-- dump date 20120504_134155 -- class Genbank::misc_feature -- table misc_feature_note -- id note 545693000001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693000002 Bacterial Ig-like domain; Region: Big_5; cl01012 545693000003 Copper resistance protein D; Region: CopD; cl00563 545693000004 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 545693000005 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 545693000006 Predicted permease; Region: DUF318; pfam03773 545693000007 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 545693000008 Predicted permeases [General function prediction only]; Region: COG0701 545693000009 Predicted permease; Region: DUF318; pfam03773 545693000010 Transposase, Mutator family; Region: Transposase_mut; pfam00872 545693000011 MULE transposase domain; Region: MULE; pfam10551 545693000012 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693000013 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693000014 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693000016 NAD(P) binding site [chemical binding]; other site 545693000017 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 545693000018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693000019 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693000021 Replication-relaxation; Region: Replic_Relax; pfam13814 545693000022 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 545693000023 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000024 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 545693000025 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 545693000026 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693000027 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693000028 putative active site [active] 545693000029 putative NTP binding site [chemical binding]; other site 545693000030 putative nucleic acid binding site [nucleotide binding]; other site 545693000031 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 545693000032 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 545693000033 IDEAL domain; Region: IDEAL; cl07452 545693000034 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 545693000035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693000036 active site 545693000037 DNA binding site [nucleotide binding] 545693000038 Int/Topo IB signature motif; other site 545693000039 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693000040 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693000041 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693000042 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 545693000043 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 545693000044 nucleotide binding site [chemical binding]; other site 545693000045 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 545693000046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000047 non-specific DNA binding site [nucleotide binding]; other site 545693000048 salt bridge; other site 545693000049 sequence-specific DNA binding site [nucleotide binding]; other site 545693000050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693000051 Helix-turn-helix domains; Region: HTH; cl00088 545693000052 DNA binding residues [nucleotide binding] 545693000053 dimerization interface [polypeptide binding]; other site 545693000054 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 545693000055 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 545693000056 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693000057 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693000058 argininosuccinate lyase; Provisional; Region: PRK02186 545693000059 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693000060 YvrJ protein family; Region: YvrJ; pfam12841 545693000061 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693000062 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 545693000063 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 545693000064 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 545693000065 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 545693000066 catalytic residues [active] 545693000067 catalytic nucleophile [active] 545693000068 Presynaptic Site I dimer interface [polypeptide binding]; other site 545693000069 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 545693000070 Synaptic Flat tetramer interface [polypeptide binding]; other site 545693000071 Synaptic Site I dimer interface [polypeptide binding]; other site 545693000072 DNA binding site [nucleotide binding] 545693000073 Recombinase; Region: Recombinase; pfam07508 545693000074 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 545693000075 MobA/MobL family; Region: MobA_MobL; pfam03389 545693000076 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 545693000077 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 545693000078 DnaA N-terminal domain; Region: DnaA_N; pfam11638 545693000079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000080 Walker A motif; other site 545693000081 ATP binding site [chemical binding]; other site 545693000082 Walker B motif; other site 545693000083 arginine finger; other site 545693000084 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 545693000085 DnaA box-binding interface [nucleotide binding]; other site 545693000086 DNA polymerase III subunit beta; Validated; Region: PRK05643 545693000087 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 545693000088 putative DNA binding surface [nucleotide binding]; other site 545693000089 dimer interface [polypeptide binding]; other site 545693000090 beta-clamp/clamp loader binding surface; other site 545693000091 beta-clamp/translesion DNA polymerase binding surface; other site 545693000092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 545693000093 recombination protein F; Reviewed; Region: recF; PRK00064 545693000094 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 545693000095 Walker A/P-loop; other site 545693000096 ATP binding site [chemical binding]; other site 545693000097 Q-loop/lid; other site 545693000098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693000099 ABC transporter signature motif; other site 545693000100 Walker B; other site 545693000101 D-loop; other site 545693000102 H-loop/switch region; other site 545693000103 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 545693000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000105 Mg2+ binding site [ion binding]; other site 545693000106 G-X-G motif; other site 545693000107 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 545693000108 anchoring element; other site 545693000109 dimer interface [polypeptide binding]; other site 545693000110 ATP binding site [chemical binding]; other site 545693000111 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 545693000112 active site 545693000113 putative metal-binding site [ion binding]; other site 545693000114 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 545693000115 DNA gyrase subunit A; Validated; Region: PRK05560 545693000116 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 545693000117 CAP-like domain; other site 545693000118 active site 545693000119 primary dimer interface [polypeptide binding]; other site 545693000120 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000125 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693000126 YaaC-like Protein; Region: YaaC; pfam14175 545693000127 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 545693000128 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 545693000129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 545693000130 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 545693000131 active site 545693000132 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 545693000133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693000134 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 545693000135 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 545693000136 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 545693000137 active site 545693000138 multimer interface [polypeptide binding]; other site 545693000139 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 545693000140 predicted active site [active] 545693000141 catalytic triad [active] 545693000142 seryl-tRNA synthetase; Provisional; Region: PRK05431 545693000143 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 545693000144 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 545693000145 dimer interface [polypeptide binding]; other site 545693000146 active site 545693000147 motif 1; other site 545693000148 motif 2; other site 545693000149 motif 3; other site 545693000150 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 545693000151 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 545693000152 Substrate-binding site [chemical binding]; other site 545693000153 Substrate specificity [chemical binding]; other site 545693000154 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 545693000155 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 545693000156 Substrate-binding site [chemical binding]; other site 545693000157 Substrate specificity [chemical binding]; other site 545693000158 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693000159 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693000160 putative peptidoglycan binding site; other site 545693000161 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693000162 putative peptidoglycan binding site; other site 545693000163 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 545693000164 active site 545693000165 Isochorismatase family; Region: Isochorismatase; pfam00857 545693000166 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693000167 catalytic triad [active] 545693000168 conserved cis-peptide bond; other site 545693000169 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 545693000170 nucleoside/Zn binding site; other site 545693000171 dimer interface [polypeptide binding]; other site 545693000172 catalytic motif [active] 545693000173 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 545693000174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000175 Walker A motif; other site 545693000176 ATP binding site [chemical binding]; other site 545693000177 Walker B motif; other site 545693000178 arginine finger; other site 545693000179 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 545693000180 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 545693000181 recombination protein RecR; Reviewed; Region: recR; PRK00076 545693000182 RecR protein; Region: RecR; pfam02132 545693000183 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 545693000184 putative active site [active] 545693000185 putative metal-binding site [ion binding]; other site 545693000186 tetramer interface [polypeptide binding]; other site 545693000187 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 545693000188 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 545693000189 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 545693000190 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 545693000191 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 545693000192 homodimer interface [polypeptide binding]; other site 545693000193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000194 catalytic residue [active] 545693000195 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 545693000196 thymidylate kinase; Validated; Region: tmk; PRK00698 545693000197 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 545693000198 TMP-binding site; other site 545693000199 ATP-binding site [chemical binding]; other site 545693000200 Nitrogen regulatory protein P-II; Region: P-II; cl00412 545693000201 DNA polymerase III subunit delta'; Validated; Region: PRK08058 545693000202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693000203 PSP1 C-terminal conserved region; Region: PSP1; cl00770 545693000204 TSC-22/dip/bun family; Region: TSC22; cl01853 545693000205 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 545693000206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000207 S-adenosylmethionine binding site [chemical binding]; other site 545693000208 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 545693000209 GIY-YIG motif/motif A; other site 545693000210 putative active site [active] 545693000211 putative metal binding site [ion binding]; other site 545693000212 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693000213 Predicted methyltransferases [General function prediction only]; Region: COG0313 545693000214 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693000215 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693000216 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 545693000217 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 545693000218 active site 545693000219 HIGH motif; other site 545693000220 KMSKS motif; other site 545693000221 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 545693000222 tRNA binding surface [nucleotide binding]; other site 545693000223 anticodon binding site; other site 545693000224 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 545693000225 dimer interface [polypeptide binding]; other site 545693000226 putative tRNA-binding site [nucleotide binding]; other site 545693000227 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 545693000228 active site 545693000229 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 545693000230 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 545693000231 putative active site [active] 545693000232 putative metal binding site [ion binding]; other site 545693000233 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 545693000234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693000235 YabG peptidase U57; Region: Peptidase_U57; cl05250 545693000236 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 545693000237 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693000238 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 545693000239 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693000240 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693000241 pur operon repressor; Provisional; Region: PRK09213 545693000242 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 545693000243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000244 active site 545693000245 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693000246 homotrimer interaction site [polypeptide binding]; other site 545693000247 putative active site [active] 545693000248 SpoVG; Region: SpoVG; cl00915 545693000249 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 545693000250 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 545693000251 Substrate binding site; other site 545693000252 Mg++ binding site; other site 545693000253 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 545693000254 active site 545693000255 substrate binding site [chemical binding]; other site 545693000256 CoA binding site [chemical binding]; other site 545693000257 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 545693000258 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 545693000259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000260 active site 545693000261 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 545693000262 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 545693000263 5S rRNA interface [nucleotide binding]; other site 545693000264 CTC domain interface [polypeptide binding]; other site 545693000265 L16 interface [polypeptide binding]; other site 545693000266 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 545693000267 putative active site [active] 545693000268 catalytic residue [active] 545693000269 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 545693000270 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 545693000271 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 545693000272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693000273 ATP binding site [chemical binding]; other site 545693000274 putative Mg++ binding site [ion binding]; other site 545693000275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693000276 nucleotide binding region [chemical binding]; other site 545693000277 ATP-binding site [chemical binding]; other site 545693000278 TRCF domain; Region: TRCF; cl04088 545693000279 stage V sporulation protein T; Region: spore_V_T; TIGR02851 545693000280 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693000281 GAF domain; Region: GAF; cl15785 545693000282 MatE; Region: MatE; cl10513 545693000283 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 545693000284 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 545693000285 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693000286 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 545693000287 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 545693000288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 545693000289 YabP family; Region: YabP; cl06766 545693000290 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 545693000291 Septum formation initiator; Region: DivIC; cl11433 545693000292 hypothetical protein; Provisional; Region: PRK08582 545693000293 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 545693000294 RNA binding site [nucleotide binding]; other site 545693000295 stage II sporulation protein E; Region: spore_II_E; TIGR02865 545693000296 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 545693000297 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 545693000298 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 545693000299 metal ion-dependent adhesion site (MIDAS); other site 545693000300 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693000301 active site 545693000302 ATP binding site [chemical binding]; other site 545693000303 substrate binding site [chemical binding]; other site 545693000304 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 545693000305 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 545693000306 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 545693000307 Ligand Binding Site [chemical binding]; other site 545693000308 B3/4 domain; Region: B3_4; cl11458 545693000309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000310 active site 545693000311 FtsH Extracellular; Region: FtsH_ext; pfam06480 545693000312 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 545693000313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000314 Walker A motif; other site 545693000315 ATP binding site [chemical binding]; other site 545693000316 Walker B motif; other site 545693000317 arginine finger; other site 545693000318 Peptidase family M41; Region: Peptidase_M41; pfam01434 545693000319 Type III pantothenate kinase; Region: Pan_kinase; cl09130 545693000320 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 545693000321 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 545693000322 dimerization interface [polypeptide binding]; other site 545693000323 domain crossover interface; other site 545693000324 redox-dependent activation switch; other site 545693000325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 545693000326 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693000327 dimer interface [polypeptide binding]; other site 545693000328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000329 catalytic residue [active] 545693000330 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 545693000331 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 545693000332 chorismate binding enzyme; Region: Chorismate_bind; cl10555 545693000333 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 545693000334 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 545693000335 glutamine binding [chemical binding]; other site 545693000336 catalytic triad [active] 545693000337 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 545693000338 homodimer interface [polypeptide binding]; other site 545693000339 substrate-cofactor binding pocket; other site 545693000340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693000341 catalytic residue [active] 545693000342 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 545693000343 homooctamer interface [polypeptide binding]; other site 545693000344 active site 545693000345 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 545693000346 catalytic center binding site [active] 545693000347 ATP binding site [chemical binding]; other site 545693000348 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 545693000349 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 545693000350 dimer interface [polypeptide binding]; other site 545693000351 putative anticodon binding site; other site 545693000352 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 545693000353 motif 1; other site 545693000354 active site 545693000355 motif 2; other site 545693000356 motif 3; other site 545693000357 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 545693000358 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 545693000359 UvrB/uvrC motif; Region: UVR; pfam02151 545693000360 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 545693000361 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 545693000362 ADP binding site [chemical binding]; other site 545693000363 phosphagen binding site; other site 545693000364 substrate specificity loop; other site 545693000365 Clp protease ATP binding subunit; Region: clpC; CHL00095 545693000366 Clp amino terminal domain; Region: Clp_N; pfam02861 545693000367 Clp amino terminal domain; Region: Clp_N; pfam02861 545693000368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000369 Walker A motif; other site 545693000370 ATP binding site [chemical binding]; other site 545693000371 Walker B motif; other site 545693000372 arginine finger; other site 545693000373 UvrB/uvrC motif; Region: UVR; pfam02151 545693000374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000375 Walker A motif; other site 545693000376 ATP binding site [chemical binding]; other site 545693000377 Walker B motif; other site 545693000378 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 545693000379 DNA repair protein RadA; Provisional; Region: PRK11823 545693000380 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 545693000381 Walker A motif/ATP binding site; other site 545693000382 ATP binding site [chemical binding]; other site 545693000383 Walker B motif; other site 545693000384 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 545693000385 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 545693000386 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693000387 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 545693000388 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 545693000389 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 545693000390 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 545693000391 putative active site [active] 545693000392 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 545693000393 substrate binding site; other site 545693000394 dimer interface; other site 545693000395 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 545693000396 homotrimer interaction site [polypeptide binding]; other site 545693000397 zinc binding site [ion binding]; other site 545693000398 CDP-binding sites; other site 545693000399 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 545693000400 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 545693000401 HIGH motif; other site 545693000402 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 545693000403 active site 545693000404 KMSKS motif; other site 545693000405 serine O-acetyltransferase; Region: cysE; TIGR01172 545693000406 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 545693000407 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 545693000408 trimer interface [polypeptide binding]; other site 545693000409 active site 545693000410 substrate binding site [chemical binding]; other site 545693000411 CoA binding site [chemical binding]; other site 545693000412 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 545693000413 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 545693000414 active site 545693000415 HIGH motif; other site 545693000416 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 545693000417 KMSKS motif; other site 545693000418 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 545693000419 tRNA binding surface [nucleotide binding]; other site 545693000420 anticodon binding site; other site 545693000421 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 545693000422 dimerization interface [polypeptide binding]; other site 545693000423 active site 545693000424 metal binding site [ion binding]; metal-binding site 545693000425 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 545693000426 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 545693000427 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 545693000428 YacP-like NYN domain; Region: NYN_YacP; cl01491 545693000429 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693000430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693000432 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 545693000433 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 545693000434 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 545693000435 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 545693000436 putative homodimer interface [polypeptide binding]; other site 545693000437 KOW motif; Region: KOW; cl00354 545693000438 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 545693000439 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 545693000440 23S rRNA interface [nucleotide binding]; other site 545693000441 L7/L12 interface [polypeptide binding]; other site 545693000442 putative thiostrepton binding site; other site 545693000443 L25 interface [polypeptide binding]; other site 545693000444 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 545693000445 mRNA/rRNA interface [nucleotide binding]; other site 545693000446 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 545693000447 23S rRNA interface [nucleotide binding]; other site 545693000448 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 545693000449 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 545693000450 peripheral dimer interface [polypeptide binding]; other site 545693000451 core dimer interface [polypeptide binding]; other site 545693000452 L10 interface [polypeptide binding]; other site 545693000453 L11 interface [polypeptide binding]; other site 545693000454 putative EF-Tu interaction site [polypeptide binding]; other site 545693000455 putative EF-G interaction site [polypeptide binding]; other site 545693000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000457 S-adenosylmethionine binding site [chemical binding]; other site 545693000458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 545693000459 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 545693000460 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 545693000461 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 545693000462 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 545693000463 RPB12 interaction site [polypeptide binding]; other site 545693000464 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 545693000465 RPB10 interaction site [polypeptide binding]; other site 545693000466 RPB1 interaction site [polypeptide binding]; other site 545693000467 RPB11 interaction site [polypeptide binding]; other site 545693000468 RPB3 interaction site [polypeptide binding]; other site 545693000469 RPB12 interaction site [polypeptide binding]; other site 545693000470 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 545693000471 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 545693000472 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 545693000473 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 545693000474 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 545693000475 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 545693000476 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 545693000477 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 545693000478 G-loop; other site 545693000479 DNA binding site [nucleotide binding] 545693000480 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 545693000481 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 545693000482 S17 interaction site [polypeptide binding]; other site 545693000483 S8 interaction site; other site 545693000484 16S rRNA interaction site [nucleotide binding]; other site 545693000485 streptomycin interaction site [chemical binding]; other site 545693000486 23S rRNA interaction site [nucleotide binding]; other site 545693000487 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 545693000488 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 545693000489 elongation factor G; Reviewed; Region: PRK00007 545693000490 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 545693000491 G1 box; other site 545693000492 putative GEF interaction site [polypeptide binding]; other site 545693000493 GTP/Mg2+ binding site [chemical binding]; other site 545693000494 Switch I region; other site 545693000495 G2 box; other site 545693000496 G3 box; other site 545693000497 Switch II region; other site 545693000498 G4 box; other site 545693000499 G5 box; other site 545693000500 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 545693000501 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 545693000502 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 545693000503 elongation factor Tu; Reviewed; Region: PRK00049 545693000504 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 545693000505 G1 box; other site 545693000506 GEF interaction site [polypeptide binding]; other site 545693000507 GTP/Mg2+ binding site [chemical binding]; other site 545693000508 Switch I region; other site 545693000509 G2 box; other site 545693000510 G3 box; other site 545693000511 Switch II region; other site 545693000512 G4 box; other site 545693000513 G5 box; other site 545693000514 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 545693000515 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 545693000516 Antibiotic Binding Site [chemical binding]; other site 545693000517 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 545693000518 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 545693000519 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 545693000520 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 545693000521 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 545693000522 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 545693000523 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 545693000524 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 545693000525 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 545693000526 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 545693000527 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 545693000528 putative translocon binding site; other site 545693000529 protein-rRNA interface [nucleotide binding]; other site 545693000530 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 545693000531 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 545693000532 G-X-X-G motif; other site 545693000533 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 545693000534 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 545693000535 23S rRNA interface [nucleotide binding]; other site 545693000536 5S rRNA interface [nucleotide binding]; other site 545693000537 putative antibiotic binding site [chemical binding]; other site 545693000538 L25 interface [polypeptide binding]; other site 545693000539 L27 interface [polypeptide binding]; other site 545693000540 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 545693000541 23S rRNA interface [nucleotide binding]; other site 545693000542 putative translocon interaction site; other site 545693000543 signal recognition particle (SRP54) interaction site; other site 545693000544 L23 interface [polypeptide binding]; other site 545693000545 trigger factor interaction site; other site 545693000546 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 545693000547 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 545693000548 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 545693000549 KOW motif; Region: KOW; cl00354 545693000550 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 545693000551 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 545693000552 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 545693000553 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 545693000554 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 545693000555 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 545693000556 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 545693000557 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 545693000558 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 545693000559 23S rRNA interface [nucleotide binding]; other site 545693000560 5S rRNA interface [nucleotide binding]; other site 545693000561 L27 interface [polypeptide binding]; other site 545693000562 L5 interface [polypeptide binding]; other site 545693000563 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 545693000564 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 545693000565 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 545693000566 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 545693000567 23S rRNA binding site [nucleotide binding]; other site 545693000568 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 545693000569 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 545693000570 SecY translocase; Region: SecY; pfam00344 545693000571 adenylate kinase; Reviewed; Region: adk; PRK00279 545693000572 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 545693000573 AMP-binding site [chemical binding]; other site 545693000574 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 545693000575 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693000576 active site 545693000577 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 545693000578 rRNA binding site [nucleotide binding]; other site 545693000579 predicted 30S ribosome binding site; other site 545693000580 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 545693000581 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 545693000582 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 545693000583 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 545693000584 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 545693000585 alphaNTD homodimer interface [polypeptide binding]; other site 545693000586 alphaNTD - beta interaction site [polypeptide binding]; other site 545693000587 alphaNTD - beta' interaction site [polypeptide binding]; other site 545693000588 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 545693000589 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 545693000590 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 545693000591 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 545693000592 Walker A/P-loop; other site 545693000593 ATP binding site [chemical binding]; other site 545693000594 Q-loop/lid; other site 545693000595 ABC transporter signature motif; other site 545693000596 Walker B; other site 545693000597 D-loop; other site 545693000598 H-loop/switch region; other site 545693000599 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 545693000600 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 545693000601 Walker A/P-loop; other site 545693000602 ATP binding site [chemical binding]; other site 545693000603 Q-loop/lid; other site 545693000604 ABC transporter signature motif; other site 545693000605 Walker B; other site 545693000606 D-loop; other site 545693000607 H-loop/switch region; other site 545693000608 Cobalt transport protein; Region: CbiQ; cl00463 545693000609 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 545693000610 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 545693000611 dimerization interface 3.5A [polypeptide binding]; other site 545693000612 active site 545693000613 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 545693000614 23S rRNA interface [nucleotide binding]; other site 545693000615 L3 interface [polypeptide binding]; other site 545693000616 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 545693000617 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 545693000618 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693000619 active site 545693000620 metal binding site [ion binding]; metal-binding site 545693000621 antiporter inner membrane protein; Provisional; Region: PRK11670 545693000622 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 545693000623 Walker A motif; other site 545693000624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693000625 Helix-turn-helix domains; Region: HTH; cl00088 545693000626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693000627 dimerization interface [polypeptide binding]; other site 545693000628 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 545693000629 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 545693000630 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 545693000631 Arginase family; Region: Arginase; cl00306 545693000632 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693000633 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 545693000634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693000636 DNA binding residues [nucleotide binding] 545693000637 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 545693000638 Uncharacterized conserved protein [Function unknown]; Region: COG1624 545693000639 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 545693000641 YbbR-like protein; Region: YbbR; pfam07949 545693000642 YbbR-like protein; Region: YbbR; pfam07949 545693000643 YbbR-like protein; Region: YbbR; pfam07949 545693000644 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 545693000645 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 545693000646 active site 545693000647 substrate binding site [chemical binding]; other site 545693000648 metal binding site [ion binding]; metal-binding site 545693000649 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 545693000650 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 545693000651 glutaminase active site [active] 545693000652 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 545693000653 dimer interface [polypeptide binding]; other site 545693000654 active site 545693000655 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 545693000656 dimer interface [polypeptide binding]; other site 545693000657 active site 545693000658 Transcriptional regulator; Region: Transcrip_reg; cl00361 545693000659 Bacterial SH3 domain; Region: SH3_3; cl02551 545693000660 Bacterial SH3 domain; Region: SH3_3; cl02551 545693000661 Bacterial SH3 domain; Region: SH3_3; cl02551 545693000662 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693000663 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 545693000664 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693000665 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 545693000666 active site 545693000667 P-loop; other site 545693000668 phosphorylation site [posttranslational modification] 545693000669 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693000670 active site 545693000671 phosphorylation site [posttranslational modification] 545693000672 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693000673 Helix-turn-helix domains; Region: HTH; cl00088 545693000674 PRD domain; Region: PRD; cl15445 545693000675 PRD domain; Region: PRD; cl15445 545693000676 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693000677 active site 545693000678 P-loop; other site 545693000679 phosphorylation site [posttranslational modification] 545693000680 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 545693000681 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 545693000682 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 545693000683 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 545693000684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693000685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693000686 active site 545693000687 metal binding site [ion binding]; metal-binding site 545693000688 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693000689 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 545693000690 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 545693000691 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 545693000692 Sulfatase; Region: Sulfatase; cl10460 545693000693 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693000694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693000695 non-specific DNA binding site [nucleotide binding]; other site 545693000696 salt bridge; other site 545693000697 sequence-specific DNA binding site [nucleotide binding]; other site 545693000698 Cupin domain; Region: Cupin_2; cl09118 545693000699 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 545693000700 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 545693000701 Walker A/P-loop; other site 545693000702 ATP binding site [chemical binding]; other site 545693000703 Q-loop/lid; other site 545693000704 ABC transporter signature motif; other site 545693000705 Walker B; other site 545693000706 D-loop; other site 545693000707 H-loop/switch region; other site 545693000708 TOBE domain; Region: TOBE_2; cl01440 545693000709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 545693000710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693000711 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 545693000712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693000713 dimer interface [polypeptide binding]; other site 545693000714 conserved gate region; other site 545693000715 putative PBP binding loops; other site 545693000716 ABC-ATPase subunit interface; other site 545693000717 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 545693000718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693000719 OpgC protein; Region: OpgC_C; cl00792 545693000720 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693000721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693000722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693000723 active site 545693000724 phosphorylation site [posttranslational modification] 545693000725 intermolecular recognition site; other site 545693000726 dimerization interface [polypeptide binding]; other site 545693000727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693000728 DNA binding site [nucleotide binding] 545693000729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693000730 dimer interface [polypeptide binding]; other site 545693000731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693000732 phosphorylation site [posttranslational modification] 545693000733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000734 ATP binding site [chemical binding]; other site 545693000735 Mg2+ binding site [ion binding]; other site 545693000736 G-X-G motif; other site 545693000737 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 545693000738 ApbE family; Region: ApbE; cl00643 545693000739 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 545693000740 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 545693000741 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693000742 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 545693000743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693000744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693000745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693000746 helicase 45; Provisional; Region: PTZ00424 545693000747 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693000748 ATP binding site [chemical binding]; other site 545693000749 Mg++ binding site [ion binding]; other site 545693000750 motif III; other site 545693000751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693000752 nucleotide binding region [chemical binding]; other site 545693000753 ATP-binding site [chemical binding]; other site 545693000754 UV-endonuclease UvdE; Region: UvdE; cl10036 545693000755 Rhomboid family; Region: Rhomboid; cl11446 545693000756 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 545693000757 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 545693000758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 545693000759 alanine racemase; Reviewed; Region: alr; PRK00053 545693000760 active site 545693000761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693000762 dimer interface [polypeptide binding]; other site 545693000763 substrate binding site [chemical binding]; other site 545693000764 catalytic residues [active] 545693000765 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 545693000766 PemK-like protein; Region: PemK; cl00995 545693000767 Rsbr N terminal; Region: Rsbr_N; pfam08678 545693000768 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000769 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693000770 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 545693000771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000772 ATP binding site [chemical binding]; other site 545693000773 Mg2+ binding site [ion binding]; other site 545693000774 G-X-G motif; other site 545693000775 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 545693000776 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 545693000777 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 545693000778 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 545693000779 anti sigma factor interaction site; other site 545693000780 regulatory phosphorylation site [posttranslational modification]; other site 545693000781 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 545693000782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000783 ATP binding site [chemical binding]; other site 545693000784 Mg2+ binding site [ion binding]; other site 545693000785 G-X-G motif; other site 545693000786 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 545693000787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693000788 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693000789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693000790 DNA binding residues [nucleotide binding] 545693000791 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 545693000792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 545693000793 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 545693000794 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 545693000795 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 545693000796 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 545693000797 RNA binding site [nucleotide binding]; other site 545693000798 SprT homologues; Region: SprT; cl01182 545693000799 hypothetical protein; Provisional; Region: PRK04351 545693000800 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 545693000801 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 545693000802 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693000803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693000804 Coenzyme A binding pocket [chemical binding]; other site 545693000805 UGMP family protein; Validated; Region: PRK09604 545693000806 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 545693000807 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693000808 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693000809 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693000810 ABC transporter; Region: ABC_tran_2; pfam12848 545693000811 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693000812 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 545693000813 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 545693000814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693000815 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 545693000816 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 545693000817 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 545693000818 CAAX protease self-immunity; Region: Abi; cl00558 545693000819 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 545693000820 oligomerisation interface [polypeptide binding]; other site 545693000821 mobile loop; other site 545693000822 roof hairpin; other site 545693000823 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 545693000824 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 545693000825 ring oligomerisation interface [polypeptide binding]; other site 545693000826 ATP/Mg binding site [chemical binding]; other site 545693000827 stacking interactions; other site 545693000828 hinge regions; other site 545693000829 MoxR-like ATPases [General function prediction only]; Region: COG0714 545693000830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693000831 Walker A motif; other site 545693000832 ATP binding site [chemical binding]; other site 545693000833 Walker B motif; other site 545693000834 arginine finger; other site 545693000835 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 545693000836 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 545693000837 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 545693000838 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 545693000839 GMP synthase; Reviewed; Region: guaA; PRK00074 545693000840 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 545693000841 AMP/PPi binding site [chemical binding]; other site 545693000842 candidate oxyanion hole; other site 545693000843 catalytic triad [active] 545693000844 potential glutamine specificity residues [chemical binding]; other site 545693000845 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 545693000846 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 545693000847 ATP Binding subdomain [chemical binding]; other site 545693000848 Ligand Binding sites [chemical binding]; other site 545693000849 Dimerization subdomain; other site 545693000850 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693000851 NETI protein; Region: NETI; pfam14044 545693000852 AIR carboxylase; Region: AIRC; cl00310 545693000853 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 545693000854 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693000855 adenylosuccinate lyase; Provisional; Region: PRK07492 545693000856 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 545693000857 tetramer interface [polypeptide binding]; other site 545693000858 active site 545693000859 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 545693000860 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 545693000861 ATP binding site [chemical binding]; other site 545693000862 active site 545693000863 substrate binding site [chemical binding]; other site 545693000864 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 545693000865 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 545693000866 putative active site [active] 545693000867 catalytic triad [active] 545693000868 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 545693000869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 545693000870 dimerization interface [polypeptide binding]; other site 545693000871 ATP binding site [chemical binding]; other site 545693000872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 545693000873 dimerization interface [polypeptide binding]; other site 545693000874 ATP binding site [chemical binding]; other site 545693000875 amidophosphoribosyltransferase; Provisional; Region: PRK07631 545693000876 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 545693000877 active site 545693000878 tetramer interface [polypeptide binding]; other site 545693000879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693000880 active site 545693000881 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 545693000882 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 545693000883 dimerization interface [polypeptide binding]; other site 545693000884 putative ATP binding site [chemical binding]; other site 545693000885 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 545693000886 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 545693000887 active site 545693000888 substrate binding site [chemical binding]; other site 545693000889 cosubstrate binding site; other site 545693000890 catalytic site [active] 545693000891 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 545693000892 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 545693000893 purine monophosphate binding site [chemical binding]; other site 545693000894 dimer interface [polypeptide binding]; other site 545693000895 putative catalytic residues [active] 545693000896 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 545693000897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 545693000898 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 545693000899 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 545693000900 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693000901 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 545693000902 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 545693000903 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 545693000904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693000905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693000906 active site 545693000907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693000908 Helix-turn-helix domains; Region: HTH; cl00088 545693000909 glycyl-tRNA synthetase; Provisional; Region: PRK04173 545693000910 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 545693000911 motif 1; other site 545693000912 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 545693000913 active site 545693000914 motif 2; other site 545693000915 motif 3; other site 545693000916 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 545693000917 anticodon binding site; other site 545693000918 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 545693000919 substrate binding site [chemical binding]; other site 545693000920 putative active site [active] 545693000921 dimer interface [polypeptide binding]; other site 545693000922 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 545693000923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693000924 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 545693000925 Family description; Region: UvrD_C_2; cl15862 545693000926 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 545693000927 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 545693000928 nucleotide binding pocket [chemical binding]; other site 545693000929 K-X-D-G motif; other site 545693000930 catalytic site [active] 545693000931 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 545693000932 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 545693000933 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 545693000934 Dimer interface [polypeptide binding]; other site 545693000935 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 545693000936 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 545693000937 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 545693000938 Amidase; Region: Amidase; cl11426 545693000939 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 545693000940 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 545693000941 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 545693000942 GatB domain; Region: GatB_Yqey; cl11497 545693000943 putative lipid kinase; Reviewed; Region: PRK13337 545693000944 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 545693000945 TRAM domain; Region: TRAM; cl01282 545693000946 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 545693000947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693000948 S-adenosylmethionine binding site [chemical binding]; other site 545693000949 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693000950 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693000951 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693000952 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693000953 Dynamin family; Region: Dynamin_N; pfam00350 545693000954 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693000955 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 545693000956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693000957 dimerization interface [polypeptide binding]; other site 545693000958 sensory histidine kinase AtoS; Provisional; Region: PRK11360 545693000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693000960 dimer interface [polypeptide binding]; other site 545693000961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693000962 ATP binding site [chemical binding]; other site 545693000963 Mg2+ binding site [ion binding]; other site 545693000964 G-X-G motif; other site 545693000965 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693000966 active site 545693000967 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 545693000968 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693000969 Nitronate monooxygenase; Region: NMO; pfam03060 545693000970 FMN binding site [chemical binding]; other site 545693000971 substrate binding site [chemical binding]; other site 545693000972 putative catalytic residue [active] 545693000973 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693000974 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 545693000975 DNA binding residues [nucleotide binding] 545693000976 drug binding residues [chemical binding]; other site 545693000977 dimer interface [polypeptide binding]; other site 545693000978 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693000979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693000980 putative substrate translocation pore; other site 545693000981 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 545693000982 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693000983 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 545693000984 Walker A/P-loop; other site 545693000985 ATP binding site [chemical binding]; other site 545693000986 Q-loop/lid; other site 545693000987 ABC transporter signature motif; other site 545693000988 Walker B; other site 545693000989 D-loop; other site 545693000990 H-loop/switch region; other site 545693000991 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693000992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693000993 substrate binding pocket [chemical binding]; other site 545693000994 membrane-bound complex binding site; other site 545693000995 hinge residues; other site 545693000996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693000997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693000998 dimer interface [polypeptide binding]; other site 545693000999 conserved gate region; other site 545693001000 putative PBP binding loops; other site 545693001001 ABC-ATPase subunit interface; other site 545693001002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693001003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001004 dimer interface [polypeptide binding]; other site 545693001005 conserved gate region; other site 545693001006 putative PBP binding loops; other site 545693001007 ABC-ATPase subunit interface; other site 545693001008 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693001009 Protein of unknown function (DUF445); Region: DUF445; pfam04286 545693001010 Predicted membrane protein [Function unknown]; Region: COG3212 545693001011 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693001012 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693001013 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693001014 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693001015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693001016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001017 dimerization interface [polypeptide binding]; other site 545693001018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001019 dimer interface [polypeptide binding]; other site 545693001020 phosphorylation site [posttranslational modification] 545693001021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001022 ATP binding site [chemical binding]; other site 545693001023 Mg2+ binding site [ion binding]; other site 545693001024 G-X-G motif; other site 545693001025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001027 active site 545693001028 phosphorylation site [posttranslational modification] 545693001029 intermolecular recognition site; other site 545693001030 dimerization interface [polypeptide binding]; other site 545693001031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693001032 DNA binding site [nucleotide binding] 545693001033 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693001034 active site 545693001035 OsmC-like protein; Region: OsmC; cl00767 545693001036 High-affinity nickel-transport protein; Region: NicO; cl00964 545693001037 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 545693001038 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 545693001039 metal binding site [ion binding]; metal-binding site 545693001040 dimer interface [polypeptide binding]; other site 545693001041 DoxX; Region: DoxX; cl00976 545693001042 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 545693001043 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693001044 proposed catalytic triad [active] 545693001045 conserved cys residue [active] 545693001046 DinB superfamily; Region: DinB_2; pfam12867 545693001047 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693001048 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 545693001049 active site flap/lid [active] 545693001050 nucleophilic elbow; other site 545693001051 catalytic triad [active] 545693001052 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693001053 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 545693001054 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 545693001055 Occludin homology domain; Region: Occludin_ELL; pfam07303 545693001056 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 545693001057 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693001058 metal binding site [ion binding]; metal-binding site 545693001059 Uncharacterized conserved protein [Function unknown]; Region: COG1633 545693001060 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 545693001061 dinuclear metal binding motif [ion binding]; other site 545693001062 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 545693001063 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 545693001064 sensory histidine kinase DcuS; Provisional; Region: PRK11086 545693001065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693001066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001067 ATP binding site [chemical binding]; other site 545693001068 Mg2+ binding site [ion binding]; other site 545693001069 G-X-G motif; other site 545693001070 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693001071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001072 active site 545693001073 phosphorylation site [posttranslational modification] 545693001074 intermolecular recognition site; other site 545693001075 dimerization interface [polypeptide binding]; other site 545693001076 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 545693001077 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 545693001078 B12 binding site [chemical binding]; other site 545693001079 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693001080 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693001081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693001082 putative active site [active] 545693001083 heme pocket [chemical binding]; other site 545693001084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001085 dimer interface [polypeptide binding]; other site 545693001086 phosphorylation site [posttranslational modification] 545693001087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001088 ATP binding site [chemical binding]; other site 545693001089 Mg2+ binding site [ion binding]; other site 545693001090 G-X-G motif; other site 545693001091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693001093 ATP binding site [chemical binding]; other site 545693001094 putative Mg++ binding site [ion binding]; other site 545693001095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693001096 nucleotide binding region [chemical binding]; other site 545693001097 ATP-binding site [chemical binding]; other site 545693001098 Proteins of 100 residues with WXG; Region: WXG100; cl02005 545693001099 SseB protein; Region: SseB; cl06279 545693001100 Proteins of 100 residues with WXG; Region: WXG100; cl02005 545693001101 Ubiquitin-like proteins; Region: UBQ; cl00155 545693001102 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 545693001103 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 545693001104 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 545693001105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001107 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 545693001108 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693001109 hypothetical protein; Provisional; Region: PRK11281 545693001110 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 545693001111 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 545693001112 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 545693001113 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 545693001114 Endonuclease I; Region: Endonuclease_1; cl01003 545693001115 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 545693001116 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 545693001117 starch-binding site 2 [chemical binding]; other site 545693001118 starch-binding site 1 [chemical binding]; other site 545693001119 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 545693001120 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 545693001121 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 545693001122 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693001123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001124 Walker A/P-loop; other site 545693001125 ATP binding site [chemical binding]; other site 545693001126 Q-loop/lid; other site 545693001127 ABC transporter signature motif; other site 545693001128 Walker B; other site 545693001129 D-loop; other site 545693001130 H-loop/switch region; other site 545693001131 ABC transporter; Region: ABC_tran_2; pfam12848 545693001132 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693001133 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 545693001134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001135 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 545693001136 active site 545693001137 dimer interface [polypeptide binding]; other site 545693001138 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 545693001139 Helix-turn-helix domains; Region: HTH; cl00088 545693001140 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693001141 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 545693001142 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 545693001143 heme-binding site [chemical binding]; other site 545693001144 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 545693001145 FAD binding pocket [chemical binding]; other site 545693001146 FAD binding motif [chemical binding]; other site 545693001147 phosphate binding motif [ion binding]; other site 545693001148 beta-alpha-beta structure motif; other site 545693001149 NAD binding pocket [chemical binding]; other site 545693001150 Heme binding pocket [chemical binding]; other site 545693001151 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 545693001152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001153 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693001154 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 545693001155 proposed catalytic triad [active] 545693001156 conserved cys residue [active] 545693001157 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693001158 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 545693001159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693001160 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 545693001161 active site 545693001162 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693001163 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 545693001164 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693001165 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 545693001166 active site 545693001167 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 545693001168 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 545693001169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693001170 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693001171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693001172 dimerization interface [polypeptide binding]; other site 545693001173 putative DNA binding site [nucleotide binding]; other site 545693001174 putative Zn2+ binding site [ion binding]; other site 545693001175 Cation efflux family; Region: Cation_efflux; cl00316 545693001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693001178 putative substrate translocation pore; other site 545693001179 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 545693001180 OsmC-like protein; Region: OsmC; cl00767 545693001181 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 545693001182 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693001183 calcium/proton exchanger (cax); Region: cax; TIGR00378 545693001184 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693001185 YfkD-like protein; Region: YfkD; pfam14167 545693001186 Radical SAM superfamily; Region: Radical_SAM; pfam04055 545693001187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693001188 FeS/SAM binding site; other site 545693001189 YfkB-like domain; Region: YfkB; pfam08756 545693001190 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 545693001191 Fumarase C-terminus; Region: Fumerase_C; cl00795 545693001192 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 545693001193 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 545693001194 NodB motif; other site 545693001195 active site 545693001196 catalytic site [active] 545693001197 Cd binding site [ion binding]; other site 545693001198 TRAM domain; Region: TRAM; cl01282 545693001199 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 545693001200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693001201 S-adenosylmethionine binding site [chemical binding]; other site 545693001202 putative FAD-dependent oxidoreductase, frameshift 545693001203 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 545693001204 Cache domain; Region: Cache_1; pfam02743 545693001205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693001206 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693001207 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 545693001208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693001209 phosphorylation site [posttranslational modification] 545693001210 dimer interface [polypeptide binding]; other site 545693001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001212 ATP binding site [chemical binding]; other site 545693001213 Mg2+ binding site [ion binding]; other site 545693001214 G-X-G motif; other site 545693001215 YfhE-like protein; Region: YfhE; pfam14152 545693001216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693001217 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 545693001218 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 545693001219 active site 545693001220 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 545693001221 TIGR01777 family protein; Region: yfcH 545693001222 putative NAD(P) binding site [chemical binding]; other site 545693001223 putative active site [active] 545693001224 RecX family; Region: RecX; cl00936 545693001225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001226 short chain dehydrogenase; Provisional; Region: PRK06924 545693001227 NAD(P) binding site [chemical binding]; other site 545693001228 active site 545693001229 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 545693001230 Small acid-soluble spore protein K family; Region: SspK; cl11509 545693001231 WVELL protein; Region: WVELL; pfam14043 545693001232 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 545693001233 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 545693001234 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 545693001235 minor groove reading motif; other site 545693001236 helix-hairpin-helix signature motif; other site 545693001237 substrate binding pocket [chemical binding]; other site 545693001238 active site 545693001239 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 545693001240 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 545693001241 DNA binding and oxoG recognition site [nucleotide binding] 545693001242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693001243 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 545693001244 putative NAD(P) binding site [chemical binding]; other site 545693001245 active site 545693001246 YgaB-like protein; Region: YgaB; pfam14182 545693001247 Protein of unknown function (DUF402); Region: DUF402; cl00979 545693001248 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693001249 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693001250 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 545693001251 Walker A/P-loop; other site 545693001252 ATP binding site [chemical binding]; other site 545693001253 Q-loop/lid; other site 545693001254 ABC transporter signature motif; other site 545693001255 Walker B; other site 545693001256 D-loop; other site 545693001257 H-loop/switch region; other site 545693001258 Predicted membrane protein [Function unknown]; Region: COG4129 545693001259 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 545693001260 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 545693001261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001262 inhibitor-cofactor binding pocket; inhibition site 545693001263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001264 catalytic residue [active] 545693001265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001266 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 545693001267 Walker A/P-loop; other site 545693001268 ATP binding site [chemical binding]; other site 545693001269 Q-loop/lid; other site 545693001270 ABC transporter signature motif; other site 545693001271 Walker B; other site 545693001272 D-loop; other site 545693001273 H-loop/switch region; other site 545693001274 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 545693001275 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 545693001276 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 545693001277 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 545693001278 Ion channel; Region: Ion_trans_2; cl11596 545693001279 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 545693001280 catalytic triad [active] 545693001281 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693001282 metal binding site 2 [ion binding]; metal-binding site 545693001283 putative DNA binding helix; other site 545693001284 metal binding site 1 [ion binding]; metal-binding site 545693001285 dimer interface [polypeptide binding]; other site 545693001286 structural Zn2+ binding site [ion binding]; other site 545693001287 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 545693001288 B3/4 domain; Region: B3_4; cl11458 545693001289 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 545693001290 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 545693001291 NlpC/P60 family; Region: NLPC_P60; cl11438 545693001292 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 545693001293 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 545693001294 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 545693001295 Uncharacterized conserved protein [Function unknown]; Region: COG2718 545693001296 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 545693001297 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693001298 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693001299 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693001300 Cation efflux family; Region: Cation_efflux; cl00316 545693001301 VanZ like family; Region: VanZ; cl01971 545693001302 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 545693001303 ThiC-associated domain; Region: ThiC-associated; pfam13667 545693001304 ThiC family; Region: ThiC; cl08031 545693001305 Bacitracin resistance protein BacA; Region: BacA; cl00858 545693001306 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693001307 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693001308 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 545693001309 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693001310 EcsC protein family; Region: EcsC; pfam12787 545693001311 amino acid transporter; Region: 2A0306; TIGR00909 545693001312 Spore germination protein; Region: Spore_permease; cl15802 545693001313 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 545693001314 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 545693001315 biotin synthase; Validated; Region: PRK06256 545693001316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693001317 FeS/SAM binding site; other site 545693001318 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 545693001319 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 545693001320 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693001321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001322 Walker A/P-loop; other site 545693001323 ATP binding site [chemical binding]; other site 545693001324 Q-loop/lid; other site 545693001325 ABC transporter signature motif; other site 545693001326 Walker B; other site 545693001327 D-loop; other site 545693001328 H-loop/switch region; other site 545693001329 TOBE domain; Region: TOBE_2; cl01440 545693001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001331 putative PBP binding loops; other site 545693001332 dimer interface [polypeptide binding]; other site 545693001333 ABC-ATPase subunit interface; other site 545693001334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001335 dimer interface [polypeptide binding]; other site 545693001336 conserved gate region; other site 545693001337 putative PBP binding loops; other site 545693001338 ABC-ATPase subunit interface; other site 545693001339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693001340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693001341 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693001342 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 545693001343 active site 545693001344 catalytic site [active] 545693001345 metal binding site [ion binding]; metal-binding site 545693001346 dimer interface [polypeptide binding]; other site 545693001347 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 545693001348 Protein of unknown function (DUF819); Region: DUF819; cl02317 545693001349 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 545693001350 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 545693001351 active site 545693001352 NlpC/P60 family; Region: NLPC_P60; cl11438 545693001353 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693001354 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 545693001355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693001356 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 545693001357 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693001358 putative peptidoglycan binding site; other site 545693001359 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693001360 putative peptidoglycan binding site; other site 545693001361 3D domain; Region: 3D; cl01439 545693001362 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 545693001363 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 545693001364 Bacterial SH3 domain; Region: SH3_3; cl02551 545693001365 Bacterial SH3 domain; Region: SH3_3; cl02551 545693001366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001367 Coenzyme A binding pocket [chemical binding]; other site 545693001368 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693001369 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693001370 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 545693001371 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693001372 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693001373 putative active site [active] 545693001374 catalytic site [active] 545693001375 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693001376 putative active site [active] 545693001377 catalytic site [active] 545693001378 Heat induced stress protein YflT; Region: YflT; pfam11181 545693001379 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693001380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001382 DNA binding site [nucleotide binding] 545693001383 domain linker motif; other site 545693001384 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693001385 dimerization interface [polypeptide binding]; other site 545693001386 ligand binding site [chemical binding]; other site 545693001387 polyol permease family; Region: 2A0118; TIGR00897 545693001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001389 putative substrate translocation pore; other site 545693001390 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693001391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001392 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693001393 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693001394 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693001395 substrate binding site [chemical binding]; other site 545693001396 ATP binding site [chemical binding]; other site 545693001397 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693001398 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693001399 tetrameric interface [polypeptide binding]; other site 545693001400 NAD binding site [chemical binding]; other site 545693001401 catalytic residues [active] 545693001402 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 545693001403 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693001404 PYR/PP interface [polypeptide binding]; other site 545693001405 dimer interface [polypeptide binding]; other site 545693001406 TPP binding site [chemical binding]; other site 545693001407 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693001408 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 545693001409 TPP-binding site; other site 545693001410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693001411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001413 DNA binding site [nucleotide binding] 545693001414 domain linker motif; other site 545693001415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693001416 dimerization interface [polypeptide binding]; other site 545693001417 ligand binding site [chemical binding]; other site 545693001418 KduI/IolB family; Region: KduI; cl01508 545693001419 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001420 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001421 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693001422 Helix-turn-helix domains; Region: HTH; cl00088 545693001423 QueT transporter; Region: QueT; cl01932 545693001424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693001425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693001427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693001428 Helix-turn-helix domains; Region: HTH; cl00088 545693001429 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 545693001430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693001431 RNA binding surface [nucleotide binding]; other site 545693001432 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 545693001433 probable active site [active] 545693001434 TIGR01177 family protein; Region: TIGR01177 545693001435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001436 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 545693001437 cell division protein FtsZ; Region: ftsZ; TIGR00065 545693001438 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 545693001439 nucleotide binding site [chemical binding]; other site 545693001440 SulA interaction site; other site 545693001441 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 545693001442 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 545693001443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001444 Coenzyme A binding pocket [chemical binding]; other site 545693001445 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 545693001446 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 545693001447 active site 545693001448 EamA-like transporter family; Region: EamA; cl01037 545693001449 SET domain; Region: SET; cl02566 545693001450 Domain of unknown function DUF20; Region: UPF0118; pfam01594 545693001451 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 545693001452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001453 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693001454 NAD(P) binding site [chemical binding]; other site 545693001455 glycolate transporter; Provisional; Region: PRK09695 545693001456 L-lactate permease; Region: Lactate_perm; cl00701 545693001457 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 545693001458 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 545693001459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693001460 NAD binding site [chemical binding]; other site 545693001461 dimer interface [polypeptide binding]; other site 545693001462 substrate binding site [chemical binding]; other site 545693001463 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693001464 Cation efflux family; Region: Cation_efflux; cl00316 545693001465 Cache domain; Region: Cache_1; pfam02743 545693001466 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 545693001467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001468 dimerization interface [polypeptide binding]; other site 545693001469 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 545693001470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 545693001471 dimer interface [polypeptide binding]; other site 545693001472 putative CheW interface [polypeptide binding]; other site 545693001473 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 545693001474 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 545693001475 active site 545693001476 SurA N-terminal domain; Region: SurA_N_3; cl07813 545693001477 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693001478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693001479 Coenzyme A binding pocket [chemical binding]; other site 545693001480 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693001481 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 545693001482 putative active site [active] 545693001483 catalytic triad [active] 545693001484 putative dimer interface [polypeptide binding]; other site 545693001485 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 545693001486 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 545693001487 amphipathic channel; other site 545693001488 Asn-Pro-Ala signature motifs; other site 545693001489 glycerol kinase; Provisional; Region: glpK; PRK00047 545693001490 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 545693001491 N- and C-terminal domain interface [polypeptide binding]; other site 545693001492 active site 545693001493 MgATP binding site [chemical binding]; other site 545693001494 catalytic site [active] 545693001495 metal binding site [ion binding]; metal-binding site 545693001496 glycerol binding site [chemical binding]; other site 545693001497 homotetramer interface [polypeptide binding]; other site 545693001498 homodimer interface [polypeptide binding]; other site 545693001499 FBP binding site [chemical binding]; other site 545693001500 protein IIAGlc interface [polypeptide binding]; other site 545693001501 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 545693001502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001503 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 545693001504 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 545693001505 active site 545693001506 substrate binding site [chemical binding]; other site 545693001507 metal binding site [ion binding]; metal-binding site 545693001508 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693001509 YhdB-like protein; Region: YhdB; pfam14148 545693001510 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 545693001511 SpoVR like protein; Region: SpoVR; pfam04293 545693001512 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693001513 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693001514 Helix-turn-helix domains; Region: HTH; cl00088 545693001515 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 545693001516 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 545693001517 putative NADP binding site [chemical binding]; other site 545693001518 putative dimer interface [polypeptide binding]; other site 545693001519 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 545693001520 active site 545693001521 dimerization interface [polypeptide binding]; other site 545693001522 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693001523 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 545693001524 Walker A/P-loop; other site 545693001525 ATP binding site [chemical binding]; other site 545693001526 Q-loop/lid; other site 545693001527 ABC transporter signature motif; other site 545693001528 Walker B; other site 545693001529 D-loop; other site 545693001530 H-loop/switch region; other site 545693001531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693001532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001533 dimer interface [polypeptide binding]; other site 545693001534 conserved gate region; other site 545693001535 putative PBP binding loops; other site 545693001536 ABC-ATPase subunit interface; other site 545693001537 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693001538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693001539 substrate binding pocket [chemical binding]; other site 545693001540 membrane-bound complex binding site; other site 545693001541 hinge residues; other site 545693001542 CrcB-like protein; Region: CRCB; cl09114 545693001543 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 545693001544 thiamine phosphate binding site [chemical binding]; other site 545693001545 active site 545693001546 pyrophosphate binding site [ion binding]; other site 545693001547 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 545693001548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001549 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 545693001550 thiS-thiF/thiG interaction site; other site 545693001551 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 545693001552 ThiS interaction site; other site 545693001553 putative active site [active] 545693001554 tetramer interface [polypeptide binding]; other site 545693001555 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 545693001556 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 545693001557 ATP binding site [chemical binding]; other site 545693001558 substrate interface [chemical binding]; other site 545693001559 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 545693001560 dimer interface [polypeptide binding]; other site 545693001561 substrate binding site [chemical binding]; other site 545693001562 ATP binding site [chemical binding]; other site 545693001563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693001564 catalytic core [active] 545693001565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693001566 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693001567 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693001568 NAD binding site [chemical binding]; other site 545693001569 substrate binding site [chemical binding]; other site 545693001570 putative active site [active] 545693001571 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693001572 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693001573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693001574 Transporter associated domain; Region: CorC_HlyC; cl08393 545693001575 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693001576 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 545693001577 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693001578 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 545693001579 Walker A/P-loop; other site 545693001580 ATP binding site [chemical binding]; other site 545693001581 Q-loop/lid; other site 545693001582 ABC transporter signature motif; other site 545693001583 Walker B; other site 545693001584 D-loop; other site 545693001585 H-loop/switch region; other site 545693001586 TOBE domain; Region: TOBE_2; cl01440 545693001587 Helix-turn-helix domains; Region: HTH; cl00088 545693001588 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001589 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001590 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001591 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001592 Protein of unknown function (DUF964); Region: DUF964; cl01483 545693001593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001594 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693001595 active site 545693001596 motif I; other site 545693001597 motif II; other site 545693001598 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693001599 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 545693001600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 545693001601 FeS/SAM binding site; other site 545693001602 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 545693001603 AMP-binding enzyme; Region: AMP-binding; cl15778 545693001604 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693001605 enoyl-CoA hydratase; Provisional; Region: PRK07659 545693001606 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693001607 substrate binding site [chemical binding]; other site 545693001608 oxyanion hole (OAH) forming residues; other site 545693001609 trimer interface [polypeptide binding]; other site 545693001610 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 545693001611 IHF dimer interface [polypeptide binding]; other site 545693001612 IHF - DNA interface [nucleotide binding]; other site 545693001613 YhzD-like protein; Region: YhzD; pfam14120 545693001614 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 545693001615 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 545693001616 Walker A/P-loop; other site 545693001617 ATP binding site [chemical binding]; other site 545693001618 Q-loop/lid; other site 545693001619 ABC transporter signature motif; other site 545693001620 Walker B; other site 545693001621 D-loop; other site 545693001622 H-loop/switch region; other site 545693001623 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 545693001624 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693001625 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693001626 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 545693001627 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 545693001628 generic binding surface II; other site 545693001629 generic binding surface I; other site 545693001630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693001631 Zn2+ binding site [ion binding]; other site 545693001632 Mg2+ binding site [ion binding]; other site 545693001633 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 545693001634 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 545693001635 PPIC-type PPIASE domain; Region: Rotamase; cl08278 545693001636 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 545693001637 protease production transcriptional regulator, frameshift 545693001638 YtxH-like protein; Region: YtxH; cl02079 545693001639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693001640 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 545693001641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693001642 catalytic residue [active] 545693001643 Helix-turn-helix domains; Region: HTH; cl00088 545693001644 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 545693001645 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693001646 OpgC protein; Region: OpgC_C; cl00792 545693001647 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693001648 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 545693001649 catalytic triad [active] 545693001650 catalytic triad [active] 545693001651 oxyanion hole [active] 545693001652 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 545693001653 HIT family signature motif; other site 545693001654 catalytic residue [active] 545693001655 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693001656 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693001657 Walker A/P-loop; other site 545693001658 ATP binding site [chemical binding]; other site 545693001659 Q-loop/lid; other site 545693001660 ABC transporter signature motif; other site 545693001661 Walker B; other site 545693001662 D-loop; other site 545693001663 H-loop/switch region; other site 545693001664 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 545693001665 EcsC protein family; Region: EcsC; pfam12787 545693001666 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693001667 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 545693001668 metal binding site [ion binding]; metal-binding site 545693001669 dimer interface [polypeptide binding]; other site 545693001670 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 545693001671 active site 545693001672 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693001673 Transglycosylase; Region: Transgly; cl07896 545693001674 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693001675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693001676 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 545693001677 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 545693001678 substrate binding site [chemical binding]; other site 545693001679 active site 545693001680 ferrochelatase; Provisional; Region: PRK12435 545693001681 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 545693001682 C-terminal domain interface [polypeptide binding]; other site 545693001683 active site 545693001684 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 545693001685 active site 545693001686 N-terminal domain interface [polypeptide binding]; other site 545693001687 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 545693001688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693001691 Helix-turn-helix domains; Region: HTH; cl00088 545693001692 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693001693 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693001694 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693001695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693001696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693001697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693001698 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 545693001699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693001700 dimerization interface [polypeptide binding]; other site 545693001701 Histidine kinase; Region: His_kinase; pfam06580 545693001702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693001703 ATP binding site [chemical binding]; other site 545693001704 Mg2+ binding site [ion binding]; other site 545693001705 G-X-G motif; other site 545693001706 Response regulator receiver domain; Region: Response_reg; pfam00072 545693001707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693001708 active site 545693001709 phosphorylation site [posttranslational modification] 545693001710 intermolecular recognition site; other site 545693001711 dimerization interface [polypeptide binding]; other site 545693001712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693001714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001715 YhfH-like protein; Region: YhfH; pfam14149 545693001716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693001717 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 545693001718 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 545693001719 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 545693001720 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 545693001721 AMP-binding enzyme; Region: AMP-binding; cl15778 545693001722 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693001723 enoyl-CoA hydratase; Provisional; Region: PRK07657 545693001724 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693001725 substrate binding site [chemical binding]; other site 545693001726 oxyanion hole (OAH) forming residues; other site 545693001727 trimer interface [polypeptide binding]; other site 545693001728 Peptidase family M48; Region: Peptidase_M48; cl12018 545693001729 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 545693001730 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 545693001731 tetramer interface [polypeptide binding]; other site 545693001732 active site 545693001733 Mg2+/Mn2+ binding site [ion binding]; other site 545693001734 IDEAL domain; Region: IDEAL; cl07452 545693001735 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 545693001736 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 545693001737 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693001738 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693001739 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693001740 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693001741 NAD(P) binding site [chemical binding]; other site 545693001742 homotetramer interface [polypeptide binding]; other site 545693001743 homodimer interface [polypeptide binding]; other site 545693001744 active site 545693001745 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 545693001746 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 545693001747 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 545693001748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693001749 Family description; Region: UvrD_C_2; cl15862 545693001750 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 545693001751 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 545693001752 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 545693001753 active site 545693001754 metal binding site [ion binding]; metal-binding site 545693001755 DNA binding site [nucleotide binding] 545693001756 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 545693001757 exonuclease SbcC; Region: sbcc; TIGR00618 545693001758 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 545693001759 Walker A/P-loop; other site 545693001760 ATP binding site [chemical binding]; other site 545693001761 Q-loop/lid; other site 545693001762 ABC transporter signature motif; other site 545693001763 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 545693001764 ABC transporter signature motif; other site 545693001765 Walker B; other site 545693001766 D-loop; other site 545693001767 H-loop/switch region; other site 545693001768 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 545693001769 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693001770 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 545693001771 Spore germination protein GerPC; Region: GerPC; pfam10737 545693001772 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 545693001773 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693001774 Predicted membrane protein [Function unknown]; Region: COG2311 545693001775 Protein of unknown function (DUF418); Region: DUF418; cl12135 545693001776 Protein of unknown function (DUF418); Region: DUF418; cl12135 545693001777 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 545693001778 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 545693001779 active site 545693001780 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 545693001781 dimer interface [polypeptide binding]; other site 545693001782 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 545693001783 Ligand Binding Site [chemical binding]; other site 545693001784 Molecular Tunnel; other site 545693001785 phytoene desaturase; Region: crtI_fam; TIGR02734 545693001786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001787 phytoene desaturase; Region: crtI_fam; TIGR02734 545693001788 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 545693001789 active site lid residues [active] 545693001790 substrate binding pocket [chemical binding]; other site 545693001791 catalytic residues [active] 545693001792 substrate-Mg2+ binding site; other site 545693001793 aspartate-rich region 1; other site 545693001794 aspartate-rich region 2; other site 545693001795 Nitrogen regulatory protein P-II; Region: P-II; cl00412 545693001796 Nitrogen regulatory protein P-II; Region: P-II; smart00938 545693001797 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 545693001798 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 545693001799 active site 545693001800 catalytic site [active] 545693001801 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 545693001802 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693001803 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693001804 DNA binding site [nucleotide binding] 545693001805 domain linker motif; other site 545693001806 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 545693001807 putative dimerization interface [polypeptide binding]; other site 545693001808 putative ligand binding site [chemical binding]; other site 545693001809 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 545693001810 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693001811 Glutamate binding site [chemical binding]; other site 545693001812 homodimer interface [polypeptide binding]; other site 545693001813 NAD binding site [chemical binding]; other site 545693001814 catalytic residues [active] 545693001815 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 545693001816 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001817 inhibitor-cofactor binding pocket; inhibition site 545693001818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001819 catalytic residue [active] 545693001820 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 545693001821 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 545693001822 putative metal binding site [ion binding]; other site 545693001823 putative dimer interface [polypeptide binding]; other site 545693001824 S-methylmethionine transporter; Provisional; Region: PRK11387 545693001825 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 545693001826 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693001827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001828 Walker A motif; other site 545693001829 ATP binding site [chemical binding]; other site 545693001830 Walker B motif; other site 545693001831 arginine finger; other site 545693001832 Helix-turn-helix domains; Region: HTH; cl00088 545693001833 short chain dehydrogenase; Provisional; Region: PRK06701 545693001834 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 545693001835 NAD binding site [chemical binding]; other site 545693001836 metal binding site [ion binding]; metal-binding site 545693001837 active site 545693001838 Protein of unknown function (DUF520); Region: DUF520; cl00723 545693001839 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 545693001840 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693001841 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693001842 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 545693001843 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693001844 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693001845 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001847 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693001848 active site 545693001849 motif I; other site 545693001850 motif II; other site 545693001851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693001852 Domain of unknown function DUF59; Region: DUF59; cl00941 545693001853 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693001854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693001855 ligand binding site [chemical binding]; other site 545693001856 flexible hinge region; other site 545693001857 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 545693001858 putative switch regulator; other site 545693001859 non-specific DNA interactions [nucleotide binding]; other site 545693001860 DNA binding site [nucleotide binding] 545693001861 sequence specific DNA binding site [nucleotide binding]; other site 545693001862 putative cAMP binding site [chemical binding]; other site 545693001863 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 545693001864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001865 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 545693001866 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 545693001867 heterotetramer interface [polypeptide binding]; other site 545693001868 active site pocket [active] 545693001869 cleavage site 545693001870 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 545693001871 nucleotide binding site [chemical binding]; other site 545693001872 N-acetyl-L-glutamate binding site [chemical binding]; other site 545693001873 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 545693001874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693001875 inhibitor-cofactor binding pocket; inhibition site 545693001876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693001877 catalytic residue [active] 545693001878 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 545693001879 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 545693001880 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 545693001881 catalytic site [active] 545693001882 subunit interface [polypeptide binding]; other site 545693001883 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 545693001884 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693001885 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001886 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 545693001887 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693001888 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693001889 ornithine carbamoyltransferase; Provisional; Region: PRK00779 545693001890 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 545693001891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001892 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 545693001893 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693001894 NAD(P) binding site [chemical binding]; other site 545693001895 putative active site [active] 545693001896 YjzC-like protein; Region: YjzC; pfam14168 545693001897 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 545693001898 Clp amino terminal domain; Region: Clp_N; pfam02861 545693001899 Clp amino terminal domain; Region: Clp_N; pfam02861 545693001900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001901 Walker A motif; other site 545693001902 ATP binding site [chemical binding]; other site 545693001903 Walker B motif; other site 545693001904 arginine finger; other site 545693001905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693001906 Walker A motif; other site 545693001907 ATP binding site [chemical binding]; other site 545693001908 Walker B motif; other site 545693001909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 545693001910 Cupin domain; Region: Cupin_2; cl09118 545693001911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693001913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693001914 galactokinase; Provisional; Region: PRK05322 545693001915 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 545693001916 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693001917 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693001918 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 545693001919 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 545693001920 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 545693001921 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693001923 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 545693001924 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693001925 extended (e) SDRs; Region: SDR_e; cd08946 545693001926 NAD(P) binding site [chemical binding]; other site 545693001927 active site 545693001928 substrate binding site [chemical binding]; other site 545693001929 ComZ; Region: ComZ; pfam10815 545693001930 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 545693001931 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693001932 dimer interface [polypeptide binding]; other site 545693001933 active site 545693001934 CoA binding pocket [chemical binding]; other site 545693001935 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 545693001936 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693001937 dimer interface [polypeptide binding]; other site 545693001938 active site 545693001939 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 545693001940 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693001941 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693001942 Walker A/P-loop; other site 545693001943 ATP binding site [chemical binding]; other site 545693001944 Q-loop/lid; other site 545693001945 ABC transporter signature motif; other site 545693001946 Walker B; other site 545693001947 D-loop; other site 545693001948 H-loop/switch region; other site 545693001949 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693001950 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693001951 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693001952 Walker A/P-loop; other site 545693001953 ATP binding site [chemical binding]; other site 545693001954 Q-loop/lid; other site 545693001955 ABC transporter signature motif; other site 545693001956 Walker B; other site 545693001957 D-loop; other site 545693001958 H-loop/switch region; other site 545693001959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693001960 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 545693001961 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 545693001962 peptide binding site [polypeptide binding]; other site 545693001963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001965 dimer interface [polypeptide binding]; other site 545693001966 conserved gate region; other site 545693001967 ABC-ATPase subunit interface; other site 545693001968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693001969 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693001970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001971 dimer interface [polypeptide binding]; other site 545693001972 conserved gate region; other site 545693001973 putative PBP binding loops; other site 545693001974 ABC-ATPase subunit interface; other site 545693001975 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 545693001976 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 545693001977 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 545693001978 active site 545693001979 HIGH motif; other site 545693001980 dimer interface [polypeptide binding]; other site 545693001981 KMSKS motif; other site 545693001982 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 545693001983 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 545693001984 peptide binding site [polypeptide binding]; other site 545693001985 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 545693001986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001987 dimer interface [polypeptide binding]; other site 545693001988 conserved gate region; other site 545693001989 putative PBP binding loops; other site 545693001990 ABC-ATPase subunit interface; other site 545693001991 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 545693001992 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693001994 dimer interface [polypeptide binding]; other site 545693001995 conserved gate region; other site 545693001996 putative PBP binding loops; other site 545693001997 ABC-ATPase subunit interface; other site 545693001998 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693001999 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693002000 Walker A/P-loop; other site 545693002001 ATP binding site [chemical binding]; other site 545693002002 Q-loop/lid; other site 545693002003 ABC transporter signature motif; other site 545693002004 Walker B; other site 545693002005 D-loop; other site 545693002006 H-loop/switch region; other site 545693002007 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002008 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693002009 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693002010 Walker A/P-loop; other site 545693002011 ATP binding site [chemical binding]; other site 545693002012 Q-loop/lid; other site 545693002013 ABC transporter signature motif; other site 545693002014 Walker B; other site 545693002015 D-loop; other site 545693002016 H-loop/switch region; other site 545693002017 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693002018 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693002019 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693002020 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 545693002021 Spore germination protein; Region: Spore_permease; cl15802 545693002022 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 545693002023 ArsC family; Region: ArsC; pfam03960 545693002024 putative catalytic residues [active] 545693002025 thiol/disulfide switch; other site 545693002026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002027 Helix-turn-helix domains; Region: HTH; cl00088 545693002028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693002029 dimerization interface [polypeptide binding]; other site 545693002030 Malonate transporter MadL subunit; Region: MadL; cl04273 545693002031 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 545693002032 Integral membrane protein TerC family; Region: TerC; cl10468 545693002033 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 545693002034 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 545693002035 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693002036 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693002037 putative active site [active] 545693002038 catalytic site [active] 545693002039 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693002040 putative active site [active] 545693002041 catalytic site [active] 545693002042 Competence protein CoiA-like family; Region: CoiA; cl11541 545693002043 oligoendopeptidase F; Region: pepF; TIGR00181 545693002044 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 545693002045 active site 545693002046 Zn binding site [ion binding]; other site 545693002047 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 545693002048 Thioredoxin; Region: Thioredoxin_5; pfam13743 545693002049 catalytic residues [active] 545693002050 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 545693002051 apolar tunnel; other site 545693002052 heme binding site [chemical binding]; other site 545693002053 dimerization interface [polypeptide binding]; other site 545693002054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 545693002055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 545693002056 catalytic residue [active] 545693002057 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 545693002058 putative active site [active] 545693002059 putative metal binding residues [ion binding]; other site 545693002060 signature motif; other site 545693002061 putative triphosphate binding site [ion binding]; other site 545693002062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 545693002063 synthetase active site [active] 545693002064 NTP binding site [chemical binding]; other site 545693002065 metal binding site [ion binding]; metal-binding site 545693002066 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 545693002067 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 545693002068 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 545693002069 active site 545693002070 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 545693002071 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693002072 active site 545693002073 metal binding site [ion binding]; metal-binding site 545693002074 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 545693002075 MgtE intracellular N domain; Region: MgtE_N; cl15244 545693002076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 545693002077 Divalent cation transporter; Region: MgtE; cl00786 545693002078 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 545693002079 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693002080 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002082 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693002083 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 545693002084 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 545693002085 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 545693002086 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 545693002087 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 545693002088 Peptidase family M48; Region: Peptidase_M48; cl12018 545693002089 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 545693002090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693002091 Family description; Region: UvrD_C_2; cl15862 545693002092 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693002093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002094 Coenzyme A binding pocket [chemical binding]; other site 545693002095 hypothetical protein; Provisional; Region: PRK13679 545693002096 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693002097 Putative esterase; Region: Esterase; pfam00756 545693002098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693002099 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 545693002100 tetramer interfaces [polypeptide binding]; other site 545693002101 binuclear metal-binding site [ion binding]; other site 545693002102 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693002103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002104 Coenzyme A binding pocket [chemical binding]; other site 545693002105 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002106 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002108 putative active site [active] 545693002109 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 545693002110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002111 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 545693002112 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 545693002113 N- and C-terminal domain interface [polypeptide binding]; other site 545693002114 putative active site [active] 545693002115 catalytic site [active] 545693002116 metal binding site [ion binding]; metal-binding site 545693002117 carbohydrate binding site [chemical binding]; other site 545693002118 ATP binding site [chemical binding]; other site 545693002119 Sodium:solute symporter family; Region: SSF; cl00456 545693002120 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693002121 GntP family permease; Region: GntP_permease; pfam02447 545693002122 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 545693002123 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693002124 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 545693002125 Helix-turn-helix domains; Region: HTH; cl00088 545693002126 N-acetyltransferase; Region: Acetyltransf_2; cl00949 545693002127 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 545693002128 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 545693002129 catalytic residues [active] 545693002130 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 545693002131 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693002132 ATP binding site [chemical binding]; other site 545693002133 Mg++ binding site [ion binding]; other site 545693002134 motif III; other site 545693002135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693002136 nucleotide binding region [chemical binding]; other site 545693002137 ATP-binding site [chemical binding]; other site 545693002138 DbpA RNA binding domain; Region: DbpA; pfam03880 545693002139 Class I aldolases; Region: Aldolase_Class_I; cd00945 545693002140 catalytic residue [active] 545693002141 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693002142 Heat induced stress protein YflT; Region: YflT; pfam11181 545693002143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 545693002144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693002145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002146 Helix-turn-helix domains; Region: HTH; cl00088 545693002147 WHG domain; Region: WHG; pfam13305 545693002148 Helix-turn-helix domains; Region: HTH; cl00088 545693002149 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693002150 Helix-turn-helix domains; Region: HTH; cl00088 545693002151 PRD domain; Region: PRD; cl15445 545693002152 PRD domain; Region: PRD; cl15445 545693002153 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693002154 active site 545693002155 P-loop; other site 545693002156 phosphorylation site [posttranslational modification] 545693002157 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693002158 active site 545693002159 phosphorylation site [posttranslational modification] 545693002160 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 545693002161 active site 545693002162 P-loop; other site 545693002163 phosphorylation site [posttranslational modification] 545693002164 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 545693002165 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693002166 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 545693002167 methionine cluster; other site 545693002168 active site 545693002169 phosphorylation site [posttranslational modification] 545693002170 metal binding site [ion binding]; metal-binding site 545693002171 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 545693002172 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 545693002173 NAD binding site [chemical binding]; other site 545693002174 sugar binding site [chemical binding]; other site 545693002175 divalent metal binding site [ion binding]; other site 545693002176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693002177 dimer interface [polypeptide binding]; other site 545693002178 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 545693002179 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693002180 GAF domain; Region: GAF; cl15785 545693002181 Histidine kinase; Region: His_kinase; pfam06580 545693002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 545693002183 two-component response regulator; Provisional; Region: PRK14084 545693002184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002185 active site 545693002186 phosphorylation site [posttranslational modification] 545693002187 intermolecular recognition site; other site 545693002188 dimerization interface [polypeptide binding]; other site 545693002189 LytTr DNA-binding domain; Region: LytTR; cl04498 545693002190 LrgA family; Region: LrgA; cl00608 545693002191 LrgB-like family; Region: LrgB; cl00596 545693002192 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 545693002193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693002194 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 545693002195 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693002196 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 545693002197 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 545693002198 [4Fe-4S] binding site [ion binding]; other site 545693002199 molybdopterin cofactor binding site; other site 545693002200 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 545693002201 molybdopterin cofactor binding site; other site 545693002202 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 545693002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002204 putative substrate translocation pore; other site 545693002205 spermidine synthase; Provisional; Region: PRK00811 545693002206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693002207 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 545693002208 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693002209 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 545693002210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693002211 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 545693002212 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 545693002213 tetramer interface [polypeptide binding]; other site 545693002214 active site 545693002215 Mg2+/Mn2+ binding site [ion binding]; other site 545693002216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693002217 active site 545693002218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002219 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 545693002220 PYR/PP interface [polypeptide binding]; other site 545693002221 dimer interface [polypeptide binding]; other site 545693002222 TPP binding site [chemical binding]; other site 545693002223 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 545693002224 TPP-binding site; other site 545693002225 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 545693002226 active site 545693002227 metal-binding site 545693002228 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 545693002229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693002230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693002231 catalytic residue [active] 545693002232 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693002233 nudix motif; other site 545693002234 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 545693002235 acetolactate synthase; Reviewed; Region: PRK08617 545693002236 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002237 PYR/PP interface [polypeptide binding]; other site 545693002238 dimer interface [polypeptide binding]; other site 545693002239 TPP binding site [chemical binding]; other site 545693002240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693002241 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 545693002242 TPP-binding site [chemical binding]; other site 545693002243 dimer interface [polypeptide binding]; other site 545693002244 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 545693002245 Helix-turn-helix domains; Region: HTH; cl00088 545693002246 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002248 putative substrate translocation pore; other site 545693002249 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 545693002250 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693002251 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 545693002252 Acyl transferase domain; Region: Acyl_transf_1; cl08282 545693002253 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 545693002254 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 545693002255 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 545693002256 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693002257 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693002258 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 545693002259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002260 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002261 active site 545693002262 phosphorylation site [posttranslational modification] 545693002263 intermolecular recognition site; other site 545693002264 dimerization interface [polypeptide binding]; other site 545693002265 YcbB domain; Region: YcbB; pfam08664 545693002266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693002267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002268 ATP binding site [chemical binding]; other site 545693002269 Mg2+ binding site [ion binding]; other site 545693002270 G-X-G motif; other site 545693002271 Glutaminase; Region: Glutaminase; cl00907 545693002272 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693002273 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 545693002274 Sodium:solute symporter family; Region: SSF; cl00456 545693002275 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693002276 Cupin domain; Region: Cupin_2; cl09118 545693002277 amino acid transporter; Region: 2A0306; TIGR00909 545693002278 Spore germination protein; Region: Spore_permease; cl15802 545693002279 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 545693002280 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 545693002281 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 545693002282 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 545693002283 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693002284 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 545693002285 iron-sulfur cluster [ion binding]; other site 545693002286 [2Fe-2S] cluster binding site [ion binding]; other site 545693002287 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 545693002288 hydrophobic ligand binding site; other site 545693002289 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 545693002290 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 545693002291 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 545693002292 Walker A/P-loop; other site 545693002293 ATP binding site [chemical binding]; other site 545693002294 Q-loop/lid; other site 545693002295 ABC transporter signature motif; other site 545693002296 Walker B; other site 545693002297 D-loop; other site 545693002298 H-loop/switch region; other site 545693002299 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 545693002300 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693002301 homodimer interface [polypeptide binding]; other site 545693002302 substrate-cofactor binding pocket; other site 545693002303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002304 catalytic residue [active] 545693002305 Yip1 domain; Region: Yip1; cl12048 545693002306 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 545693002307 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 545693002308 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693002309 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693002310 Walker A/P-loop; other site 545693002311 ATP binding site [chemical binding]; other site 545693002312 Q-loop/lid; other site 545693002313 ABC transporter signature motif; other site 545693002314 Walker B; other site 545693002315 D-loop; other site 545693002316 H-loop/switch region; other site 545693002317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693002318 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 545693002319 FtsX-like permease family; Region: FtsX; cl15850 545693002320 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 545693002321 active site 545693002322 catalytic residues [active] 545693002323 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 545693002324 dihydropteroate synthase; Region: DHPS; TIGR01496 545693002325 substrate binding pocket [chemical binding]; other site 545693002326 dimer interface [polypeptide binding]; other site 545693002327 inhibitor binding site; inhibition site 545693002328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002330 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 545693002331 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693002332 nucleoside transporter; Region: nupC; TIGR00804 545693002333 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693002334 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693002335 S-methylmethionine transporter; Provisional; Region: PRK11387 545693002336 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693002337 AAA domain; Region: AAA_26; pfam13500 545693002338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693002339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693002340 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 545693002341 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002342 inhibitor-cofactor binding pocket; inhibition site 545693002343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002344 catalytic residue [active] 545693002345 Integral membrane protein TerC family; Region: TerC; cl10468 545693002346 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693002347 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 545693002348 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 545693002349 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693002350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693002351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002352 ATP binding site [chemical binding]; other site 545693002353 Mg2+ binding site [ion binding]; other site 545693002354 G-X-G motif; other site 545693002355 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693002356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002357 active site 545693002358 phosphorylation site [posttranslational modification] 545693002359 intermolecular recognition site; other site 545693002360 dimerization interface [polypeptide binding]; other site 545693002361 Helix-turn-helix domains; Region: HTH; cl00088 545693002362 Sugar transport protein; Region: Sugar_transport; pfam06800 545693002363 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693002364 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693002365 NAD binding site [chemical binding]; other site 545693002366 homodimer interface [polypeptide binding]; other site 545693002367 active site 545693002368 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 545693002369 ApbE family; Region: ApbE; cl00643 545693002370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693002371 non-specific DNA binding site [nucleotide binding]; other site 545693002372 salt bridge; other site 545693002373 sequence-specific DNA binding site [nucleotide binding]; other site 545693002374 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693002375 TrbC/VIRB2 family; Region: TrbC; cl01583 545693002376 Sulfatase; Region: Sulfatase; cl10460 545693002377 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693002378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002379 Coenzyme A binding pocket [chemical binding]; other site 545693002380 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693002381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693002382 DNA-binding site [nucleotide binding]; DNA binding site 545693002383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693002384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002385 homodimer interface [polypeptide binding]; other site 545693002386 catalytic residue [active] 545693002387 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 545693002388 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 545693002389 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693002390 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693002391 Citrate transporter; Region: CitMHS; pfam03600 545693002392 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693002393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693002394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002395 ATP binding site [chemical binding]; other site 545693002396 Mg2+ binding site [ion binding]; other site 545693002397 G-X-G motif; other site 545693002398 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 545693002399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002400 active site 545693002401 phosphorylation site [posttranslational modification] 545693002402 intermolecular recognition site; other site 545693002403 dimerization interface [polypeptide binding]; other site 545693002404 Transcriptional regulator; Region: CitT; pfam12431 545693002405 Helix-turn-helix domains; Region: HTH; cl00088 545693002406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 545693002407 NMT1-like family; Region: NMT1_2; cl15260 545693002408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002409 Helix-turn-helix domains; Region: HTH; cl00088 545693002410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693002411 dimerization interface [polypeptide binding]; other site 545693002412 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 545693002413 Putative ammonia monooxygenase; Region: AmoA; pfam05145 545693002414 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 545693002415 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693002416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693002417 S-adenosylmethionine binding site [chemical binding]; other site 545693002418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002420 dimer interface [polypeptide binding]; other site 545693002421 conserved gate region; other site 545693002422 putative PBP binding loops; other site 545693002423 ABC-ATPase subunit interface; other site 545693002424 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 545693002425 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 545693002426 Walker A/P-loop; other site 545693002427 ATP binding site [chemical binding]; other site 545693002428 Q-loop/lid; other site 545693002429 ABC transporter signature motif; other site 545693002430 Walker B; other site 545693002431 D-loop; other site 545693002432 H-loop/switch region; other site 545693002433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 545693002434 NMT1-like family; Region: NMT1_2; cl15260 545693002435 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 545693002436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002437 Helix-turn-helix domains; Region: HTH; cl00088 545693002438 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 545693002439 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693002440 tetramerization interface [polypeptide binding]; other site 545693002441 NAD(P) binding site [chemical binding]; other site 545693002442 catalytic residues [active] 545693002443 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 545693002444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002445 inhibitor-cofactor binding pocket; inhibition site 545693002446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002447 catalytic residue [active] 545693002448 Arginase family; Region: Arginase; cl00306 545693002449 Spore germination protein; Region: Spore_permease; cl15802 545693002450 amino acid transporter; Region: 2A0306; TIGR00909 545693002451 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 545693002452 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693002453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693002454 motif II; other site 545693002455 NMT1-like family; Region: NMT1_2; cl15260 545693002456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002457 conserved gate region; other site 545693002458 ABC-ATPase subunit interface; other site 545693002459 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 545693002460 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 545693002461 Walker A/P-loop; other site 545693002462 ATP binding site [chemical binding]; other site 545693002463 Q-loop/lid; other site 545693002464 ABC transporter signature motif; other site 545693002465 Walker B; other site 545693002466 D-loop; other site 545693002467 H-loop/switch region; other site 545693002468 NIL domain; Region: NIL; cl09633 545693002469 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 545693002470 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693002471 active site 545693002472 non-prolyl cis peptide bond; other site 545693002473 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 545693002474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693002475 active site 545693002476 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 545693002477 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693002478 active site 545693002479 dimer interface [polypeptide binding]; other site 545693002480 non-prolyl cis peptide bond; other site 545693002481 insertion regions; other site 545693002482 V-type ATP synthase subunit H; Validated; Region: PRK08404 545693002483 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 545693002484 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 545693002485 Flavin binding site [chemical binding]; other site 545693002486 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 545693002487 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 545693002488 siderophore binding site; other site 545693002489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693002490 ABC-ATPase subunit interface; other site 545693002491 dimer interface [polypeptide binding]; other site 545693002492 putative PBP binding regions; other site 545693002493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693002494 ABC-ATPase subunit interface; other site 545693002495 dimer interface [polypeptide binding]; other site 545693002496 putative PBP binding regions; other site 545693002497 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693002498 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693002499 endonuclease VIII; Provisional; Region: PRK10445 545693002500 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 545693002501 DNA binding site [nucleotide binding] 545693002502 catalytic residue [active] 545693002503 putative catalytic residues [active] 545693002504 H2TH interface [polypeptide binding]; other site 545693002505 intercalation triad [nucleotide binding]; other site 545693002506 substrate specificity determining residue; other site 545693002507 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 545693002508 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 545693002509 dimer interaction site [polypeptide binding]; other site 545693002510 substrate-binding tunnel; other site 545693002511 active site 545693002512 catalytic site [active] 545693002513 substrate binding site [chemical binding]; other site 545693002514 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 545693002515 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002516 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002517 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002518 putative active site [active] 545693002519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693002520 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 545693002521 active site turn [active] 545693002522 phosphorylation site [posttranslational modification] 545693002523 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693002524 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 545693002525 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 545693002526 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 545693002527 metal binding site [ion binding]; metal-binding site 545693002528 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 545693002529 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693002530 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 545693002531 Walker A/P-loop; other site 545693002532 ATP binding site [chemical binding]; other site 545693002533 Q-loop/lid; other site 545693002534 ABC transporter signature motif; other site 545693002535 Walker B; other site 545693002536 D-loop; other site 545693002537 H-loop/switch region; other site 545693002538 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693002539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002540 dimer interface [polypeptide binding]; other site 545693002541 conserved gate region; other site 545693002542 putative PBP binding loops; other site 545693002543 ABC-ATPase subunit interface; other site 545693002544 NMT1/THI5 like; Region: NMT1; pfam09084 545693002545 NMT1-like family; Region: NMT1_2; cl15260 545693002546 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 545693002547 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 545693002548 tetramer interface [polypeptide binding]; other site 545693002549 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 545693002550 active site 545693002551 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693002552 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 545693002553 active site 545693002554 dimer interface [polypeptide binding]; other site 545693002555 magnesium binding site [ion binding]; other site 545693002556 Helix-turn-helix domains; Region: HTH; cl00088 545693002557 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693002558 Virus attachment protein p12 family; Region: P12; pfam12669 545693002559 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 545693002560 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 545693002561 G1 box; other site 545693002562 GTP/Mg2+ binding site [chemical binding]; other site 545693002563 Switch I region; other site 545693002564 G2 box; other site 545693002565 G3 box; other site 545693002566 Switch II region; other site 545693002567 G4 box; other site 545693002568 G5 box; other site 545693002569 Nucleoside recognition; Region: Gate; cl00486 545693002570 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 545693002571 Nucleoside recognition; Region: Gate; cl00486 545693002572 FeoA domain; Region: FeoA; cl00838 545693002573 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 545693002574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693002575 Coenzyme A binding pocket [chemical binding]; other site 545693002576 Predicted membrane protein [Function unknown]; Region: COG1511 545693002577 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693002578 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 545693002579 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 545693002580 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 545693002581 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693002582 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693002583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002584 TEA/ATTS domain family; Region: TEA; cl02603 545693002585 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 545693002586 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 545693002587 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 545693002588 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 545693002589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693002590 dimerization interface [polypeptide binding]; other site 545693002591 putative DNA binding site [nucleotide binding]; other site 545693002592 putative Zn2+ binding site [ion binding]; other site 545693002593 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 545693002594 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693002595 putative NAD(P) binding site [chemical binding]; other site 545693002596 substrate binding site [chemical binding]; other site 545693002597 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693002598 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693002599 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 545693002600 Walker A/P-loop; other site 545693002601 ATP binding site [chemical binding]; other site 545693002602 Q-loop/lid; other site 545693002603 ABC transporter signature motif; other site 545693002604 Walker B; other site 545693002605 D-loop; other site 545693002606 H-loop/switch region; other site 545693002607 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693002608 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693002609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693002610 Walker A/P-loop; other site 545693002611 ATP binding site [chemical binding]; other site 545693002612 Q-loop/lid; other site 545693002613 ABC transporter signature motif; other site 545693002614 Walker B; other site 545693002615 D-loop; other site 545693002616 H-loop/switch region; other site 545693002617 Sodium:solute symporter family; Region: SSF; cl00456 545693002618 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 545693002619 Protein of unknown function, DUF485; Region: DUF485; cl01231 545693002620 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693002621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693002622 Helix-turn-helix domains; Region: HTH; cl00088 545693002623 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693002624 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693002625 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693002626 active site 545693002627 catalytic tetrad [active] 545693002628 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 545693002629 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 545693002630 putative NAD(P) binding site [chemical binding]; other site 545693002631 active site 545693002632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693002633 Helix-turn-helix domains; Region: HTH; cl00088 545693002634 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693002635 carboxyltransferase (CT) interaction site; other site 545693002636 biotinylation site [posttranslational modification]; other site 545693002637 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 545693002638 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693002639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002641 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693002642 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693002643 Helix-turn-helix domains; Region: HTH; cl00088 545693002644 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693002645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693002646 DNA binding site [nucleotide binding] 545693002647 domain linker motif; other site 545693002648 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 545693002649 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693002650 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 545693002651 substrate binding site [chemical binding]; other site 545693002652 dimer interface [polypeptide binding]; other site 545693002653 ATP binding site [chemical binding]; other site 545693002654 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 545693002655 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 545693002656 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 545693002657 Walker A/P-loop; other site 545693002658 ATP binding site [chemical binding]; other site 545693002659 Q-loop/lid; other site 545693002660 ABC transporter signature motif; other site 545693002661 Walker B; other site 545693002662 D-loop; other site 545693002663 H-loop/switch region; other site 545693002664 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 545693002665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 545693002666 TM-ABC transporter signature motif; other site 545693002667 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 545693002668 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693002669 ligand binding site [chemical binding]; other site 545693002670 dimerization interface [polypeptide binding]; other site 545693002671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 545693002672 3D domain; Region: 3D; cl01439 545693002673 Flavin Reductases; Region: FlaRed; cl00801 545693002674 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693002675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693002676 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 545693002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002678 dimer interface [polypeptide binding]; other site 545693002679 putative PBP binding loops; other site 545693002680 ABC-ATPase subunit interface; other site 545693002681 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693002683 dimer interface [polypeptide binding]; other site 545693002684 conserved gate region; other site 545693002685 putative PBP binding loops; other site 545693002686 ABC-ATPase subunit interface; other site 545693002687 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693002688 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693002689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002690 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002691 active site 545693002692 phosphorylation site [posttranslational modification] 545693002693 intermolecular recognition site; other site 545693002694 dimerization interface [polypeptide binding]; other site 545693002695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693002696 metal binding site [ion binding]; metal-binding site 545693002697 active site 545693002698 I-site; other site 545693002699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002700 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002701 active site 545693002702 phosphorylation site [posttranslational modification] 545693002703 intermolecular recognition site; other site 545693002704 dimerization interface [polypeptide binding]; other site 545693002705 HEAT repeats; Region: HEAT_2; pfam13646 545693002706 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 545693002707 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 545693002708 DXD motif; other site 545693002709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693002710 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002712 active site 545693002713 phosphorylation site [posttranslational modification] 545693002714 intermolecular recognition site; other site 545693002715 dimerization interface [polypeptide binding]; other site 545693002716 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 545693002717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693002718 GAF domain; Region: GAF_2; pfam13185 545693002719 GAF domain; Region: GAF; cl15785 545693002720 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693002722 dimer interface [polypeptide binding]; other site 545693002723 phosphorylation site [posttranslational modification] 545693002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002725 ATP binding site [chemical binding]; other site 545693002726 Mg2+ binding site [ion binding]; other site 545693002727 G-X-G motif; other site 545693002728 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002730 active site 545693002731 phosphorylation site [posttranslational modification] 545693002732 intermolecular recognition site; other site 545693002733 dimerization interface [polypeptide binding]; other site 545693002734 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 545693002735 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693002736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693002737 catalytic core [active] 545693002738 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 545693002739 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693002740 inhibitor-cofactor binding pocket; inhibition site 545693002741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693002742 catalytic residue [active] 545693002743 YKOF-related Family; Region: Ykof; pfam07615 545693002744 YKOF-related Family; Region: Ykof; pfam07615 545693002745 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 545693002746 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 545693002747 active site 545693002748 putative substrate binding pocket [chemical binding]; other site 545693002749 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693002750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693002751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693002752 DNA binding site [nucleotide binding] 545693002753 domain linker motif; other site 545693002754 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 545693002755 putative dimerization interface [polypeptide binding]; other site 545693002756 putative ligand binding site [chemical binding]; other site 545693002757 shikimate kinase; Reviewed; Region: aroK; PRK00131 545693002758 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 545693002759 ADP binding site [chemical binding]; other site 545693002760 magnesium binding site [ion binding]; other site 545693002761 putative shikimate binding site; other site 545693002762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693002763 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693002764 NAD(P) binding site [chemical binding]; other site 545693002765 catalytic residues [active] 545693002766 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 545693002767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693002768 PYR/PP interface [polypeptide binding]; other site 545693002769 dimer interface [polypeptide binding]; other site 545693002770 TPP binding site [chemical binding]; other site 545693002771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693002772 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693002773 TPP-binding site [chemical binding]; other site 545693002774 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 545693002775 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 545693002776 active site 545693002777 catalytic residue [active] 545693002778 dimer interface [polypeptide binding]; other site 545693002779 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 545693002780 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 545693002781 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693002782 active site turn [active] 545693002783 phosphorylation site [posttranslational modification] 545693002784 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693002785 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 545693002786 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 545693002787 Ca binding site [ion binding]; other site 545693002788 active site 545693002789 catalytic site [active] 545693002790 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 545693002791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693002792 DNA-binding site [nucleotide binding]; DNA binding site 545693002793 UTRA domain; Region: UTRA; cl01230 545693002794 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 545693002795 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 545693002796 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 545693002797 LamB/YcsF family; Region: LamB_YcsF; cl00664 545693002798 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 545693002799 Haemolysin-III related; Region: HlyIII; cl03831 545693002800 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 545693002801 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 545693002802 putative FMN binding site [chemical binding]; other site 545693002803 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693002804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002805 Helix-turn-helix domains; Region: HTH; cl00088 545693002806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693002807 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 545693002808 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693002809 putative NAD(P) binding site [chemical binding]; other site 545693002810 substrate binding site [chemical binding]; other site 545693002811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693002812 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 545693002813 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 545693002814 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 545693002815 shikimate binding site; other site 545693002816 NAD(P) binding site [chemical binding]; other site 545693002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693002818 D-galactonate transporter; Region: 2A0114; TIGR00893 545693002819 putative substrate translocation pore; other site 545693002820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 545693002821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 545693002822 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 545693002823 active site 545693002824 catalytic residues [active] 545693002825 metal binding site [ion binding]; metal-binding site 545693002826 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693002827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693002828 NAD(P) binding site [chemical binding]; other site 545693002829 catalytic residues [active] 545693002830 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693002831 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 545693002832 cytosine deaminase; Provisional; Region: PRK05985 545693002833 active site 545693002834 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693002835 DNA-binding site [nucleotide binding]; DNA binding site 545693002836 RNA-binding motif; other site 545693002837 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693002838 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693002839 NAD binding site [chemical binding]; other site 545693002840 substrate binding site [chemical binding]; other site 545693002841 putative active site [active] 545693002842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693002843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693002844 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 545693002845 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 545693002846 dimer interface [polypeptide binding]; other site 545693002847 decamer (pentamer of dimers) interface [polypeptide binding]; other site 545693002848 catalytic triad [active] 545693002849 peroxidatic and resolving cysteines [active] 545693002850 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693002851 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693002852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693002853 YvrJ protein family; Region: YvrJ; pfam12841 545693002854 hypothetical protein; Provisional; Region: PRK14082 545693002855 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693002856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693002857 metal binding site [ion binding]; metal-binding site 545693002858 active site 545693002859 I-site; other site 545693002860 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 545693002861 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693002862 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693002863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693002864 Helix-turn-helix domains; Region: HTH; cl00088 545693002865 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 545693002866 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693002867 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 545693002868 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 545693002869 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 545693002870 putative active site [active] 545693002871 putative metal binding site [ion binding]; other site 545693002872 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693002873 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 545693002874 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693002875 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 545693002876 Staygreen protein; Region: Staygreen; pfam12638 545693002877 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 545693002878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693002879 active site 545693002880 motif I; other site 545693002881 motif II; other site 545693002882 CsbD-like; Region: CsbD; cl15799 545693002883 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 545693002884 nudix motif; other site 545693002885 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 545693002886 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693002887 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693002888 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693002889 putative active site [active] 545693002890 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 545693002891 active site 545693002892 P-loop; other site 545693002893 phosphorylation site [posttranslational modification] 545693002894 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693002895 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 545693002896 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 545693002897 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 545693002898 NAD binding site [chemical binding]; other site 545693002899 sugar binding site [chemical binding]; other site 545693002900 divalent metal binding site [ion binding]; other site 545693002901 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693002902 dimer interface [polypeptide binding]; other site 545693002903 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 545693002904 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 545693002905 methionine cluster; other site 545693002906 active site 545693002907 phosphorylation site [posttranslational modification] 545693002908 metal binding site [ion binding]; metal-binding site 545693002909 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 545693002910 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 545693002911 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 545693002912 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 545693002913 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 545693002914 putative active site [active] 545693002915 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693002916 Helix-turn-helix domains; Region: HTH; cl00088 545693002917 PRD domain; Region: PRD; cl15445 545693002918 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693002919 active site 545693002920 P-loop; other site 545693002921 phosphorylation site [posttranslational modification] 545693002922 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693002923 active site 545693002924 phosphorylation site [posttranslational modification] 545693002925 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 545693002926 active site 545693002927 P-loop; other site 545693002928 phosphorylation site [posttranslational modification] 545693002929 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 545693002930 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693002931 active site 545693002932 catalytic triad [active] 545693002933 dimer interface [polypeptide binding]; other site 545693002934 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 545693002935 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693002936 active site 545693002937 dimer interface [polypeptide binding]; other site 545693002938 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693002939 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693002940 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693002941 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693002942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693002943 S-adenosylmethionine binding site [chemical binding]; other site 545693002944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693002945 Helix-turn-helix domains; Region: HTH; cl00088 545693002946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693002947 dimerization interface [polypeptide binding]; other site 545693002948 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 545693002949 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 545693002950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693002951 active site 545693002952 catalytic tetrad [active] 545693002953 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 545693002954 Amidase; Region: Amidase; cl11426 545693002955 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 545693002956 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693002957 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 545693002958 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 545693002959 NAD binding site [chemical binding]; other site 545693002960 homodimer interface [polypeptide binding]; other site 545693002961 active site 545693002962 substrate binding site [chemical binding]; other site 545693002963 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 545693002964 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693002965 Predicted membrane protein [Function unknown]; Region: COG3212 545693002966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693002967 PAS domain S-box; Region: sensory_box; TIGR00229 545693002968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693002969 PAS domain S-box; Region: sensory_box; TIGR00229 545693002970 PAS domain; Region: PAS_9; pfam13426 545693002971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693002972 putative active site [active] 545693002973 heme pocket [chemical binding]; other site 545693002974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693002975 metal binding site [ion binding]; metal-binding site 545693002976 active site 545693002977 I-site; other site 545693002978 Helix-turn-helix domains; Region: HTH; cl00088 545693002979 Sugar transport protein; Region: Sugar_transport; pfam06800 545693002980 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 545693002981 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693002982 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693002983 NAD binding site [chemical binding]; other site 545693002984 homodimer interface [polypeptide binding]; other site 545693002985 active site 545693002986 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 545693002987 Membrane transport protein; Region: Mem_trans; cl09117 545693002988 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693002989 Sodium:solute symporter family; Region: SSF; cl00456 545693002990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693002991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693002992 ATP binding site [chemical binding]; other site 545693002993 Mg2+ binding site [ion binding]; other site 545693002994 G-X-G motif; other site 545693002995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693002996 Response regulator receiver domain; Region: Response_reg; pfam00072 545693002997 active site 545693002998 phosphorylation site [posttranslational modification] 545693002999 intermolecular recognition site; other site 545693003000 dimerization interface [polypeptide binding]; other site 545693003001 YcbB domain; Region: YcbB; pfam08664 545693003002 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693003003 NlpC/P60 family; Region: NLPC_P60; cl11438 545693003004 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693003005 active site 545693003006 metal binding site [ion binding]; metal-binding site 545693003007 Stage II sporulation protein; Region: SpoIID; pfam08486 545693003008 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 545693003009 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 545693003010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693003011 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693003012 active site 545693003013 catalytic tetrad [active] 545693003014 IDEAL domain; Region: IDEAL; cl07452 545693003015 arsenical pump membrane protein; Provisional; Region: PRK15445 545693003016 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693003017 transmembrane helices; other site 545693003018 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 545693003019 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 545693003020 active site 545693003021 octamer interface [polypeptide binding]; other site 545693003022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003023 Coenzyme A binding pocket [chemical binding]; other site 545693003024 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693003025 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693003026 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693003027 putative active site [active] 545693003028 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693003029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003030 Walker A motif; other site 545693003031 ATP binding site [chemical binding]; other site 545693003032 Walker B motif; other site 545693003033 arginine finger; other site 545693003034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693003035 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 545693003036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693003037 inhibitor-cofactor binding pocket; inhibition site 545693003038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003039 catalytic residue [active] 545693003040 Sodium:solute symporter family; Region: SSF; cl00456 545693003041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693003042 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693003043 putative substrate translocation pore; other site 545693003044 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693003045 Protein export membrane protein; Region: SecD_SecF; cl14618 545693003046 Protein export membrane protein; Region: SecD_SecF; cl14618 545693003047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693003048 dimerization interface [polypeptide binding]; other site 545693003049 putative DNA binding site [nucleotide binding]; other site 545693003050 putative Zn2+ binding site [ion binding]; other site 545693003051 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 545693003052 SdpI/YhfL protein family; Region: SdpI; pfam13630 545693003053 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693003054 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693003055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693003056 dimerization interface [polypeptide binding]; other site 545693003057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693003058 metal binding site [ion binding]; metal-binding site 545693003059 active site 545693003060 I-site; other site 545693003061 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003062 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 545693003063 GTP cyclohydrolase I; Provisional; Region: PLN03044 545693003064 active site 545693003065 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 545693003066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003068 PAS domain; Region: PAS_9; pfam13426 545693003069 PAS fold; Region: PAS_3; pfam08447 545693003070 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 545693003071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003072 PAS fold; Region: PAS_3; pfam08447 545693003073 putative active site [active] 545693003074 heme pocket [chemical binding]; other site 545693003075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693003076 metal binding site [ion binding]; metal-binding site 545693003077 active site 545693003078 I-site; other site 545693003079 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003080 amino acid transporter; Region: 2A0306; TIGR00909 545693003081 Spore germination protein; Region: Spore_permease; cl15802 545693003082 N-carbamolyputrescine amidase; Region: PLN02747 545693003083 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 545693003084 putative active site; other site 545693003085 catalytic triad [active] 545693003086 putative dimer interface [polypeptide binding]; other site 545693003087 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 545693003088 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 545693003089 flagellin; Provisional; Region: PRK12804 545693003090 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 545693003091 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 545693003092 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 545693003093 putative substrate binding pocket [chemical binding]; other site 545693003094 AC domain interface; other site 545693003095 catalytic triad [active] 545693003096 AB domain interface; other site 545693003097 interchain disulfide; other site 545693003098 Protein of unknown function (DUF979); Region: DUF979; cl01572 545693003099 Protein of unknown function (DUF969); Region: DUF969; cl01573 545693003100 Predicted membrane protein [Function unknown]; Region: COG4640 545693003101 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 545693003102 HPP family; Region: HPP; pfam04982 545693003103 histidinol-phosphatase; Provisional; Region: PRK05588 545693003104 Anti-repressor SinI; Region: SinI; pfam08671 545693003105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693003106 non-specific DNA binding site [nucleotide binding]; other site 545693003107 salt bridge; other site 545693003108 sequence-specific DNA binding site [nucleotide binding]; other site 545693003109 Anti-repressor SinI; Region: SinI; pfam08671 545693003110 OpgC protein; Region: OpgC_C; cl00792 545693003111 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 545693003112 Chain length determinant protein; Region: Wzz; cl15801 545693003113 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 545693003114 Bacterial sugar transferase; Region: Bac_transf; cl00939 545693003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003116 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 545693003117 NAD(P) binding site [chemical binding]; other site 545693003118 active site 545693003119 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 545693003120 MatE; Region: MatE; cl10513 545693003121 O-Antigen ligase; Region: Wzy_C; cl04850 545693003122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003123 active site 545693003124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003125 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693003126 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 545693003127 Stage II sporulation protein; Region: SpoIID; pfam08486 545693003128 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 545693003129 VanZ like family; Region: VanZ; cl01971 545693003130 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693003132 active site 545693003133 tetramer interface; other site 545693003134 Bacterial sugar transferase; Region: Bac_transf; cl00939 545693003135 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 545693003136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003137 NAD(P) binding site [chemical binding]; other site 545693003138 LDH/MDH dimer interface [polypeptide binding]; other site 545693003139 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693003140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003141 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 545693003142 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693003143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003144 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693003145 active site 545693003146 trimer interface [polypeptide binding]; other site 545693003147 CoA binding site [chemical binding]; other site 545693003148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003149 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 545693003150 putative ADP-binding pocket [chemical binding]; other site 545693003151 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693003152 trimer interface [polypeptide binding]; other site 545693003153 active site 545693003154 substrate binding site [chemical binding]; other site 545693003155 CoA binding site [chemical binding]; other site 545693003156 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 545693003157 MatE; Region: MatE; cl10513 545693003158 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 545693003159 putative metal binding site [ion binding]; other site 545693003160 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 545693003161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693003162 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 545693003163 active site 545693003164 Cupin domain; Region: Cupin_2; cl09118 545693003165 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 545693003166 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 545693003167 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 545693003168 Chain length determinant protein; Region: Wzz; cl15801 545693003169 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 545693003170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693003171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693003172 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693003173 active site 545693003174 tetramer interface; other site 545693003175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693003176 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 545693003177 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693003178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003179 active site 545693003180 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 545693003181 putative glycosyl transferase; Provisional; Region: PRK10073 545693003182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693003183 putative glycosyl transferase; Provisional; Region: PRK10073 545693003184 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 545693003185 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693003186 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 545693003187 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 545693003188 Walker A/P-loop; other site 545693003189 ATP binding site [chemical binding]; other site 545693003190 Q-loop/lid; other site 545693003191 ABC transporter signature motif; other site 545693003192 Walker B; other site 545693003193 D-loop; other site 545693003194 H-loop/switch region; other site 545693003195 Bacterial SH3 domain; Region: SH3_3; cl02551 545693003196 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693003197 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 545693003198 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003199 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 545693003200 pyruvate oxidase; Provisional; Region: PRK08611 545693003201 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 545693003202 PYR/PP interface [polypeptide binding]; other site 545693003203 dimer interface [polypeptide binding]; other site 545693003204 tetramer interface [polypeptide binding]; other site 545693003205 TPP binding site [chemical binding]; other site 545693003206 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693003207 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 545693003208 TPP-binding site [chemical binding]; other site 545693003209 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 545693003210 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 545693003211 active site 545693003212 FMN binding site [chemical binding]; other site 545693003213 substrate binding site [chemical binding]; other site 545693003214 3Fe-4S cluster binding site [ion binding]; other site 545693003215 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693003216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003217 DNA-binding site [nucleotide binding]; DNA binding site 545693003218 FCD domain; Region: FCD; cl11656 545693003219 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 545693003220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003221 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 545693003222 GntP family permease; Region: GntP_permease; pfam02447 545693003223 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693003224 ComK protein; Region: ComK; cl11560 545693003225 RNA polymerase factor sigma-70; Validated; Region: PRK06759 545693003226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693003227 Helix-turn-helix domains; Region: HTH; cl00088 545693003228 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 545693003229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003230 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 545693003231 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 545693003232 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693003233 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 545693003234 [2Fe-2S] cluster binding site [ion binding]; other site 545693003235 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693003236 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693003237 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 545693003238 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693003239 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 545693003240 putative substrate binding site [chemical binding]; other site 545693003241 putative ATP binding site [chemical binding]; other site 545693003242 Sugar transport protein; Region: Sugar_transport; pfam06800 545693003243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693003244 active site 545693003245 metal binding site [ion binding]; metal-binding site 545693003246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693003247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693003248 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 545693003249 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 545693003250 GIY-YIG motif/motif A; other site 545693003251 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 545693003252 MatE; Region: MatE; cl10513 545693003253 MatE; Region: MatE; cl10513 545693003254 Cupin domain; Region: Cupin_2; cl09118 545693003255 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693003256 PilZ domain; Region: PilZ; cl01260 545693003257 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693003258 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 545693003259 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 545693003260 active site 545693003261 catalytic triad [active] 545693003262 adenylate kinase; Provisional; Region: PRK13808 545693003263 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 545693003264 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003266 Coenzyme A binding pocket [chemical binding]; other site 545693003267 hypothetical protein; Provisional; Region: PRK02947 545693003268 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693003269 putative active site [active] 545693003270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693003271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003272 DNA-binding site [nucleotide binding]; DNA binding site 545693003273 UTRA domain; Region: UTRA; cl01230 545693003274 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 545693003275 active site 545693003276 trimer interface [polypeptide binding]; other site 545693003277 allosteric site; other site 545693003278 active site lid [active] 545693003279 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693003280 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 545693003281 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 545693003282 active site 545693003283 dimer interface [polypeptide binding]; other site 545693003284 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 545693003285 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693003286 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693003287 active site turn [active] 545693003288 phosphorylation site [posttranslational modification] 545693003289 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 545693003290 HPr interaction site; other site 545693003291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693003292 active site 545693003293 phosphorylation site [posttranslational modification] 545693003294 Protein of unknown function (DUF554); Region: DUF554; cl00784 545693003295 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 545693003296 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 545693003297 dimer interface [polypeptide binding]; other site 545693003298 PYR/PP interface [polypeptide binding]; other site 545693003299 TPP binding site [chemical binding]; other site 545693003300 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693003301 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 545693003302 TPP-binding site [chemical binding]; other site 545693003303 dimer interface [polypeptide binding]; other site 545693003304 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693003305 Helix-turn-helix domains; Region: HTH; cl00088 545693003306 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693003307 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693003308 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 545693003309 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693003310 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693003311 Walker A/P-loop; other site 545693003312 ATP binding site [chemical binding]; other site 545693003313 Q-loop/lid; other site 545693003314 ABC transporter signature motif; other site 545693003315 Walker B; other site 545693003316 D-loop; other site 545693003317 H-loop/switch region; other site 545693003318 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693003319 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693003320 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693003321 Transporter associated domain; Region: CorC_HlyC; cl08393 545693003322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693003323 DNA binding residues [nucleotide binding] 545693003324 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 545693003325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693003326 putative metal binding site [ion binding]; other site 545693003327 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 545693003328 putative active site pocket [active] 545693003329 dimerization interface [polypeptide binding]; other site 545693003330 putative catalytic residue [active] 545693003331 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 545693003332 putative active site pocket [active] 545693003333 dimerization interface [polypeptide binding]; other site 545693003334 putative catalytic residue [active] 545693003335 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 545693003336 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 545693003337 active site 545693003338 catalytic residues [active] 545693003339 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 545693003340 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693003341 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 545693003342 Catalytic site [active] 545693003343 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693003344 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 545693003345 YmaF family; Region: YmaF; pfam12788 545693003346 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693003347 Protein of unknown function DUF45; Region: DUF45; cl00636 545693003348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003349 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693003350 Coenzyme A binding pocket [chemical binding]; other site 545693003351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693003352 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 545693003353 metal binding site [ion binding]; metal-binding site 545693003354 dimer interface [polypeptide binding]; other site 545693003355 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 545693003356 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 545693003357 putative metal binding site [ion binding]; other site 545693003358 putative dimer interface [polypeptide binding]; other site 545693003359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693003360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693003361 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693003362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693003363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693003364 putative substrate translocation pore; other site 545693003365 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693003366 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693003367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003368 ATP binding site [chemical binding]; other site 545693003369 Mg2+ binding site [ion binding]; other site 545693003370 G-X-G motif; other site 545693003371 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693003372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003373 active site 545693003374 phosphorylation site [posttranslational modification] 545693003375 intermolecular recognition site; other site 545693003376 dimerization interface [polypeptide binding]; other site 545693003377 LytTr DNA-binding domain; Region: LytTR; cl04498 545693003378 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693003379 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 545693003380 Walker A/P-loop; other site 545693003381 ATP binding site [chemical binding]; other site 545693003382 Q-loop/lid; other site 545693003383 ABC transporter signature motif; other site 545693003384 Walker B; other site 545693003385 D-loop; other site 545693003386 H-loop/switch region; other site 545693003387 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693003388 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693003389 Phosphotransferase enzyme family; Region: APH; pfam01636 545693003390 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 545693003391 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693003392 DNA binding residues [nucleotide binding] 545693003393 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693003394 Helix-turn-helix domains; Region: HTH; cl00088 545693003395 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 545693003396 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 545693003397 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 545693003398 Spore germination protein; Region: Spore_permease; cl15802 545693003399 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693003400 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693003401 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 545693003402 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 545693003403 dimer interface [polypeptide binding]; other site 545693003404 active site 545693003405 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 545693003406 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693003407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003408 active site 545693003409 phosphorylation site [posttranslational modification] 545693003410 intermolecular recognition site; other site 545693003411 dimerization interface [polypeptide binding]; other site 545693003412 LytTr DNA-binding domain; Region: LytTR; cl04498 545693003413 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 545693003414 PAS domain S-box; Region: sensory_box; TIGR00229 545693003415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003416 PAS domain S-box; Region: sensory_box; TIGR00229 545693003417 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693003418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003420 dimer interface [polypeptide binding]; other site 545693003421 phosphorylation site [posttranslational modification] 545693003422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003423 ATP binding site [chemical binding]; other site 545693003424 Mg2+ binding site [ion binding]; other site 545693003425 G-X-G motif; other site 545693003426 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 545693003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003428 active site 545693003429 phosphorylation site [posttranslational modification] 545693003430 intermolecular recognition site; other site 545693003431 dimerization interface [polypeptide binding]; other site 545693003432 Integral membrane protein TerC family; Region: TerC; cl10468 545693003433 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 545693003434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693003435 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693003436 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 545693003437 Helix-turn-helix domains; Region: HTH; cl00088 545693003438 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 545693003439 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693003440 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693003441 NAD(P) binding site [chemical binding]; other site 545693003442 homotetramer interface [polypeptide binding]; other site 545693003443 homodimer interface [polypeptide binding]; other site 545693003444 active site 545693003445 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 545693003446 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 545693003447 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 545693003448 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693003449 Cation transport protein; Region: TrkH; cl10514 545693003450 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 545693003451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693003452 Radical SAM superfamily; Region: Radical_SAM; pfam04055 545693003453 FeS/SAM binding site; other site 545693003454 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 545693003455 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693003456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693003457 DNA-binding site [nucleotide binding]; DNA binding site 545693003458 FCD domain; Region: FCD; cl11656 545693003459 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 545693003460 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 545693003461 active site 545693003462 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 545693003463 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 545693003464 homodimer interface [polypeptide binding]; other site 545693003465 NAD binding pocket [chemical binding]; other site 545693003466 ATP binding pocket [chemical binding]; other site 545693003467 Mg binding site [ion binding]; other site 545693003468 active-site loop [active] 545693003469 Cysteine-rich domain; Region: CCG; pfam02754 545693003470 Cysteine-rich domain; Region: CCG; pfam02754 545693003471 iron-sulfur cluster-binding protein; Region: TIGR00273 545693003472 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 545693003473 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 545693003474 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 545693003475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003476 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003478 putative active site [active] 545693003479 heme pocket [chemical binding]; other site 545693003480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003481 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 545693003482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693003483 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693003484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003485 dimer interface [polypeptide binding]; other site 545693003486 phosphorylation site [posttranslational modification] 545693003487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003488 ATP binding site [chemical binding]; other site 545693003489 Mg2+ binding site [ion binding]; other site 545693003490 G-X-G motif; other site 545693003491 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 545693003492 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 545693003493 DNA binding site [nucleotide binding] 545693003494 active site 545693003495 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 545693003496 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 545693003497 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693003498 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693003499 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693003500 putative active site [active] 545693003501 catalytic triad [active] 545693003502 putative dimer interface [polypeptide binding]; other site 545693003503 transaminase; Reviewed; Region: PRK08068 545693003504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693003505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003506 homodimer interface [polypeptide binding]; other site 545693003507 catalytic residue [active] 545693003508 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 545693003509 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 545693003510 dimer interface [polypeptide binding]; other site 545693003511 active site 545693003512 catalytic residue [active] 545693003513 metal binding site [ion binding]; metal-binding site 545693003514 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 545693003515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003516 active site 545693003517 motif I; other site 545693003518 motif II; other site 545693003519 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 545693003520 intersubunit interface [polypeptide binding]; other site 545693003521 active site 545693003522 Zn2+ binding site [ion binding]; other site 545693003523 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 545693003524 Cupin domain; Region: Cupin_2; cl09118 545693003525 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 545693003526 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693003527 putative ligand binding site [chemical binding]; other site 545693003528 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 545693003529 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 545693003530 Walker A/P-loop; other site 545693003531 ATP binding site [chemical binding]; other site 545693003532 Q-loop/lid; other site 545693003533 ABC transporter signature motif; other site 545693003534 Walker B; other site 545693003535 D-loop; other site 545693003536 H-loop/switch region; other site 545693003537 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 545693003538 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 545693003539 TM-ABC transporter signature motif; other site 545693003540 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 545693003541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003542 Protein of unknown function (DUF541); Region: SIMPL; cl01077 545693003543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003544 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 545693003545 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693003546 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 545693003547 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 545693003548 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 545693003549 nucleotide binding site/active site [active] 545693003550 HIT family signature motif; other site 545693003551 catalytic residue [active] 545693003552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693003553 Helix-turn-helix domains; Region: HTH; cl00088 545693003554 Helix-turn-helix domains; Region: HTH; cl00088 545693003555 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 545693003556 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 545693003557 active site 545693003558 Zn binding site [ion binding]; other site 545693003559 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693003560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693003561 putative active site [active] 545693003562 heme pocket [chemical binding]; other site 545693003563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693003564 dimer interface [polypeptide binding]; other site 545693003565 phosphorylation site [posttranslational modification] 545693003566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693003567 ATP binding site [chemical binding]; other site 545693003568 Mg2+ binding site [ion binding]; other site 545693003569 G-X-G motif; other site 545693003570 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 545693003571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003572 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 545693003573 Walker A motif; other site 545693003574 ATP binding site [chemical binding]; other site 545693003575 Walker B motif; other site 545693003576 arginine finger; other site 545693003577 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 545693003578 UvrB/uvrC motif; Region: UVR; pfam02151 545693003579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693003580 Walker A motif; other site 545693003581 ATP binding site [chemical binding]; other site 545693003582 Walker B motif; other site 545693003583 arginine finger; other site 545693003584 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 545693003585 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 545693003586 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693003587 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 545693003588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693003589 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 545693003590 classical (c) SDRs; Region: SDR_c; cd05233 545693003591 NAD(P) binding site [chemical binding]; other site 545693003592 active site 545693003593 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693003594 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693003595 Spore germination protein; Region: Spore_permease; cl15802 545693003596 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 545693003597 Ligand Binding Site [chemical binding]; other site 545693003598 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 545693003599 active site 545693003600 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 545693003601 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 545693003602 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 545693003603 NAD binding site [chemical binding]; other site 545693003604 active site 545693003605 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 545693003606 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 545693003607 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 545693003608 active site 545693003609 nucleophile elbow; other site 545693003610 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693003611 putative peptidoglycan binding site; other site 545693003612 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693003613 potential frameshift: common BLAST hit: gi|52787060|ref|YP_092889.1| YueI 545693003614 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 545693003615 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 545693003616 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693003617 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 545693003618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003619 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693003620 active site 545693003621 motif I; other site 545693003622 motif II; other site 545693003623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003624 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 545693003625 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 545693003626 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 545693003627 substrate binding pocket [chemical binding]; other site 545693003628 dimer interface [polypeptide binding]; other site 545693003629 inhibitor binding site; inhibition site 545693003630 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 545693003631 B12 binding site [chemical binding]; other site 545693003632 cobalt ligand [ion binding]; other site 545693003633 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 545693003634 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 545693003635 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 545693003636 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 545693003637 FAD binding site [chemical binding]; other site 545693003638 Uncharacterized membrane protein [Function unknown]; Region: COG3949 545693003639 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 545693003640 Lumazine binding domain; Region: Lum_binding; pfam00677 545693003641 Lumazine binding domain; Region: Lum_binding; pfam00677 545693003642 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 545693003643 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 545693003644 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 545693003645 dimerization interface [polypeptide binding]; other site 545693003646 active site 545693003647 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 545693003648 homopentamer interface [polypeptide binding]; other site 545693003649 active site 545693003650 transcriptional antiterminator BglG; Provisional; Region: PRK09772 545693003651 CAT RNA binding domain; Region: CAT_RBD; cl03904 545693003652 PRD domain; Region: PRD; cl15445 545693003653 PRD domain; Region: PRD; cl15445 545693003654 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693003655 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 545693003656 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693003657 active site turn [active] 545693003658 phosphorylation site [posttranslational modification] 545693003659 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 545693003660 HPr interaction site; other site 545693003661 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693003662 active site 545693003663 phosphorylation site [posttranslational modification] 545693003664 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693003665 dimerization domain swap beta strand [polypeptide binding]; other site 545693003666 regulatory protein interface [polypeptide binding]; other site 545693003667 active site 545693003668 regulatory phosphorylation site [posttranslational modification]; other site 545693003669 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 545693003670 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 545693003671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 545693003672 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 545693003673 LrgB-like family; Region: LrgB; cl00596 545693003674 LrgA family; Region: LrgA; cl00608 545693003675 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 545693003676 Helix-turn-helix domains; Region: HTH; cl00088 545693003677 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693003678 putative dimerization interface [polypeptide binding]; other site 545693003679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693003680 Coenzyme A binding pocket [chemical binding]; other site 545693003681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693003682 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 545693003683 putative NAD(P) binding site [chemical binding]; other site 545693003684 putative active site [active] 545693003685 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693003686 dimer interface [polypeptide binding]; other site 545693003687 FMN binding site [chemical binding]; other site 545693003688 aminotransferase A; Validated; Region: PRK07683 545693003689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693003690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003691 homodimer interface [polypeptide binding]; other site 545693003692 catalytic residue [active] 545693003693 hypothetical protein; Provisional; Region: PRK03636 545693003694 IDEAL domain; Region: IDEAL; cl07452 545693003695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693003696 Helix-turn-helix domains; Region: HTH; cl00088 545693003697 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 545693003698 putative CheA interaction surface; other site 545693003699 Response regulator receiver domain; Region: Response_reg; pfam00072 545693003700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693003701 active site 545693003702 phosphorylation site [posttranslational modification] 545693003703 intermolecular recognition site; other site 545693003704 dimerization interface [polypeptide binding]; other site 545693003705 YkyB-like protein; Region: YkyB; pfam14177 545693003706 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693003707 putative peptidoglycan binding site; other site 545693003708 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693003709 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 545693003710 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 545693003711 polyphosphate kinase; Provisional; Region: PRK05443 545693003712 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 545693003713 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 545693003714 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 545693003715 putative domain interface [polypeptide binding]; other site 545693003716 putative active site [active] 545693003717 catalytic site [active] 545693003718 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 545693003719 putative domain interface [polypeptide binding]; other site 545693003720 putative active site [active] 545693003721 catalytic site [active] 545693003722 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693003723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693003724 putative active site [active] 545693003725 putative metal binding site [ion binding]; other site 545693003726 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 545693003727 short chain dehydrogenase; Provisional; Region: PRK07677 545693003728 NAD(P) binding site [chemical binding]; other site 545693003729 substrate binding site [chemical binding]; other site 545693003730 homotetramer interface [polypeptide binding]; other site 545693003731 active site 545693003732 homodimer interface [polypeptide binding]; other site 545693003733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693003734 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 545693003735 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 545693003736 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 545693003737 catalytic residues [active] 545693003738 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 545693003739 FOG: CBS domain [General function prediction only]; Region: COG0517 545693003740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693003741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693003742 Helix-turn-helix domains; Region: HTH; cl00088 545693003743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693003744 dimerization interface [polypeptide binding]; other site 545693003745 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 545693003746 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 545693003747 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 545693003748 active site 545693003749 trimer interface [polypeptide binding]; other site 545693003750 substrate binding site [chemical binding]; other site 545693003751 CoA binding site [chemical binding]; other site 545693003752 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693003753 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 545693003754 metal binding site [ion binding]; metal-binding site 545693003755 putative dimer interface [polypeptide binding]; other site 545693003756 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 545693003757 mechanosensitive channel MscS; Provisional; Region: PRK10334 545693003758 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693003759 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 545693003760 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 545693003761 dimer interface [polypeptide binding]; other site 545693003762 decamer (pentamer of dimers) interface [polypeptide binding]; other site 545693003763 catalytic triad [active] 545693003764 peroxidatic and resolving cysteines [active] 545693003765 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693003766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003767 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 545693003768 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693003769 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693003770 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 545693003771 Walker A/P-loop; other site 545693003772 ATP binding site [chemical binding]; other site 545693003773 Q-loop/lid; other site 545693003774 ABC transporter signature motif; other site 545693003775 Walker B; other site 545693003776 D-loop; other site 545693003777 H-loop/switch region; other site 545693003778 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693003779 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693003780 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 545693003781 Walker A/P-loop; other site 545693003782 ATP binding site [chemical binding]; other site 545693003783 Q-loop/lid; other site 545693003784 ABC transporter signature motif; other site 545693003785 Walker B; other site 545693003786 D-loop; other site 545693003787 H-loop/switch region; other site 545693003788 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693003789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003790 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693003791 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693003792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693003793 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 545693003794 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 545693003795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693003797 active site 545693003798 motif I; other site 545693003799 motif II; other site 545693003800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693003801 motif II; other site 545693003802 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 545693003803 active site 545693003804 catalytic residues [active] 545693003805 metal binding site [ion binding]; metal-binding site 545693003806 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 545693003807 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 545693003808 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693003809 TPP-binding site [chemical binding]; other site 545693003810 tetramer interface [polypeptide binding]; other site 545693003811 heterodimer interface [polypeptide binding]; other site 545693003812 phosphorylation loop region [posttranslational modification] 545693003813 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693003814 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693003815 alpha subunit interface [polypeptide binding]; other site 545693003816 TPP binding site [chemical binding]; other site 545693003817 heterodimer interface [polypeptide binding]; other site 545693003818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693003819 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693003820 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693003821 E3 interaction surface; other site 545693003822 lipoyl attachment site [posttranslational modification]; other site 545693003823 e3 binding domain; Region: E3_binding; pfam02817 545693003824 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 545693003825 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 545693003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693003828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 545693003829 glycine/betaine transporter, point mutation 545693003830 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 545693003831 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 545693003832 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 545693003833 homodimer interface [polypeptide binding]; other site 545693003834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003835 catalytic residue [active] 545693003836 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 545693003837 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 545693003838 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 545693003839 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 545693003840 active site 545693003841 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 545693003842 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 545693003843 G1 box; other site 545693003844 putative GEF interaction site [polypeptide binding]; other site 545693003845 GTP/Mg2+ binding site [chemical binding]; other site 545693003846 Switch I region; other site 545693003847 G2 box; other site 545693003848 G3 box; other site 545693003849 Switch II region; other site 545693003850 G4 box; other site 545693003851 G5 box; other site 545693003852 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 545693003853 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 545693003854 YlaH-like protein; Region: YlaH; pfam14036 545693003855 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 545693003856 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693003857 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693003858 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693003859 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 545693003860 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 545693003861 putative active site [active] 545693003862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693003863 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 545693003864 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 545693003865 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 545693003866 pyruvate carboxylase; Reviewed; Region: PRK12999 545693003867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693003868 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693003869 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 545693003870 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 545693003871 active site 545693003872 catalytic residues [active] 545693003873 metal binding site [ion binding]; metal-binding site 545693003874 homodimer binding site [polypeptide binding]; other site 545693003875 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693003876 carboxyltransferase (CT) interaction site; other site 545693003877 biotinylation site [posttranslational modification]; other site 545693003878 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 545693003879 UbiA prenyltransferase family; Region: UbiA; cl00337 545693003880 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 545693003881 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 545693003882 Cytochrome c; Region: Cytochrom_C; cl11414 545693003883 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693003884 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693003885 D-pathway; other site 545693003886 Putative ubiquinol binding site [chemical binding]; other site 545693003887 Low-spin heme (heme b) binding site [chemical binding]; other site 545693003888 Putative water exit pathway; other site 545693003889 Binuclear center (heme o3/CuB) [ion binding]; other site 545693003890 K-pathway; other site 545693003891 Putative proton exit pathway; other site 545693003892 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693003893 Subunit I/III interface [polypeptide binding]; other site 545693003894 Subunit III/IV interface [polypeptide binding]; other site 545693003895 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693003896 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 545693003897 YugN-like family; Region: YugN; pfam08868 545693003898 FOG: CBS domain [General function prediction only]; Region: COG0517 545693003899 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 545693003900 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 545693003901 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693003902 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 545693003903 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 545693003904 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693003905 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693003906 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693003907 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 545693003908 dihydrodipicolinate reductase; Provisional; Region: PRK00048 545693003909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693003910 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 545693003911 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 545693003912 active site 545693003913 dimer interfaces [polypeptide binding]; other site 545693003914 catalytic residues [active] 545693003915 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 545693003916 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 545693003917 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 545693003918 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 545693003919 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 545693003920 active site 545693003921 NTP binding site [chemical binding]; other site 545693003922 metal binding triad [ion binding]; metal-binding site 545693003923 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 545693003924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693003925 Helix-turn-helix domains; Region: HTH; cl00088 545693003926 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 545693003927 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 545693003928 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 545693003929 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 545693003930 oligomerization interface [polypeptide binding]; other site 545693003931 active site 545693003932 metal binding site [ion binding]; metal-binding site 545693003933 pantoate--beta-alanine ligase; Region: panC; TIGR00018 545693003934 Pantoate-beta-alanine ligase; Region: PanC; cd00560 545693003935 active site 545693003936 ATP-binding site [chemical binding]; other site 545693003937 pantoate-binding site; other site 545693003938 HXXH motif; other site 545693003939 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 545693003940 tetramerization interface [polypeptide binding]; other site 545693003941 active site 545693003942 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 545693003943 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693003944 active site 545693003945 catalytic site [active] 545693003946 substrate binding site [chemical binding]; other site 545693003947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693003948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693003949 putative Mg++ binding site [ion binding]; other site 545693003950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693003951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693003952 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 545693003953 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693003954 aspartate aminotransferase; Provisional; Region: PRK05764 545693003955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693003956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003957 homodimer interface [polypeptide binding]; other site 545693003958 catalytic residue [active] 545693003959 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 545693003960 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 545693003961 putative dimer interface [polypeptide binding]; other site 545693003962 putative anticodon binding site; other site 545693003963 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 545693003964 homodimer interface [polypeptide binding]; other site 545693003965 motif 1; other site 545693003966 motif 2; other site 545693003967 active site 545693003968 motif 3; other site 545693003969 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 545693003970 Helix-turn-helix domains; Region: HTH; cl00088 545693003971 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 545693003972 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 545693003973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 545693003974 minor groove reading motif; other site 545693003975 helix-hairpin-helix signature motif; other site 545693003976 substrate binding pocket [chemical binding]; other site 545693003977 active site 545693003978 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 545693003979 Transglycosylase; Region: Transgly; cl07896 545693003980 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693003981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693003982 Recombination protein U; Region: RecU; cl01314 545693003983 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 545693003984 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 545693003985 YppF-like protein; Region: YppF; pfam14178 545693003986 YppG-like protein; Region: YppG; pfam14179 545693003987 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 545693003988 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 545693003989 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693003990 homodimer interface [polypeptide binding]; other site 545693003991 substrate-cofactor binding pocket; other site 545693003992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003993 catalytic residue [active] 545693003994 cystathionine beta-lyase; Provisional; Region: PRK07671 545693003995 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693003996 homodimer interface [polypeptide binding]; other site 545693003997 substrate-cofactor binding pocket; other site 545693003998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693003999 catalytic residue [active] 545693004000 Protein of unknown function (DUF541); Region: SIMPL; cl01077 545693004001 Sodium:solute symporter family; Region: SSF; cl00456 545693004002 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693004003 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693004004 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693004005 DNA-binding site [nucleotide binding]; DNA binding site 545693004006 RNA-binding motif; other site 545693004007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693004008 metal binding site [ion binding]; metal-binding site 545693004009 active site 545693004010 I-site; other site 545693004011 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 545693004012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693004013 ATP binding site [chemical binding]; other site 545693004014 putative Mg++ binding site [ion binding]; other site 545693004015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693004016 nucleotide binding region [chemical binding]; other site 545693004017 ATP-binding site [chemical binding]; other site 545693004018 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 545693004019 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 545693004020 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 545693004021 active site 545693004022 substrate binding site [chemical binding]; other site 545693004023 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 545693004024 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 545693004025 cell division protein GpsB; Provisional; Region: PRK14127 545693004026 DivIVA domain; Region: DivI1A_domain; TIGR03544 545693004027 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 545693004028 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 545693004029 Predicted membrane protein [Function unknown]; Region: COG4758 545693004030 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 545693004031 Histidine kinase; Region: HisKA_3; pfam07730 545693004032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004033 ATP binding site [chemical binding]; other site 545693004034 Mg2+ binding site [ion binding]; other site 545693004035 G-X-G motif; other site 545693004036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004038 active site 545693004039 phosphorylation site [posttranslational modification] 545693004040 intermolecular recognition site; other site 545693004041 dimerization interface [polypeptide binding]; other site 545693004042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693004043 DNA binding residues [nucleotide binding] 545693004044 dimerization interface [polypeptide binding]; other site 545693004045 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 545693004046 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 545693004047 Ca binding site [ion binding]; other site 545693004048 active site 545693004049 catalytic site [active] 545693004050 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 545693004051 THUMP domain; Region: THUMP; cl12076 545693004052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004054 dimer interface [polypeptide binding]; other site 545693004055 conserved gate region; other site 545693004056 ABC-ATPase subunit interface; other site 545693004057 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 545693004058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004059 dimer interface [polypeptide binding]; other site 545693004060 conserved gate region; other site 545693004061 putative PBP binding loops; other site 545693004062 ABC-ATPase subunit interface; other site 545693004063 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693004064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693004065 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693004066 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 545693004067 Walker A/P-loop; other site 545693004068 ATP binding site [chemical binding]; other site 545693004069 Q-loop/lid; other site 545693004070 ABC transporter signature motif; other site 545693004071 Walker B; other site 545693004072 D-loop; other site 545693004073 H-loop/switch region; other site 545693004074 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 545693004075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693004076 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 545693004077 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 545693004078 active site 545693004079 Zn binding site [ion binding]; other site 545693004080 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 545693004081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693004082 active site 545693004083 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 545693004084 xanthine permease; Region: pbuX; TIGR03173 545693004085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004086 Helix-turn-helix domains; Region: HTH; cl00088 545693004087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693004088 dimerization interface [polypeptide binding]; other site 545693004089 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693004090 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 545693004091 tetramerization interface [polypeptide binding]; other site 545693004092 NAD(P) binding site [chemical binding]; other site 545693004093 catalytic residues [active] 545693004094 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 545693004095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004096 Coenzyme A binding pocket [chemical binding]; other site 545693004097 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 545693004098 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 545693004099 malonyl-CoA binding site [chemical binding]; other site 545693004100 dimer interface [polypeptide binding]; other site 545693004101 active site 545693004102 product binding site; other site 545693004103 Phospholipid methyltransferase; Region: PEMT; cl00763 545693004104 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 545693004105 Dynamin family; Region: Dynamin_N; pfam00350 545693004106 G1 box; other site 545693004107 GTP/Mg2+ binding site [chemical binding]; other site 545693004108 G2 box; other site 545693004109 Switch I region; other site 545693004110 G3 box; other site 545693004111 Switch II region; other site 545693004112 G4 box; other site 545693004113 G5 box; other site 545693004114 Predicted GTPases [General function prediction only]; Region: COG1161 545693004115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693004116 Dynamin family; Region: Dynamin_N; pfam00350 545693004117 G1 box; other site 545693004118 GTP/Mg2+ binding site [chemical binding]; other site 545693004119 G2 box; other site 545693004120 Switch I region; other site 545693004121 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 545693004122 G3 box; other site 545693004123 Switch II region; other site 545693004124 GTP/Mg2+ binding site [chemical binding]; other site 545693004125 G4 box; other site 545693004126 G5 box; other site 545693004127 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 545693004128 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 545693004129 Divergent PAP2 family; Region: DUF212; cl00855 545693004130 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 545693004131 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693004132 active site 545693004133 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 545693004134 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693004135 active site 545693004136 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 545693004137 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 545693004138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693004139 DNA-binding site [nucleotide binding]; DNA binding site 545693004140 RNA-binding motif; other site 545693004141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004143 putative substrate translocation pore; other site 545693004144 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 545693004145 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 545693004146 putative active site [active] 545693004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693004148 TPR motif; other site 545693004149 TPR repeat; Region: TPR_11; pfam13414 545693004150 binding surface 545693004151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004152 binding surface 545693004153 TPR motif; other site 545693004154 TPR repeat; Region: TPR_11; pfam13414 545693004155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004156 binding surface 545693004157 TPR motif; other site 545693004158 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693004159 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 545693004160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004161 binding surface 545693004162 TPR motif; other site 545693004163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693004164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693004165 binding surface 545693004166 TPR motif; other site 545693004167 putative uracil/xanthine transporter; Provisional; Region: PRK11412 545693004168 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 545693004169 SxDxEG motif; other site 545693004170 active site 545693004171 metal binding site [ion binding]; metal-binding site 545693004172 homopentamer interface [polypeptide binding]; other site 545693004173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693004174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004175 dimer interface [polypeptide binding]; other site 545693004176 conserved gate region; other site 545693004177 putative PBP binding loops; other site 545693004178 ABC-ATPase subunit interface; other site 545693004179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693004180 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004182 dimer interface [polypeptide binding]; other site 545693004183 conserved gate region; other site 545693004184 putative PBP binding loops; other site 545693004185 ABC-ATPase subunit interface; other site 545693004186 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693004187 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693004188 Walker A/P-loop; other site 545693004189 ATP binding site [chemical binding]; other site 545693004190 Q-loop/lid; other site 545693004191 ABC transporter signature motif; other site 545693004192 Walker B; other site 545693004193 D-loop; other site 545693004194 H-loop/switch region; other site 545693004195 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693004196 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 545693004197 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 545693004198 peptide binding site [polypeptide binding]; other site 545693004199 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 545693004200 dimer interface [polypeptide binding]; other site 545693004201 catalytic triad [active] 545693004202 NlpC/P60 family; Region: NLPC_P60; cl11438 545693004203 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 545693004204 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693004205 Walker A/P-loop; other site 545693004206 ATP binding site [chemical binding]; other site 545693004207 Q-loop/lid; other site 545693004208 ABC transporter signature motif; other site 545693004209 Walker B; other site 545693004210 D-loop; other site 545693004211 H-loop/switch region; other site 545693004212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693004213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693004214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693004215 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693004216 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 545693004217 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 545693004218 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 545693004219 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 545693004220 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693004221 PAS domain S-box; Region: sensory_box; TIGR00229 545693004222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693004223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693004224 metal binding site [ion binding]; metal-binding site 545693004225 active site 545693004226 I-site; other site 545693004227 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693004228 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693004229 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 545693004230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693004231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004232 active site 545693004233 phosphorylation site [posttranslational modification] 545693004234 intermolecular recognition site; other site 545693004235 dimerization interface [polypeptide binding]; other site 545693004236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693004237 DNA binding residues [nucleotide binding] 545693004238 dimerization interface [polypeptide binding]; other site 545693004239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693004240 Histidine kinase; Region: HisKA_3; pfam07730 545693004241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 545693004242 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 545693004243 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 545693004244 putative di-iron ligands [ion binding]; other site 545693004245 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 545693004246 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 545693004247 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693004248 putative active site [active] 545693004249 catalytic site [active] 545693004250 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693004251 putative active site [active] 545693004252 catalytic site [active] 545693004253 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 545693004254 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 545693004255 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693004256 Bacterial SH3 domain; Region: SH3_3; cl02551 545693004257 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693004258 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693004259 putative peptidoglycan binding site; other site 545693004260 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693004261 putative peptidoglycan binding site; other site 545693004262 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 545693004263 active site 545693004264 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693004265 glycosyltransferase, MGT family; Region: MGT; TIGR01426 545693004266 active site 545693004267 TDP-binding site; other site 545693004268 acceptor substrate-binding pocket; other site 545693004269 homodimer interface [polypeptide binding]; other site 545693004270 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 545693004271 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693004272 active site 545693004273 tetramer interface; other site 545693004274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004275 sugar efflux transporter; Region: 2A0120; TIGR00899 545693004276 putative substrate translocation pore; other site 545693004277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004279 putative substrate translocation pore; other site 545693004280 Protein of unknown function, DUF393; Region: DUF393; cl01136 545693004281 short chain dehydrogenase; Provisional; Region: PRK06197 545693004282 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 545693004283 putative NAD(P) binding site [chemical binding]; other site 545693004284 active site 545693004285 dihydroorotase; Provisional; Region: PRK09237 545693004286 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 545693004287 active site 545693004288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693004289 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 545693004290 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693004291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693004292 substrate binding site [chemical binding]; other site 545693004293 ATP binding site [chemical binding]; other site 545693004294 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693004295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004296 DNA-binding site [nucleotide binding]; DNA binding site 545693004297 UTRA domain; Region: UTRA; cl01230 545693004298 GntP family permease; Region: GntP_permease; pfam02447 545693004299 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693004300 BtpA family; Region: BtpA; cl00440 545693004301 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693004302 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004303 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004304 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 545693004305 dimer interface [polypeptide binding]; other site 545693004306 Alkaline phosphatase homologues; Region: alkPPc; smart00098 545693004307 active site 545693004308 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 545693004309 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 545693004310 catalytic residues [active] 545693004311 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 545693004312 active site 545693004313 catalytic residues [active] 545693004314 Endonuclease I; Region: Endonuclease_1; cl01003 545693004315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004316 Helix-turn-helix domains; Region: HTH; cl00088 545693004317 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693004318 E3 interaction surface; other site 545693004319 lipoyl attachment site [posttranslational modification]; other site 545693004320 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 545693004321 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004323 putative substrate translocation pore; other site 545693004324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004326 Helix-turn-helix domains; Region: HTH; cl00088 545693004327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693004328 non-specific DNA binding site [nucleotide binding]; other site 545693004329 salt bridge; other site 545693004330 sequence-specific DNA binding site [nucleotide binding]; other site 545693004331 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 545693004332 YfhD-like protein; Region: YfhD; pfam14151 545693004333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693004334 ABC-ATPase subunit interface; other site 545693004335 dimer interface [polypeptide binding]; other site 545693004336 putative PBP binding regions; other site 545693004337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693004338 ABC-ATPase subunit interface; other site 545693004339 dimer interface [polypeptide binding]; other site 545693004340 putative PBP binding regions; other site 545693004341 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 545693004342 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 545693004343 putative ligand binding residues [chemical binding]; other site 545693004344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693004345 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693004346 Walker A/P-loop; other site 545693004347 ATP binding site [chemical binding]; other site 545693004348 Q-loop/lid; other site 545693004349 ABC transporter signature motif; other site 545693004350 Walker B; other site 545693004351 D-loop; other site 545693004352 H-loop/switch region; other site 545693004353 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693004354 methionine gamma-lyase; Provisional; Region: PRK06767 545693004355 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693004356 homodimer interface [polypeptide binding]; other site 545693004357 substrate-cofactor binding pocket; other site 545693004358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004359 catalytic residue [active] 545693004360 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 545693004361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004362 putative substrate translocation pore; other site 545693004363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693004364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693004365 active site 545693004366 catalytic tetrad [active] 545693004367 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 545693004368 active site 2 [active] 545693004369 active site 1 [active] 545693004370 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693004371 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693004372 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693004373 Helix-turn-helix domains; Region: HTH; cl00088 545693004374 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693004375 active site 545693004376 dimer interface [polypeptide binding]; other site 545693004377 magnesium binding site [ion binding]; other site 545693004378 FAD dependent oxidoreductase; Region: DAO; pfam01266 545693004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004380 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 545693004381 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693004382 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 545693004383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004384 Herpes DNA replication accessory factor; Region: Herpes_DNAp_acc; pfam04929 545693004385 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693004386 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 545693004387 [2Fe-2S] cluster binding site [ion binding]; other site 545693004388 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 545693004389 putative alpha subunit interface [polypeptide binding]; other site 545693004390 putative active site [active] 545693004391 putative substrate binding site [chemical binding]; other site 545693004392 Fe binding site [ion binding]; other site 545693004393 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 545693004394 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 545693004395 Walker A/P-loop; other site 545693004396 ATP binding site [chemical binding]; other site 545693004397 Q-loop/lid; other site 545693004398 ABC transporter signature motif; other site 545693004399 Walker B; other site 545693004400 D-loop; other site 545693004401 H-loop/switch region; other site 545693004402 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 545693004403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004404 dimer interface [polypeptide binding]; other site 545693004405 conserved gate region; other site 545693004406 ABC-ATPase subunit interface; other site 545693004407 NMT1-like family; Region: NMT1_2; cl15260 545693004408 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 545693004409 CHASE3 domain; Region: CHASE3; cl05000 545693004410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693004411 GAF domain; Region: GAF_2; pfam13185 545693004412 GAF domain; Region: GAF; cl15785 545693004413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693004414 dimer interface [polypeptide binding]; other site 545693004415 phosphorylation site [posttranslational modification] 545693004416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004417 ATP binding site [chemical binding]; other site 545693004418 Mg2+ binding site [ion binding]; other site 545693004419 G-X-G motif; other site 545693004420 Response regulator receiver domain; Region: Response_reg; pfam00072 545693004421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004422 active site 545693004423 phosphorylation site [posttranslational modification] 545693004424 intermolecular recognition site; other site 545693004425 dimerization interface [polypeptide binding]; other site 545693004426 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693004427 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 545693004428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004429 Response regulator receiver domain; Region: Response_reg; pfam00072 545693004430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004431 active site 545693004432 phosphorylation site [posttranslational modification] 545693004433 intermolecular recognition site; other site 545693004434 dimerization interface [polypeptide binding]; other site 545693004435 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 545693004436 LysE type translocator; Region: LysE; cl00565 545693004437 amino acid transporter; Region: 2A0306; TIGR00909 545693004438 Spore germination protein; Region: Spore_permease; cl15802 545693004439 Spore germination protein; Region: Spore_permease; cl15802 545693004440 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693004441 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693004442 ligand binding site [chemical binding]; other site 545693004443 flexible hinge region; other site 545693004444 Helix-turn-helix domains; Region: HTH; cl00088 545693004445 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 545693004446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693004447 active site 545693004448 motif I; other site 545693004449 motif II; other site 545693004450 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693004451 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 545693004452 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 545693004453 active site 545693004454 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 545693004455 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004456 substrate binding [chemical binding]; other site 545693004457 active site 545693004458 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004459 Ferritin-like domain; Region: Ferritin; pfam00210 545693004460 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 545693004461 dinuclear metal binding motif [ion binding]; other site 545693004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004463 putative substrate translocation pore; other site 545693004464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004466 putative substrate translocation pore; other site 545693004467 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 545693004468 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 545693004469 substrate-cofactor binding pocket; other site 545693004470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693004471 catalytic residue [active] 545693004472 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693004473 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 545693004474 NAD binding site [chemical binding]; other site 545693004475 homodimer interface [polypeptide binding]; other site 545693004476 active site 545693004477 putative substrate binding site [chemical binding]; other site 545693004478 HutP; Region: HutP; cl07944 545693004479 benzoate transport; Region: 2A0115; TIGR00895 545693004480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004481 putative substrate translocation pore; other site 545693004482 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693004483 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 545693004484 potential catalytic triad [active] 545693004485 conserved cys residue [active] 545693004486 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693004487 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 545693004488 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693004489 NAD binding site [chemical binding]; other site 545693004490 catalytic residues [active] 545693004491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693004492 LysE type translocator; Region: LysE; cl00565 545693004493 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693004494 Spore germination protein; Region: Spore_permease; cl15802 545693004495 YpzG-like protein; Region: YpzG; pfam14139 545693004496 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693004497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693004498 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 545693004499 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 545693004500 putative transport protein YifK; Provisional; Region: PRK10746 545693004501 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693004502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693004503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693004504 DNA binding site [nucleotide binding] 545693004505 domain linker motif; other site 545693004506 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 545693004507 dimerization interface [polypeptide binding]; other site 545693004508 ligand binding site [chemical binding]; other site 545693004509 sodium binding site [ion binding]; other site 545693004510 galactoside permease; Reviewed; Region: lacY; PRK09528 545693004511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004512 putative substrate translocation pore; other site 545693004513 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 545693004514 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004515 substrate binding [chemical binding]; other site 545693004516 active site 545693004517 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004518 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 545693004519 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 545693004520 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 545693004521 active site 545693004522 Helix-turn-helix domains; Region: HTH; cl00088 545693004523 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 545693004524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693004525 Walker A motif; other site 545693004526 ATP binding site [chemical binding]; other site 545693004527 Walker B motif; other site 545693004528 arginine finger; other site 545693004529 Transcriptional antiterminator [Transcription]; Region: COG3933 545693004530 PRD domain; Region: PRD; cl15445 545693004531 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 545693004532 active pocket/dimerization site; other site 545693004533 active site 545693004534 phosphorylation site [posttranslational modification] 545693004535 PRD domain; Region: PRD; cl15445 545693004536 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 545693004537 active pocket/dimerization site; other site 545693004538 active site 545693004539 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 545693004540 active site 545693004541 phosphorylation site [posttranslational modification] 545693004542 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 545693004543 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 545693004544 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693004545 substrate binding [chemical binding]; other site 545693004546 active site 545693004547 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 545693004548 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 545693004549 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693004550 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 545693004551 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693004552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004553 dimer interface [polypeptide binding]; other site 545693004554 conserved gate region; other site 545693004555 putative PBP binding loops; other site 545693004556 ABC-ATPase subunit interface; other site 545693004557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004558 dimer interface [polypeptide binding]; other site 545693004559 conserved gate region; other site 545693004560 putative PBP binding loops; other site 545693004561 ABC-ATPase subunit interface; other site 545693004562 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693004563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693004564 substrate binding pocket [chemical binding]; other site 545693004565 membrane-bound complex binding site; other site 545693004566 hinge residues; other site 545693004567 NMT1-like family; Region: NMT1_2; cl15260 545693004568 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 545693004569 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 545693004570 Walker A/P-loop; other site 545693004571 ATP binding site [chemical binding]; other site 545693004572 Q-loop/lid; other site 545693004573 ABC transporter signature motif; other site 545693004574 Walker B; other site 545693004575 D-loop; other site 545693004576 H-loop/switch region; other site 545693004577 NIL domain; Region: NIL; cl09633 545693004578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 545693004579 NMT1-like family; Region: NMT1_2; cl15260 545693004580 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693004581 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 545693004582 active site 545693004583 non-prolyl cis peptide bond; other site 545693004584 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 545693004585 active site 545693004586 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 545693004587 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004589 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 545693004590 active site 545693004591 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693004592 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693004593 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 545693004594 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693004595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004596 DNA-binding site [nucleotide binding]; DNA binding site 545693004597 UTRA domain; Region: UTRA; cl01230 545693004598 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 545693004599 putative deacylase active site [active] 545693004600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693004601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693004602 active site 545693004603 catalytic tetrad [active] 545693004604 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 545693004605 active sites [active] 545693004606 tetramer interface [polypeptide binding]; other site 545693004607 urocanate hydratase; Provisional; Region: PRK05414 545693004608 imidazolonepropionase; Validated; Region: PRK09356 545693004609 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 545693004610 active site 545693004611 Arginase family; Region: Arginase; cl00306 545693004612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004613 Helix-turn-helix domains; Region: HTH; cl00088 545693004614 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 545693004615 active site 545693004616 tetramer interface [polypeptide binding]; other site 545693004617 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 545693004618 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693004619 isoaspartyl dipeptidase; Provisional; Region: PRK10657 545693004620 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693004621 active site 545693004622 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 545693004623 proposed catalytic triad [active] 545693004624 active site nucleophile [active] 545693004625 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 545693004626 proposed catalytic triad [active] 545693004627 active site nucleophile [active] 545693004628 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693004629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693004630 Walker A motif; other site 545693004631 ATP binding site [chemical binding]; other site 545693004632 Walker B motif; other site 545693004633 arginine finger; other site 545693004634 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 545693004635 exopeptidase, frameshift 545693004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004637 putative substrate translocation pore; other site 545693004638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004639 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693004640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693004641 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693004642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004643 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693004644 Coenzyme A binding pocket [chemical binding]; other site 545693004645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004647 Coenzyme A binding pocket [chemical binding]; other site 545693004648 Predicted membrane protein [Function unknown]; Region: COG2364 545693004649 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004650 Helix-turn-helix domains; Region: HTH; cl00088 545693004651 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693004652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693004653 Coenzyme A binding pocket [chemical binding]; other site 545693004654 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693004655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693004656 motif II; other site 545693004657 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693004658 phosphoenolpyruvate synthase; Validated; Region: PRK06241 545693004659 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693004660 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 545693004661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693004662 Helix-turn-helix domains; Region: HTH; cl00088 545693004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693004665 putative substrate translocation pore; other site 545693004666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004667 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693004668 TPP-binding site [chemical binding]; other site 545693004669 dimer interface [polypeptide binding]; other site 545693004670 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 545693004671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693004672 PYR/PP interface [polypeptide binding]; other site 545693004673 dimer interface [polypeptide binding]; other site 545693004674 TPP binding site [chemical binding]; other site 545693004675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693004676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693004677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004678 NAD(P) binding site [chemical binding]; other site 545693004679 active site 545693004680 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693004681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693004682 DNA-binding site [nucleotide binding]; DNA binding site 545693004683 FCD domain; Region: FCD; cl11656 545693004684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004685 D-galactonate transporter; Region: 2A0114; TIGR00893 545693004686 putative substrate translocation pore; other site 545693004687 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 545693004688 active site 545693004689 ADP/pyrophosphate binding site [chemical binding]; other site 545693004690 dimerization interface [polypeptide binding]; other site 545693004691 allosteric effector site; other site 545693004692 fructose-1,6-bisphosphate binding site; other site 545693004693 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 545693004694 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 545693004695 nudix motif; other site 545693004696 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 545693004697 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 545693004698 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693004699 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693004700 NlpC/P60 family; Region: NLPC_P60; cl11438 545693004701 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 545693004702 putative active site [active] 545693004703 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693004704 DinB superfamily; Region: DinB_2; pfam12867 545693004705 phosphoribulokinase/uridine kinase; Region: PLN02318 545693004706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004707 Helix-turn-helix domains; Region: HTH; cl00088 545693004708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693004709 dimerization interface [polypeptide binding]; other site 545693004710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693004712 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004713 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 545693004714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693004715 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004716 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693004717 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 545693004718 classical (c) SDRs; Region: SDR_c; cd05233 545693004719 NAD(P) binding site [chemical binding]; other site 545693004720 active site 545693004721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693004722 active site 545693004723 substrate binding site [chemical binding]; other site 545693004724 ATP binding site [chemical binding]; other site 545693004725 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 545693004726 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693004727 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 545693004728 NodB motif; other site 545693004729 putative active site [active] 545693004730 putative catalytic site [active] 545693004731 putative Zn binding site [ion binding]; other site 545693004732 Spore germination protein; Region: Spore_permease; cl15802 545693004733 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693004734 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693004735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693004736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693004737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693004738 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693004739 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 545693004740 calcium/proton exchanger (cax); Region: cax; TIGR00378 545693004741 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693004742 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 545693004743 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 545693004744 AMP-binding enzyme; Region: AMP-binding; cl15778 545693004745 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693004746 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 545693004747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693004748 Helix-turn-helix domains; Region: HTH; cl00088 545693004749 Integral membrane protein TerC family; Region: TerC; cl10468 545693004750 Coat F domain; Region: Coat_F; cl15836 545693004751 Heat induced stress protein YflT; Region: YflT; pfam11181 545693004752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693004753 PAS domain; Region: PAS_9; pfam13426 545693004754 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693004755 Helix-turn-helix domains; Region: HTH; cl00088 545693004756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 545693004757 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 545693004758 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693004759 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693004760 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693004761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004762 Helix-turn-helix domains; Region: HTH; cl00088 545693004763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693004764 dimerization interface [polypeptide binding]; other site 545693004765 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693004766 DNA-binding site [nucleotide binding]; DNA binding site 545693004767 RNA-binding motif; other site 545693004768 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693004769 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693004770 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693004771 ATP binding site [chemical binding]; other site 545693004772 Mg++ binding site [ion binding]; other site 545693004773 motif III; other site 545693004774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693004775 nucleotide binding region [chemical binding]; other site 545693004776 ATP-binding site [chemical binding]; other site 545693004777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693004778 DNA-binding site [nucleotide binding]; DNA binding site 545693004779 RNA-binding motif; other site 545693004780 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693004781 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693004782 acetolactate synthase; Reviewed; Region: PRK08322 545693004783 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693004784 PYR/PP interface [polypeptide binding]; other site 545693004785 dimer interface [polypeptide binding]; other site 545693004786 TPP binding site [chemical binding]; other site 545693004787 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693004788 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 545693004789 TPP-binding site [chemical binding]; other site 545693004790 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 545693004791 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693004792 Small acid-soluble spore protein H family; Region: SspH; cl06949 545693004793 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693004794 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 545693004795 substrate binding site [chemical binding]; other site 545693004796 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 545693004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004798 dimer interface [polypeptide binding]; other site 545693004799 conserved gate region; other site 545693004800 putative PBP binding loops; other site 545693004801 ABC-ATPase subunit interface; other site 545693004802 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 545693004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693004804 dimer interface [polypeptide binding]; other site 545693004805 conserved gate region; other site 545693004806 putative PBP binding loops; other site 545693004807 ABC-ATPase subunit interface; other site 545693004808 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693004809 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 545693004810 Walker A/P-loop; other site 545693004811 ATP binding site [chemical binding]; other site 545693004812 Q-loop/lid; other site 545693004813 ABC transporter signature motif; other site 545693004814 Walker B; other site 545693004815 D-loop; other site 545693004816 H-loop/switch region; other site 545693004817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693004818 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 545693004819 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693004820 Walker A/P-loop; other site 545693004821 ATP binding site [chemical binding]; other site 545693004822 Q-loop/lid; other site 545693004823 ABC transporter signature motif; other site 545693004824 Walker B; other site 545693004825 D-loop; other site 545693004826 H-loop/switch region; other site 545693004827 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 545693004828 MatE; Region: MatE; cl10513 545693004829 MatE; Region: MatE; cl10513 545693004830 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693004831 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693004832 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 545693004833 transcriptional regulator, GntR family protein, frameshift 545693004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004835 putative substrate translocation pore; other site 545693004836 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 545693004837 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693004838 putative peptidoglycan binding site; other site 545693004839 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693004840 putative peptidoglycan binding site; other site 545693004841 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 545693004842 active site 545693004843 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693004844 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 545693004845 active site 545693004846 catalytic residues [active] 545693004847 metal binding site [ion binding]; metal-binding site 545693004848 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 545693004849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693004850 Helix-turn-helix domains; Region: HTH; cl00088 545693004851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693004852 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693004853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693004854 S-adenosylmethionine binding site [chemical binding]; other site 545693004855 Helix-turn-helix domains; Region: HTH; cl00088 545693004856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693004857 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693004858 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693004859 putative active site [active] 545693004860 catalytic triad [active] 545693004861 putative dimer interface [polypeptide binding]; other site 545693004862 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 545693004863 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693004864 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 545693004865 Right handed beta helix region; Region: Beta_helix; pfam13229 545693004866 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 545693004867 protein RecA; Region: tigrfam_recA; TIGR02012 545693004868 hexamer interface [polypeptide binding]; other site 545693004869 Walker A motif; other site 545693004870 ATP binding site [chemical binding]; other site 545693004871 Walker B motif; other site 545693004872 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693004873 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 545693004874 active site 545693004875 arsenical pump membrane protein; Provisional; Region: PRK15445 545693004876 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693004877 transmembrane helices; other site 545693004878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693004879 dimerization interface [polypeptide binding]; other site 545693004880 putative DNA binding site [nucleotide binding]; other site 545693004881 putative Zn2+ binding site [ion binding]; other site 545693004882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693004883 dimerization interface [polypeptide binding]; other site 545693004884 putative DNA binding site [nucleotide binding]; other site 545693004885 putative Zn2+ binding site [ion binding]; other site 545693004886 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 545693004887 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693004888 putative metal binding site [ion binding]; other site 545693004889 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 545693004890 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693004891 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 545693004892 Ligand Binding Site [chemical binding]; other site 545693004893 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693004894 active site 545693004895 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 545693004896 Zn binding site [ion binding]; other site 545693004897 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 545693004898 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 545693004899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693004900 Helix-turn-helix domains; Region: HTH; cl00088 545693004901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693004902 dimerization interface [polypeptide binding]; other site 545693004903 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 545693004904 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 545693004905 active site 545693004906 FMN binding site [chemical binding]; other site 545693004907 substrate binding site [chemical binding]; other site 545693004908 putative catalytic residue [active] 545693004909 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693004910 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 545693004911 heme binding pocket [chemical binding]; other site 545693004912 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693004913 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693004914 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004915 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693004916 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 545693004917 Coat F domain; Region: Coat_F; cl15836 545693004918 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 545693004919 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693004920 NAD binding site [chemical binding]; other site 545693004921 catalytic Zn binding site [ion binding]; other site 545693004922 structural Zn binding site [ion binding]; other site 545693004923 Coat F domain; Region: Coat_F; cl15836 545693004924 Low molecular weight phosphatase family; Region: LMWPc; cl00105 545693004925 PAS domain; Region: PAS_9; pfam13426 545693004926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693004927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693004928 dimer interface [polypeptide binding]; other site 545693004929 phosphorylation site [posttranslational modification] 545693004930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693004931 ATP binding site [chemical binding]; other site 545693004932 Mg2+ binding site [ion binding]; other site 545693004933 G-X-G motif; other site 545693004934 Response regulator receiver domain; Region: Response_reg; pfam00072 545693004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004936 active site 545693004937 phosphorylation site [posttranslational modification] 545693004938 intermolecular recognition site; other site 545693004939 dimerization interface [polypeptide binding]; other site 545693004940 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 545693004941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 545693004942 putative ligand binding site [chemical binding]; other site 545693004943 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 545693004944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693004945 active site 545693004946 phosphorylation site [posttranslational modification] 545693004947 intermolecular recognition site; other site 545693004948 dimerization interface [polypeptide binding]; other site 545693004949 LytTr DNA-binding domain; Region: LytTR; cl04498 545693004950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693004951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693004952 DNA binding site [nucleotide binding] 545693004953 domain linker motif; other site 545693004954 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 545693004955 dimerization interface [polypeptide binding]; other site 545693004956 ligand binding site [chemical binding]; other site 545693004957 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 545693004958 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693004959 DNA interaction; other site 545693004960 Metal-binding active site; metal-binding site 545693004961 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693004962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004963 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693004964 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693004965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693004966 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693004967 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693004968 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693004969 polyol permease family; Region: 2A0118; TIGR00897 545693004970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693004971 putative substrate translocation pore; other site 545693004972 classical (c) SDRs; Region: SDR_c; cd05233 545693004973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693004974 NAD(P) binding site [chemical binding]; other site 545693004975 active site 545693004976 Major royal jelly protein; Region: MRJP; pfam03022 545693004977 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 545693004978 Phosphotransferase enzyme family; Region: APH; pfam01636 545693004979 putative active site [active] 545693004980 putative substrate binding site [chemical binding]; other site 545693004981 ATP binding site [chemical binding]; other site 545693004982 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693004983 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693004984 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 545693004985 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 545693004986 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 545693004987 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 545693004988 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 545693004989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693004990 S-adenosylmethionine binding site [chemical binding]; other site 545693004991 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693004992 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693004993 DNA binding residues [nucleotide binding] 545693004994 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693004995 DNA-binding site [nucleotide binding]; DNA binding site 545693004996 RNA-binding motif; other site 545693004997 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693004998 ZIP Zinc transporter; Region: Zip; pfam02535 545693004999 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693005000 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 545693005001 Sensory domain found in PocR; Region: PocR; pfam10114 545693005002 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 545693005003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693005004 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 545693005005 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 545693005006 dimer interface [polypeptide binding]; other site 545693005007 active site 545693005008 metal binding site [ion binding]; metal-binding site 545693005009 dihydroxyacetone kinase; Provisional; Region: PRK14479 545693005010 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 545693005011 DAK2 domain; Region: Dak2; cl03685 545693005012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693005013 Helix-turn-helix domains; Region: HTH; cl00088 545693005014 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693005015 classical (c) SDRs; Region: SDR_c; cd05233 545693005016 NAD(P) binding site [chemical binding]; other site 545693005017 active site 545693005018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005019 cyclohexanol reductases, including levodione reductase, classical (c) SDRs; Region: cyclohexanol_reductase_SDR_c; cd05330 545693005020 NAD binding site [chemical binding]; other site 545693005021 homotetramer interface [polypeptide binding]; other site 545693005022 homodimer interface [polypeptide binding]; other site 545693005023 active site 545693005024 substrate binding site [chemical binding]; other site 545693005025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005026 classical (c) SDRs; Region: SDR_c; cd05233 545693005027 NAD(P) binding site [chemical binding]; other site 545693005028 active site 545693005029 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 545693005030 Helix-turn-helix domains; Region: HTH; cl00088 545693005031 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 545693005032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693005033 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005034 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693005035 putative reverse transcriptase, point mutation 545693005036 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693005037 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693005038 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693005039 Cation transport protein; Region: TrkH; cl10514 545693005040 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693005041 Spore germination protein; Region: Spore_permease; cl15802 545693005042 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693005043 DNA-binding site [nucleotide binding]; DNA binding site 545693005044 RNA-binding motif; other site 545693005045 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 545693005046 active site 545693005047 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693005048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005049 DNA-binding site [nucleotide binding]; DNA binding site 545693005050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693005051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005052 homodimer interface [polypeptide binding]; other site 545693005053 catalytic residue [active] 545693005054 EamA-like transporter family; Region: EamA; cl01037 545693005055 EamA-like transporter family; Region: EamA; cl01037 545693005056 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693005057 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693005058 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693005060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005061 S-adenosylmethionine binding site [chemical binding]; other site 545693005062 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693005063 catalytic triad [active] 545693005064 conserved cis-peptide bond; other site 545693005065 Isochorismatase family; Region: Isochorismatase; pfam00857 545693005066 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693005067 catalytic triad [active] 545693005068 conserved cis-peptide bond; other site 545693005069 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 545693005070 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693005071 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 545693005072 DNA polymerase IV; Reviewed; Region: PRK03103 545693005073 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 545693005074 active site 545693005075 DNA binding site [nucleotide binding] 545693005076 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 545693005077 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693005078 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693005079 putative active site [active] 545693005080 putative NTP binding site [chemical binding]; other site 545693005081 putative nucleic acid binding site [nucleotide binding]; other site 545693005082 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 545693005083 active site 545693005084 YolD-like protein; Region: YolD; pfam08863 545693005085 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693005086 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 545693005087 phosphate binding motif [ion binding]; other site 545693005088 beta-alpha-beta structure motif; other site 545693005089 NAD binding pocket [chemical binding]; other site 545693005090 phosphoenolpyruvate synthase; Validated; Region: PRK06241 545693005091 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693005092 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 545693005093 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 545693005094 putative deacylase active site [active] 545693005095 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 545693005096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005097 putative substrate translocation pore; other site 545693005098 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 545693005099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693005100 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 545693005101 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693005102 tetrameric interface [polypeptide binding]; other site 545693005103 activator binding site; other site 545693005104 NADP binding site [chemical binding]; other site 545693005105 substrate binding site [chemical binding]; other site 545693005106 catalytic residues [active] 545693005107 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693005108 active site 545693005109 intersubunit interactions; other site 545693005110 catalytic residue [active] 545693005111 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779 545693005112 DinB superfamily; Region: DinB_2; pfam12867 545693005113 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 545693005114 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 545693005115 active site 545693005116 catalytic residues [active] 545693005117 FOG: CBS domain [General function prediction only]; Region: COG0517 545693005118 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 545693005119 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693005120 Cytochrome P450; Region: p450; pfam00067 545693005121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693005122 Helix-turn-helix domains; Region: HTH; cl00088 545693005123 Helix-turn-helix domains; Region: HTH; cl00088 545693005124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 545693005125 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 545693005126 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 545693005127 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 545693005128 N- and C-terminal domain interface [polypeptide binding]; other site 545693005129 D-xylulose kinase; Region: XylB; TIGR01312 545693005130 active site 545693005131 catalytic site [active] 545693005132 metal binding site [ion binding]; metal-binding site 545693005133 xylulose binding site [chemical binding]; other site 545693005134 putative ATP binding site [chemical binding]; other site 545693005135 homodimer interface [polypeptide binding]; other site 545693005136 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 545693005137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005138 putative substrate translocation pore; other site 545693005139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005140 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 545693005141 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 545693005142 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 545693005143 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693005144 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693005145 D-pathway; other site 545693005146 Putative ubiquinol binding site [chemical binding]; other site 545693005147 Low-spin heme (heme b) binding site [chemical binding]; other site 545693005148 Putative water exit pathway; other site 545693005149 Binuclear center (heme o3/CuB) [ion binding]; other site 545693005150 K-pathway; other site 545693005151 Putative proton exit pathway; other site 545693005152 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693005153 Subunit I/III interface [polypeptide binding]; other site 545693005154 Subunit III/IV interface [polypeptide binding]; other site 545693005155 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693005156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693005157 Ligand Binding Site [chemical binding]; other site 545693005158 oxidoreductase; Provisional; Region: PRK07985 545693005159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005160 NAD(P) binding site [chemical binding]; other site 545693005161 active site 545693005162 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 545693005163 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 545693005164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005165 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 545693005166 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 545693005167 transmembrane helices; other site 545693005168 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 545693005169 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693005170 tetramer interface [polypeptide binding]; other site 545693005171 TPP-binding site [chemical binding]; other site 545693005172 heterodimer interface [polypeptide binding]; other site 545693005173 phosphorylation loop region [posttranslational modification] 545693005174 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693005175 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693005176 alpha subunit interface [polypeptide binding]; other site 545693005177 TPP binding site [chemical binding]; other site 545693005178 heterodimer interface [polypeptide binding]; other site 545693005179 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693005180 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693005181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693005182 E3 interaction surface; other site 545693005183 lipoyl attachment site [posttranslational modification]; other site 545693005184 e3 binding domain; Region: E3_binding; pfam02817 545693005185 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 545693005186 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 545693005187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693005189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 545693005190 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 545693005191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693005192 Walker A motif; other site 545693005193 ATP binding site [chemical binding]; other site 545693005194 Walker B motif; other site 545693005195 arginine finger; other site 545693005196 Helix-turn-helix domains; Region: HTH; cl00088 545693005197 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693005198 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 545693005199 putative NAD(P) binding site [chemical binding]; other site 545693005200 catalytic Zn binding site [ion binding]; other site 545693005201 cystathionine gamma-synthase; Provisional; Region: PRK08249 545693005202 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693005203 homodimer interface [polypeptide binding]; other site 545693005204 substrate-cofactor binding pocket; other site 545693005205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005206 catalytic residue [active] 545693005207 transcriptional regulator Hpr; Provisional; Region: PRK13777 545693005208 Helix-turn-helix domains; Region: HTH; cl00088 545693005209 galactarate dehydratase; Region: galactar-dH20; TIGR03248 545693005210 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 545693005211 Propionate catabolism activator; Region: PrpR_N; pfam06506 545693005212 PAS domain S-box; Region: sensory_box; TIGR00229 545693005213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693005214 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693005215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693005216 Walker A motif; other site 545693005217 ATP binding site [chemical binding]; other site 545693005218 Walker B motif; other site 545693005219 arginine finger; other site 545693005220 Helix-turn-helix domains; Region: HTH; cl00088 545693005221 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 545693005222 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 545693005223 putative active site [active] 545693005224 catalytic residue [active] 545693005225 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 545693005226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693005227 NAD(P) binding site [chemical binding]; other site 545693005228 catalytic residues [active] 545693005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005230 D-galactonate transporter; Region: 2A0114; TIGR00893 545693005231 putative substrate translocation pore; other site 545693005232 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 545693005233 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 545693005234 active site 545693005235 tetramer interface [polypeptide binding]; other site 545693005236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693005237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005238 DNA-binding site [nucleotide binding]; DNA binding site 545693005239 FCD domain; Region: FCD; cl11656 545693005240 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693005241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693005242 active site 545693005243 metal binding site [ion binding]; metal-binding site 545693005244 Domain of unknown function DUF20; Region: UPF0118; pfam01594 545693005245 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 545693005246 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 545693005247 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 545693005248 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 545693005249 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 545693005250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005251 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 545693005252 putative substrate translocation pore; other site 545693005253 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 545693005254 CoA-transferase family III; Region: CoA_transf_3; pfam02515 545693005255 IDEAL domain; Region: IDEAL; cl07452 545693005256 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693005257 Ligand Binding Site [chemical binding]; other site 545693005258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693005259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693005260 dimerization interface [polypeptide binding]; other site 545693005261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005262 dimer interface [polypeptide binding]; other site 545693005263 phosphorylation site [posttranslational modification] 545693005264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005265 ATP binding site [chemical binding]; other site 545693005266 Mg2+ binding site [ion binding]; other site 545693005267 G-X-G motif; other site 545693005268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005270 active site 545693005271 phosphorylation site [posttranslational modification] 545693005272 intermolecular recognition site; other site 545693005273 dimerization interface [polypeptide binding]; other site 545693005274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693005275 DNA binding site [nucleotide binding] 545693005276 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 545693005277 putative homodimer interface [polypeptide binding]; other site 545693005278 putative homotetramer interface [polypeptide binding]; other site 545693005279 allosteric switch controlling residues; other site 545693005280 putative metal binding site [ion binding]; other site 545693005281 putative homodimer-homodimer interface [polypeptide binding]; other site 545693005282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005283 metal-binding site [ion binding] 545693005284 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005285 metal-binding site [ion binding] 545693005286 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693005287 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693005288 metal-binding site [ion binding] 545693005289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693005290 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693005291 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 545693005292 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 545693005293 D-galactonate transporter; Region: 2A0114; TIGR00893 545693005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005295 putative substrate translocation pore; other site 545693005296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 545693005297 catalytic loop [active] 545693005298 iron binding site [ion binding]; other site 545693005299 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693005300 YibE/F-like protein; Region: YibE_F; cl02259 545693005301 YibE/F-like protein; Region: YibE_F; cl02259 545693005302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005303 dimerization interface [polypeptide binding]; other site 545693005304 putative DNA binding site [nucleotide binding]; other site 545693005305 putative Zn2+ binding site [ion binding]; other site 545693005306 arsenical pump membrane protein; Provisional; Region: PRK15445 545693005307 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 545693005308 transmembrane helices; other site 545693005309 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 545693005310 active site 545693005311 metal binding site [ion binding]; metal-binding site 545693005312 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 545693005313 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693005314 catalytic core [active] 545693005315 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 545693005316 active site 545693005317 substrate binding site [chemical binding]; other site 545693005318 ATP binding site [chemical binding]; other site 545693005319 Transposase; Region: DEDD_Tnp_IS110; pfam01548 545693005320 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 545693005321 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 545693005322 putative active site [active] 545693005323 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 545693005324 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693005325 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005326 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693005327 SpoVA protein; Region: SpoVA; cl04298 545693005328 stage V sporulation protein AD; Provisional; Region: PRK12404 545693005329 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 545693005330 SpoVA protein; Region: SpoVA; cl04298 545693005331 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005332 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693005333 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 545693005334 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693005335 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 545693005336 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 545693005337 EamA-like transporter family; Region: EamA; cl01037 545693005338 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693005339 EamA-like transporter family; Region: EamA; cl01037 545693005340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693005341 Helix-turn-helix domains; Region: HTH; cl00088 545693005342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693005343 dimerization interface [polypeptide binding]; other site 545693005344 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 545693005345 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 545693005346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693005347 non-specific DNA binding site [nucleotide binding]; other site 545693005348 salt bridge; other site 545693005349 sequence-specific DNA binding site [nucleotide binding]; other site 545693005350 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 545693005351 DNA topoisomerase III; Provisional; Region: PRK07726 545693005352 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 545693005353 active site 545693005354 putative interdomain interaction site [polypeptide binding]; other site 545693005355 putative metal-binding site [ion binding]; other site 545693005356 putative nucleotide binding site [chemical binding]; other site 545693005357 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693005358 domain I; other site 545693005359 DNA binding groove [nucleotide binding] 545693005360 phosphate binding site [ion binding]; other site 545693005361 domain II; other site 545693005362 domain III; other site 545693005363 nucleotide binding site [chemical binding]; other site 545693005364 catalytic site [active] 545693005365 domain IV; other site 545693005366 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 545693005367 Uncharacterized conserved protein [Function unknown]; Region: COG5444 545693005368 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693005369 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693005370 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693005371 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 545693005372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005373 AAA domain; Region: AAA_21; pfam13304 545693005374 Walker A/P-loop; other site 545693005375 ATP binding site [chemical binding]; other site 545693005376 AAA domain; Region: AAA_21; pfam13304 545693005377 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 545693005378 domain IV; other site 545693005379 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 545693005380 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 545693005381 CoenzymeA binding site [chemical binding]; other site 545693005382 subunit interaction site [polypeptide binding]; other site 545693005383 PHB binding site; other site 545693005384 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 545693005385 nudix motif; other site 545693005386 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693005387 Tannase and feruloyl esterase; Region: Tannase; pfam07519 545693005388 Membrane transport protein; Region: Mem_trans; cl09117 545693005389 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693005390 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693005391 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693005392 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693005393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005394 DNA-binding site [nucleotide binding]; DNA binding site 545693005395 FCD domain; Region: FCD; cl11656 545693005396 tartrate dehydrogenase; Provisional; Region: PRK08194 545693005397 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 545693005398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693005400 putative substrate translocation pore; other site 545693005401 Helix-turn-helix domains; Region: HTH; cl00088 545693005402 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 545693005403 dimerization interface [polypeptide binding]; other site 545693005404 active site 545693005405 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 545693005406 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 545693005407 catalytic motif [active] 545693005408 Zn binding site [ion binding]; other site 545693005409 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 545693005410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693005411 non-specific DNA binding site [nucleotide binding]; other site 545693005412 salt bridge; other site 545693005413 sequence-specific DNA binding site [nucleotide binding]; other site 545693005414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693005415 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693005416 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 545693005417 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 545693005418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693005419 S-adenosylmethionine binding site [chemical binding]; other site 545693005420 Mor transcription activator family; Region: Mor; cl02360 545693005421 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 545693005422 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 545693005423 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 545693005424 active site residue [active] 545693005425 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 545693005426 active site residue [active] 545693005427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005428 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693005429 active site 545693005430 motif I; other site 545693005431 motif II; other site 545693005432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005433 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 545693005434 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 545693005435 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693005436 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 545693005437 NodB motif; other site 545693005438 active site 545693005439 catalytic site [active] 545693005440 metal binding site [ion binding]; metal-binding site 545693005441 Homoserine O-succinyltransferase; Region: HTS; pfam04204 545693005442 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 545693005443 proposed active site lysine [active] 545693005444 conserved cys residue [active] 545693005445 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 545693005446 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 545693005447 Potassium binding sites [ion binding]; other site 545693005448 Cesium cation binding sites [ion binding]; other site 545693005449 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 545693005450 catalytic residues [active] 545693005451 dimer interface [polypeptide binding]; other site 545693005452 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 545693005453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693005454 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 545693005455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005456 Walker A/P-loop; other site 545693005457 ATP binding site [chemical binding]; other site 545693005458 Q-loop/lid; other site 545693005459 ABC transporter signature motif; other site 545693005460 Walker B; other site 545693005461 D-loop; other site 545693005462 H-loop/switch region; other site 545693005463 ABC transporter; Region: ABC_tran_2; pfam12848 545693005464 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693005465 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 545693005466 Virulence factor; Region: Virulence_fact; pfam13769 545693005467 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 545693005468 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 545693005469 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 545693005470 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 545693005471 NodB motif; other site 545693005472 active site 545693005473 catalytic site [active] 545693005474 Zn binding site [ion binding]; other site 545693005475 Disulphide isomerase; Region: Disulph_isomer; pfam06491 545693005476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005477 YpjP-like protein; Region: YpjP; pfam14005 545693005478 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693005479 catalytic residues [active] 545693005480 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693005481 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 545693005482 putative binding site residues; other site 545693005483 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 545693005484 CobD/Cbib protein; Region: CobD_Cbib; cl00561 545693005485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693005486 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 545693005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693005488 homodimer interface [polypeptide binding]; other site 545693005489 catalytic residue [active] 545693005490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005491 Walker A motif; other site 545693005492 ATP binding site [chemical binding]; other site 545693005493 Walker B motif; other site 545693005494 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 545693005495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693005496 catalytic core [active] 545693005497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005498 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 545693005499 Predicted permeases [General function prediction only]; Region: RarD; COG2962 545693005500 EamA-like transporter family; Region: EamA; cl01037 545693005501 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693005502 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693005503 DNA binding residues [nucleotide binding] 545693005504 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 545693005505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005506 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 545693005507 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 545693005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005509 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 545693005510 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 545693005511 GIY-YIG motif/motif A; other site 545693005512 active site 545693005513 catalytic site [active] 545693005514 metal binding site [ion binding]; metal-binding site 545693005515 5'-3' exonuclease; Region: 53EXOc; smart00475 545693005516 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 545693005517 active site 545693005518 metal binding site 1 [ion binding]; metal-binding site 545693005519 putative 5' ssDNA interaction site; other site 545693005520 metal binding site 3; metal-binding site 545693005521 metal binding site 2 [ion binding]; metal-binding site 545693005522 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 545693005523 putative DNA binding site [nucleotide binding]; other site 545693005524 putative metal binding site [ion binding]; other site 545693005525 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 545693005526 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 545693005527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005528 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 545693005529 Protein of unknown function, DUF393; Region: DUF393; cl01136 545693005530 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 545693005531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693005532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693005533 DNA binding residues [nucleotide binding] 545693005534 putative anti-sigmaE protein; Provisional; Region: PRK13920 545693005535 Putative zinc-finger; Region: zf-HC2; cl15806 545693005536 Anti-sigma-K factor rskA; Region: RskA; pfam10099 545693005537 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693005538 putative dimer interface [polypeptide binding]; other site 545693005539 Replication terminator protein; Region: RTP; pfam02334 545693005540 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693005541 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693005542 multidrug efflux protein; Reviewed; Region: PRK01766 545693005543 MatE; Region: MatE; cl10513 545693005544 MatE; Region: MatE; cl10513 545693005545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693005546 classical (c) SDRs; Region: SDR_c; cd05233 545693005547 NAD(P) binding site [chemical binding]; other site 545693005548 active site 545693005549 phytoene desaturase; Region: crtI_fam; TIGR02734 545693005550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693005552 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 545693005553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693005554 active site 545693005555 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693005556 Sulfatase; Region: Sulfatase; cl10460 545693005557 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 545693005558 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 545693005559 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 545693005560 NodB motif; other site 545693005561 active site 545693005562 catalytic site [active] 545693005563 metal binding site [ion binding]; metal-binding site 545693005564 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 545693005565 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693005566 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693005567 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 545693005568 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 545693005569 putative integrin binding motif; other site 545693005570 PA/protease domain interface [polypeptide binding]; other site 545693005571 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 545693005572 metal binding site [ion binding]; metal-binding site 545693005573 sensory histidine kinase AtoS; Provisional; Region: PRK11360 545693005574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005575 dimer interface [polypeptide binding]; other site 545693005576 phosphorylation site [posttranslational modification] 545693005577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005578 ATP binding site [chemical binding]; other site 545693005579 Mg2+ binding site [ion binding]; other site 545693005580 G-X-G motif; other site 545693005581 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693005582 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693005583 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 545693005584 carbohydrate binding site [chemical binding]; other site 545693005585 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 545693005586 carbohydrate binding site [chemical binding]; other site 545693005587 pullulanase, type I; Region: pulA_typeI; TIGR02104 545693005588 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 545693005589 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 545693005590 Ca binding site [ion binding]; other site 545693005591 active site 545693005592 catalytic site [active] 545693005593 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 545693005594 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693005595 NAD(P) binding site [chemical binding]; other site 545693005596 catalytic residues [active] 545693005597 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693005598 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693005599 active site 545693005600 substrate binding site [chemical binding]; other site 545693005601 ATP binding site [chemical binding]; other site 545693005602 flagellar motor protein MotA; Validated; Region: PRK08124 545693005603 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 545693005604 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 545693005605 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 545693005606 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 545693005607 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 545693005608 ligand binding site [chemical binding]; other site 545693005609 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 545693005610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005611 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 545693005612 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 545693005613 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 545693005614 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 545693005615 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 545693005616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693005617 DNA-binding site [nucleotide binding]; DNA binding site 545693005618 FCD domain; Region: FCD; cl11656 545693005619 S-methylmethionine transporter; Provisional; Region: PRK11387 545693005620 OpgC protein; Region: OpgC_C; cl00792 545693005621 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693005622 SurA N-terminal domain; Region: SurA_N_3; cl07813 545693005623 PPIC-type PPIASE domain; Region: Rotamase; cl08278 545693005624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005626 active site 545693005627 phosphorylation site [posttranslational modification] 545693005628 intermolecular recognition site; other site 545693005629 dimerization interface [polypeptide binding]; other site 545693005630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693005631 DNA binding site [nucleotide binding] 545693005632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005633 dimer interface [polypeptide binding]; other site 545693005634 phosphorylation site [posttranslational modification] 545693005635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693005636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005637 ATP binding site [chemical binding]; other site 545693005638 Mg2+ binding site [ion binding]; other site 545693005639 G-X-G motif; other site 545693005640 allantoinase; Provisional; Region: PRK06189 545693005641 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 545693005642 active site 545693005643 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 545693005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005645 putative substrate translocation pore; other site 545693005646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 545693005647 malate dehydrogenase; Provisional; Region: PRK13529 545693005648 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693005649 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693005650 NAD(P) binding site [chemical binding]; other site 545693005651 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 545693005652 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693005653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005654 motif II; other site 545693005655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693005656 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693005657 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 545693005658 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005659 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 545693005660 catalytic residues [active] 545693005661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693005662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693005663 substrate binding pocket [chemical binding]; other site 545693005664 membrane-bound complex binding site; other site 545693005665 hinge residues; other site 545693005666 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693005667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005668 dimer interface [polypeptide binding]; other site 545693005669 conserved gate region; other site 545693005670 putative PBP binding loops; other site 545693005671 ABC-ATPase subunit interface; other site 545693005672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005673 dimer interface [polypeptide binding]; other site 545693005674 conserved gate region; other site 545693005675 putative PBP binding loops; other site 545693005676 ABC-ATPase subunit interface; other site 545693005677 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693005678 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 545693005679 Walker A/P-loop; other site 545693005680 ATP binding site [chemical binding]; other site 545693005681 Q-loop/lid; other site 545693005682 ABC transporter signature motif; other site 545693005683 Walker B; other site 545693005684 D-loop; other site 545693005685 H-loop/switch region; other site 545693005686 Riboflavin kinase; Region: Flavokinase; cl03312 545693005687 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693005688 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 545693005689 active site 545693005690 non-prolyl cis peptide bond; other site 545693005691 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693005692 active site 545693005693 metal binding site [ion binding]; metal-binding site 545693005694 Cupin domain; Region: Cupin_2; cl09118 545693005695 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 545693005696 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 545693005697 amidase catalytic site [active] 545693005698 Zn binding residues [ion binding]; other site 545693005699 substrate binding site [chemical binding]; other site 545693005700 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005701 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 545693005702 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693005703 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 545693005704 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 545693005705 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693005706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005707 NAD(P) binding pocket [chemical binding]; other site 545693005708 Bacterial PH domain; Region: DUF304; cl01348 545693005709 Predicted membrane protein [Function unknown]; Region: COG3428 545693005710 Bacterial PH domain; Region: DUF304; cl01348 545693005711 Bacterial PH domain; Region: DUF304; cl01348 545693005712 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 545693005713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693005714 catalytic residue [active] 545693005715 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693005716 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 545693005717 putative substrate binding site [chemical binding]; other site 545693005718 putative ATP binding site [chemical binding]; other site 545693005719 UbiA prenyltransferase family; Region: UbiA; cl00337 545693005720 Protein of unknown function (DUF867); Region: DUF867; cl01713 545693005721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005722 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693005723 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693005724 DNA binding residues [nucleotide binding] 545693005725 Small acid-soluble spore protein H family; Region: SspH; cl06949 545693005726 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 545693005727 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 545693005728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693005729 Helix-turn-helix domains; Region: HTH; cl00088 545693005730 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693005731 putative dimerization interface [polypeptide binding]; other site 545693005732 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 545693005733 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 545693005734 active site 545693005735 dimer interface [polypeptide binding]; other site 545693005736 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 545693005737 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 545693005738 active site 545693005739 FMN binding site [chemical binding]; other site 545693005740 substrate binding site [chemical binding]; other site 545693005741 3Fe-4S cluster binding site [ion binding]; other site 545693005742 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 545693005743 domain interface; other site 545693005744 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 545693005745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005746 Staygreen protein; Region: Staygreen; pfam12638 545693005747 Tannase and feruloyl esterase; Region: Tannase; pfam07519 545693005748 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 545693005749 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 545693005750 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 545693005751 homodimer interface [polypeptide binding]; other site 545693005752 NADP binding site [chemical binding]; other site 545693005753 substrate binding site [chemical binding]; other site 545693005754 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693005755 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693005756 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 545693005757 PLD-like domain; Region: PLDc_2; pfam13091 545693005758 putative active site [active] 545693005759 catalytic site [active] 545693005760 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 545693005761 PLD-like domain; Region: PLDc_2; pfam13091 545693005762 putative active site [active] 545693005763 catalytic site [active] 545693005764 Predicted acetyltransferase [General function prediction only]; Region: COG3981 545693005765 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693005767 Helix-turn-helix domains; Region: HTH; cl00088 545693005768 LrgA family; Region: LrgA; cl00608 545693005769 LrgB-like family; Region: LrgB; cl00596 545693005770 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693005771 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693005772 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005773 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 545693005774 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 545693005775 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 545693005776 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 545693005777 Ligand binding site; other site 545693005778 Putative Catalytic site; other site 545693005779 DXD motif; other site 545693005780 GtrA-like protein; Region: GtrA; cl00971 545693005781 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693005782 active site 545693005783 tetramer interface; other site 545693005784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693005785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693005786 active site 545693005787 phosphorylation site [posttranslational modification] 545693005788 intermolecular recognition site; other site 545693005789 dimerization interface [polypeptide binding]; other site 545693005790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693005791 DNA binding site [nucleotide binding] 545693005792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693005793 dimerization interface [polypeptide binding]; other site 545693005794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693005795 dimer interface [polypeptide binding]; other site 545693005796 phosphorylation site [posttranslational modification] 545693005797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693005798 ATP binding site [chemical binding]; other site 545693005799 Mg2+ binding site [ion binding]; other site 545693005800 G-X-G motif; other site 545693005801 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 545693005802 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693005803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693005804 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 545693005805 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 545693005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005807 dimer interface [polypeptide binding]; other site 545693005808 conserved gate region; other site 545693005809 putative PBP binding loops; other site 545693005810 ABC-ATPase subunit interface; other site 545693005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693005812 dimer interface [polypeptide binding]; other site 545693005813 conserved gate region; other site 545693005814 putative PBP binding loops; other site 545693005815 ABC-ATPase subunit interface; other site 545693005816 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 545693005817 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 545693005818 Walker A/P-loop; other site 545693005819 ATP binding site [chemical binding]; other site 545693005820 Q-loop/lid; other site 545693005821 ABC transporter signature motif; other site 545693005822 Walker B; other site 545693005823 D-loop; other site 545693005824 H-loop/switch region; other site 545693005825 TOBE-like domain; Region: TOBE_3; pfam12857 545693005826 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 545693005827 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693005828 dimer interface [polypeptide binding]; other site 545693005829 active site 545693005830 CoA binding pocket [chemical binding]; other site 545693005831 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693005832 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693005833 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693005834 YolD-like protein; Region: YolD; pfam08863 545693005835 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693005836 Helix-turn-helix domains; Region: HTH; cl00088 545693005837 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693005838 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 545693005839 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 545693005840 putative substrate binding site [chemical binding]; other site 545693005841 putative ATP binding site [chemical binding]; other site 545693005842 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 545693005843 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693005844 active site 545693005845 phosphorylation site [posttranslational modification] 545693005846 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 545693005847 active site 545693005848 P-loop; other site 545693005849 phosphorylation site [posttranslational modification] 545693005850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693005851 aspartate kinase; Reviewed; Region: PRK09034 545693005852 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 545693005853 putative catalytic residues [active] 545693005854 putative nucleotide binding site [chemical binding]; other site 545693005855 putative aspartate binding site [chemical binding]; other site 545693005856 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 545693005857 allosteric regulatory residue; other site 545693005858 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 545693005859 YusW-like protein; Region: YusW; pfam14039 545693005860 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 545693005861 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 545693005862 E-class dimer interface [polypeptide binding]; other site 545693005863 P-class dimer interface [polypeptide binding]; other site 545693005864 active site 545693005865 Cu2+ binding site [ion binding]; other site 545693005866 Zn2+ binding site [ion binding]; other site 545693005867 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 545693005868 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693005869 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693005870 DNA binding residues [nucleotide binding] 545693005871 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693005872 classical (c) SDRs; Region: SDR_c; cd05233 545693005873 NAD(P) binding site [chemical binding]; other site 545693005874 active site 545693005875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693005876 dimerization interface [polypeptide binding]; other site 545693005877 putative DNA binding site [nucleotide binding]; other site 545693005878 putative Zn2+ binding site [ion binding]; other site 545693005879 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 545693005880 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 545693005881 NAD(P) binding site [chemical binding]; other site 545693005882 catalytic residues [active] 545693005883 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 545693005884 TspO/MBR family; Region: TspO_MBR; cl01379 545693005885 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 545693005886 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693005887 putative peptidoglycan binding site; other site 545693005888 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693005889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693005890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693005891 DNA binding site [nucleotide binding] 545693005892 domain linker motif; other site 545693005893 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693005894 dimerization interface [polypeptide binding]; other site 545693005895 ligand binding site [chemical binding]; other site 545693005896 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 545693005897 conserved cys residue [active] 545693005898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693005899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693005901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693005902 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693005903 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693005904 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693005905 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 545693005906 DNA interaction; other site 545693005907 Metal-binding active site; metal-binding site 545693005908 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693005909 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 545693005910 active site 545693005911 DNA binding site [nucleotide binding] 545693005912 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 545693005913 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693005914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693005915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693005916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693005917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693005918 Coenzyme A binding pocket [chemical binding]; other site 545693005919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693005920 Helix-turn-helix domains; Region: HTH; cl00088 545693005921 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 545693005922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693005923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693005924 putative substrate translocation pore; other site 545693005925 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 545693005926 substrate binding site [chemical binding]; other site 545693005927 multimerization interface [polypeptide binding]; other site 545693005928 ATP binding site [chemical binding]; other site 545693005929 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 545693005930 thiamine phosphate binding site [chemical binding]; other site 545693005931 active site 545693005932 pyrophosphate binding site [ion binding]; other site 545693005933 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 545693005934 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693005935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693005936 non-specific DNA binding site [nucleotide binding]; other site 545693005937 salt bridge; other site 545693005938 sequence-specific DNA binding site [nucleotide binding]; other site 545693005939 Putative zinc-finger; Region: zf-HC2; cl15806 545693005940 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 545693005941 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 545693005942 RNA polymerase sigma factor; Provisional; Region: PRK12541 545693005943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693005944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693005945 DNA binding residues [nucleotide binding] 545693005946 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 545693005947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693005948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693005949 Walker A motif; other site 545693005950 Walker A motif; other site 545693005951 ATP binding site [chemical binding]; other site 545693005952 Walker B motif; other site 545693005953 arginine finger; other site 545693005954 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 545693005955 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 545693005956 metal ion-dependent adhesion site (MIDAS); other site 545693005957 EamA-like transporter family; Region: EamA; cl01037 545693005958 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693005959 EamA-like transporter family; Region: EamA; cl01037 545693005960 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 545693005961 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 545693005962 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 545693005963 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 545693005964 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 545693005965 Cupin domain; Region: Cupin_2; cl09118 545693005966 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693005967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693005968 RIP metalloprotease RseP; Region: TIGR00054 545693005969 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 545693005970 active site 545693005971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693005972 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005973 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693005974 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 545693005975 Walker A/P-loop; other site 545693005976 ATP binding site [chemical binding]; other site 545693005977 Q-loop/lid; other site 545693005978 ABC transporter signature motif; other site 545693005979 Walker B; other site 545693005980 D-loop; other site 545693005981 H-loop/switch region; other site 545693005982 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693005983 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693005984 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 545693005985 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 545693005986 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 545693005987 active site 545693005988 putative carbohydrate kinase; Provisional; Region: PRK10565 545693005989 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 545693005990 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 545693005991 putative substrate binding site [chemical binding]; other site 545693005992 putative ATP binding site [chemical binding]; other site 545693005993 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 545693005994 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 545693005995 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693005996 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693005997 Helix-turn-helix domains; Region: HTH; cl00088 545693005998 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693005999 C-terminal domain interface [polypeptide binding]; other site 545693006000 sugar binding site [chemical binding]; other site 545693006001 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693006002 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693006003 classical (c) SDRs; Region: SDR_c; cd05233 545693006004 NAD(P) binding site [chemical binding]; other site 545693006005 active site 545693006006 ribosomal RNA adenine dimethylase, point mutation 545693006007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693006008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693006009 active site 545693006010 phosphorylation site [posttranslational modification] 545693006011 intermolecular recognition site; other site 545693006012 dimerization interface [polypeptide binding]; other site 545693006013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693006014 DNA binding site [nucleotide binding] 545693006015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693006016 dimerization interface [polypeptide binding]; other site 545693006017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006018 dimer interface [polypeptide binding]; other site 545693006019 phosphorylation site [posttranslational modification] 545693006020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006021 ATP binding site [chemical binding]; other site 545693006022 Mg2+ binding site [ion binding]; other site 545693006023 G-X-G motif; other site 545693006024 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693006025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006026 DNA-binding site [nucleotide binding]; DNA binding site 545693006027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006029 homodimer interface [polypeptide binding]; other site 545693006030 catalytic residue [active] 545693006031 LysE type translocator; Region: LysE; cl00565 545693006032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693006033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693006034 active site 545693006035 metal binding site [ion binding]; metal-binding site 545693006036 DinB superfamily; Region: DinB_2; pfam12867 545693006037 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693006038 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 545693006039 Helix-turn-helix domains; Region: HTH; cl00088 545693006040 Anti-repressor SinI; Region: SinI; pfam08671 545693006041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693006042 non-specific DNA binding site [nucleotide binding]; other site 545693006043 salt bridge; other site 545693006044 sequence-specific DNA binding site [nucleotide binding]; other site 545693006045 Anti-repressor SinI; Region: SinI; pfam08671 545693006046 hypothetical protein; Provisional; Region: PRK06185 545693006047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 545693006049 nudix motif; other site 545693006050 Isochorismatase family; Region: Isochorismatase; pfam00857 545693006051 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693006052 catalytic triad [active] 545693006053 conserved cis-peptide bond; other site 545693006054 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 545693006055 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 545693006056 active site 545693006057 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 545693006058 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 545693006059 active site 545693006060 (T/H)XGH motif; other site 545693006061 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 545693006062 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 545693006063 homodimer interface [polypeptide binding]; other site 545693006064 NAD binding pocket [chemical binding]; other site 545693006065 ATP binding pocket [chemical binding]; other site 545693006066 Mg binding site [ion binding]; other site 545693006067 active-site loop [active] 545693006068 hypothetical protein; Provisional; Region: PRK08582 545693006069 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 545693006070 RNA binding site [nucleotide binding]; other site 545693006071 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 545693006072 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 545693006073 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693006074 putative active site [active] 545693006075 catalytic triad [active] 545693006076 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 545693006077 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693006078 FlgD Ig-like domain; Region: FlgD_ig; cl15790 545693006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006080 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 545693006081 NAD(P) binding site [chemical binding]; other site 545693006082 active site 545693006083 Acylphosphatase; Region: Acylphosphatase; cl00551 545693006084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693006086 putative substrate translocation pore; other site 545693006087 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 545693006088 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693006089 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693006090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693006091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693006092 EamA-like transporter family; Region: EamA; cl01037 545693006093 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693006094 EamA-like transporter family; Region: EamA; cl01037 545693006095 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 545693006096 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693006097 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693006098 ABC transporter; Region: ABC_tran_2; pfam12848 545693006099 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693006100 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693006101 Spore germination protein; Region: Spore_permease; cl15802 545693006102 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693006103 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 545693006104 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693006105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693006106 Walker A/P-loop; other site 545693006107 ATP binding site [chemical binding]; other site 545693006108 Q-loop/lid; other site 545693006109 ABC transporter signature motif; other site 545693006110 Walker B; other site 545693006111 D-loop; other site 545693006112 H-loop/switch region; other site 545693006113 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693006114 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 545693006115 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693006116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693006117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693006118 DNA binding site [nucleotide binding] 545693006119 domain linker motif; other site 545693006120 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 545693006121 putative dimerization interface [polypeptide binding]; other site 545693006122 putative ligand binding site [chemical binding]; other site 545693006123 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 545693006124 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 545693006125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693006126 FeS/SAM binding site; other site 545693006127 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 545693006128 DNA topoisomerase III; Provisional; Region: PRK07726 545693006129 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 545693006130 active site 545693006131 putative interdomain interaction site [polypeptide binding]; other site 545693006132 putative metal-binding site [ion binding]; other site 545693006133 putative nucleotide binding site [chemical binding]; other site 545693006134 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693006135 domain I; other site 545693006136 DNA binding groove [nucleotide binding] 545693006137 phosphate binding site [ion binding]; other site 545693006138 domain II; other site 545693006139 domain III; other site 545693006140 nucleotide binding site [chemical binding]; other site 545693006141 catalytic site [active] 545693006142 domain IV; other site 545693006143 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 545693006144 Regulatory protein YrvL; Region: YrvL; pfam14184 545693006145 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 545693006146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693006147 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 545693006148 Spore germination protein; Region: Spore_permease; cl15802 545693006149 Spore germination protein; Region: Spore_permease; cl15802 545693006150 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 545693006151 putative active site [active] 545693006152 catalytic site [active] 545693006153 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 545693006154 PLD-like domain; Region: PLDc_2; pfam13091 545693006155 putative active site [active] 545693006156 catalytic site [active] 545693006157 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 545693006158 Spore germination protein; Region: Spore_permease; cl15802 545693006159 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693006160 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693006161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693006162 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693006163 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 545693006164 VanW like protein; Region: VanW; pfam04294 545693006165 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693006166 DNA binding residues [nucleotide binding] 545693006167 Predicted membrane protein [Function unknown]; Region: COG1289 545693006168 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 545693006169 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693006170 Heat induced stress protein YflT; Region: YflT; pfam11181 545693006171 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 545693006172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693006173 ATP binding site [chemical binding]; other site 545693006174 putative Mg++ binding site [ion binding]; other site 545693006175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693006176 nucleotide binding region [chemical binding]; other site 545693006177 ATP-binding site [chemical binding]; other site 545693006178 RQC domain; Region: RQC; cl09632 545693006179 HRDC domain; Region: HRDC; cl02578 545693006180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 545693006181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006182 putative active site [active] 545693006183 heme pocket [chemical binding]; other site 545693006184 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 545693006185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693006186 Walker A motif; other site 545693006187 ATP binding site [chemical binding]; other site 545693006188 Walker B motif; other site 545693006189 arginine finger; other site 545693006190 Helix-turn-helix domains; Region: HTH; cl00088 545693006191 Arginase family; Region: Arginase; cl00306 545693006192 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693006193 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 545693006194 NAD(P) binding site [chemical binding]; other site 545693006195 catalytic residues [active] 545693006196 Sodium:solute symporter family; Region: SSF; cl00456 545693006197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693006198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693006199 nucleotide binding region [chemical binding]; other site 545693006200 ATP-binding site [chemical binding]; other site 545693006201 UbiA prenyltransferase family; Region: UbiA; cl00337 545693006202 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 545693006203 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 545693006204 Predicted membrane protein [Function unknown]; Region: COG1511 545693006205 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693006206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693006207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006208 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 545693006209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693006211 putative substrate translocation pore; other site 545693006212 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 545693006213 Helix-turn-helix domains; Region: HTH; cl00088 545693006214 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 545693006215 putative dimerization interface [polypeptide binding]; other site 545693006216 Predicted transcriptional regulators [Transcription]; Region: COG1725 545693006217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006218 DNA-binding site [nucleotide binding]; DNA binding site 545693006219 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693006220 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693006221 Walker A/P-loop; other site 545693006222 ATP binding site [chemical binding]; other site 545693006223 Q-loop/lid; other site 545693006224 ABC transporter signature motif; other site 545693006225 Walker B; other site 545693006226 D-loop; other site 545693006227 H-loop/switch region; other site 545693006228 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693006229 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693006230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693006231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693006232 DNA binding residues [nucleotide binding] 545693006233 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 545693006234 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693006235 DNA polymerase IV; Validated; Region: PRK01810 545693006236 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 545693006237 active site 545693006238 DNA binding site [nucleotide binding] 545693006239 OsmC-like protein; Region: OsmC; cl00767 545693006240 Helix-turn-helix domains; Region: HTH; cl00088 545693006241 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693006242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693006243 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 545693006244 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693006245 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693006246 putative peptidoglycan binding site; other site 545693006247 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693006248 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693006249 putative peptidoglycan binding site; other site 545693006250 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693006251 putative peptidoglycan binding site; other site 545693006252 3D domain; Region: 3D; cl01439 545693006253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693006254 Family description; Region: UvrD_C_2; cl15862 545693006255 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 545693006256 putative active site [active] 545693006257 catalytic site [active] 545693006258 B12 binding domain; Region: B12-binding_2; cl03653 545693006259 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 545693006260 B12 binding site [chemical binding]; other site 545693006261 CheB methylesterase; Region: CheB_methylest; pfam01339 545693006262 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 545693006263 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693006264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006265 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 545693006266 Protein of unknown function (DUF904); Region: DUF904; cl11531 545693006267 PAS domain; Region: PAS_10; pfam13596 545693006268 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693006269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006270 putative active site [active] 545693006271 heme pocket [chemical binding]; other site 545693006272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006273 dimer interface [polypeptide binding]; other site 545693006274 phosphorylation site [posttranslational modification] 545693006275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006276 ATP binding site [chemical binding]; other site 545693006277 Mg2+ binding site [ion binding]; other site 545693006278 G-X-G motif; other site 545693006279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006280 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 545693006281 gamma-glutamyl kinase; Provisional; Region: PRK13402 545693006282 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 545693006283 nucleotide binding site [chemical binding]; other site 545693006284 homotetrameric interface [polypeptide binding]; other site 545693006285 putative phosphate binding site [ion binding]; other site 545693006286 putative allosteric binding site; other site 545693006287 PUA domain; Region: PUA; cl00607 545693006288 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 545693006289 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 545693006290 putative catalytic cysteine [active] 545693006291 Cold-inducible protein YdjO; Region: YdjO; pfam14169 545693006292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693006293 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 545693006294 dimer interface [polypeptide binding]; other site 545693006295 putative metal binding site [ion binding]; other site 545693006296 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 545693006297 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 545693006298 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 545693006299 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 545693006300 Amidinotransferase; Region: Amidinotransf; cl12043 545693006301 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693006302 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 545693006303 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 545693006304 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693006305 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 545693006306 substrate binding pocket [chemical binding]; other site 545693006307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693006308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693006309 binding surface 545693006310 TPR motif; other site 545693006311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693006312 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 545693006313 oligomeric interface; other site 545693006314 putative active site [active] 545693006315 homodimer interface [polypeptide binding]; other site 545693006316 maltose O-acetyltransferase; Provisional; Region: PRK10092 545693006317 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 545693006318 active site 545693006319 substrate binding site [chemical binding]; other site 545693006320 trimer interface [polypeptide binding]; other site 545693006321 CoA binding site [chemical binding]; other site 545693006322 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693006323 Zn binding site [ion binding]; other site 545693006324 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693006325 Zn binding site [ion binding]; other site 545693006326 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 545693006327 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693006328 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 545693006329 Sodium:solute symporter family; Region: SSF; cl00456 545693006330 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693006331 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693006332 active site 545693006333 catalytic site [active] 545693006334 substrate binding site [chemical binding]; other site 545693006335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 545693006336 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 545693006337 fumarate hydratase class II, frameshift 545693006338 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 545693006339 active site 545693006340 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693006341 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693006342 two-component sensor histidine kinase, frameshift 545693006343 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 545693006344 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 545693006345 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693006346 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 545693006347 active site 545693006348 Zn binding site [ion binding]; other site 545693006349 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693006350 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693006351 active site 545693006352 metal binding site [ion binding]; metal-binding site 545693006353 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693006354 active site 545693006355 intersubunit interactions; other site 545693006356 catalytic residue [active] 545693006357 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693006358 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 545693006359 dimer interface [polypeptide binding]; other site 545693006360 FMN binding site [chemical binding]; other site 545693006361 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 545693006362 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 545693006363 classical (c) SDRs; Region: SDR_c; cd05233 545693006364 NAD(P) binding site [chemical binding]; other site 545693006365 active site 545693006366 Citrate transporter; Region: CitMHS; pfam03600 545693006367 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693006368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006369 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 545693006370 NAD(P) binding site [chemical binding]; other site 545693006371 active site 545693006372 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 545693006373 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 545693006374 metal binding site [ion binding]; metal-binding site 545693006375 dimer interface [polypeptide binding]; other site 545693006376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006377 Coenzyme A binding pocket [chemical binding]; other site 545693006378 Helix-turn-helix domains; Region: HTH; cl00088 545693006379 U5 snRNP spliceosome subunit [RNA processing and modification]; Region: PRP8; COG5178 545693006380 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 545693006381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693006382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693006383 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 545693006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006385 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693006386 Helix-turn-helix domains; Region: HTH; cl00088 545693006387 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693006388 putative dimerization interface [polypeptide binding]; other site 545693006389 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693006390 diaminopimelate decarboxylase; Region: lysA; TIGR01048 545693006391 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 545693006392 active site 545693006393 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693006394 substrate binding site [chemical binding]; other site 545693006395 catalytic residues [active] 545693006396 dimer interface [polypeptide binding]; other site 545693006397 FAD dependent oxidoreductase; Region: DAO; pfam01266 545693006398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006399 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 545693006400 PAS domain S-box; Region: sensory_box; TIGR00229 545693006401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006402 putative active site [active] 545693006403 heme pocket [chemical binding]; other site 545693006404 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693006405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693006406 putative active site [active] 545693006407 heme pocket [chemical binding]; other site 545693006408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006409 dimer interface [polypeptide binding]; other site 545693006410 phosphorylation site [posttranslational modification] 545693006411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006412 ATP binding site [chemical binding]; other site 545693006413 Mg2+ binding site [ion binding]; other site 545693006414 G-X-G motif; other site 545693006415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693006416 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 545693006417 FAD binding site [chemical binding]; other site 545693006418 substrate binding site [chemical binding]; other site 545693006419 catalytic base [active] 545693006420 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 545693006421 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 545693006422 NADP binding site [chemical binding]; other site 545693006423 homodimer interface [polypeptide binding]; other site 545693006424 active site 545693006425 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 545693006426 AMP-binding enzyme; Region: AMP-binding; cl15778 545693006427 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693006428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693006429 Helix-turn-helix domains; Region: HTH; cl00088 545693006430 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 545693006431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693006433 enoyl-CoA hydratase; Provisional; Region: PRK06688 545693006434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693006435 substrate binding site [chemical binding]; other site 545693006436 oxyanion hole (OAH) forming residues; other site 545693006437 trimer interface [polypeptide binding]; other site 545693006438 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693006439 active site 545693006440 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 545693006441 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 545693006442 putative active site [active] 545693006443 putative substrate binding site [chemical binding]; other site 545693006444 ATP binding site [chemical binding]; other site 545693006445 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 545693006446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693006447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693006448 active site 545693006449 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693006450 classical (c) SDRs; Region: SDR_c; cd05233 545693006451 NAD(P) binding site [chemical binding]; other site 545693006452 active site 545693006453 enoyl-CoA hydratase; Provisional; Region: PRK06688 545693006454 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693006455 substrate binding site [chemical binding]; other site 545693006456 oxyanion hole (OAH) forming residues; other site 545693006457 trimer interface [polypeptide binding]; other site 545693006458 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693006459 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 545693006460 NADP binding site [chemical binding]; other site 545693006461 dimer interface [polypeptide binding]; other site 545693006462 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 545693006463 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 545693006464 active site 545693006465 multimer interface [polypeptide binding]; other site 545693006466 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 545693006467 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 545693006468 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693006469 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693006470 putative acyltransferase; Provisional; Region: PRK05790 545693006471 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693006472 dimer interface [polypeptide binding]; other site 545693006473 active site 545693006474 hypothetical protein; Provisional; Region: PRK06917 545693006475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693006476 inhibitor-cofactor binding pocket; inhibition site 545693006477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006478 catalytic residue [active] 545693006479 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 545693006480 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693006481 inhibitor-cofactor binding pocket; inhibition site 545693006482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006483 catalytic residue [active] 545693006484 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 545693006485 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693006486 NAD(P) binding site [chemical binding]; other site 545693006487 catalytic residues [active] 545693006488 Uncharacterized conserved protein [Function unknown]; Region: COG5476 545693006489 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 545693006490 MlrC C-terminus; Region: MlrC_C; pfam07171 545693006491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006492 putative acetyltransferase YhhY; Provisional; Region: PRK10140 545693006493 Coenzyme A binding pocket [chemical binding]; other site 545693006494 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 545693006495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693006496 FeS/SAM binding site; other site 545693006497 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 545693006498 YokU-like protein; Region: YokU; cl15819 545693006499 lysine transporter; Provisional; Region: PRK10836 545693006500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693006501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693006502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006503 Coenzyme A binding pocket [chemical binding]; other site 545693006504 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 545693006505 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693006506 dimer interface [polypeptide binding]; other site 545693006507 active site 545693006508 metal binding site [ion binding]; metal-binding site 545693006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006510 putative substrate translocation pore; other site 545693006511 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 545693006512 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693006513 Prephenate dehydratase; Region: PDT; pfam00800 545693006514 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 545693006515 EamA-like transporter family; Region: EamA; cl01037 545693006516 EamA-like transporter family; Region: EamA; cl01037 545693006517 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 545693006518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006520 homodimer interface [polypeptide binding]; other site 545693006521 catalytic residue [active] 545693006522 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693006523 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 545693006524 active site 545693006525 dimer interface [polypeptide binding]; other site 545693006526 motif 1; other site 545693006527 motif 2; other site 545693006528 motif 3; other site 545693006529 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 545693006530 anticodon binding site; other site 545693006531 amino acid transporter; Region: 2A0306; TIGR00909 545693006532 Spore germination protein; Region: Spore_permease; cl15802 545693006533 Spore germination protein; Region: Spore_permease; cl15802 545693006534 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693006535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006536 putative substrate translocation pore; other site 545693006537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006538 Helix-turn-helix domains; Region: HTH; cl00088 545693006539 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 545693006540 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 545693006541 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 545693006542 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 545693006543 Walker A/P-loop; other site 545693006544 ATP binding site [chemical binding]; other site 545693006545 Q-loop/lid; other site 545693006546 ABC transporter signature motif; other site 545693006547 Walker B; other site 545693006548 D-loop; other site 545693006549 H-loop/switch region; other site 545693006550 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 545693006551 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 545693006552 putative active site [active] 545693006553 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 545693006554 dimer interface [polypeptide binding]; other site 545693006555 active site 545693006556 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693006557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006559 dimer interface [polypeptide binding]; other site 545693006560 conserved gate region; other site 545693006561 putative PBP binding loops; other site 545693006562 ABC-ATPase subunit interface; other site 545693006563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693006564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693006565 dimer interface [polypeptide binding]; other site 545693006566 conserved gate region; other site 545693006567 putative PBP binding loops; other site 545693006568 ABC-ATPase subunit interface; other site 545693006569 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 545693006570 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693006571 substrate binding site [chemical binding]; other site 545693006572 ATP binding site [chemical binding]; other site 545693006573 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 545693006574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006575 DNA-binding site [nucleotide binding]; DNA binding site 545693006576 UTRA domain; Region: UTRA; cl01230 545693006577 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693006578 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 545693006579 putative hydrophobic ligand binding site [chemical binding]; other site 545693006580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693006581 dimerization interface [polypeptide binding]; other site 545693006582 putative DNA binding site [nucleotide binding]; other site 545693006583 putative Zn2+ binding site [ion binding]; other site 545693006584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693006585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693006586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693006587 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 545693006588 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 545693006589 active site residue [active] 545693006590 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 545693006591 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 545693006592 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 545693006593 apolar tunnel; other site 545693006594 heme binding site [chemical binding]; other site 545693006595 dimerization interface [polypeptide binding]; other site 545693006596 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 545693006597 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 545693006598 Protein of unknown function (DUF817); Region: DUF817; cl01520 545693006599 heat shock protein 90; Provisional; Region: PRK05218 545693006600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 545693006601 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 545693006602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006603 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 545693006604 L-serine binding site [chemical binding]; other site 545693006605 ACT domain interface; other site 545693006606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693006607 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 545693006608 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693006609 active site 545693006610 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 545693006611 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693006612 EamA-like transporter family; Region: EamA; cl01037 545693006613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693006614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693006615 DNA-binding site [nucleotide binding]; DNA binding site 545693006616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006618 homodimer interface [polypeptide binding]; other site 545693006619 catalytic residue [active] 545693006620 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 545693006621 ChaB; Region: ChaB; cl01887 545693006622 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 545693006623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693006624 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693006625 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 545693006626 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 545693006627 NAD(P) binding site [chemical binding]; other site 545693006628 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 545693006629 putative FMN binding site [chemical binding]; other site 545693006630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693006631 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693006632 Walker A/P-loop; other site 545693006633 ATP binding site [chemical binding]; other site 545693006634 Q-loop/lid; other site 545693006635 ABC transporter signature motif; other site 545693006636 Walker B; other site 545693006637 D-loop; other site 545693006638 H-loop/switch region; other site 545693006639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693006640 FtsX-like permease family; Region: FtsX; cl15850 545693006641 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 545693006642 FtsX-like permease family; Region: FtsX; cl15850 545693006643 transglutaminase; Provisional; Region: tgl; PRK03187 545693006644 DinB superfamily; Region: DinB_2; pfam12867 545693006645 Domain of unknown function (DUF378); Region: DUF378; cl00943 545693006646 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 545693006647 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 545693006648 cobalamin binding residues [chemical binding]; other site 545693006649 putative BtuC binding residues; other site 545693006650 dimer interface [polypeptide binding]; other site 545693006651 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693006652 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 545693006653 putative active site [active] 545693006654 putative CoA binding site [chemical binding]; other site 545693006655 nudix motif; other site 545693006656 metal binding site [ion binding]; metal-binding site 545693006657 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 545693006658 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693006659 NAD(P) binding site [chemical binding]; other site 545693006660 putative active site [active] 545693006661 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 545693006662 AMP-binding enzyme; Region: AMP-binding; cl15778 545693006663 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693006664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006665 Helix-turn-helix domains; Region: HTH; cl00088 545693006666 VanW like protein; Region: VanW; pfam04294 545693006667 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 545693006668 AMP-binding enzyme; Region: AMP-binding; cl15778 545693006669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693006670 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 545693006671 active site 545693006672 catalytic site [active] 545693006673 substrate binding site [chemical binding]; other site 545693006674 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 545693006675 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 545693006676 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 545693006677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693006678 catalytic residue [active] 545693006679 Scramblase; Region: Scramblase; cl02043 545693006680 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 545693006681 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 545693006682 G1 box; other site 545693006683 putative GEF interaction site [polypeptide binding]; other site 545693006684 GTP/Mg2+ binding site [chemical binding]; other site 545693006685 Switch I region; other site 545693006686 G2 box; other site 545693006687 G3 box; other site 545693006688 Switch II region; other site 545693006689 G4 box; other site 545693006690 G5 box; other site 545693006691 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 545693006692 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 545693006693 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 545693006694 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 545693006695 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693006696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006697 putative substrate translocation pore; other site 545693006698 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693006699 FAD binding domain; Region: FAD_binding_4; pfam01565 545693006700 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 545693006701 Cache domain; Region: Cache_1; pfam02743 545693006702 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 545693006703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693006704 dimerization interface [polypeptide binding]; other site 545693006705 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 545693006706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 545693006707 dimer interface [polypeptide binding]; other site 545693006708 putative CheW interface [polypeptide binding]; other site 545693006709 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 545693006710 active site 545693006711 metal binding site [ion binding]; metal-binding site 545693006712 homotetramer interface [polypeptide binding]; other site 545693006713 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693006714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693006715 putative active site [active] 545693006716 putative metal binding site [ion binding]; other site 545693006717 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 545693006718 active site 545693006719 SUMO-1 interface [polypeptide binding]; other site 545693006720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 545693006721 NlpC/P60 family; Region: NLPC_P60; cl11438 545693006722 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 545693006723 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 545693006724 active site 545693006725 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693006726 Helix-turn-helix domains; Region: HTH; cl00088 545693006727 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693006728 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 545693006729 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693006730 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693006731 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 545693006732 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 545693006733 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693006734 carboxyltransferase (CT) interaction site; other site 545693006735 biotinylation site [posttranslational modification]; other site 545693006736 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 545693006737 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 545693006738 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 545693006739 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 545693006740 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 545693006741 LamB/YcsF family; Region: LamB_YcsF; cl00664 545693006742 trehalose synthase; Region: treS_nterm; TIGR02456 545693006743 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 545693006744 Ca binding site [ion binding]; other site 545693006745 active site 545693006746 catalytic site [active] 545693006747 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 545693006748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006749 Coenzyme A binding pocket [chemical binding]; other site 545693006750 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 545693006751 AMP-binding enzyme; Region: AMP-binding; cl15778 545693006752 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693006753 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 545693006754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693006755 dimer interface [polypeptide binding]; other site 545693006756 active site 545693006757 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693006758 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 545693006759 Uncharacterized conserved protein [Function unknown]; Region: COG4715 545693006760 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 545693006761 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 545693006762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693006763 ATP binding site [chemical binding]; other site 545693006764 putative Mg++ binding site [ion binding]; other site 545693006765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693006766 nucleotide binding region [chemical binding]; other site 545693006767 ATP-binding site [chemical binding]; other site 545693006768 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006770 putative substrate translocation pore; other site 545693006771 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693006772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693006773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693006774 active site 545693006775 phosphorylation site [posttranslational modification] 545693006776 intermolecular recognition site; other site 545693006777 dimerization interface [polypeptide binding]; other site 545693006778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693006779 DNA binding residues [nucleotide binding] 545693006780 dimerization interface [polypeptide binding]; other site 545693006781 GAF domain; Region: GAF_2; pfam13185 545693006782 GAF domain; Region: GAF; cl15785 545693006783 Histidine kinase; Region: HisKA_3; pfam07730 545693006784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006785 ATP binding site [chemical binding]; other site 545693006786 Mg2+ binding site [ion binding]; other site 545693006787 G-X-G motif; other site 545693006788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693006789 non-specific DNA binding site [nucleotide binding]; other site 545693006790 salt bridge; other site 545693006791 sequence-specific DNA binding site [nucleotide binding]; other site 545693006792 Cupin domain; Region: Cupin_2; cl09118 545693006793 EamA-like transporter family; Region: EamA; cl01037 545693006794 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 545693006795 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 545693006796 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693006797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006798 Coenzyme A binding pocket [chemical binding]; other site 545693006799 Dehydratase family; Region: ILVD_EDD; cl00340 545693006800 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 545693006801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693006802 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 545693006803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 545693006804 DHHA2 domain; Region: DHHA2; pfam02833 545693006805 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 545693006806 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 545693006807 homodimer interface [polypeptide binding]; other site 545693006808 substrate-cofactor binding pocket; other site 545693006809 catalytic residue [active] 545693006810 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693006811 putative acyl-acceptor binding pocket; other site 545693006812 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 545693006813 xanthine permease; Region: pbuX; TIGR03173 545693006814 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 545693006815 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 545693006816 active site 545693006817 homotetramer interface [polypeptide binding]; other site 545693006818 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693006819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006820 Coenzyme A binding pocket [chemical binding]; other site 545693006821 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 545693006822 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 545693006823 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 545693006824 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 545693006825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693006826 motif II; other site 545693006827 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006828 Helix-turn-helix domains; Region: HTH; cl00088 545693006829 Helix-turn-helix domains; Region: HTH; cl00088 545693006830 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 545693006831 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693006832 active site 545693006833 DNA binding site [nucleotide binding] 545693006834 Int/Topo IB signature motif; other site 545693006835 ethanolamine permease; Region: 2A0305; TIGR00908 545693006836 Spore germination protein; Region: Spore_permease; cl15802 545693006837 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 545693006838 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 545693006839 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 545693006840 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 545693006841 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693006842 lysine transporter; Provisional; Region: PRK10836 545693006843 Spore germination protein; Region: Spore_permease; cl15802 545693006844 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 545693006845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006846 Coenzyme A binding pocket [chemical binding]; other site 545693006847 Isochorismatase family; Region: Isochorismatase; pfam00857 545693006848 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693006849 catalytic triad [active] 545693006850 conserved cis-peptide bond; other site 545693006851 Cupin domain; Region: Cupin_2; cl09118 545693006852 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 545693006853 LysE type translocator; Region: LysE; cl00565 545693006854 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693006855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693006856 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 545693006857 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 545693006858 CAP-like domain; other site 545693006859 active site 545693006860 primary dimer interface [polypeptide binding]; other site 545693006861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693006862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693006863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 545693006864 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 545693006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006866 ATP binding site [chemical binding]; other site 545693006867 Mg2+ binding site [ion binding]; other site 545693006868 G-X-G motif; other site 545693006869 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 545693006870 anchoring element; other site 545693006871 dimer interface [polypeptide binding]; other site 545693006872 ATP binding site [chemical binding]; other site 545693006873 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 545693006874 active site 545693006875 putative metal-binding site [ion binding]; other site 545693006876 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 545693006877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006878 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 545693006879 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 545693006880 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693006881 active site 545693006882 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 545693006883 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 545693006884 putative active site [active] 545693006885 putative catalytic site [active] 545693006886 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 545693006887 putative catalytic site [active] 545693006888 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 545693006889 Small acid-soluble spore protein N family; Region: SspN; cl11659 545693006890 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 545693006891 catalytic residues [active] 545693006892 aconitate hydratase; Validated; Region: PRK09277 545693006893 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 545693006894 substrate binding site [chemical binding]; other site 545693006895 ligand binding site [chemical binding]; other site 545693006896 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 545693006897 substrate binding site [chemical binding]; other site 545693006898 Small acid-soluble spore protein O family; Region: SspO; cl07943 545693006899 Small acid-soluble spore protein P family; Region: SspP; cl12105 545693006900 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693006901 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693006902 putative dimer interface [polypeptide binding]; other site 545693006903 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 545693006904 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 545693006905 putative DNA binding site [nucleotide binding]; other site 545693006906 putative homodimer interface [polypeptide binding]; other site 545693006907 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 545693006908 Protein of unknown function (DUF524); Region: DUF524; pfam04411 545693006909 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 545693006910 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 545693006911 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 545693006912 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 545693006913 catalytic loop [active] 545693006914 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 545693006915 iron binding site [ion binding]; other site 545693006916 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 545693006917 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 545693006918 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 545693006919 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 545693006920 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 545693006921 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 545693006922 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 545693006923 Ligand binding site; other site 545693006924 metal-binding site 545693006925 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 545693006926 XdhC Rossmann domain; Region: XdhC_C; pfam13478 545693006927 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693006928 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693006929 putative dimer interface [polypeptide binding]; other site 545693006930 Helix-turn-helix domains; Region: HTH; cl00088 545693006931 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 545693006932 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693006933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693006934 hypothetical protein; Provisional; Region: PRK09272 545693006935 Helix-turn-helix domains; Region: HTH; cl00088 545693006936 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693006937 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693006938 Predicted transcriptional regulators [Transcription]; Region: COG1378 545693006939 Helix-turn-helix domains; Region: HTH; cl00088 545693006940 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693006941 C-terminal domain interface [polypeptide binding]; other site 545693006942 sugar binding site [chemical binding]; other site 545693006943 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006945 putative substrate translocation pore; other site 545693006946 Protein of unknown function (DUF523); Region: DUF523; cl00733 545693006947 Asp23 family; Region: Asp23; cl00574 545693006948 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 545693006949 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 545693006950 Domain of unknown function (DUF202); Region: DUF202; cl09954 545693006951 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 545693006952 drug efflux system protein MdtG; Provisional; Region: PRK09874 545693006953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006954 putative substrate translocation pore; other site 545693006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693006956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693006957 putative substrate translocation pore; other site 545693006958 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693006959 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693006960 DNA binding residues [nucleotide binding] 545693006961 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 545693006962 active site clefts [active] 545693006963 zinc binding site [ion binding]; other site 545693006964 dimer interface [polypeptide binding]; other site 545693006965 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693006966 putative transporter; Provisional; Region: PRK11660 545693006967 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693006968 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 545693006969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693006971 active site 545693006972 phosphorylation site [posttranslational modification] 545693006973 intermolecular recognition site; other site 545693006974 dimerization interface [polypeptide binding]; other site 545693006975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693006976 DNA binding site [nucleotide binding] 545693006977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693006978 dimerization interface [polypeptide binding]; other site 545693006979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693006980 dimer interface [polypeptide binding]; other site 545693006981 phosphorylation site [posttranslational modification] 545693006982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693006983 ATP binding site [chemical binding]; other site 545693006984 Mg2+ binding site [ion binding]; other site 545693006985 G-X-G motif; other site 545693006986 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 545693006987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693006988 Coenzyme A binding pocket [chemical binding]; other site 545693006989 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693006990 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693006991 amino acid transporter; Region: 2A0306; TIGR00909 545693006992 RQC domain; Region: RQC; cl09632 545693006993 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 545693006994 stage II sporulation protein P; Region: spore_II_P; TIGR02867 545693006995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693006996 Walker A motif; other site 545693006997 ATP binding site [chemical binding]; other site 545693006998 Walker B motif; other site 545693006999 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 545693007000 putative FMN binding site [chemical binding]; other site 545693007001 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693007002 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693007003 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 545693007004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007005 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 545693007006 catalytic triad [active] 545693007007 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 545693007008 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 545693007009 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 545693007010 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 545693007011 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693007012 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693007013 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693007014 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693007015 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693007016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693007017 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 545693007018 CbiD; Region: CbiD; cl00828 545693007019 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 545693007020 Precorrin-8X methylmutase; Region: CbiC; pfam02570 545693007021 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 545693007022 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 545693007023 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 545693007024 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 545693007025 putative active site [active] 545693007026 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 545693007027 putative active site [active] 545693007028 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693007029 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693007030 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 545693007031 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 545693007032 dimer interface [polypeptide binding]; other site 545693007033 [2Fe-2S] cluster binding site [ion binding]; other site 545693007034 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 545693007035 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 545693007036 putative oligomer interface [polypeptide binding]; other site 545693007037 putative active site [active] 545693007038 metal binding site [ion binding]; metal-binding site 545693007039 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693007040 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693007041 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 545693007042 IDEAL domain; Region: IDEAL; cl07452 545693007043 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 545693007044 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 545693007045 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693007046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693007047 Membrane transport protein; Region: Mem_trans; cl09117 545693007048 malate dehydrogenase; Provisional; Region: PRK13529 545693007049 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693007050 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693007051 NAD(P) binding site [chemical binding]; other site 545693007052 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 545693007053 amidohydrolase; Region: amidohydrolases; TIGR01891 545693007054 putative metal binding site [ion binding]; other site 545693007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007056 D-galactonate transporter; Region: 2A0114; TIGR00893 545693007057 putative substrate translocation pore; other site 545693007058 GAF domain; Region: GAF_2; pfam13185 545693007059 GAF domain; Region: GAF; cl15785 545693007060 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007061 Helix-turn-helix domains; Region: HTH; cl00088 545693007062 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 545693007063 aromatic acid decarboxylase; Validated; Region: PRK05920 545693007064 Flavoprotein; Region: Flavoprotein; cl08021 545693007065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693007066 Helix-turn-helix domains; Region: HTH; cl00088 545693007067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693007068 dimerization interface [polypeptide binding]; other site 545693007069 Membrane transport protein; Region: Mem_trans; cl09117 545693007070 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 545693007071 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693007072 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 545693007073 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693007074 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 545693007075 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 545693007076 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693007077 Cysteine-rich domain; Region: CCG; pfam02754 545693007078 Cysteine-rich domain; Region: CCG; pfam02754 545693007079 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007080 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 545693007081 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007082 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 545693007083 Helix-turn-helix domains; Region: HTH; cl00088 545693007084 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 545693007085 intracellular protease, PfpI family; Region: PfpI; TIGR01382 545693007086 conserved cys residue [active] 545693007087 IDEAL domain; Region: IDEAL; cl07452 545693007088 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693007089 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693007090 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 545693007091 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 545693007092 putative active site [active] 545693007093 metal binding site [ion binding]; metal-binding site 545693007094 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693007095 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693007096 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 545693007097 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693007098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007099 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 545693007100 Walker A/P-loop; other site 545693007101 ATP binding site [chemical binding]; other site 545693007102 Q-loop/lid; other site 545693007103 ABC transporter signature motif; other site 545693007104 Walker B; other site 545693007105 D-loop; other site 545693007106 H-loop/switch region; other site 545693007107 Histidine kinase; Region: HisKA_3; pfam07730 545693007108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 545693007109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693007110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007111 active site 545693007112 phosphorylation site [posttranslational modification] 545693007113 intermolecular recognition site; other site 545693007114 dimerization interface [polypeptide binding]; other site 545693007115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693007116 DNA binding residues [nucleotide binding] 545693007117 dimerization interface [polypeptide binding]; other site 545693007118 allantoate amidohydrolase; Reviewed; Region: PRK09290 545693007119 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 545693007120 active site 545693007121 metal binding site [ion binding]; metal-binding site 545693007122 dimer interface [polypeptide binding]; other site 545693007123 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 545693007124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007125 Coenzyme A binding pocket [chemical binding]; other site 545693007126 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693007127 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693007128 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 545693007129 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 545693007130 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 545693007131 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693007132 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 545693007133 Active_site [active] 545693007134 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693007135 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 545693007136 active site 545693007137 catalytic site [active] 545693007138 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693007139 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693007140 active site 545693007141 catalytic triad [active] 545693007142 dimer interface [polypeptide binding]; other site 545693007143 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693007144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693007145 Walker A motif; other site 545693007146 ATP binding site [chemical binding]; other site 545693007147 Walker B motif; other site 545693007148 arginine finger; other site 545693007149 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693007150 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 545693007151 active site 545693007152 catalytic triad [active] 545693007153 dimer interface [polypeptide binding]; other site 545693007154 amino acid transporter; Region: 2A0306; TIGR00909 545693007155 Spore germination protein; Region: Spore_permease; cl15802 545693007156 Spore germination protein; Region: Spore_permease; cl15802 545693007157 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693007158 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693007159 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693007160 Protein of unknown function, DUF600; Region: DUF600; cl04640 545693007161 Protein of unknown function, DUF600; Region: DUF600; cl04640 545693007162 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 545693007163 GAD-like domain; Region: GAD-like; pfam08887 545693007164 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 545693007165 Uncharacterized conserved protein [Function unknown]; Region: COG5444 545693007166 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 545693007167 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 545693007168 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 545693007169 MatE; Region: MatE; cl10513 545693007170 MatE; Region: MatE; cl10513 545693007171 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 545693007172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007173 putative substrate translocation pore; other site 545693007174 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693007175 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693007176 Helix-turn-helix domains; Region: HTH; cl00088 545693007177 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 545693007178 active site 545693007179 putative catalytic site [active] 545693007180 DNA binding site [nucleotide binding] 545693007181 putative phosphate binding site [ion binding]; other site 545693007182 metal binding site A [ion binding]; metal-binding site 545693007183 AP binding site [nucleotide binding]; other site 545693007184 metal binding site B [ion binding]; metal-binding site 545693007185 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 545693007186 Erythromycin esterase; Region: Erythro_esteras; pfam05139 545693007187 Domain of unknown function (DUF336); Region: DUF336; cl01249 545693007188 putative oxidoreductase; Provisional; Region: PRK11579 545693007189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007190 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693007191 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693007192 Helix-turn-helix domains; Region: HTH; cl00088 545693007193 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693007194 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 545693007195 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 545693007196 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 545693007197 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007198 putative metal binding site [ion binding]; other site 545693007199 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 545693007200 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007201 putative metal binding site [ion binding]; other site 545693007202 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 545693007203 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 545693007204 putative metal binding site [ion binding]; other site 545693007205 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 545693007206 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 545693007207 active site 545693007208 metal binding site [ion binding]; metal-binding site 545693007209 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 545693007210 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 545693007211 putative active site [active] 545693007212 putative metal binding site [ion binding]; other site 545693007213 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 545693007214 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693007215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693007216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007217 Walker A/P-loop; other site 545693007218 ATP binding site [chemical binding]; other site 545693007219 Q-loop/lid; other site 545693007220 ABC transporter signature motif; other site 545693007221 Walker B; other site 545693007222 D-loop; other site 545693007223 H-loop/switch region; other site 545693007224 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 545693007225 active site 545693007226 catalytic triad [active] 545693007227 oxyanion hole [active] 545693007228 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693007229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007230 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693007231 DNA-binding site [nucleotide binding]; DNA binding site 545693007232 RNA-binding motif; other site 545693007233 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693007234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007235 DNA-binding site [nucleotide binding]; DNA binding site 545693007236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693007237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693007238 homodimer interface [polypeptide binding]; other site 545693007239 catalytic residue [active] 545693007240 pyruvate oxidase; Provisional; Region: PRK08611 545693007241 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 545693007242 PYR/PP interface [polypeptide binding]; other site 545693007243 dimer interface [polypeptide binding]; other site 545693007244 tetramer interface [polypeptide binding]; other site 545693007245 TPP binding site [chemical binding]; other site 545693007246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693007247 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 545693007248 TPP-binding site [chemical binding]; other site 545693007249 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693007250 DNA-binding site [nucleotide binding]; DNA binding site 545693007251 RNA-binding motif; other site 545693007252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693007253 classical (c) SDRs; Region: SDR_c; cd05233 545693007254 NAD(P) binding site [chemical binding]; other site 545693007255 active site 545693007256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693007257 classical (c) SDRs; Region: SDR_c; cd05233 545693007258 NAD(P) binding site [chemical binding]; other site 545693007259 active site 545693007260 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693007261 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 545693007262 NADP binding site [chemical binding]; other site 545693007263 dimer interface [polypeptide binding]; other site 545693007264 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 545693007265 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 545693007266 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693007267 LytTr DNA-binding domain; Region: LytTR; cl04498 545693007268 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693007269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693007270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007271 putative substrate translocation pore; other site 545693007272 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693007273 putative peptidoglycan binding site; other site 545693007274 3D domain; Region: 3D; cl01439 545693007275 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 545693007276 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 545693007277 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 545693007278 Cupin domain; Region: Cupin_2; cl09118 545693007279 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693007280 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693007281 active site 545693007282 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 545693007283 NADPH bind site [chemical binding]; other site 545693007284 putative FMN binding site [chemical binding]; other site 545693007285 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 545693007286 putative FMN binding site [chemical binding]; other site 545693007287 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 545693007288 YcaO-like family; Region: YcaO; pfam02624 545693007289 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 545693007290 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 545693007291 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 545693007292 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 545693007293 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 545693007294 HIGH motif; other site 545693007295 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 545693007296 active site 545693007297 KMSKS motif; other site 545693007298 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 545693007299 tRNA binding surface [nucleotide binding]; other site 545693007300 anticodon binding site; other site 545693007301 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 545693007302 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 545693007303 GIY-YIG motif/motif A; other site 545693007304 putative active site [active] 545693007305 putative metal binding site [ion binding]; other site 545693007306 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 545693007307 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 545693007308 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 545693007309 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 545693007310 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 545693007311 active site 545693007312 nucleophile elbow; other site 545693007313 Phosphotransferase enzyme family; Region: APH; pfam01636 545693007314 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693007315 active site 545693007316 substrate binding site [chemical binding]; other site 545693007317 ATP binding site [chemical binding]; other site 545693007318 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 545693007319 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693007320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007321 Predicted dehydrogenase [General function prediction only]; Region: COG0579 545693007322 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 545693007323 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693007324 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 545693007325 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 545693007326 GDYXXLXY protein; Region: GDYXXLXY; cl02066 545693007327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 545693007328 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693007329 ABC transporter; Region: ABC_tran_2; pfam12848 545693007330 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 545693007331 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 545693007332 alpha-galactosidase; Provisional; Region: PRK15076 545693007333 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 545693007334 NAD binding site [chemical binding]; other site 545693007335 sugar binding site [chemical binding]; other site 545693007336 divalent metal binding site [ion binding]; other site 545693007337 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693007338 dimer interface [polypeptide binding]; other site 545693007339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693007340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007341 dimer interface [polypeptide binding]; other site 545693007342 conserved gate region; other site 545693007343 putative PBP binding loops; other site 545693007344 ABC-ATPase subunit interface; other site 545693007345 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 545693007346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007347 dimer interface [polypeptide binding]; other site 545693007348 conserved gate region; other site 545693007349 putative PBP binding loops; other site 545693007350 ABC-ATPase subunit interface; other site 545693007351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693007352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693007353 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 545693007354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693007355 DNA binding site [nucleotide binding] 545693007356 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 545693007357 putative dimerization interface [polypeptide binding]; other site 545693007358 putative ligand binding site [chemical binding]; other site 545693007359 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 545693007360 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693007361 Glycerate kinase family; Region: Gly_kinase; cl00841 545693007362 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 545693007363 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693007364 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693007365 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 545693007366 Helix-turn-helix domains; Region: HTH; cl00088 545693007367 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 545693007368 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 545693007369 active site 545693007370 NAD binding site [chemical binding]; other site 545693007371 metal binding site [ion binding]; metal-binding site 545693007372 Protein of unknown function (DUF805); Region: DUF805; cl01224 545693007373 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693007374 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693007375 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693007376 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 545693007377 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 545693007378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693007379 substrate binding pocket [chemical binding]; other site 545693007380 membrane-bound complex binding site; other site 545693007381 hinge residues; other site 545693007382 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 545693007383 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 545693007384 Protein of unknown function (DUF805); Region: DUF805; cl01224 545693007385 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 545693007386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007387 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693007388 putative substrate translocation pore; other site 545693007389 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 545693007390 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 545693007391 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693007392 Nucleoside recognition; Region: Gate; cl00486 545693007393 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693007394 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 545693007395 active site 545693007396 catalytic motif [active] 545693007397 Zn binding site [ion binding]; other site 545693007398 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 545693007399 intersubunit interface [polypeptide binding]; other site 545693007400 active site 545693007401 catalytic residue [active] 545693007402 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 545693007403 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693007404 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693007405 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 545693007406 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 545693007407 Helix-turn-helix domains; Region: HTH; cl00088 545693007408 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 545693007409 Uncharacterized conserved protein [Function unknown]; Region: COG4997 545693007410 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 545693007411 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 545693007412 active site 545693007413 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 545693007414 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 545693007415 Helix-turn-helix domains; Region: HTH; cl00088 545693007416 Peptidase family M48; Region: Peptidase_M48; cl12018 545693007417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693007418 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 545693007419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693007420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693007421 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693007422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007423 dimer interface [polypeptide binding]; other site 545693007424 conserved gate region; other site 545693007425 putative PBP binding loops; other site 545693007426 ABC-ATPase subunit interface; other site 545693007427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007428 dimer interface [polypeptide binding]; other site 545693007429 conserved gate region; other site 545693007430 putative PBP binding loops; other site 545693007431 ABC-ATPase subunit interface; other site 545693007432 short chain dehydrogenase; Provisional; Region: PRK06197 545693007433 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 545693007434 putative NAD(P) binding site [chemical binding]; other site 545693007435 active site 545693007436 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693007437 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693007438 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 545693007439 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 545693007440 putative active site [active] 545693007441 putative metal binding site [ion binding]; other site 545693007442 putative inner membrane protein; Provisional; Region: PRK11099 545693007443 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693007444 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 545693007445 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693007446 dimer interface [polypeptide binding]; other site 545693007447 active site 545693007448 metal binding site [ion binding]; metal-binding site 545693007449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693007450 Helix-turn-helix domains; Region: HTH; cl00088 545693007451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693007452 dimerization interface [polypeptide binding]; other site 545693007453 EamA-like transporter family; Region: EamA; cl01037 545693007454 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693007455 EamA-like transporter family; Region: EamA; cl01037 545693007456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007457 Coenzyme A binding pocket [chemical binding]; other site 545693007458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007459 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693007460 putative substrate translocation pore; other site 545693007461 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693007462 active site 545693007463 metal binding site [ion binding]; metal-binding site 545693007464 topology modulation protein; Reviewed; Region: PRK08118 545693007465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007466 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 545693007467 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 545693007468 NADP binding site [chemical binding]; other site 545693007469 homodimer interface [polypeptide binding]; other site 545693007470 active site 545693007471 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007473 NAD(P) binding site [chemical binding]; other site 545693007474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007475 DNA-binding site [nucleotide binding]; DNA binding site 545693007476 FCD domain; Region: FCD; cl11656 545693007477 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693007478 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 545693007479 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 545693007480 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693007481 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693007482 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693007483 Transporter associated domain; Region: CorC_HlyC; cl08393 545693007484 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 545693007485 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 545693007486 topology modulation protein; Reviewed; Region: PRK08118 545693007487 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 545693007488 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693007489 Walker A/P-loop; other site 545693007490 ATP binding site [chemical binding]; other site 545693007491 Q-loop/lid; other site 545693007492 ABC transporter signature motif; other site 545693007493 Walker B; other site 545693007494 D-loop; other site 545693007495 H-loop/switch region; other site 545693007496 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693007497 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 545693007498 Walker A/P-loop; other site 545693007499 ATP binding site [chemical binding]; other site 545693007500 Q-loop/lid; other site 545693007501 ABC transporter signature motif; other site 545693007502 Walker B; other site 545693007503 D-loop; other site 545693007504 H-loop/switch region; other site 545693007505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693007506 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 545693007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007508 dimer interface [polypeptide binding]; other site 545693007509 conserved gate region; other site 545693007510 putative PBP binding loops; other site 545693007511 ABC-ATPase subunit interface; other site 545693007512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693007513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693007514 dimer interface [polypeptide binding]; other site 545693007515 conserved gate region; other site 545693007516 putative PBP binding loops; other site 545693007517 ABC-ATPase subunit interface; other site 545693007518 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 545693007519 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 545693007520 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 545693007521 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693007522 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693007523 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693007524 Tetratricopeptide repeat; Region: TPR_12; pfam13424 545693007525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693007526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007527 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693007528 Coenzyme A binding pocket [chemical binding]; other site 545693007529 Staphylococcal nuclease homologues; Region: SNc; smart00318 545693007530 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 545693007531 Catalytic site; other site 545693007532 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 545693007533 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 545693007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007535 Predicted dehydrogenase [General function prediction only]; Region: COG0579 545693007536 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 545693007537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693007538 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693007539 active site 545693007540 motif I; other site 545693007541 motif II; other site 545693007542 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693007543 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693007544 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 545693007545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693007546 active site 545693007547 motif I; other site 545693007548 motif II; other site 545693007549 Uncharacterized conserved protein [Function unknown]; Region: COG4278 545693007550 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 545693007551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693007552 Helix-turn-helix domains; Region: HTH; cl00088 545693007553 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693007554 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 545693007555 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 545693007556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693007557 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 545693007558 active site 545693007559 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007560 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 545693007561 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693007562 Cysteine-rich domain; Region: CCG; pfam02754 545693007563 Cysteine-rich domain; Region: CCG; pfam02754 545693007564 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693007565 FAD binding domain; Region: FAD_binding_4; pfam01565 545693007566 glycolate transporter; Provisional; Region: PRK09695 545693007567 L-lactate permease; Region: Lactate_perm; cl00701 545693007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007569 D-galactonate transporter; Region: 2A0114; TIGR00893 545693007570 putative substrate translocation pore; other site 545693007571 Predicted amidohydrolase [General function prediction only]; Region: COG0388 545693007572 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 545693007573 putative active site [active] 545693007574 catalytic triad [active] 545693007575 putative dimer interface [polypeptide binding]; other site 545693007576 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 545693007577 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693007578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007579 DNA-binding site [nucleotide binding]; DNA binding site 545693007580 FCD domain; Region: FCD; cl11656 545693007581 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 545693007582 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693007583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693007584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007585 Walker A/P-loop; other site 545693007586 ATP binding site [chemical binding]; other site 545693007587 Q-loop/lid; other site 545693007588 ABC transporter signature motif; other site 545693007589 Walker B; other site 545693007590 D-loop; other site 545693007591 H-loop/switch region; other site 545693007592 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693007593 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 545693007594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693007595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693007596 DNA binding residues [nucleotide binding] 545693007597 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 545693007598 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693007599 yiaA/B two helix domain; Region: YiaAB; cl01759 545693007600 Esterase/lipase [General function prediction only]; Region: COG1647 545693007601 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 545693007602 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693007603 active site 545693007604 dimer interface [polypeptide binding]; other site 545693007605 non-prolyl cis peptide bond; other site 545693007606 insertion regions; other site 545693007607 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693007608 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 545693007609 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 545693007610 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 545693007611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693007612 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 545693007613 putative active site [active] 545693007614 putative metal binding site [ion binding]; other site 545693007615 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693007616 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 545693007617 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 545693007618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693007619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693007621 dimer interface [polypeptide binding]; other site 545693007622 phosphorylation site [posttranslational modification] 545693007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693007624 Mg2+ binding site [ion binding]; other site 545693007625 G-X-G motif; other site 545693007626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693007627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693007628 active site 545693007629 phosphorylation site [posttranslational modification] 545693007630 intermolecular recognition site; other site 545693007631 dimerization interface [polypeptide binding]; other site 545693007632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693007633 DNA binding site [nucleotide binding] 545693007634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007635 hypothetical protein; Provisional; Region: PRK06184 545693007636 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 545693007637 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 545693007638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693007639 Helix-turn-helix domains; Region: HTH; cl00088 545693007640 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 545693007641 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 545693007642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693007643 E3 interaction surface; other site 545693007644 lipoyl attachment site [posttranslational modification]; other site 545693007645 e3 binding domain; Region: E3_binding; pfam02817 545693007646 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 545693007647 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 545693007648 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 545693007649 TPP-binding site [chemical binding]; other site 545693007650 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 545693007651 Helix-turn-helix domains; Region: HTH; cl00088 545693007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693007654 putative substrate translocation pore; other site 545693007655 OsmC-like protein; Region: OsmC; cl00767 545693007656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693007657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007658 NAD(P) binding site [chemical binding]; other site 545693007659 active site 545693007660 Predicted membrane protein [Function unknown]; Region: COG2311 545693007661 Protein of unknown function (DUF418); Region: DUF418; cl12135 545693007662 Protein of unknown function (DUF418); Region: DUF418; cl12135 545693007663 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693007664 OpgC protein; Region: OpgC_C; cl00792 545693007665 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693007666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 545693007667 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 545693007668 Walker A/P-loop; other site 545693007669 ATP binding site [chemical binding]; other site 545693007670 Q-loop/lid; other site 545693007671 ABC transporter signature motif; other site 545693007672 Walker B; other site 545693007673 D-loop; other site 545693007674 H-loop/switch region; other site 545693007675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 545693007676 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 545693007677 Walker A/P-loop; other site 545693007678 ATP binding site [chemical binding]; other site 545693007679 Q-loop/lid; other site 545693007680 ABC transporter signature motif; other site 545693007681 Walker B; other site 545693007682 D-loop; other site 545693007683 H-loop/switch region; other site 545693007684 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 545693007685 TM-ABC transporter signature motif; other site 545693007686 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 545693007687 TM-ABC transporter signature motif; other site 545693007688 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 545693007689 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 545693007690 dimerization interface [polypeptide binding]; other site 545693007691 ligand binding site [chemical binding]; other site 545693007692 Nitrogen regulatory protein P-II; Region: P-II; cl00412 545693007693 Nitrogen regulatory protein P-II; Region: P-II; smart00938 545693007694 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 545693007695 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693007696 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 545693007697 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 545693007698 active site 545693007699 putative catalytic site [active] 545693007700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693007701 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 545693007702 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693007703 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693007704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693007705 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 545693007706 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 545693007707 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 545693007708 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 545693007709 Predicted membrane protein [Function unknown]; Region: COG4640 545693007710 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 545693007711 YARHG domain; Region: YARHG; pfam13308 545693007712 PAS domain; Region: PAS_9; pfam13426 545693007713 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693007714 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693007715 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693007716 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 545693007717 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693007718 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 545693007719 putative dimer interface [polypeptide binding]; other site 545693007720 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693007721 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693007722 Walker A/P-loop; other site 545693007723 ATP binding site [chemical binding]; other site 545693007724 Q-loop/lid; other site 545693007725 ABC transporter signature motif; other site 545693007726 Walker B; other site 545693007727 D-loop; other site 545693007728 H-loop/switch region; other site 545693007729 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 545693007730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693007731 ABC-ATPase subunit interface; other site 545693007732 dimer interface [polypeptide binding]; other site 545693007733 putative PBP binding regions; other site 545693007734 cobyric acid synthase; Provisional; Region: PRK00784 545693007735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007737 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 545693007738 catalytic triad [active] 545693007739 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 545693007740 putative active site [active] 545693007741 amino acid transporter; Region: 2A0306; TIGR00909 545693007742 Spore germination protein; Region: Spore_permease; cl15802 545693007743 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 545693007744 dimer interface [polypeptide binding]; other site 545693007745 FMN binding site [chemical binding]; other site 545693007746 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693007747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007748 NAD(P) binding site [chemical binding]; other site 545693007749 active site 545693007750 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 545693007751 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 545693007752 tetramer interface [polypeptide binding]; other site 545693007753 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 545693007754 active site 545693007755 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 545693007756 active site 545693007757 dimer interface [polypeptide binding]; other site 545693007758 magnesium binding site [ion binding]; other site 545693007759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693007760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693007761 DNA binding site [nucleotide binding] 545693007762 domain linker motif; other site 545693007763 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 545693007764 putative dimerization interface [polypeptide binding]; other site 545693007765 putative ligand binding site [chemical binding]; other site 545693007766 KDPG and KHG aldolase; Region: Aldolase; pfam01081 545693007767 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 545693007768 active site 545693007769 intersubunit interface [polypeptide binding]; other site 545693007770 catalytic residue [active] 545693007771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693007772 D-galactonate transporter; Region: 2A0114; TIGR00893 545693007773 putative substrate translocation pore; other site 545693007774 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693007775 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693007776 substrate binding site [chemical binding]; other site 545693007777 ATP binding site [chemical binding]; other site 545693007778 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 545693007779 phytoene desaturase; Region: crtI_fam; TIGR02734 545693007780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007781 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 545693007782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693007783 active site 545693007784 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 545693007785 putative acyl-acceptor binding pocket; other site 545693007786 Protein of unknown function (DUF422); Region: DUF422; cl00991 545693007787 High-affinity nickel-transport protein; Region: NicO; cl00964 545693007788 UreD urease accessory protein; Region: UreD; cl00530 545693007789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007790 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 545693007791 UreF; Region: UreF; pfam01730 545693007792 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 545693007793 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 545693007794 dimer interface [polypeptide binding]; other site 545693007795 catalytic residues [active] 545693007796 urease subunit alpha; Reviewed; Region: ureC; PRK13207 545693007797 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 545693007798 subunit interactions [polypeptide binding]; other site 545693007799 active site 545693007800 flap region; other site 545693007801 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 545693007802 gamma-beta subunit interface [polypeptide binding]; other site 545693007803 alpha-beta subunit interface [polypeptide binding]; other site 545693007804 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 545693007805 alpha-gamma subunit interface [polypeptide binding]; other site 545693007806 beta-gamma subunit interface [polypeptide binding]; other site 545693007807 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 545693007808 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693007809 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693007810 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693007811 putative peptidoglycan binding site; other site 545693007812 NlpC/P60 family; Region: NLPC_P60; cl11438 545693007813 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693007814 putative peptidoglycan binding site; other site 545693007815 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693007816 putative peptidoglycan binding site; other site 545693007817 3D domain; Region: 3D; cl01439 545693007818 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 545693007819 dimer interface [polypeptide binding]; other site 545693007820 FMN binding site [chemical binding]; other site 545693007821 NADPH bind site [chemical binding]; other site 545693007822 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 545693007823 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 545693007824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693007825 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 545693007826 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 545693007827 NodB motif; other site 545693007828 putative active site [active] 545693007829 putative catalytic site [active] 545693007830 putative Zn binding site [ion binding]; other site 545693007831 Predicted esterase [General function prediction only]; Region: COG0400 545693007832 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693007833 Transglycosylase; Region: Transgly; cl07896 545693007834 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693007835 MatE; Region: MatE; cl10513 545693007836 MatE; Region: MatE; cl10513 545693007837 EamA-like transporter family; Region: EamA; cl01037 545693007838 EamA-like transporter family; Region: EamA; cl01037 545693007839 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693007840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693007841 DNA-binding site [nucleotide binding]; DNA binding site 545693007842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693007843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693007844 homodimer interface [polypeptide binding]; other site 545693007845 catalytic residue [active] 545693007846 FixH; Region: FixH; cl01254 545693007847 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 545693007848 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693007849 potential catalytic triad [active] 545693007850 conserved cys residue [active] 545693007851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693007852 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693007853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693007854 Walker A/P-loop; other site 545693007855 ATP binding site [chemical binding]; other site 545693007856 Q-loop/lid; other site 545693007857 ABC transporter signature motif; other site 545693007858 Walker B; other site 545693007859 D-loop; other site 545693007860 H-loop/switch region; other site 545693007861 Copper resistance protein D; Region: CopD; cl00563 545693007862 Bacterial Ig-like domain; Region: Big_5; cl01012 545693007863 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 545693007864 Protein of unknown function (DUF867); Region: DUF867; cl01713 545693007865 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 545693007866 Ferritin-like domain; Region: Ferritin; pfam00210 545693007867 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 545693007868 dimerization interface [polypeptide binding]; other site 545693007869 DPS ferroxidase diiron center [ion binding]; other site 545693007870 ion pore; other site 545693007871 Coat F domain; Region: Coat_F; cl15836 545693007872 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693007873 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693007874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693007875 Transporter associated domain; Region: CorC_HlyC; cl08393 545693007876 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 545693007877 SpoOM protein; Region: Spo0M; pfam07070 545693007878 FOG: CBS domain [General function prediction only]; Region: COG0517 545693007879 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693007880 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693007881 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 545693007882 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 545693007883 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 545693007884 [2Fe-2S] cluster binding site [ion binding]; other site 545693007885 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 545693007886 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 545693007887 hinge; other site 545693007888 active site 545693007889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693007890 Prephenate dehydrogenase; Region: PDH; pfam02153 545693007891 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 545693007892 Tetramer interface [polypeptide binding]; other site 545693007893 active site 545693007894 FMN-binding site [chemical binding]; other site 545693007895 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 545693007896 Chorismate mutase type II; Region: CM_2; cl00693 545693007897 NeuB family; Region: NeuB; cl00496 545693007898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007899 Coenzyme A binding pocket [chemical binding]; other site 545693007900 Chromate transporter; Region: Chromate_transp; pfam02417 545693007901 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 545693007902 Chromate transporter; Region: Chromate_transp; pfam02417 545693007903 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693007904 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 545693007905 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 545693007906 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 545693007907 homodimer interface [polypeptide binding]; other site 545693007908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693007909 catalytic residue [active] 545693007910 allantoate amidohydrolase; Reviewed; Region: PRK09290 545693007911 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 545693007912 active site 545693007913 metal binding site [ion binding]; metal-binding site 545693007914 dimer interface [polypeptide binding]; other site 545693007915 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 545693007916 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 545693007917 Helix-turn-helix domains; Region: HTH; cl00088 545693007918 Domain of unknown function DUF77; Region: DUF77; cl00307 545693007919 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693007920 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693007921 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693007922 NlpC/P60 family; Region: NLPC_P60; cl11438 545693007923 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693007924 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 545693007925 tetramer interface [polypeptide binding]; other site 545693007926 heme binding pocket [chemical binding]; other site 545693007927 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 545693007928 Predicted membrane protein [Function unknown]; Region: COG3766 545693007929 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693007930 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693007931 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 545693007932 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693007933 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693007934 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 545693007935 phosphate binding site [ion binding]; other site 545693007936 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693007937 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693007938 Catalytic site [active] 545693007939 FOG: CBS domain [General function prediction only]; Region: COG0517 545693007940 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 545693007941 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 545693007942 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 545693007943 Ligand Binding Site [chemical binding]; other site 545693007944 K+-transporting ATPase, c chain; Region: KdpC; cl00944 545693007945 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 545693007946 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693007947 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693007948 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 545693007949 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 545693007950 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 545693007951 active site 545693007952 homodimer interface [polypeptide binding]; other site 545693007953 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 545693007954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693007955 dimerization interface [polypeptide binding]; other site 545693007956 putative DNA binding site [nucleotide binding]; other site 545693007957 putative Zn2+ binding site [ion binding]; other site 545693007958 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693007959 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 545693007960 dimer interface [polypeptide binding]; other site 545693007961 FMN binding site [chemical binding]; other site 545693007962 NADPH bind site [chemical binding]; other site 545693007963 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693007964 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693007965 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 545693007966 Bacterial SH3 domain; Region: SH3_3; cl02551 545693007967 Bacterial SH3 domain; Region: SH3_3; cl02551 545693007968 Bacterial SH3 domain; Region: SH3_3; cl02551 545693007969 Bacterial SH3 domain; Region: SH3_3; cl02551 545693007970 Bacterial SH3 domain; Region: SH3_3; cl02551 545693007971 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693007972 active site 545693007973 metal binding site [ion binding]; metal-binding site 545693007974 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 545693007975 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693007976 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693007977 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693007978 DinB superfamily; Region: DinB_2; pfam12867 545693007979 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693007980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693007981 S-adenosylmethionine binding site [chemical binding]; other site 545693007982 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 545693007983 phosphopeptide binding site; other site 545693007984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693007985 DNA binding site [nucleotide binding] 545693007986 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 545693007987 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 545693007988 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 545693007989 putative dimer interface [polypeptide binding]; other site 545693007990 active site pocket [active] 545693007991 putative cataytic base [active] 545693007992 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693007993 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693007994 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693007995 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693007996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 545693007997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693007998 Coenzyme A binding pocket [chemical binding]; other site 545693007999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008000 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693008001 putative substrate translocation pore; other site 545693008002 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008003 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 545693008004 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 545693008005 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 545693008006 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 545693008007 dimer interface [polypeptide binding]; other site 545693008008 Citrate synthase; Region: Citrate_synt; pfam00285 545693008009 active site 545693008010 citrylCoA binding site [chemical binding]; other site 545693008011 oxalacetate/citrate binding site [chemical binding]; other site 545693008012 coenzyme A binding site [chemical binding]; other site 545693008013 catalytic triad [active] 545693008014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693008015 Helix-turn-helix domains; Region: HTH; cl00088 545693008016 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 545693008017 putative dimerization interface [polypeptide binding]; other site 545693008018 EamA-like transporter family; Region: EamA; cl01037 545693008019 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693008020 EamA-like transporter family; Region: EamA; cl01037 545693008021 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693008022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693008023 DNA-binding site [nucleotide binding]; DNA binding site 545693008024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693008025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693008026 homodimer interface [polypeptide binding]; other site 545693008027 catalytic residue [active] 545693008028 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 545693008029 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 545693008030 B12 binding site [chemical binding]; other site 545693008031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693008032 PAS domain; Region: PAS_9; pfam13426 545693008033 putative active site [active] 545693008034 heme pocket [chemical binding]; other site 545693008035 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008036 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008037 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008038 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693008039 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008040 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 545693008041 Clp protease; Region: CLP_protease; pfam00574 545693008042 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693008043 oligomer interface [polypeptide binding]; other site 545693008044 active site residues [active] 545693008045 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693008046 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 545693008047 DNA binding residues [nucleotide binding] 545693008048 dimer interface [polypeptide binding]; other site 545693008049 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 545693008050 nucleotide binding site/active site [active] 545693008051 HIT family signature motif; other site 545693008052 catalytic residue [active] 545693008053 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 545693008054 Aspartase; Region: Aspartase; cd01357 545693008055 active sites [active] 545693008056 tetramer interface [polypeptide binding]; other site 545693008057 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 545693008058 active site 545693008059 homodimer interface [polypeptide binding]; other site 545693008060 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 545693008061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693008062 non-specific DNA binding site [nucleotide binding]; other site 545693008063 salt bridge; other site 545693008064 sequence-specific DNA binding site [nucleotide binding]; other site 545693008065 chaperone protein DnaJ; Provisional; Region: PRK10767 545693008066 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 545693008067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008068 putative substrate translocation pore; other site 545693008069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693008070 dimerization interface [polypeptide binding]; other site 545693008071 putative DNA binding site [nucleotide binding]; other site 545693008072 putative Zn2+ binding site [ion binding]; other site 545693008073 Protein of unknown function, DUF606; Region: DUF606; cl01273 545693008074 Protein of unknown function, DUF606; Region: DUF606; cl01273 545693008075 amino acid transporter; Region: 2A0306; TIGR00909 545693008076 Spore germination protein; Region: Spore_permease; cl15802 545693008077 Helix-turn-helix domains; Region: HTH; cl00088 545693008078 Rrf2 family protein; Region: rrf2_super; TIGR00738 545693008079 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693008080 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 545693008081 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693008082 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 545693008083 putative NAD(P) binding site [chemical binding]; other site 545693008084 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 545693008085 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693008086 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693008087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693008088 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693008090 classical (c) SDRs; Region: SDR_c; cd05233 545693008091 NAD(P) binding site [chemical binding]; other site 545693008092 active site 545693008093 sulfite reductase subunit beta; Provisional; Region: PRK13504 545693008094 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693008095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 545693008096 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 545693008097 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693008098 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 545693008099 FAD binding pocket [chemical binding]; other site 545693008100 FAD binding motif [chemical binding]; other site 545693008101 catalytic residues [active] 545693008102 NAD binding pocket [chemical binding]; other site 545693008103 phosphate binding motif [ion binding]; other site 545693008104 beta-alpha-beta structure motif; other site 545693008105 YolD-like protein; Region: YolD; pfam08863 545693008106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693008108 putative substrate translocation pore; other site 545693008109 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693008110 Helix-turn-helix domains; Region: HTH; cl00088 545693008111 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693008112 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693008113 DNA binding residues [nucleotide binding] 545693008114 dimer interface [polypeptide binding]; other site 545693008115 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 545693008116 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008117 Rhamnan synthesis protein F; Region: RgpF; cl01529 545693008118 Spore germination protein; Region: Spore_permease; cl15802 545693008119 CAAX protease self-immunity; Region: Abi; cl00558 545693008120 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693008121 glycosyltransferase, MGT family; Region: MGT; TIGR01426 545693008122 active site 545693008123 TDP-binding site; other site 545693008124 acceptor substrate-binding pocket; other site 545693008125 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 545693008126 FMN binding site [chemical binding]; other site 545693008127 active site 545693008128 substrate binding site [chemical binding]; other site 545693008129 catalytic residue [active] 545693008130 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 545693008131 active site 545693008132 catalytic triad [active] 545693008133 oxyanion hole [active] 545693008134 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693008135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008136 Helix-turn-helix domains; Region: HTH; cl00088 545693008137 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 545693008138 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 545693008139 imidazolonepropionase; Validated; Region: PRK09356 545693008140 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 545693008141 active site 545693008142 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693008143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008145 Coenzyme A binding pocket [chemical binding]; other site 545693008146 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008147 Bacitracin resistance protein BacA; Region: BacA; cl00858 545693008148 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 545693008149 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 545693008150 Subunit I/III interface [polypeptide binding]; other site 545693008151 Subunit III/IV interface [polypeptide binding]; other site 545693008152 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 545693008153 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 545693008154 D-pathway; other site 545693008155 Putative ubiquinol binding site [chemical binding]; other site 545693008156 Low-spin heme (heme b) binding site [chemical binding]; other site 545693008157 Putative water exit pathway; other site 545693008158 Binuclear center (heme o3/CuB) [ion binding]; other site 545693008159 K-pathway; other site 545693008160 Putative proton exit pathway; other site 545693008161 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 545693008162 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 545693008163 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 545693008164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 545693008165 active site residue [active] 545693008166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693008167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693008168 dimerization interface [polypeptide binding]; other site 545693008169 putative DNA binding site [nucleotide binding]; other site 545693008170 putative Zn2+ binding site [ion binding]; other site 545693008171 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693008172 metal-binding site [ion binding] 545693008173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 545693008174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 545693008175 metal-binding site [ion binding] 545693008176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693008177 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693008178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693008179 S-adenosylmethionine binding site [chemical binding]; other site 545693008180 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 545693008181 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693008182 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693008183 active site 545693008184 metal binding site [ion binding]; metal-binding site 545693008185 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693008186 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693008187 putative peptidoglycan binding site; other site 545693008188 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693008189 putative peptidoglycan binding site; other site 545693008190 LysE type translocator; Region: LysE; cl00565 545693008191 amino acid transporter; Region: 2A0306; TIGR00909 545693008192 Spore germination protein; Region: Spore_permease; cl15802 545693008193 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693008194 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 545693008195 active site 545693008196 catalytic site [active] 545693008197 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693008198 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008199 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008200 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693008201 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008203 Prostaglandin dehydrogenases; Region: PGDH; cd05288 545693008204 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 545693008205 NAD(P) binding site [chemical binding]; other site 545693008206 substrate binding site [chemical binding]; other site 545693008207 dimer interface [polypeptide binding]; other site 545693008208 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693008209 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008210 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008211 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008212 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693008213 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 545693008214 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 545693008215 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 545693008216 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693008217 Peptidase family M48; Region: Peptidase_M48; cl12018 545693008218 Helix-turn-helix domains; Region: HTH; cl00088 545693008219 YvrJ protein family; Region: YvrJ; pfam12841 545693008220 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 545693008221 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 545693008222 Divergent AAA domain; Region: AAA_4; pfam04326 545693008223 hypothetical protein; Validated; Region: PRK06769 545693008224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008225 active site 545693008226 motif I; other site 545693008227 motif II; other site 545693008228 Protein of unknown function (DUF867); Region: DUF867; cl01713 545693008229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008230 Helix-turn-helix domains; Region: HTH; cl00088 545693008231 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693008232 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 545693008233 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 545693008234 G1 box; other site 545693008235 putative GEF interaction site [polypeptide binding]; other site 545693008236 GTP/Mg2+ binding site [chemical binding]; other site 545693008237 Switch I region; other site 545693008238 G2 box; other site 545693008239 G3 box; other site 545693008240 Switch II region; other site 545693008241 G4 box; other site 545693008242 G5 box; other site 545693008243 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 545693008244 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693008245 DNA-binding site [nucleotide binding]; DNA binding site 545693008246 RNA-binding motif; other site 545693008247 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693008248 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693008249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693008250 NAD binding site [chemical binding]; other site 545693008251 substrate binding site [chemical binding]; other site 545693008252 putative active site [active] 545693008253 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 545693008254 Protease prsW family; Region: PrsW-protease; cl15823 545693008255 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008256 dimanganese center [ion binding]; other site 545693008257 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008258 dimanganese center [ion binding]; other site 545693008259 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 545693008260 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 545693008261 putative ligand binding residues [chemical binding]; other site 545693008262 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 545693008263 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693008264 Walker A/P-loop; other site 545693008265 ATP binding site [chemical binding]; other site 545693008266 Q-loop/lid; other site 545693008267 ABC transporter signature motif; other site 545693008268 Walker B; other site 545693008269 D-loop; other site 545693008270 H-loop/switch region; other site 545693008271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693008272 ABC-ATPase subunit interface; other site 545693008273 dimer interface [polypeptide binding]; other site 545693008274 putative PBP binding regions; other site 545693008275 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 545693008276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693008277 ABC-ATPase subunit interface; other site 545693008278 dimer interface [polypeptide binding]; other site 545693008279 putative PBP binding regions; other site 545693008280 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693008281 putative peptidoglycan binding site; other site 545693008282 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693008283 putative peptidoglycan binding site; other site 545693008284 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693008285 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693008286 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 545693008287 putative NAD(P) binding site [chemical binding]; other site 545693008288 catalytic Zn binding site [ion binding]; other site 545693008289 structural Zn binding site [ion binding]; other site 545693008290 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 545693008291 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 545693008292 putative NAD(P) binding site [chemical binding]; other site 545693008293 catalytic Zn binding site [ion binding]; other site 545693008294 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 545693008295 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 545693008296 active site 545693008297 P-loop; other site 545693008298 phosphorylation site [posttranslational modification] 545693008299 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 545693008300 active site 545693008301 P-loop; other site 545693008302 phosphorylation site [posttranslational modification] 545693008303 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693008304 active site 545693008305 phosphorylation site [posttranslational modification] 545693008306 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 545693008307 PRD domain; Region: PRD; cl15445 545693008308 PRD domain; Region: PRD; cl15445 545693008309 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 545693008310 active site 545693008311 P-loop; other site 545693008312 phosphorylation site [posttranslational modification] 545693008313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 545693008314 active site 545693008315 phosphorylation site [posttranslational modification] 545693008316 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693008317 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693008318 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693008319 Catalytic site [active] 545693008320 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693008321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 545693008322 Protein of unknown function (DUF975); Region: DUF975; cl10504 545693008323 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693008324 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693008325 Helix-turn-helix domains; Region: HTH; cl00088 545693008326 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693008327 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 545693008328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693008329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693008330 catalytic residue [active] 545693008331 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 545693008332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008333 motif II; other site 545693008334 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 545693008335 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 545693008336 Walker A/P-loop; other site 545693008337 ATP binding site [chemical binding]; other site 545693008338 Q-loop/lid; other site 545693008339 ABC transporter signature motif; other site 545693008340 Walker B; other site 545693008341 D-loop; other site 545693008342 H-loop/switch region; other site 545693008343 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 545693008344 AzlC protein; Region: AzlC; cl00570 545693008345 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693008346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693008347 non-specific DNA binding site [nucleotide binding]; other site 545693008348 salt bridge; other site 545693008349 sequence-specific DNA binding site [nucleotide binding]; other site 545693008350 Cupin domain; Region: Cupin_2; cl09118 545693008351 Integral membrane protein TerC family; Region: TerC; cl10468 545693008352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693008353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693008354 DNA binding site [nucleotide binding] 545693008355 domain linker motif; other site 545693008356 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 545693008357 dimerization interface [polypeptide binding]; other site 545693008358 ligand binding site [chemical binding]; other site 545693008359 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693008360 Helix-turn-helix domains; Region: HTH; cl00088 545693008361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 545693008362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693008363 Radical SAM superfamily; Region: Radical_SAM; pfam04055 545693008364 FeS/SAM binding site; other site 545693008365 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008366 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 545693008367 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008368 Gas vesicle protein G; Region: GvpG; pfam05120 545693008369 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008370 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008371 Gas vesicle protein K; Region: GvpK; pfam05121 545693008372 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008373 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693008374 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 545693008375 folate binding site [chemical binding]; other site 545693008376 NADP+ binding site [chemical binding]; other site 545693008377 Predicted transcriptional regulator [Transcription]; Region: COG2378 545693008378 Helix-turn-helix domains; Region: HTH; cl00088 545693008379 WYL domain; Region: WYL; cl14852 545693008380 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693008381 Cytochrome P450; Region: p450; pfam00067 545693008382 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 545693008383 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693008384 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 545693008385 FAD binding pocket [chemical binding]; other site 545693008386 FAD binding motif [chemical binding]; other site 545693008387 catalytic residues [active] 545693008388 NAD binding pocket [chemical binding]; other site 545693008389 phosphate binding motif [ion binding]; other site 545693008390 beta-alpha-beta structure motif; other site 545693008391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008392 Helix-turn-helix domains; Region: HTH; cl00088 545693008393 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 545693008394 Uncharacterized conserved protein [Function unknown]; Region: COG1633 545693008395 dimanganese center [ion binding]; other site 545693008396 CotJB protein; Region: CotJB; pfam12652 545693008397 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 545693008398 LysE type translocator; Region: LysE; cl00565 545693008399 Cupin domain; Region: Cupin_2; cl09118 545693008400 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693008401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693008402 Histidine kinase; Region: HisKA_3; pfam07730 545693008403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008404 ATP binding site [chemical binding]; other site 545693008405 Mg2+ binding site [ion binding]; other site 545693008406 G-X-G motif; other site 545693008407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693008408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693008409 active site 545693008410 phosphorylation site [posttranslational modification] 545693008411 intermolecular recognition site; other site 545693008412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693008413 DNA binding residues [nucleotide binding] 545693008414 dimerization interface [polypeptide binding]; other site 545693008415 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 545693008416 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693008417 putative active site [active] 545693008418 catalytic site [active] 545693008419 putative metal binding site [ion binding]; other site 545693008420 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 545693008421 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 545693008422 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 545693008423 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693008424 FixH; Region: FixH; cl01254 545693008425 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693008426 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 545693008427 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693008428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693008429 Helix-turn-helix domains; Region: HTH; cl00088 545693008430 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 545693008431 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 545693008432 homodimer interface [polypeptide binding]; other site 545693008433 active site 545693008434 TDP-binding site; other site 545693008435 acceptor substrate-binding pocket; other site 545693008436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008437 Coenzyme A binding pocket [chemical binding]; other site 545693008438 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008439 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693008440 active site 545693008441 intersubunit interactions; other site 545693008442 catalytic residue [active] 545693008443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008444 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 545693008445 transketolase; Reviewed; Region: PRK05899 545693008446 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693008447 TPP-binding site [chemical binding]; other site 545693008448 dimer interface [polypeptide binding]; other site 545693008449 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693008450 PYR/PP interface [polypeptide binding]; other site 545693008451 dimer interface [polypeptide binding]; other site 545693008452 TPP binding site [chemical binding]; other site 545693008453 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693008454 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693008455 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693008456 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693008457 GAF domain; Region: GAF_2; pfam13185 545693008458 GAF domain; Region: GAF; cl15785 545693008459 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008460 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008461 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693008462 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 545693008463 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 545693008464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693008465 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693008466 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693008467 Walker A/P-loop; other site 545693008468 ATP binding site [chemical binding]; other site 545693008469 Q-loop/lid; other site 545693008470 ABC transporter signature motif; other site 545693008471 Walker B; other site 545693008472 D-loop; other site 545693008473 H-loop/switch region; other site 545693008474 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 545693008475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 545693008476 FtsX-like permease family; Region: FtsX; cl15850 545693008477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693008478 dimerization interface [polypeptide binding]; other site 545693008479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693008480 dimer interface [polypeptide binding]; other site 545693008481 phosphorylation site [posttranslational modification] 545693008482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008483 ATP binding site [chemical binding]; other site 545693008484 Mg2+ binding site [ion binding]; other site 545693008485 G-X-G motif; other site 545693008486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693008487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693008488 active site 545693008489 phosphorylation site [posttranslational modification] 545693008490 intermolecular recognition site; other site 545693008491 dimerization interface [polypeptide binding]; other site 545693008492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693008493 DNA binding site [nucleotide binding] 545693008494 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 545693008495 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 545693008496 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 545693008497 GAF domain; Region: GAF; cl15785 545693008498 GAF domain; Region: GAF_2; pfam13185 545693008499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693008500 phosphorylation site [posttranslational modification] 545693008501 dimer interface [polypeptide binding]; other site 545693008502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008503 ATP binding site [chemical binding]; other site 545693008504 Mg2+ binding site [ion binding]; other site 545693008505 G-X-G motif; other site 545693008506 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008507 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008509 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 545693008510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008511 Coenzyme A binding pocket [chemical binding]; other site 545693008512 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693008513 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693008514 DNA binding residues [nucleotide binding] 545693008515 putative dimer interface [polypeptide binding]; other site 545693008516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693008517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693008518 active site 545693008519 catalytic tetrad [active] 545693008520 EamA-like transporter family; Region: EamA; cl01037 545693008521 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693008522 EamA-like transporter family; Region: EamA; cl01037 545693008523 Cupin domain; Region: Cupin_2; cl09118 545693008524 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 545693008525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693008526 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008527 Gas vesicle protein K; Region: GvpK; pfam05121 545693008528 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008529 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008530 Gas vesicle protein G; Region: GvpG; pfam05120 545693008531 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 545693008532 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 545693008533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693008534 Walker A motif; other site 545693008535 ATP binding site [chemical binding]; other site 545693008536 Walker B motif; other site 545693008537 arginine finger; other site 545693008538 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 545693008539 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008540 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 545693008541 Gas vesicle protein; Region: Gas_vesicle; cl02954 545693008542 Heat induced stress protein YflT; Region: YflT; pfam11181 545693008543 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693008544 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693008545 hypothetical protein; Provisional; Region: PRK10220 545693008546 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 545693008547 PhnA protein; Region: PhnA; pfam03831 545693008548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693008549 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693008550 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 545693008551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693008552 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693008553 Ferredoxin [Energy production and conversion]; Region: COG1146 545693008554 4Fe-4S binding domain; Region: Fer4; cl02805 545693008555 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 545693008556 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693008557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 545693008558 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 545693008559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693008560 substrate binding pocket [chemical binding]; other site 545693008561 membrane-bound complex binding site; other site 545693008562 hinge residues; other site 545693008563 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693008564 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 545693008565 Walker A/P-loop; other site 545693008566 ATP binding site [chemical binding]; other site 545693008567 Q-loop/lid; other site 545693008568 ABC transporter signature motif; other site 545693008569 Walker B; other site 545693008570 D-loop; other site 545693008571 H-loop/switch region; other site 545693008572 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 545693008573 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 545693008574 benzoate transport; Region: 2A0115; TIGR00895 545693008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008576 putative substrate translocation pore; other site 545693008577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008578 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008580 Coenzyme A binding pocket [chemical binding]; other site 545693008581 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 545693008582 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 545693008583 metal binding site [ion binding]; metal-binding site 545693008584 dimer interface [polypeptide binding]; other site 545693008585 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 545693008586 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 545693008587 active site 545693008588 non-prolyl cis peptide bond; other site 545693008589 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 545693008590 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693008591 active site 545693008592 dimer interface [polypeptide binding]; other site 545693008593 non-prolyl cis peptide bond; other site 545693008594 insertion regions; other site 545693008595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693008596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693008597 active site 545693008598 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 545693008599 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 545693008600 putative NAD(P) binding site [chemical binding]; other site 545693008601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693008602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693008603 active site 545693008604 phosphorylation site [posttranslational modification] 545693008605 intermolecular recognition site; other site 545693008606 dimerization interface [polypeptide binding]; other site 545693008607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693008608 DNA binding site [nucleotide binding] 545693008609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 545693008610 dimer interface [polypeptide binding]; other site 545693008611 phosphorylation site [posttranslational modification] 545693008612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693008613 ATP binding site [chemical binding]; other site 545693008614 Mg2+ binding site [ion binding]; other site 545693008615 G-X-G motif; other site 545693008616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693008617 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693008618 Walker A/P-loop; other site 545693008619 ATP binding site [chemical binding]; other site 545693008620 Q-loop/lid; other site 545693008621 ABC transporter signature motif; other site 545693008622 Walker B; other site 545693008623 D-loop; other site 545693008624 H-loop/switch region; other site 545693008625 FtsX-like permease family; Region: FtsX; cl15850 545693008626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693008627 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008628 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 545693008629 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 545693008630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693008631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693008632 homodimer interface [polypeptide binding]; other site 545693008633 catalytic residue [active] 545693008634 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693008635 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693008636 CPxP motif; other site 545693008637 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 545693008638 active site residue [active] 545693008639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693008640 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693008641 CPxP motif; other site 545693008642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693008643 active site residue [active] 545693008644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693008645 active site residue [active] 545693008646 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693008647 active site residue [active] 545693008648 DsrE/DsrF-like family; Region: DrsE; cl00672 545693008649 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 545693008650 CPxP motif; other site 545693008651 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 545693008652 putative homodimer interface [polypeptide binding]; other site 545693008653 putative homotetramer interface [polypeptide binding]; other site 545693008654 putative metal binding site [ion binding]; other site 545693008655 putative homodimer-homodimer interface [polypeptide binding]; other site 545693008656 putative allosteric switch controlling residues; other site 545693008657 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 545693008658 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 545693008659 NAD binding site [chemical binding]; other site 545693008660 homotetramer interface [polypeptide binding]; other site 545693008661 homodimer interface [polypeptide binding]; other site 545693008662 substrate binding site [chemical binding]; other site 545693008663 active site 545693008664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693008665 Helix-turn-helix domains; Region: HTH; cl00088 545693008666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693008667 dimerization interface [polypeptide binding]; other site 545693008668 EamA-like transporter family; Region: EamA; cl01037 545693008669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693008670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008671 Coenzyme A binding pocket [chemical binding]; other site 545693008672 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693008673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693008674 DNA-binding site [nucleotide binding]; DNA binding site 545693008675 UTRA domain; Region: UTRA; cl01230 545693008676 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 545693008677 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693008678 active site turn [active] 545693008679 phosphorylation site [posttranslational modification] 545693008680 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693008681 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 545693008682 HPr interaction site; other site 545693008683 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693008684 active site 545693008685 phosphorylation site [posttranslational modification] 545693008686 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 545693008687 Sodium:solute symporter family; Region: SSF; cl00456 545693008688 Excalibur calcium-binding domain; Region: Excalibur; cl05460 545693008689 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693008690 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 545693008691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693008692 non-specific DNA binding site [nucleotide binding]; other site 545693008693 salt bridge; other site 545693008694 sequence-specific DNA binding site [nucleotide binding]; other site 545693008695 Cupin domain; Region: Cupin_2; cl09118 545693008696 LysE type translocator; Region: LysE; cl00565 545693008697 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 545693008698 DNA binding site [nucleotide binding] 545693008699 active site 545693008700 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693008701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693008702 Helix-turn-helix domains; Region: HTH; cl00088 545693008703 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693008704 putative dimerization interface [polypeptide binding]; other site 545693008705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008706 putative substrate translocation pore; other site 545693008707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693008708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693008709 active site 545693008710 metal binding site [ion binding]; metal-binding site 545693008711 histidinol-phosphatase; Provisional; Region: PRK07328 545693008712 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 545693008713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693008714 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 545693008715 glucose-1-dehydrogenase; Provisional; Region: PRK08936 545693008716 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 545693008717 NAD binding site [chemical binding]; other site 545693008718 homodimer interface [polypeptide binding]; other site 545693008719 active site 545693008720 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693008721 dimer interface [polypeptide binding]; other site 545693008722 FMN binding site [chemical binding]; other site 545693008723 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 545693008724 NAD(P) binding site [chemical binding]; other site 545693008725 catalytic residues [active] 545693008726 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 545693008727 Repair protein; Region: Repair_PSII; cl01535 545693008728 LemA family; Region: LemA; cl00742 545693008729 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 545693008730 Helix-turn-helix domains; Region: HTH; cl00088 545693008731 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693008732 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693008733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693008734 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008735 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 545693008736 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693008737 Zn binding site [ion binding]; other site 545693008738 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693008739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693008740 Zn binding site [ion binding]; other site 545693008741 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693008742 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693008743 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693008744 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693008745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 545693008746 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 545693008747 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 545693008748 Protein of unknown function DUF45; Region: DUF45; cl00636 545693008749 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 545693008750 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693008751 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008752 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693008753 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693008754 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693008755 DNA-binding site [nucleotide binding]; DNA binding site 545693008756 RNA-binding motif; other site 545693008757 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693008758 DNA-binding site [nucleotide binding]; DNA binding site 545693008759 RNA-binding motif; other site 545693008760 proline/glycine betaine transporter; Provisional; Region: PRK10642 545693008761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008762 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 545693008763 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 545693008764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 545693008765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693008766 dimer interface [polypeptide binding]; other site 545693008767 conserved gate region; other site 545693008768 putative PBP binding loops; other site 545693008769 ABC-ATPase subunit interface; other site 545693008770 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 545693008771 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 545693008772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693008773 dimer interface [polypeptide binding]; other site 545693008774 conserved gate region; other site 545693008775 putative PBP binding loops; other site 545693008776 ABC-ATPase subunit interface; other site 545693008777 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 545693008778 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693008779 Walker A/P-loop; other site 545693008780 ATP binding site [chemical binding]; other site 545693008781 Q-loop/lid; other site 545693008782 ABC transporter signature motif; other site 545693008783 Walker B; other site 545693008784 D-loop; other site 545693008785 H-loop/switch region; other site 545693008786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693008787 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 545693008788 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 545693008789 Walker A/P-loop; other site 545693008790 ATP binding site [chemical binding]; other site 545693008791 Q-loop/lid; other site 545693008792 ABC transporter signature motif; other site 545693008793 Walker B; other site 545693008794 D-loop; other site 545693008795 H-loop/switch region; other site 545693008796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 545693008797 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 545693008798 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 545693008799 threonine synthase; Validated; Region: PRK08197 545693008800 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693008801 homodimer interface [polypeptide binding]; other site 545693008802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693008803 catalytic residue [active] 545693008804 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693008805 Helix-turn-helix domains; Region: HTH; cl00088 545693008806 Helix-turn-helix domains; Region: HTH; cl00088 545693008807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008809 putative substrate translocation pore; other site 545693008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008811 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693008812 classical (c) SDRs; Region: SDR_c; cd05233 545693008813 NAD(P) binding site [chemical binding]; other site 545693008814 active site 545693008815 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 545693008816 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 545693008817 active site 545693008818 substrate binding pocket [chemical binding]; other site 545693008819 homodimer interaction site [polypeptide binding]; other site 545693008820 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 545693008821 intersubunit interface [polypeptide binding]; other site 545693008822 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693008823 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693008824 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 545693008825 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 545693008826 putative active site [active] 545693008827 putative catalytic site [active] 545693008828 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 545693008829 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 545693008830 Protein of unknown function DUF111; Region: DUF111; cl03398 545693008831 Protein of unknown function DUF111; Region: DUF111; cl03398 545693008832 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 545693008833 AIR carboxylase; Region: AIRC; cl00310 545693008834 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 545693008835 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 545693008836 Ligand Binding Site [chemical binding]; other site 545693008837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693008839 NAD(P) binding site [chemical binding]; other site 545693008840 active site 545693008841 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 545693008842 Glucuronate isomerase; Region: UxaC; cl00829 545693008843 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 545693008844 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 545693008845 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693008846 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693008847 Walker A/P-loop; other site 545693008848 ATP binding site [chemical binding]; other site 545693008849 Q-loop/lid; other site 545693008850 ABC transporter signature motif; other site 545693008851 Walker B; other site 545693008852 D-loop; other site 545693008853 H-loop/switch region; other site 545693008854 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 545693008855 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 545693008856 Helix-turn-helix domains; Region: HTH; cl00088 545693008857 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 545693008858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693008859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693008860 DNA binding residues [nucleotide binding] 545693008861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008862 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693008863 active site 545693008864 motif I; other site 545693008865 motif II; other site 545693008866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693008867 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 545693008868 Erythromycin esterase; Region: Erythro_esteras; pfam05139 545693008869 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693008870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693008871 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 545693008872 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 545693008873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693008874 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693008875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693008876 Helix-turn-helix domains; Region: HTH; cl00088 545693008877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693008878 dimerization interface [polypeptide binding]; other site 545693008879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693008880 classical (c) SDRs; Region: SDR_c; cd05233 545693008881 NAD(P) binding site [chemical binding]; other site 545693008882 active site 545693008883 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 545693008884 active site 545693008885 NTP binding site [chemical binding]; other site 545693008886 metal binding triad [ion binding]; metal-binding site 545693008887 antibiotic binding site [chemical binding]; other site 545693008888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693008889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693008890 DNA binding site [nucleotide binding] 545693008891 domain linker motif; other site 545693008892 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 545693008893 dimerization interface [polypeptide binding]; other site 545693008894 ligand binding site [chemical binding]; other site 545693008895 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693008896 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 545693008897 DNA interaction; other site 545693008898 Metal-binding active site; metal-binding site 545693008899 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693008900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008901 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693008902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693008904 putative substrate translocation pore; other site 545693008905 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693008906 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693008907 tetrameric interface [polypeptide binding]; other site 545693008908 NAD binding site [chemical binding]; other site 545693008909 catalytic residues [active] 545693008910 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693008911 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693008912 substrate binding site [chemical binding]; other site 545693008913 ATP binding site [chemical binding]; other site 545693008914 KduI/IolB family; Region: KduI; cl01508 545693008915 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 545693008916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693008917 PYR/PP interface [polypeptide binding]; other site 545693008918 dimer interface [polypeptide binding]; other site 545693008919 TPP binding site [chemical binding]; other site 545693008920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693008921 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 545693008922 TPP-binding site; other site 545693008923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693008924 Helix-turn-helix domains; Region: HTH; cl00088 545693008925 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693008926 hypothetical protein; Provisional; Region: PRK08185 545693008927 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 545693008928 intersubunit interface [polypeptide binding]; other site 545693008929 active site 545693008930 zinc binding site [ion binding]; other site 545693008931 Na+ binding site [ion binding]; other site 545693008932 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693008933 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 545693008934 Metal-binding active site; metal-binding site 545693008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008936 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693008937 putative substrate translocation pore; other site 545693008938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008939 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693008940 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 545693008941 Metal-binding active site; metal-binding site 545693008942 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693008943 dimerization domain swap beta strand [polypeptide binding]; other site 545693008944 regulatory protein interface [polypeptide binding]; other site 545693008945 active site 545693008946 regulatory phosphorylation site [posttranslational modification]; other site 545693008947 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 545693008948 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 545693008949 putative NAD(P) binding site [chemical binding]; other site 545693008950 putative substrate binding site [chemical binding]; other site 545693008951 catalytic Zn binding site [ion binding]; other site 545693008952 structural Zn binding site [ion binding]; other site 545693008953 dimer interface [polypeptide binding]; other site 545693008954 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693008955 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693008956 DNA binding residues [nucleotide binding] 545693008957 putative dimer interface [polypeptide binding]; other site 545693008958 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693008959 Cupin domain; Region: Cupin_2; cl09118 545693008960 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008961 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693008962 DNA-binding site [nucleotide binding]; DNA binding site 545693008963 RNA-binding motif; other site 545693008964 Bacterial SH3 domain; Region: SH3_3; cl02551 545693008965 Bacterial SH3 domain; Region: SH3_3; cl02551 545693008966 Bacterial SH3 domain; Region: SH3_3; cl02551 545693008967 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 545693008968 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 545693008969 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 545693008970 dimerization interface [polypeptide binding]; other site 545693008971 putative active cleft [active] 545693008972 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 545693008973 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 545693008974 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693008975 short chain dehydrogenase; Provisional; Region: PRK06701 545693008976 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 545693008977 NAD binding site [chemical binding]; other site 545693008978 metal binding site [ion binding]; metal-binding site 545693008979 active site 545693008980 Heat induced stress protein YflT; Region: YflT; pfam11181 545693008981 short chain dehydrogenase; Provisional; Region: PRK06701 545693008982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693008983 NAD(P) binding site [chemical binding]; other site 545693008984 active site 545693008985 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 545693008986 active site 545693008987 Zn binding site [ion binding]; other site 545693008988 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 545693008989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693008990 Coenzyme A binding pocket [chemical binding]; other site 545693008991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693008992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693008993 putative substrate translocation pore; other site 545693008994 hypothetical protein; Provisional; Region: PRK08296 545693008995 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 545693008996 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 545693008997 Sodium:solute symporter family; Region: SSF; cl00456 545693008998 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693008999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009000 DNA-binding site [nucleotide binding]; DNA binding site 545693009001 FCD domain; Region: FCD; cl11656 545693009002 CAAX protease self-immunity; Region: Abi; cl00558 545693009003 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 545693009004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009005 Coenzyme A binding pocket [chemical binding]; other site 545693009006 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 545693009007 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693009008 Helix-turn-helix domains; Region: HTH; cl00088 545693009009 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693009010 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693009011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009012 active site 545693009013 motif I; other site 545693009014 motif II; other site 545693009015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009016 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693009017 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 545693009018 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 545693009019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009020 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 545693009021 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 545693009022 LysE type translocator; Region: LysE; cl00565 545693009023 membrane protein insertase; Provisional; Region: PRK01318 545693009024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009025 non-specific DNA binding site [nucleotide binding]; other site 545693009026 salt bridge; other site 545693009027 sequence-specific DNA binding site [nucleotide binding]; other site 545693009028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009030 Coenzyme A binding pocket [chemical binding]; other site 545693009031 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 545693009032 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 545693009033 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 545693009034 THF binding site; other site 545693009035 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 545693009036 substrate binding site [chemical binding]; other site 545693009037 THF binding site; other site 545693009038 zinc-binding site [ion binding]; other site 545693009039 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693009040 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693009041 active site 545693009042 metal binding site [ion binding]; metal-binding site 545693009043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009044 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693009045 putative substrate translocation pore; other site 545693009046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009047 L-arabinose isomerase; Provisional; Region: PRK02929 545693009048 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 545693009049 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693009050 trimer interface [polypeptide binding]; other site 545693009051 substrate binding site [chemical binding]; other site 545693009052 Mn binding site [ion binding]; other site 545693009053 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 545693009054 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 545693009055 intersubunit interface [polypeptide binding]; other site 545693009056 active site 545693009057 Zn2+ binding site [ion binding]; other site 545693009058 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 545693009059 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 545693009060 putative N- and C-terminal domain interface [polypeptide binding]; other site 545693009061 putative active site [active] 545693009062 putative MgATP binding site [chemical binding]; other site 545693009063 catalytic site [active] 545693009064 metal binding site [ion binding]; metal-binding site 545693009065 putative carbohydrate binding site [chemical binding]; other site 545693009066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009067 DNA-binding site [nucleotide binding]; DNA binding site 545693009068 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009069 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 545693009070 putative dimerization interface [polypeptide binding]; other site 545693009071 putative ligand binding site [chemical binding]; other site 545693009072 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 545693009073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693009074 FixH; Region: FixH; cl01254 545693009075 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 545693009076 Nucleoside recognition; Region: Gate; cl00486 545693009077 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 545693009078 Nucleoside recognition; Region: Gate; cl00486 545693009079 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 545693009080 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 545693009081 G1 box; other site 545693009082 GTP/Mg2+ binding site [chemical binding]; other site 545693009083 Switch I region; other site 545693009084 G2 box; other site 545693009085 G3 box; other site 545693009086 Switch II region; other site 545693009087 G4 box; other site 545693009088 G5 box; other site 545693009089 FeoA domain; Region: FeoA; cl00838 545693009090 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693009091 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693009092 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 545693009093 dimer interface [polypeptide binding]; other site 545693009094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693009095 metal binding site [ion binding]; metal-binding site 545693009096 FixH; Region: FixH; cl01254 545693009097 Helix-turn-helix domains; Region: HTH; cl00088 545693009098 transcriptional regulator SlyA; Provisional; Region: PRK03573 545693009099 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 545693009100 RNA polymerase factor sigma-70; Validated; Region: PRK06811 545693009101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693009103 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 545693009104 putative dimer interface [polypeptide binding]; other site 545693009105 catalytic triad [active] 545693009106 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 545693009107 Protein of unknown function (DUF975); Region: DUF975; cl10504 545693009108 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 545693009109 EamA-like transporter family; Region: EamA; cl01037 545693009110 Bacterial SH3 domain; Region: SH3_3; cl02551 545693009111 NlpC/P60 family; Region: NLPC_P60; cl11438 545693009112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 545693009113 MOSC domain; Region: MOSC; pfam03473 545693009114 3-alpha domain; Region: 3-alpha; pfam03475 545693009115 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 545693009116 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 545693009117 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 545693009118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693009119 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 545693009120 active site 545693009121 DNA binding site [nucleotide binding] 545693009122 Int/Topo IB signature motif; other site 545693009123 Small acid-soluble spore protein H family; Region: SspH; cl06949 545693009124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009125 Helix-turn-helix domains; Region: HTH; cl00088 545693009126 kynureninase; Region: kynureninase; TIGR01814 545693009127 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693009128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693009129 catalytic residue [active] 545693009130 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693009131 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 545693009132 Putative cyclase; Region: Cyclase; cl00814 545693009133 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 545693009134 active site 1 [active] 545693009135 dimer interface [polypeptide binding]; other site 545693009136 hexamer interface [polypeptide binding]; other site 545693009137 active site 2 [active] 545693009138 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693009139 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 545693009140 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 545693009141 active site 545693009142 catalytic residues [active] 545693009143 metal binding site [ion binding]; metal-binding site 545693009144 DmpG-like communication domain; Region: DmpG_comm; pfam07836 545693009145 acetaldehyde dehydrogenase; Validated; Region: PRK08300 545693009146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009147 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 545693009148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 545693009149 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693009150 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 545693009151 NAD binding site [chemical binding]; other site 545693009152 catalytic residues [active] 545693009153 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 545693009154 homotrimer interaction site [polypeptide binding]; other site 545693009155 putative active site [active] 545693009156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693009157 Cupin domain; Region: Cupin_2; cl09118 545693009158 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009159 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 545693009160 active site 545693009161 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 545693009162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693009163 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 545693009164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693009165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009166 ligand binding site [chemical binding]; other site 545693009167 flexible hinge region; other site 545693009168 Helix-turn-helix domains; Region: HTH; cl00088 545693009169 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009170 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 545693009171 ligand binding site [chemical binding]; other site 545693009172 flexible hinge region; other site 545693009173 Helix-turn-helix domains; Region: HTH; cl00088 545693009174 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 545693009175 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693009176 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693009177 DNA binding residues [nucleotide binding] 545693009178 putative dimer interface [polypeptide binding]; other site 545693009179 Domain of unknown function (DUF303); Region: DUF303; pfam03629 545693009180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693009181 binding surface 545693009182 TPR motif; other site 545693009183 Tetratrico peptide repeat; Region: TPR_5; pfam12688 545693009184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693009185 binding surface 545693009186 TPR motif; other site 545693009187 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 545693009188 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 545693009189 A new structural DNA glycosylase; Region: AlkD_like; cd06561 545693009190 active site 545693009191 Protein of unknown function (DUF419); Region: DUF419; cl15265 545693009192 Protein of unknown function (DUF419); Region: DUF419; cl15265 545693009193 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 545693009194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 545693009195 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 545693009196 Probable transposase; Region: OrfB_IS605; pfam01385 545693009197 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 545693009198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 545693009199 EamA-like transporter family; Region: EamA; cl01037 545693009200 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693009201 EamA-like transporter family; Region: EamA; cl01037 545693009202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693009203 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 545693009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009205 putative substrate translocation pore; other site 545693009206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693009207 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693009208 nudix motif; other site 545693009209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009210 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693009211 DinB superfamily; Region: DinB_2; pfam12867 545693009212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 545693009213 MOSC domain; Region: MOSC; pfam03473 545693009214 3-alpha domain; Region: 3-alpha; pfam03475 545693009215 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693009216 homotrimer interaction site [polypeptide binding]; other site 545693009217 putative active site [active] 545693009218 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693009220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009222 putative substrate translocation pore; other site 545693009223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009224 Helix-turn-helix domains; Region: HTH; cl00088 545693009225 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 545693009226 putative dimerization interface [polypeptide binding]; other site 545693009227 Nitronate monooxygenase; Region: NMO; pfam03060 545693009228 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693009229 FMN binding site [chemical binding]; other site 545693009230 substrate binding site [chemical binding]; other site 545693009231 putative catalytic residue [active] 545693009232 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 545693009233 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693009234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009235 D-galactonate transporter; Region: 2A0114; TIGR00893 545693009236 putative substrate translocation pore; other site 545693009237 galactonate dehydratase; Provisional; Region: PRK14017 545693009238 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 545693009239 putative active site pocket [active] 545693009240 putative metal binding site [ion binding]; other site 545693009241 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 545693009242 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 545693009243 active site 545693009244 intersubunit interface [polypeptide binding]; other site 545693009245 catalytic residue [active] 545693009246 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 545693009247 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 545693009248 substrate binding site [chemical binding]; other site 545693009249 ATP binding site [chemical binding]; other site 545693009250 Transcriptional regulator [Transcription]; Region: IclR; COG1414 545693009251 Helix-turn-helix domains; Region: HTH; cl00088 545693009252 Bacterial transcriptional regulator; Region: IclR; pfam01614 545693009253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693009254 sequence-specific DNA binding site [nucleotide binding]; other site 545693009255 salt bridge; other site 545693009256 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693009257 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 545693009258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693009259 Walker A/P-loop; other site 545693009260 ATP binding site [chemical binding]; other site 545693009261 Q-loop/lid; other site 545693009262 ABC transporter signature motif; other site 545693009263 Walker B; other site 545693009264 D-loop; other site 545693009265 H-loop/switch region; other site 545693009266 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 545693009267 Helix-turn-helix domains; Region: HTH; cl00088 545693009268 Membrane transport protein; Region: Mem_trans; cl09117 545693009269 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693009270 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 545693009271 NAD(P) binding site [chemical binding]; other site 545693009272 catalytic residues [active] 545693009273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693009274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009275 DNA-binding site [nucleotide binding]; DNA binding site 545693009276 UTRA domain; Region: UTRA; cl01230 545693009277 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 545693009278 hexamer (dimer of trimers) interface [polypeptide binding]; other site 545693009279 substrate binding site [chemical binding]; other site 545693009280 trimer interface [polypeptide binding]; other site 545693009281 Mn binding site [ion binding]; other site 545693009282 alpha-glucosidase; Provisional; Region: PRK10426 545693009283 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 545693009284 putative active site [active] 545693009285 putative catalytic site [active] 545693009286 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693009287 active site 545693009288 intersubunit interactions; other site 545693009289 catalytic residue [active] 545693009290 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 545693009291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009292 putative substrate translocation pore; other site 545693009293 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693009294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009295 NAD(P) binding site [chemical binding]; other site 545693009296 active site 545693009297 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 545693009298 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 545693009299 putative NAD(P) binding site [chemical binding]; other site 545693009300 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693009301 classical (c) SDRs; Region: SDR_c; cd05233 545693009302 NAD(P) binding site [chemical binding]; other site 545693009303 active site 545693009304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693009305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009308 Helix-turn-helix domains; Region: HTH; cl00088 545693009309 Helix-turn-helix domains; Region: HTH; cl00088 545693009310 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009311 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 545693009312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 545693009313 ligand binding site [chemical binding]; other site 545693009314 flexible hinge region; other site 545693009315 Helix-turn-helix domains; Region: HTH; cl00088 545693009316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009317 S-adenosylmethionine binding site [chemical binding]; other site 545693009318 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 545693009319 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 545693009320 active site 1 [active] 545693009321 dimer interface [polypeptide binding]; other site 545693009322 hexamer interface [polypeptide binding]; other site 545693009323 active site 2 [active] 545693009324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009325 Helix-turn-helix domains; Region: HTH; cl00088 545693009326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009327 dimerization interface [polypeptide binding]; other site 545693009328 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693009329 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 545693009330 conserved cys residue [active] 545693009331 Helix-turn-helix domains; Region: HTH; cl00088 545693009332 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009333 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 545693009334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693009335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009336 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009337 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009338 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 545693009339 Isochorismatase family; Region: Isochorismatase; pfam00857 545693009340 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 545693009341 catalytic triad [active] 545693009342 dimer interface [polypeptide binding]; other site 545693009343 conserved cis-peptide bond; other site 545693009344 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009345 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 545693009346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693009347 Zn binding site [ion binding]; other site 545693009348 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 545693009349 Zn binding site [ion binding]; other site 545693009350 DoxX; Region: DoxX; cl00976 545693009351 malate dehydrogenase; Reviewed; Region: PRK06223 545693009352 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 545693009353 NAD(P) binding site [chemical binding]; other site 545693009354 dimer interface [polypeptide binding]; other site 545693009355 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693009356 substrate binding site [chemical binding]; other site 545693009357 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 545693009358 Hexamer interface [polypeptide binding]; other site 545693009359 Hexagonal pore residue; other site 545693009360 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 545693009361 Hexamer/Pentamer interface [polypeptide binding]; other site 545693009362 central pore; other site 545693009363 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 545693009364 Propanediol utilisation protein PduL; Region: PduL; pfam06130 545693009365 Propanediol utilisation protein PduL; Region: PduL; pfam06130 545693009366 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 545693009367 Hexamer interface [polypeptide binding]; other site 545693009368 Putative hexagonal pore residue; other site 545693009369 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 545693009370 putative catalytic cysteine [active] 545693009371 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 545693009372 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 545693009373 putative hexamer interface [polypeptide binding]; other site 545693009374 putative hexagonal pore; other site 545693009375 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 545693009376 putative hexamer interface [polypeptide binding]; other site 545693009377 putative hexagonal pore; other site 545693009378 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 545693009379 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 545693009380 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 545693009381 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 545693009382 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 545693009383 G1 box; other site 545693009384 GTP/Mg2+ binding site [chemical binding]; other site 545693009385 G2 box; other site 545693009386 Switch I region; other site 545693009387 G3 box; other site 545693009388 Switch II region; other site 545693009389 G4 box; other site 545693009390 G5 box; other site 545693009391 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 545693009392 putative hexamer interface [polypeptide binding]; other site 545693009393 putative hexagonal pore; other site 545693009394 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 545693009395 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 545693009396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693009397 active site 545693009398 phosphorylation site [posttranslational modification] 545693009399 intermolecular recognition site; other site 545693009400 dimerization interface [polypeptide binding]; other site 545693009401 ANTAR domain; Region: ANTAR; cl04297 545693009402 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 545693009403 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693009404 Histidine kinase; Region: HisKA_2; cl06527 545693009405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009406 Mg2+ binding site [ion binding]; other site 545693009407 G-X-G motif; other site 545693009408 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 545693009409 Helix-turn-helix domains; Region: HTH; cl00088 545693009410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009411 Helix-turn-helix domains; Region: HTH; cl00088 545693009412 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693009413 benzoate transport; Region: 2A0115; TIGR00895 545693009414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693009418 DNA binding site [nucleotide binding] 545693009419 domain linker motif; other site 545693009420 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693009421 dimerization interface [polypeptide binding]; other site 545693009422 ligand binding site [chemical binding]; other site 545693009423 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 545693009424 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 545693009425 inhibitor site; inhibition site 545693009426 active site 545693009427 dimer interface [polypeptide binding]; other site 545693009428 catalytic residue [active] 545693009429 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693009430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009432 Helix-turn-helix domains; Region: HTH; cl00088 545693009433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009434 dimerization interface [polypeptide binding]; other site 545693009435 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 545693009436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009437 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 545693009438 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 545693009439 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 545693009440 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 545693009441 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 545693009442 putative active site [active] 545693009443 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693009444 Citrate transporter; Region: CitMHS; pfam03600 545693009445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009446 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693009447 putative substrate translocation pore; other site 545693009448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009449 putative substrate translocation pore; other site 545693009450 Helix-turn-helix domains; Region: HTH; cl00088 545693009451 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 545693009452 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693009453 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 545693009454 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693009455 DinB superfamily; Region: DinB_2; pfam12867 545693009456 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 545693009457 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 545693009458 substrate-cofactor binding pocket; other site 545693009459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693009460 catalytic residue [active] 545693009461 Protein of unknown function (DUF452); Region: DUF452; cl01062 545693009462 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693009463 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 545693009464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009465 S-adenosylmethionine binding site [chemical binding]; other site 545693009466 Predicted transcriptional regulators [Transcription]; Region: COG1378 545693009467 Helix-turn-helix domains; Region: HTH; cl00088 545693009468 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 545693009469 C-terminal domain interface [polypeptide binding]; other site 545693009470 sugar binding site [chemical binding]; other site 545693009471 EamA-like transporter family; Region: EamA; cl01037 545693009472 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693009473 EamA-like transporter family; Region: EamA; cl01037 545693009474 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 545693009475 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 545693009476 active site 545693009477 metal binding site [ion binding]; metal-binding site 545693009478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009479 Helix-turn-helix domains; Region: HTH; cl00088 545693009480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009481 dimerization interface [polypeptide binding]; other site 545693009482 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693009483 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693009484 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 545693009485 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 545693009486 conserved cys residue [active] 545693009487 CAAX protease self-immunity; Region: Abi; cl00558 545693009488 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693009489 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 545693009490 active site 545693009491 homotetramer interface [polypeptide binding]; other site 545693009492 homodimer interface [polypeptide binding]; other site 545693009493 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 545693009494 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693009495 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 545693009496 Helix-turn-helix domains; Region: HTH; cl00088 545693009497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009498 Helix-turn-helix domains; Region: HTH; cl00088 545693009499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009500 dimerization interface [polypeptide binding]; other site 545693009501 Cyclophilin-like; Region: Cyclophil_like; cl00950 545693009502 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693009503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009504 putative substrate translocation pore; other site 545693009505 Heat induced stress protein YflT; Region: YflT; pfam11181 545693009506 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 545693009507 malate dehydrogenase; Provisional; Region: PRK13529 545693009508 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693009509 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 545693009510 NAD(P) binding site [chemical binding]; other site 545693009511 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 545693009512 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693009513 DinB superfamily; Region: DinB_2; pfam12867 545693009514 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693009515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693009516 motif II; other site 545693009517 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693009518 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693009519 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009520 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009521 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693009522 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693009523 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 545693009524 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693009525 DinB superfamily; Region: DinB_2; pfam12867 545693009526 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 545693009527 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 545693009528 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 545693009529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693009530 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 545693009531 SPW repeat; Region: SPW; pfam03779 545693009532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693009533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693009534 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693009535 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693009536 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 545693009537 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 545693009538 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009539 Helix-turn-helix domains; Region: HTH; cl00088 545693009540 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693009541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 545693009543 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693009544 YvrJ protein family; Region: YvrJ; pfam12841 545693009545 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 545693009546 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 545693009547 dimer interface [polypeptide binding]; other site 545693009548 putative functional site; other site 545693009549 putative MPT binding site; other site 545693009550 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 545693009551 trimer interface [polypeptide binding]; other site 545693009552 dimer interface [polypeptide binding]; other site 545693009553 putative active site [active] 545693009554 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 545693009555 MPT binding site; other site 545693009556 trimer interface [polypeptide binding]; other site 545693009557 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 545693009558 Moco binding site; other site 545693009559 metal coordination site [ion binding]; other site 545693009560 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693009561 TM-ABC transporter signature motif; other site 545693009562 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693009563 TM-ABC transporter signature motif; other site 545693009564 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 545693009565 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 545693009566 Walker A/P-loop; other site 545693009567 ATP binding site [chemical binding]; other site 545693009568 Q-loop/lid; other site 545693009569 ABC transporter signature motif; other site 545693009570 Walker B; other site 545693009571 D-loop; other site 545693009572 H-loop/switch region; other site 545693009573 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 545693009574 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 545693009575 ligand binding site [chemical binding]; other site 545693009576 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 545693009577 Predicted acetyltransferase [General function prediction only]; Region: COG3393 545693009578 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693009579 Putative cyclase; Region: Cyclase; cl00814 545693009580 PrpF protein; Region: PrpF; pfam04303 545693009581 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 545693009582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009583 Helix-turn-helix domains; Region: HTH; cl00088 545693009584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693009585 dimerization interface [polypeptide binding]; other site 545693009586 Citrate transporter; Region: CitMHS; pfam03600 545693009587 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693009588 transmembrane helices; other site 545693009589 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 545693009590 Clp protease; Region: CLP_protease; pfam00574 545693009591 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693009592 oligomer interface [polypeptide binding]; other site 545693009593 active site residues [active] 545693009594 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693009595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693009597 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 545693009598 NlpC/P60 family; Region: NLPC_P60; cl11438 545693009599 NlpC/P60 family; Region: NLPC_P60; cl11438 545693009600 NlpC/P60 family; Region: NLPC_P60; cl11438 545693009601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693009603 putative substrate translocation pore; other site 545693009604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693009605 Helix-turn-helix domains; Region: HTH; cl00088 545693009606 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693009607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693009609 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693009610 DNA-binding site [nucleotide binding]; DNA binding site 545693009611 RNA-binding motif; other site 545693009612 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 545693009613 putative transport protein YifK; Provisional; Region: PRK10746 545693009614 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693009615 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 545693009616 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693009617 Glutamate binding site [chemical binding]; other site 545693009618 homodimer interface [polypeptide binding]; other site 545693009619 NAD binding site [chemical binding]; other site 545693009620 catalytic residues [active] 545693009621 Proline dehydrogenase; Region: Pro_dh; cl03282 545693009622 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 545693009623 YcxB-like protein; Region: YcxB; pfam14317 545693009624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693009625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 545693009626 dimer interface [polypeptide binding]; other site 545693009627 putative metal binding site [ion binding]; other site 545693009628 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 545693009629 stage II sporulation protein P; Region: spore_II_P; TIGR02867 545693009630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693009631 PAS domain; Region: PAS_9; pfam13426 545693009632 putative active site [active] 545693009633 heme pocket [chemical binding]; other site 545693009634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 545693009635 metal binding site [ion binding]; metal-binding site 545693009636 active site 545693009637 I-site; other site 545693009638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 545693009639 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 545693009640 putative active site [active] 545693009641 putative metal binding site [ion binding]; other site 545693009642 PgaD-like protein; Region: PgaD; cl14676 545693009643 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 545693009644 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 545693009645 DXD motif; other site 545693009646 Ferritin-like domain; Region: Ferritin; pfam00210 545693009647 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 545693009648 ferroxidase diiron center [ion binding]; other site 545693009649 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693009650 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693009651 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693009652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009653 S-adenosylmethionine binding site [chemical binding]; other site 545693009654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 545693009655 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 545693009656 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 545693009657 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 545693009658 active site 545693009659 Zn binding site [ion binding]; other site 545693009660 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693009661 Phosphate-starvation-inducible E; Region: PsiE; cl01264 545693009662 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693009663 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 545693009664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693009665 active site 545693009666 catalytic tetrad [active] 545693009667 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 545693009668 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693009669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 545693009670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009671 Coenzyme A binding pocket [chemical binding]; other site 545693009672 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 545693009673 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 545693009674 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 545693009675 DNA binding residues [nucleotide binding] 545693009676 putative dimer interface [polypeptide binding]; other site 545693009677 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 545693009678 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693009679 active site 545693009680 catalytic tetrad [active] 545693009681 CAAX protease self-immunity; Region: Abi; cl00558 545693009682 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693009683 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693009684 DNA binding residues [nucleotide binding] 545693009685 dimer interface [polypeptide binding]; other site 545693009686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009687 putative substrate translocation pore; other site 545693009688 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693009689 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 545693009690 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 545693009691 substrate binding [chemical binding]; other site 545693009692 active site 545693009693 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 545693009694 YtxH-like protein; Region: YtxH; cl02079 545693009695 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 545693009696 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 545693009697 active site 545693009698 nucleophile elbow; other site 545693009699 FtsX-like permease family; Region: FtsX; cl15850 545693009700 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693009701 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693009702 Walker A/P-loop; other site 545693009703 ATP binding site [chemical binding]; other site 545693009704 Q-loop/lid; other site 545693009705 ABC transporter signature motif; other site 545693009706 Walker B; other site 545693009707 D-loop; other site 545693009708 H-loop/switch region; other site 545693009709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 545693009710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009711 ATP binding site [chemical binding]; other site 545693009712 Mg2+ binding site [ion binding]; other site 545693009713 G-X-G motif; other site 545693009714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693009715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693009716 active site 545693009717 phosphorylation site [posttranslational modification] 545693009718 intermolecular recognition site; other site 545693009719 dimerization interface [polypeptide binding]; other site 545693009720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693009721 DNA binding site [nucleotide binding] 545693009722 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 545693009723 substrate binding pocket [chemical binding]; other site 545693009724 substrate-Mg2+ binding site; other site 545693009725 aspartate-rich region 1; other site 545693009726 aspartate-rich region 2; other site 545693009727 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 545693009728 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 545693009729 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 545693009730 putative homodimer interface [polypeptide binding]; other site 545693009731 putative homotetramer interface [polypeptide binding]; other site 545693009732 putative metal binding site [ion binding]; other site 545693009733 putative homodimer-homodimer interface [polypeptide binding]; other site 545693009734 putative allosteric switch controlling residues; other site 545693009735 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 545693009736 Competence protein J (ComJ); Region: ComJ; pfam11033 545693009737 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 545693009738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693009739 Family description; Region: UvrD_C_2; cl15862 545693009740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693009741 substrate binding site [chemical binding]; other site 545693009742 oxyanion hole (OAH) forming residues; other site 545693009743 Helix-turn-helix domains; Region: HTH; cl00088 545693009744 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 545693009745 CGNR zinc finger; Region: zf-CGNR; pfam11706 545693009746 HPP family; Region: HPP; pfam04982 545693009747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693009748 DoxX; Region: DoxX; cl00976 545693009749 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 545693009750 Ligand binding site; other site 545693009751 Putative Catalytic site; other site 545693009752 DXD motif; other site 545693009753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693009754 active site 545693009755 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 545693009756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009757 NAD(P) binding site [chemical binding]; other site 545693009758 active site 545693009759 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693009760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693009762 active site 545693009763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693009764 active site 545693009765 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693009766 NlpC/P60 family; Region: NLPC_P60; cl11438 545693009767 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 545693009768 heme-binding site [chemical binding]; other site 545693009769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 545693009770 dimer interface [polypeptide binding]; other site 545693009771 putative CheW interface [polypeptide binding]; other site 545693009772 transcriptional regulator Hpr; Provisional; Region: PRK13777 545693009773 Helix-turn-helix domains; Region: HTH; cl00088 545693009774 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 545693009775 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693009776 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 545693009777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693009778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693009779 DNA binding residues [nucleotide binding] 545693009780 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 545693009781 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 545693009782 NodB motif; other site 545693009783 active site 545693009784 catalytic site [active] 545693009785 Spore germination protein; Region: Spore_permease; cl15802 545693009786 S-methylmethionine transporter; Provisional; Region: PRK11387 545693009787 Spore germination protein; Region: Spore_permease; cl15802 545693009788 Arginase family; Region: Arginase; cl00306 545693009789 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 545693009790 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 545693009791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693009792 TPR motif; other site 545693009793 binding surface 545693009794 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 545693009795 Cation transport protein; Region: TrkH; cl10514 545693009796 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 545693009797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693009798 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693009799 Uncharacterized conserved protein [Function unknown]; Region: COG2128 545693009800 Helix-turn-helix domains; Region: HTH; cl00088 545693009801 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 545693009802 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 545693009803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693009804 protein binding site [polypeptide binding]; other site 545693009805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693009806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693009807 active site 545693009808 phosphorylation site [posttranslational modification] 545693009809 intermolecular recognition site; other site 545693009810 dimerization interface [polypeptide binding]; other site 545693009811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693009812 DNA binding site [nucleotide binding] 545693009813 two-component sensor protein; Provisional; Region: cpxA; PRK09470 545693009814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693009815 dimerization interface [polypeptide binding]; other site 545693009816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693009817 dimer interface [polypeptide binding]; other site 545693009818 phosphorylation site [posttranslational modification] 545693009819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009820 ATP binding site [chemical binding]; other site 545693009821 Mg2+ binding site [ion binding]; other site 545693009822 G-X-G motif; other site 545693009823 D-cysteine desulfhydrase; Validated; Region: PRK03910 545693009824 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 545693009825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693009826 catalytic residue [active] 545693009827 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 545693009828 Transcriptional regulators [Transcription]; Region: GntR; COG1802 545693009829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009830 DNA-binding site [nucleotide binding]; DNA binding site 545693009831 FCD domain; Region: FCD; cl11656 545693009832 EamA-like transporter family; Region: EamA; cl01037 545693009833 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 545693009834 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 545693009835 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 545693009836 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 545693009837 active site 545693009838 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693009839 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693009840 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 545693009841 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693009842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693009843 ABC-ATPase subunit interface; other site 545693009844 NMT1-like family; Region: NMT1_2; cl15260 545693009845 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 545693009846 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 545693009847 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 545693009848 Walker A/P-loop; other site 545693009849 ATP binding site [chemical binding]; other site 545693009850 Q-loop/lid; other site 545693009851 ABC transporter signature motif; other site 545693009852 Walker B; other site 545693009853 D-loop; other site 545693009854 H-loop/switch region; other site 545693009855 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 545693009856 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 545693009857 iron-sulfur cluster [ion binding]; other site 545693009858 [2Fe-2S] cluster binding site [ion binding]; other site 545693009859 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 545693009860 hydrophobic ligand binding site; other site 545693009861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693009862 putative substrate translocation pore; other site 545693009863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009864 Helix-turn-helix domains; Region: HTH; cl00088 545693009865 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 545693009866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693009867 dimer interface [polypeptide binding]; other site 545693009868 conserved gate region; other site 545693009869 putative PBP binding loops; other site 545693009870 ABC-ATPase subunit interface; other site 545693009871 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 545693009872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 545693009873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693009874 dimer interface [polypeptide binding]; other site 545693009875 putative PBP binding loops; other site 545693009876 ABC-ATPase subunit interface; other site 545693009877 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 545693009878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693009879 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 545693009880 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 545693009881 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693009882 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693009883 DNA binding site [nucleotide binding] 545693009884 domain linker motif; other site 545693009885 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693009886 dimerization interface [polypeptide binding]; other site 545693009887 ligand binding site [chemical binding]; other site 545693009888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693009889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693009890 dimer interface [polypeptide binding]; other site 545693009891 phosphorylation site [posttranslational modification] 545693009892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693009893 ATP binding site [chemical binding]; other site 545693009894 Mg2+ binding site [ion binding]; other site 545693009895 G-X-G motif; other site 545693009896 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693009897 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693009898 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693009899 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 545693009900 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 545693009901 FMN binding site [chemical binding]; other site 545693009902 substrate binding site [chemical binding]; other site 545693009903 putative catalytic residue [active] 545693009904 hydroperoxidase II; Provisional; Region: katE; PRK11249 545693009905 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 545693009906 tetramer interface [polypeptide binding]; other site 545693009907 heme binding pocket [chemical binding]; other site 545693009908 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 545693009909 domain interactions; other site 545693009910 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 545693009911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009912 Coenzyme A binding pocket [chemical binding]; other site 545693009913 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693009914 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693009915 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 545693009916 Sulfatase; Region: Sulfatase; cl10460 545693009917 Cupin domain; Region: Cupin_2; cl09118 545693009918 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 545693009919 EamA-like transporter family; Region: EamA; cl01037 545693009920 EamA-like transporter family; Region: EamA; cl01037 545693009921 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 545693009922 putative active site [active] 545693009923 putative FMN binding site [chemical binding]; other site 545693009924 putative substrate binding site [chemical binding]; other site 545693009925 putative catalytic residue [active] 545693009926 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 545693009927 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 545693009928 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693009929 Protein of unknown function (DUF819); Region: DUF819; cl02317 545693009930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693009931 Helix-turn-helix domains; Region: HTH; cl00088 545693009932 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 545693009933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693009934 Helix-turn-helix domains; Region: HTH; cl00088 545693009935 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693009936 putative dimerization interface [polypeptide binding]; other site 545693009937 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 545693009938 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 545693009939 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 545693009940 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693009941 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693009942 NAD binding site [chemical binding]; other site 545693009943 substrate binding site [chemical binding]; other site 545693009944 putative active site [active] 545693009945 MgtC family; Region: MgtC; pfam02308 545693009946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693009947 S-adenosylmethionine binding site [chemical binding]; other site 545693009948 Protein of unknown function (DUF867); Region: DUF867; cl01713 545693009949 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 545693009950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693009951 DNA-binding site [nucleotide binding]; DNA binding site 545693009952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693009953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693009954 homodimer interface [polypeptide binding]; other site 545693009955 catalytic residue [active] 545693009956 Predicted acetyltransferase [General function prediction only]; Region: COG3153 545693009957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009958 Coenzyme A binding pocket [chemical binding]; other site 545693009959 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693009960 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 545693009961 Spore germination protein; Region: Spore_permease; cl15802 545693009962 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 545693009963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009964 Coenzyme A binding pocket [chemical binding]; other site 545693009965 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 545693009966 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 545693009967 Ligand binding site; other site 545693009968 Putative Catalytic site; other site 545693009969 DXD motif; other site 545693009970 GtrA-like protein; Region: GtrA; cl00971 545693009971 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693009972 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 545693009973 active site 545693009974 metal binding site [ion binding]; metal-binding site 545693009975 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 545693009976 protoporphyrinogen oxidase; Provisional; Region: PRK12416 545693009977 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 545693009978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 545693009979 putative metal binding site [ion binding]; other site 545693009980 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693009981 active site 545693009982 metal binding site [ion binding]; metal-binding site 545693009983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693009984 EamA-like transporter family; Region: EamA; cl01037 545693009985 EamA-like transporter family; Region: EamA; cl01037 545693009986 Predicted acetyltransferase [General function prediction only]; Region: COG3153 545693009987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693009988 Coenzyme A binding pocket [chemical binding]; other site 545693009989 LysE type translocator; Region: LysE; cl00565 545693009990 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 545693009991 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 545693009992 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 545693009993 Membrane transport protein; Region: Mem_trans; cl09117 545693009994 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693009995 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693009996 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 545693009997 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 545693009998 Domain of unknown function DUF21; Region: DUF21; pfam01595 545693009999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 545693010000 Transporter associated domain; Region: CorC_HlyC; cl08393 545693010001 NAD-dependent deacetylase; Provisional; Region: PRK00481 545693010002 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 545693010003 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693010004 Ligand Binding Site [chemical binding]; other site 545693010005 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 545693010006 active site 545693010007 ADP/pyrophosphate binding site [chemical binding]; other site 545693010008 dimerization interface [polypeptide binding]; other site 545693010009 allosteric effector site; other site 545693010010 fructose-1,6-bisphosphate binding site; other site 545693010011 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693010012 NlpC/P60 family; Region: NLPC_P60; cl11438 545693010013 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693010014 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 545693010015 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693010016 Spore germination protein; Region: Spore_permease; cl15802 545693010017 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693010018 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693010019 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693010020 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693010021 Walker A/P-loop; other site 545693010022 ATP binding site [chemical binding]; other site 545693010023 Q-loop/lid; other site 545693010024 ABC transporter signature motif; other site 545693010025 Walker B; other site 545693010026 D-loop; other site 545693010027 H-loop/switch region; other site 545693010028 Predicted transcriptional regulators [Transcription]; Region: COG1725 545693010029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010030 DNA-binding site [nucleotide binding]; DNA binding site 545693010031 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693010032 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 545693010033 Uncharacterized conserved protein [Function unknown]; Region: COG1284 545693010034 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 545693010035 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693010036 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010037 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010038 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 545693010039 active site 545693010040 putative catalytic site [active] 545693010041 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 545693010042 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693010043 active site 545693010044 catalytic site [active] 545693010045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693010046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010047 Walker A/P-loop; other site 545693010048 ATP binding site [chemical binding]; other site 545693010049 Q-loop/lid; other site 545693010050 ABC transporter signature motif; other site 545693010051 Walker B; other site 545693010052 D-loop; other site 545693010053 H-loop/switch region; other site 545693010054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 545693010055 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693010056 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 545693010057 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 545693010058 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 545693010059 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693010060 active site turn [active] 545693010061 phosphorylation site [posttranslational modification] 545693010062 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693010063 transcriptional antiterminator BglG; Provisional; Region: PRK09772 545693010064 CAT RNA binding domain; Region: CAT_RBD; cl03904 545693010065 PRD domain; Region: PRD; cl15445 545693010066 PRD domain; Region: PRD; cl15445 545693010067 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 545693010068 HPr interaction site; other site 545693010069 glycerol kinase (GK) interaction site [polypeptide binding]; other site 545693010070 active site 545693010071 phosphorylation site [posttranslational modification] 545693010072 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693010073 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 545693010074 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 545693010075 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693010076 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693010077 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 545693010078 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693010079 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 545693010080 YodL-like; Region: YodL; pfam14191 545693010081 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 545693010082 active site 545693010083 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 545693010084 SpoOM protein; Region: Spo0M; pfam07070 545693010085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 545693010086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 545693010087 active site 545693010088 ATP binding site [chemical binding]; other site 545693010089 substrate binding site [chemical binding]; other site 545693010090 activation loop (A-loop); other site 545693010091 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 545693010092 YozD-like protein; Region: YozD; pfam14162 545693010093 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 545693010094 OpgC protein; Region: OpgC_C; cl00792 545693010095 Acyltransferase family; Region: Acyl_transf_3; pfam01757 545693010096 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 545693010097 homodimer interface [polypeptide binding]; other site 545693010098 substrate-cofactor binding pocket; other site 545693010099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010100 catalytic residue [active] 545693010101 YokU-like protein; Region: YokU; cl15819 545693010102 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 545693010103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693010104 FeS/SAM binding site; other site 545693010105 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 545693010106 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 545693010107 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693010108 acetylornithine deacetylase; Validated; Region: PRK06915 545693010109 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 545693010110 metal binding site [ion binding]; metal-binding site 545693010111 dimer interface [polypeptide binding]; other site 545693010112 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693010113 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693010114 hypothetical protein; Provisional; Region: PRK06917 545693010115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010116 inhibitor-cofactor binding pocket; inhibition site 545693010117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010118 catalytic residue [active] 545693010119 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 545693010120 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 545693010121 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 545693010122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010123 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693010124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010125 putative active site [active] 545693010126 heme pocket [chemical binding]; other site 545693010127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010128 dimer interface [polypeptide binding]; other site 545693010129 phosphorylation site [posttranslational modification] 545693010130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010131 ATP binding site [chemical binding]; other site 545693010132 Mg2+ binding site [ion binding]; other site 545693010133 G-X-G motif; other site 545693010134 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010135 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 545693010136 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 545693010137 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 545693010138 active site 545693010139 catalytic triad [active] 545693010140 oxyanion hole [active] 545693010141 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 545693010142 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 545693010143 Cu(I) binding site [ion binding]; other site 545693010144 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693010145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693010146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010147 dimer interface [polypeptide binding]; other site 545693010148 phosphorylation site [posttranslational modification] 545693010149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010150 ATP binding site [chemical binding]; other site 545693010151 Mg2+ binding site [ion binding]; other site 545693010152 G-X-G motif; other site 545693010153 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 545693010154 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 545693010155 threonine dehydratase; Validated; Region: PRK08639 545693010156 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 545693010157 tetramer interface [polypeptide binding]; other site 545693010158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010159 catalytic residue [active] 545693010160 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 545693010161 putative Ile/Val binding site [chemical binding]; other site 545693010162 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 545693010163 folate binding site [chemical binding]; other site 545693010164 NADP+ binding site [chemical binding]; other site 545693010165 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 545693010166 dimerization interface [polypeptide binding]; other site 545693010167 active site 545693010168 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 545693010169 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 545693010170 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 545693010171 putative active site [active] 545693010172 putative substrate binding site [chemical binding]; other site 545693010173 putative cosubstrate binding site; other site 545693010174 catalytic site [active] 545693010175 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 545693010176 IucA / IucC family; Region: IucA_IucC; pfam04183 545693010177 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693010178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693010179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693010180 putative substrate translocation pore; other site 545693010181 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 545693010182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 545693010183 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 545693010184 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 545693010185 IucA / IucC family; Region: IucA_IucC; pfam04183 545693010186 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693010187 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 545693010188 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 545693010189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010190 catalytic residue [active] 545693010191 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 545693010192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010193 inhibitor-cofactor binding pocket; inhibition site 545693010194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010195 catalytic residue [active] 545693010196 CutC family; Region: CutC; cl01218 545693010197 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 545693010198 DNA photolyase; Region: DNA_photolyase; pfam00875 545693010199 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 545693010200 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 545693010201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 545693010202 putative active site [active] 545693010203 heme pocket [chemical binding]; other site 545693010204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693010205 dimer interface [polypeptide binding]; other site 545693010206 phosphorylation site [posttranslational modification] 545693010207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010208 ATP binding site [chemical binding]; other site 545693010209 Mg2+ binding site [ion binding]; other site 545693010210 G-X-G motif; other site 545693010211 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 545693010212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693010213 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 545693010214 tetramerization interface [polypeptide binding]; other site 545693010215 NAD(P) binding site [chemical binding]; other site 545693010216 catalytic residues [active] 545693010217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693010218 PAS domain; Region: PAS_9; pfam13426 545693010219 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 545693010220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693010221 Walker A motif; other site 545693010222 ATP binding site [chemical binding]; other site 545693010223 Walker B motif; other site 545693010224 arginine finger; other site 545693010225 Helix-turn-helix domains; Region: HTH; cl00088 545693010226 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 545693010227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693010228 inhibitor-cofactor binding pocket; inhibition site 545693010229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693010230 catalytic residue [active] 545693010231 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 545693010232 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 545693010233 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 545693010234 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 545693010235 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693010236 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 545693010237 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693010238 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 545693010239 Walker A/P-loop; other site 545693010240 ATP binding site [chemical binding]; other site 545693010241 Q-loop/lid; other site 545693010242 ABC transporter signature motif; other site 545693010243 Walker B; other site 545693010244 D-loop; other site 545693010245 H-loop/switch region; other site 545693010246 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 545693010247 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693010248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010249 Walker A/P-loop; other site 545693010250 ATP binding site [chemical binding]; other site 545693010251 Q-loop/lid; other site 545693010252 ABC transporter signature motif; other site 545693010253 Walker B; other site 545693010254 D-loop; other site 545693010255 H-loop/switch region; other site 545693010256 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 545693010257 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 545693010258 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 545693010259 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 545693010260 TPP-binding site [chemical binding]; other site 545693010261 dimer interface [polypeptide binding]; other site 545693010262 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693010263 PYR/PP interface [polypeptide binding]; other site 545693010264 dimer interface [polypeptide binding]; other site 545693010265 TPP binding site [chemical binding]; other site 545693010266 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693010267 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 545693010268 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 545693010269 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 545693010270 catalytic residues [active] 545693010271 catalytic nucleophile [active] 545693010272 cell division suppressor protein YneA; Provisional; Region: PRK14125 545693010273 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 545693010274 LexA repressor; Validated; Region: PRK00215 545693010275 Helix-turn-helix domains; Region: HTH; cl00088 545693010276 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 545693010277 Catalytic site [active] 545693010278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693010279 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 545693010280 Cation efflux family; Region: Cation_efflux; cl00316 545693010281 Amino acid permease; Region: AA_permease_2; pfam13520 545693010282 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693010283 active site 545693010284 metal binding site [ion binding]; metal-binding site 545693010285 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693010286 putative peptidoglycan binding site; other site 545693010287 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693010288 glutamine synthetase, type I; Region: GlnA; TIGR00653 545693010289 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 545693010290 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 545693010291 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 545693010292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693010293 DNA binding residues [nucleotide binding] 545693010294 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 545693010295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693010296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693010297 catalytic residue [active] 545693010298 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 545693010299 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 545693010300 HflX GTPase family; Region: HflX; cd01878 545693010301 G1 box; other site 545693010302 GTP/Mg2+ binding site [chemical binding]; other site 545693010303 Switch I region; other site 545693010304 G2 box; other site 545693010305 G3 box; other site 545693010306 Switch II region; other site 545693010307 G4 box; other site 545693010308 G5 box; other site 545693010309 Predicted membrane protein [Function unknown]; Region: COG2860 545693010310 UPF0126 domain; Region: UPF0126; pfam03458 545693010311 UPF0126 domain; Region: UPF0126; pfam03458 545693010312 stage V sporulation protein K; Region: spore_V_K; TIGR02881 545693010313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693010314 Walker A motif; other site 545693010315 ATP binding site [chemical binding]; other site 545693010316 Walker B motif; other site 545693010317 arginine finger; other site 545693010318 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 545693010319 Sm1 motif; other site 545693010320 intra - hexamer interaction site; other site 545693010321 inter - hexamer interaction site [polypeptide binding]; other site 545693010322 nucleotide binding pocket [chemical binding]; other site 545693010323 Sm2 motif; other site 545693010324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010325 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 545693010326 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 545693010327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010328 ATP binding site [chemical binding]; other site 545693010329 Mg2+ binding site [ion binding]; other site 545693010330 G-X-G motif; other site 545693010331 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 545693010332 ATP binding site [chemical binding]; other site 545693010333 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 545693010334 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 545693010335 MutS domain I; Region: MutS_I; pfam01624 545693010336 MutS domain II; Region: MutS_II; pfam05188 545693010337 MutS family domain IV; Region: MutS_IV; pfam05190 545693010338 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 545693010339 Walker A/P-loop; other site 545693010340 ATP binding site [chemical binding]; other site 545693010341 Q-loop/lid; other site 545693010342 ABC transporter signature motif; other site 545693010343 Walker B; other site 545693010344 D-loop; other site 545693010345 H-loop/switch region; other site 545693010346 amino acid transporter; Region: 2A0306; TIGR00909 545693010347 Spore germination protein; Region: Spore_permease; cl15802 545693010348 Spore germination protein; Region: Spore_permease; cl15802 545693010349 Outer spore coat protein E (CotE); Region: CotE; pfam10628 545693010350 Protein of unknown function (DUF964); Region: DUF964; cl01483 545693010351 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 545693010352 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 545693010353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693010354 FeS/SAM binding site; other site 545693010355 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 545693010356 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 545693010357 TPP-binding site [chemical binding]; other site 545693010358 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 545693010359 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 545693010360 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 545693010361 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 545693010362 dimer interface [polypeptide binding]; other site 545693010363 PYR/PP interface [polypeptide binding]; other site 545693010364 TPP binding site [chemical binding]; other site 545693010365 substrate binding site [chemical binding]; other site 545693010366 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 545693010367 active site 545693010368 dimer interface [polypeptide binding]; other site 545693010369 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 545693010370 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 545693010371 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693010372 putative active site [active] 545693010373 metal binding site [ion binding]; metal-binding site 545693010374 homodimer binding site [polypeptide binding]; other site 545693010375 phosphodiesterase; Provisional; Region: PRK12704 545693010376 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693010377 recombinase A; Provisional; Region: recA; PRK09354 545693010378 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 545693010379 hexamer interface [polypeptide binding]; other site 545693010380 Walker A motif; other site 545693010381 ATP binding site [chemical binding]; other site 545693010382 Walker B motif; other site 545693010383 competence damage-inducible protein A; Provisional; Region: PRK00549 545693010384 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 545693010385 putative MPT binding site; other site 545693010386 Competence-damaged protein; Region: CinA; cl00666 545693010387 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693010388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693010389 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 545693010390 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 545693010391 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 545693010392 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 545693010393 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693010394 classical (c) SDRs; Region: SDR_c; cd05233 545693010395 NAD(P) binding site [chemical binding]; other site 545693010396 active site 545693010397 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 545693010398 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 545693010399 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010400 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010401 Vps23 core domain; Region: Vps23_core; pfam09454 545693010402 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010403 TM-ABC transporter signature motif; other site 545693010404 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 545693010405 TM-ABC transporter signature motif; other site 545693010406 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 545693010407 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 545693010408 Walker A/P-loop; other site 545693010409 ATP binding site [chemical binding]; other site 545693010410 Q-loop/lid; other site 545693010411 ABC transporter signature motif; other site 545693010412 Walker B; other site 545693010413 D-loop; other site 545693010414 H-loop/switch region; other site 545693010415 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 545693010416 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 545693010417 ligand binding site [chemical binding]; other site 545693010418 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 545693010419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693010420 DNA-binding site [nucleotide binding]; DNA binding site 545693010421 UTRA domain; Region: UTRA; cl01230 545693010422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010423 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 545693010424 YlzJ-like protein; Region: YlzJ; pfam14035 545693010425 Clp protease; Region: CLP_protease; pfam00574 545693010426 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 545693010427 active site 545693010428 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 545693010429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693010430 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 545693010431 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 545693010432 dihydrodipicolinate synthase; Region: dapA; TIGR00674 545693010433 dimer interface [polypeptide binding]; other site 545693010434 active site 545693010435 catalytic residue [active] 545693010436 aspartate kinase I; Reviewed; Region: PRK08210 545693010437 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 545693010438 nucleotide binding site [chemical binding]; other site 545693010439 substrate binding site [chemical binding]; other site 545693010440 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 545693010441 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 545693010442 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 545693010443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010444 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 545693010445 Flavoprotein; Region: Flavoprotein; cl08021 545693010446 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 545693010447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010448 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 545693010449 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 545693010450 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 545693010451 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 545693010452 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 545693010453 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 545693010454 NodB motif; other site 545693010455 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 545693010456 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 545693010457 RNase E interface [polypeptide binding]; other site 545693010458 trimer interface [polypeptide binding]; other site 545693010459 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 545693010460 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 545693010461 RNase E interface [polypeptide binding]; other site 545693010462 trimer interface [polypeptide binding]; other site 545693010463 active site 545693010464 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 545693010465 putative nucleic acid binding region [nucleotide binding]; other site 545693010466 G-X-X-G motif; other site 545693010467 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 545693010468 RNA binding site [nucleotide binding]; other site 545693010469 domain interface; other site 545693010470 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 545693010471 16S/18S rRNA binding site [nucleotide binding]; other site 545693010472 S13e-L30e interaction site [polypeptide binding]; other site 545693010473 25S rRNA binding site [nucleotide binding]; other site 545693010474 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 545693010475 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 545693010476 active site 545693010477 Riboflavin kinase; Region: Flavokinase; cl03312 545693010478 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 545693010479 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 545693010480 RNA binding site [nucleotide binding]; other site 545693010481 active site 545693010482 Ribosome-binding factor A; Region: RBFA; cl00542 545693010483 Protein of unknown function (DUF503); Region: DUF503; cl00669 545693010484 translation initiation factor IF-2; Region: IF-2; TIGR00487 545693010485 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 545693010486 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 545693010487 G1 box; other site 545693010488 putative GEF interaction site [polypeptide binding]; other site 545693010489 GTP/Mg2+ binding site [chemical binding]; other site 545693010490 Switch I region; other site 545693010491 G2 box; other site 545693010492 G3 box; other site 545693010493 Switch II region; other site 545693010494 G4 box; other site 545693010495 G5 box; other site 545693010496 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 545693010497 Translation-initiation factor 2; Region: IF-2; pfam11987 545693010498 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 545693010499 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 545693010500 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 545693010501 putative RNA binding cleft [nucleotide binding]; other site 545693010502 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 545693010503 NusA N-terminal domain; Region: NusA_N; pfam08529 545693010504 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 545693010505 RNA binding site [nucleotide binding]; other site 545693010506 homodimer interface [polypeptide binding]; other site 545693010507 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 545693010508 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 545693010509 G-X-X-G motif; other site 545693010510 ribosome maturation protein RimP; Reviewed; Region: PRK00092 545693010511 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 545693010512 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 545693010513 Sm1 motif; other site 545693010514 predicted subunit interaction site [polypeptide binding]; other site 545693010515 RNA binding pocket [nucleotide binding]; other site 545693010516 Sm2 motif; other site 545693010517 DNA polymerase III PolC; Validated; Region: polC; PRK00448 545693010518 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 545693010519 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 545693010520 generic binding surface II; other site 545693010521 generic binding surface I; other site 545693010522 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 545693010523 active site 545693010524 catalytic site [active] 545693010525 substrate binding site [chemical binding]; other site 545693010526 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 545693010527 prolyl-tRNA synthetase; Provisional; Region: PRK09194 545693010528 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 545693010529 dimer interface [polypeptide binding]; other site 545693010530 motif 1; other site 545693010531 active site 545693010532 motif 2; other site 545693010533 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 545693010534 putative deacylase active site [active] 545693010535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 545693010536 active site 545693010537 motif 3; other site 545693010538 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 545693010539 anticodon binding site; other site 545693010540 RIP metalloprotease RseP; Region: TIGR00054 545693010541 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 545693010542 active site 545693010543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 545693010544 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 545693010545 protein binding site [polypeptide binding]; other site 545693010546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 545693010547 putative substrate binding region [chemical binding]; other site 545693010548 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 545693010549 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 545693010550 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 545693010551 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 545693010552 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 545693010553 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 545693010554 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 545693010555 catalytic residue [active] 545693010556 putative FPP diphosphate binding site; other site 545693010557 putative FPP binding hydrophobic cleft; other site 545693010558 dimer interface [polypeptide binding]; other site 545693010559 putative IPP diphosphate binding site; other site 545693010560 ribosome recycling factor; Reviewed; Region: frr; PRK00083 545693010561 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 545693010562 hinge region; other site 545693010563 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 545693010564 putative nucleotide binding site [chemical binding]; other site 545693010565 uridine monophosphate binding site [chemical binding]; other site 545693010566 homohexameric interface [polypeptide binding]; other site 545693010567 elongation factor Ts; Provisional; Region: tsf; PRK09377 545693010568 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 545693010569 Elongation factor TS; Region: EF_TS; pfam00889 545693010570 Elongation factor TS; Region: EF_TS; pfam00889 545693010571 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 545693010572 rRNA interaction site [nucleotide binding]; other site 545693010573 S8 interaction site; other site 545693010574 putative laminin-1 binding site; other site 545693010575 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 545693010576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010577 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693010578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693010579 DNA binding residues [nucleotide binding] 545693010580 CheD chemotactic sensory transduction; Region: CheD; cl00810 545693010581 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 545693010582 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 545693010583 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 545693010584 putative binding surface; other site 545693010585 active site 545693010586 P2 response regulator binding domain; Region: P2; pfam07194 545693010587 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 545693010588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693010589 ATP binding site [chemical binding]; other site 545693010590 Mg2+ binding site [ion binding]; other site 545693010591 G-X-G motif; other site 545693010592 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 545693010593 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 545693010594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693010595 active site 545693010596 phosphorylation site [posttranslational modification] 545693010597 intermolecular recognition site; other site 545693010598 dimerization interface [polypeptide binding]; other site 545693010599 CheB methylesterase; Region: CheB_methylest; pfam01339 545693010600 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 545693010601 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 545693010602 P-loop; other site 545693010603 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 545693010604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010605 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 545693010606 FHIPEP family; Region: FHIPEP; pfam00771 545693010607 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 545693010608 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 545693010609 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 545693010610 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 545693010611 FliP family; Region: FliP; cl00593 545693010612 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 545693010613 Response regulator receiver domain; Region: Response_reg; pfam00072 545693010614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693010615 active site 545693010616 phosphorylation site [posttranslational modification] 545693010617 intermolecular recognition site; other site 545693010618 dimerization interface [polypeptide binding]; other site 545693010619 flagellar motor switch protein; Validated; Region: PRK08119 545693010620 Chemotaxis phosphatase CheX; Region: CheX; cl15816 545693010621 Chemotaxis phosphatase CheX; Region: CheX; cl15816 545693010622 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 545693010623 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 545693010624 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 545693010625 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 545693010626 Flagellar protein (FlbD); Region: FlbD; cl00683 545693010627 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 545693010628 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693010629 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 545693010630 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 545693010631 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 545693010632 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 545693010633 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 545693010634 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 545693010635 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 545693010636 MgtE intracellular N domain; Region: MgtE_N; cl15244 545693010637 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 545693010638 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 545693010639 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 545693010640 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 545693010641 Walker A motif/ATP binding site; other site 545693010642 Walker B motif; other site 545693010643 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 545693010644 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 545693010645 FliG C-terminal domain; Region: FliG_C; pfam01706 545693010646 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 545693010647 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 545693010648 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 545693010649 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 545693010650 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 545693010651 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693010652 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 545693010653 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 545693010654 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693010655 transcriptional repressor CodY; Validated; Region: PRK04158 545693010656 CodY GAF-like domain; Region: CodY; pfam06018 545693010657 Helix-turn-helix domains; Region: HTH; cl00088 545693010658 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 545693010659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693010660 Walker A motif; other site 545693010661 ATP binding site [chemical binding]; other site 545693010662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010663 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 545693010664 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 545693010665 active site 545693010666 HslU subunit interaction site [polypeptide binding]; other site 545693010667 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 545693010668 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 545693010669 active site 545693010670 Int/Topo IB signature motif; other site 545693010671 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 545693010672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010673 DNA topoisomerase I; Validated; Region: PRK05582 545693010674 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 545693010675 active site 545693010676 interdomain interaction site; other site 545693010677 putative metal-binding site [ion binding]; other site 545693010678 nucleotide binding site [chemical binding]; other site 545693010679 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 545693010680 domain I; other site 545693010681 DNA binding groove [nucleotide binding] 545693010682 phosphate binding site [ion binding]; other site 545693010683 domain II; other site 545693010684 domain III; other site 545693010685 nucleotide binding site [chemical binding]; other site 545693010686 catalytic site [active] 545693010687 domain IV; other site 545693010688 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 545693010689 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 545693010690 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 545693010691 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 545693010692 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 545693010693 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 545693010694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010695 CoA-ligase; Region: Ligase_CoA; cl02894 545693010696 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 545693010697 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693010698 CoA-ligase; Region: Ligase_CoA; cl02894 545693010699 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 545693010700 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693010701 active site 545693010702 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 545693010703 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 545693010704 GTP/Mg2+ binding site [chemical binding]; other site 545693010705 G4 box; other site 545693010706 G5 box; other site 545693010707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693010708 G1 box; other site 545693010709 Switch I region; other site 545693010710 G2 box; other site 545693010711 G3 box; other site 545693010712 Switch II region; other site 545693010713 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 545693010714 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 545693010715 Catalytic site [active] 545693010716 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 545693010717 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 545693010718 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 545693010719 RimM N-terminal domain; Region: RimM; pfam01782 545693010720 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 545693010721 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 545693010722 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 545693010723 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 545693010724 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 545693010725 signal recognition particle protein; Provisional; Region: PRK10867 545693010726 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 545693010727 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 545693010728 P loop; other site 545693010729 GTP binding site [chemical binding]; other site 545693010730 Signal peptide binding domain; Region: SRP_SPB; pfam02978 545693010731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693010732 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 545693010733 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 545693010734 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 545693010735 P loop; other site 545693010736 GTP binding site [chemical binding]; other site 545693010737 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 545693010738 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 545693010739 Walker A/P-loop; other site 545693010740 ATP binding site [chemical binding]; other site 545693010741 Q-loop/lid; other site 545693010742 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 545693010743 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 545693010744 ABC transporter signature motif; other site 545693010745 Walker B; other site 545693010746 D-loop; other site 545693010747 H-loop/switch region; other site 545693010748 ribonuclease III; Reviewed; Region: rnc; PRK00102 545693010749 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 545693010750 dimerization interface [polypeptide binding]; other site 545693010751 active site 545693010752 metal binding site [ion binding]; metal-binding site 545693010753 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 545693010754 dsRNA binding site [nucleotide binding]; other site 545693010755 Phosphopantetheine attachment site; Region: PP-binding; cl09936 545693010756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693010757 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693010758 NAD(P) binding site [chemical binding]; other site 545693010759 homotetramer interface [polypeptide binding]; other site 545693010760 homodimer interface [polypeptide binding]; other site 545693010761 active site 545693010762 Acyl transferase domain; Region: Acyl_transf_1; cl08282 545693010763 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 545693010764 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 545693010765 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 545693010766 Helix-turn-helix domains; Region: HTH; cl00088 545693010767 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 545693010768 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 545693010769 Y-family of DNA polymerases; Region: PolY; cl12025 545693010770 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 545693010771 generic binding surface II; other site 545693010772 ssDNA binding site; other site 545693010773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693010774 ATP binding site [chemical binding]; other site 545693010775 putative Mg++ binding site [ion binding]; other site 545693010776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693010777 nucleotide binding region [chemical binding]; other site 545693010778 ATP-binding site [chemical binding]; other site 545693010779 L-serine dehydratase, iron-sulfur-dependent, alpha subunit, frameshift 545693010780 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 545693010781 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 545693010782 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 545693010783 putative L-serine binding site [chemical binding]; other site 545693010784 putative regulatory protein, frameshift 545693010785 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 545693010786 DAK2 domain; Region: Dak2; cl03685 545693010787 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 545693010788 Asp23 family; Region: Asp23; cl00574 545693010789 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 545693010790 Thiamine pyrophosphokinase; Region: TPK; cd07995 545693010791 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 545693010792 active site 545693010793 dimerization interface [polypeptide binding]; other site 545693010794 thiamine binding site [chemical binding]; other site 545693010795 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 545693010796 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 545693010797 substrate binding site [chemical binding]; other site 545693010798 hexamer interface [polypeptide binding]; other site 545693010799 metal binding site [ion binding]; metal-binding site 545693010800 GTPase RsgA; Reviewed; Region: PRK00098 545693010801 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 545693010802 RNA binding site [nucleotide binding]; other site 545693010803 homodimer interface [polypeptide binding]; other site 545693010804 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 545693010805 GTPase/Zn-binding domain interface [polypeptide binding]; other site 545693010806 GTP/Mg2+ binding site [chemical binding]; other site 545693010807 G4 box; other site 545693010808 G5 box; other site 545693010809 G1 box; other site 545693010810 Switch I region; other site 545693010811 G2 box; other site 545693010812 G3 box; other site 545693010813 Switch II region; other site 545693010814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 545693010815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 545693010816 active site 545693010817 ATP binding site [chemical binding]; other site 545693010818 substrate binding site [chemical binding]; other site 545693010819 activation loop (A-loop); other site 545693010820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 545693010821 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693010822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693010823 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 545693010824 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 545693010825 Protein phosphatase 2C; Region: PP2C; pfam00481 545693010826 active site 545693010827 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 545693010828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693010829 FeS/SAM binding site; other site 545693010830 16S rRNA methyltransferase B; Provisional; Region: PRK14902 545693010831 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 545693010832 putative RNA binding site [nucleotide binding]; other site 545693010833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693010834 S-adenosylmethionine binding site [chemical binding]; other site 545693010835 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 545693010836 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 545693010837 putative active site [active] 545693010838 substrate binding site [chemical binding]; other site 545693010839 putative cosubstrate binding site; other site 545693010840 catalytic site [active] 545693010841 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 545693010842 substrate binding site [chemical binding]; other site 545693010843 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 545693010844 active site 545693010845 catalytic residues [active] 545693010846 metal binding site [ion binding]; metal-binding site 545693010847 primosome assembly protein PriA; Validated; Region: PRK05580 545693010848 primosome assembly protein PriA; Validated; Region: PRK05580 545693010849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693010850 ATP binding site [chemical binding]; other site 545693010851 putative Mg++ binding site [ion binding]; other site 545693010852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693010853 nucleotide binding region [chemical binding]; other site 545693010854 ATP-binding site [chemical binding]; other site 545693010855 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 545693010856 Flavoprotein; Region: Flavoprotein; cl08021 545693010857 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 545693010858 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 545693010859 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 545693010860 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 545693010861 catalytic site [active] 545693010862 G-X2-G-X-G-K; other site 545693010863 hypothetical protein; Provisional; Region: PRK11820 545693010864 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 545693010865 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 545693010866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 545693010867 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 545693010868 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 545693010869 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 545693010870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693010871 motif II; other site 545693010872 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 545693010873 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 545693010874 Domain of unknown function (DUF814); Region: DUF814; pfam05670 545693010875 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 545693010876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693010877 active site 545693010878 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 545693010879 active site 545693010880 dimer interface [polypeptide binding]; other site 545693010881 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 545693010882 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 545693010883 heterodimer interface [polypeptide binding]; other site 545693010884 active site 545693010885 FMN binding site [chemical binding]; other site 545693010886 homodimer interface [polypeptide binding]; other site 545693010887 substrate binding site [chemical binding]; other site 545693010888 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 545693010889 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 545693010890 FAD binding pocket [chemical binding]; other site 545693010891 FAD binding motif [chemical binding]; other site 545693010892 phosphate binding motif [ion binding]; other site 545693010893 beta-alpha-beta structure motif; other site 545693010894 NAD binding pocket [chemical binding]; other site 545693010895 Iron coordination center [ion binding]; other site 545693010896 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 545693010897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693010898 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693010899 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 545693010900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693010901 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693010902 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 545693010903 IMP binding site; other site 545693010904 dimer interface [polypeptide binding]; other site 545693010905 interdomain contacts; other site 545693010906 partial ornithine binding site; other site 545693010907 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 545693010908 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 545693010909 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 545693010910 catalytic site [active] 545693010911 subunit interface [polypeptide binding]; other site 545693010912 dihydroorotase; Validated; Region: pyrC; PRK09357 545693010913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 545693010914 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 545693010915 active site 545693010916 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 545693010917 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 545693010918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010919 uracil transporter; Provisional; Region: PRK10720 545693010920 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 545693010921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693010922 active site 545693010923 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 545693010924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693010925 RNA binding surface [nucleotide binding]; other site 545693010926 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 545693010927 active site 545693010928 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 545693010929 lipoprotein signal peptidase; Provisional; Region: PRK14787 545693010930 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 545693010931 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 545693010932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 545693010933 active site 545693010934 HIGH motif; other site 545693010935 nucleotide binding site [chemical binding]; other site 545693010936 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693010937 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 545693010938 active site 545693010939 KMSKS motif; other site 545693010940 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 545693010941 tRNA binding surface [nucleotide binding]; other site 545693010942 anticodon binding site; other site 545693010943 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 545693010944 DivIVA protein; Region: DivIVA; pfam05103 545693010945 DivIVA domain; Region: DivI1A_domain; TIGR03544 545693010946 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 545693010947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693010948 RNA binding surface [nucleotide binding]; other site 545693010949 YGGT family; Region: YGGT; cl00508 545693010950 Protein of unknown function (DUF552); Region: DUF552; cl00775 545693010951 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 545693010952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693010953 catalytic residue [active] 545693010954 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 545693010955 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 545693010956 sporulation sigma factor SigG; Reviewed; Region: PRK08215 545693010957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010958 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693010959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693010960 DNA binding residues [nucleotide binding] 545693010961 sporulation sigma factor SigE; Reviewed; Region: PRK08301 545693010962 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693010963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693010964 DNA binding residues [nucleotide binding] 545693010965 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 545693010966 cell division protein FtsZ; Validated; Region: PRK09330 545693010967 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 545693010968 nucleotide binding site [chemical binding]; other site 545693010969 SulA interaction site; other site 545693010970 cell division protein FtsA; Region: ftsA; TIGR01174 545693010971 Cell division protein FtsA; Region: FtsA; cl11496 545693010972 Cell division protein FtsA; Region: FtsA; cl11496 545693010973 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 545693010974 Cell division protein FtsQ; Region: FtsQ; pfam03799 545693010975 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 545693010976 FAD binding domain; Region: FAD_binding_4; pfam01565 545693010977 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 545693010978 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 545693010979 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 545693010980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693010981 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693010982 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693010983 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 545693010984 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 545693010985 Mg++ binding site [ion binding]; other site 545693010986 putative catalytic motif [active] 545693010987 putative substrate binding site [chemical binding]; other site 545693010988 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 545693010989 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693010990 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693010991 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693010992 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 545693010993 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693010994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693010995 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 545693010996 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 545693010997 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693010998 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693010999 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 545693011000 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 545693011001 Septum formation initiator; Region: DivIC; cl11433 545693011002 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 545693011003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011004 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 545693011005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 545693011006 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 545693011007 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 545693011008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011009 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 545693011010 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 545693011011 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693011012 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693011013 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693011014 carboxyltransferase (CT) interaction site; other site 545693011015 biotinylation site [posttranslational modification]; other site 545693011016 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 545693011017 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693011018 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693011019 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 545693011020 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693011021 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 545693011022 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 545693011023 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 545693011024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693011025 substrate binding site [chemical binding]; other site 545693011026 oxyanion hole (OAH) forming residues; other site 545693011027 trimer interface [polypeptide binding]; other site 545693011028 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 545693011029 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 545693011030 hypothetical protein; Provisional; Region: PRK13670 545693011031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 545693011032 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 545693011033 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 545693011034 protein binding site [polypeptide binding]; other site 545693011035 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 545693011036 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 545693011037 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 545693011038 active site 545693011039 nucleophile elbow; other site 545693011040 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 545693011041 Nucleoside recognition; Region: Gate; cl00486 545693011042 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 545693011043 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 545693011044 active site 545693011045 (T/H)XGH motif; other site 545693011046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011047 S-adenosylmethionine binding site [chemical binding]; other site 545693011048 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 545693011049 Protein of unknown function (DUF964); Region: DUF964; cl01483 545693011050 YlbE-like protein; Region: YlbE; pfam14003 545693011051 Putative coat protein; Region: YlbD_coat; pfam14071 545693011052 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 545693011053 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 545693011054 Cytochrome c; Region: Cytochrom_C; cl11414 545693011055 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 545693011056 interchain domain interface [polypeptide binding]; other site 545693011057 intrachain domain interface; other site 545693011058 heme bH binding site [chemical binding]; other site 545693011059 Qi binding site; other site 545693011060 heme bL binding site [chemical binding]; other site 545693011061 Qo binding site; other site 545693011062 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 545693011063 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 545693011064 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 545693011065 iron-sulfur cluster [ion binding]; other site 545693011066 [2Fe-2S] cluster binding site [ion binding]; other site 545693011067 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 545693011068 hypothetical protein; Provisional; Region: PRK03636 545693011069 UPF0302 domain; Region: UPF0302; pfam08864 545693011070 IDEAL domain; Region: IDEAL; cl07452 545693011071 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 545693011072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 545693011073 binding surface 545693011074 TPR motif; other site 545693011075 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 545693011076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011077 binding surface 545693011078 TPR motif; other site 545693011079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011080 binding surface 545693011081 TPR repeat; Region: TPR_11; pfam13414 545693011082 TPR motif; other site 545693011083 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 545693011084 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 545693011085 hinge; other site 545693011086 active site 545693011087 prephenate dehydrogenase; Validated; Region: PRK06545 545693011088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011089 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 545693011090 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 545693011091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693011092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011093 homodimer interface [polypeptide binding]; other site 545693011094 catalytic residue [active] 545693011095 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 545693011096 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 545693011097 substrate binding site [chemical binding]; other site 545693011098 active site 545693011099 catalytic residues [active] 545693011100 heterodimer interface [polypeptide binding]; other site 545693011101 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 545693011102 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 545693011103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011104 catalytic residue [active] 545693011105 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 545693011106 active site 545693011107 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 545693011108 active site 545693011109 ribulose/triose binding site [chemical binding]; other site 545693011110 phosphate binding site [ion binding]; other site 545693011111 substrate (anthranilate) binding pocket [chemical binding]; other site 545693011112 product (indole) binding pocket [chemical binding]; other site 545693011113 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 545693011114 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 545693011115 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 545693011116 anthranilate synthase component I; Provisional; Region: PRK13569 545693011117 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 545693011118 chorismate binding enzyme; Region: Chorismate_bind; cl10555 545693011119 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 545693011120 active site 545693011121 dimer interface [polypeptide binding]; other site 545693011122 metal binding site [ion binding]; metal-binding site 545693011123 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 545693011124 Tetramer interface [polypeptide binding]; other site 545693011125 active site 545693011126 FMN-binding site [chemical binding]; other site 545693011127 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 545693011128 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 545693011129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011130 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 545693011131 active site 545693011132 multimer interface [polypeptide binding]; other site 545693011133 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 545693011134 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 545693011135 substrate binding pocket [chemical binding]; other site 545693011136 chain length determination region; other site 545693011137 substrate-Mg2+ binding site; other site 545693011138 catalytic residues [active] 545693011139 aspartate-rich region 1; other site 545693011140 active site lid residues [active] 545693011141 aspartate-rich region 2; other site 545693011142 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 545693011143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011144 S-adenosylmethionine binding site [chemical binding]; other site 545693011145 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 545693011146 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 545693011147 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 545693011148 homodecamer interface [polypeptide binding]; other site 545693011149 GTP cyclohydrolase I; Provisional; Region: PLN03044 545693011150 active site 545693011151 putative catalytic site residues [active] 545693011152 zinc binding site [ion binding]; other site 545693011153 GTP-CH-I/GFRP interaction surface; other site 545693011154 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 545693011155 IHF dimer interface [polypeptide binding]; other site 545693011156 IHF - DNA interface [nucleotide binding]; other site 545693011157 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 545693011158 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 545693011159 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 545693011160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011161 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 545693011162 GTP-binding protein Der; Reviewed; Region: PRK00093 545693011163 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 545693011164 G1 box; other site 545693011165 GTP/Mg2+ binding site [chemical binding]; other site 545693011166 Switch I region; other site 545693011167 G2 box; other site 545693011168 Switch II region; other site 545693011169 G3 box; other site 545693011170 G4 box; other site 545693011171 G5 box; other site 545693011172 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 545693011173 G1 box; other site 545693011174 GTP/Mg2+ binding site [chemical binding]; other site 545693011175 Switch I region; other site 545693011176 G2 box; other site 545693011177 G3 box; other site 545693011178 Switch II region; other site 545693011179 G4 box; other site 545693011180 G5 box; other site 545693011181 YpzI-like protein; Region: YpzI; pfam14140 545693011182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693011183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693011184 putative substrate translocation pore; other site 545693011185 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 545693011186 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 545693011187 homotetramer interface [polypeptide binding]; other site 545693011188 FMN binding site [chemical binding]; other site 545693011189 homodimer contacts [polypeptide binding]; other site 545693011190 putative active site [active] 545693011191 putative substrate binding site [chemical binding]; other site 545693011192 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 545693011193 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 545693011194 RNA binding site [nucleotide binding]; other site 545693011195 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 545693011196 RNA binding site [nucleotide binding]; other site 545693011197 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693011198 RNA binding site [nucleotide binding]; other site 545693011199 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 545693011200 RNA binding site [nucleotide binding]; other site 545693011201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693011202 putative acyl-acceptor binding pocket; other site 545693011203 cytidylate kinase; Provisional; Region: cmk; PRK00023 545693011204 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 545693011205 CMP-binding site; other site 545693011206 The sites determining sugar specificity; other site 545693011207 Flagellar protein YcgR; Region: YcgR_2; pfam12945 545693011208 PilZ domain; Region: PilZ; cl01260 545693011209 germination protein YpeB; Region: spore_YpeB; TIGR02889 545693011210 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693011211 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 545693011212 Protease prsW family; Region: PrsW-protease; cl15823 545693011213 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 545693011214 active site 545693011215 homotetramer interface [polypeptide binding]; other site 545693011216 homodimer interface [polypeptide binding]; other site 545693011217 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 545693011218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693011220 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693011221 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 545693011222 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 545693011223 NAD(P) binding site [chemical binding]; other site 545693011224 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 545693011225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693011226 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 545693011227 DNA binding residues [nucleotide binding] 545693011228 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 545693011229 B12 binding site [chemical binding]; other site 545693011230 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 545693011231 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 545693011232 putative active site [active] 545693011233 putative metal binding site [ion binding]; other site 545693011234 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 545693011235 CAAX protease self-immunity; Region: Abi; cl00558 545693011236 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693011237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693011238 ATP binding site [chemical binding]; other site 545693011239 putative Mg++ binding site [ion binding]; other site 545693011240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011241 nucleotide binding region [chemical binding]; other site 545693011242 ATP-binding site [chemical binding]; other site 545693011243 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 545693011244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 545693011245 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 545693011246 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 545693011247 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 545693011248 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 545693011249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011250 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 545693011251 putative L-serine binding site [chemical binding]; other site 545693011252 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693011253 autolysin; Reviewed; Region: PRK06347 545693011254 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693011255 putative peptidoglycan binding site; other site 545693011256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693011257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693011258 dimerization interface [polypeptide binding]; other site 545693011259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693011260 dimer interface [polypeptide binding]; other site 545693011261 phosphorylation site [posttranslational modification] 545693011262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693011263 ATP binding site [chemical binding]; other site 545693011264 Mg2+ binding site [ion binding]; other site 545693011265 G-X-G motif; other site 545693011266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693011267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693011268 active site 545693011269 phosphorylation site [posttranslational modification] 545693011270 intermolecular recognition site; other site 545693011271 dimerization interface [polypeptide binding]; other site 545693011272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693011273 DNA binding site [nucleotide binding] 545693011274 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 545693011275 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 545693011276 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 545693011277 ResB-like family; Region: ResB; pfam05140 545693011278 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 545693011279 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 545693011280 catalytic residues [active] 545693011281 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 545693011282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693011283 RNA binding surface [nucleotide binding]; other site 545693011284 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 545693011285 active site 545693011286 Nucleoside recognition; Region: Gate; cl00486 545693011287 Nucleoside recognition; Region: Gate; cl00486 545693011288 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 545693011289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693011290 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 545693011291 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 545693011292 ScpA/B protein; Region: ScpA_ScpB; cl00598 545693011293 Domain of unknown function (DUF309); Region: DUF309; cl00667 545693011294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693011295 Coenzyme A binding pocket [chemical binding]; other site 545693011296 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 545693011297 active site 545693011298 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 545693011299 diaminopimelate decarboxylase; Region: lysA; TIGR01048 545693011300 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 545693011301 active site 545693011302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 545693011303 substrate binding site [chemical binding]; other site 545693011304 catalytic residues [active] 545693011305 dimer interface [polypeptide binding]; other site 545693011306 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693011307 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 545693011308 SpoVA protein; Region: SpoVA; cl04298 545693011309 stage V sporulation protein AD; Validated; Region: PRK08304 545693011310 stage V sporulation protein AD; Provisional; Region: PRK12404 545693011311 SpoVA protein; Region: SpoVA; cl04298 545693011312 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 545693011313 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 545693011314 sporulation sigma factor SigF; Validated; Region: PRK05572 545693011315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011316 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693011317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011318 DNA binding residues [nucleotide binding] 545693011319 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 545693011320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693011321 ATP binding site [chemical binding]; other site 545693011322 Mg2+ binding site [ion binding]; other site 545693011323 G-X-G motif; other site 545693011324 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 545693011325 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 545693011326 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693011327 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 545693011328 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693011329 Sulfatase; Region: Sulfatase; cl10460 545693011330 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 545693011331 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 545693011332 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 545693011333 active site 545693011334 Int/Topo IB signature motif; other site 545693011335 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 545693011336 ferric uptake regulator; Provisional; Region: fur; PRK09462 545693011337 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693011338 metal binding site 2 [ion binding]; metal-binding site 545693011339 putative DNA binding helix; other site 545693011340 metal binding site 1 [ion binding]; metal-binding site 545693011341 dimer interface [polypeptide binding]; other site 545693011342 structural Zn2+ binding site [ion binding]; other site 545693011343 Integral membrane protein DUF95; Region: DUF95; cl00572 545693011344 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 545693011345 dimer interface [polypeptide binding]; other site 545693011346 ADP-ribose binding site [chemical binding]; other site 545693011347 active site 545693011348 nudix motif; other site 545693011349 metal binding site [ion binding]; metal-binding site 545693011350 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 545693011351 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 545693011352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693011353 active site 545693011354 catalytic tetrad [active] 545693011355 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693011356 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693011357 putative acyltransferase; Provisional; Region: PRK05790 545693011358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693011359 dimer interface [polypeptide binding]; other site 545693011360 active site 545693011361 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 545693011362 active site 545693011363 catalytic residues [active] 545693011364 metal binding site [ion binding]; metal-binding site 545693011365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693011366 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 545693011367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 545693011368 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 545693011369 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 545693011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011371 NAD(P) binding site [chemical binding]; other site 545693011372 active site 545693011373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693011374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011375 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 545693011376 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 545693011377 active site 545693011378 FMN binding site [chemical binding]; other site 545693011379 substrate binding site [chemical binding]; other site 545693011380 homotetramer interface [polypeptide binding]; other site 545693011381 catalytic residue [active] 545693011382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693011383 aminotransferase; Validated; Region: PRK07678 545693011384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693011385 inhibitor-cofactor binding pocket; inhibition site 545693011386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011387 catalytic residue [active] 545693011388 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 545693011389 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693011390 tetrameric interface [polypeptide binding]; other site 545693011391 NAD binding site [chemical binding]; other site 545693011392 catalytic residues [active] 545693011393 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 545693011394 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 545693011395 Helix-turn-helix domains; Region: HTH; cl00088 545693011396 phenylhydantoinase; Validated; Region: PRK08323 545693011397 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 545693011398 tetramer interface [polypeptide binding]; other site 545693011399 active site 545693011400 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 545693011401 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 545693011402 homodimer interface [polypeptide binding]; other site 545693011403 active site 545693011404 FMN binding site [chemical binding]; other site 545693011405 substrate binding site [chemical binding]; other site 545693011406 4Fe-4S binding domain; Region: Fer4; cl02805 545693011407 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 545693011408 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 545693011409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693011411 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 545693011412 peptidase T-like protein; Region: PepT-like; TIGR01883 545693011413 metal binding site [ion binding]; metal-binding site 545693011414 putative dimer interface [polypeptide binding]; other site 545693011415 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 545693011416 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693011417 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693011418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693011419 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 545693011420 dimer interface [polypeptide binding]; other site 545693011421 substrate binding site [chemical binding]; other site 545693011422 metal binding site [ion binding]; metal-binding site 545693011423 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 545693011424 Predicted membrane protein [Function unknown]; Region: COG4129 545693011425 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 545693011426 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 545693011427 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 545693011428 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 545693011429 Walker A/P-loop; other site 545693011430 ATP binding site [chemical binding]; other site 545693011431 Q-loop/lid; other site 545693011432 ABC transporter signature motif; other site 545693011433 Walker B; other site 545693011434 D-loop; other site 545693011435 H-loop/switch region; other site 545693011436 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 545693011437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693011438 dimer interface [polypeptide binding]; other site 545693011439 conserved gate region; other site 545693011440 putative PBP binding loops; other site 545693011441 ABC-ATPase subunit interface; other site 545693011442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693011443 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 545693011444 substrate binding pocket [chemical binding]; other site 545693011445 membrane-bound complex binding site; other site 545693011446 hinge residues; other site 545693011447 Disulphide isomerase; Region: Disulph_isomer; pfam06491 545693011448 membrane ATPase/protein kinase; Provisional; Region: PRK09435 545693011449 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 545693011450 Walker A; other site 545693011451 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 545693011452 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 545693011453 active site 545693011454 substrate binding site [chemical binding]; other site 545693011455 coenzyme B12 binding site [chemical binding]; other site 545693011456 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 545693011457 B12 binding site [chemical binding]; other site 545693011458 cobalt ligand [ion binding]; other site 545693011459 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 545693011460 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 545693011461 heterodimer interface [polypeptide binding]; other site 545693011462 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 545693011463 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 545693011464 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 545693011465 E3 interaction surface; other site 545693011466 lipoyl attachment site [posttranslational modification]; other site 545693011467 e3 binding domain; Region: E3_binding; pfam02817 545693011468 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 545693011469 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 545693011470 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 545693011471 alpha subunit interface [polypeptide binding]; other site 545693011472 TPP binding site [chemical binding]; other site 545693011473 heterodimer interface [polypeptide binding]; other site 545693011474 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693011475 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 545693011476 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 545693011477 tetramer interface [polypeptide binding]; other site 545693011478 TPP-binding site [chemical binding]; other site 545693011479 heterodimer interface [polypeptide binding]; other site 545693011480 phosphorylation loop region [posttranslational modification] 545693011481 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 545693011482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693011484 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 545693011485 Acetokinase family; Region: Acetate_kinase; cl01029 545693011486 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 545693011487 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 545693011488 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 545693011489 NAD binding site [chemical binding]; other site 545693011490 Phe binding site; other site 545693011491 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 545693011492 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 545693011493 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 545693011494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693011495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693011496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693011497 Walker A motif; other site 545693011498 ATP binding site [chemical binding]; other site 545693011499 Walker B motif; other site 545693011500 arginine finger; other site 545693011501 Helix-turn-helix domains; Region: HTH; cl00088 545693011502 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 545693011503 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 545693011504 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 545693011505 active site 545693011506 catalytic site [active] 545693011507 metal binding site [ion binding]; metal-binding site 545693011508 dimer interface [polypeptide binding]; other site 545693011509 YycC-like protein; Region: YycC; pfam14174 545693011510 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 545693011511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693011512 putative substrate translocation pore; other site 545693011513 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 545693011514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693011515 active site 545693011516 phosphorylation site [posttranslational modification] 545693011517 intermolecular recognition site; other site 545693011518 dimerization interface [polypeptide binding]; other site 545693011519 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 545693011520 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 545693011521 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 545693011522 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 545693011523 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 545693011524 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 545693011525 Walker A/P-loop; other site 545693011526 ATP binding site [chemical binding]; other site 545693011527 Q-loop/lid; other site 545693011528 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 545693011529 Q-loop/lid; other site 545693011530 ABC transporter signature motif; other site 545693011531 Walker B; other site 545693011532 D-loop; other site 545693011533 H-loop/switch region; other site 545693011534 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 545693011535 arginine repressor; Provisional; Region: PRK04280 545693011536 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 545693011537 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 545693011538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 545693011539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693011540 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 545693011541 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 545693011542 TPP-binding site; other site 545693011543 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 545693011544 PYR/PP interface [polypeptide binding]; other site 545693011545 dimer interface [polypeptide binding]; other site 545693011546 TPP binding site [chemical binding]; other site 545693011547 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 545693011548 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 545693011549 substrate binding pocket [chemical binding]; other site 545693011550 chain length determination region; other site 545693011551 substrate-Mg2+ binding site; other site 545693011552 catalytic residues [active] 545693011553 aspartate-rich region 1; other site 545693011554 active site lid residues [active] 545693011555 aspartate-rich region 2; other site 545693011556 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 545693011557 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 545693011558 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 545693011559 generic binding surface II; other site 545693011560 generic binding surface I; other site 545693011561 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 545693011562 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 545693011563 putative RNA binding site [nucleotide binding]; other site 545693011564 Asp23 family; Region: Asp23; cl00574 545693011565 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 545693011566 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 545693011567 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693011568 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 545693011569 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 545693011570 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 545693011571 carboxyltransferase (CT) interaction site; other site 545693011572 biotinylation site [posttranslational modification]; other site 545693011573 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 545693011574 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 545693011575 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 545693011576 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 545693011577 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 545693011578 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 545693011579 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 545693011580 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 545693011581 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 545693011582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693011583 Walker A motif; other site 545693011584 ATP binding site [chemical binding]; other site 545693011585 Walker B motif; other site 545693011586 arginine finger; other site 545693011587 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 545693011588 elongation factor P; Validated; Region: PRK00529 545693011589 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 545693011590 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 545693011591 RNA binding site [nucleotide binding]; other site 545693011592 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 545693011593 RNA binding site [nucleotide binding]; other site 545693011594 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 545693011595 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 545693011596 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 545693011597 active site 545693011598 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 545693011599 trimer interface [polypeptide binding]; other site 545693011600 active site 545693011601 dimer interface [polypeptide binding]; other site 545693011602 Conserved membrane protein YqhR; Region: YqhR; pfam11085 545693011603 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 545693011604 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 545693011605 active site 545693011606 nucleophile elbow; other site 545693011607 manganese transport transcriptional regulator; Provisional; Region: PRK03902 545693011608 Helix-turn-helix domains; Region: HTH; cl00088 545693011609 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 545693011610 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, degenerate 545693011611 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 545693011612 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 545693011613 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 545693011614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693011615 active site residue [active] 545693011616 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 545693011617 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 545693011618 tetramer interface [polypeptide binding]; other site 545693011619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011620 catalytic residue [active] 545693011621 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 545693011622 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 545693011623 tetramer interface [polypeptide binding]; other site 545693011624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011625 catalytic residue [active] 545693011626 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 545693011627 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 545693011628 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693011629 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 545693011630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693011631 ATP binding site [chemical binding]; other site 545693011632 putative Mg++ binding site [ion binding]; other site 545693011633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011634 nucleotide binding region [chemical binding]; other site 545693011635 ATP-binding site [chemical binding]; other site 545693011636 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 545693011637 YqzE-like protein; Region: YqzE; pfam14038 545693011638 ComG operon protein 7; Region: ComGG; pfam14173 545693011639 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 545693011640 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 545693011641 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 545693011642 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 545693011643 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 545693011644 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 545693011645 type IV pilin biogenesis protein; Provisional; Region: PRK10573 545693011646 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 545693011647 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 545693011648 Type II/IV secretion system protein; Region: T2SE; pfam00437 545693011649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693011650 Walker A motif; other site 545693011651 ATP binding site [chemical binding]; other site 545693011652 Walker B motif; other site 545693011653 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 545693011654 ArsC family; Region: ArsC; pfam03960 545693011655 putative catalytic residues [active] 545693011656 thiol/disulfide switch; other site 545693011657 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 545693011658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693011659 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 545693011660 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 545693011661 putative active site [active] 545693011662 Zn binding site [ion binding]; other site 545693011663 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 545693011664 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 545693011665 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 545693011666 Rhomboid family; Region: Rhomboid; cl11446 545693011667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011668 binding surface 545693011669 TPR motif; other site 545693011670 TPR repeat; Region: TPR_11; pfam13414 545693011671 Integral membrane protein DUF92; Region: DUF92; cl00793 545693011672 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 545693011673 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 545693011674 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 545693011675 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 545693011676 active site 545693011677 Substrate binding site; other site 545693011678 Mg++ binding site; other site 545693011679 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 545693011680 putative trimer interface [polypeptide binding]; other site 545693011681 putative CoA binding site [chemical binding]; other site 545693011682 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 545693011683 active site 545693011684 substrate binding site [chemical binding]; other site 545693011685 metal binding site [ion binding]; metal-binding site 545693011686 Uncharacterized conserved protein [Function unknown]; Region: COG1543 545693011687 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693011688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693011689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 545693011690 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 545693011691 PhoU domain; Region: PhoU; pfam01895 545693011692 PhoU domain; Region: PhoU; pfam01895 545693011693 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 545693011694 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 545693011695 Walker A/P-loop; other site 545693011696 ATP binding site [chemical binding]; other site 545693011697 Q-loop/lid; other site 545693011698 ABC transporter signature motif; other site 545693011699 Walker B; other site 545693011700 D-loop; other site 545693011701 H-loop/switch region; other site 545693011702 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693011703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693011704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693011705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693011706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693011707 putative substrate translocation pore; other site 545693011708 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 545693011709 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 545693011710 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 545693011711 Protein of unknown function (DUF456); Region: DUF456; cl01069 545693011712 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 545693011713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693011714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693011715 putative substrate translocation pore; other site 545693011716 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 545693011717 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 545693011718 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 545693011719 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693011720 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 545693011721 metal binding site 2 [ion binding]; metal-binding site 545693011722 putative DNA binding helix; other site 545693011723 metal binding site 1 [ion binding]; metal-binding site 545693011724 dimer interface [polypeptide binding]; other site 545693011725 structural Zn2+ binding site [ion binding]; other site 545693011726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693011727 ABC-ATPase subunit interface; other site 545693011728 dimer interface [polypeptide binding]; other site 545693011729 putative PBP binding regions; other site 545693011730 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 545693011731 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 545693011732 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 545693011733 endonuclease IV; Provisional; Region: PRK01060 545693011734 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 545693011735 AP (apurinic/apyrimidinic) site pocket; other site 545693011736 DNA interaction; other site 545693011737 Metal-binding active site; metal-binding site 545693011738 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 545693011739 DEAD-like helicases superfamily; Region: DEXDc; smart00487 545693011740 ATP binding site [chemical binding]; other site 545693011741 Mg++ binding site [ion binding]; other site 545693011742 motif III; other site 545693011743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693011744 nucleotide binding region [chemical binding]; other site 545693011745 ATP-binding site [chemical binding]; other site 545693011746 YqfQ-like protein; Region: YqfQ; pfam14181 545693011747 LytB protein; Region: LYTB; cl00507 545693011748 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 545693011749 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 545693011750 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 545693011751 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 545693011752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011753 Cytochrome c; Region: Cytochrom_C; cl11414 545693011754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693011755 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693011756 active site 545693011757 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 545693011758 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 545693011759 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 545693011760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011761 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 545693011762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011763 DNA binding residues [nucleotide binding] 545693011764 DNA primase; Validated; Region: dnaG; PRK05667 545693011765 CHC2 zinc finger; Region: zf-CHC2; cl15369 545693011766 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 545693011767 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 545693011768 active site 545693011769 metal binding site [ion binding]; metal-binding site 545693011770 interdomain interaction site; other site 545693011771 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 545693011772 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 545693011773 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 545693011774 Helix-turn-helix domains; Region: HTH; cl00088 545693011775 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 545693011776 FOG: CBS domain [General function prediction only]; Region: COG0517 545693011777 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 545693011778 Recombination protein O N terminal; Region: RecO_N; cl15812 545693011779 Recombination protein O C terminal; Region: RecO_C; pfam02565 545693011780 GTPase Era; Reviewed; Region: era; PRK00089 545693011781 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 545693011782 G1 box; other site 545693011783 GTP/Mg2+ binding site [chemical binding]; other site 545693011784 Switch I region; other site 545693011785 G2 box; other site 545693011786 Switch II region; other site 545693011787 G3 box; other site 545693011788 G4 box; other site 545693011789 G5 box; other site 545693011790 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 545693011791 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 545693011792 active site 545693011793 catalytic motif [active] 545693011794 Zn binding site [ion binding]; other site 545693011795 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 545693011796 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 545693011797 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 545693011798 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 545693011799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693011800 Zn2+ binding site [ion binding]; other site 545693011801 Mg2+ binding site [ion binding]; other site 545693011802 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 545693011803 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 545693011804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693011805 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 545693011806 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 545693011807 YabP family; Region: YabP; cl06766 545693011808 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 545693011809 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 545693011810 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 545693011811 dimer interface [polypeptide binding]; other site 545693011812 active site residues [active] 545693011813 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 545693011814 GatB domain; Region: GatB_Yqey; cl11497 545693011815 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 545693011816 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 545693011817 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 545693011818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693011819 FeS/SAM binding site; other site 545693011820 TRAM domain; Region: TRAM; cl01282 545693011821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 545693011822 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 545693011823 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 545693011824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011825 S-adenosylmethionine binding site [chemical binding]; other site 545693011826 chaperone protein DnaJ; Provisional; Region: PRK14280 545693011827 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 545693011828 HSP70 interaction site [polypeptide binding]; other site 545693011829 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 545693011830 substrate binding site [polypeptide binding]; other site 545693011831 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 545693011832 Zn binding sites [ion binding]; other site 545693011833 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 545693011834 dimer interface [polypeptide binding]; other site 545693011835 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 545693011836 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 545693011837 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 545693011838 dimer interface [polypeptide binding]; other site 545693011839 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 545693011840 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 545693011841 Helix-turn-helix domains; Region: HTH; cl00088 545693011842 HrcA protein C terminal domain; Region: HrcA; pfam01628 545693011843 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 545693011844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693011845 FeS/SAM binding site; other site 545693011846 HemN C-terminal domain; Region: HemN_C; pfam06969 545693011847 GTP-binding protein LepA; Provisional; Region: PRK05433 545693011848 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 545693011849 G1 box; other site 545693011850 putative GEF interaction site [polypeptide binding]; other site 545693011851 GTP/Mg2+ binding site [chemical binding]; other site 545693011852 Switch I region; other site 545693011853 G2 box; other site 545693011854 G3 box; other site 545693011855 Switch II region; other site 545693011856 G4 box; other site 545693011857 G5 box; other site 545693011858 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 545693011859 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 545693011860 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 545693011861 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 545693011862 Germination protease; Region: Peptidase_A25; cl04057 545693011863 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 545693011864 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 545693011865 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 545693011866 YqzM-like protein; Region: YqzM; pfam14141 545693011867 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 545693011868 Competence protein; Region: Competence; cl00471 545693011869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693011870 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 545693011871 catalytic motif [active] 545693011872 Zn binding site [ion binding]; other site 545693011873 SLBB domain; Region: SLBB; pfam10531 545693011874 comEA protein; Region: comE; TIGR01259 545693011875 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 545693011876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011877 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 545693011878 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 545693011879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693011880 S-adenosylmethionine binding site [chemical binding]; other site 545693011881 Oligomerisation domain; Region: Oligomerisation; cl00519 545693011882 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 545693011883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 545693011884 Zn2+ binding site [ion binding]; other site 545693011885 Mg2+ binding site [ion binding]; other site 545693011886 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 545693011887 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 545693011888 active site 545693011889 (T/H)XGH motif; other site 545693011890 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 545693011891 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 545693011892 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 545693011893 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 545693011894 shikimate binding site; other site 545693011895 NAD(P) binding site [chemical binding]; other site 545693011896 GTPase YqeH; Provisional; Region: PRK13796 545693011897 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 545693011898 GTP/Mg2+ binding site [chemical binding]; other site 545693011899 G4 box; other site 545693011900 G5 box; other site 545693011901 G1 box; other site 545693011902 Switch I region; other site 545693011903 G2 box; other site 545693011904 G3 box; other site 545693011905 Switch II region; other site 545693011906 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 545693011907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693011908 active site 545693011909 motif I; other site 545693011910 motif II; other site 545693011911 Sporulation inhibitor A; Region: Sda; pfam08970 545693011912 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 545693011913 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693011914 sporulation sigma factor SigK; Reviewed; Region: PRK05803 545693011915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693011916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693011917 DNA binding residues [nucleotide binding] 545693011918 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 545693011919 YrhC-like protein; Region: YrhC; pfam14143 545693011920 cystathionine beta-lyase; Provisional; Region: PRK07671 545693011921 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 545693011922 homodimer interface [polypeptide binding]; other site 545693011923 substrate-cofactor binding pocket; other site 545693011924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011925 catalytic residue [active] 545693011926 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 545693011927 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693011928 dimer interface [polypeptide binding]; other site 545693011929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693011930 catalytic residue [active] 545693011931 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 545693011932 5'-methylthioadenosine nucleosidase; Region: PLN02584 545693011933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011934 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 545693011935 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 545693011936 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 545693011937 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693011938 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693011939 Isochorismatase family; Region: Isochorismatase; pfam00857 545693011940 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 545693011941 catalytic triad [active] 545693011942 conserved cis-peptide bond; other site 545693011943 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 545693011944 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 545693011945 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 545693011946 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 545693011947 ATP-binding site [chemical binding]; other site 545693011948 Sugar specificity; other site 545693011949 Pyrimidine base specificity; other site 545693011950 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 545693011951 Peptidase family U32; Region: Peptidase_U32; cl03113 545693011952 Peptidase family U32; Region: Peptidase_U32; cl03113 545693011953 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 545693011954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693011955 YceG-like family; Region: YceG; pfam02618 545693011956 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 545693011957 dimerization interface [polypeptide binding]; other site 545693011958 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 545693011959 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 545693011960 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 545693011961 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 545693011962 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 545693011963 motif 1; other site 545693011964 active site 545693011965 motif 2; other site 545693011966 motif 3; other site 545693011967 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 545693011968 DHHA1 domain; Region: DHHA1; pfam02272 545693011969 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 545693011970 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 545693011971 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 545693011972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693011973 Family description; Region: UvrD_C_2; cl15862 545693011974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011975 binding surface 545693011976 TPR motif; other site 545693011977 TPR repeat; Region: TPR_11; pfam13414 545693011978 TPR repeat; Region: TPR_11; pfam13414 545693011979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693011980 binding surface 545693011981 TPR motif; other site 545693011982 TPR repeat; Region: TPR_11; pfam13414 545693011983 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 545693011984 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 545693011985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693011986 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 545693011987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693011988 catalytic residue [active] 545693011989 Predicted transcriptional regulator [Transcription]; Region: COG1959 545693011990 Helix-turn-helix domains; Region: HTH; cl00088 545693011991 recombination factor protein RarA; Reviewed; Region: PRK13342 545693011992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693011993 Walker A motif; other site 545693011994 ATP binding site [chemical binding]; other site 545693011995 Walker B motif; other site 545693011996 arginine finger; other site 545693011997 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 545693011998 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 545693011999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012000 dimer interface [polypeptide binding]; other site 545693012001 conserved gate region; other site 545693012002 putative PBP binding loops; other site 545693012003 ABC-ATPase subunit interface; other site 545693012004 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 545693012005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012006 dimer interface [polypeptide binding]; other site 545693012007 conserved gate region; other site 545693012008 putative PBP binding loops; other site 545693012009 ABC-ATPase subunit interface; other site 545693012010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693012011 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 545693012012 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 545693012013 putative ATP binding site [chemical binding]; other site 545693012014 putative substrate interface [chemical binding]; other site 545693012015 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 545693012016 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 545693012017 dimer interface [polypeptide binding]; other site 545693012018 anticodon binding site; other site 545693012019 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 545693012020 homodimer interface [polypeptide binding]; other site 545693012021 motif 1; other site 545693012022 active site 545693012023 motif 2; other site 545693012024 GAD domain; Region: GAD; pfam02938 545693012025 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 545693012026 motif 3; other site 545693012027 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 545693012028 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 545693012029 dimer interface [polypeptide binding]; other site 545693012030 motif 1; other site 545693012031 active site 545693012032 motif 2; other site 545693012033 motif 3; other site 545693012034 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 545693012035 anticodon binding site; other site 545693012036 Bacterial SH3 domain; Region: SH3_3; cl02551 545693012037 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 545693012038 active site 545693012039 metal binding site [ion binding]; metal-binding site 545693012040 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 545693012041 putative active site [active] 545693012042 dimerization interface [polypeptide binding]; other site 545693012043 putative tRNAtyr binding site [nucleotide binding]; other site 545693012044 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 545693012045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693012046 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 545693012047 synthetase active site [active] 545693012048 NTP binding site [chemical binding]; other site 545693012049 metal binding site [ion binding]; metal-binding site 545693012050 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 545693012051 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 545693012052 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 545693012053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693012054 active site 545693012055 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 545693012056 DHH family; Region: DHH; pfam01368 545693012057 DHHA1 domain; Region: DHHA1; pfam02272 545693012058 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 545693012059 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 545693012060 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 545693012061 Protein export membrane protein; Region: SecD_SecF; cl14618 545693012062 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 545693012063 Protein export membrane protein; Region: SecD_SecF; cl14618 545693012064 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 545693012065 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693012066 MatE; Region: MatE; cl10513 545693012067 MatE; Region: MatE; cl10513 545693012068 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693012069 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 545693012070 Preprotein translocase subunit; Region: YajC; cl00806 545693012071 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 545693012072 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 545693012073 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 545693012074 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 545693012075 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 545693012076 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 545693012077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012078 Walker A motif; other site 545693012079 ATP binding site [chemical binding]; other site 545693012080 Walker B motif; other site 545693012081 arginine finger; other site 545693012082 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 545693012083 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 545693012084 RuvA N terminal domain; Region: RuvA_N; pfam01330 545693012085 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 545693012086 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 545693012087 BofC C-terminal domain; Region: BofC_C; pfam08955 545693012088 Heat induced stress protein YflT; Region: YflT; pfam11181 545693012089 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 545693012090 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693012091 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693012092 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693012093 putative peptidoglycan binding site; other site 545693012094 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 545693012095 Quinolinate synthetase A protein; Region: NadA; cl00420 545693012096 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 545693012097 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 545693012098 dimerization interface [polypeptide binding]; other site 545693012099 active site 545693012100 L-aspartate oxidase; Provisional; Region: PRK08071 545693012101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012102 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693012103 putative cysteine desulfurase, frameshift 545693012104 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 545693012105 Helix-turn-helix domains; Region: HTH; cl00088 545693012106 3H domain; Region: 3H; pfam02829 545693012107 prephenate dehydratase; Provisional; Region: PRK11898 545693012108 Prephenate dehydratase; Region: PDT; pfam00800 545693012109 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 545693012110 putative L-Phe binding site [chemical binding]; other site 545693012111 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 545693012112 hypothetical protein; Provisional; Region: PRK04435 545693012113 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 545693012114 GTPase CgtA; Reviewed; Region: obgE; PRK12297 545693012115 GTP1/OBG; Region: GTP1_OBG; pfam01018 545693012116 Obg GTPase; Region: Obg; cd01898 545693012117 G1 box; other site 545693012118 GTP/Mg2+ binding site [chemical binding]; other site 545693012119 Switch I region; other site 545693012120 G2 box; other site 545693012121 G3 box; other site 545693012122 Switch II region; other site 545693012123 G4 box; other site 545693012124 G5 box; other site 545693012125 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 545693012126 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 545693012127 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 545693012128 Protein of unknown function (DUF464); Region: DUF464; cl01080 545693012129 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 545693012130 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 545693012131 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 545693012132 homodimer interface [polypeptide binding]; other site 545693012133 oligonucleotide binding site [chemical binding]; other site 545693012134 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 545693012135 active site 545693012136 putative substrate binding region [chemical binding]; other site 545693012137 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693012138 septum site-determining protein MinD; Region: minD_bact; TIGR01968 545693012139 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 545693012140 Switch I; other site 545693012141 Switch II; other site 545693012142 septum formation inhibitor; Reviewed; Region: minC; PRK00513 545693012143 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 545693012144 rod shape-determining protein MreD; Region: MreD; cl01087 545693012145 rod shape-determining protein MreC; Provisional; Region: PRK13922 545693012146 rod shape-determining protein MreC; Region: MreC; pfam04085 545693012147 rod shape-determining protein MreB; Provisional; Region: PRK13927 545693012148 Cell division protein FtsA; Region: FtsA; cl11496 545693012149 hypothetical protein; Reviewed; Region: PRK00024 545693012150 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 545693012151 MPN+ (JAMM) motif; other site 545693012152 Zinc-binding site [ion binding]; other site 545693012153 Maf-like protein; Region: Maf; pfam02545 545693012154 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 545693012155 active site 545693012156 dimer interface [polypeptide binding]; other site 545693012157 Sporulation related domain; Region: SPOR; cl10051 545693012158 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 545693012159 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 545693012160 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 545693012161 Protein of unknown function (DUF420); Region: DUF420; cl00989 545693012162 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 545693012163 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693012164 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693012165 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 545693012166 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 545693012167 active site 545693012168 HIGH motif; other site 545693012169 nucleotide binding site [chemical binding]; other site 545693012170 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693012171 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 545693012172 active site 545693012173 KMSKS motif; other site 545693012174 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 545693012175 tRNA binding surface [nucleotide binding]; other site 545693012176 anticodon binding site; other site 545693012177 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 545693012178 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693012179 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 545693012180 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693012181 putative peptidoglycan binding site; other site 545693012182 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 545693012183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 545693012184 inhibitor-cofactor binding pocket; inhibition site 545693012185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012186 catalytic residue [active] 545693012187 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 545693012188 dimer interface [polypeptide binding]; other site 545693012189 active site 545693012190 Schiff base residues; other site 545693012191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 545693012192 active site 545693012193 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 545693012194 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 545693012195 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 545693012196 domain interfaces; other site 545693012197 active site 545693012198 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 545693012199 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 545693012200 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 545693012201 tRNA; other site 545693012202 putative tRNA binding site [nucleotide binding]; other site 545693012203 putative NADP binding site [chemical binding]; other site 545693012204 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 545693012205 Predicted GTPase [General function prediction only]; Region: COG0218 545693012206 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 545693012207 G1 box; other site 545693012208 GTP/Mg2+ binding site [chemical binding]; other site 545693012209 Switch I region; other site 545693012210 G2 box; other site 545693012211 G3 box; other site 545693012212 Switch II region; other site 545693012213 G4 box; other site 545693012214 G5 box; other site 545693012215 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 545693012216 Found in ATP-dependent protease La (LON); Region: LON; smart00464 545693012217 Found in ATP-dependent protease La (LON); Region: LON; smart00464 545693012218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012219 Walker A motif; other site 545693012220 ATP binding site [chemical binding]; other site 545693012221 Walker B motif; other site 545693012222 arginine finger; other site 545693012223 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 545693012224 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 545693012225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012226 Walker A motif; other site 545693012227 ATP binding site [chemical binding]; other site 545693012228 Walker B motif; other site 545693012229 arginine finger; other site 545693012230 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 545693012231 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 545693012232 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 545693012233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012234 Walker A motif; other site 545693012235 ATP binding site [chemical binding]; other site 545693012236 Walker B motif; other site 545693012237 arginine finger; other site 545693012238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 545693012239 trigger factor; Provisional; Region: tig; PRK01490 545693012240 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 545693012241 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 545693012242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693012243 binding surface 545693012244 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693012245 TPR motif; other site 545693012246 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 545693012247 substrate binding site [chemical binding]; other site 545693012248 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 545693012249 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 545693012250 substrate binding site [chemical binding]; other site 545693012251 ligand binding site [chemical binding]; other site 545693012252 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 545693012253 tartrate dehydrogenase; Provisional; Region: PRK08194 545693012254 2-isopropylmalate synthase; Validated; Region: PRK00915 545693012255 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 545693012256 active site 545693012257 catalytic residues [active] 545693012258 metal binding site [ion binding]; metal-binding site 545693012259 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 545693012260 ketol-acid reductoisomerase; Provisional; Region: PRK05479 545693012261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012262 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 545693012263 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 545693012264 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 545693012265 putative valine binding site [chemical binding]; other site 545693012266 dimer interface [polypeptide binding]; other site 545693012267 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 545693012268 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 545693012269 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 545693012270 PYR/PP interface [polypeptide binding]; other site 545693012271 dimer interface [polypeptide binding]; other site 545693012272 TPP binding site [chemical binding]; other site 545693012273 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 545693012274 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 545693012275 TPP-binding site [chemical binding]; other site 545693012276 dimer interface [polypeptide binding]; other site 545693012277 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 545693012278 active site 545693012279 metal binding site [ion binding]; metal-binding site 545693012280 homotetramer interface [polypeptide binding]; other site 545693012281 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 545693012282 active site 545693012283 dimerization interface [polypeptide binding]; other site 545693012284 ribonuclease PH; Reviewed; Region: rph; PRK00173 545693012285 Ribonuclease PH; Region: RNase_PH_bact; cd11362 545693012286 hexamer interface [polypeptide binding]; other site 545693012287 active site 545693012288 Spore germination protein [General function prediction only]; Region: COG5401 545693012289 Sporulation and spore germination; Region: Germane; cl11253 545693012290 Sporulation and spore germination; Region: Germane; cl11253 545693012291 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 545693012292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693012293 Helix-turn-helix domains; Region: HTH; cl00088 545693012294 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 545693012295 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 545693012296 Phosphate transporter family; Region: PHO4; cl00396 545693012297 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 545693012298 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 545693012299 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 545693012300 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 545693012301 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693012302 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 545693012303 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 545693012304 active site 545693012305 dimer interface [polypeptide binding]; other site 545693012306 non-prolyl cis peptide bond; other site 545693012307 insertion regions; other site 545693012308 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693012309 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693012310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693012311 dimer interface [polypeptide binding]; other site 545693012312 conserved gate region; other site 545693012313 putative PBP binding loops; other site 545693012314 ABC-ATPase subunit interface; other site 545693012315 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 545693012316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 545693012317 substrate binding pocket [chemical binding]; other site 545693012318 membrane-bound complex binding site; other site 545693012319 hinge residues; other site 545693012320 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693012321 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 545693012322 Walker A/P-loop; other site 545693012323 ATP binding site [chemical binding]; other site 545693012324 Q-loop/lid; other site 545693012325 ABC transporter signature motif; other site 545693012326 Walker B; other site 545693012327 D-loop; other site 545693012328 H-loop/switch region; other site 545693012329 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693012330 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 545693012331 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 545693012332 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 545693012333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693012334 DNA binding residues [nucleotide binding] 545693012335 dimerization interface [polypeptide binding]; other site 545693012336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693012337 active site 545693012338 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 545693012339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 545693012340 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 545693012341 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 545693012342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 545693012344 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 545693012345 putative Iron-sulfur protein interface [polypeptide binding]; other site 545693012346 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 545693012347 proximal heme binding site [chemical binding]; other site 545693012348 distal heme binding site [chemical binding]; other site 545693012349 putative dimer interface [polypeptide binding]; other site 545693012350 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 545693012351 aspartate kinase; Reviewed; Region: PRK06635 545693012352 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 545693012353 putative nucleotide binding site [chemical binding]; other site 545693012354 putative catalytic residues [active] 545693012355 putative Mg ion binding site [ion binding]; other site 545693012356 putative aspartate binding site [chemical binding]; other site 545693012357 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 545693012358 putative allosteric regulatory site; other site 545693012359 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 545693012360 putative allosteric regulatory residue; other site 545693012361 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 545693012362 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 545693012363 GIY-YIG motif/motif A; other site 545693012364 active site 545693012365 catalytic site [active] 545693012366 putative DNA binding site [nucleotide binding]; other site 545693012367 metal binding site [ion binding]; metal-binding site 545693012368 UvrB/uvrC motif; Region: UVR; pfam02151 545693012369 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 545693012370 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693012371 catalytic residues [active] 545693012372 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 545693012373 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 545693012374 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 545693012375 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 545693012376 Ligand binding site [chemical binding]; other site 545693012377 Electron transfer flavoprotein domain; Region: ETF; pfam01012 545693012378 enoyl-CoA hydratase; Provisional; Region: PRK07658 545693012379 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693012380 substrate binding site [chemical binding]; other site 545693012381 oxyanion hole (OAH) forming residues; other site 545693012382 trimer interface [polypeptide binding]; other site 545693012383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 545693012384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693012385 Helix-turn-helix domains; Region: HTH; cl00088 545693012386 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 545693012387 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 545693012388 AMP-binding enzyme; Region: AMP-binding; cl15778 545693012389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693012390 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 545693012391 substrate binding site [chemical binding]; other site 545693012392 THF binding site; other site 545693012393 zinc-binding site [ion binding]; other site 545693012394 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693012395 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 545693012396 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 545693012397 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 545693012398 Walker A/P-loop; other site 545693012399 ATP binding site [chemical binding]; other site 545693012400 Q-loop/lid; other site 545693012401 ABC transporter signature motif; other site 545693012402 Walker B; other site 545693012403 D-loop; other site 545693012404 H-loop/switch region; other site 545693012405 Smr domain; Region: Smr; cl02619 545693012406 hypothetical protein; Provisional; Region: PRK08609 545693012407 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 545693012408 active site 545693012409 primer binding site [nucleotide binding]; other site 545693012410 NTP binding site [chemical binding]; other site 545693012411 metal binding triad [ion binding]; metal-binding site 545693012412 Colicin V production protein; Region: Colicin_V; cl00567 545693012413 Cell division protein ZapA; Region: ZapA; cl01146 545693012414 ribonuclease HIII; Provisional; Region: PRK00996 545693012415 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 545693012416 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 545693012417 RNA/DNA hybrid binding site [nucleotide binding]; other site 545693012418 active site 545693012419 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 545693012420 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 545693012421 putative tRNA-binding site [nucleotide binding]; other site 545693012422 B3/4 domain; Region: B3_4; cl11458 545693012423 tRNA synthetase B5 domain; Region: B5; cl08394 545693012424 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 545693012425 dimer interface [polypeptide binding]; other site 545693012426 motif 1; other site 545693012427 motif 3; other site 545693012428 motif 2; other site 545693012429 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 545693012430 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 545693012431 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 545693012432 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 545693012433 dimer interface [polypeptide binding]; other site 545693012434 motif 1; other site 545693012435 active site 545693012436 motif 2; other site 545693012437 motif 3; other site 545693012438 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 545693012439 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 545693012440 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 545693012441 Small, acid-soluble spore protein I; Region: SSPI; cl07940 545693012442 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 545693012443 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 545693012444 oligomer interface [polypeptide binding]; other site 545693012445 active site 545693012446 metal binding site [ion binding]; metal-binding site 545693012447 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 545693012448 dUTPase; Region: dUTPase_2; pfam08761 545693012449 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 545693012450 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 545693012451 23S rRNA binding site [nucleotide binding]; other site 545693012452 L21 binding site [polypeptide binding]; other site 545693012453 L13 binding site [polypeptide binding]; other site 545693012454 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 545693012455 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 545693012456 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 545693012457 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 545693012458 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 545693012459 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 545693012460 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 545693012461 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 545693012462 active site 545693012463 dimer interface [polypeptide binding]; other site 545693012464 motif 1; other site 545693012465 motif 2; other site 545693012466 motif 3; other site 545693012467 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 545693012468 anticodon binding site; other site 545693012469 YtxC-like family; Region: YtxC; cl08500 545693012470 primosomal protein DnaI; Reviewed; Region: PRK08939 545693012471 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 545693012472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693012473 Walker A motif; other site 545693012474 ATP binding site [chemical binding]; other site 545693012475 Walker B motif; other site 545693012476 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 545693012477 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 545693012478 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 545693012479 ATP cone domain; Region: ATP-cone; pfam03477 545693012480 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 545693012481 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 545693012482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 545693012484 dephospho-CoA kinase; Region: TIGR00152 545693012485 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 545693012486 CoA-binding site [chemical binding]; other site 545693012487 ATP-binding [chemical binding]; other site 545693012488 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 545693012489 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 545693012490 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 545693012491 DNA binding site [nucleotide binding] 545693012492 catalytic residue [active] 545693012493 H2TH interface [polypeptide binding]; other site 545693012494 putative catalytic residues [active] 545693012495 turnover-facilitating residue; other site 545693012496 intercalation triad [nucleotide binding]; other site 545693012497 8OG recognition residue [nucleotide binding]; other site 545693012498 putative reading head residues; other site 545693012499 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 545693012500 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 545693012501 DNA polymerase I; Provisional; Region: PRK05755 545693012502 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 545693012503 active site 545693012504 metal binding site 1 [ion binding]; metal-binding site 545693012505 putative 5' ssDNA interaction site; other site 545693012506 metal binding site 3; metal-binding site 545693012507 metal binding site 2 [ion binding]; metal-binding site 545693012508 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 545693012509 putative DNA binding site [nucleotide binding]; other site 545693012510 putative metal binding site [ion binding]; other site 545693012511 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 545693012512 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 545693012513 active site 545693012514 DNA binding site [nucleotide binding] 545693012515 catalytic site [active] 545693012516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693012517 dimerization interface [polypeptide binding]; other site 545693012518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 545693012519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693012520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693012521 dimer interface [polypeptide binding]; other site 545693012522 phosphorylation site [posttranslational modification] 545693012523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693012524 ATP binding site [chemical binding]; other site 545693012525 Mg2+ binding site [ion binding]; other site 545693012526 G-X-G motif; other site 545693012527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693012528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693012529 active site 545693012530 phosphorylation site [posttranslational modification] 545693012531 intermolecular recognition site; other site 545693012532 dimerization interface [polypeptide binding]; other site 545693012533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693012534 DNA binding site [nucleotide binding] 545693012535 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 545693012536 dimer interaction site [polypeptide binding]; other site 545693012537 substrate-binding tunnel; other site 545693012538 active site 545693012539 catalytic site [active] 545693012540 substrate binding site [chemical binding]; other site 545693012541 malate dehydrogenase; Reviewed; Region: PRK06223 545693012542 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 545693012543 NAD(P) binding site [chemical binding]; other site 545693012544 dimer interface [polypeptide binding]; other site 545693012545 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693012546 substrate binding site [chemical binding]; other site 545693012547 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 545693012548 isocitrate dehydrogenase; Validated; Region: PRK06451 545693012549 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 545693012550 dimer interface [polypeptide binding]; other site 545693012551 Citrate synthase; Region: Citrate_synt; pfam00285 545693012552 active site 545693012553 citrylCoA binding site [chemical binding]; other site 545693012554 oxalacetate/citrate binding site [chemical binding]; other site 545693012555 coenzyme A binding site [chemical binding]; other site 545693012556 catalytic triad [active] 545693012557 Protein of unknown function (DUF441); Region: DUF441; cl01041 545693012558 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 545693012559 Domain of unknown function DUF20; Region: UPF0118; pfam01594 545693012560 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 545693012561 pyruvate kinase; Provisional; Region: PRK06354 545693012562 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 545693012563 domain interfaces; other site 545693012564 active site 545693012565 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 545693012566 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693012567 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 545693012568 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 545693012569 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 545693012570 Transcriptional regulators [Transcription]; Region: FadR; COG2186 545693012571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693012572 DNA-binding site [nucleotide binding]; DNA binding site 545693012573 Malic enzyme, N-terminal domain; Region: malic; pfam00390 545693012574 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 545693012575 putative NAD(P) binding site [chemical binding]; other site 545693012576 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 545693012577 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 545693012578 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 545693012579 generic binding surface I; other site 545693012580 generic binding surface II; other site 545693012581 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 545693012582 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 545693012583 DHH family; Region: DHH; pfam01368 545693012584 DHHA1 domain; Region: DHHA1; pfam02272 545693012585 YtpI-like protein; Region: YtpI; pfam14007 545693012586 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 545693012587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 545693012588 DNA-binding site [nucleotide binding]; DNA binding site 545693012589 DRTGG domain; Region: DRTGG; cl12147 545693012590 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 545693012591 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 545693012592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693012593 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 545693012594 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 545693012595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012596 argininosuccinate lyase; Provisional; Region: PRK00855 545693012597 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 545693012598 active sites [active] 545693012599 tetramer interface [polypeptide binding]; other site 545693012600 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 545693012601 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 545693012602 ANP binding site [chemical binding]; other site 545693012603 Substrate Binding Site II [chemical binding]; other site 545693012604 Substrate Binding Site I [chemical binding]; other site 545693012605 EcsC protein family; Region: EcsC; pfam12787 545693012606 Acetokinase family; Region: Acetate_kinase; cl01029 545693012607 propionate/acetate kinase; Provisional; Region: PRK12379 545693012608 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 545693012609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693012610 S-adenosylmethionine binding site [chemical binding]; other site 545693012611 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 545693012612 dimer interface [polypeptide binding]; other site 545693012613 catalytic triad [active] 545693012614 peroxidatic and resolving cysteines [active] 545693012615 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 545693012616 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 545693012617 RDD family; Region: RDD; cl00746 545693012618 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 545693012619 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 545693012620 tandem repeat interface [polypeptide binding]; other site 545693012621 oligomer interface [polypeptide binding]; other site 545693012622 active site residues [active] 545693012623 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 545693012624 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 545693012625 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 545693012626 active site 545693012627 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 545693012628 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 545693012629 THUMP domain; Region: THUMP; cl12076 545693012630 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 545693012631 Ligand Binding Site [chemical binding]; other site 545693012632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 545693012633 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 545693012634 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693012635 catalytic residue [active] 545693012636 septation ring formation regulator EzrA; Provisional; Region: PRK04778 545693012637 histidinol-phosphatase; Reviewed; Region: PRK08123 545693012638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693012639 Helix-turn-helix domains; Region: HTH; cl00088 545693012640 GAF domain; Region: GAF; cl15785 545693012641 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 545693012642 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 545693012643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693012644 RNA binding surface [nucleotide binding]; other site 545693012645 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 545693012646 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 545693012647 active site 545693012648 HIGH motif; other site 545693012649 dimer interface [polypeptide binding]; other site 545693012650 KMSKS motif; other site 545693012651 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693012652 RNA binding surface [nucleotide binding]; other site 545693012653 acetyl-CoA synthetase; Provisional; Region: PRK04319 545693012654 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 545693012655 AMP-binding enzyme; Region: AMP-binding; cl15778 545693012656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693012657 FOG: CBS domain [General function prediction only]; Region: COG0517 545693012658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 545693012659 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 545693012660 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 545693012661 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 545693012662 flagellar motor protein MotS; Reviewed; Region: PRK06925 545693012663 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 545693012664 ligand binding site [chemical binding]; other site 545693012665 flagellar motor protein MotP; Reviewed; Region: PRK06926 545693012666 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 545693012667 catabolite control protein A; Region: ccpA; TIGR01481 545693012668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693012669 DNA binding site [nucleotide binding] 545693012670 domain linker motif; other site 545693012671 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 545693012672 dimerization interface [polypeptide binding]; other site 545693012673 effector binding site; other site 545693012674 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 545693012675 Chorismate mutase type II; Region: CM_2; cl00693 545693012676 NeuB family; Region: NeuB; cl00496 545693012677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693012678 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 545693012679 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 545693012680 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 545693012681 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 545693012682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 545693012683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 545693012684 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 545693012685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693012686 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 545693012687 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 545693012688 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 545693012689 putative tRNA-binding site [nucleotide binding]; other site 545693012690 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 545693012691 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693012692 catalytic residues [active] 545693012693 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 545693012694 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 545693012695 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 545693012696 oligomer interface [polypeptide binding]; other site 545693012697 active site 545693012698 metal binding site [ion binding]; metal-binding site 545693012699 Predicted small secreted protein [Function unknown]; Region: COG5584 545693012700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693012701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693012702 S-adenosylmethionine binding site [chemical binding]; other site 545693012703 YtzH-like protein; Region: YtzH; pfam14165 545693012704 Phosphotransferase enzyme family; Region: APH; pfam01636 545693012705 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 545693012706 active site 545693012707 substrate binding site [chemical binding]; other site 545693012708 ATP binding site [chemical binding]; other site 545693012709 pullulanase, type I; Region: pulA_typeI; TIGR02104 545693012710 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 545693012711 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 545693012712 Ca binding site [ion binding]; other site 545693012713 active site 545693012714 catalytic site [active] 545693012715 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 545693012716 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 545693012717 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693012718 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 545693012719 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 545693012720 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 545693012721 dimer interface [polypeptide binding]; other site 545693012722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012723 catalytic residue [active] 545693012724 dipeptidase PepV; Reviewed; Region: PRK07318 545693012725 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 545693012726 active site 545693012727 metal binding site [ion binding]; metal-binding site 545693012728 Helix-turn-helix domains; Region: HTH; cl00088 545693012729 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 545693012730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 545693012731 RNA binding surface [nucleotide binding]; other site 545693012732 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 545693012733 active site 545693012734 uracil binding [chemical binding]; other site 545693012735 stage V sporulation protein B; Region: spore_V_B; TIGR02900 545693012736 MatE; Region: MatE; cl10513 545693012737 HI0933-like protein; Region: HI0933_like; pfam03486 545693012738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012740 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 545693012741 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 545693012742 active site residue [active] 545693012743 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 545693012744 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 545693012745 HIGH motif; other site 545693012746 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 545693012747 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 545693012748 active site 545693012749 KMSKS motif; other site 545693012750 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 545693012751 tRNA binding surface [nucleotide binding]; other site 545693012752 Citrate transporter; Region: CitMHS; pfam03600 545693012753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693012754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 545693012755 putative substrate translocation pore; other site 545693012756 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 545693012757 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 545693012758 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693012759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693012760 S-adenosylmethionine binding site [chemical binding]; other site 545693012761 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 545693012762 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 545693012763 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693012764 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 545693012765 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 545693012766 trimer interface [polypeptide binding]; other site 545693012767 putative metal binding site [ion binding]; other site 545693012768 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 545693012769 active site 545693012770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693012771 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 545693012772 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 545693012773 S-adenosylmethionine synthetase; Validated; Region: PRK05250 545693012774 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 545693012775 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 545693012776 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 545693012777 active site 545693012778 substrate-binding site [chemical binding]; other site 545693012779 metal-binding site [ion binding] 545693012780 ATP binding site [chemical binding]; other site 545693012781 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 545693012782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693012783 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693012784 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 545693012785 NMT1-like family; Region: NMT1_2; cl15260 545693012786 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 545693012787 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 545693012788 Walker A/P-loop; other site 545693012789 ATP binding site [chemical binding]; other site 545693012790 Q-loop/lid; other site 545693012791 ABC transporter signature motif; other site 545693012792 Walker B; other site 545693012793 D-loop; other site 545693012794 H-loop/switch region; other site 545693012795 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 545693012796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 545693012797 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 545693012798 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 545693012799 nudix motif; other site 545693012800 Holin family; Region: Phage_holin_4; cl01989 545693012801 Ferritin-like domain; Region: Ferritin; pfam00210 545693012802 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 545693012803 dimerization interface [polypeptide binding]; other site 545693012804 DPS ferroxidase diiron center [ion binding]; other site 545693012805 ion pore; other site 545693012806 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 545693012807 Haemolytic domain; Region: Haemolytic; cl00506 545693012808 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 545693012809 active site clefts [active] 545693012810 zinc binding site [ion binding]; other site 545693012811 dimer interface [polypeptide binding]; other site 545693012812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693012813 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 545693012814 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 545693012815 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 545693012816 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 545693012817 metal binding site [ion binding]; metal-binding site 545693012818 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 545693012819 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 545693012820 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 545693012821 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693012822 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 545693012823 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 545693012824 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 545693012825 dimer interface [polypeptide binding]; other site 545693012826 putative radical transfer pathway; other site 545693012827 diiron center [ion binding]; other site 545693012828 tyrosyl radical; other site 545693012829 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 545693012830 Class I ribonucleotide reductase; Region: RNR_I; cd01679 545693012831 active site 545693012832 dimer interface [polypeptide binding]; other site 545693012833 catalytic residues [active] 545693012834 effector binding site; other site 545693012835 R2 peptide binding site; other site 545693012836 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 545693012837 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 545693012838 active site 545693012839 octamer interface [polypeptide binding]; other site 545693012840 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 545693012841 AMP-binding enzyme; Region: AMP-binding; cl15778 545693012842 AMP-binding enzyme; Region: AMP-binding; cl15778 545693012843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693012844 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 545693012845 substrate binding site [chemical binding]; other site 545693012846 oxyanion hole (OAH) forming residues; other site 545693012847 trimer interface [polypeptide binding]; other site 545693012848 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 545693012849 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693012850 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 545693012851 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 545693012852 dimer interface [polypeptide binding]; other site 545693012853 tetramer interface [polypeptide binding]; other site 545693012854 PYR/PP interface [polypeptide binding]; other site 545693012855 TPP binding site [chemical binding]; other site 545693012856 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 545693012857 TPP-binding site; other site 545693012858 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 545693012859 chorismate binding enzyme; Region: Chorismate_bind; cl10555 545693012860 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 545693012861 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 545693012862 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 545693012863 homodimer interface [polypeptide binding]; other site 545693012864 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 545693012865 active site pocket [active] 545693012866 glycogen synthase; Provisional; Region: glgA; PRK00654 545693012867 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 545693012868 ADP-binding pocket [chemical binding]; other site 545693012869 homodimer interface [polypeptide binding]; other site 545693012870 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 545693012871 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 545693012872 ligand binding site; other site 545693012873 oligomer interface; other site 545693012874 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 545693012875 dimer interface [polypeptide binding]; other site 545693012876 N-terminal domain interface [polypeptide binding]; other site 545693012877 sulfate 1 binding site; other site 545693012878 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 545693012879 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 545693012880 ligand binding site; other site 545693012881 oligomer interface; other site 545693012882 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 545693012883 dimer interface [polypeptide binding]; other site 545693012884 N-terminal domain interface [polypeptide binding]; other site 545693012885 sulfate 1 binding site; other site 545693012886 glycogen branching enzyme; Provisional; Region: PRK12313 545693012887 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 545693012888 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 545693012889 active site 545693012890 catalytic site [active] 545693012891 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 545693012892 AMP-binding domain protein; Validated; Region: PRK08315 545693012893 AMP-binding enzyme; Region: AMP-binding; cl15778 545693012894 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693012895 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 545693012896 MgtC family; Region: MgtC; pfam02308 545693012897 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 545693012898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012899 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 545693012900 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 545693012901 putative active site [active] 545693012902 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 545693012903 putative active site [active] 545693012904 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 545693012905 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 545693012906 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 545693012907 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 545693012908 ligand-binding site [chemical binding]; other site 545693012909 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 545693012910 ATP-sulfurylase; Region: ATPS; cd00517 545693012911 active site 545693012912 HXXH motif; other site 545693012913 flexible loop; other site 545693012914 Phosphate transporter family; Region: PHO4; cl00396 545693012915 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 545693012916 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 545693012917 Active Sites [active] 545693012918 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 545693012919 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 545693012920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693012921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 545693012922 active site 545693012923 metal binding site [ion binding]; metal-binding site 545693012924 Ion channel; Region: Ion_trans_2; cl11596 545693012925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012926 YugN-like family; Region: YugN; pfam08868 545693012927 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 545693012928 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 545693012929 active site 545693012930 dimer interface [polypeptide binding]; other site 545693012931 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 545693012932 dimer interface [polypeptide binding]; other site 545693012933 active site 545693012934 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 545693012935 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 545693012936 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 545693012937 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 545693012938 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 545693012939 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 545693012940 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 545693012941 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 545693012942 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 545693012943 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 545693012944 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 545693012945 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 545693012946 dimer interface [polypeptide binding]; other site 545693012947 active site 545693012948 metal binding site [ion binding]; metal-binding site 545693012949 Domain of unknown function (DUF378); Region: DUF378; cl00943 545693012950 general stress protein 13; Validated; Region: PRK08059 545693012951 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 545693012952 RNA binding site [nucleotide binding]; other site 545693012953 hypothetical protein; Validated; Region: PRK07682 545693012954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693012955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012956 homodimer interface [polypeptide binding]; other site 545693012957 catalytic residue [active] 545693012958 Helix-turn-helix domains; Region: HTH; cl00088 545693012959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693012960 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 545693012961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693012962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693012963 homodimer interface [polypeptide binding]; other site 545693012964 catalytic residue [active] 545693012965 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 545693012966 E-class dimer interface [polypeptide binding]; other site 545693012967 P-class dimer interface [polypeptide binding]; other site 545693012968 active site 545693012969 Cu2+ binding site [ion binding]; other site 545693012970 Zn2+ binding site [ion binding]; other site 545693012971 Kinase associated protein B; Region: KapB; pfam08810 545693012972 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 545693012973 active site 545693012974 catalytic site [active] 545693012975 substrate binding site [chemical binding]; other site 545693012976 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 545693012977 CoenzymeA binding site [chemical binding]; other site 545693012978 subunit interaction site [polypeptide binding]; other site 545693012979 PHB binding site; other site 545693012980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693012981 Predicted permease [General function prediction only]; Region: COG2056 545693012982 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 545693012983 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 545693012984 multifunctional aminopeptidase A; Provisional; Region: PRK00913 545693012985 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 545693012986 interface (dimer of trimers) [polypeptide binding]; other site 545693012987 Substrate-binding/catalytic site; other site 545693012988 Zn-binding sites [ion binding]; other site 545693012989 Divergent PAP2 family; Region: DUF212; cl00855 545693012990 3D domain; Region: 3D; cl01439 545693012991 Putative membrane protein; Region: YuiB; pfam14068 545693012992 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693012993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693012994 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 545693012995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693012996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693012997 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 545693012998 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 545693012999 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 545693013000 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 545693013001 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 545693013002 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 545693013003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013004 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 545693013005 NifU-like domain; Region: NifU; cl00484 545693013006 homoserine kinase; Provisional; Region: PRK01212 545693013007 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 545693013008 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 545693013009 threonine synthase; Reviewed; Region: PRK06721 545693013010 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693013011 homodimer interface [polypeptide binding]; other site 545693013012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693013013 catalytic residue [active] 545693013014 homoserine dehydrogenase; Provisional; Region: PRK06349 545693013015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013016 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 545693013017 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 545693013018 glyoxylate reductase; Reviewed; Region: PRK13243 545693013019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693013021 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 545693013022 tetramer interfaces [polypeptide binding]; other site 545693013023 binuclear metal-binding site [ion binding]; other site 545693013024 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 545693013025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013026 active site 545693013027 motif I; other site 545693013028 motif II; other site 545693013029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013030 Protein of unknown function DUF86; Region: DUF86; cl01031 545693013031 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 545693013032 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 545693013033 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 545693013034 lipoyl synthase; Provisional; Region: PRK05481 545693013035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693013036 FeS/SAM binding site; other site 545693013037 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693013038 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 545693013039 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 545693013040 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 545693013041 Protein of unknown function DUF72; Region: DUF72; cl00777 545693013042 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 545693013043 FeS assembly protein SufB; Region: sufB; TIGR01980 545693013044 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 545693013045 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 545693013046 trimerization site [polypeptide binding]; other site 545693013047 active site 545693013048 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 545693013049 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 545693013050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 545693013051 catalytic residue [active] 545693013052 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 545693013053 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 545693013054 FeS assembly ATPase SufC; Region: sufC; TIGR01978 545693013055 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 545693013056 Walker A/P-loop; other site 545693013057 ATP binding site [chemical binding]; other site 545693013058 Q-loop/lid; other site 545693013059 ABC transporter signature motif; other site 545693013060 Walker B; other site 545693013061 D-loop; other site 545693013062 H-loop/switch region; other site 545693013063 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 545693013064 NMT1-like family; Region: NMT1_2; cl15260 545693013065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693013066 dimer interface [polypeptide binding]; other site 545693013067 conserved gate region; other site 545693013068 putative PBP binding loops; other site 545693013069 ABC-ATPase subunit interface; other site 545693013070 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 545693013071 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 545693013072 Walker A/P-loop; other site 545693013073 ATP binding site [chemical binding]; other site 545693013074 Q-loop/lid; other site 545693013075 ABC transporter signature motif; other site 545693013076 Walker B; other site 545693013077 D-loop; other site 545693013078 H-loop/switch region; other site 545693013079 NIL domain; Region: NIL; cl09633 545693013080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 545693013081 catalytic residues [active] 545693013082 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 545693013083 active site 545693013084 metal binding site [ion binding]; metal-binding site 545693013085 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 545693013086 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 545693013087 lipoyl attachment site [posttranslational modification]; other site 545693013088 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 545693013089 ArsC family; Region: ArsC; pfam03960 545693013090 putative ArsC-like catalytic residues; other site 545693013091 putative TRX-like catalytic residues [active] 545693013092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 545693013093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693013094 active site 545693013095 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 545693013096 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693013097 dimer interface [polypeptide binding]; other site 545693013098 active site 545693013099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693013101 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693013102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 545693013103 substrate binding site [chemical binding]; other site 545693013104 oxyanion hole (OAH) forming residues; other site 545693013105 trimer interface [polypeptide binding]; other site 545693013106 Proline dehydrogenase; Region: Pro_dh; cl03282 545693013107 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 545693013108 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 545693013109 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 545693013110 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 545693013111 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 545693013112 Walker A/P-loop; other site 545693013113 ATP binding site [chemical binding]; other site 545693013114 Q-loop/lid; other site 545693013115 ABC transporter signature motif; other site 545693013116 Walker B; other site 545693013117 D-loop; other site 545693013118 H-loop/switch region; other site 545693013119 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 545693013120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693013121 ABC-ATPase subunit interface; other site 545693013122 dimer interface [polypeptide binding]; other site 545693013123 putative PBP binding regions; other site 545693013124 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 545693013125 ABC-ATPase subunit interface; other site 545693013126 dimer interface [polypeptide binding]; other site 545693013127 putative PBP binding regions; other site 545693013128 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 545693013129 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 545693013130 siderophore binding site; other site 545693013131 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 545693013132 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 545693013133 Protein export membrane protein; Region: SecD_SecF; cl14618 545693013134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693013135 Helix-turn-helix domains; Region: HTH; cl00088 545693013136 Protein of unknown function (DUF502); Region: DUF502; cl01107 545693013137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013139 benzoate transport; Region: 2A0115; TIGR00895 545693013140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693013141 putative substrate translocation pore; other site 545693013142 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693013143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693013144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693013145 dimer interface [polypeptide binding]; other site 545693013146 phosphorylation site [posttranslational modification] 545693013147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013148 ATP binding site [chemical binding]; other site 545693013149 Mg2+ binding site [ion binding]; other site 545693013150 G-X-G motif; other site 545693013151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693013152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013153 active site 545693013154 phosphorylation site [posttranslational modification] 545693013155 intermolecular recognition site; other site 545693013156 dimerization interface [polypeptide binding]; other site 545693013157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693013158 DNA binding site [nucleotide binding] 545693013159 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 545693013160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693013161 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 545693013162 active site 545693013163 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 545693013164 Helix-turn-helix domains; Region: HTH; cl00088 545693013165 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 545693013166 dimer interface [polypeptide binding]; other site 545693013167 FMN binding site [chemical binding]; other site 545693013168 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 545693013169 MoaE interaction surface [polypeptide binding]; other site 545693013170 MoeB interaction surface [polypeptide binding]; other site 545693013171 thiocarboxylated glycine; other site 545693013172 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 545693013173 MoaE homodimer interface [polypeptide binding]; other site 545693013174 MoaD interaction [polypeptide binding]; other site 545693013175 active site residues [active] 545693013176 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 545693013177 Walker A motif; other site 545693013178 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 545693013179 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 545693013180 dimer interface [polypeptide binding]; other site 545693013181 putative functional site; other site 545693013182 putative MPT binding site; other site 545693013183 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 545693013184 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 545693013185 ATP binding site [chemical binding]; other site 545693013186 substrate interface [chemical binding]; other site 545693013187 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 545693013188 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 545693013189 GTP binding site; other site 545693013190 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 545693013191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 545693013192 FeS/SAM binding site; other site 545693013193 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 545693013194 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 545693013195 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 545693013196 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 545693013197 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 545693013198 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 545693013199 4Fe-4S binding domain; Region: Fer4; cl02805 545693013200 4Fe-4S binding domain; Region: Fer4; cl02805 545693013201 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 545693013202 [4Fe-4S] binding site [ion binding]; other site 545693013203 molybdopterin cofactor binding site; other site 545693013204 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 545693013205 molybdopterin cofactor binding site; other site 545693013206 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 545693013207 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 545693013208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 545693013209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 545693013210 dimer interface [polypeptide binding]; other site 545693013211 conserved gate region; other site 545693013212 putative PBP binding loops; other site 545693013213 ABC-ATPase subunit interface; other site 545693013214 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 545693013215 SmpB-tmRNA interface; other site 545693013216 ribonuclease R; Region: RNase_R; TIGR02063 545693013217 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693013218 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 545693013219 RNB domain; Region: RNB; pfam00773 545693013220 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 545693013221 RNA binding site [nucleotide binding]; other site 545693013222 Esterase/lipase [General function prediction only]; Region: COG1647 545693013223 Preprotein translocase SecG subunit; Region: SecG; cl09123 545693013224 enolase; Provisional; Region: eno; PRK00077 545693013225 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 545693013226 dimer interface [polypeptide binding]; other site 545693013227 metal binding site [ion binding]; metal-binding site 545693013228 substrate binding pocket [chemical binding]; other site 545693013229 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 545693013230 Sulfatase; Region: Sulfatase; cl10460 545693013231 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 545693013232 substrate binding site [chemical binding]; other site 545693013233 dimer interface [polypeptide binding]; other site 545693013234 catalytic triad [active] 545693013235 Phosphoglycerate kinase; Region: PGK; pfam00162 545693013236 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 545693013237 substrate binding site [chemical binding]; other site 545693013238 hinge regions; other site 545693013239 ADP binding site [chemical binding]; other site 545693013240 catalytic site [active] 545693013241 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 545693013242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013243 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 545693013244 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 545693013245 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 545693013246 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 545693013247 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 545693013248 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 545693013249 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 545693013250 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 545693013251 Clp protease; Region: CLP_protease; pfam00574 545693013252 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 545693013253 oligomer interface [polypeptide binding]; other site 545693013254 active site residues [active] 545693013255 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 545693013256 dimerization domain swap beta strand [polypeptide binding]; other site 545693013257 regulatory protein interface [polypeptide binding]; other site 545693013258 active site 545693013259 regulatory phosphorylation site [posttranslational modification]; other site 545693013260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 545693013261 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 545693013262 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 545693013263 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 545693013264 phosphate binding site [ion binding]; other site 545693013265 putative substrate binding pocket [chemical binding]; other site 545693013266 dimer interface [polypeptide binding]; other site 545693013267 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 545693013268 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 545693013269 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 545693013270 putative active site [active] 545693013271 nucleotide binding site [chemical binding]; other site 545693013272 nudix motif; other site 545693013273 putative metal binding site [ion binding]; other site 545693013274 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 545693013275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 545693013277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693013278 binding surface 545693013279 TPR motif; other site 545693013280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693013281 binding surface 545693013282 Tetratricopeptide repeat; Region: TPR_16; pfam13432 545693013283 TPR motif; other site 545693013284 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 545693013285 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 545693013286 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 545693013287 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 545693013288 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 545693013289 substrate binding site [chemical binding]; other site 545693013290 glutamase interaction surface [polypeptide binding]; other site 545693013291 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 545693013292 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 545693013293 catalytic residues [active] 545693013294 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 545693013295 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 545693013296 putative active site [active] 545693013297 oxyanion strand; other site 545693013298 catalytic triad [active] 545693013299 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 545693013300 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 545693013301 putative active site pocket [active] 545693013302 4-fold oligomerization interface [polypeptide binding]; other site 545693013303 metal binding residues [ion binding]; metal-binding site 545693013304 3-fold/trimer interface [polypeptide binding]; other site 545693013305 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 545693013306 histidinol dehydrogenase; Region: hisD; TIGR00069 545693013307 NAD binding site [chemical binding]; other site 545693013308 dimerization interface [polypeptide binding]; other site 545693013309 product binding site; other site 545693013310 substrate binding site [chemical binding]; other site 545693013311 zinc binding site [ion binding]; other site 545693013312 catalytic residues [active] 545693013313 ATP phosphoribosyltransferase; Region: HisG; cl15266 545693013314 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 545693013315 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 545693013316 dimer interface [polypeptide binding]; other site 545693013317 motif 1; other site 545693013318 active site 545693013319 motif 2; other site 545693013320 motif 3; other site 545693013321 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 545693013322 trimer interface [polypeptide binding]; other site 545693013323 active site 545693013324 substrate binding site [chemical binding]; other site 545693013325 CoA binding site [chemical binding]; other site 545693013326 pyrophosphatase PpaX; Provisional; Region: PRK13288 545693013327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013328 motif II; other site 545693013329 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 545693013330 HPr kinase/phosphorylase; Provisional; Region: PRK05428 545693013331 DRTGG domain; Region: DRTGG; cl12147 545693013332 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 545693013333 Hpr binding site; other site 545693013334 active site 545693013335 homohexamer subunit interaction site [polypeptide binding]; other site 545693013336 Membrane protein of unknown function; Region: DUF360; cl00850 545693013337 PspC domain; Region: PspC; cl00864 545693013338 Uncharacterized conserved protein [Function unknown]; Region: COG3595 545693013339 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 545693013340 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 545693013341 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 545693013342 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 545693013343 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 545693013344 excinuclease ABC subunit B; Provisional; Region: PRK05298 545693013345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693013346 ATP binding site [chemical binding]; other site 545693013347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693013348 nucleotide binding region [chemical binding]; other site 545693013349 ATP-binding site [chemical binding]; other site 545693013350 Ultra-violet resistance protein B; Region: UvrB; pfam12344 545693013351 sensory histidine kinase AtoS; Provisional; Region: PRK11360 545693013352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693013353 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 545693013354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 545693013355 Walker A motif; other site 545693013356 ATP binding site [chemical binding]; other site 545693013357 Walker B motif; other site 545693013358 arginine finger; other site 545693013359 Helix-turn-helix domains; Region: HTH; cl00088 545693013360 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 545693013361 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 545693013362 Glutamate binding site [chemical binding]; other site 545693013363 homodimer interface [polypeptide binding]; other site 545693013364 NAD binding site [chemical binding]; other site 545693013365 catalytic residues [active] 545693013366 Proline dehydrogenase; Region: Pro_dh; cl03282 545693013367 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 545693013368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693013369 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 545693013370 C-terminal peptidase (prc); Region: prc; TIGR00225 545693013371 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 545693013372 protein binding site [polypeptide binding]; other site 545693013373 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 545693013374 Catalytic dyad [active] 545693013375 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 545693013376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 545693013377 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693013378 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 545693013379 FtsX-like permease family; Region: FtsX; cl15850 545693013380 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 545693013381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693013382 Walker A/P-loop; other site 545693013383 ATP binding site [chemical binding]; other site 545693013384 Q-loop/lid; other site 545693013385 ABC transporter signature motif; other site 545693013386 Walker B; other site 545693013387 D-loop; other site 545693013388 H-loop/switch region; other site 545693013389 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 545693013390 Cytochrome c; Region: Cytochrom_C; cl11414 545693013391 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 545693013392 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 545693013393 PhoD-like phosphatase; Region: PhoD; pfam09423 545693013394 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 545693013395 putative active site [active] 545693013396 putative metal binding site [ion binding]; other site 545693013397 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 545693013398 peptide chain release factor 2; Provisional; Region: PRK06746 545693013399 RF-1 domain; Region: RF-1; cl02875 545693013400 RF-1 domain; Region: RF-1; cl02875 545693013401 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 545693013402 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 545693013403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693013404 nucleotide binding region [chemical binding]; other site 545693013405 ATP-binding site [chemical binding]; other site 545693013406 SEC-C motif; Region: SEC-C; pfam02810 545693013407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693013408 Coenzyme A binding pocket [chemical binding]; other site 545693013409 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 545693013410 30S subunit binding site; other site 545693013411 Flagellar protein FliS; Region: FliS; cl00654 545693013412 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 545693013413 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 545693013414 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 545693013415 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 545693013416 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 545693013417 Sodium:solute symporter family; Region: SSF; cl00456 545693013418 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 545693013419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 545693013420 tetramerization interface [polypeptide binding]; other site 545693013421 NAD(P) binding site [chemical binding]; other site 545693013422 catalytic residues [active] 545693013423 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 545693013424 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 545693013425 active site 545693013426 NAD binding site [chemical binding]; other site 545693013427 metal binding site [ion binding]; metal-binding site 545693013428 Predicted transcriptional regulators [Transcription]; Region: COG1510 545693013429 Global regulator protein family; Region: CsrA; cl00670 545693013430 FliW protein; Region: FliW; cl00740 545693013431 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 545693013432 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 545693013433 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 545693013434 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 545693013435 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693013436 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 545693013437 FlgN protein; Region: FlgN; cl09176 545693013438 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 545693013439 flagellar operon protein TIGR03826; Region: YvyF 545693013440 comF family protein; Region: comF; TIGR00201 545693013441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693013442 active site 545693013443 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 545693013444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693013445 ATP binding site [chemical binding]; other site 545693013446 putative Mg++ binding site [ion binding]; other site 545693013447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693013448 nucleotide binding region [chemical binding]; other site 545693013449 ATP-binding site [chemical binding]; other site 545693013450 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 545693013451 Protein of unknown function (DUF327); Region: DUF327; cl00753 545693013452 Flagellar protein FliS; Region: FliS; cl00654 545693013453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693013454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013455 active site 545693013456 phosphorylation site [posttranslational modification] 545693013457 intermolecular recognition site; other site 545693013458 dimerization interface [polypeptide binding]; other site 545693013459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693013460 DNA binding residues [nucleotide binding] 545693013461 dimerization interface [polypeptide binding]; other site 545693013462 Sensor protein DegS; Region: DegS; pfam05384 545693013463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 545693013464 Histidine kinase; Region: HisKA_3; pfam07730 545693013465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013466 ATP binding site [chemical binding]; other site 545693013467 Mg2+ binding site [ion binding]; other site 545693013468 G-X-G motif; other site 545693013469 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 545693013470 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 545693013471 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 545693013472 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 545693013473 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 545693013474 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 545693013475 Mg++ binding site [ion binding]; other site 545693013476 putative catalytic motif [active] 545693013477 substrate binding site [chemical binding]; other site 545693013478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 545693013479 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 545693013480 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 545693013481 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 545693013482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013483 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 545693013484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013485 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 545693013486 active site 545693013487 tetramer interface; other site 545693013488 Uncharacterized conserved protein [Function unknown]; Region: COG4715 545693013489 SNF2 Helicase protein; Region: DUF3670; pfam12419 545693013490 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 545693013491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 545693013492 ATP binding site [chemical binding]; other site 545693013493 putative Mg++ binding site [ion binding]; other site 545693013494 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 545693013495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 545693013496 nucleotide binding region [chemical binding]; other site 545693013497 ATP-binding site [chemical binding]; other site 545693013498 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693013499 putative peptidoglycan binding site; other site 545693013500 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 545693013501 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693013502 putative peptidoglycan binding site; other site 545693013503 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 545693013504 putative peptidoglycan binding site; other site 545693013505 NlpC/P60 family; Region: NLPC_P60; cl11438 545693013506 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 545693013507 dimer interface [polypeptide binding]; other site 545693013508 ssDNA binding site [nucleotide binding]; other site 545693013509 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693013510 YwpF-like protein; Region: YwpF; pfam14183 545693013511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693013512 non-specific DNA binding site [nucleotide binding]; other site 545693013513 salt bridge; other site 545693013514 sequence-specific DNA binding site [nucleotide binding]; other site 545693013515 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693013516 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 545693013517 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693013518 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 545693013519 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 545693013520 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 545693013521 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 545693013522 rod shape-determining protein Mbl; Provisional; Region: PRK13928 545693013523 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 545693013524 ATP binding site [chemical binding]; other site 545693013525 profilin binding site; other site 545693013526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693013527 Peptidase family M23; Region: Peptidase_M23; pfam01551 545693013528 stage II sporulation protein D; Region: spore_II_D; TIGR02870 545693013529 Stage II sporulation protein; Region: SpoIID; pfam08486 545693013530 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 545693013531 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 545693013532 hinge; other site 545693013533 active site 545693013534 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 545693013535 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 545693013536 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 545693013537 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 545693013538 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 545693013539 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 545693013540 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 545693013541 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 545693013542 alpha subunit interaction interface [polypeptide binding]; other site 545693013543 Walker A motif; other site 545693013544 ATP binding site [chemical binding]; other site 545693013545 Walker B motif; other site 545693013546 inhibitor binding site; inhibition site 545693013547 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 545693013548 ATP synthase; Region: ATP-synt; cl00365 545693013549 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 545693013550 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 545693013551 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 545693013552 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 545693013553 beta subunit interaction interface [polypeptide binding]; other site 545693013554 Walker A motif; other site 545693013555 ATP binding site [chemical binding]; other site 545693013556 Walker B motif; other site 545693013557 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 545693013558 Plant ATP synthase F0; Region: YMF19; cl07975 545693013559 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 545693013560 Plant ATP synthase F0; Region: YMF19; cl07975 545693013561 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 545693013562 ATP synthase subunit C; Region: ATP-synt_C; cl00466 545693013563 ATP synthase A chain; Region: ATP-synt_A; cl00413 545693013564 ATP synthase I chain; Region: ATP_synt_I; cl09170 545693013565 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 545693013566 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693013567 putative active site [active] 545693013568 catalytic triad [active] 545693013569 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 545693013570 PA/protease or protease-like domain interface [polypeptide binding]; other site 545693013571 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 545693013572 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 545693013573 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 545693013574 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 545693013575 active site 545693013576 homodimer interface [polypeptide binding]; other site 545693013577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 545693013578 active site 545693013579 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 545693013580 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 545693013581 dimer interface [polypeptide binding]; other site 545693013582 active site 545693013583 glycine-pyridoxal phosphate binding site [chemical binding]; other site 545693013584 folate binding site [chemical binding]; other site 545693013585 Protein of unknown function (DUF436); Region: DUF436; cl01860 545693013586 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 545693013587 Low molecular weight phosphatase family; Region: LMWPc; cd00115 545693013588 active site 545693013589 Predicted membrane protein [Function unknown]; Region: COG1971 545693013590 Domain of unknown function DUF; Region: DUF204; pfam02659 545693013591 Domain of unknown function DUF; Region: DUF204; pfam02659 545693013592 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 545693013593 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 545693013594 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693013595 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 545693013596 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 545693013597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693013598 S-adenosylmethionine binding site [chemical binding]; other site 545693013599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013600 peptide chain release factor 1; Validated; Region: prfA; PRK00591 545693013601 RF-1 domain; Region: RF-1; cl02875 545693013602 RF-1 domain; Region: RF-1; cl02875 545693013603 thymidine kinase; Provisional; Region: PRK04296 545693013604 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 545693013605 transcription termination factor Rho; Provisional; Region: rho; PRK09376 545693013606 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 545693013607 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 545693013608 RNA binding site [nucleotide binding]; other site 545693013609 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 545693013610 multimer interface [polypeptide binding]; other site 545693013611 Walker A motif; other site 545693013612 ATP binding site [chemical binding]; other site 545693013613 Walker B motif; other site 545693013614 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 545693013615 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 545693013616 hinge; other site 545693013617 active site 545693013618 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 545693013619 active site 545693013620 intersubunit interactions; other site 545693013621 catalytic residue [active] 545693013622 hypothetical protein; Provisional; Region: PRK08185 545693013623 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 545693013624 intersubunit interface [polypeptide binding]; other site 545693013625 active site 545693013626 zinc binding site [ion binding]; other site 545693013627 Na+ binding site [ion binding]; other site 545693013628 Response regulator receiver domain; Region: Response_reg; pfam00072 545693013629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013630 active site 545693013631 phosphorylation site [posttranslational modification] 545693013632 intermolecular recognition site; other site 545693013633 dimerization interface [polypeptide binding]; other site 545693013634 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 545693013635 CTP synthetase; Validated; Region: pyrG; PRK05380 545693013636 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 545693013637 Catalytic site [active] 545693013638 active site 545693013639 UTP binding site [chemical binding]; other site 545693013640 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 545693013641 active site 545693013642 putative oxyanion hole; other site 545693013643 catalytic triad [active] 545693013644 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 545693013645 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 545693013646 B12 binding site [chemical binding]; other site 545693013647 cobalt ligand [ion binding]; other site 545693013648 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 545693013649 Walker A; other site 545693013650 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 545693013651 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 545693013652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693013653 Helix-turn-helix domains; Region: HTH; cl00088 545693013654 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693013655 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 545693013656 FAD binding site [chemical binding]; other site 545693013657 homotetramer interface [polypeptide binding]; other site 545693013658 substrate binding pocket [chemical binding]; other site 545693013659 catalytic base [active] 545693013660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 545693013661 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 545693013662 FAD binding site [chemical binding]; other site 545693013663 homotetramer interface [polypeptide binding]; other site 545693013664 substrate binding pocket [chemical binding]; other site 545693013665 catalytic base [active] 545693013666 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 545693013667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013668 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 545693013669 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 545693013670 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 545693013671 dimer interface [polypeptide binding]; other site 545693013672 active site 545693013673 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 545693013674 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 545693013675 Cysteine-rich domain; Region: CCG; pfam02754 545693013676 Cysteine-rich domain; Region: CCG; pfam02754 545693013677 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 545693013678 putative active site [active] 545693013679 catalytic site [active] 545693013680 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 545693013681 PLD-like domain; Region: PLDc_2; pfam13091 545693013682 putative active site [active] 545693013683 catalytic site [active] 545693013684 UV-endonuclease UvdE; Region: UvdE; cl10036 545693013685 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 545693013686 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 545693013687 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 545693013688 active site 545693013689 HIGH motif; other site 545693013690 KMSK motif region; other site 545693013691 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 545693013692 tRNA binding surface [nucleotide binding]; other site 545693013693 anticodon binding site; other site 545693013694 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 545693013695 Arginase family; Region: Arginase; cl00306 545693013696 spermidine synthase; Provisional; Region: PRK00811 545693013697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693013698 Transglycosylase; Region: Transgly; cl07896 545693013699 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 545693013700 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 545693013701 YwhD family; Region: YwhD; pfam08741 545693013702 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 545693013703 active site 545693013704 putative substrate binding region [chemical binding]; other site 545693013705 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 545693013706 active site 1 [active] 545693013707 dimer interface [polypeptide binding]; other site 545693013708 hexamer interface [polypeptide binding]; other site 545693013709 active site 2 [active] 545693013710 Uncharacterized conserved protein [Function unknown]; Region: COG3465 545693013711 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 545693013712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 545693013713 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 545693013714 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 545693013715 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 545693013716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 545693013717 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 545693013718 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 545693013719 Chlorite dismutase; Region: Chlor_dismutase; cl01280 545693013720 cell wall hydrolase CwlJ, frameshift 545693013721 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 545693013722 Protein of unknown function (DUF423); Region: DUF423; cl01008 545693013723 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 545693013724 ligand binding site [chemical binding]; other site 545693013725 active site 545693013726 UGI interface [polypeptide binding]; other site 545693013727 catalytic site [active] 545693013728 Staygreen protein; Region: Staygreen; pfam12638 545693013729 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 545693013730 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 545693013731 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 545693013732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013733 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 545693013734 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 545693013735 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 545693013736 Helix-turn-helix domains; Region: HTH; cl00088 545693013737 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 545693013738 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 545693013739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013740 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 545693013741 dimer interface [polypeptide binding]; other site 545693013742 substrate binding site [chemical binding]; other site 545693013743 ATP binding site [chemical binding]; other site 545693013744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013745 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 545693013746 active site 545693013747 motif I; other site 545693013748 motif II; other site 545693013749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013750 motif II; other site 545693013751 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693013752 beta-phosphoglucomutase; Region: bPGM; TIGR01990 545693013753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 545693013754 motif II; other site 545693013755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 545693013756 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 545693013757 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 545693013758 active site turn [active] 545693013759 phosphorylation site [posttranslational modification] 545693013760 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 545693013761 putative catalytic site [active] 545693013762 putative metal binding site [ion binding]; other site 545693013763 putative phosphate binding site [ion binding]; other site 545693013764 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 545693013765 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 545693013766 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 545693013767 Ligand binding site; other site 545693013768 Putative Catalytic site; other site 545693013769 DXD motif; other site 545693013770 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 545693013771 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 545693013772 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 545693013773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013774 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 545693013775 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693013776 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 545693013777 Walker A/P-loop; other site 545693013778 ATP binding site [chemical binding]; other site 545693013779 Q-loop/lid; other site 545693013780 ABC transporter signature motif; other site 545693013781 Walker B; other site 545693013782 D-loop; other site 545693013783 H-loop/switch region; other site 545693013784 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 545693013785 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 545693013786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693013787 Walker A/P-loop; other site 545693013788 ATP binding site [chemical binding]; other site 545693013789 Q-loop/lid; other site 545693013790 ABC transporter signature motif; other site 545693013791 Walker B; other site 545693013792 D-loop; other site 545693013793 H-loop/switch region; other site 545693013794 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 545693013795 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 545693013796 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 545693013797 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 545693013798 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 545693013799 Uncharacterized conserved protein [Function unknown]; Region: COG2966 545693013800 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 545693013801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 545693013802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 545693013803 DNA binding site [nucleotide binding] 545693013804 domain linker motif; other site 545693013805 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 545693013806 dimerization interface [polypeptide binding]; other site 545693013807 ligand binding site [chemical binding]; other site 545693013808 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693013809 Putative esterase; Region: Esterase; pfam00756 545693013810 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 545693013811 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 545693013812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693013813 putative substrate translocation pore; other site 545693013814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693013815 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 545693013816 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 545693013817 putative catalytic cysteine [active] 545693013818 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 545693013819 nucleotide binding site [chemical binding]; other site 545693013820 homotetrameric interface [polypeptide binding]; other site 545693013821 putative phosphate binding site [ion binding]; other site 545693013822 putative allosteric binding site; other site 545693013823 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 545693013824 Carbon starvation protein CstA; Region: CstA; pfam02554 545693013825 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 545693013826 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 545693013827 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 545693013828 tetramer interface [polypeptide binding]; other site 545693013829 heme binding pocket [chemical binding]; other site 545693013830 NADPH binding site [chemical binding]; other site 545693013831 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 545693013832 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 545693013833 active site 545693013834 Na/Ca binding site [ion binding]; other site 545693013835 catalytic site [active] 545693013836 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 545693013837 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 545693013838 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 545693013839 transmembrane helices; other site 545693013840 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 545693013841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 545693013842 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013843 Predicted membrane protein [Function unknown]; Region: COG3212 545693013844 Predicted membrane protein [Function unknown]; Region: COG3212 545693013845 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693013847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013848 active site 545693013849 phosphorylation site [posttranslational modification] 545693013850 intermolecular recognition site; other site 545693013851 dimerization interface [polypeptide binding]; other site 545693013852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693013853 DNA binding site [nucleotide binding] 545693013854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 545693013855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 545693013856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693013857 dimer interface [polypeptide binding]; other site 545693013858 phosphorylation site [posttranslational modification] 545693013859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013860 ATP binding site [chemical binding]; other site 545693013861 Mg2+ binding site [ion binding]; other site 545693013862 G-X-G motif; other site 545693013863 Predicted membrane protein [Function unknown]; Region: COG3212 545693013864 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013865 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013866 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013867 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693013868 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 545693013869 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 545693013870 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 545693013871 FMN binding site [chemical binding]; other site 545693013872 active site 545693013873 catalytic residues [active] 545693013874 substrate binding site [chemical binding]; other site 545693013875 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 545693013876 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 545693013877 YyzF-like protein; Region: YyzF; cl15733 545693013878 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 545693013879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 545693013880 protein binding site [polypeptide binding]; other site 545693013881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 545693013882 YycH protein; Region: YycI; cl02015 545693013883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 545693013884 YycH protein; Region: YycH; pfam07435 545693013885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 545693013886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693013887 dimerization interface [polypeptide binding]; other site 545693013888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 545693013889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693013890 dimer interface [polypeptide binding]; other site 545693013891 phosphorylation site [posttranslational modification] 545693013892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693013893 ATP binding site [chemical binding]; other site 545693013894 Mg2+ binding site [ion binding]; other site 545693013895 G-X-G motif; other site 545693013896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693013897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693013898 active site 545693013899 phosphorylation site [posttranslational modification] 545693013900 intermolecular recognition site; other site 545693013901 dimerization interface [polypeptide binding]; other site 545693013902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693013903 DNA binding site [nucleotide binding] 545693013904 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 545693013905 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 545693013906 GDP-binding site [chemical binding]; other site 545693013907 ACT binding site; other site 545693013908 IMP binding site; other site 545693013909 replicative DNA helicase; Provisional; Region: PRK05748 545693013910 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 545693013911 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 545693013912 Walker A motif; other site 545693013913 ATP binding site [chemical binding]; other site 545693013914 Walker B motif; other site 545693013915 DNA binding loops [nucleotide binding] 545693013916 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 545693013917 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 545693013918 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 545693013919 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 545693013920 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 545693013921 DHH family; Region: DHH; pfam01368 545693013922 DHHA1 domain; Region: DHHA1; pfam02272 545693013923 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 545693013924 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 545693013925 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 545693013926 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 545693013927 dimer interface [polypeptide binding]; other site 545693013928 ssDNA binding site [nucleotide binding]; other site 545693013929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 545693013930 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 545693013931 GTP-binding protein YchF; Reviewed; Region: PRK09601 545693013932 YchF GTPase; Region: YchF; cd01900 545693013933 G1 box; other site 545693013934 GTP/Mg2+ binding site [chemical binding]; other site 545693013935 Switch I region; other site 545693013936 G2 box; other site 545693013937 Switch II region; other site 545693013938 G3 box; other site 545693013939 G4 box; other site 545693013940 G5 box; other site 545693013941 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 545693013942 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 545693013943 Mechanosensitive ion channel; Region: MS_channel; pfam00924 545693013944 Uncharacterized membrane protein [Function unknown]; Region: COG3949 545693013945 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 545693013946 ParB-like partition proteins; Region: parB_part; TIGR00180 545693013947 ParB-like nuclease domain; Region: ParBc; cl02129 545693013948 KorB domain; Region: KorB; pfam08535 545693013949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013950 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 545693013951 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 545693013952 P-loop; other site 545693013953 Magnesium ion binding site [ion binding]; other site 545693013954 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 545693013955 Magnesium ion binding site [ion binding]; other site 545693013956 ParB-like partition proteins; Region: parB_part; TIGR00180 545693013957 ParB-like nuclease domain; Region: ParBc; cl02129 545693013958 Methyltransferase domain; Region: Methyltransf_31; pfam13847 545693013959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693013960 S-adenosylmethionine binding site [chemical binding]; other site 545693013961 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 545693013962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693013963 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 545693013964 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 545693013965 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 545693013966 trmE is a tRNA modification GTPase; Region: trmE; cd04164 545693013967 G1 box; other site 545693013968 GTP/Mg2+ binding site [chemical binding]; other site 545693013969 Switch I region; other site 545693013970 G2 box; other site 545693013971 Switch II region; other site 545693013972 G3 box; other site 545693013973 G4 box; other site 545693013974 G5 box; other site 545693013975 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 545693013976 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 545693013977 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 545693013978 G-X-X-G motif; other site 545693013979 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 545693013980 RxxxH motif; other site 545693013981 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 545693013982 Ribonuclease P; Region: Ribonuclease_P; cl00457 545693013983 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 545693013984 Beta-catenin-interacting protein ICAT; Region: ICAT; pfam06384 545693013985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693013986 putative DNA binding site [nucleotide binding]; other site 545693013987 putative Zn2+ binding site [ion binding]; other site 545693013988 dimerization interface [polypeptide binding]; other site 545693013989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693013990 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 545693013991 Replication-relaxation; Region: Replic_Relax; pfam13814 545693013992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693013993 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 545693013994 YolD-like protein; Region: YolD; pfam08863 545693013995 Helix-turn-helix domains; Region: HTH; cl00088 545693013996 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 545693013997 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 545693013998 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 545693013999 Walker A/P-loop; other site 545693014000 ATP binding site [chemical binding]; other site 545693014001 Q-loop/lid; other site 545693014002 ABC transporter signature motif; other site 545693014003 Walker B; other site 545693014004 D-loop; other site 545693014005 H-loop/switch region; other site 545693014006 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693014007 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 545693014008 active site 545693014009 8-oxo-dGMP binding site [chemical binding]; other site 545693014010 nudix motif; other site 545693014011 metal binding site [ion binding]; metal-binding site 545693014012 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 545693014013 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 545693014014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693014015 Helix-turn-helix domains; Region: HTH; cl00088 545693014016 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 545693014017 putative dimerization interface [polypeptide binding]; other site 545693014018 glutamate dehydrogenase; Provisional; Region: PRK09414 545693014019 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 545693014020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014021 NAD(P) binding pocket [chemical binding]; other site 545693014022 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 545693014023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014024 putative substrate translocation pore; other site 545693014025 FCD domain; Region: FCD; cl11656 545693014026 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693014027 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693014028 DNA-binding site [nucleotide binding]; DNA binding site 545693014029 RNA-binding motif; other site 545693014030 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 545693014031 DNA binding residues [nucleotide binding] 545693014032 dimer interface [polypeptide binding]; other site 545693014033 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 545693014034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 545693014035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 545693014036 YheO-like PAS domain; Region: PAS_6; pfam08348 545693014037 Helix-turn-helix domains; Region: HTH; cl00088 545693014038 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 545693014039 homotrimer interaction site [polypeptide binding]; other site 545693014040 putative active site [active] 545693014041 threonine synthase; Validated; Region: PRK08329 545693014042 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 545693014043 homodimer interface [polypeptide binding]; other site 545693014044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693014045 catalytic residue [active] 545693014046 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 545693014047 Helix-turn-helix domains; Region: HTH; cl00088 545693014048 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 545693014049 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693014050 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014052 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693014053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693014056 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 545693014057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014058 putative substrate translocation pore; other site 545693014059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014060 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693014061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014062 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693014063 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 545693014064 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 545693014065 Cupin domain; Region: Cupin_2; cl09118 545693014066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693014067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014068 O-Antigen ligase; Region: Wzy_C; cl04850 545693014069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693014070 DNA-binding site [nucleotide binding]; DNA binding site 545693014071 RNA-binding motif; other site 545693014072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014073 S-adenosylmethionine binding site [chemical binding]; other site 545693014074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014075 S-adenosylmethionine binding site [chemical binding]; other site 545693014076 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 545693014077 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 545693014078 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 545693014079 putative active site [active] 545693014080 putative NTP binding site [chemical binding]; other site 545693014081 putative nucleic acid binding site [nucleotide binding]; other site 545693014082 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 545693014083 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 545693014084 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 545693014085 putative active site [active] 545693014086 catalytic site [active] 545693014087 putative metal binding site [ion binding]; other site 545693014088 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 545693014089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014090 putative substrate translocation pore; other site 545693014091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014092 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 545693014093 putative substrate translocation pore; other site 545693014094 Helix-turn-helix domains; Region: HTH; cl00088 545693014095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693014096 Helix-turn-helix domains; Region: HTH; cl00088 545693014097 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 545693014098 putative active site [active] 545693014099 putative FMN binding site [chemical binding]; other site 545693014100 putative substrate binding site [chemical binding]; other site 545693014101 putative catalytic residue [active] 545693014102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 545693014103 Helix-turn-helix domains; Region: HTH; cl00088 545693014104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 545693014105 dimerization interface [polypeptide binding]; other site 545693014106 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 545693014107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014108 S-adenosylmethionine binding site [chemical binding]; other site 545693014109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014110 S-adenosylmethionine binding site [chemical binding]; other site 545693014111 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 545693014112 putative acyl-acceptor binding pocket; other site 545693014113 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 545693014114 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 545693014115 dimer interface [polypeptide binding]; other site 545693014116 active site 545693014117 CoA binding pocket [chemical binding]; other site 545693014118 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 545693014119 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 545693014120 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 545693014121 Spore germination protein; Region: Spore_permease; cl15802 545693014122 Spore germination protein; Region: Spore_permease; cl15802 545693014123 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 545693014124 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014125 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014126 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 545693014127 BCCT family transporter; Region: BCCT; cl00569 545693014128 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693014129 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693014130 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 545693014131 Ligand Binding Site [chemical binding]; other site 545693014132 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 545693014133 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693014134 Sulfate transporter family; Region: Sulfate_transp; cl15842 545693014135 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 545693014136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693014137 non-specific DNA binding site [nucleotide binding]; other site 545693014138 salt bridge; other site 545693014139 sequence-specific DNA binding site [nucleotide binding]; other site 545693014140 multiple promoter invertase; Provisional; Region: mpi; PRK13413 545693014141 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 545693014142 catalytic residues [active] 545693014143 catalytic nucleophile [active] 545693014144 Presynaptic Site I dimer interface [polypeptide binding]; other site 545693014145 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 545693014146 Synaptic Flat tetramer interface [polypeptide binding]; other site 545693014147 Synaptic Site I dimer interface [polypeptide binding]; other site 545693014148 DNA binding site [nucleotide binding] 545693014149 Helix-turn-helix domains; Region: HTH; cl00088 545693014150 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 545693014151 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 545693014152 CrcB-like protein; Region: CRCB; cl09114 545693014153 CrcB-like protein; Region: CRCB; cl09114 545693014154 Helix-turn-helix domains; Region: HTH; cl00088 545693014155 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 545693014156 nudix motif; other site 545693014157 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 545693014158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 545693014159 catalytic core [active] 545693014160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 545693014161 classical (c) SDRs; Region: SDR_c; cd05233 545693014162 NAD(P) binding site [chemical binding]; other site 545693014163 active site 545693014164 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 545693014165 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693014166 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693014167 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693014168 MatE; Region: MatE; cl10513 545693014169 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 545693014170 Coat F domain; Region: Coat_F; cl15836 545693014171 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 545693014172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693014173 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 545693014174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693014175 dimer interface [polypeptide binding]; other site 545693014176 active site 545693014177 DNA polymerase IV; Reviewed; Region: PRK03103 545693014178 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 545693014179 active site 545693014180 DNA binding site [nucleotide binding] 545693014181 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 545693014182 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 545693014183 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 545693014184 active site 545693014185 catalytic tetrad [active] 545693014186 4-carboxymuconolactone decarboxylase, frameshift 545693014187 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 545693014188 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 545693014189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014191 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 545693014192 DNA-binding site [nucleotide binding]; DNA binding site 545693014193 RNA-binding motif; other site 545693014194 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 545693014195 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 545693014196 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 545693014197 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 545693014198 Transposase; Region: DEDD_Tnp_IS110; pfam01548 545693014199 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 545693014200 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 545693014201 catalytic triad [active] 545693014202 conserved cis-peptide bond; other site 545693014203 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 545693014204 active site 545693014205 catalytic triad [active] 545693014206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 545693014207 dimerization interface [polypeptide binding]; other site 545693014208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 545693014209 dimer interface [polypeptide binding]; other site 545693014210 phosphorylation site [posttranslational modification] 545693014211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014212 ATP binding site [chemical binding]; other site 545693014213 Mg2+ binding site [ion binding]; other site 545693014214 G-X-G motif; other site 545693014215 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 545693014216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014217 active site 545693014218 phosphorylation site [posttranslational modification] 545693014219 intermolecular recognition site; other site 545693014220 dimerization interface [polypeptide binding]; other site 545693014221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 545693014222 DNA binding site [nucleotide binding] 545693014223 FtsX-like permease family; Region: FtsX; cl15850 545693014224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 545693014225 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 545693014226 Walker A/P-loop; other site 545693014227 ATP binding site [chemical binding]; other site 545693014228 Q-loop/lid; other site 545693014229 ABC transporter signature motif; other site 545693014230 Walker B; other site 545693014231 D-loop; other site 545693014232 H-loop/switch region; other site 545693014233 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693014234 ABC-2 type transporter; Region: ABC2_membrane; cl11417 545693014235 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 545693014236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693014237 Walker A/P-loop; other site 545693014238 ATP binding site [chemical binding]; other site 545693014239 Q-loop/lid; other site 545693014240 ABC transporter signature motif; other site 545693014241 Walker B; other site 545693014242 D-loop; other site 545693014243 H-loop/switch region; other site 545693014244 Flavoprotein; Region: Flavoprotein; cl08021 545693014245 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 545693014246 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 545693014247 active site 545693014248 zinc binding site [ion binding]; other site 545693014249 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 545693014250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693014251 Walker A/P-loop; other site 545693014252 ATP binding site [chemical binding]; other site 545693014253 Q-loop/lid; other site 545693014254 ABC transporter signature motif; other site 545693014255 Walker B; other site 545693014256 D-loop; other site 545693014257 H-loop/switch region; other site 545693014258 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 545693014259 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 545693014260 SpaB C-terminal domain; Region: SpaB_C; cl14828 545693014261 Gallidermin; Region: Gallidermin; cl03420 545693014262 Gallidermin; Region: Gallidermin; cl03420 545693014263 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 545693014264 substrate-Mg2+ binding site; other site 545693014265 substrate binding pocket [chemical binding]; other site 545693014266 aspartate-rich region 2; other site 545693014267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 545693014268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 545693014269 ATP binding site [chemical binding]; other site 545693014270 Mg2+ binding site [ion binding]; other site 545693014271 G-X-G motif; other site 545693014272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 545693014273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 545693014274 active site 545693014275 phosphorylation site [posttranslational modification] 545693014276 intermolecular recognition site; other site 545693014277 dimerization interface [polypeptide binding]; other site 545693014278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 545693014279 DNA binding residues [nucleotide binding] 545693014280 dimerization interface [polypeptide binding]; other site 545693014281 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 545693014282 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 545693014283 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 545693014284 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 545693014285 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 545693014286 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 545693014287 active site 545693014288 metal-binding site 545693014289 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 545693014290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 545693014291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 545693014292 homodimer interface [polypeptide binding]; other site 545693014293 catalytic residue [active] 545693014294 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 545693014295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 545693014296 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693014297 argininosuccinate lyase; Provisional; Region: PRK02186 545693014298 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693014299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014300 putative substrate translocation pore; other site 545693014301 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 545693014302 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693014303 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 545693014304 FixH; Region: FixH; cl01254 545693014305 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 545693014306 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 545693014307 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 545693014308 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 545693014309 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693014310 active site 545693014311 catalytic residues [active] 545693014312 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206 545693014313 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 545693014314 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693014315 DNA binding residues [nucleotide binding] 545693014316 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 545693014317 Replication-relaxation; Region: Replic_Relax; pfam13814 545693014318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693014319 hypothetical protein; Provisional; Region: PRK14082 545693014320 YvrJ protein family; Region: YvrJ; pfam12841 545693014321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 545693014322 Helix-turn-helix domains; Region: HTH; cl00088 545693014323 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 545693014324 NADH(P)-binding; Region: NAD_binding_10; pfam13460 545693014325 NAD binding site [chemical binding]; other site 545693014326 substrate binding site [chemical binding]; other site 545693014327 putative active site [active] 545693014328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 545693014329 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 545693014330 active site 545693014331 metal binding site [ion binding]; metal-binding site 545693014332 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 545693014333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014334 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 545693014335 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 545693014336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693014337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 545693014338 DNA binding residues [nucleotide binding] 545693014339 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 545693014340 Putative zinc-finger; Region: zf-HC2; cl15806 545693014341 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 545693014342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014343 non-specific DNA binding site [nucleotide binding]; other site 545693014344 salt bridge; other site 545693014345 sequence-specific DNA binding site [nucleotide binding]; other site 545693014346 YolD-like protein; Region: YolD; pfam08863 545693014347 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 545693014348 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 545693014349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014350 putative substrate translocation pore; other site 545693014351 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 545693014352 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693014353 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 545693014354 dimer interface [polypeptide binding]; other site 545693014355 active site 545693014356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 545693014357 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 545693014358 dimer interface [polypeptide binding]; other site 545693014359 active site 545693014360 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 545693014361 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 545693014362 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 545693014363 Phosphopantetheine attachment site; Region: PP-binding; cl09936 545693014364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 545693014365 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 545693014366 NAD(P) binding site [chemical binding]; other site 545693014367 homotetramer interface [polypeptide binding]; other site 545693014368 homodimer interface [polypeptide binding]; other site 545693014369 active site 545693014370 Acyl transferase domain; Region: Acyl_transf_1; cl08282 545693014371 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 545693014372 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 545693014373 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 545693014374 active site 545693014375 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 545693014376 classical (c) SDRs; Region: SDR_c; cd05233 545693014377 NAD(P) binding site [chemical binding]; other site 545693014378 active site 545693014379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 545693014380 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 545693014381 Coenzyme A binding pocket [chemical binding]; other site 545693014382 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693014383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014384 putative substrate translocation pore; other site 545693014385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 545693014386 putative DNA binding site [nucleotide binding]; other site 545693014387 dimerization interface [polypeptide binding]; other site 545693014388 putative Zn2+ binding site [ion binding]; other site 545693014389 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 545693014390 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 545693014391 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 545693014392 dimer interface [polypeptide binding]; other site 545693014393 putative tRNA-binding site [nucleotide binding]; other site 545693014394 EamA-like transporter family; Region: EamA; cl01037 545693014395 EamA-like transporter family; Region: EamA; cl01037 545693014396 Heat induced stress protein YflT; Region: YflT; pfam11181 545693014397 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 545693014398 active site 545693014399 catalytic triad [active] 545693014400 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693014401 catalytic residues [active] 545693014402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 545693014403 non-specific DNA binding site [nucleotide binding]; other site 545693014404 salt bridge; other site 545693014405 sequence-specific DNA binding site [nucleotide binding]; other site 545693014406 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 545693014407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693014408 active site 545693014409 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 545693014410 putative metal binding site; other site 545693014411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 545693014412 binding surface 545693014413 TPR motif; other site 545693014414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 545693014416 S-adenosylmethionine binding site [chemical binding]; other site 545693014417 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 545693014418 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 545693014419 DNA binding residues [nucleotide binding] 545693014420 H+ Antiporter protein; Region: 2A0121; TIGR00900 545693014421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 545693014423 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 545693014424 RNA polymerase factor sigma-70; Validated; Region: PRK08295 545693014425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 545693014426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 545693014427 Initiator Replication protein; Region: Rep_3; cl03080 545693014428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 545693014429 active site 545693014430 Int/Topo IB signature motif; other site 545693014431 DNA binding site [nucleotide binding] 545693014432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 545693014433 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 545693014434 DNA binding residues [nucleotide binding] 545693014435 Probable phenylalanyl-tRNA synthetase alpha chain; Region: PLN02853 545693014436 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 545693014437 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693014438 catalytic residues [active] 545693014439 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 545693014440 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693014441 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 545693014442 active site 545693014443 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 545693014444 homodimer interface [polypeptide binding]; other site 545693014445 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 545693014446 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 545693014447 NAD(P) binding site [chemical binding]; other site 545693014448 homodimer interface [polypeptide binding]; other site 545693014449 substrate binding site [chemical binding]; other site 545693014450 active site 545693014451 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 545693014452 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 545693014453 NADP binding site [chemical binding]; other site 545693014454 active site 545693014455 putative substrate binding site [chemical binding]; other site 545693014456 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693014457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 545693014458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014459 NAD(P) binding site [chemical binding]; other site 545693014460 active site 545693014461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693014462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693014463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014464 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 545693014465 NAD(P) binding site [chemical binding]; other site 545693014466 active site 545693014467 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 545693014468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693014469 active site 545693014470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693014471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693014472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 545693014473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693014474 active site 545693014475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693014476 active site 545693014477 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693014478 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693014479 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693014480 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 545693014481 putative transposase, point mutation 545693014482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014484 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014485 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014486 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 545693014487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 545693014488 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 545693014489 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 545693014490 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693014491 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693014492 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 545693014493 active site 545693014494 ATP binding site [chemical binding]; other site 545693014495 putative transposase OrfB; Reviewed; Region: PHA02517 545693014496 HTH-like domain; Region: HTH_21; pfam13276 545693014497 Integrase core domain; Region: rve; cl01316 545693014498 Integrase core domain; Region: rve_3; cl15866 545693014499 Helix-turn-helix domains; Region: HTH; cl00088 545693014500 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 545693014501 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014502 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014503 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014504 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014505 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014506 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 545693014507 Transposase, Mutator family; Region: Transposase_mut; pfam00872 545693014508 MULE transposase domain; Region: MULE; pfam10551 545693014509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 545693014510 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 545693014511 FAD binding domain; Region: FAD_binding_4; pfam01565 545693014512 Berberine and berberine like; Region: BBE; pfam08031 545693014513 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 545693014514 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 545693014515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 545693014516 Homeobox prospero-like protein (PROX1); Region: Prox1; pfam05044 545693014517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 545693014518 active site 545693014519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 545693014520 SPW repeat; Region: SPW; pfam03779 545693014521 Transposase, Mutator family; Region: Transposase_mut; pfam00872 545693014522 MULE transposase domain; Region: MULE; pfam10551 545693014523 Helix-turn-helix domains; Region: HTH; cl00088 545693014524 putative transposase OrfB; Reviewed; Region: PHA02517 545693014525 HTH-like domain; Region: HTH_21; pfam13276 545693014526 Integrase core domain; Region: rve; cl01316 545693014527 Integrase core domain; Region: rve_3; cl15866 545693014528 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 545693014529 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693014530 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 545693014531 Protein of unknown function (DUF421); Region: DUF421; cl00990 545693014532 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693014533 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 545693014534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 545693014535 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 545693014536 Helix-turn-helix domains; Region: HTH; cl00088 545693014537 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 545693014538 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 545693014539 putative transposase, frameshift 545693014540 Helix-turn-helix domains; Region: HTH; cl00088 545693014541 putative transposase OrfB; Reviewed; Region: PHA02517 545693014542 HTH-like domain; Region: HTH_21; pfam13276 545693014543 Integrase core domain; Region: rve; cl01316 545693014544 Integrase core domain; Region: rve_3; cl15866 545693014545 argininosuccinate lyase; Provisional; Region: PRK02186 545693014546 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693014547 ATP-grasp domain; Region: ATP-grasp_4; cl03087 545693014548 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 545693014549 Helix-turn-helix domains; Region: HTH; cl00088