D-loop; other site 279010007770 H-loop/switch region; other site 279010007771 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279010007772 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 279010007773 DNA binding residues [nucleotide binding] 279010007774 drug binding residues [chemical binding]; other site 279010007775 dimer interface [polypeptide binding]; other site 279010007776 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010007777 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 279010007778 MatE; Region: MatE; cl10513 279010007779 MatE; Region: MatE; cl10513 279010007780 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 279010007781 Helix-turn-helix domain; Region: HTH_18; pfam12833 279010007782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010007783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010007784 classical (c) SDRs; Region: SDR_c; cd05233 279010007785 NAD(P) binding site [chemical binding]; other site 279010007786 active site 279010007787 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 279010007788 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279010007789 active site 279010007790 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 279010007791 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 279010007792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010007793 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010007794 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010007795 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 279010007796 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279010007797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010007798 classical (c) SDRs; Region: SDR_c; cd05233 279010007799 NAD(P) binding site [chemical binding]; other site 279010007800 active site 279010007801 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 279010007802 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010007803 substrate binding [chemical binding]; other site 279010007804 active site 279010007805 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010007806 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 279010007807 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 279010007808 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 279010007809 active site 279010007810 phosphorylation site [posttranslational modification] 279010007811 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 279010007812 active pocket/dimerization site; other site 279010007813 active site 279010007814 phosphorylation site [posttranslational modification] 279010007815 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 279010007816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010007817 ATP binding site [chemical binding]; other site 279010007818 Walker A motif; other site 279010007819 Walker B motif; other site 279010007820 arginine finger; other site 279010007821 Transcriptional antiterminator [Transcription]; Region: COG3933 279010007822 PRD domain; Region: PRD; cl15445 279010007823 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 279010007824 active pocket/dimerization site; other site 279010007825 active site 279010007826 phosphorylation site [posttranslational modification] 279010007827 PRD domain; Region: PRD; cl15445 279010007828 YrhK-like protein; Region: YrhK; pfam14145 279010007829 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 279010007830 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 279010007831 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 279010007832 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 279010007833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010007834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010007835 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 279010007836 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 279010007837 DNA binding site [nucleotide binding] 279010007838 active site 279010007839 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010007840 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010007841 active site 279010007842 catalytic tetrad [active] 279010007843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007844 putative substrate translocation pore; other site 279010007845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010007846 Helix-turn-helix domains; Region: HTH; cl00088 279010007847 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 279010007848 active site pocket [active] 279010007849 oxyanion hole [active] 279010007850 catalytic triad [active] 279010007851 active site nucleophile [active] 279010007852 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 279010007853 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 279010007854 active site 279010007855 Cupin domain; Region: Cupin_2; cl09118 279010007856 Cupin domain; Region: Cupin_2; cl09118 279010007857 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010007858 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 279010007859 putative ligand binding residues [chemical binding]; other site 279010007860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010007861 Helix-turn-helix domains; Region: HTH; cl00088 279010007862 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 279010007863 putative dimerization interface [polypeptide binding]; other site 279010007864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010007865 putative substrate translocation pore; other site 279010007866 YoqO-like protein; Region: YoqO; pfam14037 279010007867 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010007868 Cytochrome P450; Region: p450; pfam00067 279010007869 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 279010007870 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010007871 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 279010007872 FAD binding pocket [chemical binding]; other site 279010007873 FAD binding motif [chemical binding]; other site 279010007874 catalytic residues [active] 279010007875 NAD binding pocket [chemical binding]; other site 279010007876 phosphate binding motif [ion binding]; other site 279010007877 beta-alpha-beta structure motif; other site 279010007878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010007879 Helix-turn-helix domains; Region: HTH; cl00088 279010007880 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 279010007881 active site 279010007882 catalytic triad [active] 279010007883 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 279010007884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007885 S-adenosylmethionine binding site [chemical binding]; other site 279010007886 YrhC-like protein; Region: YrhC; pfam14143 279010007887 cystathionine beta-lyase; Provisional; Region: PRK07671 279010007888 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279010007889 homodimer interface [polypeptide binding]; other site 279010007890 substrate-cofactor binding pocket; other site 279010007891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007892 catalytic residue [active] 279010007893 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279010007894 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010007895 dimer interface [polypeptide binding]; other site 279010007896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010007897 catalytic residue [active] 279010007898 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 279010007899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279010007900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007901 S-adenosylmethionine binding site [chemical binding]; other site 279010007902 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 279010007903 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 279010007904 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279010007905 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279010007906 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010007907 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 279010007908 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 279010007909 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 279010007910 ATP-binding site [chemical binding]; other site 279010007911 Sugar specificity; other site 279010007912 Pyrimidine base specificity; other site 279010007913 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 279010007914 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 279010007915 Peptidase family U32; Region: Peptidase_U32; cl03113 279010007916 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 279010007917 Peptidase family U32; Region: Peptidase_U32; cl03113 279010007918 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 279010007919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010007920 S-adenosylmethionine binding site [chemical binding]; other site 279010007921 YceG-like family; Region: YceG; pfam02618 279010007922 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 279010007923 dimerization interface [polypeptide binding]; other site 279010007924 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 279010007925 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 279010007926 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 279010007927 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 279010007928 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 279010007929 motif 1; other site 279010007930 active site 279010007931 motif 2; other site 279010007932 motif 3; other site 279010007933 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 279010007934 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010007935 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 279010007936 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 279010007937 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 279010007938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010007939 Family description; Region: UvrD_C_2; cl15862 279010007940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010007941 binding surface 279010007942 TPR repeat; Region: TPR_11; pfam13414 279010007943 TPR motif; other site 279010007944 TPR repeat; Region: TPR_11; pfam13414 279010007945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010007946 binding surface 279010007947 TPR motif; other site 279010007948 TPR repeat; Region: TPR_11; pfam13414 279010007949 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 279010007950 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 279010007951 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010007952 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 279010007953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010007954 catalytic residue [active] 279010007955 Predicted transcriptional regulator [Transcription]; Region: COG1959 279010007956 Helix-turn-helix domains; Region: HTH; cl00088 279010007957 recombination factor protein RarA; Reviewed; Region: PRK13342 279010007958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010007959 Walker A motif; other site 279010007960 ATP binding site [chemical binding]; other site 279010007961 Walker B motif; other site 279010007962 arginine finger; other site 279010007963 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 279010007964 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 279010007965 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 279010007966 putative ATP binding site [chemical binding]; other site 279010007967 putative substrate interface [chemical binding]; other site 279010007968 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 279010007969 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 279010007970 dimer interface [polypeptide binding]; other site 279010007971 anticodon binding site; other site 279010007972 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 279010007973 homodimer interface [polypeptide binding]; other site 279010007974 motif 1; other site 279010007975 active site 279010007976 motif 2; other site 279010007977 GAD domain; Region: GAD; pfam02938 279010007978 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 279010007979 motif 3; other site 279010007980 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 279010007981 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 279010007982 dimer interface [polypeptide binding]; other site 279010007983 motif 1; other site 279010007984 active site 279010007985 motif 2; other site 279010007986 motif 3; other site 279010007987 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 279010007988 anticodon binding site; other site 279010007989 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 279010007990 Bacterial SH3 domain; Region: SH3_3; cl02551 279010007991 Bacterial SH3 domain; Region: SH3_3; cl02551 279010007992 Bacterial SH3 domain; Region: SH3_3; cl02551 279010007993 Bacterial SH3 domain; Region: SH3_3; cl02551 279010007994 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279010007995 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010007996 active site 279010007997 metal binding site [ion binding]; metal-binding site 279010007998 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 279010007999 putative active site [active] 279010008000 dimerization interface [polypeptide binding]; other site 279010008001 putative tRNAtyr binding site [nucleotide binding]; other site 279010008002 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 279010008003 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010008004 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010008005 synthetase active site [active] 279010008006 NTP binding site [chemical binding]; other site 279010008007 metal binding site [ion binding]; metal-binding site 279010008008 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 279010008009 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 279010008010 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 279010008011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010008012 active site 279010008013 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 279010008014 DHH family; Region: DHH; pfam01368 279010008015 DHHA1 domain; Region: DHHA1; pfam02272 279010008016 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 279010008017 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 279010008018 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 279010008019 Protein export membrane protein; Region: SecD_SecF; cl14618 279010008020 Protein export membrane protein; Region: SecD_SecF; cl14618 279010008021 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 279010008022 stage V sporulation protein B; Region: spore_V_B; TIGR02900 279010008023 MatE; Region: MatE; cl10513 279010008024 MatE; Region: MatE; cl10513 279010008025 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010008026 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 279010008027 Preprotein translocase subunit; Region: YajC; cl00806 279010008028 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 279010008029 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 279010008030 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 279010008031 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 279010008032 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 279010008033 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 279010008034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008035 Walker A motif; other site 279010008036 ATP binding site [chemical binding]; other site 279010008037 Walker B motif; other site 279010008038 arginine finger; other site 279010008039 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 279010008040 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 279010008041 RuvA N terminal domain; Region: RuvA_N; pfam01330 279010008042 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 279010008043 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 279010008044 BofC C-terminal domain; Region: BofC_C; pfam08955 279010008045 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008046 active site 279010008047 ATP binding site [chemical binding]; other site 279010008048 substrate binding site [chemical binding]; other site 279010008049 Small acid-soluble spore protein H family; Region: SspH; cl06949 279010008050 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010008051 DinB superfamily; Region: DinB_2; pfam12867 279010008052 Protein of unknown function (DUF867); Region: DUF867; cl01713 279010008053 Transcriptional regulator; Region: Transcrip_reg; cl00361 279010008054 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010008055 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010008056 putative peptidoglycan binding site; other site 279010008057 Quinolinate synthetase A protein; Region: NadA; cl00420 279010008058 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 279010008059 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 279010008060 dimerization interface [polypeptide binding]; other site 279010008061 active site 279010008062 L-aspartate oxidase; Provisional; Region: PRK08071 279010008063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008064 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 279010008065 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010008066 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 279010008067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010008068 catalytic residue [active] 279010008069 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 279010008070 Helix-turn-helix domains; Region: HTH; cl00088 279010008071 3H domain; Region: 3H; pfam02829 279010008072 prephenate dehydratase; Provisional; Region: PRK11898 279010008073 Prephenate dehydratase; Region: PDT; pfam00800 279010008074 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 279010008075 putative L-Phe binding site [chemical binding]; other site 279010008076 hypothetical protein; Provisional; Region: PRK04435 279010008077 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 279010008078 GTPase CgtA; Reviewed; Region: obgE; PRK12297 279010008079 GTP1/OBG; Region: GTP1_OBG; pfam01018 279010008080 Obg GTPase; Region: Obg; cd01898 279010008081 G1 box; other site 279010008082 GTP/Mg2+ binding site [chemical binding]; other site 279010008083 Switch I region; other site 279010008084 G2 box; other site 279010008085 G3 box; other site 279010008086 Switch II region; other site 279010008087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010008088 G4 box; other site 279010008089 G4 box; other site 279010008090 G5 box; other site 279010008091 G5 box; other site 279010008092 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 279010008093 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 279010008094 Protein of unknown function (DUF464); Region: DUF464; cl01080 279010008095 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 279010008096 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 279010008097 active site 279010008098 putative substrate binding region [chemical binding]; other site 279010008099 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010008100 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279010008101 putative hydrophobic ligand binding site [chemical binding]; other site 279010008102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010008103 dimerization interface [polypeptide binding]; other site 279010008104 putative DNA binding site [nucleotide binding]; other site 279010008105 putative Zn2+ binding site [ion binding]; other site 279010008106 septum site-determining protein MinD; Region: minD_bact; TIGR01968 279010008107 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 279010008108 Switch I; other site 279010008109 Switch II; other site 279010008110 septum formation inhibitor; Reviewed; Region: minC; PRK00513 279010008111 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 279010008112 rod shape-determining protein MreD; Region: MreD; cl01087 279010008113 rod shape-determining protein MreC; Provisional; Region: PRK13922 279010008114 bZIP transcription factor; Region: bZIP_1; cl02576 279010008115 rod shape-determining protein MreC; Region: MreC; pfam04085 279010008116 rod shape-determining protein MreB; Provisional; Region: PRK13927 279010008117 Cell division protein FtsA; Region: FtsA; cl11496 279010008118 hypothetical protein; Reviewed; Region: PRK00024 279010008119 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 279010008120 MPN+ (JAMM) motif; other site 279010008121 Zinc-binding site [ion binding]; other site 279010008122 Maf-like protein; Region: Maf; pfam02545 279010008123 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 279010008124 active site 279010008125 dimer interface [polypeptide binding]; other site 279010008126 Sporulation related domain; Region: SPOR; cl10051 279010008127 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 279010008128 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 279010008129 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 279010008130 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010008131 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010008132 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 279010008133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 279010008134 active site 279010008135 HIGH motif; other site 279010008136 nucleotide binding site [chemical binding]; other site 279010008137 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010008138 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 279010008139 active site 279010008140 KMSKS motif; other site 279010008141 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 279010008142 tRNA binding surface [nucleotide binding]; other site 279010008143 anticodon binding site; other site 279010008144 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 279010008145 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008146 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 279010008147 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 279010008148 putative peptidoglycan binding site; other site 279010008149 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 279010008150 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279010008151 inhibitor-cofactor binding pocket; inhibition site 279010008152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008153 catalytic residue [active] 279010008154 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 279010008155 dimer interface [polypeptide binding]; other site 279010008156 active site 279010008157 Schiff base residues; other site 279010008158 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 279010008159 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 279010008160 active site 279010008161 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 279010008162 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 279010008163 domain interfaces; other site 279010008164 active site 279010008165 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 279010008166 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 279010008167 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 279010008168 tRNA; other site 279010008169 putative tRNA binding site [nucleotide binding]; other site 279010008170 putative NADP binding site [chemical binding]; other site 279010008171 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 279010008172 Predicted GTPase [General function prediction only]; Region: COG0218 279010008173 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 279010008174 G1 box; other site 279010008175 GTP/Mg2+ binding site [chemical binding]; other site 279010008176 Switch I region; other site 279010008177 G2 box; other site 279010008178 G3 box; other site 279010008179 Switch II region; other site 279010008180 G4 box; other site 279010008181 G5 box; other site 279010008182 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 279010008183 Found in ATP-dependent protease La (LON); Region: LON; smart00464 279010008184 Found in ATP-dependent protease La (LON); Region: LON; smart00464 279010008185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008186 Walker A motif; other site 279010008187 ATP binding site [chemical binding]; other site 279010008188 Walker B motif; other site 279010008189 arginine finger; other site 279010008190 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 279010008191 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 279010008192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008193 Walker A motif; other site 279010008194 ATP binding site [chemical binding]; other site 279010008195 Walker B motif; other site 279010008196 arginine finger; other site 279010008197 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 279010008198 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 279010008199 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 279010008200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008201 Walker A motif; other site 279010008202 ATP binding site [chemical binding]; other site 279010008203 Walker B motif; other site 279010008204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 279010008205 trigger factor; Provisional; Region: tig; PRK01490 279010008206 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 279010008207 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 279010008208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010008209 binding surface 279010008210 Tetratricopeptide repeat; Region: TPR_16; pfam13432 279010008211 TPR motif; other site 279010008212 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 279010008213 substrate binding site [chemical binding]; other site 279010008214 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 279010008215 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 279010008216 substrate binding site [chemical binding]; other site 279010008217 ligand binding site [chemical binding]; other site 279010008218 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 279010008219 tartrate dehydrogenase; Provisional; Region: PRK08194 279010008220 2-isopropylmalate synthase; Validated; Region: PRK00915 279010008221 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 279010008222 active site 279010008223 catalytic residues [active] 279010008224 metal binding site [ion binding]; metal-binding site 279010008225 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 279010008226 ketol-acid reductoisomerase; Provisional; Region: PRK05479 279010008227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008228 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 279010008229 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 279010008230 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 279010008231 putative valine binding site [chemical binding]; other site 279010008232 dimer interface [polypeptide binding]; other site 279010008233 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 279010008234 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 279010008235 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010008236 PYR/PP interface [polypeptide binding]; other site 279010008237 dimer interface [polypeptide binding]; other site 279010008238 TPP binding site [chemical binding]; other site 279010008239 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 279010008240 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 279010008241 TPP-binding site [chemical binding]; other site 279010008242 dimer interface [polypeptide binding]; other site 279010008243 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 279010008244 homodimer interface [polypeptide binding]; other site 279010008245 substrate-cofactor binding pocket; other site 279010008246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008247 catalytic residue [active] 279010008248 glutamate dehydrogenase; Provisional; Region: PRK09414 279010008249 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279010008250 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 279010008251 NAD(P) binding site [chemical binding]; other site 279010008252 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279010008253 Phage terminase large subunit; Region: Terminase_3; cl12054 279010008254 Terminase-like family; Region: Terminase_6; pfam03237 279010008255 Uncharacterized conserved protein [Function unknown]; Region: COG5484 279010008256 Phage terminase small subunit; Region: Phage_terminase; pfam10668 279010008257 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 279010008258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 279010008259 cofactor binding site; other site 279010008260 DNA binding site [nucleotide binding] 279010008261 substrate interaction site [chemical binding]; other site 279010008262 Protein of unknown function, DUF600; Region: DUF600; cl04640 279010008263 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010008264 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 279010008265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279010008266 binding surface 279010008267 TPR motif; other site 279010008268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010008269 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 279010008270 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 279010008271 active site 279010008272 metal binding site [ion binding]; metal-binding site 279010008273 homotetramer interface [polypeptide binding]; other site 279010008274 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 279010008275 active site 279010008276 dimerization interface [polypeptide binding]; other site 279010008277 ribonuclease PH; Reviewed; Region: rph; PRK00173 279010008278 Ribonuclease PH; Region: RNase_PH_bact; cd11362 279010008279 hexamer interface [polypeptide binding]; other site 279010008280 active site 279010008281 Sporulation and spore germination; Region: Germane; cl11253 279010008282 Spore germination protein [General function prediction only]; Region: COG5401 279010008283 Sporulation and spore germination; Region: Germane; cl11253 279010008284 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 279010008285 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010008286 Helix-turn-helix domains; Region: HTH; cl00088 279010008287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010008288 DNA binding residues [nucleotide binding] 279010008289 dimerization interface [polypeptide binding]; other site 279010008290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008291 short chain dehydrogenase; Provisional; Region: PRK05693 279010008292 NAD(P) binding site [chemical binding]; other site 279010008293 active site 279010008294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279010008295 active site 279010008296 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 279010008297 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 279010008298 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 279010008299 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 279010008300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008301 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 279010008302 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 279010008303 putative Iron-sulfur protein interface [polypeptide binding]; other site 279010008304 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 279010008305 proximal heme binding site [chemical binding]; other site 279010008306 distal heme binding site [chemical binding]; other site 279010008307 putative dimer interface [polypeptide binding]; other site 279010008308 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 279010008309 aspartate kinase; Reviewed; Region: PRK06635 279010008310 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 279010008311 putative nucleotide binding site [chemical binding]; other site 279010008312 putative catalytic residues [active] 279010008313 putative Mg ion binding site [ion binding]; other site 279010008314 putative aspartate binding site [chemical binding]; other site 279010008315 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 279010008316 putative allosteric regulatory site; other site 279010008317 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 279010008318 putative allosteric regulatory residue; other site 279010008319 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 279010008320 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 279010008321 GIY-YIG motif/motif A; other site 279010008322 active site 279010008323 catalytic site [active] 279010008324 putative DNA binding site [nucleotide binding]; other site 279010008325 metal binding site [ion binding]; metal-binding site 279010008326 UvrB/uvrC motif; Region: UVR; pfam02151 279010008327 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 279010008328 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010008329 catalytic residues [active] 279010008330 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 279010008331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 279010008332 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 279010008333 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 279010008334 Ligand binding site [chemical binding]; other site 279010008335 Electron transfer flavoprotein domain; Region: ETF; pfam01012 279010008336 enoyl-CoA hydratase; Provisional; Region: PRK07658 279010008337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010008338 substrate binding site [chemical binding]; other site 279010008339 oxyanion hole (OAH) forming residues; other site 279010008340 trimer interface [polypeptide binding]; other site 279010008341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010008342 Helix-turn-helix domains; Region: HTH; cl00088 279010008343 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 279010008344 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 279010008345 AMP-binding enzyme; Region: AMP-binding; cl15778 279010008346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008347 Predicted membrane protein [Function unknown]; Region: COG3766 279010008348 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 279010008349 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 279010008350 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 279010008351 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 279010008352 Walker A/P-loop; other site 279010008353 ATP binding site [chemical binding]; other site 279010008354 Q-loop/lid; other site 279010008355 ABC transporter signature motif; other site 279010008356 Walker B; other site 279010008357 D-loop; other site 279010008358 H-loop/switch region; other site 279010008359 Smr domain; Region: Smr; cl02619 279010008360 hypothetical protein; Provisional; Region: PRK08609 279010008361 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 279010008362 active site 279010008363 primer binding site [nucleotide binding]; other site 279010008364 NTP binding site [chemical binding]; other site 279010008365 metal binding triad [ion binding]; metal-binding site 279010008366 Colicin V production protein; Region: Colicin_V; cl00567 279010008367 Cell division protein ZapA; Region: ZapA; cl01146 279010008368 ribonuclease HIII; Provisional; Region: PRK00996 279010008369 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 279010008370 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 279010008371 RNA/DNA hybrid binding site [nucleotide binding]; other site 279010008372 active site 279010008373 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279010008374 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010008375 Walker A/P-loop; other site 279010008376 ATP binding site [chemical binding]; other site 279010008377 Q-loop/lid; other site 279010008378 ABC transporter signature motif; other site 279010008379 Walker B; other site 279010008380 D-loop; other site 279010008381 H-loop/switch region; other site 279010008382 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 279010008383 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279010008384 putative tRNA-binding site [nucleotide binding]; other site 279010008385 B3/4 domain; Region: B3_4; cl11458 279010008386 tRNA synthetase B5 domain; Region: B5; cl08394 279010008387 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 279010008388 dimer interface [polypeptide binding]; other site 279010008389 motif 1; other site 279010008390 motif 3; other site 279010008391 motif 2; other site 279010008392 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 279010008393 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 279010008394 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 279010008395 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 279010008396 dimer interface [polypeptide binding]; other site 279010008397 motif 1; other site 279010008398 active site 279010008399 motif 2; other site 279010008400 motif 3; other site 279010008401 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 279010008402 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 279010008403 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 279010008404 Small, acid-soluble spore protein I; Region: SSPI; cl07940 279010008405 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 279010008406 Carbon starvation protein CstA; Region: CstA; pfam02554 279010008407 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 279010008408 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 279010008409 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 279010008410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008411 dimer interface [polypeptide binding]; other site 279010008412 conserved gate region; other site 279010008413 putative PBP binding loops; other site 279010008414 ABC-ATPase subunit interface; other site 279010008415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008416 dimer interface [polypeptide binding]; other site 279010008417 conserved gate region; other site 279010008418 putative PBP binding loops; other site 279010008419 ABC-ATPase subunit interface; other site 279010008420 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010008421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010008422 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 279010008423 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010008424 active site 279010008425 metal binding site [ion binding]; metal-binding site 279010008426 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 279010008427 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 279010008428 intersubunit interface [polypeptide binding]; other site 279010008429 active site 279010008430 Zn2+ binding site [ion binding]; other site 279010008431 ribulokinase; Provisional; Region: PRK04123 279010008432 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 279010008433 putative active site [active] 279010008434 putative MgATP binding site [chemical binding]; other site 279010008435 putative N- and C-terminal domain interface [polypeptide binding]; other site 279010008436 carbohydrate binding site [chemical binding]; other site 279010008437 metal binding site [ion binding]; metal-binding site 279010008438 homodimer interface [polypeptide binding]; other site 279010008439 L-arabinose isomerase; Provisional; Region: PRK02929 279010008440 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 279010008441 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010008442 trimer interface [polypeptide binding]; other site 279010008443 putative substrate binding site [chemical binding]; other site 279010008444 putative metal binding site [ion binding]; other site 279010008445 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010008446 substrate binding site [chemical binding]; other site 279010008447 active site 279010008448 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010008449 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279010008450 oligomer interface [polypeptide binding]; other site 279010008451 active site 279010008452 metal binding site [ion binding]; metal-binding site 279010008453 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 279010008454 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 279010008455 23S rRNA binding site [nucleotide binding]; other site 279010008456 L21 binding site [polypeptide binding]; other site 279010008457 L13 binding site [polypeptide binding]; other site 279010008458 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 279010008459 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 279010008460 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 279010008461 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 279010008462 LrgB-like family; Region: LrgB; cl00596 279010008463 LrgA family; Region: LrgA; cl00608 279010008464 PhoD-like phosphatase; Region: PhoD; pfam09423 279010008465 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 279010008466 putative active site [active] 279010008467 putative metal binding site [ion binding]; other site 279010008468 two-component response regulator; Provisional; Region: PRK14084 279010008469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008470 active site 279010008471 phosphorylation site [posttranslational modification] 279010008472 intermolecular recognition site; other site 279010008473 dimerization interface [polypeptide binding]; other site 279010008474 LytTr DNA-binding domain; Region: LytTR; cl04498 279010008475 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 279010008476 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 279010008477 GAF domain; Region: GAF; cl15785 279010008478 Histidine kinase; Region: His_kinase; pfam06580 279010008479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010008480 ATP binding site [chemical binding]; other site 279010008481 Mg2+ binding site [ion binding]; other site 279010008482 G-X-G motif; other site 279010008483 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 279010008484 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 279010008485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010008486 motif II; other site 279010008487 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 279010008488 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279010008489 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 279010008490 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279010008491 active site 279010008492 dimer interface [polypeptide binding]; other site 279010008493 motif 1; other site 279010008494 motif 2; other site 279010008495 motif 3; other site 279010008496 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279010008497 anticodon binding site; other site 279010008498 YtxC-like family; Region: YtxC; cl08500 279010008499 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010008500 primosomal protein DnaI; Reviewed; Region: PRK08939 279010008501 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 279010008502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010008503 Walker A motif; other site 279010008504 ATP binding site [chemical binding]; other site 279010008505 Walker B motif; other site 279010008506 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 279010008507 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 279010008508 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 279010008509 ATP cone domain; Region: ATP-cone; pfam03477 279010008510 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 279010008511 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 279010008512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008513 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 279010008514 Pectate lyase; Region: Pec_lyase_C; cl01593 279010008515 dephospho-CoA kinase; Region: TIGR00152 279010008516 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 279010008517 CoA-binding site [chemical binding]; other site 279010008518 ATP-binding [chemical binding]; other site 279010008519 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 279010008520 Domain of unknown function DUF; Region: DUF204; pfam02659 279010008521 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 279010008522 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 279010008523 DNA binding site [nucleotide binding] 279010008524 catalytic residue [active] 279010008525 H2TH interface [polypeptide binding]; other site 279010008526 putative catalytic residues [active] 279010008527 turnover-facilitating residue; other site 279010008528 intercalation triad [nucleotide binding]; other site 279010008529 8OG recognition residue [nucleotide binding]; other site 279010008530 putative reading head residues; other site 279010008531 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 279010008532 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279010008533 DNA polymerase I; Provisional; Region: PRK05755 279010008534 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279010008535 active site 279010008536 metal binding site 1 [ion binding]; metal-binding site 279010008537 putative 5' ssDNA interaction site; other site 279010008538 metal binding site 3; metal-binding site 279010008539 metal binding site 2 [ion binding]; metal-binding site 279010008540 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279010008541 putative DNA binding site [nucleotide binding]; other site 279010008542 putative metal binding site [ion binding]; other site 279010008543 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 279010008544 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 279010008545 active site 279010008546 DNA binding site [nucleotide binding] 279010008547 catalytic site [active] 279010008548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 279010008549 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279010008550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010008551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010008552 dimer interface [polypeptide binding]; other site 279010008553 phosphorylation site [posttranslational modification] 279010008554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010008555 ATP binding site [chemical binding]; other site 279010008556 Mg2+ binding site [ion binding]; other site 279010008557 G-X-G motif; other site 279010008558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010008559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010008560 active site 279010008561 phosphorylation site [posttranslational modification] 279010008562 intermolecular recognition site; other site 279010008563 dimerization interface [polypeptide binding]; other site 279010008564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010008565 DNA binding site [nucleotide binding] 279010008566 malate dehydrogenase; Reviewed; Region: PRK06223 279010008567 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 279010008568 NAD(P) binding site [chemical binding]; other site 279010008569 dimer interface [polypeptide binding]; other site 279010008570 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010008571 substrate binding site [chemical binding]; other site 279010008572 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 279010008573 isocitrate dehydrogenase; Validated; Region: PRK07362 279010008574 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 279010008575 dimer interface [polypeptide binding]; other site 279010008576 Citrate synthase; Region: Citrate_synt; pfam00285 279010008577 active site 279010008578 citrylCoA binding site [chemical binding]; other site 279010008579 oxalacetate/citrate binding site [chemical binding]; other site 279010008580 coenzyme A binding site [chemical binding]; other site 279010008581 catalytic triad [active] 279010008582 Protein of unknown function (DUF441); Region: DUF441; cl01041 279010008583 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 279010008584 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 279010008585 pyruvate kinase; Provisional; Region: PRK06354 279010008586 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 279010008587 domain interfaces; other site 279010008588 active site 279010008589 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 279010008590 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 279010008591 active site 279010008592 ADP/pyrophosphate binding site [chemical binding]; other site 279010008593 dimerization interface [polypeptide binding]; other site 279010008594 allosteric effector site; other site 279010008595 fructose-1,6-bisphosphate binding site; other site 279010008596 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010008597 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 279010008598 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 279010008599 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 279010008600 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 279010008601 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 279010008602 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010008603 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 279010008604 putative NAD(P) binding site [chemical binding]; other site 279010008605 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 279010008606 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 279010008607 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 279010008608 generic binding surface I; other site 279010008609 generic binding surface II; other site 279010008610 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 279010008611 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 279010008612 DHH family; Region: DHH; pfam01368 279010008613 DHHA1 domain; Region: DHHA1; pfam02272 279010008614 YtpI-like protein; Region: YtpI; pfam14007 279010008615 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 279010008616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010008617 DNA-binding site [nucleotide binding]; DNA binding site 279010008618 DRTGG domain; Region: DRTGG; cl12147 279010008619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 279010008620 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 279010008621 active site 2 [active] 279010008622 active site 1 [active] 279010008623 Helix-turn-helix domains; Region: HTH; cl00088 279010008624 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 279010008625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010008626 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010008627 classical (c) SDRs; Region: SDR_c; cd05233 279010008628 NAD(P) binding site [chemical binding]; other site 279010008629 active site 279010008630 argininosuccinate lyase; Provisional; Region: PRK00855 279010008631 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 279010008632 active sites [active] 279010008633 tetramer interface [polypeptide binding]; other site 279010008634 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 279010008635 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 279010008636 ANP binding site [chemical binding]; other site 279010008637 Substrate Binding Site II [chemical binding]; other site 279010008638 Substrate Binding Site I [chemical binding]; other site 279010008639 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 279010008640 MPT binding site; other site 279010008641 trimer interface [polypeptide binding]; other site 279010008642 Acetokinase family; Region: Acetate_kinase; cl01029 279010008643 propionate/acetate kinase; Provisional; Region: PRK12379 279010008644 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 279010008645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008646 S-adenosylmethionine binding site [chemical binding]; other site 279010008647 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 279010008648 dimer interface [polypeptide binding]; other site 279010008649 catalytic triad [active] 279010008650 peroxidatic and resolving cysteines [active] 279010008651 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 279010008652 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 279010008653 RDD family; Region: RDD; cl00746 279010008654 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 279010008655 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 279010008656 tandem repeat interface [polypeptide binding]; other site 279010008657 oligomer interface [polypeptide binding]; other site 279010008658 active site residues [active] 279010008659 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 279010008660 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 279010008661 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 279010008662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010008663 putative substrate translocation pore; other site 279010008664 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010008665 Helix-turn-helix domains; Region: HTH; cl00088 279010008666 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 279010008667 AMP-binding enzyme; Region: AMP-binding; cl15778 279010008668 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008669 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 279010008670 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 279010008671 THUMP domain; Region: THUMP; cl12076 279010008672 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 279010008673 Ligand Binding Site [chemical binding]; other site 279010008674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010008675 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 279010008676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010008677 catalytic residue [active] 279010008678 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 279010008679 Helix-turn-helix domains; Region: HTH; cl00088 279010008680 Helix-turn-helix domains; Region: HTH; cl00088 279010008681 putative transposase OrfB; Reviewed; Region: PHA02517 279010008682 Integrase core domain; Region: rve; cl01316 279010008683 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 279010008684 histidinol-phosphatase; Reviewed; Region: PRK08123 279010008685 PHP-associated; Region: PHP_C; pfam13263 279010008686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010008687 Helix-turn-helix domains; Region: HTH; cl00088 279010008688 GAF domain; Region: GAF; cl15785 279010008689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010008690 metal binding site [ion binding]; metal-binding site 279010008691 active site 279010008692 I-site; other site 279010008693 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 279010008694 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 279010008695 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010008696 RNA binding surface [nucleotide binding]; other site 279010008697 Protein of unknown function (DUF805); Region: DUF805; cl01224 279010008698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010008699 Helix-turn-helix domains; Region: HTH; cl00088 279010008700 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 279010008701 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 279010008702 active site 279010008703 HIGH motif; other site 279010008704 dimer interface [polypeptide binding]; other site 279010008705 KMSKS motif; other site 279010008706 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010008707 RNA binding surface [nucleotide binding]; other site 279010008708 acetyl-CoA synthetase; Provisional; Region: PRK04319 279010008709 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 279010008710 AMP-binding enzyme; Region: AMP-binding; cl15778 279010008711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010008712 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010008713 FOG: CBS domain [General function prediction only]; Region: COG0517 279010008714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 279010008715 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 279010008716 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 279010008717 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 279010008718 flagellar motor protein MotS; Reviewed; Region: PRK06925 279010008719 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 279010008720 ligand binding site [chemical binding]; other site 279010008721 flagellar motor protein MotP; Reviewed; Region: PRK06926 279010008722 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 279010008723 catabolite control protein A; Region: ccpA; TIGR01481 279010008724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010008725 DNA binding site [nucleotide binding] 279010008726 domain linker motif; other site 279010008727 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 279010008728 dimerization interface [polypeptide binding]; other site 279010008729 effector binding site; other site 279010008730 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 279010008731 Chorismate mutase type II; Region: CM_2; cl00693 279010008732 NeuB family; Region: NeuB; cl00496 279010008733 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279010008734 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 279010008735 YtxH-like protein; Region: YtxH; cl02079 279010008736 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 279010008737 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 279010008738 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279010008739 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010008740 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279010008741 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 279010008742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010008743 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 279010008744 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279010008745 putative tRNA-binding site [nucleotide binding]; other site 279010008746 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 279010008747 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010008748 catalytic residues [active] 279010008749 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 279010008750 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279010008751 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279010008752 oligomer interface [polypeptide binding]; other site 279010008753 active site 279010008754 metal binding site [ion binding]; metal-binding site 279010008755 Predicted small secreted protein [Function unknown]; Region: COG5584 279010008756 malate dehydrogenase; Provisional; Region: PRK13529 279010008757 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010008758 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 279010008759 NAD(P) binding site [chemical binding]; other site 279010008760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010008761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010008762 S-adenosylmethionine binding site [chemical binding]; other site 279010008763 YtzH-like protein; Region: YtzH; pfam14165 279010008764 Phosphotransferase enzyme family; Region: APH; pfam01636 279010008765 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 279010008766 active site 279010008767 substrate binding site [chemical binding]; other site 279010008768 ATP binding site [chemical binding]; other site 279010008769 pullulanase, type I; Region: pulA_typeI; TIGR02104 279010008770 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 279010008771 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 279010008772 Ca binding site [ion binding]; other site 279010008773 active site 279010008774 catalytic site [active] 279010008775 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 279010008776 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 279010008777 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 279010008778 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010008779 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279010008780 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279010008781 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279010008782 dimer interface [polypeptide binding]; other site 279010008783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010008784 catalytic residue [active] 279010008785 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 279010008786 dipeptidase PepV; Reviewed; Region: PRK07318 279010008787 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 279010008788 active site 279010008789 metal binding site [ion binding]; metal-binding site 279010008790 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 279010008791 Helix-turn-helix domains; Region: HTH; cl00088 279010008792 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279010008793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279010008794 RNA binding surface [nucleotide binding]; other site 279010008795 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 279010008796 active site 279010008797 uracil binding [chemical binding]; other site 279010008798 stage V sporulation protein B; Region: spore_V_B; TIGR02900 279010008799 MatE; Region: MatE; cl10513 279010008800 HI0933-like protein; Region: HI0933_like; pfam03486 279010008801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008803 BCCT family transporter; Region: BCCT; cl00569 279010008804 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 279010008805 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279010008806 active site residue [active] 279010008807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010008808 TPR motif; other site 279010008809 binding surface 279010008810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010008811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010008812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010008813 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 279010008814 Protein of unknown function, DUF624; Region: DUF624; cl02369 279010008815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010008817 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 279010008818 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 279010008819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008820 ABC-ATPase subunit interface; other site 279010008821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010008822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010008823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010008824 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010008825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010008826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010008827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008828 dimer interface [polypeptide binding]; other site 279010008829 conserved gate region; other site 279010008830 putative PBP binding loops; other site 279010008831 ABC-ATPase subunit interface; other site 279010008832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008833 NAD(P) binding site [chemical binding]; other site 279010008834 active site 279010008835 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 279010008836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008838 putative transporter; Provisional; Region: PRK11021 279010008839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279010008840 Helix-turn-helix domains; Region: HTH; cl00088 279010008841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010008842 dimerization interface [polypeptide binding]; other site 279010008843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010008844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 279010008845 active site 279010008846 metal binding site [ion binding]; metal-binding site 279010008847 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 279010008848 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279010008849 HIGH motif; other site 279010008850 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279010008851 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279010008852 active site 279010008853 KMSKS motif; other site 279010008854 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 279010008855 tRNA binding surface [nucleotide binding]; other site 279010008856 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 279010008857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010008858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010008859 putative substrate translocation pore; other site 279010008860 NMT1-like family; Region: NMT1_2; cl15260 279010008861 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 279010008862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279010008863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279010008864 FtsX-like permease family; Region: FtsX; cl15850 279010008865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010008866 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010008867 Walker A/P-loop; other site 279010008868 ATP binding site [chemical binding]; other site 279010008869 Q-loop/lid; other site 279010008870 ABC transporter signature motif; other site 279010008871 Walker B; other site 279010008872 D-loop; other site 279010008873 H-loop/switch region; other site 279010008874 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010008875 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010008876 Walker A/P-loop; other site 279010008877 ATP binding site [chemical binding]; other site 279010008878 Q-loop/lid; other site 279010008879 ABC transporter signature motif; other site 279010008880 Walker B; other site 279010008881 D-loop; other site 279010008882 H-loop/switch region; other site 279010008883 Predicted transcriptional regulators [Transcription]; Region: COG1725 279010008884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010008885 DNA-binding site [nucleotide binding]; DNA binding site 279010008886 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 279010008887 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 279010008888 hypothetical protein; Provisional; Region: PRK08317 279010008889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010008890 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010008891 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010008892 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 279010008893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008894 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 279010008895 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008896 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 279010008897 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 279010008898 trimer interface [polypeptide binding]; other site 279010008899 putative metal binding site [ion binding]; other site 279010008900 PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380 279010008901 active site 279010008902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010008903 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 279010008904 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 279010008905 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 279010008906 active site 279010008907 dimer interface [polypeptide binding]; other site 279010008908 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010008909 Ligand Binding Site [chemical binding]; other site 279010008910 Molecular Tunnel; other site 279010008911 S-adenosylmethionine synthetase; Validated; Region: PRK05250 279010008912 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 279010008913 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 279010008914 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 279010008915 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 279010008916 active site 279010008917 substrate-binding site [chemical binding]; other site 279010008918 metal-binding site [ion binding] 279010008919 ATP binding site [chemical binding]; other site 279010008920 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279010008921 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279010008922 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 279010008923 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008924 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 279010008925 NMT1-like family; Region: NMT1_2; cl15260 279010008926 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 279010008927 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 279010008928 Walker A/P-loop; other site 279010008929 ATP binding site [chemical binding]; other site 279010008930 Q-loop/lid; other site 279010008931 ABC transporter signature motif; other site 279010008932 Walker B; other site 279010008933 D-loop; other site 279010008934 H-loop/switch region; other site 279010008935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 279010008936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010008937 dimer interface [polypeptide binding]; other site 279010008938 conserved gate region; other site 279010008939 putative PBP binding loops; other site 279010008940 ABC-ATPase subunit interface; other site 279010008941 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 279010008942 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 279010008943 nudix motif; other site 279010008944 Holin family; Region: Phage_holin_4; cl01989 279010008945 Ferritin-like domain; Region: Ferritin; pfam00210 279010008946 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 279010008947 dimerization interface [polypeptide binding]; other site 279010008948 DPS ferroxidase diiron center [ion binding]; other site 279010008949 ion pore; other site 279010008950 FixH; Region: FixH; cl01254 279010008951 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 279010008952 Haemolytic domain; Region: Haemolytic; cl00506 279010008953 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 279010008954 active site clefts [active] 279010008955 zinc binding site [ion binding]; other site 279010008956 dimer interface [polypeptide binding]; other site 279010008957 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279010008958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010008959 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 279010008960 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010008961 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 279010008962 intersubunit interface [polypeptide binding]; other site 279010008963 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 279010008964 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 279010008965 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 279010008966 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 279010008967 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 279010008968 active site 279010008969 octamer interface [polypeptide binding]; other site 279010008970 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 279010008971 AMP-binding enzyme; Region: AMP-binding; cl15778 279010008972 AMP-binding enzyme; Region: AMP-binding; cl15778 279010008973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010008974 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 279010008975 substrate binding site [chemical binding]; other site 279010008976 oxyanion hole (OAH) forming residues; other site 279010008977 trimer interface [polypeptide binding]; other site 279010008978 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010008979 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 279010008980 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 279010008981 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 279010008982 dimer interface [polypeptide binding]; other site 279010008983 tetramer interface [polypeptide binding]; other site 279010008984 PYR/PP interface [polypeptide binding]; other site 279010008985 TPP binding site [chemical binding]; other site 279010008986 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 279010008987 TPP-binding site; other site 279010008988 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 279010008989 chorismate binding enzyme; Region: Chorismate_bind; cl10555 279010008990 UbiA prenyltransferase family; Region: UbiA; cl00337 279010008991 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 279010008992 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 279010008993 homodimer interface [polypeptide binding]; other site 279010008994 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 279010008995 active site pocket [active] 279010008996 glycogen synthase; Provisional; Region: glgA; PRK00654 279010008997 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 279010008998 ADP-binding pocket [chemical binding]; other site 279010008999 homodimer interface [polypeptide binding]; other site 279010009000 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 279010009001 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 279010009002 ligand binding site; other site 279010009003 oligomer interface; other site 279010009004 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 279010009005 dimer interface [polypeptide binding]; other site 279010009006 N-terminal domain interface [polypeptide binding]; other site 279010009007 sulfate 1 binding site; other site 279010009008 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 279010009009 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 279010009010 ligand binding site; other site 279010009011 oligomer interface; other site 279010009012 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 279010009013 dimer interface [polypeptide binding]; other site 279010009014 N-terminal domain interface [polypeptide binding]; other site 279010009015 sulfate 1 binding site; other site 279010009016 glycogen branching enzyme; Provisional; Region: PRK12313 279010009017 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 279010009018 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 279010009019 active site 279010009020 catalytic site [active] 279010009021 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 279010009022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010009023 DNA-binding site [nucleotide binding]; DNA binding site 279010009024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010009025 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 279010009026 putative dimerization interface [polypeptide binding]; other site 279010009027 putative ligand binding site [chemical binding]; other site 279010009028 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 279010009029 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 279010009030 active site 279010009031 catalytic site [active] 279010009032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009033 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 279010009034 putative substrate binding pocket [chemical binding]; other site 279010009035 AC domain interface; other site 279010009036 catalytic triad [active] 279010009037 AB domain interface; other site 279010009038 interchain disulfide; other site 279010009039 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279010009040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009041 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 279010009042 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010009043 Cation transport protein; Region: TrkH; cl10514 279010009044 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279010009045 EamA-like transporter family; Region: EamA; cl01037 279010009046 DinB superfamily; Region: DinB_2; pfam12867 279010009047 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 279010009048 MOSC domain; Region: MOSC; pfam03473 279010009049 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 279010009050 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 279010009051 active site 279010009052 NAD binding site [chemical binding]; other site 279010009053 metal binding site [ion binding]; metal-binding site 279010009054 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 279010009055 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010009056 tetramerization interface [polypeptide binding]; other site 279010009057 NAD(P) binding site [chemical binding]; other site 279010009058 catalytic residues [active] 279010009059 Predicted transcriptional regulators [Transcription]; Region: COG1510 279010009060 Helix-turn-helix domains; Region: HTH; cl00088 279010009061 Sodium:solute symporter family; Region: SSF; cl00456 279010009062 Leucine carboxyl methyltransferase; Region: LCM; cl01306 279010009063 alanine racemase; Region: alr; TIGR00492 279010009064 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 279010009065 active site 279010009066 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279010009067 dimer interface [polypeptide binding]; other site 279010009068 substrate binding site [chemical binding]; other site 279010009069 catalytic residues [active] 279010009070 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 279010009071 Cupin domain; Region: Cupin_2; cl09118 279010009072 Cupin domain; Region: Cupin_2; cl09118 279010009073 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 279010009074 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 279010009075 Proteins of 100 residues with WXG; Region: WXG100; cl02005 279010009076 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 279010009077 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 279010009078 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 279010009079 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010009080 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 279010009081 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010009082 putative active site [active] 279010009083 putative metal binding site [ion binding]; other site 279010009084 Bacitracin resistance protein BacA; Region: BacA; cl00858 279010009085 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010009086 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 279010009087 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010009088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009089 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010009090 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 279010009091 proposed catalytic triad [active] 279010009092 conserved cys residue [active] 279010009093 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009094 Cache domain; Region: Cache_1; pfam02743 279010009095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009096 dimerization interface [polypeptide binding]; other site 279010009097 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009099 dimer interface [polypeptide binding]; other site 279010009100 putative CheW interface [polypeptide binding]; other site 279010009101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009102 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009103 Cache domain; Region: Cache_1; pfam02743 279010009104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009105 dimerization interface [polypeptide binding]; other site 279010009106 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009108 dimer interface [polypeptide binding]; other site 279010009109 putative CheW interface [polypeptide binding]; other site 279010009110 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 279010009111 Cache domain; Region: Cache_1; pfam02743 279010009112 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 279010009113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009114 dimerization interface [polypeptide binding]; other site 279010009115 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010009116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010009117 dimer interface [polypeptide binding]; other site 279010009118 putative CheW interface [polypeptide binding]; other site 279010009119 transglutaminase; Provisional; Region: tgl; PRK03187 279010009120 Nitronate monooxygenase; Region: NMO; pfam03060 279010009121 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 279010009122 FMN binding site [chemical binding]; other site 279010009123 substrate binding site [chemical binding]; other site 279010009124 putative catalytic residue [active] 279010009125 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 279010009126 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279010009127 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279010009128 Ca binding site [ion binding]; other site 279010009129 active site 279010009130 catalytic site [active] 279010009131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009132 Helix-turn-helix domains; Region: HTH; cl00088 279010009133 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 279010009134 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010009135 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010009136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010009137 Transporter associated domain; Region: CorC_HlyC; cl08393 279010009138 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 279010009139 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 279010009140 Ion channel; Region: Ion_trans_2; cl11596 279010009141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009142 Calcium-activated BK potassium channel alpha subunit; Region: BK_channel_a; pfam03493 279010009143 YugN-like family; Region: YugN; pfam08868 279010009144 Protein of unknown function (DUF421); Region: DUF421; cl00990 279010009145 TspO/MBR family; Region: TspO_MBR; cl01379 279010009146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010009147 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010009148 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 279010009149 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 279010009150 active site 279010009151 dimer interface [polypeptide binding]; other site 279010009152 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 279010009153 dimer interface [polypeptide binding]; other site 279010009154 active site 279010009155 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 279010009156 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 279010009157 dimer interface [polypeptide binding]; other site 279010009158 active site 279010009159 metal binding site [ion binding]; metal-binding site 279010009160 Domain of unknown function (DUF378); Region: DUF378; cl00943 279010009161 general stress protein 13; Validated; Region: PRK08059 279010009162 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 279010009163 RNA binding site [nucleotide binding]; other site 279010009164 hypothetical protein; Validated; Region: PRK07682 279010009165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010009166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009167 homodimer interface [polypeptide binding]; other site 279010009168 catalytic residue [active] 279010009169 Helix-turn-helix domains; Region: HTH; cl00088 279010009170 Helix-turn-helix domains; Region: HTH; cl00088 279010009171 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010009172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279010009173 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 279010009174 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 279010009175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010009176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009177 homodimer interface [polypeptide binding]; other site 279010009178 catalytic residue [active] 279010009179 Kinase associated protein B; Region: KapB; pfam08810 279010009180 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 279010009181 active site 279010009182 substrate binding site [chemical binding]; other site 279010009183 catalytic site [active] 279010009184 drug efflux system protein MdtG; Provisional; Region: PRK09874 279010009185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009186 putative substrate translocation pore; other site 279010009187 Transglycosylase; Region: Transgly; cl07896 279010009188 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010009189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010009190 Protein of unknown function, DUF393; Region: DUF393; cl01136 279010009191 Meckelin (Transmembrane protein 67); Region: Meckelin; pfam09773 279010009192 sensory histidine kinase DcuS; Provisional; Region: PRK11086 279010009193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 279010009194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009195 ATP binding site [chemical binding]; other site 279010009196 Mg2+ binding site [ion binding]; other site 279010009197 G-X-G motif; other site 279010009198 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 279010009199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009200 active site 279010009201 phosphorylation site [posttranslational modification] 279010009202 intermolecular recognition site; other site 279010009203 dimerization interface [polypeptide binding]; other site 279010009204 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 279010009205 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 279010009206 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 279010009207 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 279010009208 Helix-turn-helix domains; Region: HTH; cl00088 279010009209 putative transposase OrfB; Reviewed; Region: PHA02517 279010009210 Integrase core domain; Region: rve; cl01316 279010009211 Helix-turn-helix domains; Region: HTH; cl00088 279010009212 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 279010009213 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 279010009214 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 279010009215 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 279010009216 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 279010009217 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 279010009218 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 279010009219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 279010009220 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 279010009221 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 279010009222 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 279010009223 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 279010009224 CoenzymeA binding site [chemical binding]; other site 279010009225 subunit interaction site [polypeptide binding]; other site 279010009226 PHB binding site; other site 279010009227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009229 active site 279010009230 phosphorylation site [posttranslational modification] 279010009231 intermolecular recognition site; other site 279010009232 dimerization interface [polypeptide binding]; other site 279010009233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010009234 DNA binding residues [nucleotide binding] 279010009235 dimerization interface [polypeptide binding]; other site 279010009236 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 279010009237 Histidine kinase; Region: HisKA_3; pfam07730 279010009238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009239 ATP binding site [chemical binding]; other site 279010009240 Mg2+ binding site [ion binding]; other site 279010009241 G-X-G motif; other site 279010009242 Helix-turn-helix domains; Region: HTH; cl00088 279010009243 putative transposase OrfB; Reviewed; Region: PHA02517 279010009244 Integrase core domain; Region: rve; cl01316 279010009245 Helix-turn-helix domains; Region: HTH; cl00088 279010009246 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010009247 protein binding site [polypeptide binding]; other site 279010009248 Bacillus competence pheromone ComX; Region: ComX; pfam05952 279010009249 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 279010009250 substrate binding pocket [chemical binding]; other site 279010009251 aspartate-rich region 2; other site 279010009252 substrate-Mg2+ binding site; other site 279010009253 DegQ (SacQ) family; Region: DegQ; pfam08181 279010009254 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 279010009255 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 279010009256 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 279010009257 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 279010009258 active site 279010009259 Isochorismatase family; Region: Isochorismatase; pfam00857 279010009260 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 279010009261 catalytic triad [active] 279010009262 conserved cis-peptide bond; other site 279010009263 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 279010009264 YueH-like protein; Region: YueH; pfam14166 279010009265 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 279010009266 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279010009267 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 279010009268 Rrf2 family protein; Region: rrf2_super; TIGR00738 279010009269 Helix-turn-helix domains; Region: HTH; cl00088 279010009270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010009271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010009272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010009273 short chain dehydrogenase; Provisional; Region: PRK06924 279010009274 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 279010009275 NADP binding site [chemical binding]; other site 279010009276 homodimer interface [polypeptide binding]; other site 279010009277 active site 279010009278 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 279010009279 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010009280 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 279010009281 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 279010009282 Predicted membrane protein [Function unknown]; Region: COG1511 279010009283 Haemolysin XhlA; Region: XhlA; pfam10779 279010009284 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 279010009285 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 279010009286 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 279010009287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010009288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010009289 Domain of unknown function DUF87; Region: DUF87; pfam01935 279010009290 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 279010009291 Ubiquitin-like proteins; Region: UBQ; cl00155 279010009292 Proteins of 100 residues with WXG; Region: WXG100; cl02005 279010009293 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010009294 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010009295 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010009296 Helix-turn-helix domains; Region: HTH; cl00088 279010009297 alanine dehydrogenase; Region: alaDH; TIGR00518 279010009298 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 279010009299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009300 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 279010009301 Moco binding site; other site 279010009302 metal coordination site [ion binding]; other site 279010009303 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 279010009304 Predicted permease [General function prediction only]; Region: COG2056 279010009305 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 279010009306 multifunctional aminopeptidase A; Provisional; Region: PRK00913 279010009307 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 279010009308 interface (dimer of trimers) [polypeptide binding]; other site 279010009309 Substrate-binding/catalytic site; other site 279010009310 Zn-binding sites [ion binding]; other site 279010009311 Divergent PAP2 family; Region: DUF212; cl00855 279010009312 3D domain; Region: 3D; cl01439 279010009313 Putative membrane protein; Region: YuiB; pfam14068 279010009314 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010009315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009316 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279010009317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009318 Cold-inducible protein YdjO; Region: YdjO; pfam14169 279010009319 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010009320 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 279010009321 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 279010009322 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 279010009323 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 279010009324 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 279010009325 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010009326 Nucleoside recognition; Region: Gate; cl00486 279010009327 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010009328 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 279010009329 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279010009330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010009331 Protein of unknown function (DUF419); Region: DUF419; cl15265 279010009332 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009333 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 279010009334 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 279010009335 NifU-like domain; Region: NifU; cl00484 279010009336 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 279010009337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 279010009338 structural tetrad; other site 279010009339 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010009340 homoserine kinase; Provisional; Region: PRK01212 279010009341 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010009342 threonine synthase; Reviewed; Region: PRK06721 279010009343 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 279010009344 homodimer interface [polypeptide binding]; other site 279010009345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010009346 catalytic residue [active] 279010009347 homoserine dehydrogenase; Provisional; Region: PRK06349 279010009348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009349 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 279010009350 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 279010009351 glyoxylate reductase; Reviewed; Region: PRK13243 279010009352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009353 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279010009354 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 279010009355 tetramer interfaces [polypeptide binding]; other site 279010009356 binuclear metal-binding site [ion binding]; other site 279010009357 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 279010009358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010009359 active site 279010009360 motif I; other site 279010009361 motif II; other site 279010009362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010009363 Protein of unknown function DUF86; Region: DUF86; cl01031 279010009364 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 279010009365 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 279010009366 lipoyl synthase; Provisional; Region: PRK05481 279010009367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010009368 FeS/SAM binding site; other site 279010009369 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010009370 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 279010009371 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 279010009372 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 279010009373 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279010009374 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 279010009375 active site 279010009376 metal binding site [ion binding]; metal-binding site 279010009377 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279010009378 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 279010009379 Protein of unknown function DUF72; Region: DUF72; cl00777 279010009380 Helix-turn-helix domains; Region: HTH; cl00088 279010009381 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 279010009382 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 279010009383 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010009384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009385 catalytic residue [active] 279010009386 allantoate amidohydrolase; Reviewed; Region: PRK12893 279010009387 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 279010009388 active site 279010009389 metal binding site [ion binding]; metal-binding site 279010009390 dimer interface [polypeptide binding]; other site 279010009391 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 279010009392 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 279010009393 Helix-turn-helix domains; Region: HTH; cl00088 279010009394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010009396 putative substrate translocation pore; other site 279010009397 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 279010009398 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010009399 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010009400 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010009401 Endonuclease I; Region: Endonuclease_1; cl01003 279010009402 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 279010009403 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 279010009404 FAD dependent oxidoreductase; Region: DAO; pfam01266 279010009405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009406 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 279010009407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 279010009408 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 279010009409 FeS assembly protein SufB; Region: sufB; TIGR01980 279010009410 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 279010009411 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 279010009412 trimerization site [polypeptide binding]; other site 279010009413 active site 279010009414 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279010009415 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 279010009416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009417 catalytic residue [active] 279010009418 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 279010009419 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 279010009420 FeS assembly ATPase SufC; Region: sufC; TIGR01978 279010009421 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 279010009422 Walker A/P-loop; other site 279010009423 ATP binding site [chemical binding]; other site 279010009424 Q-loop/lid; other site 279010009425 ABC transporter signature motif; other site 279010009426 Walker B; other site 279010009427 D-loop; other site 279010009428 H-loop/switch region; other site 279010009429 Cation efflux family; Region: Cation_efflux; cl00316 279010009430 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279010009431 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 279010009432 NMT1-like family; Region: NMT1_2; cl15260 279010009433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009434 dimer interface [polypeptide binding]; other site 279010009435 conserved gate region; other site 279010009436 putative PBP binding loops; other site 279010009437 ABC-ATPase subunit interface; other site 279010009438 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 279010009439 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 279010009440 Walker A/P-loop; other site 279010009441 ATP binding site [chemical binding]; other site 279010009442 Q-loop/lid; other site 279010009443 ABC transporter signature motif; other site 279010009444 Walker B; other site 279010009445 D-loop; other site 279010009446 H-loop/switch region; other site 279010009447 NIL domain; Region: NIL; cl09633 279010009448 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279010009449 catalytic residues [active] 279010009450 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279010009451 putative active site [active] 279010009452 putative metal binding site [ion binding]; other site 279010009453 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 279010009454 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 279010009455 lipoyl attachment site [posttranslational modification]; other site 279010009456 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 279010009457 ArsC family; Region: ArsC; pfam03960 279010009458 putative ArsC-like catalytic residues; other site 279010009459 putative TRX-like catalytic residues [active] 279010009460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 279010009461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010009462 active site 279010009463 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 279010009464 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279010009465 dimer interface [polypeptide binding]; other site 279010009466 active site 279010009467 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 279010009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009469 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010009470 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010009471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279010009472 substrate binding site [chemical binding]; other site 279010009473 oxyanion hole (OAH) forming residues; other site 279010009474 trimer interface [polypeptide binding]; other site 279010009475 YuzL-like protein; Region: YuzL; pfam14115 279010009476 Coat F domain; Region: Coat_F; cl15836 279010009477 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 279010009478 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 279010009479 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279010009480 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 279010009481 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010009482 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010009483 Walker A/P-loop; other site 279010009484 ATP binding site [chemical binding]; other site 279010009485 Q-loop/lid; other site 279010009486 ABC transporter signature motif; other site 279010009487 Walker B; other site 279010009488 D-loop; other site 279010009489 H-loop/switch region; other site 279010009490 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010009491 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009492 ABC-ATPase subunit interface; other site 279010009493 dimer interface [polypeptide binding]; other site 279010009494 putative PBP binding regions; other site 279010009495 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010009496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009497 ABC-ATPase subunit interface; other site 279010009498 dimer interface [polypeptide binding]; other site 279010009499 putative PBP binding regions; other site 279010009500 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010009501 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010009502 siderophore binding site; other site 279010009503 YusW-like protein; Region: YusW; pfam14039 279010009504 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 279010009505 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 279010009506 active site 279010009507 Zn binding site [ion binding]; other site 279010009508 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 279010009509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010009510 short chain dehydrogenase; Provisional; Region: PRK06914 279010009511 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 279010009512 NADP binding site [chemical binding]; other site 279010009513 active site 279010009514 steroid binding site; other site 279010009515 Ferritin-like domain; Region: Ferritin; pfam00210 279010009516 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 279010009517 dimerization interface [polypeptide binding]; other site 279010009518 DPS ferroxidase diiron center [ion binding]; other site 279010009519 ion pore; other site 279010009520 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 279010009521 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010009522 protein binding site [polypeptide binding]; other site 279010009523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010009524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009525 active site 279010009526 phosphorylation site [posttranslational modification] 279010009527 intermolecular recognition site; other site 279010009528 dimerization interface [polypeptide binding]; other site 279010009529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010009530 DNA binding site [nucleotide binding] 279010009531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009532 dimerization interface [polypeptide binding]; other site 279010009533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010009534 dimer interface [polypeptide binding]; other site 279010009535 phosphorylation site [posttranslational modification] 279010009536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009537 ATP binding site [chemical binding]; other site 279010009538 Mg2+ binding site [ion binding]; other site 279010009539 G-X-G motif; other site 279010009540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279010009541 Helix-turn-helix domains; Region: HTH; cl00088 279010009542 fumarate hydratase; Reviewed; Region: fumC; PRK00485 279010009543 Class II fumarases; Region: Fumarase_classII; cd01362 279010009544 active site 279010009545 tetramer interface [polypeptide binding]; other site 279010009546 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 279010009547 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 279010009548 Spore germination protein; Region: Spore_permease; cl15802 279010009549 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 279010009550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010009551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009552 active site 279010009553 phosphorylation site [posttranslational modification] 279010009554 intermolecular recognition site; other site 279010009555 dimerization interface [polypeptide binding]; other site 279010009556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010009557 DNA binding residues [nucleotide binding] 279010009558 dimerization interface [polypeptide binding]; other site 279010009559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010009560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010009561 dimerization interface [polypeptide binding]; other site 279010009562 Histidine kinase; Region: HisKA_3; pfam07730 279010009563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 279010009564 Predicted membrane protein [Function unknown]; Region: COG4758 279010009565 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 279010009566 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 279010009567 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010009568 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010009569 Interleukin 10; Region: IL10; cl02501 279010009570 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 279010009571 Pectinesterase; Region: Pectinesterase; cl01911 279010009572 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 279010009573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010009574 classical (c) SDRs; Region: SDR_c; cd05233 279010009575 NAD(P) binding site [chemical binding]; other site 279010009576 active site 279010009577 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 279010009578 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 279010009579 putative active site [active] 279010009580 metal binding site [ion binding]; metal-binding site 279010009581 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010009582 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 279010009583 inhibitor site; inhibition site 279010009584 active site 279010009585 dimer interface [polypeptide binding]; other site 279010009586 catalytic residue [active] 279010009587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010009588 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010009589 Walker A/P-loop; other site 279010009590 ATP binding site [chemical binding]; other site 279010009591 Q-loop/lid; other site 279010009592 ABC transporter signature motif; other site 279010009593 Walker B; other site 279010009594 D-loop; other site 279010009595 H-loop/switch region; other site 279010009596 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009597 ABC-ATPase subunit interface; other site 279010009598 dimer interface [polypeptide binding]; other site 279010009599 putative PBP binding regions; other site 279010009600 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279010009601 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 279010009602 putative binding site residues; other site 279010009603 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010009604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010009605 DNA-binding site [nucleotide binding]; DNA binding site 279010009606 FCD domain; Region: FCD; cl11656 279010009607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010009608 classical (c) SDRs; Region: SDR_c; cd05233 279010009609 NAD(P) binding site [chemical binding]; other site 279010009610 active site 279010009611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 279010009612 MOSC domain; Region: MOSC; pfam03473 279010009613 3-alpha domain; Region: 3-alpha; pfam03475 279010009614 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 279010009615 Helix-turn-helix domains; Region: HTH; cl00088 279010009616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279010009617 dimerization interface [polypeptide binding]; other site 279010009618 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 279010009619 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 279010009620 SAF domain; Region: SAF; cl00555 279010009621 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 279010009622 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 279010009623 altronate oxidoreductase; Provisional; Region: PRK03643 279010009624 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 279010009625 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 279010009626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010009627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010009628 DNA binding site [nucleotide binding] 279010009629 domain linker motif; other site 279010009630 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279010009631 dimerization interface [polypeptide binding]; other site 279010009632 ligand binding site [chemical binding]; other site 279010009633 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 279010009634 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 279010009635 Glucuronate isomerase; Region: UxaC; cl00829 279010009636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010009637 dimer interface [polypeptide binding]; other site 279010009638 phosphorylation site [posttranslational modification] 279010009639 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 279010009640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010009641 ATP binding site [chemical binding]; other site 279010009642 Mg2+ binding site [ion binding]; other site 279010009643 G-X-G motif; other site 279010009644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010009645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010009646 active site 279010009647 phosphorylation site [posttranslational modification] 279010009648 intermolecular recognition site; other site 279010009649 dimerization interface [polypeptide binding]; other site 279010009650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010009651 DNA binding site [nucleotide binding] 279010009652 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279010009653 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279010009654 Walker A/P-loop; other site 279010009655 ATP binding site [chemical binding]; other site 279010009656 Q-loop/lid; other site 279010009657 ABC transporter signature motif; other site 279010009658 Walker B; other site 279010009659 D-loop; other site 279010009660 H-loop/switch region; other site 279010009661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009662 ABC-ATPase subunit interface; other site 279010009663 dimer interface [polypeptide binding]; other site 279010009664 putative PBP binding regions; other site 279010009665 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010009666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009667 ABC-ATPase subunit interface; other site 279010009668 dimer interface [polypeptide binding]; other site 279010009669 putative PBP binding regions; other site 279010009670 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 279010009671 Spore germination protein; Region: Spore_permease; cl15802 279010009672 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 279010009673 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 279010009674 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010009675 Sulfatase; Region: Sulfatase; cl10460 279010009676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010009678 putative substrate translocation pore; other site 279010009679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009680 putative substrate translocation pore; other site 279010009681 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010009682 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279010009683 active site 279010009684 catalytic tetrad [active] 279010009685 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010009686 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 279010009687 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279010009688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279010009689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279010009690 catalytic residue [active] 279010009691 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 279010009692 Family description; Region: UvrD_C_2; cl15862 279010009693 Predicted membrane protein [Function unknown]; Region: COG2860 279010009694 UPF0126 domain; Region: UPF0126; pfam03458 279010009695 UPF0126 domain; Region: UPF0126; pfam03458 279010009696 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 279010009697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279010009698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010009699 Coenzyme A binding pocket [chemical binding]; other site 279010009700 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 279010009701 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 279010009702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010009703 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010009704 metal-binding site [ion binding] 279010009705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010009706 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010009707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010009708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010009709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009710 dimer interface [polypeptide binding]; other site 279010009711 conserved gate region; other site 279010009712 putative PBP binding loops; other site 279010009713 ABC-ATPase subunit interface; other site 279010009714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010009715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009716 dimer interface [polypeptide binding]; other site 279010009717 conserved gate region; other site 279010009718 putative PBP binding loops; other site 279010009719 ABC-ATPase subunit interface; other site 279010009720 putative alpha-glucosidase; Provisional; Region: PRK10658 279010009721 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 279010009722 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 279010009723 active site 279010009724 homotrimer interface [polypeptide binding]; other site 279010009725 catalytic site [active] 279010009726 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 279010009727 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 279010009728 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 279010009729 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 279010009730 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 279010009731 PKC phosphorylation site [posttranslational modification]; other site 279010009732 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 279010009733 Fibronectin type III-like domain; Region: Fn3-like; cl15273 279010009734 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 279010009735 metal binding site [ion binding]; metal-binding site 279010009736 ligand binding site [chemical binding]; other site 279010009737 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279010009738 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 279010009739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010009740 dimer interface [polypeptide binding]; other site 279010009741 ABC-ATPase subunit interface; other site 279010009742 putative PBP binding regions; other site 279010009743 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 279010009744 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 279010009745 metal binding site [ion binding]; metal-binding site 279010009746 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279010009747 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279010009748 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279010009749 putative active site [active] 279010009750 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 279010009751 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279010009752 putative substrate binding site [chemical binding]; other site 279010009753 putative ATP binding site [chemical binding]; other site 279010009754 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 279010009755 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279010009756 P-loop; other site 279010009757 active site 279010009758 phosphorylation site [posttranslational modification] 279010009759 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010009760 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010009761 active site 279010009762 phosphorylation site [posttranslational modification] 279010009763 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010009764 hypothetical protein; Provisional; Region: PRK08185 279010009765 intersubunit interface [polypeptide binding]; other site 279010009766 active site 279010009767 zinc binding site [ion binding]; other site 279010009768 Na+ binding site [ion binding]; other site 279010009769 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010009770 metal-binding site [ion binding] 279010009771 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279010009772 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010009773 metal-binding site [ion binding] 279010009774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279010009775 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010009776 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279010009777 metal-binding site [ion binding] 279010009778 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 279010009779 putative homotetramer interface [polypeptide binding]; other site 279010009780 putative homodimer interface [polypeptide binding]; other site 279010009781 allosteric switch controlling residues; other site 279010009782 putative metal binding site [ion binding]; other site 279010009783 putative homodimer-homodimer interface [polypeptide binding]; other site 279010009784 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279010009785 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 279010009786 conserved cys residue [active] 279010009787 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010009788 Helix-turn-helix domains; Region: HTH; cl00088 279010009789 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010009790 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 279010009791 N- and C-terminal domain interface [polypeptide binding]; other site 279010009792 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 279010009793 active site 279010009794 catalytic site [active] 279010009795 metal binding site [ion binding]; metal-binding site 279010009796 ATP binding site [chemical binding]; other site 279010009797 carbohydrate binding site [chemical binding]; other site 279010009798 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 279010009799 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 279010009800 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 279010009801 short chain dehydrogenase; Validated; Region: PRK08324 279010009802 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 279010009803 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 279010009804 putative NAD(P) binding site [chemical binding]; other site 279010009805 active site 279010009806 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010009807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009808 putative substrate translocation pore; other site 279010009809 similar to hypothetical protein; RBL05144 279010009810 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279010009811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010009812 putative substrate translocation pore; other site 279010009813 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 279010009814 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 279010009815 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010009816 Helix-turn-helix domains; Region: HTH; cl00088 279010009817 Amidase; Region: Amidase; cl11426 279010009818 Amidase; Region: Amidase; cl11426 279010009819 putative oxidoreductase; Provisional; Region: PRK11579 279010009820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010009822 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010009823 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 279010009824 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 279010009825 active site residue [active] 279010009826 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 279010009827 hypothetical protein; Provisional; Region: PRK14082 279010009828 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010009829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010009830 DNA binding residues [nucleotide binding] 279010009831 YvrJ protein family; Region: YvrJ; pfam12841 279010009832 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 279010009833 Cupin domain; Region: Cupin_2; cl09118 279010009834 Cupin domain; Region: Cupin_2; cl09118 279010009835 Regulatory protein YrvL; Region: YrvL; pfam14184 279010009836 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010009837 Helix-turn-helix domains; Region: HTH; cl00088 279010009838 putative transposase OrfB; Reviewed; Region: PHA02517 279010009839 Integrase core domain; Region: rve; cl01316 279010009840 Helix-turn-helix domains; Region: HTH; cl00088 279010009841 Helix-turn-helix domains; Region: HTH; cl00088 279010009842 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 279010009843 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010009844 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 279010009845 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279010009846 amidase catalytic site [active] 279010009847 Zn binding residues [ion binding]; other site 279010009848 substrate binding site [chemical binding]; other site 279010009849 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010009850 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010009851 Phage lysis protein, holin; Region: Phage_holin; cl04675 279010009852 Haemolysin XhlA; Region: XhlA; pfam10779 279010009853 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279010009854 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279010009855 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 279010009856 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 279010009857 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 279010009858 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 279010009859 Phage tail protein; Region: Sipho_tail; pfam05709 279010009860 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 279010009861 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 279010009862 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279010009863 catalytic residue [active] 279010009864 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 279010009865 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 279010009866 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 279010009867 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 279010009868 oligomerization interface [polypeptide binding]; other site 279010009869 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 279010009870 Phage capsid family; Region: Phage_capsid; pfam05065 279010009871 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 279010009872 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 279010009873 oligomer interface [polypeptide binding]; other site 279010009874 active site residues [active] 279010009875 Phage portal protein; Region: Phage_portal; pfam04860 279010009876 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279010009877 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 279010009878 Phage Terminase; Region: Terminase_1; pfam03354 279010009879 Phage terminase, small subunit; Region: Terminase_4; cl01525 279010009880 similar to hypothetical protein; RBL05822 279010009881 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 279010009882 ERCC4 domain; Region: ERCC4; cl10594 279010009883 Uncharacterized conserved protein [Function unknown]; Region: COG4983 279010009884 hypothetical protein; Provisional; Region: PRK14709 279010009885 D5 N terminal like; Region: D5_N; cl07360 279010009886 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 279010009887 Protein of unknown function (DUF669); Region: DUF669; pfam05037 279010009888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010009889 Walker A/P-loop; other site 279010009890 ATP binding site [chemical binding]; other site 279010009891 Q-loop/lid; other site 279010009892 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 279010009893 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 279010009894 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 279010009895 ORF6N domain; Region: ORF6N; pfam10543 279010009896 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 279010009897 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279010009898 Int/Topo IB signature motif; other site 279010009899 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 279010009900 SmpB-tmRNA interface; other site 279010009901 ribonuclease R; Region: RNase_R; TIGR02063 279010009902 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010009903 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279010009904 RNB domain; Region: RNB; pfam00773 279010009905 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 279010009906 RNA binding site [nucleotide binding]; other site 279010009907 Esterase/lipase [General function prediction only]; Region: COG1647 279010009908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010009909 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 279010009910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010009911 salt bridge; other site 279010009912 non-specific DNA binding site [nucleotide binding]; other site 279010009913 sequence-specific DNA binding site [nucleotide binding]; other site 279010009914 transcriptional repressor DicA; Reviewed; Region: PRK09706 279010009915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010009916 non-specific DNA binding site [nucleotide binding]; other site 279010009917 salt bridge; other site 279010009918 sequence-specific DNA binding site [nucleotide binding]; other site 279010009919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010009920 non-specific DNA binding site [nucleotide binding]; other site 279010009921 salt bridge; other site 279010009922 sequence-specific DNA binding site [nucleotide binding]; other site 279010009923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009924 dimer interface [polypeptide binding]; other site 279010009925 conserved gate region; other site 279010009926 putative PBP binding loops; other site 279010009927 ABC-ATPase subunit interface; other site 279010009928 NMT1-like family; Region: NMT1_2; cl15260 279010009929 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279010009930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010009931 dimer interface [polypeptide binding]; other site 279010009932 conserved gate region; other site 279010009933 ABC-ATPase subunit interface; other site 279010009934 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 279010009935 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 279010009936 Walker A/P-loop; other site 279010009937 ATP binding site [chemical binding]; other site 279010009938 Q-loop/lid; other site 279010009939 ABC transporter signature motif; other site 279010009940 Walker B; other site 279010009941 D-loop; other site 279010009942 H-loop/switch region; other site 279010009943 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 279010009944 Predicted transcriptional regulators [Transcription]; Region: COG1510 279010009945 Helix-turn-helix domains; Region: HTH; cl00088 279010009946 MarC family integral membrane protein; Region: MarC; cl00919 279010009947 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 279010009948 Predicted membrane protein [Function unknown]; Region: COG4640 279010009949 Predicted membrane protein [Function unknown]; Region: COG4640 279010009950 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 279010009951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010009952 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279010009953 siderophore binding site; other site 279010009954 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 279010009955 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 279010009956 enolase; Provisional; Region: eno; PRK00077 279010009957 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 279010009958 dimer interface [polypeptide binding]; other site 279010009959 metal binding site [ion binding]; metal-binding site 279010009960 substrate binding pocket [chemical binding]; other site 279010009961 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 279010009962 Sulfatase; Region: Sulfatase; cl10460 279010009963 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 279010009964 substrate binding site [chemical binding]; other site 279010009965 dimer interface [polypeptide binding]; other site 279010009966 catalytic triad [active] 279010009967 Phosphoglycerate kinase; Region: PGK; pfam00162 279010009968 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 279010009969 substrate binding site [chemical binding]; other site 279010009970 hinge regions; other site 279010009971 ADP binding site [chemical binding]; other site 279010009972 catalytic site [active] 279010009973 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 279010009974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010009975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 279010009976 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010009977 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010009978 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279010009979 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 279010009980 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279010009981 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010009982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010009983 Walker A/P-loop; other site 279010009984 ATP binding site [chemical binding]; other site 279010009985 Q-loop/lid; other site 279010009986 ABC transporter signature motif; other site 279010009987 Walker B; other site 279010009988 D-loop; other site 279010009989 H-loop/switch region; other site 279010009990 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010009991 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010009992 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 279010009993 iron-sulfur cluster-binding protein; Region: TIGR00273 279010009994 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 279010009995 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 279010009996 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 279010009997 Cysteine-rich domain; Region: CCG; pfam02754 279010009998 Cysteine-rich domain; Region: CCG; pfam02754 279010009999 Transcriptional regulators [Transcription]; Region: FadR; COG2186 279010010000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010010001 DNA-binding site [nucleotide binding]; DNA binding site 279010010002 FCD domain; Region: FCD; cl11656 279010010003 glycolate transporter; Provisional; Region: PRK09695 279010010004 L-lactate permease; Region: Lactate_perm; cl00701 279010010005 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 279010010006 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 279010010007 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 279010010008 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 279010010009 YvfG protein; Region: YvfG; pfam09628 279010010010 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 279010010011 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 279010010012 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010010013 inhibitor-cofactor binding pocket; inhibition site 279010010014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010010015 catalytic residue [active] 279010010016 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 279010010017 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 279010010018 putative trimer interface [polypeptide binding]; other site 279010010019 putative CoA binding site [chemical binding]; other site 279010010020 Bacterial sugar transferase; Region: Bac_transf; cl00939 279010010021 MatE; Region: MatE; cl10513 279010010022 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 279010010023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010010024 active site 279010010025 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 279010010026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 279010010027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010010028 active site 279010010029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010030 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 279010010031 putative ADP-binding pocket [chemical binding]; other site 279010010032 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010010033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 279010010034 active site 279010010035 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 279010010036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010037 putative ADP-binding pocket [chemical binding]; other site 279010010038 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 279010010039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010040 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279010010041 NAD(P) binding site [chemical binding]; other site 279010010042 homodimer interface [polypeptide binding]; other site 279010010043 substrate binding site [chemical binding]; other site 279010010044 active site 279010010045 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 279010010046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010010047 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 279010010048 Chain length determinant protein; Region: Wzz; cl15801 279010010049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279010010050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010010051 non-specific DNA binding site [nucleotide binding]; other site 279010010052 salt bridge; other site 279010010053 sequence-specific DNA binding site [nucleotide binding]; other site 279010010054 Anti-repressor SinI; Region: SinI; pfam08671 279010010055 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010010056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010057 D-galactonate transporter; Region: 2A0114; TIGR00893 279010010058 putative substrate translocation pore; other site 279010010059 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 279010010060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010061 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 279010010062 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 279010010063 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 279010010064 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 279010010065 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 279010010066 putative active site [active] 279010010067 metal binding site [ion binding]; metal-binding site 279010010068 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279010010069 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 279010010070 inhibitor site; inhibition site 279010010071 active site 279010010072 dimer interface [polypeptide binding]; other site 279010010073 catalytic residue [active] 279010010074 Propionate catabolism activator; Region: PrpR_N; pfam06506 279010010075 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 279010010076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010010077 Helix-turn-helix domains; Region: HTH; cl00088 279010010078 Helix-turn-helix domains; Region: HTH; cl00088 279010010079 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 279010010080 putative active site [active] 279010010081 putative FMN binding site [chemical binding]; other site 279010010082 putative substrate binding site [chemical binding]; other site 279010010083 putative catalytic residue [active] 279010010084 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 279010010085 active site 279010010086 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 279010010087 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010010088 substrate binding [chemical binding]; other site 279010010089 active site 279010010090 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010010091 TM2 domain; Region: TM2; cl00984 279010010092 Clp protease; Region: CLP_protease; pfam00574 279010010093 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 279010010094 oligomer interface [polypeptide binding]; other site 279010010095 active site residues [active] 279010010096 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 279010010097 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 279010010098 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 279010010099 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010010100 putative transporter; Provisional; Region: PRK11660 279010010101 Sulfate transporter family; Region: Sulfate_transp; cl15842 279010010102 Sulfate transporter family; Region: Sulfate_transp; cl15842 279010010103 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 279010010104 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 279010010105 active site clefts [active] 279010010106 zinc binding site [ion binding]; other site 279010010107 dimer interface [polypeptide binding]; other site 279010010108 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 279010010109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010110 Flavin Reductases; Region: FlaRed; cl00801 279010010111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279010010112 dimerization interface [polypeptide binding]; other site 279010010113 putative DNA binding site [nucleotide binding]; other site 279010010114 putative Zn2+ binding site [ion binding]; other site 279010010115 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 279010010116 active site 279010010117 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 279010010118 RNAase interaction site [polypeptide binding]; other site 279010010119 N-acetyltransferase; Region: Acetyltransf_2; cl00949 279010010120 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279010010121 dimerization domain swap beta strand [polypeptide binding]; other site 279010010122 regulatory protein interface [polypeptide binding]; other site 279010010123 active site 279010010124 regulatory phosphorylation site [posttranslational modification]; other site 279010010125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 279010010126 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 279010010127 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 279010010128 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 279010010129 phosphate binding site [ion binding]; other site 279010010130 putative substrate binding pocket [chemical binding]; other site 279010010131 dimer interface [polypeptide binding]; other site 279010010132 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 279010010133 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 279010010134 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 279010010135 putative active site [active] 279010010136 nucleotide binding site [chemical binding]; other site 279010010137 nudix motif; other site 279010010138 putative metal binding site [ion binding]; other site 279010010139 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 279010010140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010010142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279010010143 binding surface 279010010144 TPR motif; other site 279010010145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010010146 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010010147 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 279010010148 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 279010010149 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 279010010150 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 279010010151 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 279010010152 substrate binding site [chemical binding]; other site 279010010153 glutamase interaction surface [polypeptide binding]; other site 279010010154 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 279010010155 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 279010010156 catalytic residues [active] 279010010157 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 279010010158 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 279010010159 putative active site [active] 279010010160 oxyanion strand; other site 279010010161 catalytic triad [active] 279010010162 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 279010010163 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 279010010164 putative active site pocket [active] 279010010165 4-fold oligomerization interface [polypeptide binding]; other site 279010010166 metal binding residues [ion binding]; metal-binding site 279010010167 3-fold/trimer interface [polypeptide binding]; other site 279010010168 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 279010010169 histidinol dehydrogenase; Region: hisD; TIGR00069 279010010170 NAD binding site [chemical binding]; other site 279010010171 dimerization interface [polypeptide binding]; other site 279010010172 product binding site; other site 279010010173 substrate binding site [chemical binding]; other site 279010010174 zinc binding site [ion binding]; other site 279010010175 catalytic residues [active] 279010010176 ATP phosphoribosyltransferase; Region: HisG; cl15266 279010010177 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 279010010178 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 279010010179 dimer interface [polypeptide binding]; other site 279010010180 motif 1; other site 279010010181 active site 279010010182 motif 2; other site 279010010183 motif 3; other site 279010010184 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 279010010185 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 279010010186 putative active site [active] 279010010187 Pectate lyase; Region: Pectate_lyase; pfam03211 279010010188 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 279010010189 trimer interface [polypeptide binding]; other site 279010010190 active site 279010010191 substrate binding site [chemical binding]; other site 279010010192 CoA binding site [chemical binding]; other site 279010010193 pyrophosphatase PpaX; Provisional; Region: PRK13288 279010010194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010195 active site 279010010196 motif I; other site 279010010197 motif II; other site 279010010198 Nucleoside recognition; Region: Gate; cl00486 279010010199 Nucleoside recognition; Region: Gate; cl00486 279010010200 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 279010010201 HPr kinase/phosphorylase; Provisional; Region: PRK05428 279010010202 DRTGG domain; Region: DRTGG; cl12147 279010010203 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 279010010204 Hpr binding site; other site 279010010205 active site 279010010206 homohexamer subunit interaction site [polypeptide binding]; other site 279010010207 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010010208 Helix-turn-helix domains; Region: HTH; cl00088 279010010209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010010211 putative substrate translocation pore; other site 279010010212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010213 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 279010010214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279010010215 putative active site [active] 279010010216 putative metal binding site [ion binding]; other site 279010010217 Membrane protein of unknown function; Region: DUF360; cl00850 279010010218 PspC domain; Region: PspC; cl00864 279010010219 Uncharacterized conserved protein [Function unknown]; Region: COG3595 279010010220 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279010010221 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010010222 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279010010223 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 279010010224 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 279010010225 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 279010010226 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 279010010227 excinuclease ABC subunit B; Provisional; Region: PRK05298 279010010228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010010229 ATP binding site [chemical binding]; other site 279010010230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010231 nucleotide binding region [chemical binding]; other site 279010010232 ATP-binding site [chemical binding]; other site 279010010233 Ultra-violet resistance protein B; Region: UvrB; pfam12344 279010010234 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 279010010235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010010236 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 279010010237 C-terminal peptidase (prc); Region: prc; TIGR00225 279010010238 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 279010010239 protein binding site [polypeptide binding]; other site 279010010240 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 279010010241 Catalytic dyad [active] 279010010242 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 279010010243 tartrate dehydrogenase; Provisional; Region: PRK08194 279010010244 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 279010010245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 279010010246 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010010247 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 279010010248 FtsX-like permease family; Region: FtsX; cl15850 279010010249 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 279010010250 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 279010010251 Walker A/P-loop; other site 279010010252 ATP binding site [chemical binding]; other site 279010010253 Q-loop/lid; other site 279010010254 ABC transporter signature motif; other site 279010010255 Walker B; other site 279010010256 D-loop; other site 279010010257 H-loop/switch region; other site 279010010258 Cytochrome c; Region: Cytochrom_C; cl11414 279010010259 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279010010260 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010010261 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010010262 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010010263 peptide chain release factor 2; Provisional; Region: PRK06746 279010010264 RF-1 domain; Region: RF-1; cl02875 279010010265 RF-1 domain; Region: RF-1; cl02875 279010010266 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 279010010267 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 279010010268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010269 nucleotide binding region [chemical binding]; other site 279010010270 ATP-binding site [chemical binding]; other site 279010010271 SEC-C motif; Region: SEC-C; pfam02810 279010010272 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 279010010273 30S subunit binding site; other site 279010010274 Flagellar protein FliT; Region: FliT; cl05125 279010010275 Flagellar protein FliS; Region: FliS; cl00654 279010010276 flagellar capping protein; Validated; Region: fliD; PRK07737 279010010277 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 279010010278 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 279010010279 FlaG protein; Region: FlaG; cl00591 279010010280 flagellin; Provisional; Region: PRK12804 279010010281 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 279010010282 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 279010010283 Global regulator protein family; Region: CsrA; cl00670 279010010284 FliW protein; Region: FliW; cl00740 279010010285 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 279010010286 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 279010010287 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 279010010288 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 279010010289 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010010290 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 279010010291 FlgN protein; Region: FlgN; cl09176 279010010292 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 279010010293 flagellar operon protein TIGR03826; Region: YvyF 279010010294 comF family protein; Region: comF; TIGR00201 279010010295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010010296 active site 279010010297 Late competence development protein ComFB; Region: ComFB; pfam10719 279010010298 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 279010010299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010010300 ATP binding site [chemical binding]; other site 279010010301 putative Mg++ binding site [ion binding]; other site 279010010302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010303 nucleotide binding region [chemical binding]; other site 279010010304 ATP-binding site [chemical binding]; other site 279010010305 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 279010010306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010010307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010010308 active site 279010010309 phosphorylation site [posttranslational modification] 279010010310 intermolecular recognition site; other site 279010010311 dimerization interface [polypeptide binding]; other site 279010010312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010010313 DNA binding residues [nucleotide binding] 279010010314 dimerization interface [polypeptide binding]; other site 279010010315 Sensor protein DegS; Region: DegS; pfam05384 279010010316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 279010010317 Histidine kinase; Region: HisKA_3; pfam07730 279010010318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010010319 ATP binding site [chemical binding]; other site 279010010320 Mg2+ binding site [ion binding]; other site 279010010321 G-X-G motif; other site 279010010322 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 279010010323 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 279010010324 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 279010010325 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010010326 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 279010010327 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 279010010328 Mg++ binding site [ion binding]; other site 279010010329 putative catalytic motif [active] 279010010330 substrate binding site [chemical binding]; other site 279010010331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 279010010332 putative homodimer interface [polypeptide binding]; other site 279010010333 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 279010010334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 279010010335 active site 279010010336 O-Antigen ligase; Region: Wzy_C; cl04850 279010010337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279010010338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010339 NAD(P) binding site [chemical binding]; other site 279010010340 active site 279010010341 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 279010010342 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 279010010343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279010010345 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 279010010346 colanic acid exporter; Provisional; Region: PRK10459 279010010347 MatE; Region: MatE; cl10513 279010010348 Bacterial sugar transferase; Region: Bac_transf; cl00939 279010010349 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010350 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 279010010351 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010352 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010353 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279010010354 active site 279010010355 metal binding site [ion binding]; metal-binding site 279010010356 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010357 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 279010010358 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010359 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 279010010360 Stage II sporulation protein; Region: SpoIID; pfam08486 279010010361 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 279010010362 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010010363 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 279010010364 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 279010010365 active site 279010010366 homodimer interface [polypeptide binding]; other site 279010010367 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 279010010368 active site 279010010369 tetramer interface; other site 279010010370 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 279010010371 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 279010010372 Walker A/P-loop; other site 279010010373 ATP binding site [chemical binding]; other site 279010010374 Q-loop/lid; other site 279010010375 ABC transporter signature motif; other site 279010010376 Walker B; other site 279010010377 D-loop; other site 279010010378 H-loop/switch region; other site 279010010379 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010010380 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010381 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010010382 SH3-like domain; Region: SH3_8; pfam13457 279010010383 SH3-like domain; Region: SH3_8; pfam13457 279010010384 SH3-like domain; Region: SH3_8; pfam13457 279010010385 SH3-like domain; Region: SH3_8; pfam13457 279010010386 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 279010010387 putative ADP-binding pocket [chemical binding]; other site 279010010388 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010389 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 279010010390 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 279010010391 active site 279010010392 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 279010010393 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279010010394 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279010010395 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279010010396 Bacterial SH3 domain; Region: SH3_3; cl02551 279010010397 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 279010010398 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 279010010399 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 279010010400 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 279010010401 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 279010010402 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 279010010403 Class III ribonucleotide reductase; Region: RNR_III; cd01675 279010010404 effector binding site; other site 279010010405 active site 279010010406 Zn binding site [ion binding]; other site 279010010407 glycine loop; other site 279010010408 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 279010010409 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 279010010410 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 279010010411 active site 279010010412 intersubunit interface [polypeptide binding]; other site 279010010413 catalytic residue [active] 279010010414 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010010415 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010010416 substrate binding site [chemical binding]; other site 279010010417 ATP binding site [chemical binding]; other site 279010010418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010420 DNA binding site [nucleotide binding] 279010010421 domain linker motif; other site 279010010422 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 279010010423 putative dimerization interface [polypeptide binding]; other site 279010010424 putative ligand binding site [chemical binding]; other site 279010010425 KduI/IolB family; Region: KduI; cl01508 279010010426 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 279010010427 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 279010010428 NADP binding site [chemical binding]; other site 279010010429 homodimer interface [polypeptide binding]; other site 279010010430 active site 279010010431 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 279010010432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279010010433 NAD binding site [chemical binding]; other site 279010010434 catalytic Zn binding site [ion binding]; other site 279010010435 structural Zn binding site [ion binding]; other site 279010010436 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279010010437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010438 putative substrate translocation pore; other site 279010010439 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279010010440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010441 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010010442 active site 279010010443 motif I; other site 279010010444 motif II; other site 279010010445 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010010446 NlpC/P60 family; Region: NLPC_P60; cl11438 279010010447 NlpC/P60 family; Region: NLPC_P60; cl11438 279010010448 NlpC/P60 family; Region: NLPC_P60; cl11438 279010010449 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 279010010450 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 279010010451 putative active site [active] 279010010452 putative metal binding site [ion binding]; other site 279010010453 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 279010010454 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 279010010455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279010010456 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010458 DNA binding site [nucleotide binding] 279010010459 domain linker motif; other site 279010010460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 279010010461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010010462 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 279010010463 substrate binding site [chemical binding]; other site 279010010464 dimer interface [polypeptide binding]; other site 279010010465 ATP binding site [chemical binding]; other site 279010010466 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 279010010467 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 279010010468 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 279010010469 Walker A/P-loop; other site 279010010470 ATP binding site [chemical binding]; other site 279010010471 Q-loop/lid; other site 279010010472 ABC transporter signature motif; other site 279010010473 Walker B; other site 279010010474 D-loop; other site 279010010475 H-loop/switch region; other site 279010010476 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 279010010477 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 279010010478 TM-ABC transporter signature motif; other site 279010010479 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 279010010480 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 279010010481 ligand binding site [chemical binding]; other site 279010010482 dimerization interface [polypeptide binding]; other site 279010010483 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 279010010484 acetolactate synthase; Reviewed; Region: PRK08617 279010010485 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010010486 PYR/PP interface [polypeptide binding]; other site 279010010487 dimer interface [polypeptide binding]; other site 279010010488 TPP binding site [chemical binding]; other site 279010010489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 279010010490 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 279010010491 TPP-binding site [chemical binding]; other site 279010010492 dimer interface [polypeptide binding]; other site 279010010493 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 279010010494 Helix-turn-helix domains; Region: HTH; cl00088 279010010495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010010496 dimerization interface [polypeptide binding]; other site 279010010497 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 279010010498 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 279010010499 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 279010010500 Helix-turn-helix domains; Region: HTH; cl00088 279010010501 Chromate transporter; Region: Chromate_transp; pfam02417 279010010502 Chromate transporter; Region: Chromate_transp; pfam02417 279010010503 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 279010010504 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 279010010505 Chain length determinant protein; Region: Wzz; cl15801 279010010506 SNF2 Helicase protein; Region: DUF3670; pfam12419 279010010507 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 279010010508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010010509 ATP binding site [chemical binding]; other site 279010010510 putative Mg++ binding site [ion binding]; other site 279010010511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010010512 nucleotide binding region [chemical binding]; other site 279010010513 ATP-binding site [chemical binding]; other site 279010010514 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279010010515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010516 active site 279010010517 motif I; other site 279010010518 motif II; other site 279010010519 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010010520 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010010521 Helix-turn-helix domains; Region: HTH; cl00088 279010010522 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010010523 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 279010010524 catalytic residue [active] 279010010525 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 279010010526 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 279010010527 putative NAD(P) binding site [chemical binding]; other site 279010010528 active site 279010010529 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 279010010530 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 279010010531 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 279010010532 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 279010010533 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 279010010534 Glucitol operon activator protein (GutM); Region: GutM; cl01890 279010010535 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010010536 Helix-turn-helix domains; Region: HTH; cl00088 279010010537 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010010538 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010010539 dimer interface [polypeptide binding]; other site 279010010540 ssDNA binding site [nucleotide binding]; other site 279010010541 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010010542 YwpF-like protein; Region: YwpF; pfam14183 279010010543 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 279010010544 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 279010010545 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 279010010546 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 279010010547 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010010548 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 279010010549 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 279010010550 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 279010010551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 279010010552 rod shape-determining protein Mbl; Provisional; Region: PRK13928 279010010553 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 279010010554 ATP binding site [chemical binding]; other site 279010010555 profilin binding site; other site 279010010556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010010557 Helix-turn-helix domains; Region: HTH; cl00088 279010010558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010010559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010560 putative substrate translocation pore; other site 279010010561 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 279010010562 active site 279010010563 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 279010010564 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 279010010565 DHHA2 domain; Region: DHHA2; pfam02833 279010010566 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 279010010567 dimanganese center [ion binding]; other site 279010010568 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 279010010569 FOG: CBS domain [General function prediction only]; Region: COG0517 279010010570 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 279010010571 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 279010010572 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 279010010573 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279010010574 Domain of unknown function DUF21; Region: DUF21; pfam01595 279010010575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279010010576 Transporter associated domain; Region: CorC_HlyC; cl08393 279010010577 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 279010010578 Nitrogen regulatory protein P-II; Region: P-II; cl00412 279010010579 Nitrogen regulatory protein P-II; Region: P-II; smart00938 279010010580 Clp protease; Region: CLP_protease; pfam00574 279010010581 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 279010010582 oligomer interface [polypeptide binding]; other site 279010010583 active site residues [active] 279010010584 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279010010585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010010586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010010587 Peptidase family M23; Region: Peptidase_M23; pfam01551 279010010588 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279010010589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010010590 Coenzyme A binding pocket [chemical binding]; other site 279010010591 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 279010010592 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279010010593 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279010010594 putative active site [active] 279010010595 catalytic site [active] 279010010596 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279010010597 putative active site [active] 279010010598 catalytic site [active] 279010010599 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279010010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010601 putative substrate translocation pore; other site 279010010602 MbtH-like protein; Region: MbtH; cl01279 279010010603 peptide synthase; Provisional; Region: PRK12467 279010010604 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010605 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010606 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010010607 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 279010010608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 279010010609 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010610 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010611 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010010612 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 279010010613 hydrophobic substrate binding pocket; other site 279010010614 Isochorismatase family; Region: Isochorismatase; pfam00857 279010010615 active site 279010010616 conserved cis-peptide bond; other site 279010010617 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010010618 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 279010010619 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010620 AMP-binding enzyme; Region: AMP-binding; cl15778 279010010621 isochorismate synthase DhbC; Validated; Region: PRK06923 279010010622 chorismate binding enzyme; Region: Chorismate_bind; cl10555 279010010623 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 279010010624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010625 NAD(P) binding site [chemical binding]; other site 279010010626 active site 279010010627 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010010628 Putative esterase; Region: Esterase; pfam00756 279010010629 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279010010630 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010631 dimer interface [polypeptide binding]; other site 279010010632 putative PBP binding regions; other site 279010010633 ABC-ATPase subunit interface; other site 279010010634 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279010010635 ABC-ATPase subunit interface; other site 279010010636 dimer interface [polypeptide binding]; other site 279010010637 putative PBP binding regions; other site 279010010638 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010010639 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010010640 intersubunit interface [polypeptide binding]; other site 279010010641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010010642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279010010643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279010010644 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279010010645 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279010010646 intersubunit interface [polypeptide binding]; other site 279010010647 Helix-turn-helix domains; Region: HTH; cl00088 279010010648 putative transposase OrfB; Reviewed; Region: PHA02517 279010010649 Integrase core domain; Region: rve; cl01316 279010010650 Helix-turn-helix domains; Region: HTH; cl00088 279010010651 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 279010010652 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279010010653 NAD binding site [chemical binding]; other site 279010010654 substrate binding site [chemical binding]; other site 279010010655 putative active site [active] 279010010656 Predicted transcriptional regulator [Transcription]; Region: COG1959 279010010657 Helix-turn-helix domains; Region: HTH; cl00088 279010010658 GRAM domain; Region: GRAM; cl02671 279010010659 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 279010010660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010010661 FeS/SAM binding site; other site 279010010662 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 279010010663 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 279010010664 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 279010010665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010666 putative substrate translocation pore; other site 279010010667 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 279010010668 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 279010010669 putative molybdopterin cofactor binding site [chemical binding]; other site 279010010670 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 279010010671 molybdopterin cofactor binding site; other site 279010010672 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 279010010673 metal ion-dependent adhesion site (MIDAS); other site 279010010674 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 279010010675 metal ion-dependent adhesion site (MIDAS); other site 279010010676 stage II sporulation protein D; Region: spore_II_D; TIGR02870 279010010677 Stage II sporulation protein; Region: SpoIID; pfam08486 279010010678 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279010010679 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279010010680 hinge; other site 279010010681 active site 279010010682 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 279010010683 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 279010010684 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 279010010685 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 279010010686 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 279010010687 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 279010010688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 279010010689 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 279010010690 alpha subunit interaction interface [polypeptide binding]; other site 279010010691 Walker A motif; other site 279010010692 ATP binding site [chemical binding]; other site 279010010693 Walker B motif; other site 279010010694 inhibitor binding site; inhibition site 279010010695 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279010010696 ATP synthase; Region: ATP-synt; cl00365 279010010697 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 279010010698 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 279010010699 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 279010010700 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 279010010701 beta subunit interaction interface [polypeptide binding]; other site 279010010702 Walker A motif; other site 279010010703 ATP binding site [chemical binding]; other site 279010010704 Walker B motif; other site 279010010705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279010010706 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 279010010707 Plant ATP synthase F0; Region: YMF19; cl07975 279010010708 Plant ATP synthase F0; Region: YMF19; cl07975 279010010709 ATP synthase subunit C; Region: ATP-synt_C; cl00466 279010010710 ATP synthase A chain; Region: ATP-synt_A; cl00413 279010010711 ATP synthase I chain; Region: ATP_synt_I; cl09170 279010010712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279010010713 active site 279010010714 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 279010010715 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 279010010716 dimer interface [polypeptide binding]; other site 279010010717 glycine-pyridoxal phosphate binding site [chemical binding]; other site 279010010718 active site 279010010719 folate binding site [chemical binding]; other site 279010010720 Protein of unknown function (DUF436); Region: DUF436; cl01860 279010010721 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 279010010722 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279010010723 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 279010010724 active site 279010010725 Predicted membrane protein [Function unknown]; Region: COG1971 279010010726 Domain of unknown function DUF; Region: DUF204; pfam02659 279010010727 Domain of unknown function DUF; Region: DUF204; pfam02659 279010010728 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 279010010729 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 279010010730 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010010731 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 279010010732 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 279010010733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010734 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010010735 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 279010010736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010010737 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 279010010738 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279010010739 inhibitor-cofactor binding pocket; inhibition site 279010010740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010010741 catalytic residue [active] 279010010742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010010743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010010744 DNA binding site [nucleotide binding] 279010010745 domain linker motif; other site 279010010746 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 279010010747 putative ligand binding site [chemical binding]; other site 279010010748 putative dimerization interface [polypeptide binding]; other site 279010010749 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 279010010750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010010751 S-adenosylmethionine binding site [chemical binding]; other site 279010010752 peptide chain release factor 1; Validated; Region: prfA; PRK00591 279010010753 RF-1 domain; Region: RF-1; cl02875 279010010754 RF-1 domain; Region: RF-1; cl02875 279010010755 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 279010010756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010010757 putative metal binding site [ion binding]; other site 279010010758 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 279010010759 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 279010010760 DNA binding residues [nucleotide binding] 279010010761 Membrane transport protein; Region: Mem_trans; cl09117 279010010762 malate dehydrogenase; Provisional; Region: PRK13529 279010010763 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010010764 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 279010010765 NAD(P) binding site [chemical binding]; other site 279010010766 thymidine kinase; Provisional; Region: PRK04296 279010010767 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 279010010768 transcription termination factor Rho; Provisional; Region: rho; PRK09376 279010010769 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 279010010770 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 279010010771 RNA binding site [nucleotide binding]; other site 279010010772 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 279010010773 multimer interface [polypeptide binding]; other site 279010010774 Walker A motif; other site 279010010775 ATP binding site [chemical binding]; other site 279010010776 Walker B motif; other site 279010010777 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 279010010778 putative active site [active] 279010010779 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279010010780 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279010010781 hinge; other site 279010010782 active site 279010010783 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 279010010784 active site 279010010785 intersubunit interactions; other site 279010010786 catalytic residue [active] 279010010787 hypothetical protein; Provisional; Region: PRK08185 279010010788 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010010789 intersubunit interface [polypeptide binding]; other site 279010010790 active site 279010010791 zinc binding site [ion binding]; other site 279010010792 Na+ binding site [ion binding]; other site 279010010793 Response regulator receiver domain; Region: Response_reg; pfam00072 279010010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010010795 active site 279010010796 phosphorylation site [posttranslational modification] 279010010797 intermolecular recognition site; other site 279010010798 dimerization interface [polypeptide binding]; other site 279010010799 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 279010010800 CTP synthetase; Validated; Region: pyrG; PRK05380 279010010801 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 279010010802 Catalytic site [active] 279010010803 active site 279010010804 UTP binding site [chemical binding]; other site 279010010805 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 279010010806 active site 279010010807 putative oxyanion hole; other site 279010010808 catalytic triad [active] 279010010809 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 279010010810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010010811 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010010812 FAD binding site [chemical binding]; other site 279010010813 homotetramer interface [polypeptide binding]; other site 279010010814 substrate binding pocket [chemical binding]; other site 279010010815 catalytic base [active] 279010010816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279010010817 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 279010010818 FAD binding site [chemical binding]; other site 279010010819 homotetramer interface [polypeptide binding]; other site 279010010820 substrate binding pocket [chemical binding]; other site 279010010821 catalytic base [active] 279010010822 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 279010010823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010824 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 279010010825 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 279010010826 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279010010827 dimer interface [polypeptide binding]; other site 279010010828 active site 279010010829 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 279010010830 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 279010010831 Cysteine-rich domain; Region: CCG; pfam02754 279010010832 Cysteine-rich domain; Region: CCG; pfam02754 279010010833 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279010010834 PLD-like domain; Region: PLDc_2; pfam13091 279010010835 putative active site [active] 279010010836 catalytic site [active] 279010010837 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279010010838 PLD-like domain; Region: PLDc_2; pfam13091 279010010839 putative active site [active] 279010010840 catalytic site [active] 279010010841 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 279010010842 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 279010010843 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 279010010844 active site 279010010845 HIGH motif; other site 279010010846 KMSK motif region; other site 279010010847 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 279010010848 tRNA binding surface [nucleotide binding]; other site 279010010849 anticodon binding site; other site 279010010850 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 279010010851 Arginase family; Region: Arginase; cl00306 279010010852 spermidine synthase; Provisional; Region: PRK00811 279010010853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 279010010854 Transglycosylase; Region: Transgly; cl07896 279010010855 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279010010856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 279010010857 YwhD family; Region: YwhD; pfam08741 279010010858 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 279010010859 active site 279010010860 putative substrate binding region [chemical binding]; other site 279010010861 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 279010010862 active site 1 [active] 279010010863 dimer interface [polypeptide binding]; other site 279010010864 hexamer interface [polypeptide binding]; other site 279010010865 active site 2 [active] 279010010866 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 279010010867 Uncharacterized conserved protein [Function unknown]; Region: COG3465 279010010868 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 279010010869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 279010010870 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 279010010871 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 279010010872 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 279010010873 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 279010010874 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279010010875 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 279010010876 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 279010010877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010010879 benzoate transport; Region: 2A0115; TIGR00895 279010010880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010881 putative substrate translocation pore; other site 279010010882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010010883 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 279010010884 active site 279010010885 metal binding site [ion binding]; metal-binding site 279010010886 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 279010010887 active site 1 [active] 279010010888 dimer interface [polypeptide binding]; other site 279010010889 hexamer interface [polypeptide binding]; other site 279010010890 active site 2 [active] 279010010891 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 279010010892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010010893 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 279010010894 NAD binding site [chemical binding]; other site 279010010895 catalytic residues [active] 279010010896 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010010897 Helix-turn-helix domains; Region: HTH; cl00088 279010010898 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010010899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279010010900 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 279010010901 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 279010010902 Chlorite dismutase; Region: Chlor_dismutase; cl01280 279010010903 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279010010904 Cation transport protein; Region: TrkH; cl10514 279010010905 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 279010010906 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279010010907 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010010908 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 279010010909 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010010910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010010911 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 279010010912 Walker A/P-loop; other site 279010010913 ATP binding site [chemical binding]; other site 279010010914 Q-loop/lid; other site 279010010915 ABC transporter signature motif; other site 279010010916 Walker B; other site 279010010917 D-loop; other site 279010010918 H-loop/switch region; other site 279010010919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010010920 Histidine kinase; Region: HisKA_3; pfam07730 279010010921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 279010010922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010010923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010010924 active site 279010010925 phosphorylation site [posttranslational modification] 279010010926 intermolecular recognition site; other site 279010010927 dimerization interface [polypeptide binding]; other site 279010010928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010010929 DNA binding residues [nucleotide binding] 279010010930 dimerization interface [polypeptide binding]; other site 279010010931 Protein of unknown function (DUF423); Region: DUF423; cl01008 279010010932 Permease family; Region: Xan_ur_permease; pfam00860 279010010933 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 279010010934 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 279010010935 NAD(P) binding site [chemical binding]; other site 279010010936 catalytic residues [active] 279010010937 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 279010010938 ligand binding site [chemical binding]; other site 279010010939 active site 279010010940 UGI interface [polypeptide binding]; other site 279010010941 catalytic site [active] 279010010942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279010010943 active site 279010010944 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279010010945 dimer interface [polypeptide binding]; other site 279010010946 substrate binding site [chemical binding]; other site 279010010947 ATP binding site [chemical binding]; other site 279010010948 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 279010010949 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010010950 substrate binding [chemical binding]; other site 279010010951 active site 279010010952 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010010953 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 279010010954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010010955 active site turn [active] 279010010956 phosphorylation site [posttranslational modification] 279010010957 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010010958 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010010959 CAT RNA binding domain; Region: CAT_RBD; cl03904 279010010960 PRD domain; Region: PRD; cl15445 279010010961 PRD domain; Region: PRD; cl15445 279010010962 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 279010010963 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 279010010964 putative active site [active] 279010010965 catalytic triad [active] 279010010966 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 279010010967 PA/protease domain interface [polypeptide binding]; other site 279010010968 putative integrin binding motif; other site 279010010969 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 279010010970 FlgD Ig-like domain; Region: FlgD_ig; cl15790 279010010971 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279010010972 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 279010010973 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 279010010974 dimer interface [polypeptide binding]; other site 279010010975 FMN binding site [chemical binding]; other site 279010010976 NADPH bind site [chemical binding]; other site 279010010977 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279010010978 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279010010979 metal binding site [ion binding]; metal-binding site 279010010980 dimer interface [polypeptide binding]; other site 279010010981 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010010982 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 279010010983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 279010010984 Nucleoside recognition; Region: Gate; cl00486 279010010985 Clostripain family; Region: Peptidase_C11; cl04055 279010010986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010010987 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 279010010988 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010010989 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010010990 Walker A/P-loop; other site 279010010991 ATP binding site [chemical binding]; other site 279010010992 Q-loop/lid; other site 279010010993 ABC transporter signature motif; other site 279010010994 Walker B; other site 279010010995 D-loop; other site 279010010996 H-loop/switch region; other site 279010010997 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010010998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010010999 Walker A/P-loop; other site 279010011000 ATP binding site [chemical binding]; other site 279010011001 Q-loop/lid; other site 279010011002 ABC transporter signature motif; other site 279010011003 Walker B; other site 279010011004 D-loop; other site 279010011005 H-loop/switch region; other site 279010011006 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 279010011007 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 279010011008 Ligand Binding Site [chemical binding]; other site 279010011009 Molecular Tunnel; other site 279010011010 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 279010011011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011013 active site 279010011014 phosphorylation site [posttranslational modification] 279010011015 intermolecular recognition site; other site 279010011016 dimerization interface [polypeptide binding]; other site 279010011017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011018 DNA binding residues [nucleotide binding] 279010011019 dimerization interface [polypeptide binding]; other site 279010011020 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 279010011021 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 279010011022 Subunit I/III interface [polypeptide binding]; other site 279010011023 Subunit III/IV interface [polypeptide binding]; other site 279010011024 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 279010011025 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 279010011026 D-pathway; other site 279010011027 Putative ubiquinol binding site [chemical binding]; other site 279010011028 Low-spin heme (heme b) binding site [chemical binding]; other site 279010011029 Putative water exit pathway; other site 279010011030 Binuclear center (heme o3/CuB) [ion binding]; other site 279010011031 K-pathway; other site 279010011032 Putative proton exit pathway; other site 279010011033 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 279010011034 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 279010011035 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 279010011036 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010011037 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010011038 NAD binding site [chemical binding]; other site 279010011039 homodimer interface [polypeptide binding]; other site 279010011040 active site 279010011041 substrate binding site [chemical binding]; other site 279010011042 Anti-repressor SinI; Region: SinI; pfam08671 279010011043 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010011044 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 279010011045 Protein of unknown function, DUF485; Region: DUF485; cl01231 279010011046 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010011047 Sodium:solute symporter family; Region: SSF; cl00456 279010011048 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 279010011049 N- and C-terminal domain interface [polypeptide binding]; other site 279010011050 D-xylulose kinase; Region: XylB; TIGR01312 279010011051 active site 279010011052 catalytic site [active] 279010011053 metal binding site [ion binding]; metal-binding site 279010011054 xylulose binding site [chemical binding]; other site 279010011055 putative ATP binding site [chemical binding]; other site 279010011056 homodimer interface [polypeptide binding]; other site 279010011057 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 279010011058 Helix-turn-helix domains; Region: HTH; cl00088 279010011059 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010011060 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 279010011061 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279010011062 thiamine phosphate binding site [chemical binding]; other site 279010011063 active site 279010011064 pyrophosphate binding site [ion binding]; other site 279010011065 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 279010011066 substrate binding site [chemical binding]; other site 279010011067 multimerization interface [polypeptide binding]; other site 279010011068 ATP binding site [chemical binding]; other site 279010011069 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 279010011070 putative dimerization interface [polypeptide binding]; other site 279010011071 Helix-turn-helix domains; Region: HTH; cl00088 279010011072 LrgA family; Region: LrgA; cl00608 279010011073 LrgB-like family; Region: LrgB; cl00596 279010011074 Sodium:solute symporter family; Region: SSF; cl00456 279010011075 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 279010011076 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 279010011077 PUA domain; Region: PUA; cl00607 279010011078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 279010011079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010011080 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 279010011081 dimer interface [polypeptide binding]; other site 279010011082 substrate binding site [chemical binding]; other site 279010011083 metal binding site [ion binding]; metal-binding site 279010011084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011085 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 279010011086 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 279010011087 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 279010011088 Ligand binding site; other site 279010011089 metal-binding site 279010011090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010011091 Histidine kinase; Region: HisKA_3; pfam07730 279010011092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011093 ATP binding site [chemical binding]; other site 279010011094 Mg2+ binding site [ion binding]; other site 279010011095 G-X-G motif; other site 279010011096 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011098 active site 279010011099 phosphorylation site [posttranslational modification] 279010011100 intermolecular recognition site; other site 279010011101 dimerization interface [polypeptide binding]; other site 279010011102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011103 DNA binding residues [nucleotide binding] 279010011104 dimerization interface [polypeptide binding]; other site 279010011105 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 279010011106 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 279010011107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011108 D-galactonate transporter; Region: 2A0114; TIGR00893 279010011109 putative substrate translocation pore; other site 279010011110 galactonate dehydratase; Provisional; Region: PRK14017 279010011111 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 279010011112 putative active site pocket [active] 279010011113 putative metal binding site [ion binding]; other site 279010011114 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 279010011115 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 279010011116 active site 279010011117 intersubunit interface [polypeptide binding]; other site 279010011118 catalytic residue [active] 279010011119 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010011120 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010011121 substrate binding site [chemical binding]; other site 279010011122 ATP binding site [chemical binding]; other site 279010011123 Transcriptional regulator [Transcription]; Region: IclR; COG1414 279010011124 Helix-turn-helix domains; Region: HTH; cl00088 279010011125 Bacterial transcriptional regulator; Region: IclR; pfam01614 279010011126 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 279010011127 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 279010011128 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 279010011129 putative integrin binding motif; other site 279010011130 PA/protease domain interface [polypeptide binding]; other site 279010011131 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 279010011132 metal binding site [ion binding]; metal-binding site 279010011133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010011135 putative substrate translocation pore; other site 279010011136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011137 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279010011138 synthetase active site [active] 279010011139 NTP binding site [chemical binding]; other site 279010011140 metal binding site [ion binding]; metal-binding site 279010011141 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 279010011142 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 279010011143 AMP-binding enzyme; Region: AMP-binding; cl15778 279010011144 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 279010011145 Phosphopantetheine attachment site; Region: PP-binding; cl09936 279010011146 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 279010011147 DltD N-terminal region; Region: DltD_N; pfam04915 279010011148 DltD central region; Region: DltD_M; pfam04918 279010011149 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 279010011150 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 279010011151 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 279010011152 homodimer interface [polypeptide binding]; other site 279010011153 substrate-cofactor binding pocket; other site 279010011154 catalytic residue [active] 279010011155 H+ Antiporter protein; Region: 2A0121; TIGR00900 279010011156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011157 putative substrate translocation pore; other site 279010011158 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 279010011159 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 279010011160 NAD binding site [chemical binding]; other site 279010011161 sugar binding site [chemical binding]; other site 279010011162 divalent metal binding site [ion binding]; other site 279010011163 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010011164 dimer interface [polypeptide binding]; other site 279010011165 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279010011166 methionine cluster; other site 279010011167 active site 279010011168 phosphorylation site [posttranslational modification] 279010011169 metal binding site [ion binding]; metal-binding site 279010011170 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010011171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010011172 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279010011173 active site 279010011174 P-loop; other site 279010011175 phosphorylation site [posttranslational modification] 279010011176 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279010011177 Helix-turn-helix domains; Region: HTH; cl00088 279010011178 Helix-turn-helix domains; Region: HTH; cl00088 279010011179 PRD domain; Region: PRD; cl15445 279010011180 PRD domain; Region: PRD; cl15445 279010011181 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279010011182 P-loop; other site 279010011183 active site 279010011184 phosphorylation site [posttranslational modification] 279010011185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279010011186 active site 279010011187 phosphorylation site [posttranslational modification] 279010011188 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 279010011189 active site 279010011190 DNA binding site [nucleotide binding] 279010011191 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010011192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010011193 DNA-binding site [nucleotide binding]; DNA binding site 279010011194 FCD domain; Region: FCD; cl11656 279010011195 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 279010011196 dimer interface [polypeptide binding]; other site 279010011197 Citrate synthase; Region: Citrate_synt; pfam00285 279010011198 active site 279010011199 coenzyme A binding site [chemical binding]; other site 279010011200 citrylCoA binding site [chemical binding]; other site 279010011201 oxalacetate/citrate binding site [chemical binding]; other site 279010011202 catalytic triad [active] 279010011203 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 279010011204 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 279010011205 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010011206 tetramer interface [polypeptide binding]; other site 279010011207 active site 279010011208 Mg2+/Mn2+ binding site [ion binding]; other site 279010011209 Chromate transporter; Region: Chromate_transp; pfam02417 279010011210 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 279010011211 Chromate transporter; Region: Chromate_transp; pfam02417 279010011212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279010011213 Helix-turn-helix domains; Region: HTH; cl00088 279010011214 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279010011215 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010011216 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 279010011217 Walker A/P-loop; other site 279010011218 ATP binding site [chemical binding]; other site 279010011219 Q-loop/lid; other site 279010011220 ABC transporter signature motif; other site 279010011221 Walker B; other site 279010011222 D-loop; other site 279010011223 H-loop/switch region; other site 279010011224 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 279010011225 active site 279010011226 catalytic triad [active] 279010011227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011228 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 279010011229 putative substrate translocation pore; other site 279010011230 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010011231 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011233 Walker A/P-loop; other site 279010011234 ATP binding site [chemical binding]; other site 279010011235 Q-loop/lid; other site 279010011236 ABC transporter signature motif; other site 279010011237 Walker B; other site 279010011238 D-loop; other site 279010011239 H-loop/switch region; other site 279010011240 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 279010011241 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279010011242 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 279010011243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010011244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010011245 DNA binding residues [nucleotide binding] 279010011246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279010011248 putative substrate translocation pore; other site 279010011249 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 279010011250 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 279010011251 tetramer interface [polypeptide binding]; other site 279010011252 heme binding pocket [chemical binding]; other site 279010011253 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 279010011254 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 279010011255 tetramer interface [polypeptide binding]; other site 279010011256 heme binding pocket [chemical binding]; other site 279010011257 NADPH binding site [chemical binding]; other site 279010011258 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279010011259 metal binding site 2 [ion binding]; metal-binding site 279010011260 putative DNA binding helix; other site 279010011261 metal binding site 1 [ion binding]; metal-binding site 279010011262 dimer interface [polypeptide binding]; other site 279010011263 structural Zn2+ binding site [ion binding]; other site 279010011264 ferrochelatase; Provisional; Region: PRK12435 279010011265 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 279010011266 C-terminal domain interface [polypeptide binding]; other site 279010011267 active site 279010011268 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 279010011269 active site 279010011270 N-terminal domain interface [polypeptide binding]; other site 279010011271 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010011272 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011274 Walker A/P-loop; other site 279010011275 ATP binding site [chemical binding]; other site 279010011276 Q-loop/lid; other site 279010011277 ABC transporter signature motif; other site 279010011278 Walker B; other site 279010011279 D-loop; other site 279010011280 H-loop/switch region; other site 279010011281 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010011282 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010011283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279010011284 Walker A/P-loop; other site 279010011285 ATP binding site [chemical binding]; other site 279010011286 Q-loop/lid; other site 279010011287 ABC transporter signature motif; other site 279010011288 Walker B; other site 279010011289 D-loop; other site 279010011290 H-loop/switch region; other site 279010011291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010011292 non-specific DNA binding site [nucleotide binding]; other site 279010011293 salt bridge; other site 279010011294 sequence-specific DNA binding site [nucleotide binding]; other site 279010011295 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 279010011296 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 279010011297 active site 279010011298 catalytic residues [active] 279010011299 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 279010011300 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39F; cd02425 279010011301 putative active site [active] 279010011302 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010011303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011304 Walker A/P-loop; other site 279010011305 ATP binding site [chemical binding]; other site 279010011306 Q-loop/lid; other site 279010011307 ABC transporter signature motif; other site 279010011308 Walker B; other site 279010011309 D-loop; other site 279010011310 H-loop/switch region; other site 279010011311 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 279010011312 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 279010011313 active site 279010011314 zinc binding site [ion binding]; other site 279010011315 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 279010011316 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 279010011317 active site 279010011318 zinc binding site [ion binding]; other site 279010011319 Pectate lyase; Region: Pec_lyase_C; cl01593 279010011320 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 279010011321 putative substrate binding site [chemical binding]; other site 279010011322 putative ATP binding site [chemical binding]; other site 279010011323 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 279010011324 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010011325 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 279010011326 Walker A/P-loop; other site 279010011327 ATP binding site [chemical binding]; other site 279010011328 Q-loop/lid; other site 279010011329 ABC transporter signature motif; other site 279010011330 Walker B; other site 279010011331 D-loop; other site 279010011332 H-loop/switch region; other site 279010011333 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 279010011334 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 279010011335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011336 Walker A/P-loop; other site 279010011337 ATP binding site [chemical binding]; other site 279010011338 Q-loop/lid; other site 279010011339 ABC transporter signature motif; other site 279010011340 Walker B; other site 279010011341 D-loop; other site 279010011342 H-loop/switch region; other site 279010011343 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 279010011344 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 279010011345 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 279010011346 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 279010011347 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 279010011348 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 279010011349 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279010011350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011351 NAD(P) binding pocket [chemical binding]; other site 279010011352 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 279010011353 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 279010011354 Aspartase; Region: Aspartase; cd01357 279010011355 active sites [active] 279010011356 tetramer interface [polypeptide binding]; other site 279010011357 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 279010011358 active site 279010011359 homodimer interface [polypeptide binding]; other site 279010011360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279010011361 non-specific DNA binding site [nucleotide binding]; other site 279010011362 salt bridge; other site 279010011363 sequence-specific DNA binding site [nucleotide binding]; other site 279010011364 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 279010011365 Response regulator receiver domain; Region: Response_reg; pfam00072 279010011366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011367 active site 279010011368 phosphorylation site [posttranslational modification] 279010011369 intermolecular recognition site; other site 279010011370 dimerization interface [polypeptide binding]; other site 279010011371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010011372 DNA binding site [nucleotide binding] 279010011373 adaptive-response sensory kinase; Validated; Region: PRK09303 279010011374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 279010011375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011376 ATP binding site [chemical binding]; other site 279010011377 Mg2+ binding site [ion binding]; other site 279010011378 G-X-G motif; other site 279010011379 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010011380 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010011381 Walker A/P-loop; other site 279010011382 ATP binding site [chemical binding]; other site 279010011383 Q-loop/lid; other site 279010011384 ABC transporter signature motif; other site 279010011385 Walker B; other site 279010011386 D-loop; other site 279010011387 H-loop/switch region; other site 279010011388 FtsX-like permease family; Region: FtsX; cl15850 279010011389 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 279010011390 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 279010011391 putative active site [active] 279010011392 putative metal binding site [ion binding]; other site 279010011393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279010011394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010011395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010011396 homodimer interface [polypeptide binding]; other site 279010011397 catalytic residue [active] 279010011398 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 279010011399 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 279010011400 DXD motif; other site 279010011401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 279010011402 PilZ domain; Region: PilZ; cl01260 279010011403 PilZ domain; Region: PilZ; cl01260 279010011404 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 279010011405 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279010011406 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 279010011407 active site 279010011408 catalytic site [active] 279010011409 Excalibur calcium-binding domain; Region: Excalibur; cl05460 279010011410 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279010011411 Sulfatase; Region: Sulfatase; cl10460 279010011412 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010011413 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279010011414 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 279010011415 Arginine repressor [Transcription]; Region: ArgR; COG1438 279010011416 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279010011417 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279010011418 Amidinotransferase; Region: Amidinotransf; cl12043 279010011419 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 279010011420 ornithine carbamoyltransferase; Validated; Region: PRK02102 279010011421 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279010011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011423 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 279010011424 carbamate kinase; Reviewed; Region: PRK12686 279010011425 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 279010011426 putative substrate binding site [chemical binding]; other site 279010011427 nucleotide binding site [chemical binding]; other site 279010011428 nucleotide binding site [chemical binding]; other site 279010011429 homodimer interface [polypeptide binding]; other site 279010011430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 279010011431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279010011432 ligand binding site [chemical binding]; other site 279010011433 flexible hinge region; other site 279010011434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279010011435 putative switch regulator; other site 279010011436 non-specific DNA interactions [nucleotide binding]; other site 279010011437 DNA binding site [nucleotide binding] 279010011438 sequence specific DNA binding site [nucleotide binding]; other site 279010011439 putative cAMP binding site [chemical binding]; other site 279010011440 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010011441 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010011442 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279010011443 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 279010011444 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 279010011445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010011446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010011447 DNA binding residues [nucleotide binding] 279010011448 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 279010011449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279010011450 FeS/SAM binding site; other site 279010011451 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 279010011452 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 279010011453 hypothetical protein; Provisional; Region: PHA02943 279010011454 Ycf46; Provisional; Region: ycf46; CHL00195 279010011455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279010011456 Walker A motif; other site 279010011457 ATP binding site [chemical binding]; other site 279010011458 Walker B motif; other site 279010011459 arginine finger; other site 279010011460 peptidase T; Region: peptidase-T; TIGR01882 279010011461 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 279010011462 metal binding site [ion binding]; metal-binding site 279010011463 dimer interface [polypeptide binding]; other site 279010011464 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 279010011465 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279010011466 substrate binding [chemical binding]; other site 279010011467 active site 279010011468 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279010011469 galactoside permease; Reviewed; Region: lacY; PRK09528 279010011470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011471 putative substrate translocation pore; other site 279010011472 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 279010011473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010011474 dimer interface [polypeptide binding]; other site 279010011475 conserved gate region; other site 279010011476 putative PBP binding loops; other site 279010011477 ABC-ATPase subunit interface; other site 279010011478 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 279010011479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 279010011480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010011481 putative PBP binding loops; other site 279010011482 dimer interface [polypeptide binding]; other site 279010011483 ABC-ATPase subunit interface; other site 279010011484 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 279010011485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010011486 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010011487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010011488 DNA binding site [nucleotide binding] 279010011489 domain linker motif; other site 279010011490 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 279010011491 dimerization interface [polypeptide binding]; other site 279010011492 ligand binding site [chemical binding]; other site 279010011493 sodium binding site [ion binding]; other site 279010011494 UTRA domain; Region: UTRA; cl01230 279010011495 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 279010011496 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 279010011497 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279010011498 substrate binding site [chemical binding]; other site 279010011499 THF binding site; other site 279010011500 zinc-binding site [ion binding]; other site 279010011501 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 279010011502 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 279010011503 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 279010011504 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279010011505 Ligand binding site; other site 279010011506 Putative Catalytic site; other site 279010011507 DXD motif; other site 279010011508 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010011509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011510 NAD(P) binding site [chemical binding]; other site 279010011511 active site 279010011512 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279010011513 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 279010011514 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 279010011515 nucleoside transporter; Region: nupC; TIGR00804 279010011516 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010011517 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010011518 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 279010011519 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 279010011520 domain interactions; other site 279010011521 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 279010011522 heme binding pocket [chemical binding]; other site 279010011523 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 279010011524 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010011525 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010011526 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010011527 active site turn [active] 279010011528 phosphorylation site [posttranslational modification] 279010011529 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010011530 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 279010011531 HPr interaction site; other site 279010011532 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010011533 active site 279010011534 phosphorylation site [posttranslational modification] 279010011535 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279010011536 CAT RNA binding domain; Region: CAT_RBD; cl03904 279010011537 PRD domain; Region: PRD; cl15445 279010011538 PRD domain; Region: PRD; cl15445 279010011539 Cobalt transport protein; Region: CbiQ; cl00463 279010011540 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 279010011541 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 279010011542 Walker A/P-loop; other site 279010011543 ATP binding site [chemical binding]; other site 279010011544 Q-loop/lid; other site 279010011545 ABC transporter signature motif; other site 279010011546 Walker B; other site 279010011547 D-loop; other site 279010011548 H-loop/switch region; other site 279010011549 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 279010011550 Walker A/P-loop; other site 279010011551 ATP binding site [chemical binding]; other site 279010011552 Q-loop/lid; other site 279010011553 ABC transporter signature motif; other site 279010011554 Walker B; other site 279010011555 D-loop; other site 279010011556 H-loop/switch region; other site 279010011557 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 279010011558 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 279010011559 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 279010011560 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 279010011561 tetramer interface [polypeptide binding]; other site 279010011562 active site 279010011563 Mg2+/Mn2+ binding site [ion binding]; other site 279010011564 malate synthase A; Region: malate_syn_A; TIGR01344 279010011565 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 279010011566 active site 279010011567 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 279010011568 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 279010011569 FtsX-like permease family; Region: FtsX; cl15850 279010011570 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010011571 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010011572 Walker A/P-loop; other site 279010011573 ATP binding site [chemical binding]; other site 279010011574 Q-loop/lid; other site 279010011575 ABC transporter signature motif; other site 279010011576 Walker B; other site 279010011577 D-loop; other site 279010011578 H-loop/switch region; other site 279010011579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279010011580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011581 ATP binding site [chemical binding]; other site 279010011582 Mg2+ binding site [ion binding]; other site 279010011583 G-X-G motif; other site 279010011584 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010011585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011586 active site 279010011587 phosphorylation site [posttranslational modification] 279010011588 intermolecular recognition site; other site 279010011589 dimerization interface [polypeptide binding]; other site 279010011590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010011591 DNA binding site [nucleotide binding] 279010011592 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 279010011593 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 279010011594 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010011595 active site turn [active] 279010011596 phosphorylation site [posttranslational modification] 279010011597 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010011598 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 279010011599 HPr interaction site; other site 279010011600 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279010011601 active site 279010011602 phosphorylation site [posttranslational modification] 279010011603 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 279010011604 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 279010011605 active site 279010011606 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 279010011607 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 279010011608 substrate binding site [chemical binding]; other site 279010011609 active site 279010011610 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 279010011611 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279010011612 ATP binding site [chemical binding]; other site 279010011613 Mg++ binding site [ion binding]; other site 279010011614 motif III; other site 279010011615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279010011616 nucleotide binding region [chemical binding]; other site 279010011617 ATP-binding site [chemical binding]; other site 279010011618 DbpA RNA binding domain; Region: DbpA; pfam03880 279010011619 LXG domain of WXG superfamily; Region: LXG; pfam04740 279010011620 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 279010011621 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279010011622 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279010011623 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 279010011624 nucleoside transporter; Region: nupC; TIGR00804 279010011625 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279010011626 Nucleoside recognition; Region: Gate; cl00486 279010011627 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279010011628 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 279010011629 intersubunit interface [polypeptide binding]; other site 279010011630 active site 279010011631 catalytic residue [active] 279010011632 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279010011633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 279010011634 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279010011635 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 279010011636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279010011637 metal binding site [ion binding]; metal-binding site 279010011638 active site 279010011639 I-site; other site 279010011640 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 279010011641 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 279010011642 NodB motif; other site 279010011643 putative active site [active] 279010011644 putative catalytic site [active] 279010011645 putative Zn binding site [ion binding]; other site 279010011646 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 279010011647 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 279010011648 DXD motif; other site 279010011649 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 279010011650 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 279010011651 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 279010011652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279010011653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279010011654 homodimer interface [polypeptide binding]; other site 279010011655 catalytic residue [active] 279010011656 Prephenate dehydratase; Region: PDT; pfam00800 279010011657 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 279010011658 ATP-grasp domain; Region: ATP-grasp_4; cl03087 279010011659 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 279010011660 EamA-like transporter family; Region: EamA; cl01037 279010011661 hypothetical protein; Provisional; Region: PRK08185 279010011662 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279010011663 intersubunit interface [polypeptide binding]; other site 279010011664 active site 279010011665 zinc binding site [ion binding]; other site 279010011666 Na+ binding site [ion binding]; other site 279010011667 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010011668 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011669 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010011670 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 279010011671 DNA interaction; other site 279010011672 Metal-binding active site; metal-binding site 279010011673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 279010011674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011675 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 279010011676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011677 putative substrate translocation pore; other site 279010011678 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 279010011679 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 279010011680 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279010011681 PYR/PP interface [polypeptide binding]; other site 279010011682 dimer interface [polypeptide binding]; other site 279010011683 TPP binding site [chemical binding]; other site 279010011684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 279010011685 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 279010011686 TPP-binding site; other site 279010011687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279010011688 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279010011689 substrate binding site [chemical binding]; other site 279010011690 ATP binding site [chemical binding]; other site 279010011691 KduI/IolB family; Region: KduI; cl01508 279010011692 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 279010011693 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279010011694 tetrameric interface [polypeptide binding]; other site 279010011695 NAD binding site [chemical binding]; other site 279010011696 catalytic residues [active] 279010011697 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279010011698 Helix-turn-helix domains; Region: HTH; cl00088 279010011699 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279010011700 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 279010011701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279010011702 active site 279010011703 catalytic tetrad [active] 279010011704 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279010011705 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 279010011706 active site 279010011707 catalytic site [active] 279010011708 metal binding site [ion binding]; metal-binding site 279010011709 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 279010011710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011711 putative substrate translocation pore; other site 279010011712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011713 heat shock protein 90; Provisional; Region: PRK05218 279010011714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 279010011715 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279010011716 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010011717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011718 ABC transporter signature motif; other site 279010011719 Walker B; other site 279010011720 D-loop; other site 279010011721 H-loop/switch region; other site 279010011722 ABC transporter; Region: ABC_tran_2; pfam12848 279010011723 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 279010011724 sugar phosphate phosphatase; Provisional; Region: PRK10513 279010011725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010011726 active site 279010011727 motif I; other site 279010011728 motif II; other site 279010011729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279010011730 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 279010011731 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 279010011732 active site 279010011733 metal binding site [ion binding]; metal-binding site 279010011734 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 279010011735 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 279010011736 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 279010011737 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 279010011738 putative ligand binding residues [chemical binding]; other site 279010011739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279010011740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 279010011741 active site 279010011742 metal binding site [ion binding]; metal-binding site 279010011743 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 279010011744 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 279010011745 G1 box; other site 279010011746 GTP/Mg2+ binding site [chemical binding]; other site 279010011747 Switch I region; other site 279010011748 G2 box; other site 279010011749 G3 box; other site 279010011750 Switch II region; other site 279010011751 G4 box; other site 279010011752 G5 box; other site 279010011753 Nucleoside recognition; Region: Gate; cl00486 279010011754 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 279010011755 Nucleoside recognition; Region: Gate; cl00486 279010011756 FeoA domain; Region: FeoA; cl00838 279010011757 OpgC protein; Region: OpgC_C; cl00792 279010011758 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279010011759 FtsX-like permease family; Region: FtsX; cl15850 279010011760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279010011761 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 279010011762 Walker A/P-loop; other site 279010011763 ATP binding site [chemical binding]; other site 279010011764 Q-loop/lid; other site 279010011765 ABC transporter signature motif; other site 279010011766 Walker B; other site 279010011767 D-loop; other site 279010011768 H-loop/switch region; other site 279010011769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 279010011770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011771 ATP binding site [chemical binding]; other site 279010011772 Mg2+ binding site [ion binding]; other site 279010011773 G-X-G motif; other site 279010011774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010011775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011776 active site 279010011777 phosphorylation site [posttranslational modification] 279010011778 intermolecular recognition site; other site 279010011779 dimerization interface [polypeptide binding]; other site 279010011780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010011781 DNA binding site [nucleotide binding] 279010011782 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 279010011783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 279010011784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 279010011785 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 279010011786 dimer interface [polypeptide binding]; other site 279010011787 putative CheW interface [polypeptide binding]; other site 279010011788 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279010011789 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 279010011790 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 279010011791 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 279010011792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011793 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 279010011794 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 279010011795 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 279010011796 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 279010011797 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 279010011798 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 279010011799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010011800 dimer interface [polypeptide binding]; other site 279010011801 conserved gate region; other site 279010011802 putative PBP binding loops; other site 279010011803 ABC-ATPase subunit interface; other site 279010011804 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 279010011805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279010011806 dimer interface [polypeptide binding]; other site 279010011807 conserved gate region; other site 279010011808 ABC-ATPase subunit interface; other site 279010011809 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 279010011810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279010011811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279010011812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279010011813 DNA binding site [nucleotide binding] 279010011814 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 279010011815 putative dimerization interface [polypeptide binding]; other site 279010011816 putative ligand binding site [chemical binding]; other site 279010011817 galactokinase; Provisional; Region: PRK05322 279010011818 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 279010011819 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279010011820 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279010011821 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 279010011822 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 279010011823 NAD binding site [chemical binding]; other site 279010011824 homodimer interface [polypeptide binding]; other site 279010011825 active site 279010011826 substrate binding site [chemical binding]; other site 279010011827 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 279010011828 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 279010011829 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 279010011830 Helix-turn-helix domains; Region: HTH; cl00088 279010011831 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279010011832 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 279010011833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279010011834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010011835 DNA-binding site [nucleotide binding]; DNA binding site 279010011836 FCD domain; Region: FCD; cl11656 279010011837 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 279010011838 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 279010011839 N- and C-terminal domain interface [polypeptide binding]; other site 279010011840 putative active site [active] 279010011841 catalytic site [active] 279010011842 metal binding site [ion binding]; metal-binding site 279010011843 carbohydrate binding site [chemical binding]; other site 279010011844 ATP binding site [chemical binding]; other site 279010011845 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 279010011846 gluconate transporter; Region: gntP; TIGR00791 279010011847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011848 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 279010011849 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 279010011850 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 279010011851 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 279010011852 putative catalytic cysteine [active] 279010011853 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 279010011854 putative active site [active] 279010011855 metal binding site [ion binding]; metal-binding site 279010011856 peroxiredoxin; Region: AhpC; TIGR03137 279010011857 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 279010011858 dimer interface [polypeptide binding]; other site 279010011859 decamer (pentamer of dimers) interface [polypeptide binding]; other site 279010011860 catalytic triad [active] 279010011861 peroxidatic and resolving cysteines [active] 279010011862 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 279010011863 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 279010011864 catalytic residue [active] 279010011865 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 279010011866 catalytic residues [active] 279010011867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279010011868 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 279010011869 GIY-YIG motif/motif A; other site 279010011870 active site 279010011871 catalytic site [active] 279010011872 metal binding site [ion binding]; metal-binding site 279010011873 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 279010011874 Uncharacterized conserved protein [Function unknown]; Region: COG3410 279010011875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279010011876 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 279010011877 Walker A/P-loop; other site 279010011878 ATP binding site [chemical binding]; other site 279010011879 Q-loop/lid; other site 279010011880 ABC transporter signature motif; other site 279010011881 Walker B; other site 279010011882 D-loop; other site 279010011883 H-loop/switch region; other site 279010011884 ABC-2 type transporter; Region: ABC2_membrane; cl11417 279010011885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279010011886 Histidine kinase; Region: HisKA_3; pfam07730 279010011887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279010011888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011889 active site 279010011890 phosphorylation site [posttranslational modification] 279010011891 intermolecular recognition site; other site 279010011892 dimerization interface [polypeptide binding]; other site 279010011893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279010011894 DNA binding residues [nucleotide binding] 279010011895 dimerization interface [polypeptide binding]; other site 279010011896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010011897 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 279010011898 Walker A/P-loop; other site 279010011899 ATP binding site [chemical binding]; other site 279010011900 Q-loop/lid; other site 279010011901 ABC transporter signature motif; other site 279010011902 Walker B; other site 279010011903 D-loop; other site 279010011904 H-loop/switch region; other site 279010011905 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 279010011906 DNA binding site [nucleotide binding] 279010011907 Int/Topo IB signature motif; other site 279010011908 active site 279010011909 catalytic residues [active] 279010011910 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 279010011911 active site 279010011912 NTP binding site [chemical binding]; other site 279010011913 metal binding triad [ion binding]; metal-binding site 279010011914 Protein of unknown function DUF45; Region: DUF45; cl00636 279010011915 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 279010011916 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 279010011917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279010011918 ATP binding site [chemical binding]; other site 279010011919 putative Mg++ binding site [ion binding]; other site 279010011920 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 279010011921 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010011922 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279010011923 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010011924 Virulence protein [General function prediction only]; Region: COG3943 279010011925 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 279010011926 HsdM N-terminal domain; Region: HsdM_N; pfam12161 279010011927 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 279010011928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010011929 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279010011930 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010011931 catalytic nucleophile [active] 279010011932 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 279010011933 Recombinase; Region: Recombinase; pfam07508 279010011934 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279010011935 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279010011936 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279010011937 catalytic residues [active] 279010011938 catalytic nucleophile [active] 279010011939 Recombinase; Region: Recombinase; pfam07508 279010011940 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279010011941 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 279010011942 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 279010011943 YyzF-like protein; Region: YyzF; cl15733 279010011944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279010011945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279010011946 Coenzyme A binding pocket [chemical binding]; other site 279010011947 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 279010011948 Uncharacterized conserved protein [Function unknown]; Region: COG1912 279010011949 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 279010011950 serine endoprotease; Provisional; Region: PRK10898 279010011951 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 279010011952 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279010011953 protein binding site [polypeptide binding]; other site 279010011954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279010011955 YycH protein; Region: YycI; cl02015 279010011956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 279010011957 YycH protein; Region: YycH; pfam07435 279010011958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279010011959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279010011960 dimerization interface [polypeptide binding]; other site 279010011961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279010011962 putative active site [active] 279010011963 heme pocket [chemical binding]; other site 279010011964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279010011965 dimer interface [polypeptide binding]; other site 279010011966 phosphorylation site [posttranslational modification] 279010011967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279010011968 ATP binding site [chemical binding]; other site 279010011969 Mg2+ binding site [ion binding]; other site 279010011970 G-X-G motif; other site 279010011971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279010011972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279010011973 active site 279010011974 phosphorylation site [posttranslational modification] 279010011975 intermolecular recognition site; other site 279010011976 dimerization interface [polypeptide binding]; other site 279010011977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279010011978 DNA binding site [nucleotide binding] 279010011979 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 279010011980 nudix motif; other site 279010011981 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 279010011982 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 279010011983 GDP-binding site [chemical binding]; other site 279010011984 ACT binding site; other site 279010011985 IMP binding site; other site 279010011986 replicative DNA helicase; Provisional; Region: PRK05748 279010011987 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 279010011988 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 279010011989 Walker A motif; other site 279010011990 ATP binding site [chemical binding]; other site 279010011991 Walker B motif; other site 279010011992 DNA binding loops [nucleotide binding] 279010011993 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 279010011994 YycC-like protein; Region: YycC; pfam14174 279010011995 cyanate transporter; Region: CynX; TIGR00896 279010011996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010011997 putative substrate translocation pore; other site 279010011998 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 279010011999 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 279010012000 active site 279010012001 dimer interface [polypeptide binding]; other site 279010012002 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 279010012003 active site 279010012004 trimer interface [polypeptide binding]; other site 279010012005 allosteric site; other site 279010012006 active site lid [active] 279010012007 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279010012008 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279010012009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279010012010 DNA-binding site [nucleotide binding]; DNA binding site 279010012011 UTRA domain; Region: UTRA; cl01230 279010012012 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 279010012013 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 279010012014 putative active site [active] 279010012015 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 279010012016 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 279010012017 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279010012018 active site turn [active] 279010012019 phosphorylation site [posttranslational modification] 279010012020 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 279010012021 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 279010012022 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 279010012023 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 279010012024 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 279010012025 DHH family; Region: DHH; pfam01368 279010012026 DHHA1 domain; Region: DHHA1; pfam02272 279010012027 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 279010012028 Coat F domain; Region: Coat_F; cl15836 279010012029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279010012030 Ligand Binding Site [chemical binding]; other site 279010012031 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 279010012032 Sulfate transporter family; Region: Sulfate_transp; cl15842 279010012033 Sulfate transporter family; Region: Sulfate_transp; cl15842 279010012034 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 279010012035 D-galactonate transporter; Region: 2A0114; TIGR00893 279010012036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279010012037 putative substrate translocation pore; other site 279010012038 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 279010012039 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279010012040 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279010012041 dimer interface [polypeptide binding]; other site 279010012042 ssDNA binding site [nucleotide binding]; other site 279010012043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279010012044 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 279010012045 GTP-binding protein YchF; Reviewed; Region: PRK09601 279010012046 YchF GTPase; Region: YchF; cd01900 279010012047 G1 box; other site 279010012048 GTP/Mg2+ binding site [chemical binding]; other site 279010012049 Switch I region; other site 279010012050 G2 box; other site 279010012051 Switch II region; other site 279010012052 G3 box; other site 279010012053 G4 box; other site 279010012054 G5 box; other site 279010012055 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 279010012056 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 279010012057 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279010012058 Spore germination protein; Region: Spore_permease; cl15802 279010012059 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 279010012060 ParB-like partition proteins; Region: parB_part; TIGR00180 279010012061 ParB-like nuclease domain; Region: ParBc; cl02129 279010012062 KorB domain; Region: KorB; pfam08535 279010012063 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 279010012064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 279010012065 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 279010012066 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 279010012067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279010012068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279010012069 DNA binding residues [nucleotide binding] 279010012070 ParB-like partition proteins; Region: parB_part; TIGR00180 279010012071 ParB-like nuclease domain; Region: ParBc; cl02129 279010012072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279010012073 S-adenosylmethionine binding site [chemical binding]; other site 279010012074 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 279010012075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279010012076 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 279010012077 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 279010012078 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 279010012079 trmE is a tRNA modification GTPase; Region: trmE; cd04164 279010012080 G1 box; other site 279010012081 GTP/Mg2+ binding site [chemical binding]; other site 279010012082 Switch I region; other site 279010012083 G2 box; other site 279010012084 Switch II region; other site 279010012085 G3 box; other site 279010012086 G4 box; other site 279010012087 G5 box; other site 279010012088 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 279010012089 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 279010012090 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 279010012091 G-X-X-G motif; other site 279010012092 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 279010012093 RxxxH motif; other site 279010012094 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 279010012095 Ribonuclease P; Region: Ribonuclease_P; cl00457 279010012096 Ribosomal protein L34; Region: Ribosomal_L34; cl00370